DK2517738T3 - Et kollagen/hydroxyapatit-komposit-scaffold - Google Patents

Et kollagen/hydroxyapatit-komposit-scaffold Download PDF

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Publication number
DK2517738T3
DK2517738T3 DK12178368.2T DK12178368T DK2517738T3 DK 2517738 T3 DK2517738 T3 DK 2517738T3 DK 12178368 T DK12178368 T DK 12178368T DK 2517738 T3 DK2517738 T3 DK 2517738T3
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DK
Denmark
Prior art keywords
collagen
scaffold
hydroxyapatite
composite scaffold
acetic acid
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DK12178368.2T
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English (en)
Inventor
Fergal O'brien
John Gleeson
Niamh Plunkett
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Royal College Surgeons Ireland
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Publication of DK2517738T3 publication Critical patent/DK2517738T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Dental Preparations (AREA)

Claims (14)

1. Kollagen/hydroxyapatit (HA) -komposit-scaffold omfattende en homogen distribution af hydroxyapatit i en porøs kollagenmatrix, hvor forholdet mellem HA og kollagen er mindst 1:10 (vægt/vægt), hvor komposit-scaffoldet har en porøsitet på mindst 98 % (volumen/volumen) og trykstivhed på mindst 0,4 kPa, og hvor komposit-scaffoldet omfatter celler.
2. Kollagen/hydroxyapatit (HA) -komposit-scaffold ifølge krav 1, der har et forhold mellem HA og kollagen på mindst 10:10 eller mindst 10:20 (vægt/vægt).
3. Kollagen/hydroxyapatit (HA) -komposit-scaffold ifølge et hvilket som helst af kravene 1 eller 2, der har en porøsitet på mindst 99 % (volumen/volumen).
4. Kollagen/hydroxyapatit (HA) -komposit-scaffold ifølge et hvilket som helst af kravene 1 til 3, der er dehydrotermisk og EDAC-tværbundet, der har en trykstivhed på mindst 1,0 kPa, 2,0 kPa, eller 3 kPa.
5. Kollagen/hydroxyapatit (HA) -komposit-scaffold ifølge et hvilket som helst af kravene 1 til 4, hvor forholdet mellem HA og kollagen i komposit-scaffoldet er fra 1:10 (vægt/vægt) til 50:10 (vægt/vægt), eller fra 5:10 (vægt/vægt) til 30:10 (vægt/vægt).
7. Kollagen/hydroxyapatit (HA) -komposit-scaffold ifølge et hvilket som helst af kravene 1 til 6, hvor komposit-scaffoldet er kendetegnet ved at have strømnings-ledningsevne undertryk gennem scaffoldet på mindst 1 x 10'10 m4/l\ls.
8. Kollagen/hydroxyapatit (HA) -komposit-scaffold ifølge et hvilket som helst af kravene 1 til 7, hvor scaffoldet er fremstillet i formen af en plade.
9. Kollagen/hydroxyapatit (HA) -komposit-scaffold ifølge et hvilket som helst af kravene 1 til 8, hvor komposit-scaffoldet er podet med mindst 1 x 106 celler per 500 mm3 volumen af scaffold.
10. Kollagen/hydroxyapatit (HA) -komposit-scaffold ifølge et hvilket som helst af kravene 1 til 9, der er tværbundet.
11. Osteokonduktivt knogleimplantat omfattende et kollagen/hydroxyapatit-komposit-scaffold ifølge et hvilket som helst af kravene 1 til 10.
12. Vævsteknologisk implantat omfattende et kollagen/hydroxyapatit-komposit-scaffold ifølge et hvilket som helst af kravene 1 til 10.
13. Maxillofacial knoglevævs-substitut omfattende et kollagen/hydroxyapatit-komposit-scaffold ifølge et hvilket som helst af kravene 1 til 10.
14. Dental knoglevævs-substitut eller brusk-defekt-reparations-implantat eller osteochondralt-defekt-reparationsimplantat, omfattende et kollagen/hydroxyapatit-komposit-scaffold ifølge et hvilket som helst af kravene 1 til 10.
15. Kollagen/hydroxyapatit-komposit-scaffold ifølge et hvilket som helst af kravene 1 til 10, hvor cellerne er osteoblaster.
DK12178368.2T 2007-02-09 2008-02-11 Et kollagen/hydroxyapatit-komposit-scaffold DK2517738T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20070394001 EP1964583A1 (en) 2007-02-09 2007-02-09 Process for producing a collagen/hydroxyapatite composite scaffold
EP20080710143 EP2117617B1 (en) 2007-02-09 2008-02-11 A collagen/hydroxyapatite composite scaffold, and process for the production thereof

Publications (1)

Publication Number Publication Date
DK2517738T3 true DK2517738T3 (da) 2017-12-04

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Family Applications (2)

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DK08710143T DK2117617T3 (da) 2007-02-09 2008-02-11 Kollagen/hydroxyapatit-komposit-scaffold, og fremgangsmåde til fremstilling deraf
DK12178368.2T DK2517738T3 (da) 2007-02-09 2008-02-11 Et kollagen/hydroxyapatit-komposit-scaffold

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Country Status (13)

Country Link
US (2) US8435552B2 (da)
EP (3) EP1964583A1 (da)
JP (2) JP5527760B2 (da)
AU (1) AU2008212526B2 (da)
CA (1) CA2677992C (da)
DK (2) DK2117617T3 (da)
ES (2) ES2435192T3 (da)
IL (1) IL200295A (da)
NO (1) NO2517738T3 (da)
NZ (1) NZ579466A (da)
PL (2) PL2117617T3 (da)
PT (2) PT2517738T (da)
WO (1) WO2008096334A2 (da)

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NZ579466A (en) 2012-08-31
JP5881669B2 (ja) 2016-03-09
PL2117617T3 (pl) 2014-01-31
EP2517738B1 (en) 2017-08-23
CA2677992C (en) 2017-03-21
AU2008212526B2 (en) 2013-06-06
EP1964583A1 (en) 2008-09-03
CA2677992A1 (en) 2008-08-14
EP2117617B1 (en) 2013-08-14
DK2117617T3 (da) 2013-11-18
EP2117617A2 (en) 2009-11-18
JP5527760B2 (ja) 2014-06-25
JP2010517659A (ja) 2010-05-27
US9138483B2 (en) 2015-09-22
EP2517738A1 (en) 2012-10-31
AU2008212526A1 (en) 2008-08-14
WO2008096334A2 (en) 2008-08-14
PT2117617E (pt) 2013-11-20
NO2517738T3 (da) 2018-01-20
WO2008096334A3 (en) 2008-10-30
PT2517738T (pt) 2017-11-28
PL2517738T3 (pl) 2018-03-30
ES2649091T3 (es) 2018-01-10
JP2014076387A (ja) 2014-05-01
US20100158976A1 (en) 2010-06-24
IL200295A (en) 2015-06-30
WO2008096334B1 (en) 2008-12-18
ES2435192T3 (es) 2013-12-16
US8435552B2 (en) 2013-05-07
IL200295A0 (en) 2010-04-29
US20130177648A1 (en) 2013-07-11

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