DK2334326T3 - Mimotoper af alfa-synuklein og vacciner deraf til behandlingen af neurodegenerative forstyrrelser - Google Patents

Mimotoper af alfa-synuklein og vacciner deraf til behandlingen af neurodegenerative forstyrrelser Download PDF

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DK2334326T3
DK2334326T3 DK09712380.6T DK09712380T DK2334326T3 DK 2334326 T3 DK2334326 T3 DK 2334326T3 DK 09712380 T DK09712380 T DK 09712380T DK 2334326 T3 DK2334326 T3 DK 2334326T3
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peptide
synuclein
alpha
compound
artificial
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DK09712380.6T
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Markus Mandler
Harald Weninger
Radmila Santic
Edith Kopinits
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Affiris Ag
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Claims (11)

1. Mindst én forbindelse omfattende et peptid der har aminosyresekvensen valgt fra gruppen bestående af CDQPVLPD, CDMPVLPD, CDSPVLPD, CDQPVLPDN, CDMPVLPDN, CDSPVLPDN, CHDRPVTPD, CDRPVTPD, CDVPVLPD, CDTPVYPD, CDTPVIPD, CHDRPVTPDN, CDRPVTPDN, CDVPVLPDN, CDTPVYPDN, CDQPVLPDG, CDMPVLPDG, CDSPVLPDG, CDHPVHPDS, CDMPVSPDR, CDRPVYPDI, CDHPVTPDR, CDTPVLPDS, CDMPVTPDT, CDAPVTPDT, CDSPVVPDN, CDLPVTPDR, CDSPVHPDT, CDAPVRPDS, CDMPVWPDG, CDRPVQPDR, CYDRPVQPDR, CDMPVDADN, DQPVLPDC og DMPVLPDC, til anvendelse til forebyggelse og/eller behandling af synukleinopatier.
2. Forbindelse til anvendelse ifølge krav 1, kendetegnet ved at peptidet omfatter ved dets N- og/eller C-terminus en acetyleret aminosyrerest eller cystein (C).
3. Forbindelse til anvendelse ifølge krav 1 eller 2, kendetegnet ved at synukleinopatien er valgt fra gruppen bestående af Lewy Body-forstyrrelser (LBDs), fortrinsvis Parkinson's sygdom (PD), Parkison's sygdom med demens (PDD) og demens med Lewy Bodies (DLB), såvel som multipel system atrofi (MSA) eller neurodegeneration med hjerne jern akkumulation type I (NBIAType I)·
4. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1 til 3, kendetegnet ved at forbindelsen er koblet til en farmaceutisk acceptabel bærer, fortrinsvis KLH (Keyhole Limpet Hemocyanin).
5. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1 til 4, kendetegnet ved at forbindelsen er formuleret til intravenøs, subkutan, intradermal eller intramuskulær administration.
6. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1 til 5, kendetegnet ved at forbindelsen er formuleret med en adjuvans, fortrinsvis aluminiumhydroxid.
7. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 1 til 6, kendetegnet ved at forbindelsen er indeholdt i medikamentet i en mængde på fra 0,1 ng til 10 mg, fortrinsvis 10 ng til 1 mg, især 100 ng til 100 pg.
8. Peptid med en aminosyresekvens valgt fra gruppen bestående af CDQPVLPD, CDMPVLPD, CDSPVLPD, CDQPVLPDN, CDMPVLPDN, CDSPVLPDN, CHDRPVTPD, CDRPVTPD, CDVPVLPD, CDTPVYPD, CDTPVIPD, CHDRPVTPDN, CDRPVTPDN, CDVPVLPDN, CDTPVYPDN, CDQPVLPDG, CDMPVLPDG, CDSPVLPDG, CDHPVHPDS, CDMPVSPDR, CDRPVYPDI, CDHPVTPDR, CDTPVLPDS, CDMPVTPDT, CDAPVTPDT, CDSPVVPDN, CDLPVTPDR, CDSPVHPDT, CDAPVRPDS, CDMPVWPDG, CDRPVQPDR, CYDRPVQPDR, CDMPVDADN, DQPVLPDC, og DMPVLPDC.
