SG10201908339RA - Novel gold-based nanocrystals for medical treatments and electrochemical manufacturing processes therefor - Google Patents

Novel gold-based nanocrystals for medical treatments and electrochemical manufacturing processes therefor

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Publication number
SG10201908339RA
SG10201908339RA SG10201908339RA SG10201908339RA SG 10201908339R A SG10201908339R A SG 10201908339RA SG 10201908339R A SG10201908339R A SG 10201908339RA SG 10201908339R A SG10201908339R A SG 10201908339RA
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Singapore
Prior art keywords
gold
conditions
nanocrystals
novel
electrochemical manufacturing
Prior art date
Application number
Inventor
Mark Mortenson
D Pierce
David Bryce
Adam Dorfman
Reed Wilcox
Anthony Lockett
Mikhail Merzliakov
Original Assignee
Clene Nanomedicine Inc
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Publication date
Application filed by Clene Nanomedicine Inc filed Critical Clene Nanomedicine Inc
Publication of SG10201908339RA publication Critical patent/SG10201908339RA/en

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    • A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
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Abstract

NOVEL GOLD-BASED NANOCRYSTALS FOR MEDICAL TREATMENTS AND ELECTROCHEMICAL MANUFACTURING PROCESSES THEREFOR The present invention relates to novel gold nanocrystals and nanocrystal shape distributions that have surfaces that are substantially free from organic impurities or films. Specifically, the surfaces are "clean" relative to the surfaces of gold nanoparticles made using chemical reduction processes that require organic reductants and/or surfactants to grow gold nanoparticles from gold ions in solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the gold-based nanocrystals. The invention further includes pharmaceutical compositions thereof and the use of the gold nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which gold therapy is already known and more generally for conditions resulting from pathological cellular activation, such as inflammatory (including chronic inflammatory) conditions, autoimmune conditions, hypersensitivity reactions and/or cancerous diseases or conditions In one embodiment, the condition is mediated by MIF (macrophage migration inhibiting factor). Figure la
SG10201908339R 2009-07-08 2010-07-08 Novel gold-based nanocrystals for medical treatments and electrochemical manufacturing processes therefor SG10201908339RA (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US22394409P 2009-07-08 2009-07-08
US22615309P 2009-07-16 2009-07-16
US22825009P 2009-07-24 2009-07-24
US23557409P 2009-08-20 2009-08-20
US24980409P 2009-10-08 2009-10-08
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Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2178796T (en) * 2007-07-11 2021-03-29 Clene Nanomedicine Inc Continuous methods for treating liquids and manufacturing certain constituents (e.g., nanoparticles) in liquids, apparatuses and nanoparticles and nanoparticle/liquid solution(s) resulting therefrom
US9387452B2 (en) 2009-01-14 2016-07-12 Gr Intellectual Reserve, Llc. Continuous methods for treating liquids and manufacturing certain constituents (e.g., nanoparticles) in liquids, apparatuses and nanoparticles and nanoparticle/liquid solution(s) resulting therefrom
DK2387478T3 (en) 2009-01-15 2018-10-29 Clene Nanomedicine Inc CONTINUOUS PROCESS AND APPARATUS FOR THE CREATION OF GOLD-BASED NANOPARTICLES
SG10201403497QA (en) * 2009-07-08 2014-10-30 Gr Intellectual Reserve Llc Novel gold-based nanocrystals for medical treatments and electrochemical manufacturing processes therefor
US9346832B2 (en) * 2010-06-17 2016-05-24 University Of Kwazulu-Natal Gold complexes for use in the treatment of cancer
