DK235889A - Derivater af 6-phenyl-3-piperazinylalkyl-1h,3h-pyrimidindion-2,4, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse - Google Patents

Derivater af 6-phenyl-3-piperazinylalkyl-1h,3h-pyrimidindion-2,4, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse Download PDF

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Publication number
DK235889A
DK235889A DK235889A DK235889A DK235889A DK 235889 A DK235889 A DK 235889A DK 235889 A DK235889 A DK 235889A DK 235889 A DK235889 A DK 235889A DK 235889 A DK235889 A DK 235889A
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Prior art keywords
denotes
compounds
pyrimidindion
piperazinylalkyl
phenyl
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DK235889A
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Danish (da)
English (en)
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DK235889D0 (da
Inventor
Jonathan Frost
Bernard Gaudilliere
Jean Rousseau
Regis Dupont
Philippe Manoury
Daniel Obitz
Original Assignee
Synthelabo
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Application filed by Synthelabo filed Critical Synthelabo
Publication of DK235889D0 publication Critical patent/DK235889D0/da
Publication of DK235889A publication Critical patent/DK235889A/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Indole Compounds (AREA)
DK235889A 1988-05-17 1989-05-16 Derivater af 6-phenyl-3-piperazinylalkyl-1h,3h-pyrimidindion-2,4, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse DK235889A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8806568A FR2631625B1 (fr) 1988-05-17 1988-05-17 Derives de phenyl-6 piperazinylalkyl-3 1h,3h-pyrimidinedione-2,4, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
DK235889D0 DK235889D0 (da) 1989-05-16
DK235889A true DK235889A (da) 1989-11-17

Family

ID=9366355

Family Applications (1)

Application Number Title Priority Date Filing Date
DK235889A DK235889A (da) 1988-05-17 1989-05-16 Derivater af 6-phenyl-3-piperazinylalkyl-1h,3h-pyrimidindion-2,4, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse

Country Status (20)

Country Link
US (1) US4950670A (de)
EP (1) EP0343050B1 (de)
JP (1) JPH02138266A (de)
KR (1) KR890017244A (de)
AT (1) ATE82969T1 (de)
AU (1) AU614135B2 (de)
CA (1) CA1327577C (de)
DE (1) DE68903680T2 (de)
DK (1) DK235889A (de)
ES (1) ES2045485T3 (de)
FI (1) FI892344A (de)
FR (1) FR2631625B1 (de)
GR (1) GR3007118T3 (de)
HU (1) HU201057B (de)
IE (1) IE891579L (de)
IL (1) IL90309A (de)
NO (1) NO172437C (de)
NZ (1) NZ229144A (de)
PT (1) PT90572B (de)
ZA (1) ZA893651B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2655988B1 (fr) * 1989-12-20 1994-05-20 Adir Cie Nouveaux derives de la napht-1-yl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
GB9012311D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
JP3329534B2 (ja) * 1993-10-20 2002-09-30 株式会社東海理化電機製作所 シフトレバー装置
DE4425143A1 (de) * 1994-07-15 1996-01-18 Basf Ag Substituierte Pyrimidinverbindungen und deren Verwendung
US6306909B1 (en) 1997-03-12 2001-10-23 Queen's University At Kingston Anti-epileptogenic agents
ATE228119T1 (de) 1998-04-15 2002-12-15 Pfizer Prod Inc Heterocyclische carboxamide
MXPA02006848A (es) * 2000-01-25 2002-12-13 Neurocrine Bioscience Inc Antagonistas del receptor de la hormona liberadora de gonadotropina.
US7501429B2 (en) * 2001-04-11 2009-03-10 Queen's University At Kingston Pyrimidine compounds as anti-ictogenic and/or anti-epileptogenic agents
CA2448160A1 (en) * 2001-05-25 2002-12-05 Queen's University At Kingston Heterocyclic beta-amino acids and their use as anti-epileptogenic agents
AU2005217320B2 (en) 2004-02-26 2011-07-21 Aska Pharmaceuticals Co., Ltd. Pyrimidine derivative
UA85871C2 (uk) * 2004-03-15 2009-03-10 Такеда Фармасьютікал Компані Лімітед Інгібітори дипептидилпептидази
JP2008500383A (ja) * 2004-05-21 2008-01-10 ファイザー・プロダクツ・インク 5−ht1bアンタゴニスト、インバースアゴニストおよび部分アゴニストとしてのテトラヒドロナフチルピペラジン類
KR102103768B1 (ko) 2018-04-04 2020-04-23 한양대학교 에리카산학협력단 5-ht2c 항진제로서의 활성을 가지는 광학 활성의 2-아미노-4-알콕시 피리미딘 유도체

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4625028A (en) * 1983-07-11 1986-11-25 The Upjohn Company 6-aryluracils and selected novel intermediates used in the preparation thereof
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
US4845221A (en) * 1988-04-15 1989-07-04 American Home Products Corporation Serotonergic substituted piperazinyl tetralins

Also Published As

Publication number Publication date
AU3484389A (en) 1989-11-23
EP0343050B1 (de) 1992-12-02
KR890017244A (ko) 1989-12-15
US4950670A (en) 1990-08-21
EP0343050A1 (de) 1989-11-23
ATE82969T1 (de) 1992-12-15
NO172437C (no) 1993-07-21
FR2631625B1 (fr) 1992-10-16
IL90309A (en) 1994-02-27
JPH02138266A (ja) 1990-05-28
DE68903680T2 (de) 1993-06-17
HU201057B (en) 1990-09-28
NO891949D0 (no) 1989-05-16
PT90572B (pt) 1994-08-31
CA1327577C (en) 1994-03-08
FI892344A0 (fi) 1989-05-16
AU614135B2 (en) 1991-08-22
NZ229144A (en) 1990-10-26
IE891579L (en) 1989-11-16
PT90572A (pt) 1989-11-30
ES2045485T3 (es) 1994-01-16
GR3007118T3 (de) 1993-07-30
DE68903680D1 (de) 1993-01-14
DK235889D0 (da) 1989-05-16
NO172437B (no) 1993-04-13
HUT50164A (en) 1989-12-28
IL90309A0 (en) 1989-12-15
FR2631625A1 (fr) 1989-11-24
ZA893651B (en) 1990-01-31
NO891949L (no) 1989-11-20
FI892344A (fi) 1989-11-18

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