WO2002094867A2 - Sequence du genome de photorhabdus luminescens souche tto1 et utilisations - Google Patents

Abstract

L'invention a pour objet la séquence génomique et des séquences nucléotidiques codant pour des polypeptides de Photorhabdus luminescens, tels que des polypeptides impliqués dans des opérons de biosynthèse d'antibiotiques, ou de toxines, ou des polypeptides à activité de type toxine ou antibiotique pouvant être utilisés comme pesticide, bactéricide ou fongicide ainsi que des vecteurs incluant lesdites séquences et des cellules ou animaux transformés par ces vecteurs.

Description

SEQUENCE DU GENOME DE PHOTORHABDUS LUMINESCENS SOUCHE TT01 ET UTILISATIONS

L'invention a pour objet la séquence génomique et des séquences nucléotidiques codant pour des polypeptides de Photorhabdus luminescens, tels que des polypeptides impliqués dans des opérons de biosynthèse d'antibiotiques, ou de toxines, ou des polypeptides à activité de type toxine ou antibiotique pouvant être utilisés comme pesticide, bactéricide ou fongicide ainsi que des vecteurs incluant lesdites séquences et des cellules ou animaux transformés par ces vecteurs. Photorhabdus luminescens est une bactérie entomopathogène, commensale intestinal d'un nematode et parasite d'insecte. Cette bactérie est à la fois un modèle pour l'étude des interactions hôte-parasite et une bactérie dont les applications industrielles sont nombreuses en raison de sa capacité à synthétiser de nombreuses toxines (insecticides, bactéricides et fongicides) et à sécréter de nombreuses enzymes. Afin d'appréhender de manière globale les déterminants génétiques impliqués dans ces processus, le séquençage du génome Photorhabdus luminescens a été réalisé.

Le choix de la souche TT01 Photorhabdus luminescens, sous-espèce laumondii dont le séquençage du génome a été réalisé dans la présente invention, est très important car cette souche présente plusieurs avantages : - son génome est stable ;

- elle peut être cultivée sur boîte de Pétri ;

- elle est centrale dans l'arbre phylogénétique, donc représentative de l'espèce ; et

- son nematode associé est connu et cultivé (Heterorhabditis bacteriophora HP88, Trinidad).

La présente invention concerne ainsi les séquences nucléotidiques et polypeptidiques de Photorhabdus luminescens souche TT01.

Ainsi, c'est un objet de la présente invention que de divulguer la séquence du génome de Photorhabdus luminescens, souche TT01 contenue dans la banque génomique préparée à partir du génome de cette souche et déposée à la CNCM le 12 mai 2000 sous le numéro 1-2478 ainsi que de tous les gènes et séquences régulatrices non codantes contenus dans ledit génome.

La souche Photorhabdus luminescens TT01 est également identifiée dans la présente demande par Photorhabdus luminescens, de manière interchangeable. L'invention concerne également de nouveaux outils pour le typage des souches de Photorhabdus. Ces outils pourraient être du type "puce" à ADN ou d'un autre type. Les caractéristiques nouvelles de ces outils de typage seront les suivantes :

* rapidité et simplicité d'utilisation ; * haut pouvoir de discrimination entre les souches ; et

* possibilité de fournir des informations sur le contenu génomique de la souche analysée.

La présente invention concerne donc une séquence nucléotidique isolée issue du génome de Photorhabdus luminescens, caractérisée en ce qu'elle comprend une séquence choisie parmi les séquences SEQ ID N° 1 à SEQ ID N° 41 et les séquences SEQ ID N° 5826 à SEQ ID N° 5834.

Les séquences SEQ ID N° 1 à SEQ ID N° 41 représentent les séquences de 41 contigs dont l'ensemble recouvre la séquence génomique de Photorhabdus luminescens TTOl. Ces séquences SEQ ïï) N° 1 à SEQ ID N° 41 ont pu être réassemblées et relissées en 9 nouvaux contigs dont l'ensemble recouvre également la séquence génomique de Photorhabdus luminescens TTOl. Les séquences SEQ ID N° 5826 à SEQ ID N° 5834 représentent les séquences de ces 9 contigs

Les séquences nucléotidiques SEQ ID N° 1 à SEQ ID N° 41 et SEQ ID N° 5826 à SEQ ID N° 5834 ont été obtenues par séquençage du génome de Photorhabdus luminescens TTOl par la technique dite de shot-gun (cf. Exemples). Malgré la grande précision de ces séquences SEQ ïï) N° 1 à SEQ ïï) N° 41 ou SEQ ïï) N° 5826 à SEQ ïï) N° 5834, il est possible que celles-ci ne représentent pas de manière parfaite à 100 % après assemblage la séquence nucléotidique du génome de Photorhabdus luminescens TTOl et que quelques rares erreurs de séquençage ou indéterminations subsistent dans ces séquences. Dans la présente invention, la présence d'une indétermination d'un acide aminé est désignée par « Xaa » et celle d'un nucleotide est désignée par « N » ou « n » dans la liste des séquences ci-après. Ces quelques rares erreurs ou indéterminations pourraient facilement être mises en évidence et corrigées par l'homme de l'art à partir du chromosome entier et/ou de ses fragments représentatifs selon l'invention et des méthodes standards d'amplification, de clonage et de séquençage, les séquences obtenues pouvant facilement être comparées, en particulier au moyen d'un logiciel informatique et en utilisant des supports d'enregistrement des séquences selon l'invention lisibles par un ordinateur tels que décrits par exemple ci-après. Après correction de ces éventuelles rares erreurs ou indéterminations, la séquence nucléotidique corrigée obtenue comporterait encore au moins 97 %, de préférence au moins 98 %, 98,5 %, 99 % ou 99,9 % d'identité avec la séquence génomique obtenue après assemblage de ces séquences nucléotidiques SEQ ïï) N° 1 à SEQ ïï) N° 41 ou SEQ ïï) N° 5826 à SEQ ïï) N° 5834.