US20130323166A1 (en) * 2010-09-10 2013-12-05 William Beaumont Hospital Radiation Therapy for Treating Alzheimer's Disease
KR101955735B1 (en) * 2011-03-30 2019-03-07 클레네 나노메디슨, 인크. Novel gold-platinum based bi-metallic nanocrystal suspensions, electrochemical manufacturing processes therefor and uses for the same
EP2735389A1 (en) * 2012-11-23 2014-05-28 Universität Duisburg-Essen Process for the preparation of pure, in particular carbon-free nanoparticles
PT2994146T (en) * 2013-05-08 2021-03-31 Clene Nanomedicine Inc Methods and treatment for certain demyelination and dysmyelination-based disorders and/or promoting remyelination
GB2529185B (en) 2014-08-12 2021-03-03 Kathrein Se Method and system for relaying telecommunications signals wtih efficient joint capacity
EP3212074B1 (en) 2014-10-30 2020-04-22 Kardium Inc. Systems for ablating tissue
KR102328995B1 (en) * 2014-11-26 2021-11-23 나노리소스 주식회사 Separation method of Detonation Nano Diamond
CN104867267B (en) * 2015-03-15 2017-10-27 李洪 Save disaster reduction device
CN104759753B (en) * 2015-03-30 2016-08-31 江苏大学 The co-ordination of multisystem automatization improves the method for induced with laser cavitation reinforcement
EP3291846A4 (en) * 2015-05-07 2018-12-05 The Regents of The University of Michigan Process for electro-hydrodynamically enhanced destruction of chemical air contaminants and airborne inactivation of biological agents
JP6590309B2 (en) * 2015-07-31 2019-10-16 学校法人関東学院 Plastic substrate with conductive layer and manufacturing method thereof
US11311940B2 (en) 2016-05-25 2022-04-26 University Of Florida Research Foundation, Inc. Light-driven synthesis of plasmonic nanoparticles and nanomaterials
EP3449945B1 (en) * 2016-08-05 2022-02-09 Shenzhen Profound-View Pharma Tech Co., Ltd. Substance containing gold cluster and preparation method and use thereof
US10195683B2 (en) * 2016-11-14 2019-02-05 Matthew Fagan Metal analyzing plasma CNC cutting machine and associated methods
US10300551B2 (en) * 2016-11-14 2019-05-28 Matthew Fagan Metal analyzing plasma CNC cutting machine and associated methods
US10029019B1 (en) 2017-01-20 2018-07-24 Xueyun Gao Method for mitigating osteoporosis using metallic gold cluster molecules
CN108569483A (en) * 2017-03-13 2018-09-25 富泰华工业（深圳）有限公司 Intelligence takes liquid system
CN107217279B (en) * 2017-05-31 2018-10-02 东北大学 A kind of method that electrolysis prepares metal nanoparticle
CN107290422B (en) * 2017-07-20 2019-04-19 浙江大学 A kind of biochemical detection system and method based on electrochemistry enhancing reflectance spectrum signal
TWI651095B (en) * 2017-10-18 2019-02-21 晶碩光學股份有限公司 Antiallergic ophthalmic product
CN111886004A (en) 2017-12-19 2020-11-03 纳米生物技术公司 Nanoparticles for the treatment of neuronal disorders
US11471482B2 (en) 2017-12-19 2022-10-18 Nanobiotix S.A. Nanoparticles for use in enhancing brain performances or in treating stress
EP3696534A1 (en) * 2019-02-14 2020-08-19 SmartDyeLivery GmbH Method for determining physicochemical properties of nanoscale systems (nss)
CN110905454B (en) * 2019-11-29 2022-01-04 南通仁隆科研仪器有限公司 Hydrate reservoir interwell electricity dynamic monitoring simulation experiment device
RU2725197C1 (en) * 2020-02-12 2020-06-30 федеральное государственное бюджетное образовательное учреждение высшего образования «Ижевская государственная медицинская академия» Министерства здравоохранения Российской Федерации Visceral hypersensitivity assessment method
KR102408166B1 (en) * 2020-04-02 2022-06-10 아주대학교산학협력단 Biosensing chip to analyze cell-derived materials during cell culture, and method for quantitative analysis of cell activity using the same
CN112571790A (en) * 2020-11-04 2021-03-30 即时智造科技(上海)有限公司 Automatic cooling device for SLS3D printing
