DK2598533T3 - Fusionsproteiner af naturlige humane proteinfragmenter til på en ordnet måde at skabe multimeriserede immunoglobulin-FC-sammensætninger - Google Patents
Fusionsproteiner af naturlige humane proteinfragmenter til på en ordnet måde at skabe multimeriserede immunoglobulin-FC-sammensætninger Download PDFInfo
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- DK2598533T3 DK2598533T3 DK11813204.2T DK11813204T DK2598533T3 DK 2598533 T3 DK2598533 T3 DK 2598533T3 DK 11813204 T DK11813204 T DK 11813204T DK 2598533 T3 DK2598533 T3 DK 2598533T3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (10)
1. Polypeptid, som omfatter SEQ ID NO: 4.
2. Polypeptid ifølge krav 1, hvor leader-sekvensen er spaltet.
3. Sammensætning omfattende multimerer af dimere af polypeptiderne ifølge krav 1 eller 2, hvor multimererne foreligger med en procentdel på mindst ca. 45 %, eller mindst ca. 55 %, eller mindst ca. 65 %, eller mindst ca. 70 %, eller mindst ca. 73 % af den samlede sammensætning.
4. Biomimetisk forbindelse omfattende mindst to dimere af polypeptider ifølge krav 1 eller krav 2.
5. Biomimetisk forbindelse ifølge krav 4 til anvendelse ved en fremgangsmåde til modulering af et immunrespons eller behandling af en inflammatorisk sygdom hos et individ, hvor fremgangsmåden omfatter at indgive en virksom mængde af den biomimetiske forbindelse til individet.
6. Biomimetisk forbindelse til anvendelse ifølge krav 5, hvor den inflammatoriske sygdom er en sygdom udvalgt blandt arthritis, multipel sklerose, type I diabetes, autoimmun thyroiditis, idiopatisktrombocytopenisk purpura, kronisk inflammatorisk polyneuropati, sklerodermi, autoimmun uveitis, systemisk lupus erythematosus, myasthenia gravis og atopisk dermatitis eller en sygdom associeret med transplantation af et organ fra en donor til en modtager; eller en infektionssygdom, en bakteriesygdom eller en virusinfektion.
7. Fremgangsmåde til blokering af ikke-specifik binding af antistoffer i et in vitro- eller ex v/vo-assay omfattende at inkubere targetvæv eller targetceller med en sammensætning omfattende en virksom mængde af den biomimetiske forbindelse ifølge krav 4.
8. Fremgangsmåde til fremstilling til fremstilling af en biomimetisk forbindelse omfattende at eksprimere SEQ ID NO: 4 i en vært.
9. Fremgangsmåde ifølge krav 8, endvidere omfattende: (a) at klone et DNA, der koder polypeptidet med SEQ ID NO: 4, til en ekspressionsvektor; (b) at transficere ekspressionsvektoren til en bakteriel vært; (c) at isolere plasmid-DNA'et, der indeholder klonet DNA, fra bakteriekulturen; (d) at linearisere plasmid-DNA'et indeholdende klonet DNA; (e) at transficere det lineariserede DNA til pattedyrceller; (f) at udvide de positivt transficerede celler for at opnå en pool af stabilt trans-ficerede celler; (g) at høste polypeptidet fra mediet; og (h) at oprense polypeptidet, hvor polypeptidet ikke indeholder nogen fremmed-sekvenser.
10. Fremgangsmåde ifølge krav 9, hvor leader-sekvensen er spaltet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36846510P | 2010-07-28 | 2010-07-28 | |
PCT/US2011/045768 WO2012016073A2 (en) | 2010-07-28 | 2011-07-28 | Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2598533T3 true DK2598533T3 (da) | 2019-04-23 |
Family
ID=45530725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK11813204.2T DK2598533T3 (da) | 2010-07-28 | 2011-07-28 | Fusionsproteiner af naturlige humane proteinfragmenter til på en ordnet måde at skabe multimeriserede immunoglobulin-FC-sammensætninger |
Country Status (21)
Country | Link |
---|---|
US (3) | US20130156765A1 (da) |
EP (2) | EP2598533B1 (da) |
JP (2) | JP5826270B2 (da) |
KR (3) | KR102148265B1 (da) |
CN (2) | CN103154036B (da) |
AR (1) | AR082404A1 (da) |
AU (1) | AU2011282579B2 (da) |
BR (1) | BR112013002074B1 (da) |
CA (2) | CA2804512C (da) |
DK (1) | DK2598533T3 (da) |
ES (1) | ES2719623T3 (da) |
HR (1) | HRP20190652T1 (da) |
HU (1) | HUE044869T2 (da) |
IL (3) | IL224427A (da) |
MX (3) | MX368531B (da) |
PL (1) | PL2598533T3 (da) |
PT (1) | PT2598533T (da) |
SI (1) | SI2598533T1 (da) |
TR (1) | TR201906652T4 (da) |
TW (2) | TWI542597B (da) |
WO (1) | WO2012016073A2 (da) |
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