DK2386860T3 - Forudsigelse af mortalitet og påvisning af svær sygdom - Google Patents

Forudsigelse af mortalitet og påvisning af svær sygdom Download PDF

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DK2386860T3
DK2386860T3 DK11177461.8T DK11177461T DK2386860T3 DK 2386860 T3 DK2386860 T3 DK 2386860T3 DK 11177461 T DK11177461 T DK 11177461T DK 2386860 T3 DK2386860 T3 DK 2386860T3
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James V Snider
Sven Jacobson
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Critical Care Diagnostics Inc
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    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16Z—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
    • G01N2333/7155—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/12—Pulmonary diseases
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

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Claims (15)

  1. FORUDSIGELSE AF MORTALITET OG PÅVISNING AF SVÆR SYGDOM
    1. In vitro-fremgangsmåde til udvælgelse af en behandling for et individ ved bestemmelse af et niveau af opløselig ST2, som indikerer et individs dødsrisiko, hvilken fremgangsmåde omfatter: bestemmelse af et niveau af opløselig ST2 i en biologisk prøve fra et individ på et første tidspunkt; bestemmelse af et niveau af opløselig ST2 i en biologisk prøve fra et individ på et andet tidspunkt; og (a) identificering af et individ, som har et forhold mellem niveauet af opløselig ST2 på det andet tidspunkt og niveauet af opløselig ST2 på det første tidspunkt, der er forhøjet i sammenligning med et referenceforhold, og udvælgelse af hospitalsindlæggelse for individet og udvælgelse af kateterisation og/eller billeddannelsesundersøgelser for individet i tilfælde af mistanke om myokardieinfarkt; eller (b) identificering af et individ, som har et forhold mellem niveauet af opløselig ST2 på det andet tidspunkt og niveauet af opløselig ST2 på det første tidspunkt, der er nedsat i sammenligning med et referenceforhold, og udvælgelse af ambulant behandling for individet.
  2. 2. Fremgangsmåde ifølge krav 1, hvor der udvælges kateterisation i tilfælde af mistanke om myokardieinfarkt.
  3. 3. Fremgangsmåde ifølge krav 1, hvor der udvælges omfattende billeddannelsesundersøgelser i tilfælde af mistanke om myokardieinfarkt.
  4. 4. Fremgangsmåde ifølge krav 1, hvor der udvælges kateterisation og omfattende billeddannelsesundersøgelser i tilfælde af mistanke om myokardieinfarkt.
  5. 5. Fremgangsmåde ifølge krav 1, hvor der udvælges hospitalsindlæggelse for et individ, som har et forhold mellem niveauet af opløselig ST2 på det andet tidspunkt og niveauet af opløselig ST2 på det første tidspunkt, der er forhøjet i sammenligning med et referenceforhold.
  6. 6. Fremgangsmåde ifølge krav 1, hvor der udvælges ambulant behandling for et individ, som har et forhold mellem niveauet af opløselig ST2 på det andet tidspunkt og niveauet af opløselig ST2 på det første tidspunkt, der er nedsat i sammenligning med et referenceforhold.
  7. 7. Fremgangsmåde ifølge krav 1, hvor individet allerede er i behandling, og hospitalsindlæggelsen, hjertekateterisationen, billeddannelsesundersøgelserne og/eller den ambulante behandling er en alternativ behandling.
  8. 8. Fremgangsmåde ifølge krav 1, hvor der mindst er to dage mellem det første tidspunkt og det andet tidspunkt.
  9. 9. Fremgangsmåde ifølge krav 1, hvor referenceforholdet er et tærskelforhold.
  10. 10. Fremgangsmåde ifølge krav 1, hvor der udvælges billeddannelsesundersøgelser for et individ, som har et forhold mellem niveauet af opløselig ST2 på det andet tidspunkt og niveauet af opløselig ST2 på det første tidspunkt, der er forhøjet i sammenligning med et referenceforhold.
  11. 11. Fremgangsmåde ifølge krav 1, hvilken fremgangsmåde endvidere omfatter bestemmelse af et niveau af en eller flere yderligere biomarkører udvalgt fra gruppen af: et kardialt troponin, såsom kardialt troponin I og kardialt troponin T; et B-type natriuretisk peptid, såsom N-terminalt proBNP eller proBNP; et atrialt natriuretisk peptid (ANP), såsom N-terminalt proANP og proANP; C-reaktivt peptid; blodureanitrogen; D-dimerer; albumin; leverfunktionsenzymer; creatinin og bakterielt endotoksin.
  12. 12. Fremgangsmåde ifølge krav 1, hvor individet ikke har en kardiovaskulær sygdom; har en lungesygdom, såsom lungebetændelse, kronisk obstruktiv lungesygdom og lungeemboli; eller har en leversygdom, såsom leversygdom associeret med kemoterapi, alkoholtoksicitet eller lægemiddeltoksicitet.
  13. 13. Fremgangsmåde ifølge krav 1, hvor individet har et BMI på 25-29 eller > 30; har nedsat nyrefunktion; eller har hypertension.
  14. 14. Fremgangsmåde ifølge krav 1, hvor individet har et eller flere uspecifikke symptomer, såsom brystsmerter eller -ubehag, dyspnø, kvalme, opkastning, opstød, svedeture, palpitationer, uklarhed, træthed og besvimelse.
  15. 15. Fremgangsmåde ifølge krav 1, hvor den biologiske prøve eller de biologiske prøver er serum, plasma eller blod.
DK11177461.8T 2006-04-24 2007-04-24 Forudsigelse af mortalitet og påvisning af svær sygdom DK2386860T3 (da)

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US79435406P 2006-04-24 2006-04-24
US80036206P 2006-05-15 2006-05-15
US90460807P 2007-03-02 2007-03-02
EP10171764A EP2241888B1 (en) 2006-04-24 2007-04-24 Predicting mortality and detecting severe disease

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DK10171764.3T DK2241888T3 (da) 2006-04-24 2007-04-24 Forudsigelse af mortalitet og påvisning af svær sygdom
DK11177461.8T DK2386860T3 (da) 2006-04-24 2007-04-24 Forudsigelse af mortalitet og påvisning af svær sygdom
DK14188319.9T DK2848938T3 (da) 2006-04-24 2007-04-24 Evaluering af effektiviteten af en behandling hos et individ baseret på st2- niveauer

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AU (1) AU2007244927B2 (da)
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