9. Peptid ifølge krav 8, kendetegnet ved at peptidet er koblet til en farmaceutisk acceptabel bærer, fortrinsvis KLH (Keyhole Limpet Hemocyanin).
10. Farmaceutisk formulering omfattende mindst ét peptid ifølge krav 8 eller 9.
11. Farmaceutisk formulering ifølge krav 10 til anvendelse som en vaccine.
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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007120834A2 (en) 2006-04-13 2007-10-25 Peptimmune, Inc. Methods for designing and synthesizing directed sequence polymer compositions via the directed expansion of epitope permeability
EP2586460A1 (en) 2007-10-16 2013-05-01 Peptimmune, Inc. Method for designing and preparing vaccines comprising directed sequence polymer composition via the directed expansion of epitopes
AT506535B1 (de) 2008-02-22 2010-04-15 Affiris Forschungs & Entwicklungs Gmbh Vaccine enthaltend alpha-synuclein-mimotope auf basis von peptiden
US8546532B2 (en) 2008-04-17 2013-10-01 Declion Pharmaceuticals, Inc. Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
US8940276B2 (en) 2008-12-19 2015-01-27 Biogen Idec International Neuroscience Gmbh Human anti-alpha-synuclein antibodies
PT2723379T (pt) * 2011-06-23 2018-11-14 Univ Of Zuerich Moléculas de ligação anti-alfa-sinucleína
SI2579042T1 (sl) 2011-10-04 2014-09-30 Affiris Ag Postopek za detektiranje Ass-specifičnih protiteles v biološkem vzorcu
CA2863953A1 (en) * 2012-01-27 2013-08-01 Neotope Biosciences Limited Humanized antibodies that recognize alpha-synuclein
EP2659906A1 (en) 2012-05-01 2013-11-06 Affiris AG Compositions
EP2659907A1 (en) * 2012-05-01 2013-11-06 Affiris AG Compositions
CN111499742B (zh) * 2013-11-21 2024-05-07 豪夫迈·罗氏有限公司 抗-α-突触核蛋白抗体及使用方法
WO2016005545A1 (en) * 2014-07-10 2016-01-14 Affiris Ag Substances and methods for the use in prevention and/or treatment in huntington's disease
JP6684524B2 (ja) * 2015-03-09 2020-04-22 イミューン モジュレーション，インク． 神経変性疾患の処置または予防のためのハイポエストキシド、その誘導体、関連化合物、およびアゴニスト
AU2016348610B2 (en) * 2015-11-03 2023-08-31 Ac Immune Sa Method for vaccination against a self-antigen in a human patient
WO2018005867A2 (en) * 2016-06-29 2018-01-04 The Regents Of The University Of California Structure-based peptide inhibitors of alpha-synuclein aggregation
TWI644673B (zh) * 2017-07-27 2018-12-21 百朗克股份有限公司 頭孢曲松的用途
IL300364A (en) 2020-08-04 2023-04-01 Ac Immune Sa immunogenic substances
EP4357354A1 (en) 2021-06-18 2024-04-24 Sumitomo Pharma Co., Ltd. Epitope peptide of human alpha-synuclein and pharmaceutical composition including said peptide
WO2023152260A1 (en) 2022-02-09 2023-08-17 Ac Immune Sa Anti-alpha-synuclein therapeutic vaccines
WO2023161526A1 (en) 2022-02-28 2023-08-31 Tridem Bioscience Gmbh & Co Kg A CONJUGATE CONSISTING OF OR COMPRISING AT LEAST A ß-GLUCAN OR A MANNAN
WO2023161527A1 (en) 2022-02-28 2023-08-31 Tridem Bioscience Gmbh & Co Kg A CONJUGATE CONSISTING OF OR COMPRISING AT LEAST A ß-GLUCAN OR A MANNAN
AT525943A2 (de) * 2022-02-28 2023-09-15 Tridem Bioscience Gmbh & Co Kg Konjugat bestehend aus oder umfassend zumindest ein ß-Glucan oder ein Mannan

