DK275489A - Makrolid-biosyntesegener til anvendelse i streptomyces og andre organismer - Google Patents

Makrolid-biosyntesegener til anvendelse i streptomyces og andre organismer Download PDF

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Publication number
DK275489A
DK275489A DK275489A DK275489A DK275489A DK 275489 A DK275489 A DK 275489A DK 275489 A DK275489 A DK 275489A DK 275489 A DK275489 A DK 275489A DK 275489 A DK275489 A DK 275489A
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DK
Denmark
Prior art keywords
macrolid
biosynth
streptomyces
organisms
synthesis
Prior art date
Application number
DK275489A
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English (en)
Other versions
DK275489D0 (da
Inventor
Robert John Beckmann
Karen Leigh Cox
Ramachandra Nagaraja Rao
Mark Alan Richardson
Eugene Thomas Seno
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK275489D0 publication Critical patent/DK275489D0/da
Publication of DK275489A publication Critical patent/DK275489A/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK275489A 1988-06-07 1989-06-06 Makrolid-biosyntesegener til anvendelse i streptomyces og andre organismer DK275489A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/203,387 US5098837A (en) 1988-06-07 1988-06-07 Macrolide biosynthetic genes for use in streptomyces and other organisms

Publications (2)

Publication Number Publication Date
DK275489D0 DK275489D0 (da) 1989-06-06
DK275489A true DK275489A (da) 1989-12-08

Family

ID=22753777

Family Applications (1)

Application Number Title Priority Date Filing Date
DK275489A DK275489A (da) 1988-06-07 1989-06-06 Makrolid-biosyntesegener til anvendelse i streptomyces og andre organismer

Country Status (5)

Country Link
US (1) US5098837A (da)
EP (1) EP0346000A3 (da)
JP (1) JPH0239889A (da)
DK (1) DK275489A (da)
IL (1) IL90496A0 (da)

