DK27383A - Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner - Google Patents
Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner Download PDFInfo
- Publication number
- DK27383A DK27383A DK27383A DK27383A DK27383A DK 27383 A DK27383 A DK 27383A DK 27383 A DK27383 A DK 27383A DK 27383 A DK27383 A DK 27383A DK 27383 A DK27383 A DK 27383A
- Authority
- DK
- Denmark
- Prior art keywords
- pyridines
- procedure
- preparing pyrazole
- pyrazole
- preparing
- Prior art date
Links
- RQMWVVBHJMUJNZ-UHFFFAOYSA-N 4-chloropyridin-2-amine Chemical compound NC1=CC(Cl)=CC=N1 RQMWVVBHJMUJNZ-UHFFFAOYSA-N 0.000 title 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- 239000003874 central nervous system depressant Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8204722 | 1982-02-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK27383D0 DK27383D0 (da) | 1983-01-25 |
| DK27383A true DK27383A (da) | 1983-08-18 |
Family
ID=10528419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK27383A DK27383A (da) | 1982-02-17 | 1983-01-25 | Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4500525A (https=) |
| EP (1) | EP0086422B1 (https=) |
| JP (1) | JPS58152885A (https=) |
| KR (1) | KR900006853B1 (https=) |
| AT (1) | ATE30027T1 (https=) |
| AU (1) | AU563591B2 (https=) |
| CA (1) | CA1225646A (https=) |
| DE (1) | DE3373904D1 (https=) |
| DK (1) | DK27383A (https=) |
| ES (3) | ES8500273A1 (https=) |
| GR (1) | GR78080B (https=) |
| IE (1) | IE55156B1 (https=) |
| IL (1) | IL67785A0 (https=) |
| NZ (1) | NZ203302A (https=) |
| PH (1) | PH23645A (https=) |
| ZA (1) | ZA83628B (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5137890A (en) * | 1990-02-14 | 1992-08-11 | Ortho Pharmaceutical Corporation | 4-phenyl tetrahydropyrido(4,3-d)pyrimidines |
| US5264576A (en) * | 1992-10-22 | 1993-11-23 | Hoechst-Roussel Pharmaceuticals Incorporated | Pyrazolo[4,3-c]pyridines which are intermediates |
| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| EP1309591B1 (en) * | 2000-08-14 | 2007-01-24 | Ortho-McNeil Pharmaceutical, Inc. | Substituted pyrazoles |
| US20050101587A9 (en) * | 2000-08-14 | 2005-05-12 | Butler Christopher R. | Method for treating allergies using substituted pyrazoles |
| EP1309593B1 (en) | 2000-08-14 | 2006-03-15 | Ortho-McNeil Pharmaceutical, Inc. | Substituted pyrazoles |
| US20070105841A1 (en) * | 2000-08-14 | 2007-05-10 | Breitenbucher J G | Method for treating allergies using substituted pyrazoles |
| US20070117785A1 (en) * | 2000-08-14 | 2007-05-24 | Butler Christopher R | Substituted pyrazoles and methods of treatment with substituted pyrazoles |
| US7332494B2 (en) | 2000-08-14 | 2008-02-19 | Janssen Pharmaceutica, N.V. | Method for treating allergies using substituted pyrazoles |
| HK1052705B (en) * | 2000-08-14 | 2006-09-29 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted pyrazole |
| US6369032B1 (en) | 2000-09-06 | 2002-04-09 | Ortho-Mcneil Pharmaceutical, Inc. | Method for treating allergies |
| AU2001288730B2 (en) * | 2000-09-06 | 2006-01-19 | Ortho-Mcneil Pharmaceutical, Inc. | Method for treating allergies using substituted pyrazoles |
| RU2286343C2 (ru) * | 2001-08-10 | 2006-10-27 | Орто-Макнейл Фармасьютикал, Инк. | Замещенные пиразолы |
| JP2005528443A (ja) | 2002-05-30 | 2005-09-22 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｊａｋキナーゼおよびｃｄｋ２プロテインキナーゼのインヒビター |
| EP1526852A1 (en) * | 2002-07-25 | 2005-05-04 | Pharmacia Italia S.p.A. | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| EP2243781A1 (en) * | 2003-05-30 | 2010-10-27 | Vertex Pharmaceuticals, Inc. | Pyrazolopyridine derivatives as inhibitors of JAK and CDK2 protein kinases |
| ES2319539T3 (es) | 2003-09-17 | 2009-05-08 | Janssen Pharmaceutica Nv | Compuestos heterociclicos condensados como moduladores del receptor de serotonina. |
| JP2007506787A (ja) | 2003-09-23 | 2007-03-22 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼインヒビターとしてのピラゾロピロール誘導体 |
