DK2340872T3 - New pharmaceutical formulations useful in the treatment of insomnia - Google Patents
New pharmaceutical formulations useful in the treatment of insomnia Download PDFInfo
- Publication number
- DK2340872T3 DK2340872T3 DK11002406.4T DK11002406T DK2340872T3 DK 2340872 T3 DK2340872 T3 DK 2340872T3 DK 11002406 T DK11002406 T DK 11002406T DK 2340872 T3 DK2340872 T3 DK 2340872T3
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- DK
- Denmark
- Prior art keywords
- formulation
- approx
- zolpidem
- formulation according
- drug
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- 238000002483 medication Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 230000003232 mucoadhesive effect Effects 0.000 description 1
- 239000003158 myorelaxant agent Substances 0.000 description 1
- 230000001670 myorelaxant effect Effects 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- ARGKVCXINMKCAZ-UZRWAPQLSA-N neohesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@H]3[C@@H]([C@H](O)[C@@H](O)[C@H](C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UZRWAPQLSA-N 0.000 description 1
- ITVGXXMINPYUHD-CUVHLRMHSA-N neohesperidin dihydrochalcone Chemical compound C1=C(O)C(OC)=CC=C1CCC(=O)C(C(=C1)O)=C(O)C=C1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ITVGXXMINPYUHD-CUVHLRMHSA-N 0.000 description 1
- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 description 1
- 238000002414 normal-phase solid-phase extraction Methods 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 229940096978 oral tablet Drugs 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000001915 proofreading effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000011369 resultant mixture Substances 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 230000004620 sleep latency Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 239000008137 solubility enhancer Substances 0.000 description 1
- 238000013516 source data verification Methods 0.000 description 1
- 238000005563 spheronization Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 125000005490 tosylate group Chemical class 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- PHLBKPHSAVXXEF-UHFFFAOYSA-N trazodone Chemical compound ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 PHLBKPHSAVXXEF-UHFFFAOYSA-N 0.000 description 1
- 229960003991 trazodone Drugs 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000001238 wet grinding Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Anesthesiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0423800.2A GB0423800D0 (en) | 2004-10-27 | 2004-10-27 | New pharmaceutical formulations |
| EP05798488.2A EP1807156B1 (en) | 2004-10-27 | 2005-10-26 | New pharmaceutical formulations useful in the treatment of insomnia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2340872T3 true DK2340872T3 (en) | 2017-09-18 |
Family
ID=33515600
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11002406.4T DK2340872T3 (en) | 2004-10-27 | 2005-10-26 | New pharmaceutical formulations useful in the treatment of insomnia |
| DK05798488.2T DK1807156T3 (en) | 2004-10-27 | 2005-10-26 | NEW PHARMACEUTICAL FORMS USED FOR TREATMENT OF SLEEPABILITY |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05798488.2T DK1807156T3 (en) | 2004-10-27 | 2005-10-26 | NEW PHARMACEUTICAL FORMS USED FOR TREATMENT OF SLEEPABILITY |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9265720B2 (https=) |
| EP (2) | EP1807156B1 (https=) |
| JP (1) | JP5064226B2 (https=) |
| CY (2) | CY1118414T1 (https=) |
| DK (2) | DK2340872T3 (https=) |
| ES (1) | ES2610469T3 (https=) |
| GB (1) | GB0423800D0 (https=) |
| HU (1) | HUE030609T2 (https=) |
| LT (2) | LT2340872T (https=) |
