DK2488170T3 - Sammensætninger, der omfatter tramadol og celecoxib, til behandling af smerter - Google Patents
Sammensætninger, der omfatter tramadol og celecoxib, til behandling af smerter Download PDFInfo
- Publication number
- DK2488170T3 DK2488170T3 DK10765762.9T DK10765762T DK2488170T3 DK 2488170 T3 DK2488170 T3 DK 2488170T3 DK 10765762 T DK10765762 T DK 10765762T DK 2488170 T3 DK2488170 T3 DK 2488170T3
- Authority
- DK
- Denmark
- Prior art keywords
- pain
- celecoxib
- tramadol
- pharmaceutical composition
- rac
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (4)
1. Farmaceutisk sammensætning, omfattende en kombination af (rac)-tramadol-HCI og celecoxib eller et farmaceutisk acceptabelt salt eller hydrat deraf, hvor det molekylære forhold mellem (rac)-tramadol-HCI og celecoxib er et molforhold fra 1:1 til 1:5 eller fra 1:1 til 5:1.
2. Farmaceutisk sammensætning ifølge krav 1, hvor celecoxib foreligger i neutral form.
3. Farmaceutisk sammensætning ifølge krav 1, hvor det molekylære forhold mellem (rac)-tramadol-FICI og celecoxib er et molforhold på 1:1.
4. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 1 eller 3 til anvendelse som et analgetikum eller til anvendelse i behandling af smerte, fortrinsvis akut smerte, kronisk smerte, neuropatisk smerte, nociceptiv smerte, mild og svær til moderat smerte, hyperalgesi, smerte relateret til central sensibilisering, allodyni eller cancersmerte, herunder diabetisk neuropati eller diabetisk perifer neuropati og osteoarthritis, fibromyalgi, rheumatoid arthritis, ankyloserende spondylitis, frossen skulder eller iskias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09384004A EP2311446A1 (en) | 2009-10-16 | 2009-10-16 | Compositions comprising Tramadol and Celecoxib in the treatment of pain |
PCT/EP2010/006317 WO2011045075A1 (en) | 2009-10-16 | 2010-10-15 | Compositions comprising tramadol and celecoxib in the treatment of pain |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2488170T3 true DK2488170T3 (da) | 2014-03-03 |
Family
ID=41566149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10765762.9T DK2488170T3 (da) | 2009-10-16 | 2010-10-15 | Sammensætninger, der omfatter tramadol og celecoxib, til behandling af smerter |
Country Status (34)
Country | Link |
---|---|
US (3) | US8569271B2 (da) |
EP (3) | EP2311446A1 (da) |
JP (2) | JP5579858B2 (da) |
KR (1) | KR101688996B1 (da) |
CN (2) | CN107050006A (da) |
AR (1) | AR078653A1 (da) |
AU (1) | AU2010306114B2 (da) |
BR (1) | BR112012005044B8 (da) |
CA (1) | CA2771651C (da) |
CO (1) | CO6511249A2 (da) |
CY (1) | CY1114960T1 (da) |
DK (1) | DK2488170T3 (da) |
EC (1) | ECSP12011735A (da) |
ES (1) | ES2450615T3 (da) |
HK (1) | HK1173379A1 (da) |
HR (1) | HRP20140157T1 (da) |
IL (1) | IL218096A (da) |
IN (1) | IN2012DN01434A (da) |
MA (1) | MA33743B1 (da) |
MX (1) | MX2012003051A (da) |
MY (1) | MY156275A (da) |
NZ (1) | NZ598361A (da) |
PL (1) | PL2488170T3 (da) |
PT (1) | PT2488170E (da) |
RS (1) | RS53202B (da) |
RU (2) | RU2012120087A (da) |
SG (1) | SG178833A1 (da) |
SI (1) | SI2488170T1 (da) |
SM (1) | SMT201400035B (da) |
TN (1) | TN2012000059A1 (da) |