La présente invention concerne également une séquence nucléotidique isolée issue du génome Photorhabdus luminescens, caractérisée en ce qu'elle est choisie parmi : a) une séquence nucléotidique comportant au moins 75 %, 80 %, 85 %, 90 %, 95 %, 98 % ou 99 % d'identité avec une séquence choisie parmi les séquences SEQ ïï)

N° 1 à SEQ ïï) N° 41 ou SEQ ïï) N° 5826 à SEQ ï) N° 5834 ; b) une séquence nucléotidique comprenant un fragment représentatif d'une séquence choisie parmi les séquences SEQ ïï) N° 1 à SEQ ïï) N° 41 ou SEQ ïï) N° 5826 à SEQ ÏÏ) N° 5834 ; c) une séquence nucléotidique complémentaire d'une séquence nucléotidique telle que définie en a) ou b) ; d) une séquence nucléotidique de l'ARN correspondant à l'une des séquences telles que définies en a), b) ou c) ; e) une séquence nucléotidique telle que définie en a), b), c) ou d) modifiée ; f) une séquence nucléotidique hybridant dans des conditions de forte stringence avec une séquence choisie parmi SEQ ïï) N° 1 à SEQ ïï) N° 41 ou SEQ ïï) N° 5826 à SEQ ï) N° 5834, et comportant au moins 20 nucléotides, de préférence au moins 25, 30, 50, 75, 100, 150, 200, 250, 500, 750, 1000, 1500, 2000 ou 2500 nucléotides. De façon plus particulière, la présente invention a également pour objet une séquence nucléotidique comprise dans une des séquences SEQ ïï) N° 1 à SEQ ïï) N° 41 ou une des séquences SEQ ïï) N° 5826 à SEQ ïï) N° 5834, et en ce qu'elle code pour un polypeptide choisi parmi les polypeptides de séquence SEQ ï) N° 42 à SEQ ïï) N° 3855 ou parmi les polypeptides codés par une séquence SEQ ïï) N° 5835 à SEQ ïï) N° 10784 . De préférence les polypeptides codés par une des séquence SEQ ï) N° 5835 à

SEQ ïï) N° 10784, sont les polypeptides dont la séquence d'au moins 5 acides aminés est obtenue en prenant comme cadre de lecture le premier nucleotide des séquences SEQ ïï) N° 5835 à SEQ ïï) N° 10784. De manière très préférée, l'invention a également pour objet une séquence nucléotidique, caractérisée en ce qu'elle code pour un polypeptide dont la fonction annotée au tableau I ci-après, dernière colonne ou au tableau ïï ci-après, avant-dernière colonne, correspond à une activité de type toxine et/ou antibiotique, ou à un opéron impliqué dans la synthèse de toxine et/ou d'antibiotique, polypeptide choisi de préférence parmi : a) les polypeptides de séquences SEQ ïï) N° 61, SEQ ïï) N° 62, SEQ ïï) N° 67, SEQ ïï) N° 171, SEQ ïï) N° 221, SEQ ïï) N° 268, SEQ ïï) N° 288, SEQ ïï) N° 380, SEQ ïï) N° 426, SEQ ïï) N° 438, SEQ ïï) N° 448, SEQ ïï) N° 453, SEQ ïï) N° 455, SEQ ïï) N° 456, SEQ ïï) N° 458, SEQ ïï) N° 501, SEQ ïï⁾ N° 516, SEQ ï) N° 530, SEQ ïï) N° 542, SEQ ïï) N° 551, SEQ ïï) N° 720, SEQ ïï) N° 761, SEQ ïï) N° 762, SEQ ïï) N° 814, SEQ ïï) N° 859, SEQ ï) N° 860, SEQ ïï) N° 861, SEQ ïï) N° 862, SEQ ï) N° 869, SEQ ïï) N° 1079, SEQ ïï) N° 1168, SEQ ÏÏ) N° 1174, SEQ ïï) N° 1176, SEQ ïï) N° 1413, SEQ ïï) N° 1414, SEQ ïï) N° 1415, SEQ ïï) N° 1416, SEQ ïï) N° 1417, SEQ ïï) N° 1457, SEQ ïï) N° 1651, SEQ ïï) N° 1856, SEQ ïï) N° 1869, SEQ ïï) N° 2021, SEQ ïï) N° 2080, SEQ ïï) N° 2152, SEQ ïï) N° 2162, SEQ ïï) N° 2173, SEQ ïï) N° 2251, SEQ ïï) N° 2295, SEQ ïï) N° 2306, SEQ ïï) N° 2317, SEQ ïï) N° 2328, SEQ ï) N° 2340, SEQ ïï) N° 2342, SEQ ïï) N° 2351, SEQ ïï) N° 2500, SEQ ïï) N° 3228, SEQ ï) N° 3230, SEQ ïï) N° 3311, SEQ ïï) N° 3317, SEQ ïï) N° 3318, SEQ ïï) N° 3319, SEQ ïï) N° 3320, SEQ ïï) N° 3322, SEQ ï⁾ N° 3323, SEQ ïï) N° 3326, SEQ ï) N° 3327, SEQ ïï) N° 3328, SEQ ïï) N° 3375, SEQ ïï) N° 3376, SEQ ïï) N° 3377, SEQ ïï) N° 3378, SEQ ïï) N° 3422, SEQ ïï) N° 3489, SEQ ïï) N° 3503, SEQ ïï) N° 3609, SEQ ï) N° 3623, SEQ ïï) N° 3624, SEQ ïï) N° 3772, SEQ ïï) N° 3783, SEQ ïï) N° 3788 et SEQ ïï) N° 3794 ; ou b) parmi les polypeptidiques codées par les séquences SEQ ïï) N° 5835 à SEQ ïï) N° 10784 homologues aux séquences telles que définies en a) ci-avant, comme indiqué à la dernière colonne du tableau ïï.

