DK2395993T3 - Hudbebehandling - Google Patents
Hudbebehandling Download PDFInfo
- Publication number
- DK2395993T3 DK2395993T3 DK10740847.8T DK10740847T DK2395993T3 DK 2395993 T3 DK2395993 T3 DK 2395993T3 DK 10740847 T DK10740847 T DK 10740847T DK 2395993 T3 DK2395993 T3 DK 2395993T3
- Authority
- DK
- Denmark
- Prior art keywords
- euphorbia
- optionally substituted
- ingenol
- pep005
- alkyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Claims (9)
1. Fremgangsmåde til kosmetisk behandling af tidsældet og/eller fotoældet ikke-sygdomsramt hud hos en person omfattende administration til personens hud af en isoleret ingenolforbindelse eller et farmaceutisk acceptabelt salt deraf, hvor ingenolforbindelsen har formlen:
hvor R1 er udvalgt fra eventuelt substitueret alkyl, eventuelt substitueret alkenyl, eventuelt substitueret alkynyl, eventuelt substitueret acyl, eventuelt substitueret aryl, eventuelt substitueret arylalkyl, S(0)2R', S(0)20R', P(0)(0R')2 (hvor R' er hydrogen, alkyl, alkenyl, alkynyl, acyl, aryl eller arylalkyl) og glycosyl og R2-R3 uafhængigt er udvalgt fra hydrogen, eventuelt substitueret alkyl, eventuelt substitueret alkenyl, eventuelt substitueret alkynyl, eventuelt substitueret acyl, eventuelt substitueret aryl, eventuelt substitueret arylalkyl, S(0)2R’, S(0)20R', P(0)(0R')2 (hvor R' er hydrogen, alkyl, alkenyl, alkynyl, acyl, aryl, eller arylalkyl) og glycosyl eller R1 og R2 eller R2 og R3 kan danne en methylen- eller ethylenkæde; og R4 er udvalgt fra hydrogen, hydroxy, eventuelt substitueret alkoxy, eventuelt substitueret alkenoxy, eventuelt substitueret alkynoxy, eventuelt substitueret acyloxy, eventuelt substitueret arylalkoxy, 0S(0)2R', 0S(0)20R', 0P(0)(0R')2 (hvor R' er hydrogen, alkyl, alkenyl, alkynyl, acyl, aryl eller arylalkyl) og glycoxy, hvor eventuelle substituenter for alkyl, alkenyl, alkynyl, aryl, arylalkyl, aryl og dermed acyl, indbefatter: halo(chlor, brom, iod og fluor), hydroxyl, Ci-6-alkoxy, Ci-6-alkyl, C3-6-cycloalkyl, phenyl, nitro, halomethyl (f.eks. tribrommethyl, trichlormethyl, trifluormethyl), halomethoxy (f.eks. trifluormethoxy, tribrommethoxy), C(0)Ci-6-alkyl, amino(NH2), C1-6- alkylamino, (f.eks. methylamino, ethylamino og propylamino) diCi-6-alkylamino (f.eks. dimethylamino, diethylamino og dipropylamino), CO2H, C02Ci_6-alkyl, thio(SH) og C1-6-alkylthio, og indbefatter udskiftningen af en CH2-gruppe med en carbonyl (C=0)-gruppe eller kan være en methylen- eller ethylendioxy-gruppe.
2. Fremgangsmåde ifølge krav 1, hvor R1 er en angeloylgruppe.
3. Fremgangsmåde ifølge krav 2, hvor ingenolforbindelsen er udvalgt fra gruppen bestående af ingenol-3-angelat, 20-O-acetyl-ingenol-3-angelat og 20-deoxy-ingenol-3-angelat.
4. Fremgangsmåde ifølge krav 3, hvor ingenolforbindelsen er ingenol-3-angelat.
5. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 4, hvor ingenolforbindelsen administreres på et hudområde på mindst 10 cm2.
6. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 5, hvor ingenolforbindelsen administreres på ansigtet og/eller nakken og/eller halsen og/eller området omkring øjnene.
7. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 6, hvor ingenolforbindelsen administreres topisk på huden.
8. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 7, hvor ingenolforbindelsen administreres i form af en isopropylalkoholbaseret gel eller en makrocetylethercreme.
9. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 8, hvor behandlingen er beregnet til forbedring af det kosmetiske udseende af fine linjer eller og/eller UV-ældning.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15259909P | 2009-02-13 | 2009-02-13 | |
| PCT/AU2010/000152 WO2010091472A1 (en) | 2009-02-13 | 2010-02-12 | Skin treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2395993T3 true DK2395993T3 (da) | 2017-08-07 |
Family
ID=42561329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10740847.8T DK2395993T3 (da) | 2009-02-13 | 2010-02-12 | Hudbebehandling |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10143638B2 (da) |
| EP (1) | EP2395993B1 (da) |
| JP (1) | JP5638008B2 (da) |
| CN (1) | CN102316866A (da) |
| AU (1) | AU2010213362B2 (da) |
| CA (1) | CA2752389C (da) |
| DK (1) | DK2395993T3 (da) |
| ES (1) | ES2633755T3 (da) |
| IL (1) | IL214133A (da) |
| NZ (1) | NZ594184A (da) |
| PL (1) | PL2395993T3 (da) |
| PT (1) | PT2395993T (da) |
| RU (1) | RU2491050C2 (da) |
| WO (1) | WO2010091472A1 (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012080466A2 (en) | 2010-12-17 | 2012-06-21 | Leo Pharma A/S | Ingenols for treating seborrheic keratosis |
| EP2655312A1 (en) | 2010-12-22 | 2013-10-30 | Leo Laboratories Limited | 3-acyl-ingenols ii |
| US9388124B2 (en) | 2010-12-22 | 2016-07-12 | Leo Laboratories Limited | Ingenol-3-acylates I |
| WO2012176015A1 (en) | 2011-06-24 | 2012-12-27 | Leo Pharma A/S | Methods for treating uv-damaged skin and scc tumors and for removing tattoos with topical ingenol mebutate |
| EP2790669A1 (en) * | 2011-12-12 | 2014-10-22 | Leo Laboratories Limited | A topical composition comprising an ingenol derivative and an oily solvent |
| US20140350101A1 (en) * | 2011-12-12 | 2014-11-27 | Leo Laboratories Limited | Gel compositions |
| WO2014158858A1 (en) * | 2013-03-13 | 2014-10-02 | Avon Products, Inc | Glochidium wallichianum extracts and methods of use |
| AU2014100280B4 (en) * | 2014-03-24 | 2015-01-15 | Leo Pharma A/S | A method of treating skin lesions |
| US9526714B2 (en) | 2014-03-24 | 2016-12-27 | Leo Laboratories Limited | Method for treating skin lesions with ingenol mebutate |
| BR112018074202B1 (pt) * | 2016-05-24 | 2022-08-02 | Natura Cosméticos S.A | Composição cosmética antissinais, kit de composições e método para tratamento cosmético da pele |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08176004A (ja) | 1994-12-21 | 1996-07-09 | Lion Corp | 生体老化防止剤及び皮膚用組成物 |
| JPH0987136A (ja) * | 1995-07-13 | 1997-03-31 | Shiseido Co Ltd | 皮膚外用剤 |
| AU750624B2 (en) * | 1997-08-19 | 2002-07-25 | Leo Laboratories Limited | Anti-cancer compounds-I |
| AUPO864097A0 (en) * | 1997-08-19 | 1997-09-11 | Peplin Pty Ltd | Anti-cancer compounds |
