DK2627328T3 - Kombinationer af serotoninreceptoragonister til behandling af bevægelseslidelser - Google Patents
Kombinationer af serotoninreceptoragonister til behandling af bevægelseslidelser Download PDFInfo
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- DK2627328T3 DK2627328T3 DK11776071.0T DK11776071T DK2627328T3 DK 2627328 T3 DK2627328 T3 DK 2627328T3 DK 11776071 T DK11776071 T DK 11776071T DK 2627328 T3 DK2627328 T3 DK 2627328T3
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- combination
- receptor
- agonist
- pharmaceutically acceptable
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Claims (15)
1. Farmaceutisk præparat eller kit-of-parts, som omfatter mindst én forbindelse, hvor forbindelsen er en 5-HT1D-, 5-HT1B- og 5-HT1 F-receptor- agonist eller et farmaceutisk acceptabelt derivat deraf, hvor forbindelsen er en triptan eller et farmaceutisk acceptabelt derivat deraf, og hvor præparatet eller kit-of-parts desuden omfatter en 5-HT1A-receptoragonist eller et farmaceutisk acceptabelt derivat deraf, til anvendelse til behandling, forebyggelse eller lindring af bevægelseslidelser.
2. Farmaceutisk præparat eller kit-of-parts til anvendelse ifølge krav 1, hvor forbindelsen har højere affinitet og/eller receptoraktiveringseffektivitet for 5-HT1 D-receptoren i sammenligning med 5-HT1B- og 5-HT1 F-receptorerne.
3. Farmaceutisk præparat eller kit-of-parts til anvendelse ifølge et hvilket som helst af de foregående krav, hvor forbindelsen er valgt fra gruppen bestående af zolmitriptan, sumatriptan, rizatriptan, naratriptan, almotriptan, frovatriptan og eletriptan eller farmaceutisk acceptable derivater deraf.
4. Farmaceutisk præparat eller kit-of-parts til anvendelse ifølge et hvilket som helst af de foregående krav, hvor 5-HT1A-receptoragonisten er valgt fra gruppen bestående af buspiron, alnespiron, binospiron, gepiron, ipsapiron, perospiron, tandospiron, befiradol, repinotan, piclozotan, osemozotan, flesinoxan, flibanserin og sarizotan eller farmaceutisk acceptable derivater deraf.
5. Farmaceutisk præparat eller kit-of-parts til anvendelse ifølge et hvilket som helst af de foregående krav, hvor forbindelsen er zolmitriptan eller et farmaceutisk acceptabelt derivat deraf, og 5-HT1 A-receptoragonisten er buspiron eller et farmaceutisk acceptabelt derivat deraf.
6. Farmaceutisk præparat eller kit-of-parts til anvendelse ifølge et hvilket som helst af de foregående krav, hvor forbindelsen administreres i doser på 0,05 - 200 mg/dag, såsom i doser på 0,5 - 60 mg/dag, såsom i doser på 0,5-10 mg/dag, og 5-HT1A-receptoragonisten administreres i doser på 0,05 - 500 mg/dag, såsom 0,5 - 100 mg/dag, såsom i doser på 0,5 - 30 mg/dag.
7. Farmaceutisk præparat eller kit-of-parts til anvendelse ifølge et hvilket som helst af de foregående krav, som desuden omfatter én eller flere yderligere aktive bestanddele.
8. Farmaceutisk præparat eller kit-of-parts til anvendelse ifølge krav 7, hvor den ene eller de flere yderligere aktive bestanddele er valgt fra gruppen bestående af: Midler, som øger dopaminkoncentrationen i den synaptiske kløft; midler, som anvendes til behandling af Parkinsons sygdom; dopamin; L-DOPA; dopaminreceptoragonister eller farmaceutisk acceptable derivater deraf; decarboxylaseinhibitorer; COMT-(catechol-0-methyltransferase)-inhibitorer; NMDA-(N-methyl-D-aspartat)-antagonister; MAO-B-inhibitorer; serotoninreceptormodulatorer; kappaopioidreceptoragonister, GABA-(gamma-aminosmørsyre)-modulatorer, modulatorer af neuronale kaliumkanaler og glutamatreceptormodulatorer.
9. Farmaceutisk præparat eller kit-of-parts til anvendelse ifølge et hvilket som helst af kravene 7 og 8, hvor forbindelsen er zolmitriptan eller et farmaceutisk acceptabelt derivat deraf, 5-HT1A-receptoragonisten er buspiron eller et farmaceutisk acceptabelt derivat deraf, og den ene eller de flere yderligere aktive bestanddele omfatter L-DOPA eller et farmaceutisk acceptabelt derivat deraf og/eller en decarboxylaseinhibitor og/eller en COMT-inhibitor.
