DK2714647T3 - Biphenyl derivatives useful as Glucagon receptor antagonists - Google Patents

Biphenyl derivatives useful as Glucagon receptor antagonists Download PDF

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Publication number
DK2714647T3
DK2714647T3 DK12724508.2T DK12724508T DK2714647T3 DK 2714647 T3 DK2714647 T3 DK 2714647T3 DK 12724508 T DK12724508 T DK 12724508T DK 2714647 T3 DK2714647 T3 DK 2714647T3
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DK
Denmark
Prior art keywords
mmol
formula
compound
biphenyl
methyl
Prior art date
Application number
DK12724508.2T
Other languages
Danish (da)
English (en)
Inventor
Devraj Chakravarty
Michael N Greco
Brian Shook
Guozhang Xu
Rui Zhang
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK2714647T3 publication Critical patent/DK2714647T3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK12724508.2T 2011-05-23 2012-05-23 Biphenyl derivatives useful as Glucagon receptor antagonists DK2714647T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161488848P 2011-05-23 2011-05-23
PCT/US2012/039173 WO2012162409A1 (en) 2011-05-23 2012-05-23 Biphenyl derivatives useful as glucagon receptor antagonists

Publications (1)

Publication Number Publication Date
DK2714647T3 true DK2714647T3 (en) 2015-05-26

Family

ID=46178850

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12724508.2T DK2714647T3 (en) 2011-05-23 2012-05-23 Biphenyl derivatives useful as Glucagon receptor antagonists

Country Status (12)

Country Link
US (1) US9045389B2 (es)
EP (1) EP2714647B1 (es)
JP (1) JP2014520093A (es)
CN (1) CN103547563B (es)
AU (1) AU2012258773A1 (es)
CA (1) CA2837088A1 (es)
DK (1) DK2714647T3 (es)
ES (1) ES2544104T3 (es)
MX (1) MX2013013732A (es)
PL (1) PL2714647T3 (es)
PT (1) PT2714647E (es)
WO (1) WO2012162409A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10442263B2 (en) * 2017-04-03 2019-10-15 Robby Gordon Low suspension arm strut coupling

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0802191A4 (en) 1995-10-13 2001-08-01 Otsuka Kagaku Kk PYRAZOLE DERIVATIVES AND INSECTICIDE COMPOSITIONS CONTAINING SUCH DERIVATIVES AS ACTIVE INGREDIENTS
CN1356977A (zh) 1999-05-17 2002-07-03 诺沃挪第克公司 胰高血糖素拮抗剂/反向激动剂
WO2003048109A1 (en) * 2001-12-03 2003-06-12 Novo Nordisk A/S Novel glucagon antagonists
AU2003291959A1 (en) 2002-12-20 2004-07-14 Novo Nordisk A/S Novel glucagon antagonists
JP2007191461A (ja) * 2005-05-23 2007-08-02 Japan Tobacco Inc ピラゾール化合物及びそれらピラゾール化合物を含んでなる糖尿病治療薬
KR20080047410A (ko) 2005-08-23 2008-05-28 아이알엠 엘엘씨 면역억제제 화합물 및 조성물
JP5107253B2 (ja) * 2005-11-17 2012-12-26 イーライ リリー アンド カンパニー グルカゴン受容体アンタゴニスト、並びにその調製及び治療への使用
CA2645639A1 (en) * 2006-03-23 2007-10-04 Merck & Co. Inc. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
BRPI0821274A2 (pt) * 2007-12-20 2017-06-13 Astrazeneca Ab composto ou um sal, ou pró-droga farmaceuticamente aceitável do mesmo, uso do mesmo, método para tratar uma doença em um animal de sangue quente, e, composição farmacêutica
CN103547570A (zh) 2011-05-23 2014-01-29 詹森药业有限公司 可用作胰高血糖素受体拮抗剂的吡啶甲酰胺基-丙酸衍生物

Also Published As

Publication number Publication date
PT2714647E (pt) 2015-09-02
AU2012258773A1 (en) 2013-11-14
JP2014520093A (ja) 2014-08-21
US9045389B2 (en) 2015-06-02
EP2714647B1 (en) 2015-04-29
ES2544104T3 (es) 2015-08-27
EP2714647A1 (en) 2014-04-09
CN103547563B (zh) 2016-03-23
PL2714647T3 (pl) 2015-09-30
US20120302641A1 (en) 2012-11-29
MX2013013732A (es) 2014-02-27
CN103547563A (zh) 2014-01-29
WO2012162409A1 (en) 2012-11-29
CA2837088A1 (en) 2012-11-29

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