Ces 82 polypeptides de séquence telle que défini dans le paragraphe a) ci-avant dont la fonction est associée à une activité de type toxine ou antibiotique, ou leur polypeptide homologue du tableau ïï tel que défini dans le paragraphe b) ci-avant, ont pu être identifiés, par exemple, par la présence d'un motif concensus liée à ces fonctions ou par la présence de séquences les jouxtant sur le génome et impliquées dans ce type d'activité. La présente invention concerne aussi de façon plus générale les séquences nucléotidiques issues de SEQ ïï) N° 1 à SEQ ïï) N° 41 ou SEQ ïï) N° 5826 à SEQ ïï)

N° 5834, et codant pour un polypeptide de P. luminescens, telles qu'elles peuvent être isolées à partir de SEQ ïï) N° 1 à SEQ ïï) N° 41 ou SEQ ïï) N° 5826 à SEQ ïï) N° 5834.

De plus, les séquences nucléotidiques caractérisées en ce qu'elles comprennent une séquence nucléotidique choisie parmi : a) une séquence nucléotidique codant pour un polypeptide choisi parmi les séquences SEQ ïï) N° 42 à SEQ ïï) N° 3855 ou parmi les polypeptides codés par les séquences SEQ ïï) N° 5835 à SEQ ïï) N° 10784, de préférence parmi les 82 séquences de polypeptides ci-avant sélectionnés pour leur fonction associée à une activité de type toxine ou antibiotique ou leur peptide homologue tel que défini dans le tableau ïï à la dernière colonne ; b) une séquence nucléotidique comportant au moins 75 % d'identité avec une séquence nucléotidique telle que définie en a), de préférence d'au moins 80 %, 85 %,

90 %, 95 %, 98 % ou 99 % d'identité ; c) une séquence nucléotidique complémentaire ou d'ARN correspondant à une séquence telle que définie en a) ou b) ; d) une séquence nucléotidique d'un fragment représentatif d'une séquence telle que définie en a) ou c) ; et e) une séquence telle que définie en a), ou c) modifiée, sont également des objets de l'invention.

Par acide nucléique, séquence nucléique ou d'acide nucléique, polynucléotide, ohgonucleotide, séquence de polynucléotide, séquence nucléotidique, termes qui seront employés indifféremment dans la présente description, on entend désigner un enchaînement précis de nucléotides, modifiés ou non, permettant de définir un fragment ou une région d'un acide nucléique, comportant ou non des nucléotides non naturels, et pouvant correspondre aussi bien à un ADN double brin, un ADN simple brin qu'à des produits de transcription desdits ADNs. Ainsi, les séquences nucléiques selon l'invention englobent également les PNA (Peptid Nucleic Acid).

Il doit être compris que la présente invention ne concerne pas les séquences nucléotidiques dans leur environnement chromosomique naturel, c'est-à-dire à l'état naturel. Il s'agit de séquences qui ont été isolées et/ou purifiées, c'est-à-dire qu'elles ont été prélevées directement ou indirectement, par exemple par copie, leur environnement ayant été au moins partiellement modifié. On entend ainsi également désigner les acides nucléiques obtenus par synthèse chimique.

Par « pourcentage d'identité » entre deux séquences d'acides nucléiques ou d'acides aminés au sens de la présente invention, on entend désigner un pourcentage de nucléotides ou de résidus d'acides aminés identiques entre les deux séquences à comparer, obtenu après le meilleur alignement, ce pourcentage étant purement statistique et les différences entre les deux séquences étant réparties au hasard et sur toute leur longueur. On entend désigner par "meilleur alignement" ou "alignement optimal", l'alignement pour lequel le pourcentage d'identité déterminé comme ci-après est le plus élevé. Les comparaisons de séquences entre deux séquences d'acides nucléiques ou d'acides aminés sont traditionnellement réalisées en comparant ces séquences après les avoir alignées de manière optimale, ladite comparaison étant réalisée par segment ou par « fenêtre de comparaison » pour identifier et comparer les régions locales de similarité de séquence. L'alignement optimal des séquences pour la comparaison peut être réalisé, outre manuellement, au moyen de l'algorithme d'homologie locale de Smith et Waterman (1981, Ad. App. Math., 2:482), au moyen de l'algorithme d'homologie locale de Neddleman et Wunsch (1970, J. Mol. Biol., 48:443), au moyen de la méthode de recherche de similarité de Pearson et Lipman (1988, Proc. Natl. Acad. Sci. USA, 85:2444), au moyen de logiciels informatiques utilisant ces algorithmes (GAP, BESTFIT, BLAST P, BLAST N, FASTA et TFASTA dans le Wisconsin Genetics Software Package, Genetics Computer Group, 575 Science Dr., Madison, WI). Afin d'obtenir l'alignement optimal, on utilise de préférence le programme BLAST, avec la matrice BLOSUM 62. On peut également utiliser les matrices PAM ou PAM250.