10. Farmaceutisk præparat eller kit-of-parts til anvendelse ifølge krav 9, hvor decarbo-xylaseinhibitoren er carbidopa elle benserazid; og/eller hvor COMT-inhibitoren er tolca-pon eller entacapon.
11. Farmaceutisk præparat eller kit-of-parts til anvendelse ifølge et hvilket som helst af de foregående krav, hvor bevægelseslidelsen er valgt fra gruppen bestående af: En bevægelseslidelse associeret med ændrede eller svækkede synaptiske dopamin-niveauer; Parkinsons sygdom; bevægelseslidelser associeret med Parkinsons sygdom, herunder bradykinesi, akinesi og dyskinesi; L-DOPA-induceret dyskinesi; tardiv dyski-nesi og akatisi.
12. Farmaceutisk præparat eller kit-of-parts til anvendelse ifølge et hvilket som helst af de foregående krav, hvor bevægelseslidelsen er valgt fra gruppen bestående af ataksi, dystoni, essentiel tremor, Huntingtons sygdom, myokloni, Rett-syndrom, Tourettes syndrom, Wilsons sygdom, chorea, Machado-Joseph-sygdom, rastløse ben-syndrom, spasmodisk torticollis, geniospasme og bevægelseslidelser forårsaget af idiopatisk sygdom, genetiske dysfunktioner eller infektioner eller dysfunktion af de basale ganglier.
13. Farmaceutisk præparat eller kit-of-parts til anvendelse ifølge et hvilket som helst af de foregående krav, hvor bevægelseslidelsen er forårsaget af eller associeret med lægemiddelterapi, herunder neuroleptiske lægemidler, antipsykotiske midler, antidepres-sive midler og antiemetiske lægemidler; eller forårsaget af eller associeret med afvænning fra lægemidler, herunder opioider, barbiturater, kokain, benzodiazepiner, alkohol og amfetamin.
14. Farmaceutisk præparat eller kit-of-parts til anvendelse ifølge et hvilket som helst af kravene 7 til 10, hvor den ene eller de flere aktive bestanddele skal administreres samtidigt, sekventielt eller separat fra det farmaceutiske præparat eller kit-of-parts.
15. Anvendelse af et farmaceutisk præparat eller kit-of-parts, som omfatter mindst én forbindelse, hvor forbindelsen er en 5-HT1D-, 5-HT1B- og 5-HT1 F-receptor- agonist eller et farmaceutisk acceptabelt derivat deraf, hvor forbindelsen er en triptan eller et farmaceutisk acceptabelt derivat deraf, og hvor præparatet eller kit-of-parts desuden omfatter en 5-HT1A-receptoragonist eller et farmaceutisk acceptabelt derivat deraf, til fremstilling af et lægemiddel til behandling, forebyggelse eller lindring af bevægelseslidelser.
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WO2012163365A1 (en) * | 2011-06-01 | 2012-12-06 | Concit Pharma Aps | Combinations of serotonin receptor agonists for treatment of movement disorders |
JP6216768B2 (ja) | 2012-04-18 | 2017-10-18 | コンテラ ファーマ アンパルトセルスカブContera Pharma Aps | 運動障害の管理の改善に適した経口投与可能な医薬製剤 |
CA2876203A1 (en) * | 2012-06-11 | 2013-12-19 | Psychogenics, Inc. | Use of eltoprazine in the treatment of motor and movement disorders associated with the treatment of parkinson's disease |
ES2686529T3 (es) * | 2014-06-26 | 2018-10-18 | Contera Pharma Aps | 6-hidroxibuspirona para su uso en el tratamiento de trastornos del movimiento |
RU2702101C2 (ru) * | 2014-07-09 | 2019-10-04 | Пьер Фабр Медикамент | Способ лечения двигательных расстройств бефирадолом |
WO2016210431A1 (en) * | 2015-06-26 | 2016-12-29 | Wright State University | Method of treating sepsis-induced myopathy |
US11013830B2 (en) * | 2015-11-20 | 2021-05-25 | Institut Pasteur | 5-hydroxytryptamine 1B receptor-stimulating agent for enhancing in vivo engraftment potential |
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US20230057844A1 (en) * | 2019-12-20 | 2023-02-23 | The Jackson Laboratory | Molecular targets for addiction |
CN112931397B (zh) * | 2021-01-25 | 2024-02-27 | 江南大学 | 一种帕金森病动物模型的构建方法 |
CN114712365B (zh) * | 2022-06-07 | 2022-08-23 | 山东绿叶制药有限公司 | Trk抑制剂在制备治疗迟发性运动障碍药物中的应用 |
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