| KR20010057776A (ko) * | 1999-12-23 | 2001-07-05 | 성재갑 | 피부미백제 |
| JP4880816B2 (ja) * | 2000-12-15 | 2012-02-22 | 株式会社ヤクルト本社 | 皮膚老化防止剤 |
| JP3935360B2 (ja) * | 2002-01-22 | 2007-06-20 | 丸善製薬株式会社 | ヒアルロン酸産生促進剤並びに皮膚化粧料及び美容用飲食品 |
| RU2229293C1 (ru) * | 2003-04-24 | 2004-05-27 | Хазанов Вениамин Абрамович | Лечебно-профилактическое средство для использования в геронтологической практике |
| US20070224150A1 (en) * | 2005-03-24 | 2007-09-27 | Yongji Chung | Growth factor for hair and skin treatment |
| JP2007084448A (ja) * | 2005-09-20 | 2007-04-05 | Shiseido Co Ltd | ヒアルロン酸産生促進剤および皮膚外用剤 |
| BRPI0504797B1 (pt) * | 2005-10-27 | 2020-02-04 | Pele Nova Biotecnologia S A | formulação tópica, método de tratamento cosmético para rejuvenescimento da pele, método de tratamento cosmético e uso de uma formulação |
| CA2629899A1 (en) * | 2005-11-25 | 2007-05-31 | Peplin Research Pty Ltd | Methods for wound healing |
| MX2009011865A (es) * | 2007-04-30 | 2009-12-04 | Peplin Research Pty Ltd | Tratamiento de lesiones viralmente inducidas. |
| RS56337B1 (sr) * | 2010-04-16 | 2017-12-29 | Leo Pharma As | Ortorombični kristalni ingenol mebutat |
-
2010
- 2010-02-12 ES ES10740847.8T patent/ES2633755T3/es active Active
- 2010-02-12 EP EP10740847.8A patent/EP2395993B1/en not_active Not-in-force
- 2010-02-12 NZ NZ594184A patent/NZ594184A/en not_active IP Right Cessation
- 2010-02-12 CA CA2752389A patent/CA2752389C/en not_active Expired - Fee Related
- 2010-02-12 US US13/201,331 patent/US10143638B2/en not_active Expired - Fee Related
- 2010-02-12 WO PCT/AU2010/000152 patent/WO2010091472A1/en active Application Filing
- 2010-02-12 JP JP2011549394A patent/JP5638008B2/ja not_active Expired - Fee Related
- 2010-02-12 DK DK10740847.8T patent/DK2395993T3/da active
- 2010-02-12 AU AU2010213362A patent/AU2010213362B2/en not_active Ceased
- 2010-02-12 PL PL10740847T patent/PL2395993T3/pl unknown
- 2010-02-12 CN CN2010800074880A patent/CN102316866A/zh active Pending
- 2010-02-12 RU RU2011137530/15A patent/RU2491050C2/ru not_active IP Right Cessation
- 2010-02-12 PT PT107408478T patent/PT2395993T/pt unknown
-
2011
- 2011-07-18 IL IL214133A patent/IL214133A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| PT2395993T (pt) | 2017-07-18 |
| CN102316866A (zh) | 2012-01-11 |
| CA2752389A1 (en) | 2010-08-19 |
| CA2752389C (en) | 2017-01-03 |
| EP2395993B1 (en) | 2017-06-21 |
| EP2395993A4 (en) | 2014-09-03 |
| AU2010213362A1 (en) | 2011-08-04 |
| JP5638008B2 (ja) | 2014-12-10 |
| AU2010213362B2 (en) | 2015-07-02 |
| ES2633755T3 (es) | 2017-09-25 |
| PL2395993T3 (pl) | 2017-10-31 |
| US20120041064A1 (en) | 2012-02-16 |
| IL214133A0 (en) | 2011-08-31 |
| RU2011137530A (ru) | 2013-03-20 |
| EP2395993A1 (en) | 2011-12-21 |
| IL214133A (en) | 2015-03-31 |
| US10143638B2 (en) | 2018-12-04 |
| NZ594184A (en) | 2014-01-31 |
| JP2012517450A (ja) | 2012-08-02 |
| WO2010091472A1 (en) | 2010-08-19 |
| RU2491050C2 (ru) | 2013-08-27 |
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