| KR100838692B1 (ko) | 2007-07-11 | 2008-06-16 | 한국화학연구원 | 7-(3′,4′-디알콕시페닐)-4,5,6,7-테트라히드로피라졸로[1,5-ａ]피리미딘 화합물, 이의 제조방법 및 이를 포함하는천식 및 만성폐쇄성 폐질환을 포함한 염증관련 질환,관절염, 아토피 피부염, 암 및 뇌질환의 치료 및 예방을위한 약제학적 조성물 |
| US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
| MX2014002968A (es) * | 2011-09-12 | 2014-07-09 | Sanofi Sa | 4,5,6,7 - tetrahidro - 1h - pirazolo [4,3 -c] piridinas sustituidas con indanilo, su uso como medicamento, y preparaciones farmaceuticas que las comprenden. |
| WO2013037389A1 (en) * | 2011-09-12 | 2013-03-21 | Sanofi | Indanyl-substituted 4,5,6,7-tetrahydro-1h-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them |
| AU2011376721B2 (en) * | 2011-09-16 | 2017-06-08 | Sanofi | Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them |
| BR112014006180A2 (pt) * | 2011-09-16 | 2017-04-11 | Sanofi Sa | 4, 5, 6, 7-tetraidro-1h-pirazol [4, 3-c] piridinas substituídas, seu uso como medicamento e preparações farmacêuticas que compreendem as mesmas |
| WO2016109684A2 (en) * | 2014-12-30 | 2016-07-07 | Novira Therapeutics, Inc. | Derivatives and methods of treating hepatitis b infections |
| JP7014736B2 (ja) * | 2016-05-24 | 2022-02-01 | ジェネンテック， インコーポレイテッド | がんの処置のためのピラゾロピリジン誘導体 |
| AU2017290755B2 (en) | 2016-06-29 | 2021-07-01 | Novira Therapeutics, Inc. | Diazepinone derivatives and their use in the treatment of hepatitis B infections |
| EP3478692B1 (en) | 2016-06-29 | 2020-06-17 | Novira Therapeutics Inc. | Oxadiazepinone derivatives and their use in the treatment of hepatitis b infections |
| US10562896B2 (en) | 2017-05-31 | 2020-02-18 | Chemocentryx, Inc. | 6-5 fused rings as C5a inhibitors |
| WO2019126424A1 (en) * | 2017-12-22 | 2019-06-27 | Chemocentryx, Inc. | DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3852279A (en) * | 1973-03-12 | 1974-12-03 | Squibb & Sons Inc | 7-substituted -3,3a,4,5,6,7-hexahydro-3-substituted-2h- pyrazolo (4,3-c)pyridines |
-
1983
- 1983-01-25 DK DK27383A patent/DK27383A/da not_active Application Discontinuation
- 1983-01-31 ZA ZA83628A patent/ZA83628B/xx unknown
- 1983-01-31 IL IL67785A patent/IL67785A0/xx unknown
- 1983-02-03 GR GR70399A patent/GR78080B/el unknown
- 1983-02-06 DE DE8383101109T patent/DE3373904D1/de not_active Expired
- 1983-02-06 EP EP83101109A patent/EP0086422B1/en not_active Expired
- 1983-02-06 AT AT83101109T patent/ATE30027T1/de not_active IP Right Cessation
- 1983-02-08 PH PH28489A patent/PH23645A/en unknown
- 1983-02-10 AU AU11305/83A patent/AU563591B2/en not_active Expired - Fee Related
- 1983-02-15 US US06/466,701 patent/US4500525A/en not_active Expired - Fee Related
- 1983-02-15 KR KR1019830000609A patent/KR900006853B1/ko not_active Expired
- 1983-02-16 NZ NZ203302A patent/NZ203302A/en unknown
- 1983-02-16 ES ES519832A patent/ES8500273A1/es not_active Expired
- 1983-02-16 CA CA000421751A patent/CA1225646A/en not_active Expired
- 1983-02-16 IE IE328/83A patent/IE55156B1/en not_active IP Right Cessation
- 1983-02-17 JP JP58023893A patent/JPS58152885A/ja active Granted
-
1984
- 1984-04-27 ES ES531980A patent/ES8507546A1/es not_active Expired
- 1984-04-27 ES ES531981A patent/ES531981A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| AU563591B2 (en) | 1987-07-16 |
| EP0086422B1 (en) | 1987-09-30 |
| ES531980A0 (es) | 1985-09-01 |
| DK27383D0 (da) | 1983-01-25 |
| DE3373904D1 (en) | 1987-11-05 |
| EP0086422A2 (en) | 1983-08-24 |
| ES8507546A1 (es) | 1985-09-01 |
| IL67785A0 (en) | 1983-05-15 |
| EP0086422A3 (en) | 1984-03-28 |
| GR78080B (https=) | 1984-09-26 |
| ES8507547A1 (es) | 1985-09-01 |
| KR900006853B1 (ko) | 1990-09-22 |
| CA1225646A (en) | 1987-08-18 |
| PH23645A (en) | 1989-09-27 |
| ES519832A0 (es) | 1984-10-01 |
| KR840003636A (ko) | 1984-09-15 |
| NZ203302A (en) | 1986-08-08 |
| JPS58152885A (ja) | 1983-09-10 |
| ATE30027T1 (de) | 1987-10-15 |
| ES531981A0 (es) | 1985-09-01 |
| JPH0412269B2 (https=) | 1992-03-04 |
| AU1130583A (en) | 1983-08-25 |
| IE830328L (en) | 1983-08-17 |
| ES8500273A1 (es) | 1984-10-01 |
| IE55156B1 (en) | 1990-06-20 |
| ZA83628B (en) | 1983-12-28 |
| US4500525A (en) | 1985-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |