DK2408913T3 - Neil3-peptider og vacciner, der indeholder disse - Google Patents

Neil3-peptider og vacciner, der indeholder disse Download PDF

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DK2408913T3
DK2408913T3 DK10753267.3T DK10753267T DK2408913T3 DK 2408913 T3 DK2408913 T3 DK 2408913T3 DK 10753267 T DK10753267 T DK 10753267T DK 2408913 T3 DK2408913 T3 DK 2408913T3
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peptide
neil3
cancer
seq
peptides
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Takuya Tsunoda
Ryuji Ohsawa
Sachiko Yoshimura
Tomohisa Watanabe
Yusuke Nakamura
Yoichi Furukawa
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Oncotherapy Science Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
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    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/99—Other carbon-oxygen lyases (4.2.99)
    • C12Y402/99018—DNA-(apurinic or apyrimidinic site)lyase (4.2.99.18)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Claims (22)

1. Isoleret peptid på mindre end 15 aminosyrer udvalgt fra gruppen, der består af (i) og (ii) nedenfor: (i) et isoleret peptid ifølge (a) eller (b) nedenfor: (a) et isoleret peptid, der omfatter en aminosyresekvens udvalgt fra gruppen, der består af SEQ ID NO: 24, 33, 35, 41 og 43; (b) et isoleret peptid, der består af en aminosyresekvens udvalgt fra gruppen, der består af SEQ ID NO: 24, 33, 35, 41 og 43, hvori 1 eller 2 aminosyre(r) er substitueret, deleteret eller tilføjet, hvor peptidet har CTL-inducerbarhed; og (ii) et isoleret peptid ifølge (c) eller (d) nedenfor: (c) et isoleret peptid, der omfatter en aminosyresekvens udvalgt fra gruppen, der består af SEQ ID NO: 5, 3, 4, 6, 11, 15, 17, 21 og 22; (d) et isoleret peptid, der består af en aminosyresekvens udvalgt fra gruppen, der består af SEQ ID NO: 5, 3, 4, 6, 11, 15, 17, 21 og 22, hvori 1 eller 2 aminosyre (r) er substitueret, deleteret eller tilføjet, hvor peptidet har CTL-inducerbarhed.
2. Isoleret peptid ifølge krav 1, hvor peptidet har den ene eller begge af følgende egenskaber: (a) den anden aminosyre fra N-terminalen af aminosyresekvensen ifølge SEQ ID NO: 24, 33, 35, 41 eller 43 er substitueret med aminosyren udvalgt fra gruppen, der består af phenylalanin, tyrosin, methionin og tryptofan; og (b) den C-terminale aminosyre af aminosyresekvensen ifølge SEQ ID NO: 24, 33, 35, 41 eller 43 er substitueret med aminosyren udvalgt fra gruppen, der består af phenylalanin, leucin, isoleucin, tryptofan og methionin.
3. Isoleret peptid ifølge krav 1, hvor peptidet har den ene eller begge af følgende egenskaber: (a) den anden aminosyre fra N-terminalen af aminosyresekvensen ifølge SEQ ID NO: 5, 3, 4, 6, 11, 15, 17, 21 eller 22 er substitueret med aminosyren udvalgt fra gruppen, der består af leucin og methionin; og (b) den C-terminale aminosyre af aminosyresekvensen ifølge SEQ ID NO: 5, 3, 4, 6, 11, 15, 17, 21 eller 22 er substitueret med aminosyren udvalgt fra gruppen, der består af valin og leucin.
4. Isoleret peptid ifølge et hvilket som helst af kravene 1 til 3, som er et nonapeptid eller dekapeptid.
5. Isoleret peptid ifølge krav 1 eller 4, hvor peptidet består af aminosyresekvensen udvalgt fra gruppen, der består af SEQ ID NO: 5, 3, 4, 6, 11, 15, 17, 21, 22, 24, 33, 35, 41 og 43.
6. Isoleret polynukleotid, der koder for peptidet ifølge et hvilket som helst af kravene 1 til 5.
7. Sammensætning, der omfatter et eller flere peptid(er) ifølge et hvilket som helst af kravene 1 til 5 eller et eller flere polynukleotid(er) ifølge krav 6.
8. Farmaceutisk sammensætning, der omfatter et eller flere peptid(er) ifølge et hvilket som helst af kravene 1 til 5 eller et eller flere polynukleotid(er) ifølge krav 6.
9. Peptid ifølge et hvilket som helst af kravene 1 til 5, polynukleotid ifølge krav 6 eller sammensætning ifølge krav 7 eller 8 til anvendelse som et medikament.
10. Peptid ifølge et hvilket som helst af kravene 1 til 5, polynukleotid ifølge krav 6 eller sammensætning ifølge krav 7 eller 8 til anvendelse til behandling eller forebyggelse af cancer og/eller forebyggelse af postoperativt recidiv deraf.
11. Peptid, polynukleotid eller sammensætning til anvendelse til behandling eller forebyggelse af cancer og/eller forebyggelse af postoperativt recidiv deraf ifølge krav 10 til administration til et indvid, hvis HLA-antigen er HLA-A24 eller HLA-A2.
12. In vitro-fremgangsmåde til inducering af en antigenpræsenterende celle (APC), der er CTL-inducerbar, som omfatter et trin udvalgt fra gruppen, der består af: (a) etablering af kontakt mellem en APC og peptidet ifølge et hvilket som helst af kravene 1 til 5 in vitro og (b) indførelse af et polynukleotid, der koder for peptidet ifølge et hvilket som helst af kravene 1 til 5, i en APC in vitro.
13. In vitro-fremgangsmåde til inducering af CTL ved hjælp af fremgangsmåden, der omfatter et trin udvalgt fra gruppen, der består af: (a) dyrkning af CD8-positive T-celler sammen med APC'er, som på deres overflade præsenterer et kompleks af et HLA-antigen og et peptid ifølge et hvilket som helst af kravene 1 til 5; (b) dyrkning af CD8-positive T-celler sammen med exosomer, som på deres overflade præsenterer et kompleks af et HLA-antigen og et peptid ifølge et hvilket som helst af kravene 1 til 5; og (c) indførelse af et gen, der omfatter et polynukleotid, der koder for et T-cellereceptor (TCR)-subunitpolypeptid, der binder til peptidet ifølge et hvilket som helst af kravene 1 til 5, i en T-celle.
14. Isoleret APC, der på dens overflade præsenterer et kompleks af et HLA-antigen og peptidet ifølge et hvilket som helst af kravene 1 til 5.
15. APC ifølge krav 14, som er induceret ved hjælp af fremgangsmåden ifølge krav 12.
16. Isoleret CTL, der er målrettet mod peptidet ifølge et hvilket som helst af kravene 1 til 5.
17. CTL ifølge krav 16, som er induceret ved hjælp af fremgangsmåden ifølge krav 13.
18. Exosom, der præsenterer et kompleks, som omfatter peptidet ifølge et hvilket som helst af kravene 1 til 5 og et HLA-antigen.
19. Antistof eller fragment deraf mod peptidet ifølge et hvilket som helst af kravene 1 til 5.
20. Vektor, der omfatter en nukleotidsekvens, der koder for peptiderne ifølge et hvilket som helst af kravene 1 til 5.
21. Værtscelle, der er transformeret eller transficeret med en ekspressionvektor ifølge krav 20.
22. Diagnostisk kit, der omfatter peptidet ifølge et hvilket som helst af kravene 1 til 5, polynukleotidet ifølge krav 6 eller antistoffet ifølge krav 19.
DK10753267.3T 2009-03-18 2010-03-15 Neil3-peptider og vacciner, der indeholder disse DK2408913T3 (da)

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EP (1) EP2408913B1 (da)
JP (3) JP5799394B2 (da)
KR (1) KR101744514B1 (da)
CN (2) CN102356155B (da)
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RU2570560C2 (ru) 2010-03-11 2015-12-10 Онкотерапи Сайенс, Инк. Пептиды hjurp и содержащие их вакцины
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