| PL (2) | PL2340872T3 (https=) |
| PT (2) | PT1807156T (https=) |
| SI (2) | SI1807156T1 (https=) |
| WO (1) | WO2006046041A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5179757B2 (ja) | 2004-02-17 | 2013-04-10 | トランセプト ファーマシューティカルズ， インコーポレイティド | 口腔粘膜を介して催眠剤をデリバリーするための組成物及びその使用方法 |
| EP1883408A4 (en) * | 2005-05-25 | 2009-11-11 | Transcept Pharmaceuticals Inc | SOLID COMPOSITIONS AND METHODS FOR TREATMENT OF INSOMNIA IN THE NIGHT |
| US20070287740A1 (en) | 2005-05-25 | 2007-12-13 | Transcept Pharmaceuticals, Inc. | Compositions and methods of treating middle-of-the night insomnia |
| WO2008067549A2 (en) * | 2006-11-30 | 2008-06-05 | Transcept Pharmaceuticals, Inc. | Stabilized zolpidem pharmaceutical compositions |
| WO2008075372A1 (en) * | 2006-12-18 | 2008-06-26 | Lupin Limited | Controlled release dosage forms of zolpidem |
| CN101801346A (zh) * | 2007-05-10 | 2010-08-11 | 诺瓦德尔药品公司 | 抗失眠症组合物及方法 |
| TR201808694T4 (tr) * | 2008-06-20 | 2018-07-23 | Merck Patent Gmbh | Doğrudan sıkıştırılabilen ve hızlı parçalanan tablet matrisi. |
| BRPI1012170A2 (pt) * | 2009-05-20 | 2016-03-29 | Lingual Consegna Pty Ltd | formulação e/ou sublingual e método para reduzir a quantidade de composto ativo usado para alcançar um efeito em um paciente em comparação com um composto típico que é ingerido. |
| CN105581991A (zh) * | 2015-12-28 | 2016-05-18 | 安徽省逸欣铭医药科技有限公司 | 一种酒石酸唑吡坦舌下片及其制备方法 |
| SG11202103255RA (en) | 2018-10-08 | 2021-04-29 | Troikaa Pharmaceuticals Ltd | Oromucosal solutions of zolpidem or pharmaceutically acceptable salts thereof |
| CN111939133A (zh) * | 2019-05-16 | 2020-11-17 | 鲁南制药集团股份有限公司 | 一种酒石酸唑吡坦片及其制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK152744C (da) * | 1982-08-13 | 1988-10-31 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat |
| SE8800080L (sv) | 1988-01-13 | 1989-07-14 | Kabivitrum Ab | Laekemedelskomposition |
| SE8803935L (sv) | 1988-10-31 | 1990-05-01 | Kabivitrum Ab | Laekemedelskomposition |
| JPH0665103A (ja) * | 1992-08-13 | 1994-03-08 | ▲寛▼治 ▲高▼田 | 向精神薬のための速吸収性舌下投与製剤 |
| US7632517B2 (en) | 1997-10-01 | 2009-12-15 | Novadel Pharma Inc. | Buccal, polar and non-polar spray containing zolpidem |
| US6200604B1 (en) | 1998-03-27 | 2001-03-13 | Cima Labs Inc. | Sublingual buccal effervescent |
| SE9803240D0 (sv) * | 1998-09-24 | 1998-09-24 | Diabact Ab | A pharmaceutical composition having a rapid action |
| SE9803239D0 (sv) * | 1998-09-24 | 1998-09-24 | Diabact Ab | Composition for the treatment of acute pain |
| EP1005863A1 (en) * | 1998-12-04 | 2000-06-07 | Synthelabo | Controlled-release dosage forms comprising a short acting hypnotic or a salt thereof |
| AU7937500A (en) * | 1999-10-27 | 2001-05-08 | Farmarc Nederland Bv | Pharmaceutical composition containing midazolam |
| AU5066101A (en) * | 2000-04-13 | 2001-10-30 | Synthon B.V. | Modified release formulations containing a hypnotic agent |
| CN1290525A (zh) | 2000-10-10 | 2001-04-11 | 北京万全阳光医药科技有限公司 | 冷冻干燥的扎来普隆速溶口服组合物 |
| US20040176359A1 (en) | 2001-02-20 | 2004-09-09 | University Of Kentucky Research Foundation | Intranasal Benzodiazepine compositions |
| US20030035839A1 (en) * | 2001-05-15 | 2003-02-20 | Peirce Management, Llc | Pharmaceutical composition for both intraoral and oral administration |
| AU2002259241B2 (en) * | 2001-05-24 | 2008-09-04 | Alexza Pharmaceuticals, Inc. | Delivery of sedative-hypnotics through an inhalation route |
| ES2301797T3 (es) * | 2002-01-10 | 2008-07-01 | Biovail Laboratories International Srl | Formulaciones sedantes no benzodiazepinicas. |
| JP4551092B2 (ja) | 2002-03-06 | 2010-09-22 | 協和発酵キリン株式会社 | 口腔内速崩壊性錠剤 |
| US20050208127A1 (en) | 2002-06-10 | 2005-09-22 | Kazuyoshi Ogasawara | Rapidly disintegrating tablet and process for producing the same |