TW (1) | TWI466668B (da) |
UA (1) | UA108213C2 (da) |
WO (1) | WO2011045075A1 (da) |
ZA (1) | ZA201202151B (da) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2177215A1 (en) | 2008-10-17 | 2010-04-21 | Laboratorios Del. Dr. Esteve, S.A. | Co-crystals of tramadol and NSAIDs |
US8746719B2 (en) | 2010-08-03 | 2014-06-10 | Polaris Industries Inc. | Side-by-side vehicle |
KR102165246B1 (ko) * | 2011-04-05 | 2020-10-13 | 옵토솔브 리서치 앤드 디벨롭먼트 리미티드 | 안과 치료제 |
US20130203783A1 (en) * | 2012-02-06 | 2013-08-08 | William L. Pridgen | Valaciclovir and celecoxib combination therapy for functional somatic syndromes |
WO2016116942A1 (en) | 2015-01-20 | 2016-07-28 | Anlon Chemical Research Organization | Novel pharmaceutical compounds comprising ticagrelor with salts of aspirin |
CA2987272C (en) * | 2015-05-28 | 2019-08-20 | Dr. Reddy's Laboratories Ltd. | Oral composition of celecoxib for treatment of pain |
KR101710792B1 (ko) * | 2015-07-14 | 2017-02-28 | 주식회사 유영제약 | 세레콕시브 및 트라마돌을 함유하는 약제학적 조성물 |
MX2016006464A (es) * | 2016-05-18 | 2017-11-17 | Laboratorios Liomont S A De C V | Composicion farmaceutica de una combinacion de clorhidrato de tramadol-etoricoxib para el tratamiento del dolor. |
RU2745196C2 (ru) * | 2016-05-27 | 2021-03-22 | Др. Редди'С Лабораторис Лтд. | Пероральная композиция целекоксиба для лечения боли |
WO2018186650A2 (ko) * | 2017-04-03 | 2018-10-11 | 주식회사 킴스헬스케어 | 트라마돌과 셀레콕시브를 포함한 경구투여용 이중 복합정제 |
US20200323780A1 (en) | 2017-04-03 | 2020-10-15 | Kims Healthcare Co., Ltd. | Bilayer combination tablet for oral administration containing tramadol and celecoxib |
KR102631399B1 (ko) | 2018-03-30 | 2024-02-01 | 씨지인바이츠 주식회사 | 폴마콕시브 및 프레가발린을 포함하는 통증 치료용 약제학적 조성물 |
MX2021013123A (es) * | 2019-05-14 | 2021-11-18 | Esteve Pharmaceuticals Sa | Uso de co-cristales de tramadol y celecoxib para el tratamiento del dolor mientras se reduce la responsabilidad por abuso de tramadol. |
CN112007024A (zh) * | 2019-05-28 | 2020-12-01 | 江苏恒瑞医药股份有限公司 | 艾瑞昔布与曲马多联合在制备治疗疼痛的药物中的用途 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5516803A (en) | 1991-10-30 | 1996-05-14 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
AU661723B2 (en) | 1991-10-30 | 1995-08-03 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
RS49982B (sr) * | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
JP2002538176A (ja) * | 1999-03-01 | 2002-11-12 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | トラマドール物質および選択的cox−2阻害薬を含んで成る組成物 |
DE19927688A1 (de) | 1999-06-17 | 2000-12-21 | Gruenenthal Gmbh | Mehrschichttablette zur Verabreichung einer fixen Kombination von Tramadol und Diclofenac |
US7790905B2 (en) * | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
WO2003070251A1 (en) * | 2002-02-19 | 2003-08-28 | Adcock Ingram Limited | Pharmaceutical combinations of cox-2 inhibitors and opiates |
US20080031950A1 (en) * | 2007-04-27 | 2008-02-07 | Nectid Inc. | Novel anelgesic combination |
BR112012005011B8 (pt) * | 2009-10-16 | 2021-05-25 | Esteve Pharmaceuticals Sa | cocristal de tramadol e celecoxib, processo para sua produção e composição farmacêutica |
