DK2381970T3 - Silikat-substitueret hydroxyapatit - Google Patents

Silikat-substitueret hydroxyapatit Download PDF

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Publication number
DK2381970T3
DK2381970T3 DK09796031.4T DK09796031T DK2381970T3 DK 2381970 T3 DK2381970 T3 DK 2381970T3 DK 09796031 T DK09796031 T DK 09796031T DK 2381970 T3 DK2381970 T3 DK 2381970T3
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DK
Denmark
Prior art keywords
hydroxyapatite
silicate
molar ratio
range
calcium
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Application number
DK09796031.4T
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English (en)
Inventor
Lain Ronald Gibson
Janet Mabel Scott Skakle
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Sirakoss Ltd
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Publication date
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Publication of DK2381970T3 publication Critical patent/DK2381970T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • C01B25/322—Preparation by neutralisation of orthophosphoric acid

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)
  • Prostheses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)

Claims (15)

1. Uorganisk silikat-substitueret calciumphosphathydroxyapatit, som har et Ca/P-molforhold i området 2,05 til 2,55 og et Ca/(P+Si)-molforhold på mindre end 1,66.
2. Hydroxyapatit ifølge krav 1, hvor silikoneatomindholdet ligger i området 2,9 til 6 vægt-%.
3. Hydroxyapatit ifølge krav 1 eller 2, hvor hydroxyapatitten er i det væsentlige fri for urenhedsfaser.
4. Hydroxyapatit ifølge et af kravene 1 til 3 i krystallinsk form.
5. Hydroxyapatit ifølge krav 4, hvor den gennemsnitlige længdeakselængde af krystallitten ligger i området 0,05 til 5 pm.
6. Hydroxyapatit ifølge et af kravene 1 til 5, hvor Ca/(P+Si)-molforholdet ligger i området 1,60 til 1,65.
7. Hydroxyapatit ifølge et af kravene 1 til 6, som er i det væsentlige fri for carbonat-ioner.
8. Fremgangsmåde til fremstilling af et uorganisk silikat-substitueret calciumphosphathydroxyapatit, omfattende: (a) udfældning af silikat-substitueret apatit fra reagenser indeholdende calcium, phosphor og silikone med en pH-værdi på mindst 9, hvor Ca/P-molforholdet af reagenserne ligger i området 2,05 til 2,55, og Ca/(P + Si)-molforholdet er mindre end 1,66, og (b) calcinering af udfældningsproduktet ved en temperatur i området 400 til 1050°C.
9. Fremgangsmåde ifølge krav 8, hvor silikoneatomindholdet af reagenserne ligger i området 2,9 til 6 vægt-%.
10. Fremgangsmåde ifølge krav 8 eller 9, hvor reagenserne omfatter calciumoxid eller calciumhydroxid, hvilket resulterer i, at udfældningsreaktionen holdes på en pH-værdi på mindst 10.
11. Fremgangsmåde ifølge et af kravene 8 til 10, hvor reagenserne omfatter et phosphorholdigt reagens, som er et phosphatsalt eller en phosphatsyre.
12. Fremgangsmåde ifølge et af kravene 8 til 11, hvor reagenserne omfatter et et silikoneholdigt reagens, som er en organosilikoneforbindelse, et silicat-salt eller en silicatsyre.
13. Fremgangsmåde ifølge et af kravene 8 til 12, hvor calcineringstemperatu-ren ligger i området fra 600 til 1000°C, fortrinsvis i området fra 700 til 900°C.
14. Biomedicinsk materiale indeholdende en hydroxyapatit ifølge et af kravene 1 til 7.
15. Medicinsk indretning indeholdende en hydroxyapatit ifølge et af kravene 1 til 7.
DK09796031.4T 2009-01-08 2009-12-23 Silikat-substitueret hydroxyapatit DK2381970T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0900269.2A GB0900269D0 (en) 2009-01-08 2009-01-08 Silicate-substituted hydroxyapatite
PCT/GB2009/002954 WO2010079316A1 (en) 2009-01-08 2009-12-23 Silicate- substituted hydroxyapatite

Publications (1)

Publication Number Publication Date
DK2381970T3 true DK2381970T3 (da) 2017-07-03

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Family Applications (1)

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DK09796031.4T DK2381970T3 (da) 2009-01-08 2009-12-23 Silikat-substitueret hydroxyapatit

Country Status (13)

Country Link
US (1) US8545895B2 (da)
EP (1) EP2381970B1 (da)
JP (1) JP5740314B2 (da)
AU (1) AU2009336612B8 (da)
CA (1) CA2749018C (da)
DK (1) DK2381970T3 (da)
ES (1) ES2632171T3 (da)
GB (1) GB0900269D0 (da)
HU (1) HUE033614T2 (da)
PL (1) PL2381970T3 (da)
PT (1) PT2381970T (da)
SI (1) SI2381970T1 (da)
WO (1) WO2010079316A1 (da)

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Also Published As

Publication number Publication date
CA2749018C (en) 2018-01-23
JP2012514573A (ja) 2012-06-28
EP2381970A1 (en) 2011-11-02
US20100173009A1 (en) 2010-07-08
WO2010079316A1 (en) 2010-07-15
PT2381970T (pt) 2017-07-13
EP2381970B1 (en) 2017-04-12
US8545895B2 (en) 2013-10-01
PL2381970T3 (pl) 2017-09-29
HUE033614T2 (hu) 2017-12-28
AU2009336612A1 (en) 2011-08-25
AU2009336612A8 (en) 2015-11-05
SI2381970T1 (sl) 2017-08-31
JP5740314B2 (ja) 2015-06-24
AU2009336612B8 (en) 2015-11-05
GB0900269D0 (en) 2009-02-11
ES2632171T3 (es) 2017-09-11
CA2749018A1 (en) 2010-07-15
AU2009336612B2 (en) 2015-07-16

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