JP5547637B2 - 浮腫を治療または軽減するための新規な化合物およびその使用方法 - Google Patents

浮腫を治療または軽減するための新規な化合物およびその使用方法 Download PDF

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JP5547637B2
JP5547637B2 JP2010527904A JP2010527904A JP5547637B2 JP 5547637 B2 JP5547637 B2 JP 5547637B2 JP 2010527904 A JP2010527904 A JP 2010527904A JP 2010527904 A JP2010527904 A JP 2010527904A JP 5547637 B2 JP5547637 B2 JP 5547637B2
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edema
oligonucleotide compound
oligonucleotide
treatment
isolated
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JP2010539974A5 (https=
JP2010539974A (ja
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ザルガリ，アレゾウ
アクセレッソン，ラース−ヨラン
スピーク，アン−クリスティン
コウズネットソフ，ニコライ
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インデックス・ファーマシューティカルズ・アクチエボラーグ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Biotechnology (AREA)
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  • Wood Science & Technology (AREA)
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  • Urology & Nephrology (AREA)
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  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Otolaryngology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
JP2010527904A 2007-10-05 2008-10-02 浮腫を治療または軽減するための新規な化合物およびその使用方法 Expired - Fee Related JP5547637B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97801007P 2007-10-05 2007-10-05
US60/978,010 2007-10-05
PCT/SE2008/000542 WO2009045145A1 (en) 2007-10-05 2008-10-02 Novel compounds for the treatment or alleviation of edema, and methods for their use

Related Child Applications (1)

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JP2014101486A Division JP5914567B2 (ja) 2007-10-05 2014-05-15 浮腫を治療または軽減するための新規な化合物およびその使用方法

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JP2010539974A JP2010539974A (ja) 2010-12-24
JP2010539974A5 JP2010539974A5 (https=) 2011-11-10
JP5547637B2 true JP5547637B2 (ja) 2014-07-16

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JP2010527904A Expired - Fee Related JP5547637B2 (ja) 2007-10-05 2008-10-02 浮腫を治療または軽減するための新規な化合物およびその使用方法
JP2014101486A Expired - Fee Related JP5914567B2 (ja) 2007-10-05 2014-05-15 浮腫を治療または軽減するための新規な化合物およびその使用方法

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Country Status (7)

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US (1) US8410068B2 (https=)
EP (2) EP2207555B1 (https=)
JP (2) JP5547637B2 (https=)
CA (1) CA2738070C (https=)
DK (1) DK2656850T3 (https=)
ES (1) ES2600919T3 (https=)
WO (1) WO2009045145A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2581480T3 (es) * 2007-05-04 2016-09-06 Index Pharmaceuticals Ab Compuestos inhibidores de crecimiento tumoral y métodos de uso de los mismos
CA2728276A1 (en) * 2008-06-18 2009-12-23 Index Pharmaceuticals Ab Combination therapies against cancer
TWI378933B (en) 2008-10-14 2012-12-11 Daiichi Sankyo Co Ltd Morpholinopurine derivatives
WO2010053435A2 (en) * 2008-11-04 2010-05-14 Index Pharmaceuticals Ab Compounds and methods for the treatment of inflammatory diseases of the cns
WO2012084991A1 (en) * 2010-12-21 2012-06-28 Index Pharmaceuticals Ab Biologically active oligonucleotides capable of modulating the immune system ii
US9157919B2 (en) * 2010-12-21 2015-10-13 Index Pharmaceuticals Ab Method for identifying biologically active oligonucleotides capable of modulating the immune system
MX383365B (es) * 2011-07-12 2025-03-13 Univ Vanderbilt Metodos para tratar inflamacion e hipertension con eliminadores de gama-cetoaldehidos.
GB201707501D0 (en) 2017-05-10 2017-06-21 Index Pharmaceuticals Ab New therapy 2

Family Cites Families (17)

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Publication number Priority date Publication date Assignee Title
US5610289A (en) * 1990-07-27 1997-03-11 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogues
US7517644B1 (en) * 1991-08-23 2009-04-14 Larry J. Smith Method and compositions for cellular reprogramming
EP2119784A3 (en) * 1991-08-23 2010-07-07 Board Of Regents Of The University Of Nebraska Method and compositions for cellular reprogramming
US5968826A (en) * 1998-10-05 1999-10-19 Isis Pharmaceuticals Inc. Antisense inhibition of integrin α4 expression
US6610836B1 (en) * 1999-01-29 2003-08-26 Genome Therapeutics Corporation Nucleic acid amino acid sequences relating to Klebsiella pneumoniae for diagnostics and therapeutics
US20110131679A2 (en) * 2000-04-19 2011-06-02 Thomas La Rosa Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
CA2419064A1 (en) * 2000-08-09 2002-02-14 Mount Sinai School Of Medicine Kruppel-like factor 6 (klf6), a tumor suppressor protein, and diagnostics, therapeutics, and screening based on this protein
US7630836B2 (en) * 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
CA2500521A1 (en) * 2002-10-02 2004-09-23 Nuvelo, Inc. Novel nucleic acids and polypeptides
CA2501095A1 (en) * 2002-10-15 2004-04-29 Novartis Ag Methods to predict edema as a side effect of drug treatment
JP2004166699A (ja) * 2002-11-06 2004-06-17 Takeda Chem Ind Ltd 抗利尿剤
US7250496B2 (en) * 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
WO2005033284A2 (en) * 2003-10-01 2005-04-14 The Regents Of The University Of California Compositions and methods for gene expression
US7374927B2 (en) * 2004-05-03 2008-05-20 Affymetrix, Inc. Methods of analysis of degraded nucleic acid samples
ATE439135T1 (de) 2005-07-01 2009-08-15 Index Pharmaceuticals Ab Modulierung der reaktion auf steroide
WO2007019563A2 (en) * 2005-08-09 2007-02-15 University Of Virginia Patent Foundation Methods and compositions for inhibition of vascular permeablility
ES2581480T3 (es) 2007-05-04 2016-09-06 Index Pharmaceuticals Ab Compuestos inhibidores de crecimiento tumoral y métodos de uso de los mismos

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Publication number Publication date
DK2656850T3 (en) 2016-11-28
CA2738070A1 (en) 2009-04-09
EP2656850A3 (en) 2014-02-12
JP2010539974A (ja) 2010-12-24
EP2207555A1 (en) 2010-07-21
EP2207555B1 (en) 2013-07-24
US20100240736A1 (en) 2010-09-23
US8410068B2 (en) 2013-04-02
EP2656850A2 (en) 2013-10-30
ES2600919T3 (es) 2017-02-13
CA2738070C (en) 2018-03-20
JP5914567B2 (ja) 2016-05-11
JP2014204722A (ja) 2014-10-30
WO2009045145A1 (en) 2009-04-09
EP2656850B1 (en) 2016-07-27
EP2207555A4 (en) 2010-11-24

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