DK2688614T3 - Dosisindstillingsmekanisme og injektionsanordning - Google Patents

Dosisindstillingsmekanisme og injektionsanordning Download PDF

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DK2688614T3
DK2688614T3 DK12711382T DK12711382T DK2688614T3 DK 2688614 T3 DK2688614 T3 DK 2688614T3 DK 12711382 T DK12711382 T DK 12711382T DK 12711382 T DK12711382 T DK 12711382T DK 2688614 T3 DK2688614 T3 DK 2688614T3
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dose setting
coupling
clicker
clutch
dose
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DK12711382T
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English (en)
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David Aubrey Plumptre
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Sanofi Aventis Deutschland
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A61M5/31528—Dosing by means of rotational movements, e.g. screw-thread mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31555—Mechanically operated dose setting member by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (15)

1. Dosisindstillingsmekanisme til en lægemiddelfremføringsanordning, hvilken mekanisme omfatter: et dosisindstillingselement (3) , et drivelement (4), et koblingselement (5) , der er placeret mellem dosisindstillingselementet (3) og drivelementet (4), hvilket koblingselement (5) er aksialt bevægeligt i forhold til dosisindstillingselementet (3) og til drivelementet (4) og er rotationsfikseret til drivelementet (4) til tilvejebringelse af en første kobling (5a, 5b) til rotationskobling og afkobling af dosisindstillingselementet (3) og drivelementet (4) , en klikker (6), der omfatter en første klikkerbestanddel (6') og en anden klikkerbestanddel (6"), der er aksialt bevægelige i forhold til hinanden til frembringelse af et føleligt og/eller hørligt feedback under relativ rotationsbevægelse der imellem, hvor den første klikkerbestanddel (6') er aksialt bevægelig i forhold til drivelementet (4) til tilvejebringelse af en anden kobling (10, 11) til rotationskobling og afkobling af drivelementet (4) og den første klikkerbestanddel (6'), hvor den første kobling (5a, 5b) og den anden kobling (9, 11) er udformet og tilpasset til hinanden, således at det på et hvilket som helst tidspunkt under betjening gælder, at enten den første kobling (5a, 5b) rotationskobler dosisindstillingselementet (3) og drivelementet (4), og/eller den anden kobling (9, 11) rotationskobler drivelementet (4) og den første klikkerbestanddel (6').
2. Dosisindstillingsmekanisme ifølge krav 1, der er kendetegnet ved, at den første klikkerbestanddel (6') følger den aksiale bevægelse af koblingselementet (5) under den aksiale bevægelse af koblingselementet (5) til rotationsafkobling af den første kobling (5a, 5b) mellem drivelementet (4) og dosisindstillingselementet (3), hvor den anden kobling (10, 11) rotationskobler drivelementet (4) og den første klikkerbestanddel (6'), før den første kobling (5a, 5b) rotations-afkobler dosisindstillingselementet (3) og drivelementet (4).
3. Dosisindstillingsmekanisme ifølge krav 1 eller 2, der er kendetegnet ved, at koblingselementet (5) følger den aksiale bevægelse af den første klikkerbestanddel (6') under den aksiale bevægelse af den første klikkerbestanddel (6') til rotations-afkobling af drivelementet (4) og den første klikkerbestanddel (6'), hvor den første kobling (5a, 5b) rotationskobler dosisindstillingselementet (3) og drivelementet (4) , før den anden kobling (10, 11) rotations-af kobler drivelementet (4) og den første klikkerbestanddel (6') .
4. Dosisindstillingsmekanisme ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den anden kobling omfatter første koblingstænder eller noter (10), der er tilvejebragt på drivelementet (4), og tilsvarende anden koblingstænder eller noter (11), der er tilvejebragt på den første klikkerbestanddel (6').