CN112683710B (en) * 2020-12-02 2024-04-16 大连理工大学 Test device for accelerated corrosion of reinforced concrete bridge plate under chloride ion corrosion
CN115351289B (en) * 2022-09-01 2023-12-29 杭州师范大学 Method for preparing miniature gold nanorods by using ternary surfactant and product thereof

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR432101A (en) 1910-10-26 1911-11-29 I S Petzholdt Maschinen Fabrik Process and machine for processing fluid cocoa
JPS529615B1 (en) 1970-03-31 1977-03-17
JPS5747272B2 (en) 1974-12-13 1982-10-08
DE2854946A1 (en) 1978-12-20 1980-07-10 Agfa Gevaert Ag PHOTOGRAPHIC COLOR DIFFUSION TRANSFER PROCESS
US6638413B1 (en) 1989-10-10 2003-10-28 Lectro Press, Inc. Methods and apparatus for electrolysis of water
CA2104355C (en) 1993-08-18 1997-06-17 Ion I. Inculet Method and apparatus for ozone generation and treatment of water
DE19522619C2 (en) 1995-06-22 1998-11-12 Fischer & Krecke Gmbh & Co Process for the production of bottom bags with an internal bar
US5876663A (en) 1995-11-14 1999-03-02 The University Of Tennessee Research Corporation Sterilization of liquids using plasma glow discharge
ZA9610018B (en) 1995-11-28 1997-05-28 Austech Pty Ltd Liquid sterilisation apparatus
AUPO502297A0 (en) 1997-02-10 1997-03-06 Austech Pty Ltd Liquid purification apparatus
US5965994A (en) 1997-06-20 1999-10-12 Seo; Dong Il Automatic vertical moving systems and control methods therefor
US6558638B2 (en) 1998-03-14 2003-05-06 Splits Technologies Limited Treatment of liquids
US7527787B2 (en) * 2005-10-19 2009-05-05 Ibc Pharmaceuticals, Inc. Multivalent immunoglobulin-based bioactive assemblies
CA2272596A1 (en) 1999-05-21 2000-11-21 Lawrence A. Lambert Waste water treatment method and apparatus
US6214299B1 (en) 1999-06-01 2001-04-10 Robert J. Holladay Apparatus and method for producing antimicrobial silver solution
US7135195B2 (en) 1999-06-01 2006-11-14 American Silver, Llc Treatment of humans with colloidal silver composition
US7238472B2 (en) 2001-05-25 2007-07-03 Nanosphere, Inc. Non-alloying core shell nanoparticles
US6962679B2 (en) 2001-07-11 2005-11-08 Battelle Memorial Institute Processes and apparatuses for treating halogen-containing gases
US7135054B2 (en) 2001-09-26 2006-11-14 Northwestern University Nanoprisms and method of making them
TWI255695B (en) 2001-10-12 2006-06-01 Phild Co Ltd Method and device for producing ultrafine dispersion of noble metal
TW561085B (en) 2001-10-29 2003-11-11 Phild Co Ltd Method and device for producing metal powder
US7972390B2 (en) 2002-03-21 2011-07-05 Gr Intellectual Reserve, Llc Methods for controlling crystal growth, crystallization, structures and phases in materials and systems
GB0208263D0 (en) 2002-04-10 2002-05-22 Dow Corning Protective coating composition
US7118852B2 (en) 2002-04-11 2006-10-10 Throwleigh Technologies, L.L.C. Methods and apparatus for decontaminating fluids
US6749759B2 (en) 2002-07-12 2004-06-15 Wisconsin Alumni Research Foundation Method for disinfecting a dense fluid medium in a dense medium plasma reactor
US20040022702A1 (en) 2002-07-30 2004-02-05 Christensen Herbert E. Apparatus and method for automatically feeding the silver electrode into the solutiion
JP2004124155A (en) 2002-10-01 2004-04-22 Sumitomo Electric Ind Ltd Method and apparatus for manufacturing fine metal powder
US6802981B2 (en) 2002-11-05 2004-10-12 Aquapure Technologies Ltd. Method for purification and disinfection of water
WO2004073723A1 (en) * 2003-02-20 2004-09-02 She Tec Co., Ltd. Medical drug containing fine particle of noble metal
EP1613787A4 (en) 2003-04-02 2007-09-26 Univ Northwestern Methods of controlling nanoparticle growth
US20060249705A1 (en) 2003-04-08 2006-11-09 Xingwu Wang Novel composition
KR20060052913A (en) * 2003-07-28 2006-05-19 더 리전트 오브 더 유니버시티 오브 캘리포니아 Langmuir-blodgett nanostructure monolayers
