DK2656850T3 - Oligonucleotides for the treatment or alleviation of EDEMA - Google Patents

Oligonucleotides for the treatment or alleviation of EDEMA Download PDF

Info

Publication number
DK2656850T3
DK2656850T3 DK13177620.5T DK13177620T DK2656850T3 DK 2656850 T3 DK2656850 T3 DK 2656850T3 DK 13177620 T DK13177620 T DK 13177620T DK 2656850 T3 DK2656850 T3 DK 2656850T3
Authority
DK
Denmark
Prior art keywords
oligonucleotide
edema
reduction
treatment
administration
Prior art date
Application number
DK13177620.5T
Other languages
Danish (da)
English (en)
Inventor
Arezou Zargari
Lars-Göran Axelsson
Ann-Kristin Spiik
Nikolai Kouznetsov
Original Assignee
Index Pharmaceuticals Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Index Pharmaceuticals Ab filed Critical Index Pharmaceuticals Ab
Application granted granted Critical
Publication of DK2656850T3 publication Critical patent/DK2656850T3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/17Immunomodulatory nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
DK13177620.5T 2007-10-05 2008-10-02 Oligonucleotides for the treatment or alleviation of EDEMA DK2656850T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97801007P 2007-10-05 2007-10-05
EP08835591.2A EP2207555B1 (en) 2007-10-05 2008-10-02 Oligonucleotides for the treatment or alleviation of edema

Publications (1)

Publication Number Publication Date
DK2656850T3 true DK2656850T3 (en) 2016-11-28

Family

ID=40526448

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13177620.5T DK2656850T3 (en) 2007-10-05 2008-10-02 Oligonucleotides for the treatment or alleviation of EDEMA

Country Status (7)

Country Link
US (1) US8410068B2 (https=)
EP (2) EP2207555B1 (https=)
JP (2) JP5547637B2 (https=)
CA (1) CA2738070C (https=)
DK (1) DK2656850T3 (https=)
ES (1) ES2600919T3 (https=)
WO (1) WO2009045145A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2573176B1 (en) * 2007-05-04 2016-04-06 InDex Pharmaceuticals AB Tumour growth inhibitory compounds and methods of their use
EP2288702A4 (en) * 2008-06-18 2011-06-29 Index Pharmaceuticals Ab COMBINATION THERAPIES AGAINST CANCER
TWI378933B (en) 2008-10-14 2012-12-11 Daiichi Sankyo Co Ltd Morpholinopurine derivatives
US8637479B2 (en) 2008-11-04 2014-01-28 Index Pharmaceuticals Ab Compounds and methods for the treatment of inflammatory diseases of the CNS
EP3165607B1 (en) * 2010-12-21 2021-04-07 InDex Pharmaceuticals AB Biologically active oligonucleotides capable of modulating the immune system
WO2012084991A1 (en) * 2010-12-21 2012-06-28 Index Pharmaceuticals Ab Biologically active oligonucleotides capable of modulating the immune system ii
US10975033B2 (en) * 2011-07-12 2021-04-13 Vanderbilt University Methods for treating inflammation and hypertension with γ-ketoaldehyde skavengers
GB201707501D0 (en) * 2017-05-10 2017-06-21 Index Pharmaceuticals Ab New therapy 2