5. Dosisindstillingsmekanisme ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den første kobling omfatter første koblingstænder eller noter, der er tilvejebragt på dosisindstillingselementet (3), og tilsvarende anden koblingstænder (5b) eller noter, der er tilvejebragt på et koblingselement (5).
6. Dosisindstillingsmekanisme ifølge krav 5, der er kendetegnet ved, at den første klikkerbestanddel (6') er anbragt mellem koblingselementet (5) af den første kobling og den anden klikkerbestanddel (6").
7. Dosisindstillingsmekanisme ifølge krav 5 eller 6, der er kendetegnet ved, at den første klikkerbestanddel (6') omfatter første koblingstænder eller noter (8a), og koblingselementet (5) omfatter tilsvarende anden koblingstænder eller noter (8b) til rotations-indjustering af den første klikkerbestanddel (6') og koblingselementet (5).
8. Dosisindstillingsmekanisme ifølge et hvilket som helst af ovennævnte krav, der yderligere omfatter et huselement (2) , der er kendetegnet ved, at den første klikkerbestanddel (6') er permanent rotationskoblet til huselementet (2), og den anden klikkerbestanddel (6") er permanent rotationskoblet til drivelementet (4).
9. Dosisindstillingsmekanisme ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at der er tilvejebragt en klikkerf j eder (7), der virker på den anden klikkerbestanddel (6").
10. Dosisindstillingsmekanisme ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at dosisindstillingselementet omfatter en dosisskalamanchet eller talmanchet (3) , der kan rotere i forhold til huselementet (2) til indstilling af en dosis, og at drivelementet omfatter en drivmanchet (4), der er bevægelig i en første aksial retning i forhold til huselementet (2) under dosisindstilling, og der er bevægelig i en anden aksial retning i forhold til huselementet (2) under dosisdispensering, hvilken anden aksiale retning er modsat den første aksiale retning.
11. Dosisindstillingsmekanisme ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at koblingselementet (5) rotationskobler dosisindstillingselementet (3) og drivelementet (4) under dosisindstilling og rotations-afkobler dosisindstillingselementet (3) og drivelementet (4) under dosisdispensering.
12. Dosisindstillingsmekanisme ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den første klikkerbestanddel (6') og den anden klikkerbestanddel (6") kan rotere i forhold til hinanden under dosisindstilling og er rotations-låst sammen under dosisdispensering.
13. Dosisindstillingsmekanisme ifølge et hvilket som helst af ovennævnte krav, der er kendetegnet ved, at den anden klikkerbestanddel (6") kan bevæge sig frit aksialt i forhold til drivelementet (4), men er rotations-låst til drivelementet (4) .
14. Dosisindstillingsmekanisme ifølge et hvilket som helst af ovennævnte krav, der yderligere omfatter en klikkerfjeder (7), der påvirker den første klikkerbestanddel (6') og den anden klikkerbestanddel (6") sammen, påvirker den første klikkerbestanddel (6') og koblingselementet (5) sammen, påvirker dosisindstillingselementet (1) og koblingselementet (5) til tilkobling, påvirker to dele af drivelementet (4), der omfatter en distal og proksimal drivelementdel, ind i en koblet position, tilvejebringer en kraft under dosisdispensering, der driver den distale (forreste) del af drivelementet (4) fremad, og/eller modstår afkobling af den distale og proksimale drivelementdel med en kraft i størrelsesordenen som tyngdekraften.
15. Injektionsanordning, der omfatter en dosisindstillingsmekanisme ifølge et hvilket som helst af ovennævnte krav og et medikament, der fortrinsvis er indeholdt i en patron.
DK12711382T 2011-03-25 2012-03-22 Dosisindstillingsmekanisme og injektionsanordning DK2688614T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11159756 2011-03-25
PCT/EP2012/055054 WO2012130703A1 (en) 2011-03-25 2012-03-22 Dose setting mechanism and injection device

Publications (1)

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DK2688614T3 true DK2688614T3 (da) 2015-04-20

