DK2344178T3 - Peptidsekvenser, deres forgrenede form og anvendelse deraf til antimikrobielle anvendelser - Google Patents
Peptidsekvenser, deres forgrenede form og anvendelse deraf til antimikrobielle anvendelser Download PDFInfo
- Publication number
- DK2344178T3 DK2344178T3 DK09737145.4T DK09737145T DK2344178T3 DK 2344178 T3 DK2344178 T3 DK 2344178T3 DK 09737145 T DK09737145 T DK 09737145T DK 2344178 T3 DK2344178 T3 DK 2344178T3
- Authority
- DK
- Denmark
- Prior art keywords
- peptide
- seq
- map
- peptides
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Claims (17)
1. Antibakterielt peptid, som fra amino- til carboxylterminalen har en aminosy-resekvens udvalgt fra gruppen: KKIRVRLSA, SEQ ID NO. 1, RRIRVRLSA, SEQ ID NO. 2, KRIRVRLSA, SEQ ID NO. 3, RKIRVRLSA, SEQ ID NO. 4.
2. Peptid ifølge krav 1, som har en lineær form.
3. Peptid ifølge krav 2, som er multimeriseret på et skelet af polyacrylamid, på et skelet af dextran-enheder eller på et skelet af ethylenglycol-enheder.
4. Peptid ifølge krav 1, som hårformen Multiple Antigenic Peptides (MAP), med den følgende formel:
i hvilken R er peptidet ifølge krav 1; X er et trifunktionelt molekyle; m=0 eller 1; n=0 eller 1; når m og n er 0, er peptidet en dimer; når m=1 og n=0, er peptidet en tetramer, når m=1 og n=1, er peptidet en octamer.
5. MAP-peptid ifølge krav 4, hvor X er en trifunktionel enhed.
6. MAP-peptid ifølge krav 5, hvor den trifunktionelle enhed omfatter mindst to funktionelle amin-grupper.
7. MAP-peptid ifølge krav 6, hvor X er lysin, ornithin, norlysin eller aminoala-nin.
8. MAP-peptid ifølge krav 4, hvor X er aspartinsyre eller glutaminsyre.
9. MAP-peptid ifølge krav 4, hvor X er propylenglycol, ravsyre, diisocyanater eller diamin-derivat.
10. Peptid ifølge et af de foregående krav til medicinsk anvendelse.
11. Peptid ifølge et af de foregående krav som et antibakterielt medikament.
12. Farmaceutisk sammensætning omfattende en farmaceutisk acceptabel og virksom mængde af peptidet ifølge krav 10 eller 11.
13. Farmaceutisk sammensætning ifølge krav 12, i form afen opløsning, der skal injiceres i individer til systemisk anvendelse.
14. Farmaceutisk sammensætning ifølge krav 12, i form afen opløsning, der skal injiceres som et afgiftningsmiddel til LPS-neutralisering.
15. Farmaceutisk sammensætning ifølge krav 2, i form af et øjenrensemid-del, et mundrensemiddel, en salve eller opløsning til topisk anvendelse.