Le pourcentage d'identité entre deux séquences d'acides nucléiques ou d'acides aminés est déterminé en comparant ces deux séquences alignées de manière optimale, la séquence d'acides nucléiques ou d'acides aminés à comparer pouvant comprendre des additions ou des délétions par rapport à la séquence de référence pour un alignement optimal entre ces deux séquences. Le pourcentage d'identité est calculé en déterminant le nombre de positions identiques pour lesquelles le nucleotide ou le résidu d'acide aminé est identique dans les deux séquences, en divisant ce nombre de positions identiques par le nombre total de positions comparées et en multipliant le résultat obtenu par 100 pour obtenir le pourcentage d'identité entre ces deux séquences. Par séquences nucléiques présentant un pourcentage d'identité d'au moins 75 %, de préférence 80 %, 85 %, 90 %, 95 %, 98 % ou 99 %, après alignement optimal avec une séquence de référence, on entend désigner les séquences nucléiques présentant, par rapport à la séquence nucléique de référence, certaines modifications comme en particulier une délétion, une troncation, un allongement, une fusion chimérique et/ou une substitution, notamment ponctuelle, et dont la séquence nucléique présente au moins 75 %, de préférence 80 %, 85 %, 90 %, 95 %, 98 % ou 99 %, d'identité après alignement optimal avec la séquence nucléique de référence. Il s'agit de préférence de séquences dont les séquences complémentaires sont susceptibles de s'hybrider spécifiquement avec les séquences de référence. De préférence, les conditions d'hybridation spécifiques ou de forte stringence seront telles qu'elles assurent au moins 75 %, de préférence 80 %, 85 %, 90 %, 95 %, 98 % ou 99 % d'identité après alignement optimal entre l'une des deux séquences et sa séquence complémentaire.

Une hybridation dans des conditions de forte stringence signifie que les conditions de température et de force ionique sont choisies de telle manière qu'elles permettent le maintien de l'hybridation entre deux fragments d'ADN complémentaires. A titre illustratif, des conditions de forte stringence de l'étape d'hybridation aux fins de définir les fragments polynucléotidiques décrits ci-dessus, sont avantageusement les suivantes. L'hybridation ADN- ADN ou ADN-ARN est réalisée en deux étapes : (1) préhybridation à 42°C pendant 3 heures en tampon phosphate (20 mM, pH 7,5) contenant 5 x SSC (1 x SSC correspond à une solution 0,15 M NaCl + 0,015 M citrate de sodium), 50 % de formamide, 7 % de sodium dodécyl sulfate (SDS), 10 x Denhardt's, 5 % de dextran sulfate et 1 % d'ADN de sperme de saumon ; (2) hybridation proprement dite pendant 20 heures à une température dépendant de la taille de la sonde (i.e. : 42°C, pour une sonde de taille > 100 nucléotides) suivie de 2 lavages de 20 minutes à 20°C en 2 x SSC + 2 % SDS, 1 lavage de 20 minutes à 20°C en 0,1 x SSC + 0,1 % SDS. Le dernier lavage est pratiqué en 0,1 x SSC + 0,1 % SDS pendant 30 minutes à 60°C pour une sonde de taille > 100 nucléotides. Les conditions d'hybridation de forte stringence décrites ci-dessus pour un polynucléotide de taille définie, peuvent être adaptées par l'homme du métier pour des oligonucléotides de taille plus grande ou plus petite, selon l'enseignement de Sambrook et al. (1989, Molecular cloning : a laboratory manual. 2^nd Ed. Cold Spring Harbor). De plus, par fragment représentatif de séquences selon l'invention, on entend désigner tout fragment nucléotidique présentant au moins 15 nucléotides, de préférence au moins 20, 25, 30, 50, 75, 100, 150, 200, 300 et 450 nucléotides consécutifs de la séquence dont il est issu. Par fragment représentatif, on entend en particulier une séquence nucléique codant pour un fragment biologiquement actif d'un polypeptide, tel que défini plus loin. Par fragment représentatif, on entend également les séquences intergéniques, et en particulier les séquences nucléotidiques portant les signaux de régulation (promoteurs, terminateurs, voire enhancers, ...). Parmi lesdits fragments représentatifs, on préfère ceux ayant des séquences nucléotidiques correspondant à des cadres ouverts de lecture, dénommés séquences ORFs (ORF pour « Open Reading Frame »), compris en général entre un codon d'initiation et un codon stop, ou entre deux codons stop, et codant pour des polypeptides, de préférence d'au moins 100 acides aminés, tels que par exemple, sans s'y limiter, les séquences ORFs qui seront décrites par la suite.

La numérotation des séquences nucléotidiques ORFs qui sera utilisée par la suite dans la présente description correspond à la numérotation des séquences d'acides aminés des protéines codées par lesdites ORFs pour les les séquences SEQ ïï) N° 42 à SEQ ïï) N° 3855. La numérotation des séquences nucléotidiques ORFs SEQ ïï) N° 5835 à SEQ ïï) N° 10784 sera utilisée par la suite dans la présente description pour la numérotation des séquences d'acides aminés des protéines codées par lesdites ORFs SEQ ïï) N° 5835 à SEQ ïï) N° 10784.

Les fragments représentatifs selon l'invention peuvent être obtenus par exemple par amplification spécifique telle que la PCR ou après digestion par des enzymes de restriction appropriées de séquences nucléotidiques selon l'invention, cette méthode étant décrite en particulier dans l'ouvrage de Sambrook et al.. Lesdits fragments représentatifs peuvent également être obtenus par synthèse chimique lorsque leur taille n'est pas trop importante, selon des méthodes bien connues de l'homme du métier.