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US (1) US9144649B2 (da)
EP (1) EP2688614B1 (da)
JP (1) JP6150788B2 (da)
KR (1) KR101961085B1 (da)
CN (1) CN103561801B (da)
AR (1) AR085523A1 (da)
AU (1) AU2012234467B2 (da)
BR (1) BR112013023893B1 (da)
CA (1) CA2830022C (da)
DK (1) DK2688614T3 (da)
ES (1) ES2534081T3 (da)
HK (1) HK1189526A1 (da)
IL (1) IL228253B (da)
MX (1) MX336984B (da)
MY (1) MY164000A (da)
PT (1) PT2688614E (da)
RU (1) RU2606451C2 (da)
SG (1) SG193282A1 (da)
TW (1) TWI600446B (da)
WO (1) WO2012130703A1 (da)
ZA (1) ZA201306582B (da)

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Publication number Priority date Publication date Assignee Title
CA2829497A1 (en) 2011-03-24 2012-09-27 Sanofi-Aventis Deutschland Gmbh Device and method for detecting an actuation action performable with a medical device
US10792436B2 (en) 2013-11-22 2020-10-06 Sanofi-Aventis Deutschland Gmbh Spring assisted drug delivery device
EP3058970A1 (en) 2015-02-19 2016-08-24 Sanofi-Aventis Deutschland GmbH Data collection device for attachment to an injection device
JP6444219B2 (ja) * 2015-02-27 2018-12-26 Ｊｘｔｇエネルギー株式会社 ギヤ油用潤滑油組成物
EP3307357B2 (en) * 2015-06-09 2023-06-07 Sanofi-Aventis Deutschland GmbH Data collection apparatus for attachment to an injection device
US20170107417A1 (en) * 2015-06-30 2017-04-20 Exxonmobil Chemical Patents Inc. Lubricant Compositions and Methods of Making and Using Same

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US5279586A (en) * 1992-02-04 1994-01-18 Becton, Dickinson And Company Reusable medication delivery pen
ATE355093T1 (de) * 2001-05-16 2006-03-15 Lilly Co Eli Arzneimitteleinspritzvorrichtung mit rückstellung erleichternder antriebsanordnung
GB0304823D0 (en) * 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
US9205197B2 (en) * 2003-03-03 2015-12-08 Sanofi-Aventis Deutschland Gmbh Drug delivery device dose setting mechanism
PL1799287T3 (pl) * 2004-10-04 2014-03-31 Sanofi Aventis Deutschland Mechanizm napędowy dla urządzenia do dostarczania leku
EP2073871B1 (en) * 2006-09-29 2013-03-20 Novo Nordisk A/S An injection device with electronic detecting means
US9623187B2 (en) * 2009-06-01 2017-04-18 Sanofi-Aventis Deutschland Gmbh Resettable drug delivery device
JP2012531285A (ja) * 2009-06-30 2012-12-10 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 駆動機構及び薬物送達デバイス

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ZA201306582B (en) 2014-05-28
RU2013147640A (ru) 2015-04-27
EP2688614B1 (en) 2015-01-14
CN103561801B (zh) 2015-08-05
BR112013023893A2 (pt) 2016-12-13
MX336984B (es) 2016-02-09
KR101961085B1 (ko) 2019-03-25
AU2012234467B2 (en) 2015-11-26
SG193282A1 (en) 2013-10-30
ES2534081T3 (es) 2015-04-17
KR20140019813A (ko) 2014-02-17
JP6150788B2 (ja) 2017-06-21
JP2014513598A (ja) 2014-06-05
US20140018745A1 (en) 2014-01-16
MY164000A (en) 2017-11-15
AU2012234467A1 (en) 2013-10-10
IL228253B (en) 2018-04-30
RU2606451C2 (ru) 2017-01-10
TWI600446B (zh) 2017-10-01
AR085523A1 (es) 2013-10-09
MX2013010708A (es) 2013-10-01
TW201249495A (en) 2012-12-16
WO2012130703A1 (en) 2012-10-04
US9144649B2 (en) 2015-09-29
HK1189526A1 (en) 2014-06-13
CA2830022A1 (en) 2012-10-04
PT2688614E (pt) 2015-04-15
EP2688614A1 (en) 2014-01-29
NZ615854A (en) 2014-07-25
BR112013023893B1 (pt) 2021-01-05
CA2830022C (en) 2019-02-19
CN103561801A (zh) 2014-02-05

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