DK2451284T3 - Nye guldbaserede nanokrystaller til medicinske behandlinger og elektrokemiske processer til fremstilling deraf - Google Patents

Nye guldbaserede nanokrystaller til medicinske behandlinger og elektrokemiske processer til fremstilling deraf Download PDF

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DK2451284T3
DK2451284T3 DK10797874.4T DK10797874T DK2451284T3 DK 2451284 T3 DK2451284 T3 DK 2451284T3 DK 10797874 T DK10797874 T DK 10797874T DK 2451284 T3 DK2451284 T3 DK 2451284T3
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gold
nanocrystals
electrode
liquid
figures
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DK10797874.4T
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Mark Mortenson
D Kyle Pierce
David Bryce
Adam Dorfman
Reed Wilcox
Anthony Lockett
Mikhail Merzliakov
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Clene Nanomedicine Inc
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Claims (10)

  1. NYE GULDBASEREDE NANOKRYSTALLER TIL MEDICINSKE BEHANDLINGER OG ELEKTROKEMISKE PROCESSER TIL FREMSTILLING DERAF
    1. Farmaceutisk acceptabel suspensionssammensætning omfattende: a. ) vand; b. ) en forarbejdningsforstærker; og c. ) guldnanokrystaller suspenderet i vandet, så der dannes en suspension, hvori guldnanokrystallerne: 1. ) har overflader, der: (1) i det væsentlige er fri for organiske eller andre urenheder eller film; eller (2) ikke har kemiske bestanddele adhæreret eller hæftet på sig, der danner et lag, en overflade eller en film, som dækker mindst 50 % af krystallen og fortrinsvis mindst 25 % af krystallen; ii. ) har en modalpartikelstørrelse på mindre end 100 nm; iii. ) er til stede i suspensionen i en koncentration på 2-200 ppm; og iv. ) indeholder mindst ét rumligt udvidet lavt indekskrystalplan udvalgt fra gruppen bestående af {111}, {110} og {100} og deres ækvivalenter; og hvori suspensionen har en pH på mellem 4,0 til 9,5 og et zetapotentiale på mindst -20 mV.
  2. 2. Sammensætning ifølge krav 1, hvori suspensionen har en pH på mellem 5,0 til 9,5.
  3. 3. Sammensætning ifølge krav 1 eller 2, hvori suspensionen har et zetapotentiale på mindst -40 mV.
  4. 4. Sammensætning ifølge et hvilket som helst af kravene 1 til 3, hvori nanokrystallerne har en modalpartikelstørrelse på mindre end 5 0 nm.
  5. 5. Sammensætning ifølge et hvilket som helst af kravene 1 til 4, hvori forarbejdningsforstærkeren omfatter natriumbicarbonat.
  6. 6. Sammensætning ifølge et hvilket som helst af kravene 1 til 5, hvori nanokrystallerne er formet, hvilke former omfatter pentagonale bipyramider og tetraedre i et område på 15 til 50 %.
  7. 7. Sammensætning ifølge et hvilket som helst af kravene 1 til 6 til anvendelse i behandlingen af en patient med en tilstand, der er modtagelig over for guldterapi.
  8. 8. Sammensætning ifølge krav 7, hvori tilstanden er udvalgt fra gruppen bestående af reumatoid artritis, osteoartritis, systemisk lupus erythematosus, ulcerativ colitis, Crohns sygdom, multipel sklerose, psoriasis, eksem, uveitis, diabetes mellitus, glomerulonefritis, aterosklerotisk karsygdom og infarkt, astma, kronisk obstruktiv lungesygdom, HIV, HBV, HCV, tuberkulose, malaria, orm og cancer(e).
  9. 9. Sammensætning til anvendelse ifølge krav 7, hvori tilstanden er artritis eller multipel sklerose.
  10. 10. Sammensætning ifølge et hvilket som helst af kravene 1 til 6 til oral administration.
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