16. Desinfektions- og/eller rengøringspræparat med antibakteriel aktivitet omfattende peptidet ifølge krav 1 til 11.
17. Anvendelse af peptidet ifølge krav 1 til 11 som et konserveringsmiddel til fremstilling affødevarer og/eller kosmetiske produkter og/eller homøopatiske produkter.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10285408P | 2008-10-05 | 2008-10-05 | |
| PCT/IB2009/054347 WO2010038220A1 (en) | 2008-10-05 | 2009-10-05 | Peptide sequences, their branched form and use thereof for antimicrobial applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2344178T3 true DK2344178T3 (da) | 2015-02-16 |
Family
ID=41723005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09737145.4T DK2344178T3 (da) | 2008-10-05 | 2009-10-05 | Peptidsekvenser, deres forgrenede form og anvendelse deraf til antimikrobielle anvendelser |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8440794B2 (da) |
| EP (1) | EP2344178B1 (da) |
| JP (1) | JP5773271B2 (da) |
| CN (1) | CN102170899A (da) |
| DK (1) | DK2344178T3 (da) |
| ES (1) | ES2530457T3 (da) |
| PL (1) | PL2344178T3 (da) |
| PT (1) | PT2344178E (da) |
| SI (1) | SI2344178T1 (da) |
| WO (1) | WO2010038220A1 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2409579A1 (en) | 2010-07-23 | 2012-01-25 | Setlance S.r.L. | Antimicrobial peptide, branched forms and uses thereof for the cure of bacteria infections |
| ITRM20130565A1 (it) * | 2013-10-14 | 2015-04-15 | Univ Siena | Composti anti tnf-alpha e loro usi |
| US11174288B2 (en) | 2016-12-06 | 2021-11-16 | Northeastern University | Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria |
| EP3354274A1 (en) | 2017-01-25 | 2018-08-01 | SETLANCE S.r.l. | Therapeutic combinations for the treatment of bacterial infections |
| EP3392265A1 (en) | 2017-04-20 | 2018-10-24 | SETLANCE S.r.l. | Methods for removing bacterial toxins from a biological fluid |
| CN108196073B (zh) * | 2018-03-13 | 2019-09-13 | 江苏浩欧博生物医药股份有限公司 | 一种测定抗环瓜氨酸肽抗体的试剂盒及其应用 |
| US10413584B1 (en) * | 2018-08-29 | 2019-09-17 | Riptide Bioscience, Inc. | Peptides having immunomodulatory properties |
| US10548944B1 (en) | 2018-10-19 | 2020-02-04 | Riptide Bioscience, Inc. | Antimicrobial peptides and methods of using the same |
| CA3168643A1 (en) * | 2019-02-28 | 2020-09-03 | Dandi Bioscience Inc. | Polypeptide having antibacterial activity, composition for preventing or treating sepsis comprising same, and antibacterial composition |
| KR102215798B1 (ko) * | 2019-10-31 | 2021-02-15 | 이수경 | 항균 펩타이드를 포함하는 보존제 및 이를 이용한 화장료 조성물 |
| CN114805495B (zh) * | 2022-06-15 | 2023-07-07 | 东北农业大学 | 一种抗酶解分枝状抗菌肽Pal-CRKP及其制备方法和应用 |
| WO2024169972A1 (en) | 2023-02-13 | 2024-08-22 | Enlitisa (Shanghai) Pharmaceutical Co., Ltd. | New multi-functional oligopeptides |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20040349A1 (it) * | 2004-07-13 | 2004-10-13 | Univ Siena | Peptidi antibatterici e loro analoghi. |
| WO2009146885A2 (en) * | 2008-06-02 | 2009-12-10 | Spiderbiotech S.R.L. | Lipidated antibacterial peptides |
-
2009
- 2009-10-05 ES ES09737145T patent/ES2530457T3/es active Active
- 2009-10-05 WO PCT/IB2009/054347 patent/WO2010038220A1/en active Application Filing
- 2009-10-05 US US13/122,426 patent/US8440794B2/en active Active
- 2009-10-05 CN CN2009801390933A patent/CN102170899A/zh active Pending
- 2009-10-05 JP JP2011529671A patent/JP5773271B2/ja active Active
- 2009-10-05 PL PL09737145T patent/PL2344178T3/pl unknown
- 2009-10-05 EP EP09737145.4A patent/EP2344178B1/en active Active
- 2009-10-05 DK DK09737145.4T patent/DK2344178T3/da active
- 2009-10-05 PT PT97371454T patent/PT2344178E/pt unknown
- 2009-10-05 SI SI200931141T patent/SI2344178T1/sl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2344178E (pt) | 2015-02-18 |
| EP2344178B1 (en) | 2014-12-03 |
| EP2344178A1 (en) | 2011-07-20 |
| US20110190198A1 (en) | 2011-08-04 |
| WO2010038220A1 (en) | 2010-04-08 |
| SI2344178T1 (sl) | 2015-04-30 |
| CN102170899A (zh) | 2011-08-31 |
| PL2344178T3 (pl) | 2015-05-29 |
| JP5773271B2 (ja) | 2015-09-02 |
| US8440794B2 (en) | 2013-05-14 |
| ES2530457T3 (es) | 2015-03-03 |
| JP2012504597A (ja) | 2012-02-23 |
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