EP2392319A1 (en) * | 2010-06-04 | 2011-12-07 | Laboratorios Del. Dr. Esteve, S.A. | Pharmaceutical compositions of co-crystals of tramadol and coxibs |
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2009
- 2009-10-16 EP EP09384004A patent/EP2311446A1/en not_active Withdrawn
-
2010
- 2010-10-14 TW TW99134996A patent/TWI466668B/zh active
- 2010-10-15 SI SI201030545T patent/SI2488170T1/sl unknown
- 2010-10-15 UA UAA201205897A patent/UA108213C2/uk unknown
- 2010-10-15 AR ARP100103776A patent/AR078653A1/es not_active Application Discontinuation
- 2010-10-15 IN IN1434DEN2012 patent/IN2012DN01434A/en unknown
- 2010-10-15 RU RU2012120087/15A patent/RU2012120087A/ru unknown
- 2010-10-15 AU AU2010306114A patent/AU2010306114B2/en active Active
- 2010-10-15 SG SG2012010898A patent/SG178833A1/en unknown
- 2010-10-15 CN CN201611195215.9A patent/CN107050006A/zh active Pending
- 2010-10-15 KR KR1020127009600A patent/KR101688996B1/ko active IP Right Review Request
- 2010-10-15 WO PCT/EP2010/006317 patent/WO2011045075A1/en active Application Filing
- 2010-10-15 JP JP2012533530A patent/JP5579858B2/ja active Active
- 2010-10-15 PT PT107657629T patent/PT2488170E/pt unknown
- 2010-10-15 EP EP10765762.9A patent/EP2488170B1/en active Active
- 2010-10-15 ES ES10765762.9T patent/ES2450615T3/es active Active
- 2010-10-15 US US13/394,995 patent/US8569271B2/en active Active
- 2010-10-15 PL PL10765762T patent/PL2488170T3/pl unknown
- 2010-10-15 CA CA2771651A patent/CA2771651C/en active Active
- 2010-10-15 NZ NZ598361A patent/NZ598361A/en unknown
- 2010-10-15 RS RS20140100A patent/RS53202B/en unknown
- 2010-10-15 RU RU2016125895A patent/RU2707752C2/ru active
- 2010-10-15 MX MX2012003051A patent/MX2012003051A/es active IP Right Grant
- 2010-10-15 BR BR112012005044A patent/BR112012005044B8/pt active IP Right Grant
- 2010-10-15 CN CN2010800463605A patent/CN102573824A/zh active Pending
- 2010-10-15 EP EP13005822.5A patent/EP2737898A1/en not_active Withdrawn
- 2010-10-15 MY MYPI2012000614A patent/MY156275A/en unknown
- 2010-10-15 DK DK10765762.9T patent/DK2488170T3/da active
-
2012
- 2012-02-10 TN TNP2012000059A patent/TN2012000059A1/en unknown
- 2012-02-14 IL IL218096A patent/IL218096A/en active IP Right Grant
- 2012-03-16 CO CO12046133A patent/CO6511249A2/es active IP Right Grant
- 2012-03-19 EC ECSP12011735 patent/ECSP12011735A/es unknown
- 2012-03-23 ZA ZA2012/02151A patent/ZA201202151B/en unknown
- 2012-05-11 MA MA34860A patent/MA33743B1/fr unknown
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2013
- 2013-01-17 HK HK13100719.5A patent/HK1173379A1/xx unknown
- 2013-09-25 US US14/036,828 patent/US20140024622A1/en not_active Abandoned
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2014
- 2014-02-19 HR HRP20140157AT patent/HRP20140157T1/hr unknown
- 2014-03-10 CY CY20141100195T patent/CY1114960T1/el unknown
- 2014-03-20 SM SM201400035T patent/SMT201400035B/xx unknown
- 2014-07-09 JP JP2014141720A patent/JP2014221797A/ja not_active Withdrawn
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2015
- 2015-02-04 US US14/613,475 patent/US20150150889A1/en not_active Abandoned
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