Parmi les séquences contenant des séquences de l'invention, ou des fragments représentatifs, on entend également les séquences qui sont naturellement encadrées par des séquences qui présentent au moins 75 %, 80 %, 85 %, 90 %, 95 %, 98 % ou 99 % d'identité avec les séquences selon l'invention.

Par séquence nucléotidique modifiée, on entend toute séquence nucléotidique obtenue par mutagénèse selon des techniques bien connues de l'homme du métier, et comportant des modifications par rapport aux séquences normales, de préférence au plus 10 % de nucléotides modifiés par rapport à ces séquences normales, par exemple des mutations dans les séquences régulatrices et/ou promotrices de l'expression du polypeptide, notamment conduisant à une modification du taux d'expression ou de l'activité dudit polypeptide.

Par séquence nucléotidique modifiée, on entend également toute séquence nucléotidique codant pour un polypeptide modifié tel que défini ci-après.

Les fragments représentatifs selon l'invention peuvent également être des sondes ou amorces, qui peuvent être utilisées dans des procédés de détection, d'identification, de dosage ou d'amplification de séquences nucléiques.

Une sonde ou amorce se définit, au sens de l'invention, comme étant un fragment d'acides nucléiques simple brin ou un fragment double brin dénaturé comprenant par exemple de 12 bases à quelques kb, notamment de 15 à quelques centaines de bases, de préférence de 15 à 50 ou 100 bases, et possédant une spécificité d'hybridation dans des conditions déterminées pour former un complexe d'hybridation avec un acide nucléique cible.

Les sondes et amorces selon l'invention peuvent être marquées directement ou indirectement par un composé radioactif ou non radioactif par des méthodes bien connues de l'homme du métier, afin d'obtenir un signal détectable et/ou quantifiable (brevet FR 78 10975 et bDNA de Chiron EP 225 807 et EP 510 085).

Les séquences non marquées de polynucléotides selon l'invention peuvent être utilisées directement comme sonde ou amorce.

Les séquences sont généralement marquées pour obtenir des séquences utilisables pour de nombreuses applications. Le marquage des amorces ou des sondes selon l'invention est réalisé par des éléments radioactifs ou par des molécules non radioactives.

Parmi les isotopes radioactifs utilisés, on peut citer le P, le P, le S, le H ou le ¹²⁵I. Les entités non radioactives sont sélectionnées parmi les ligands tels la biotine, l'avidine, la streptavidine, la dioxygénine, les haptènes, les colorants, les agents luminescents tels que les agents radioluminescents, chémoluminescents, bioluminescents, fluorescents, phosphorescents.

Les polynucléotides selon l'invention peuvent ainsi être utilisés comme amorce et/ou sonde dans des procédés mettant en oeuvre notamment la technique de PCR (amplification en chaîne par polymérase) (Rolfs et al., 1991, Berlin : Springer-Verlag). Cette technique nécessite le choix de paires d'amorces oligonucléotidiques encadrant le fragment qui doit être amplifié. On peut, par exemple, se référer à la technique décrite dans le brevet américain U.S. N° 4,683,202. Les fragments amplifiés peuvent être identifiés, par exemple après une électrophorèse en gel d'agarose ou de polyacrylamide, ou après une technique chromatographique comme la filtration sur gel ou la chromatographie échangeuse d'ions, puis séquences. La spécificité de l'amplification peut être contrôlée en utilisant les séquences nucléotidiques de polynucléotides de l'invention comme matrice, des plasmides contenant ces séquences ou encore les produits d'amplification dérivés. Les fragments nucléotidiques amplifiés peuvent être utilisés comme réactifs dans des réactions d'hybridation afin de mettre en évidence la présence, dans un échantillon biologique, d'un acide nucléique cible de séquence complémentaire à celle desdits fragments nucléotidiques amplifiés.

L'invention vise également les acides nucléiques susceptibles d'être obtenus par amplification à l'aide d'amorces selon l'invention. D'autres techniques d'amplification de l'acide nucléique cible peuvent être avantageusement employées comme alternative à la PCR (PCR-like) à l'aide de couple d'amorces de séquences nucléotidiques selon l'invention. Par PCR-like on entend désigner toutes les méthodes mettant en œuvre des reproductions directes ou indirectes des séquences d'acides nucléiques, ou bien dans lesquelles les systèmes de marquage ont été amplifiés, ces techniques sont bien entendu connues. En général, il s'agit de l'amplification de TADN par une polymérase ; lorsque l'échantillon d'origine est un ARN il convient préalablement d'effectuer une transcription reverse. Il existe actuellement de très nombreux procédés permettant cette amplification, comme par exemple la technique SDA (Strand Displacement Amplification) ou technique d'amplification à déplacement de brin (Walker et al, 1992, Nucleic Acids Res., 20:1691), la technique TAS (Transcription-based Amplification System) décrite par Kwoh et al. (1989, Proc. Natl. Acad. Sci. USA, 86, 1173), la technique 3SR (Self- Sustained Séquence Replication) décrite par Guatelli et al. (1990, Proc. Natl. Acad. Sci. USA, 87: 1874), la technique NASBA (Nucleic Acid Séquence Based Amplification) décrite par Kievitis et al. (1991, J. Virol. Methods, 35, 273), la technique TMA (Transcription Mediated Amplification), la technique LCR (Ligase Chain Reaction) décrite par Landegren et al. (1988, Science, 241, 1077), la technique de RCR (Repair Chain Reaction) décrite par Segev (1992, Kessler C. Springer Verlag, Berlin, New- York, 197-205), la technique CPR (Cycling Probe Reaction) décrite par Duck et al. (1990, Biotechniques, 9, 142), la technique d'amplification à la Q-béta-réplicase décrite par Miele et al. (1983, J. Mol. Biol., 171, 281). Certaines de ces techniques ont depuis été perfectionnées.

