DK2734547T3 - Anvendelse af c-fms-antistoffer - Google Patents
Anvendelse af c-fms-antistoffer Download PDFInfo
- Publication number
- DK2734547T3 DK2734547T3 DK12735555.0T DK12735555T DK2734547T3 DK 2734547 T3 DK2734547 T3 DK 2734547T3 DK 12735555 T DK12735555 T DK 12735555T DK 2734547 T3 DK2734547 T3 DK 2734547T3
- Authority
- DK
- Denmark
- Prior art keywords
- pain
- leu
- ser
- fms
- pro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/249—Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Claims (7)
1. Antagonist af c-Fms til anvendelse i behandling af osteoarthritis eller smerte, hvor antagonisten er et antistof, der er specifikt for M-CSF, c-FMS eller IL-34.
2. Antagonist ifølge krav 1 til anvendelse ifølge krav 1, hvor smerten er postoperativ smerte.
3. Antagonist ifølge krav 1 til anvendelse ifølge krav 1, hvor smerten skyldes knoglecancer.
4. Antagonist ifølge krav 1 til anvendelse ifølge krav 1, hvor smerten skyldes rheumatoid arthritis.
5. Antagonist ifølge krav 1 til anvendelse ifølge krav 1, hvor smerten skyldes osteoarthritis.
6. Antagonist ifølge krav 1 til anvendelse ifølge krav 1, hvor smerten skyldes inflammation.
7. Antagonist ifølge et hvilket som helst af de foregående krav til anvendelse ifølge krav 1, hvor antagonisten anvendes til et menneske.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161508717P | 2011-07-18 | 2011-07-18 | |
EP11174305 | 2011-07-18 | ||
PCT/EP2012/063998 WO2013011021A1 (en) | 2011-07-18 | 2012-07-17 | Use of c-fms antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2734547T3 true DK2734547T3 (da) | 2017-04-03 |
Family
ID=47557687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12735555.0T DK2734547T3 (da) | 2011-07-18 | 2012-07-17 | Anvendelse af c-fms-antistoffer |
Country Status (8)
Country | Link |
---|---|
US (3) | US9243066B2 (da) |
EP (1) | EP2734547B1 (da) |
JP (2) | JP2014520873A (da) |
AU (1) | AU2012285875B2 (da) |
CA (1) | CA2841013C (da) |
DK (1) | DK2734547T3 (da) |
ES (1) | ES2618828T3 (da) |
WO (1) | WO2013011021A1 (da) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2722300T3 (es) | 2009-12-10 | 2019-08-09 | Hoffmann La Roche | Anticuerpos que se unen preferentemente al dominio extracelular 4 de CSF1R y su uso |
CN104159921B (zh) | 2011-12-15 | 2018-05-04 | 霍夫曼-拉罗奇有限公司 | 针对人csf-1r的抗体及其用途 |
AR095882A1 (es) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
WO2014189832A1 (en) * | 2013-05-22 | 2014-11-27 | Albert Einstein College Of Medicine Of Yeshiva University | Il-34 receptor assays and uses thereof |
AR097584A1 (es) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
JP6769948B2 (ja) * | 2014-07-17 | 2020-10-14 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 移植拒絶の予防及び自己免疫疾患の治療に使用するための単離されたインターロイキン−34ポリペプチド |
EP3204050A4 (en) * | 2014-10-09 | 2018-04-04 | The Regents of The University of California | Targeted disruption of a csf1-dap12 pathway member gene for the treatment of neuropathic pain |
JP6621252B2 (ja) * | 2015-06-17 | 2019-12-18 | 国立大学法人北海道大学 | 治療耐性がんに対する治療耐性低減剤 |
MA44309A (fr) * | 2015-11-25 | 2018-10-03 | Nogra Pharma Ltd | Oligonucléotides antisens il-34 et leurs procédés d'utilisation |
WO2018036852A1 (en) | 2016-08-25 | 2018-03-01 | F. Hoffmann-La Roche Ag | Intermittent dosing of an anti-csf-1r antibody in combination with macrophage activating agent |
EP3558360A1 (en) | 2016-12-22 | 2019-10-30 | F. Hoffmann-La Roche AG | Treatment of tumors with an anti-csf-1r antibody in combination with an anti-pd-l1 antibody after failure of anti-pd-l1/pd1 treatment |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3001969B2 (ja) | 1989-02-10 | 2000-01-24 | カイロン コーポレイション | 中和配座エピトープを認識するm―csfモノクローナル抗体 |
WO1997008320A1 (en) | 1995-08-18 | 1997-03-06 | Morphosys Gesellschaft Für Proteinoptimierung Mbh | Protein/(poly)peptide libraries |
JP4891477B2 (ja) | 1997-10-02 | 2012-03-07 | マックス−プランク−ゲゼルシャフト ツール フォーデルング デル ヴィッセンシャフテン エー.ヴェー. | 血管新生及び/または既存細動脈網から側枝動脈及び/または他の動脈の発達の調節に関する方法 |
AU783063B2 (en) | 1999-10-28 | 2005-09-22 | Seyedhossein Aharinejad | Use of CSF-1 inhibitors |
US7108852B2 (en) * | 2000-03-20 | 2006-09-19 | Warner-Lambert Company Llc | Methods of treating inflammation using antibodies to M-CSF |
PL372138A1 (en) | 2001-10-15 | 2005-07-11 | Chiron Corporation | Treatment of sepsis by low dose administration of tissue factor pathway inhibitor (tfpi) |