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610289A (en) * 1990-07-27 1997-03-11 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogues
DE69232722T2 (de) * 1991-08-23 2002-12-05 The Board Of Regents Of The University Of Nebraska, Lincoln Verfahren und zusammensetzungen für zelluläre reprogrammierung
US7517644B1 (en) * 1991-08-23 2009-04-14 Larry J. Smith Method and compositions for cellular reprogramming
US5968826A (en) * 1998-10-05 1999-10-19 Isis Pharmaceuticals Inc. Antisense inhibition of integrin α4 expression
US6610836B1 (en) * 1999-01-29 2003-08-26 Genome Therapeutics Corporation Nucleic acid amino acid sequences relating to Klebsiella pneumoniae for diagnostics and therapeutics
US20110131679A2 (en) * 2000-04-19 2011-06-02 Thomas La Rosa Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
WO2002012894A1 (en) * 2000-08-09 2002-02-14 Mount Sinai School Of Medicine Kruppel-like factor 6 (klf6), a tumorsuppressor protein, and dia gnostics, therapeutics, and screening based on this protein
US7630836B2 (en) * 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
AU2003303305A1 (en) * 2002-10-02 2004-09-30 Nuvelo,Inc. Novel nucleic acids and polypeptides
CN1711361A (zh) * 2002-10-15 2005-12-21 诺瓦提斯公司 预测药物治疗副效应水肿的方法
JP2004166699A (ja) * 2002-11-06 2004-06-17 Takeda Chem Ind Ltd 抗利尿剤
US7250496B2 (en) * 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
US8227193B2 (en) * 2003-10-01 2012-07-24 The Regents Of The University Of California Compositions and methods for gene expression
US7374927B2 (en) 2004-05-03 2008-05-20 Affymetrix, Inc. Methods of analysis of degraded nucleic acid samples
PL2179737T3 (pl) * 2005-07-01 2014-01-31 Index Pharmaceuticals Ab Sposób do modulowania wrażliwości na steroidy
AU2006278282A1 (en) * 2005-08-09 2007-02-15 University Of Virginia Patent Foundation Methods and compositions for inhibition of vascular permeablility
EP2573176B1 (en) * 2007-05-04 2016-04-06 InDex Pharmaceuticals AB Tumour growth inhibitory compounds and methods of their use

Also Published As

Publication number Publication date
JP2014204722A (ja) 2014-10-30
EP2207555A4 (en) 2010-11-24
WO2009045145A1 (en) 2009-04-09
EP2656850B1 (en) 2016-07-27
EP2656850A2 (en) 2013-10-30
JP5914567B2 (ja) 2016-05-11
US20100240736A1 (en) 2010-09-23
EP2207555B1 (en) 2013-07-24
JP5547637B2 (ja) 2014-07-16
EP2207555A1 (en) 2010-07-21
JP2010539974A (ja) 2010-12-24
CA2738070C (en) 2018-03-20
ES2600919T3 (es) 2017-02-13
EP2656850A3 (en) 2014-02-12
CA2738070A1 (en) 2009-04-09
US8410068B2 (en) 2013-04-02

Similar Documents

Publication Publication Date Title
DK2656850T3 (en) Oligonucleotides for the treatment or alleviation of EDEMA
RU2712511C2 (ru) Миметики mir-29 и пути их применения
JP2015518712A (ja) Mecp2発現を調節するための組成物及び方法
JP2015523855A (ja) Apoa1及びabca1発現を調節するための組成物及び方法
JP2015518711A (ja) Bdnf発現を調節するための組成物及び方法
JP2015523854A (ja) Smn遺伝子ファミリー発現を調節するための組成物及び方法
EP3718561A1 (en) Therapeutic agent for inflammatory bowel disease
JP2015518713A (ja) Utrn発現を調節するための組成物及び方法
JP2015523853A (ja) Atp2a2発現を調節するための組成物及び方法
JP2015519057A (ja) Pten発現を調節するための組成物及び方法
AU2009302468A1 (en) Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto
CN118076736A (zh) 用于治疗与pcsk9相关疾病的靶向寡核苷酸
ES2464731T3 (es) Compuestos y procedimientos para reducir el reclutamiento y/o migración de células polimorfonucleares
CN118401665A (zh) 具有高稳定性和基因沉默活性的小干扰rna分子的修饰模式
CN104083761A (zh) microRNA-101抑制剂在制备预防或治疗骨关节炎药物中的应用
JP7788561B2 (ja) アンチセンスオリゴヌクレオチド及びその使用
EP4176887B1 (en) Pharmaceutical composition for prevention or treatment of inflammatory bowel disease comprising organoid and anti-inflammatory agent
JP3953552B2 (ja) 転写因子ap−1の拮抗的阻害剤
US20260103712A1 (en) Anti-fibrotic microrna composition
CN115381950B (zh) Rab 35或其下游调控分子在治疗骨折后慢性疼痛中的应用
JP2025538360A (ja) 阻害性核酸およびその使用方法
KR20250136380A (ko) 감염 질환을 치료하기 위한 압타머 및 비타민 c 복합체의 용도