DK275489A - Makrolid-biosyntesegener til anvendelse i streptomyces og andre organismer - Google Patents
Makrolid-biosyntesegener til anvendelse i streptomyces og andre organismer Download PDFInfo
- Publication number
- DK275489A DK275489A DK275489A DK275489A DK275489A DK 275489 A DK275489 A DK 275489A DK 275489 A DK275489 A DK 275489A DK 275489 A DK275489 A DK 275489A DK 275489 A DK275489 A DK 275489A
- Authority
- DK
- Denmark
- Prior art keywords
- macrolid
- biosynth
- streptomyces
- organisms
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/203,387 US5098837A (en) | 1988-06-07 | 1988-06-07 | Macrolide biosynthetic genes for use in streptomyces and other organisms |
Publications (2)
Publication Number | Publication Date |
---|---|
DK275489D0 DK275489D0 (da) | 1989-06-06 |
DK275489A true DK275489A (da) | 1989-12-08 |
Family
ID=22753777
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK275489A DK275489A (da) | 1988-06-07 | 1989-06-06 | Makrolid-biosyntesegener til anvendelse i streptomyces og andre organismer |
Country Status (5)
Country | Link |
---|---|
US (1) | US5098837A (da) |
EP (1) | EP0346000A3 (da) |
JP (1) | JPH0239889A (da) |
DK (1) | DK275489A (da) |
IL (1) | IL90496A0 (da) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2749616B2 (ja) * | 1988-05-24 | 1998-05-13 | メルシャン株式会社 | マクロライド抗生物質の4”位アシル化酵素をコードする遺伝子 |
EP0468220A3 (en) * | 1990-07-26 | 1992-09-23 | American Cyanamid Company | Cloning of the biosynthetic pathway genes for chlortetracycline production from streptomyces aureofaciens & their expression in steptomyces lividans |
US5589385A (en) * | 1990-07-26 | 1996-12-31 | American Cyanamid Company | Cloning of the biosynthetic pathway for chlortetracycline and tetracycline formation and cosmids useful therein |
ES2117630T3 (es) * | 1990-07-26 | 1998-08-16 | American Cyanamid Co | Cosmido bifuncional util para clonar adn actinomicetico. |
US5514544A (en) * | 1991-07-26 | 1996-05-07 | Eli Lilly And Company | Activator gene for macrolide biosynthesis |
US6066721A (en) * | 1995-07-06 | 2000-05-23 | Stanford University | Method to produce novel polyketides |
US6500960B1 (en) | 1995-07-06 | 2002-12-31 | Stanford University (Board Of Trustees Of The Leland Stanford Junior University) | Method to produce novel polyketides |
US20030170725A1 (en) * | 1993-09-20 | 2003-09-11 | Chaitan Khosla | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
US6558942B1 (en) | 1994-05-06 | 2003-05-06 | The Leland Stanford Junior University | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
FR2713658B1 (fr) * | 1993-12-08 | 1996-04-12 | Rhone Poulenc Rorer Sa | Séquences d'acides nucléiques régulatrices et utilisations. |
JP3633629B2 (ja) * | 1995-07-06 | 2005-03-30 | ザ レランド スタンフォード ジュニア ユニバーシティ | ポリケチドの無細胞合成 |
EP0870053A4 (en) | 1995-12-19 | 2002-09-11 | Univ Minnesota | METABOLIC PROCESS FOR THE MANUFACTURE OF POLYHYDROXYALCANOATE MONOMER SYNTHASES |
CA2197524A1 (en) * | 1996-02-22 | 1997-08-22 | Bradley Stuart Dehoff | Polyketide synthase genes |
CA2197160C (en) * | 1996-02-22 | 2007-05-01 | Stanley Gene Burgett | Platenolide synthase gene |
US6503741B1 (en) | 1998-05-28 | 2003-01-07 | Kosan Biosciences, Inc. | Polyketide synthase genes from Streptomyces venezuelae |
US20040209322A1 (en) * | 1997-04-30 | 2004-10-21 | Chaitan Khosla | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
US6117659A (en) | 1997-04-30 | 2000-09-12 | Kosan Biosciences, Inc. | Recombinant narbonolide polyketide synthase |
US6902913B2 (en) * | 1997-04-30 | 2005-06-07 | Kosan Biosciences, Inc. | Recombinant narbonolide polyketide synthase |