WO2005023406A2 (en) 2003-09-10 2005-03-17 Ramot At Tel-Aviv University Ltd. Production of nanoparticles and microparticles
US7276283B2 (en) 2004-03-24 2007-10-02 Wisconsin Alumni Research Foundation Plasma-enhanced functionalization of carbon-containing substrates
US7486705B2 (en) 2004-03-31 2009-02-03 Imra America, Inc. Femtosecond laser processing system with process parameters, controls and feedback
US20060068026A1 (en) * 2004-08-11 2006-03-30 Hu Michael Z Thermal electrochemical synthesis method for production of stable colloids of "naked" metal nanocrystals
WO2006030605A1 (en) 2004-09-15 2006-03-23 Kyoto University Metal microparticle and process for producing the same
US20080089839A1 (en) * 2004-09-16 2008-04-17 Guo-Quan Lu Preparation of Stable High Concentration Coloidal Metal Particulate System
JP4614964B2 (en) * 2004-10-05 2011-01-19 アイノベックス株式会社 Composition for treatment or prevention of psychiatric symptoms
US8129199B2 (en) * 2004-12-13 2012-03-06 University of South Caroliina Surface enhanced Raman spectroscopy using shaped gold nanoparticles
NZ590025A (en) 2005-01-05 2012-06-29 Robert Holladay Silver/Water, Silver Gels and Silver-Based Compositions; and Methods for Making and Using the Same
WO2006099312A2 (en) * 2005-03-10 2006-09-21 Northwestern University Method of producing triangular or spherical gold nanoprisms starting from seeds
CN100467118C (en) 2005-08-08 2009-03-11 鸿富锦精密工业（深圳）有限公司 Preparation device of nanometer particle
KR100726713B1 (en) 2005-08-26 2007-06-12 한국전기연구원 Method for manufacturing nanostructured powder by wire explosion in liqiud and device for manufacturing the same
US8562803B2 (en) 2005-10-06 2013-10-22 Pionetics Corporation Electrochemical ion exchange treatment of fluids
US7758846B2 (en) * 2005-12-16 2010-07-20 Battelle Memorial Institute Methods of producing hydrogen via the water-gas shift reaction over a Pd-Zn catalyst
US20070267289A1 (en) 2006-04-06 2007-11-22 Harry Jabs Hydrogen production using plasma- based reformation
US8088193B2 (en) 2006-12-16 2012-01-03 Taofang Zeng Method for making nanoparticles
US7862782B2 (en) 2007-01-12 2011-01-04 Wisconsin Alumni Research Foundation Apparatus and methods for producing nanoparticles in a dense fluid medium
PT2178796T (en) * 2007-07-11 2021-03-29 Clene Nanomedicine Inc Continuous methods for treating liquids and manufacturing certain constituents (e.g., nanoparticles) in liquids, apparatuses and nanoparticles and nanoparticle/liquid solution(s) resulting therefrom
JP2009032756A (en) * 2007-07-25 2009-02-12 Sony Corp Semiconductor manufacturing apparatus
CN101952197A (en) 2008-01-14 2011-01-19 曾桃芳 Method for making nanoparticles or fine particles
EP2123262A1 (en) * 2008-05-20 2009-11-25 Consorzio per il Centro di Biomedica Moleculare Scrl Polyelectrolyte-encapsulated gold nanoparticles capable of crossing blood-brain barrier
DK2387478T3 (en) * 2009-01-15 2018-10-29 Clene Nanomedicine Inc CONTINUOUS PROCESS AND APPARATUS FOR THE CREATION OF GOLD-BASED NANOPARTICLES
US8246714B2 (en) 2009-01-30 2012-08-21 Imra America, Inc. Production of metal and metal-alloy nanoparticles with high repetition rate ultrafast pulsed laser ablation in liquids
SG10201403497QA (en) * 2009-07-08 2014-10-30 Gr Intellectual Reserve Llc Novel gold-based nanocrystals for medical treatments and electrochemical manufacturing processes therefor
EP2275137A1 (en) 2009-07-10 2011-01-19 Nanobiotix Metallic nanoparticles, preparation and uses thereof
US8858676B2 (en) 2010-02-10 2014-10-14 Imra America, Inc. Nanoparticle production in liquid with multiple-pulse ultrafast laser ablation
US8802234B2 (en) 2011-01-03 2014-08-12 Imra America, Inc. Composite nanoparticles and methods for making the same

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