SE0200667D0 (sv) | 2002-03-05 | 2002-03-05 | A & Science Invest Ab | Novel use of cytokine inhibitors |
US20110091451A1 (en) | 2002-11-15 | 2011-04-21 | Kavanaugh William M | Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis |
AU2003291002A1 (en) | 2002-11-15 | 2004-06-15 | Chiron Corporation | Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis |
AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
GB0325836D0 (en) | 2003-11-05 | 2003-12-10 | Celltech R&D Ltd | Biological products |
PT2311873T (pt) | 2004-01-07 | 2018-11-20 | Novartis Vaccines & Diagnostics Inc | Anticorpo monoclonal específico para m-csf e respetivos usos |
CA2600601A1 (en) | 2005-03-08 | 2006-09-14 | Pharmacia & Upjohn Company Llc | Anti-m-csf antibody compositions having reduced levels of endotoxin |
WO2006096490A2 (en) | 2005-03-08 | 2006-09-14 | Pharmacia & Upjohn Company Llc | ANTI-MAdCAM ANTIBODY COMPOSITIONS |
AU2006270057A1 (en) | 2005-07-18 | 2007-01-25 | Trustees Of Boston University | Method to inhibit proliferation and growth of metastases |
US8652469B2 (en) | 2005-07-28 | 2014-02-18 | Novartis Ag | M-CSF-specific monoclonal antibody and uses thereof |
US20080233118A1 (en) | 2005-07-28 | 2008-09-25 | Novartis Ag | Uses Of Antibody To M-Csf |
US20090181008A1 (en) | 2005-11-10 | 2009-07-16 | Satoris, Inc. | Methods of treating alzheimer's disease |
KR20080083187A (ko) | 2006-01-05 | 2008-09-16 | 노바르티스아게 | 암 전이 및 암 전이와 관련된 골 소실의 예방 및 치료 방법 |
WO2008124129A2 (en) | 2007-04-09 | 2008-10-16 | University Of Massachusetts | Treating hiv with a m-csf effector kinase inhibitor like imatinib |
BRPI0815368A2 (pt) * | 2007-08-21 | 2015-02-10 | Amgen Inc | "proteinas c-fms humanas a antigeno" |
CN101801379A (zh) * | 2007-10-18 | 2010-08-11 | 诺瓦提斯公司 | 治疗癌症和骨疾病的csf-1r抑制剂 |
WO2009075344A1 (ja) | 2007-12-12 | 2009-06-18 | Japan As Represented By Director General Of Agency Of National Cancer Center | M-csf受容体を分子標的とするmll白血病及びmoz白血病治療剤、およびその利用 |
US8470977B2 (en) | 2008-03-14 | 2013-06-25 | Transgene S.A. | Antibody against the CSF-1R |
CN102702358B (zh) * | 2008-03-14 | 2016-02-17 | 天士力创世杰(天津)生物制药有限公司 | 针对csf-1r的抗体 |
JP2011530520A (ja) | 2008-08-05 | 2011-12-22 | ユニバーシティー オブ サウス フロリダ | 認知障害を治療する方法 |
GB0910833D0 (en) * | 2009-06-23 | 2009-08-05 | Univ Edinburgh | Avian genes |
ES2722300T3 (es) | 2009-12-10 | 2019-08-09 | Hoffmann La Roche | Anticuerpos que se unen preferentemente al dominio extracelular 4 de CSF1R y su uso |
US9169323B2 (en) | 2010-03-05 | 2015-10-27 | Hoffmann-La Roche Inc. | Antibodies against human CSF-1R |
RU2617966C2 (ru) | 2010-03-05 | 2017-04-28 | Ф.Хоффманн-Ля Рош Аг | Антитела против csf-1r человека и их применение |
WO2011140249A2 (en) | 2010-05-04 | 2011-11-10 | Five Prime Therapeutics, Inc. | Antibodies that bind csf1r |
CN104271599A (zh) | 2011-11-08 | 2015-01-07 | 辉瑞公司 | 使用抗m-csf抗体治疗炎性疾病的方法 |
-
2012
- 2012-07-17 JP JP2014520640A patent/JP2014520873A/ja active Pending
- 2012-07-17 AU AU2012285875A patent/AU2012285875B2/en active Active
- 2012-07-17 ES ES12735555.0T patent/ES2618828T3/es active Active
- 2012-07-17 DK DK12735555.0T patent/DK2734547T3/da active
- 2012-07-17 EP EP12735555.0A patent/EP2734547B1/en active Active
- 2012-07-17 US US14/126,878 patent/US9243066B2/en active Active
- 2012-07-17 CA CA2841013A patent/CA2841013C/en active Active
- 2012-07-17 WO PCT/EP2012/063998 patent/WO2013011021A1/en active Application Filing
-
2015
- 2015-12-16 US US14/970,578 patent/US10005840B2/en active Active
-
2017
- 2017-01-04 JP JP2017000058A patent/JP6313481B2/ja active Active
-
2018
- 2018-04-17 US US15/954,942 patent/US20180237531A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US10005840B2 (en) | 2018-06-26 |
JP6313481B2 (ja) | 2018-04-18 |
US20160185867A1 (en) | 2016-06-30 |
JP2014520873A (ja) | 2014-08-25 |
AU2012285875B2 (en) | 2016-11-10 |
US20180237531A1 (en) | 2018-08-23 |
EP2734547B1 (en) | 2016-12-21 |
EP2734547A1 (en) | 2014-05-28 |
ES2618828T3 (es) | 2017-06-22 |
WO2013011021A1 (en) | 2013-01-24 |
US9243066B2 (en) | 2016-01-26 |
JP2017095484A (ja) | 2017-06-01 |
CA2841013A1 (en) | 2013-01-24 |
AU2012285875A8 (en) | 2016-11-03 |
CA2841013C (en) | 2020-04-21 |
US20140205608A1 (en) | 2014-07-24 |
AU2012285875A1 (en) | 2014-01-16 |
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