US20080003648A1 (en) * | 1997-04-30 | 2008-01-03 | Chaitan Khosla | Method to prepare macrolide analogs |
AU744751C (en) | 1997-07-10 | 2005-11-24 | Kosan Biosciences, Inc. | Production of polyketides in plants |
US7713703B1 (en) | 2000-11-13 | 2010-05-11 | Biosite, Inc. | Methods for monitoring the status of assays and immunoassays |
US6280999B1 (en) | 1998-01-23 | 2001-08-28 | Kosan Bioscience | Sorangium polyketide synthases and encoding DNA therefor |
US6090601A (en) * | 1998-01-23 | 2000-07-18 | Kosan Bioscience | Sorangium polyketide synthase |
US6265202B1 (en) | 1998-06-26 | 2001-07-24 | Regents Of The University Of Minnesota | DNA encoding methymycin and pikromycin |
US6150513A (en) * | 1998-09-16 | 2000-11-21 | Kosan Biosciences, Inc. | Polyketide synthase enzymes and recombinant DNA constructs therefor |
US6177262B1 (en) | 1998-09-22 | 2001-01-23 | Kosan Biosciences, Inc. | Recombinant host cells for the production of polyketides |
CA2343880C (en) | 1998-10-02 | 2008-08-26 | Kosan Biosciences, Inc. | Polyketide synthase enzymes and recombinant dna constructs therefor |
JP2002528467A (ja) * | 1998-10-28 | 2002-09-03 | コーサン バイオサイエンシーズ, インコーポレイテッド | 新規な「不自然な(unnatural)」天然生成物のライブラリ |
US20040005673A1 (en) * | 2001-06-29 | 2004-01-08 | Kevin Jarrell | System for manipulating nucleic acids |
JP2002537762A (ja) | 1999-01-05 | 2002-11-12 | トラスティーズ オブ ボストン ユニバーシティ | 改良型核酸クローニング |
US20040235107A1 (en) * | 1999-01-29 | 2004-11-25 | Ramot At Tel Aviv University Ltd. | Biosynthesis of TA antibiotic |
US6596875B2 (en) * | 2000-02-07 | 2003-07-22 | James David White | Method for synthesizing epothilones and epothilone analogs |
JP2002536014A (ja) | 1999-02-09 | 2002-10-29 | ザ、ボード、オブ、トラスティーズ、オブ、ザ、リーランド、スタンフォード、ジュニア、ユニバーシティ | ポリケチドシンターゼモジュールの有効性を媒介する方法 |
US7001748B2 (en) * | 1999-02-09 | 2006-02-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of making polyketides using hybrid polyketide synthases |
US6569867B2 (en) | 1999-10-01 | 2003-05-27 | Kosan Biosciences, Inc. | Polyketide derivatives |
IL148439A0 (en) | 1999-10-13 | 2002-09-12 | Univ Leland Stanford Junior | Biosynthesis of polyketide synthase substrates |
EP1978098A3 (en) | 1999-12-10 | 2009-02-18 | Invitrogen Corporation | Use of multiple recombination sites with unique specificity in recombinational cloning |
US20030077759A1 (en) * | 2000-12-28 | 2003-04-24 | Zhihao Hu | Plasmids for polyketide production |
US20030194784A1 (en) * | 2001-04-17 | 2003-10-16 | Sherman David H. | DNA encoding methymycin and pikromycin |
CA2415339A1 (en) * | 2001-04-26 | 2002-11-07 | Ecopia Biosciences Inc. | Genes and proteins for the biosynthesis of polyketides |
US20070203346A1 (en) * | 2001-04-30 | 2007-08-30 | Oregon State University | Method for synthesizing epothilones and epothilone analogs |
US7300633B2 (en) * | 2001-07-25 | 2007-11-27 | Oakville Hong Kong Company Limited | Specimen collection container |
WO2003010193A2 (en) * | 2001-07-26 | 2003-02-06 | Ecopia Biosciences Inc. | Genes and proteins for the biosynthesis of rosaramicin |
WO2003076581A2 (en) * | 2002-03-04 | 2003-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Methods to mediate polyketide synthase module effectiveness |
US7427493B2 (en) | 2002-06-28 | 2008-09-23 | Kosan Biosciences Incorporated | Recombinant genes for polyketide modifying enzymes |
EP1905833B1 (fr) | 2002-10-08 | 2015-08-12 | Aventis Pharma S.A. | Polypeptides impliqués dans la biosynthèse des spiramycines, séquences nucléotidiques codant ces polypeptides et leurs applications |
US7579167B2 (en) * | 2002-10-08 | 2009-08-25 | Aventis Pharma S. | Polypeptides involved in the biosynthesis of spiramycins, nucleotide sequences encoding these polypeptides and applications thereof |
BRPI0314543B8 (pt) * | 2002-10-08 | 2021-05-25 | Aventis Pharma Sa | células hospedeiras, dna recombinante, utilização dos mesmos, processos de produção de um polipeptídeo implicado na biossíntese das espiramicinas, de produção de macrolídeos e de produção de espiramicina(s), e micro-organismo transgênico mutante produtor de macrolídeo |
DE10248453A1 (de) * | 2002-10-17 | 2004-05-13 | Biofrontera Discovery Gmbh | Chalcomycin-Derivate |
US7364877B2 (en) * | 2002-12-06 | 2008-04-29 | Kosan Biosciences, Inc. | Polynucleotides encoding disorazole polyketide synthase polypeptides |
KR100549690B1 (ko) | 2003-10-23 | 2006-02-07 | 상하이 지아오통 대학 | 에프알-008 폴리케타이드 합성에 관여하는 유전자 |
US7229814B2 (en) * | 2004-05-05 | 2007-06-12 | Regents Of The University Of Minnesota | Nucleic acids and polypeptides involved in the production of cryptophycin |
US7566558B2 (en) * | 2006-07-28 | 2009-07-28 | Regents Of The University Of Michigan | Nucleic acids and polypeptides involved in the production of cryptophycin |
FI119228B (fi) | 2006-12-05 | 2008-09-15 | Sandvik Mining & Constr Oy | Rikotuslaitteen työkalun laakerointi |
ES2615629T3 (es) * | 2007-04-02 | 2017-06-07 | Newsouth Innovations Pty Limited | Métodos para producir metabolitos secundarios |
US8759031B2 (en) * | 2007-04-12 | 2014-06-24 | Wisconsin Alumni Research Foundation | Type I polyketide synthase extender units |
MX2013008062A (es) | 2011-01-28 | 2013-08-09 | Amyris Inc | Seleccion de microcolonias encapsuladas en gel. |
KR20140032438A (ko) | 2011-05-13 | 2014-03-14 | 아미리스 인코퍼레이티드 | 수혼화성 화합물의 미생물 생산의 검출 방법 및 조성물 |
CN102373171B (zh) * | 2011-11-01 | 2013-08-14 | 中国科学院南海海洋研究所 | 一种核苷类抗生素a201a高产菌株及其构建方法 |
CA2879178C (en) | 2012-08-07 | 2020-11-24 | Amyris, Inc. | Methods for stabilizing production of acetyl-coenzyme a derived compounds |
AU2014227811C1 (en) | 2013-03-15 | 2018-09-27 | Amyris, Inc. | Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds |
EP3030662B1 (en) | 2013-08-07 | 2020-01-15 | Amyris, Inc. | Methods for stabilizing production of acetyl-coenzyme a derived compounds |
US10808015B2 (en) | 2015-06-25 | 2020-10-20 | Amyris, Inc. | Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4753880A (en) * | 1984-12-24 | 1988-06-28 | Eli Lilly And Company | Method of selection for spiramycin resistance in streptomyces |
US4713337A (en) * | 1985-01-03 | 1987-12-15 | Massachusetts Institute Of Technology | Method for deletion of a gene from a bacteria |
US4935340A (en) * | 1985-06-07 | 1990-06-19 | Eli Lilly And Company | Method of isolating antibiotic biosynthetic genes |
US4904598A (en) * | 1986-03-20 | 1990-02-27 | Eli Lilly And Company | Novel plasmid shuttle vectors conferring spiramycin resistance in streptomyces |
-
1988
- 1988-06-07 US US07/203,387 patent/US5098837A/en not_active Expired - Fee Related
-
1989
- 1989-06-01 IL IL90496A patent/IL90496A0/xx unknown
- 1989-06-01 EP EP19890305515 patent/EP0346000A3/en not_active Withdrawn
- 1989-06-06 JP JP1146555A patent/JPH0239889A/ja active Pending
- 1989-06-06 DK DK275489A patent/DK275489A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL90496A0 (en) | 1990-01-18 |
DK275489D0 (da) | 1989-06-06 |
EP0346000A3 (en) | 1991-07-03 |
US5098837A (en) | 1992-03-24 |
EP0346000A2 (en) | 1989-12-13 |
JPH0239889A (ja) | 1990-02-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ATS | Application withdrawn |