Dans le cas où le polynucléotide cible à détecter est un ARNm, on utilise avantageusement, préalablement à la mise en oeuvre d'une réaction d'amplification à l'aide des amorces selon l'invention ou à la mise en oeuvre d'un procédé de détection à l'aide des sondes de l'invention, une enzyme de type transcriptase inverse afin d'obtenir un ADNc à partir de l'ARNm contenu dans l'échantillon biologique. L'ADNc obtenu servira alors de cible pour les amorces ou les sondes mises en oeuvre dans le procédé d'amplification ou de détection selon l'invention.

La technique d'hybridation de sondes peut être réalisée de manières diverses (Matthews et al., 1988, Anal. Biochem., 169, 1-25). La méthode la plus générale consiste à immobiliser l'acide nucléique extrait des cellules de différents tissus ou de cellules en culture sur un support (tels que la nitrocellulose, le nylon, le polystyrène) et à incuber, dans des conditions bien définies, l'acide nucléique cible immobilisé avec la sonde. Après l'hybridation, l'excès de sonde est éliminé et les molécules hybrides formées sont détectées par la méthode appropriée (mesure de la radioactivité, de la fluorescence ou de l'activité enzymatique liée à la sonde).

Selon un autre mode de mise en œuvre des sondes nucléiques selon l'invention, ces dernières peuvent être utilisées comme sondes de capture. Dans ce cas, une sonde, dite « sonde de capture », est immobilisée sur un support et sert à capturer par hybridation spécifique l'acide nucléique cible obtenu à partir de l'échantillon biologique à tester et l'acide nucléique cible est ensuite détecté grâce à une seconde sonde, dite « sonde de détection », marquée par un élément facilement détectable. Parmi les fragments d'acides nucléiques intéressants, il faut ainsi citer en particulier les oligonucléotides anti-sens, c'est-à-dire dont la structure assure, par hybridation avec la séquence cible, une inhibition de l'expression du produit correspondant. Il faut également citer les oligonucléotides sens qui, par interaction avec des protéines impliquées dans la régulation de l'expression du produit correspondant, induiront soit une inhibition, soit une activation de cette expression.

De façon préférée, les sondes ou amorces selon l'invention sont immobilisées sur un support, de manière covalente ou non covalente. En particulier, le support peut être une puce à ADN ou un filtre à haute ou moyenne densité, également objet de la présente invention (brevets WO 97/29212, WO 98/27317, WO 97/10365 et WO 92/10588).

On entend désigner par puce à ADN ou filtre haute densité, un support sur lequel sont fixées des séquences d'ADN, chacune d'entre elles pouvant être repérée par sa localisation géographique. Ces puces ou filtres diffèrent principalement par leur taille, le matériau du support, et éventuellement le nombre de séquences d'ADN qui y sont fixées.

On peut fixer les sondes ou amorces selon la première invention sur des supports solides, en particulier les puces à ADN, par différents procédés de fabrication. En particulier, on peut effectuer une synthèse in situ par adressage photochimique ou par jet d'encre. D'autres techniques consistent à effectuer une synthèse ex situ et à fixer les sondes sur le support de la puce à ADN par adressage mécanique, électronique ou par jet d'encre. Ces différents procédés sont bien connus de l'homme du métier.

Une séquence nucléotidique (sonde ou amorce) selon l'invention permet donc la détection et/ou l'amplification de séquences nucléiques spécifiques. En particulier, la détection de cesdites séquences est facilitée lorsque la sonde est fixée sur une puce à ADN, ou à un filtre haute densité.

L'utilisation de puces à ADN ou de filtres à haute densité permet en effet de déterminer l'expression de gènes dans un organisme présentant une séquence génomique proche de P. luminescens et le typage de la souche en cause.

La séquence génomique de P. luminescens, complétée par l'identification des gènes de ces organismes, telles que présentée dans la présente invention, servent de base à la construction de ces puces à ADN ou filtre.

La préparation de ces filtres ou puces consiste à synthétiser des oligonucléotides, correspondant aux extrémités 5' et 3' des gènes ou à des fragments plus internes pour amplifier des fragments d'une taille adaptée, par exemple comprise environ entre 300 et 800 bases. Ces oligonucléotides sont choisis en utilisant la séquence génomique et ses annotations divulguées par la présente invention. La température d'appariement de ces oligonucléotides aux places correspondantes sur PADN doit être approximativement la même pour chaque oligonucleotide. Ceci permet de préparer des fragments d'ADN correspondant à chaque gène par l'utilisation de conditions de PCR appropriées dans un environnement hautement automatisé. Les fragments amplifiés sont ensuite immobilisés sur des filtres ou des supports en verre, silicium ou polymères synthétiques et ces milieux sont utilisés pour l'hybridation. La disponibilité de tels filtres et/ou puces et de la séquence génomique correspondante annotée permet d'étudier l'expression de grands ensembles, voire de la totalité des gènes de Photorhabdus luminescens, notamment de P. luminescens TTOl, en préparant les ADNs complémentaires, et en les hybridant à l'ADN ou aux oligonucléotides immobilisés sur les filtres ou les puces. De même, les filtres et/ou les puces permettent d'étudier la variabilité des souches ou des espèces, en préparant TADN de ces organismes et en les hybridant à l'ADN ou aux oligonucléotides immobilisés sur les filtres ou les puces.