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030170229A1 (en) * 1999-02-25 2003-09-11 Smithkline Beecham Biologicals S.A. Vaccine
US7834146B2 (en) * 2000-05-08 2010-11-16 Monsanto Technology Llc Recombinant polypeptides associated with plants
US8106174B2 (en) * 2000-05-08 2012-01-31 Monsanto Technology Llc Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
WO2002094867A2 (fr) * 2001-02-07 2002-11-28 Institut Pasteur Sequence du genome de photorhabdus luminescens souche tto1 et utilisations
JP4863341B2 (ja) * 2001-09-06 2012-01-25 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 ヒラメラブドウイルス感染魚類用ｄｎａワクチン
WO2003045128A2 (en) 2001-11-21 2003-06-05 New York University SYNTHETIC IMMUNOGENIC BUT NON-DEPOSIT-FORMING POLYPEPTIDES AND PEPTIDES HOMOLOGOUS TO AMYLOID β, PRION PROTEIN, AMYLIN, α-SYNUCLEIN, OR POLYGLUTAMINE REPEATS FOR INDUCTION OF AN IMMUNE RESPONSE THERETO
GB0216972D0 (en) * 2002-07-22 2002-08-28 Univ Lancaster Peptides and peptide derivaties for the treatment of &-synuclein-related diseases
US9034337B2 (en) * 2003-10-31 2015-05-19 Prothena Biosciences Limited Treatment and delay of outset of synucleinopathic and amyloidogenic disease
US8506959B2 (en) * 2002-11-01 2013-08-13 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
TW200509968A (en) * 2002-11-01 2005-03-16 Elan Pharm Inc Prevention and treatment of synucleinopathic disease
US20080014194A1 (en) * 2003-10-31 2008-01-17 Elan Pharmaceuticals, Inc. Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease
US7521481B2 (en) * 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
WO2004089369A2 (en) * 2003-04-11 2004-10-21 Cambridge University Technical Services Limited Methods and means for treating protein conformational disorders
US7358331B2 (en) * 2003-05-19 2008-04-15 Elan Pharmaceuticals, Inc. Truncated fragments of alpha-synuclein in Lewy body disease
EP2361928B1 (en) 2003-05-19 2017-04-26 Prothena Biosciences Limited Truncated fragments of alpha-synuclein in Lewy body disease
US20070213253A1 (en) 2003-06-22 2007-09-13 Koji Sode Synuclein Mutant Having Aggregation-Inhibitory Activity
EP2186518A1 (en) * 2004-11-17 2010-05-19 McLaurin, Joanne Composition and methods for treatment of disorders of protein aggregation
CN101142482A (zh) * 2005-02-25 2008-03-12 阿拉巴马大学董事会 蛋白错误折叠和聚集的调节因子及其使用方法
CA2598792A1 (en) * 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
CA2607651A1 (en) * 2005-05-18 2007-04-19 Maxygen, Inc. Evolved interferon-alpha polypeptides
JP2009523815A (ja) * 2006-01-19 2009-06-25 アンブルックス，インコーポレイテッド 免疫原性が調節された非天然アミノ酸ポリペプチド
WO2007129221A2 (en) * 2006-02-17 2007-11-15 Waratah Parmaceuticals Inc Compositions comprising an epi-inositol compounds and methods for treatment of disorders of protein aggregation
US20070197452A1 (en) * 2006-02-17 2007-08-23 Mclaurin Joanne Treatment of amyloid-related diseases
JP2010510254A (ja) * 2006-11-24 2010-04-02 ワラタ ファーマシューティカルズ， インコーポレイテッド アルツハイマー病および関連の神経変性疾患のための併用処置
US20120142902A1 (en) * 2007-02-23 2012-06-07 The Regents Of The University Of California Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease
US8147833B2 (en) * 2007-02-23 2012-04-03 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
DK3067066T3 (da) * 2007-02-23 2019-05-20 Prothena Biosciences Ltd Forebyggelse og behandling af synukleinopatisk og amyloidogenisk sygdom
AT505574B1 (de) * 2007-08-10 2009-09-15 Affiris Forschungs & Entwicklungs Gmbh Mimotope zur behandlung von atherosklerose
AT506535B1 (de) * 2008-02-22 2010-04-15 Affiris Forschungs & Entwicklungs Gmbh Vaccine enthaltend alpha-synuclein-mimotope auf basis von peptiden
US8343497B2 (en) * 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics

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