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JP2749616B2 (ja) * 1988-05-24 1998-05-13 メルシャン株式会社 マクロライド抗生物質の４”位アシル化酵素をコードする遺伝子
EP0468220A3 (en) * 1990-07-26 1992-09-23 American Cyanamid Company Cloning of the biosynthetic pathway genes for chlortetracycline production from streptomyces aureofaciens & their expression in steptomyces lividans
US5589385A (en) * 1990-07-26 1996-12-31 American Cyanamid Company Cloning of the biosynthetic pathway for chlortetracycline and tetracycline formation and cosmids useful therein
ATE166391T1 (de) * 1990-07-26 1998-06-15 American Cyanamid Co Zur actinomyceten-dns-klonierung nützliches bifunktionelles cosmid
US5514544A (en) * 1991-07-26 1996-05-07 Eli Lilly And Company Activator gene for macrolide biosynthesis
US6066721A (en) * 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
US6500960B1 (en) 1995-07-06 2002-12-31 Stanford University (Board Of Trustees Of The Leland Stanford Junior University) Method to produce novel polyketides
US6558942B1 (en) 1994-05-06 2003-05-06 The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US20030170725A1 (en) * 1993-09-20 2003-09-11 Chaitan Khosla Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
FR2713658B1 (fr) * 1993-12-08 1996-04-12 Rhone Poulenc Rorer Sa Séquences d'acides nucléiques régulatrices et utilisations.
WO1997002358A1 (en) * 1995-07-06 1997-01-23 The Leland Stanford Junior University Cell-free synthesis of polyketides
EP0870053A4 (en) 1995-12-19 2002-09-11 Univ Minnesota METABOLIC PROCESS FOR THE MANUFACTURE OF POLYHYDROXYALCANOATE MONOMER SYNTHASES
CA2197524A1 (en) * 1996-02-22 1997-08-22 Bradley Stuart Dehoff Polyketide synthase genes
CA2197160C (en) * 1996-02-22 2007-05-01 Stanley Gene Burgett Platenolide synthase gene
US6117659A (en) 1997-04-30 2000-09-12 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
US20040209322A1 (en) * 1997-04-30 2004-10-21 Chaitan Khosla Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6503741B1 (en) 1998-05-28 2003-01-07 Kosan Biosciences, Inc. Polyketide synthase genes from Streptomyces venezuelae
US20080003648A1 (en) * 1997-04-30 2008-01-03 Chaitan Khosla Method to prepare macrolide analogs
US6902913B2 (en) * 1997-04-30 2005-06-07 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
US6262340B1 (en) 1997-07-10 2001-07-17 Kosan Biosciences, Inc. Production of polyketides in plants
US7713703B1 (en) 2000-11-13 2010-05-11 Biosite, Inc. Methods for monitoring the status of assays and immunoassays
US6090601A (en) * 1998-01-23 2000-07-18 Kosan Bioscience Sorangium polyketide synthase
US6280999B1 (en) 1998-01-23 2001-08-28 Kosan Bioscience Sorangium polyketide synthases and encoding DNA therefor
US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
US6150513A (en) * 1998-09-16 2000-11-21 Kosan Biosciences, Inc. Polyketide synthase enzymes and recombinant DNA constructs therefor
US6177262B1 (en) 1998-09-22 2001-01-23 Kosan Biosciences, Inc. Recombinant host cells for the production of polyketides
CN1329668A (zh) * 1998-10-02 2002-01-02 高山生物科学股份有限公司 多聚乙酰合成酶及其重组dna构建物
AU1447700A (en) 1998-10-28 2000-05-15 Kosan Biosciences, Inc. Library of novel "unnatural" natural products
US20040005673A1 (en) * 2001-06-29 2004-01-08 Kevin Jarrell System for manipulating nucleic acids
WO2000040715A2 (en) 1999-01-05 2000-07-13 Trustees Of Boston University Improved nucleic acid cloning
US20040235107A1 (en) * 1999-01-29 2004-11-25 Ramot At Tel Aviv University Ltd. Biosynthesis of TA antibiotic
US6596875B2 (en) 2000-02-07 2003-07-22 James David White Method for synthesizing epothilones and epothilone analogs
US7001748B2 (en) * 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
US6753173B1 (en) 1999-02-09 2004-06-22 Board Of Trustees Of The Leland Stanford Junior University Methods to mediate polyketide synthase module effectiveness
US6569867B2 (en) 1999-10-01 2003-05-27 Kosan Biosciences, Inc. Polyketide derivatives
DE60043509D1 (de) 1999-10-13 2010-01-21 Nior University Biosynthese von Polyketidsynthase-Substrate
CA2392753A1 (en) 1999-12-10 2001-06-14 Invitrogen Corporation Use of multiple recombination sites with unique specificity in recombinational cloning
US20030077759A1 (en) * 2000-12-28 2003-04-24 Zhihao Hu Plasmids for polyketide production
US20030194784A1 (en) * 2001-04-17 2003-10-16 Sherman David H. DNA encoding methymycin and pikromycin
JP2004535175A (ja) * 2001-04-26 2004-11-25 エコピア バイオサイエンシーズ インク ポリケチド生合成用遺伝子及びタンパク質
US20070203346A1 (en) * 2001-04-30 2007-08-30 Oregon State University Method for synthesizing epothilones and epothilone analogs
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ATE321139T1 (de) * 2001-07-26 2006-04-15 Ecopia Biosciences Inc Gene und proteine zur rosaramicin biosynthese
AU2003213757A1 (en) * 2002-03-04 2003-09-22 Brown University Research Foundation Methods to mediate polyketide synthase module effectiveness
US7427493B2 (en) 2002-06-28 2008-09-23 Kosan Biosciences Incorporated Recombinant genes for polyketide modifying enzymes
EP1905833B1 (fr) 2002-10-08 2015-08-12 Aventis Pharma S.A. Polypeptides impliqués dans la biosynthèse des spiramycines, séquences nucléotidiques codant ces polypeptides et leurs applications
US7579167B2 (en) * 2002-10-08 2009-08-25 Aventis Pharma S. Polypeptides involved in the biosynthesis of spiramycins, nucleotide sequences encoding these polypeptides and applications thereof
EP1551975A2 (fr) * 2002-10-08 2005-07-13 Aventis Pharma S.A. Polypeptides impliques dans la biosynthese des spiramycines, sequences nucleotidiques codant ces polypeptides et leur utilisation
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AU2003298864A1 (en) * 2002-12-06 2004-06-30 Kosan Biosciences, Inc. Disorazole polyketide synthase encoding polynucleotides
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US7229814B2 (en) * 2004-05-05 2007-06-12 Regents Of The University Of Minnesota Nucleic acids and polypeptides involved in the production of cryptophycin
US7566558B2 (en) 2006-07-28 2009-07-28 Regents Of The University Of Michigan Nucleic acids and polypeptides involved in the production of cryptophycin
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US9115359B2 (en) * 2007-04-02 2015-08-25 Newsouth Innovations Pty Limited Methods for producing secondary metabolites
US8759031B2 (en) * 2007-04-12 2014-06-24 Wisconsin Alumni Research Foundation Type I polyketide synthase extender units
JP2014508516A (ja) 2011-01-28 2014-04-10 アミリス， インコーポレイテッド ゲルに封入されたマイクロコロニーのスクリーニング
CA2834783A1 (en) 2011-05-13 2012-11-22 Amyris, Inc. Methods and compositions for detecting microbial production of water-immiscible compounds
CN102373171B (zh) * 2011-11-01 2013-08-14 中国科学院南海海洋研究所 一种核苷类抗生素a201a高产菌株及其构建方法
BR112015002724B1 (pt) 2012-08-07 2022-02-01 Total Marketing Services Método para produzir um composto não catabólico heterólogo, e, composição de fermentação
MX364748B (es) 2013-03-15 2019-05-06 Amyris Inc Uso de fosfoquetolasa y fosfotransacetilasa para la produccion de compuestos derivados de acetil-coenzima a.
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Family Cites Families (4)

* Cited by examiner, † Cited by third party
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US4753880A (en) * 1984-12-24 1988-06-28 Eli Lilly And Company Method of selection for spiramycin resistance in streptomyces
US4713337A (en) * 1985-01-03 1987-12-15 Massachusetts Institute Of Technology Method for deletion of a gene from a bacteria
US4935340A (en) * 1985-06-07 1990-06-19 Eli Lilly And Company Method of isolating antibiotic biosynthetic genes
US4904598A (en) * 1986-03-20 1990-02-27 Eli Lilly And Company Novel plasmid shuttle vectors conferring spiramycin resistance in streptomyces

Also Published As

Publication number Publication date
DK275489D0 (da) 1989-06-06
JPH0239889A (ja) 1990-02-08
EP0346000A3 (en) 1991-07-03
US5098837A (en) 1992-03-24
EP0346000A2 (en) 1989-12-13
IL90496A0 (en) 1990-01-18

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