Les différences entre les séquences génomiques des différentes souches ou espèces peuvent grandement affecter l'intensité de l'hybridation et, par conséquent, perturber l'interprétation des résultats. Il peut donc être nécessaire d'avoir la séquence précise des gènes de la souche que l'on souhaite étudier. La méthode de détection des gènes décrite plus loin en détail, impliquant la détermination de la séquence de fragments aléatoires d'un génome, et les organisant d'après la séquence du génome de P. luminescens, notamment de P. luminescens TTOl, divulguée dans la présente invention, peut être très utile.

Les séquences nucléotidiques selon l'invention peuvent être utilisées dans des puces à ADN pour effectuer l'analyse de mutations. Cette analyse repose sur la constitution de puces capables d'analyser chaque base d'une séquence nucléotidique selon l'invention. On pourra notamment à cette fin mettre en œuvre les techniques de microséquençage sur puce à ADN. Les mutations sont détectées par extension d'amorces immobilisées hybridant à la matrice des séquences analysées, juste en position adjacente de celle du nucleotide muté recherché. Une matrice simple brin, ARN ou ADN, des séquences à analyser sera avantageusement préparée selon des méthodes classiques, à partir de produits amplifiés selon les techniques de type PCR. Les matrices d'ADN simple brin, ou d'ARN ainsi obtenues sont alors déposées sur la puce à ADN, dans des conditions permettant leur hybridation spécifique aux amorces immobilisées. Une polymérase thermostable, par exemple la Tth ou la Taq ADN polymérase, étend spécifiquement l'extrémité 3' de l'amorce immobilisée avec un analogue de nucleotide marqué complémentaire du nucleotide en position du site variable ; par exemple, un cyclage thermique est réalisé en présence des didéoxyribonucléotides fluorescents. Les conditions expérimentales seront adaptées notamment aux puces employées, aux amorces immobilisées, aux polymérases employées, et au système de marquage choisi. Un avantage du microséquençage, par rapport aux techniques basées sur l'hybridation de sondes, est qu'il permet d'identifier tous les nucléotides variables avec une discrimination optimale dans des conditions de réactions homogènes ; utilisé sur des puces à ADN, il permet une résolution et une spécificité optimales pour la détection routinière et industrielle de mutations en multiplex. Une puce à ADN ou un filtre peut être un outil extrêmement intéressant pour la détermination, la détection et/ou l'identification d'un micro-organisme. Ainsi, on préfère également les puces à ADN selon l'invention qui contiemient en outre au moins une séquence nucléotidique d'un micro-organisme autre que Photorhabdus luminescens, immobilisée sur le support de ladite puce. De préférence, le micro- organisme choisi l'est parmi les bactéries du genre Photorhabdus (ci-après désignées comme bactéries associées à P. luminescens), ou les variants de Photorhabdus luminescens TTOl.

Une puce à ADN ou un filtre selon l'invention est un élément très utile de certains kits ou nécessaires pour la détection et/ou l'identification de micro-organismes, en particulier les bactéries appartenant à l'espèce Photorhabdus luminescens, également objet de l'invention.

Par ailleurs, les puces à ADN ou les filtres selon l'invention, contenant des sondes ou amorces spécifiques de Photorhabdus luminescens, sont des éléments très avantageux de kits ou nécessaires pour la détection et/ou la quantification de l'expression de gènes de Photorhabdus luminescens.

En effet, le contrôle de l'expression des gènes est un point critique pour optimiser la croissance et le rendement d'une souche, soit en permettant l'expression d'un ou plusieurs gènes nouveaux, soit en modifiant l'expression de gènes déjà présents dans la cellule. La présente invention fournit l'ensemble des séquences naturellement actives chez P. luminescens permettant l'expression des gènes. Elle permet ainsi la détermination de l'ensemble des séquences exprimées chez P. luminescens. Elle fournit également un outil permettant de repérer les gènes dont l'expression suit un schéma donné. Pour réaliser cela, l' ADN de tout ou partie des gènes de P. luminescens peut être amplifié grâce à des amorces selon l'invention, puis fixé à un support comme par exemple le verre ou le nylon ou une puce à ADN, afin de construire un outil permettant de suivre le profil d'expression de ces gènes. Cet outil, constitué de ce support contenant les séquences codantes sert de matrice d'hybridation à un mélange de molécules marquées reflétant les ARNs messagers exprimés dans la cellule (en particulier les sondes marquées selon l'invention). En répétant cette expérience à différents instants et en combinant l'ensemble de ces données par un traitement approprié, on obtient alors les profils d'expression de l'ensemble de ces gènes. La connaissance des séquences qui suivent un schéma de régulation donné peut aussi être mise à profit pour rechercher de manière dirigée, par exemple par homologie, d'autres séquences suivant globalement, mais de manière légèrement différente le même schéma de régulation. En complément, il est possible d'isoler chaque séquence de contrôle présente en amont des segments servant de sondes et d'en suivre l'activité à l'aide de moyen approprié comme un gène raporteur (luciférase, β-galactosidase, GFP). Ces séquences isolées peuvent ensuite être modifiées et assemblées par ingénierie métabolique avec des séquences d'intérêt en vue de leur expression optimale.

L'invention concerne également les polypeptides codés par une séquence nucléotidique selon l'invention, de préférence, par un fragment représentatif des séquences précédentes et correspondant à une séquence ORF. En particulier, les polypeptides de Photorhabdus luminescens TTOl de SEQ ïï) N° 42 à SEQ ïï) N° 3855 ou codés par les SEQ ïï) N° 5835 à SEQ ï⁾ N° 10784 sont objet de l'invention.