| ES2199061B1 (es) | 2002-06-10 | 2005-02-16 | Laboratorios Vita, S.A. | Comprimidos bucodispersables y procedimiento para su obtencion. |
| US20050038042A1 (en) * | 2002-11-15 | 2005-02-17 | Jenet Codd | Modified release composition comprising a short-acting hypnotic for treatment of sleep disorders |
| CN1418631A (zh) | 2002-12-19 | 2003-05-21 | 王登之 | 治疗失眠的佐匹克隆口腔崩解片及其制备方法 |
| US20040265375A1 (en) | 2003-04-16 | 2004-12-30 | Platteeuw Johannes J. | Orally disintegrating tablets |
| WO2004100857A2 (en) * | 2003-05-07 | 2004-11-25 | Akina, Inc. | Highly plastic granules for making fast melting tablets |
| WO2005063248A1 (en) * | 2003-12-22 | 2005-07-14 | Sepracor Inc. | Modafinil combination therapy for improving sleep quality |
| NZ548856A (en) | 2004-02-17 | 2009-10-30 | Transcept Pharmaceuticals Inc | Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof |
| JP5179757B2 (ja) * | 2004-02-17 | 2013-04-10 | トランセプト ファーマシューティカルズ， インコーポレイティド | 口腔粘膜を介して催眠剤をデリバリーするための組成物及びその使用方法 |
| CN1290525C (zh) * | 2004-07-13 | 2006-12-20 | 赵余庆 | 一种降血糖的植物提取物及其用途 |
-
2004
- 2004-10-27 GB GBGB0423800.2A patent/GB0423800D0/en not_active Ceased
-
2005
- 2005-10-26 HU HUE05798488A patent/HUE030609T2/en unknown
- 2005-10-26 DK DK11002406.4T patent/DK2340872T3/en active
- 2005-10-26 PT PT57984882T patent/PT1807156T/pt unknown
- 2005-10-26 LT LTEP11002406.4T patent/LT2340872T/lt unknown
- 2005-10-26 EP EP05798488.2A patent/EP1807156B1/en not_active Expired - Lifetime
- 2005-10-26 PT PT110024064T patent/PT2340872T/pt unknown
- 2005-10-26 PL PL11002406T patent/PL2340872T3/pl unknown
- 2005-10-26 EP EP11002406.4A patent/EP2340872B1/en not_active Expired - Lifetime
- 2005-10-26 ES ES05798488.2T patent/ES2610469T3/es not_active Expired - Lifetime
- 2005-10-26 SI SI200532117A patent/SI1807156T1/sl unknown
- 2005-10-26 SI SI200532171T patent/SI2340872T1/sl unknown
- 2005-10-26 LT LTEP05798488.2T patent/LT1807156T/lt unknown
- 2005-10-26 US US11/666,361 patent/US9265720B2/en active Active
- 2005-10-26 WO PCT/GB2005/004147 patent/WO2006046041A1/en not_active Ceased
- 2005-10-26 DK DK05798488.2T patent/DK1807156T3/en active
- 2005-10-26 PL PL05798488T patent/PL1807156T3/pl unknown
- 2005-10-26 JP JP2007538505A patent/JP5064226B2/ja not_active Expired - Lifetime
-
2011
- 2011-07-15 US US13/184,016 patent/US20110268796A1/en not_active Abandoned
-
2012
- 2012-02-22 US US13/402,580 patent/US20120277261A1/en not_active Abandoned
-
2013
- 2013-04-25 US US13/870,737 patent/US9597281B2/en active Active
-
2017
- 2017-01-11 CY CY20171100038T patent/CY1118414T1/el unknown
- 2017-09-26 CY CY20171101007T patent/CY1119580T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20080311208A1 (en) | 2008-12-18 |
| CY1119580T1 (el) | 2018-03-07 |
| GB0423800D0 (en) | 2004-12-01 |
| ES2610469T3 (es) | 2017-04-27 |
| PT1807156T (pt) | 2017-01-19 |
| US20110268796A1 (en) | 2011-11-03 |
| EP2340872A1 (en) | 2011-07-06 |
| HUE030609T2 (en) | 2017-05-29 |
| EP1807156B1 (en) | 2016-10-12 |
| LT1807156T (lt) | 2016-12-12 |
| LT2340872T (lt) | 2017-09-11 |
| US20130230589A1 (en) | 2013-09-05 |
| US9597281B2 (en) | 2017-03-21 |
| PL2340872T3 (pl) | 2017-12-29 |
| SI2340872T1 (sl) | 2017-10-30 |
| JP2008517988A (ja) | 2008-05-29 |
| CY1118414T1 (el) | 2017-06-28 |
| JP5064226B2 (ja) | 2012-10-31 |
| US9265720B2 (en) | 2016-02-23 |
| WO2006046041A1 (en) | 2006-05-04 |
| PL1807156T3 (pl) | 2017-06-30 |
| SI1807156T1 (sl) | 2017-01-31 |
| EP2340872B1 (en) | 2017-07-05 |
| PT2340872T (pt) | 2017-10-06 |
| EP1807156A1 (en) | 2007-07-18 |
| US20120277261A1 (en) | 2012-11-01 |
| DK1807156T3 (en) | 2017-01-23 |
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