L'invention comprend également les polypeptides caractérisés en ce qu'ils comprennent un polypeptide choisi parmi : a) un polypeptide de séquence SEQ ïï) N° 42 à SEQ ïï) N° 3855 ou codé par une séquence SEQ ïï) N° 5835 à SEQ ïï) N° 10784 ; b) un polypeptide présentant au moins 80 % de préférence 85 %, 90 %, 95 % et 98 % d'identité avec un polypeptide selon l'invention ; c) un fragment d'au moins 5 acides aminés d'un polypeptide tel que défini en a) ; d) un fragment biologiquement actif d'un polypeptide tel que défini en a) ; et e) un polypeptide tel que défini en a), b), c) ou d) modifié. Les séquences nucléotidiques codant pour les polypeptides décrits précédemment sont également objet de l'invention.

Dans la présente description, les termes polypeptides, séquences polypeptidiques, peptides et protéines sont interchangeables. Le terme polypeptide comprend toute séquence d'acides aminés permettant de générer une réponse anticorps. II doit être compris que l'invention ne concerne pas les polypeptides sous forme naturelle, c'est-à-dire qu'ils ne sont pas pris dans leur environnement naturel. En revanche, elle concerne ceux qui ont pu être isolés ou obtenus par purification à partir de sources naturelles, ou bien obtenus par recombinaison génétique, ou par synthèse chimique, et qu'ils peuvent alors comporter des acides aminés non naturels comme cela sera décrit plus loin.

Par polypeptide présentant un certain pourcentage d'identité avec un autre, que l'on désignera également par polypeptide homologue, on entend désigner les polypeptides présentant par rapport aux polypeptides naturels, certaines modifications, en particulier une délétion, addition ou substitution d'au moins un acide aminé, une troncation, un allongement, une solution chimérique et/ou une mutation, ou les polypeptides présentant des modifications post-traductionnelles. Parmi les polypeptides homologues, on préfère ceux dont la séquence d'acides aminés présente au moins 80 %, de préférence 85 %, 90 %, 95 %, 98 % ou 99 % d'identité après alignement optimal avec les séquences d'acides aminés des polypeptides selon l'invention. Dans le cas d'une substitution, un ou plusieurs acide(s) aminé(s) consécutifs) ou non consécutifs) peuvent être remplacés par des acides aminés « équivalents ». L'expression « acides aminés équivalents » vise ici à désigner tout acide aminé susceptible d'être substitué à l'un des acides aminés de la structure de base sans cependant modifier essentiellement les activités biologiques des peptides correspondant telles qu'elles seront définies par la suite.

Ces acides aminés équivalents peuvent être déterminés soit en s'appuyant sur leur homologie de structure avec les acides aminés auxquels ils se substituent, soit sur des résultats d'essais comparatifs d'activité biologique entre les différents polypeptides susceptibles d'être effectués.

A titre d'exemple, on mentionne les possibilités de substitution susceptibles d'être effectuées sans qu'il résulte en une modification approfondie de l'activité biologique du polypeptide modifié correspondant. On peut remplacer ainsi la leucine par la valine ou l'isoleucine, l'acide aspartique par l'acide glutamine, la glutamine par l'asparagine, Targinine par la lysine, etc., les substitutions inverses étant naturellement envisageables dans les mêmes conditions.

Les polypeptides homologues correspondent également aux polypeptides codés par les séquences nucléotidiques présentant un certain pourcentage d'identité avec les séquences nucléotidiques de l'invention ou identiques, telles que définies précédemment et comprennent ainsi dans la présente définition des polypeptides mutés ou correspondant à des variations inter ou intra espèces, pouvant exister chez Photorhabdus, et qui correspondent notamment à des troncatures, substitutions, délétions et/ou additions, d'au moins un résidu d'acides aminés. Il est entendu que l'on calcule le pourcentage d'identité entre deux polypeptides de la même façon qu'entre deux séquences d'acides nucléiques. Ainsi, le pourcentage d'identité entre deux polypeptides est calculé après alignement optimal de ces deux séquences, sur une fenêtre d'homologie maximale. Pour définir ladite fenêtre d'homologie maximale, on peut utiliser les mêmes algorithmes que pour les séquences d'acide nucléique.

Par fragment biologiquement actif d'un polypeptide selon l'invention, on entend désigner en particulier un fragment de polypeptide, tel que défini ci-après, présentant au moins une des caractéristiques biologiques des polypeptides selon l'invention, notamment en ce qu'il est capable d'exercer de manière générale une activité même partielle, telle que par exemple :

- une activité enzymatique (métabolique), une activité pouvant être impliquée dans la biosynthèse ou la biodégradation de composés organiques ou inorganiques, ou de préférence une activité toxique ou antibiotique, notamment pour les insectes ou micro-organismes (bactéries ou champignons), ou encore une activité impliquée dans la biosynthèse de ces toxines ou antibiotiques ; de telles protéines à activité enzymatique pourront notamment être utilisées dans des procédés de criblage et/ou de sélection de composés capables de modifier cette activité, en particulier de l'inhiber.

- une activité structurelle (enveloppe cellulaire, molécule chaperonne, ribosome). Les protéines correspondant notamment à des protéines extramembranaires pourront être en particulier utilisées comme immunogène pour la production d'anticorps, mono- ou polyclonaux dirigés spécifiquement contre ces protéines extramembranaires ;

- une activité de transport (d'énergie, d'ion) ; ou dans la sécrétion de protéine ; - une activité dans le processus de réplication, amplification, préparation, transcription, traduction ou maturation, notamment de l'ADN, de l'ARN ou des protéines.

Par fragment de polypeptide selon l'invention, on entend désigner un polypeptide comportant au minimum 5 acides aminés, de préférence 10, 15, 25, 50, 100 et 150 acides aminés.

Les fragments de polypeptides peuvent correspondre à des fragments isolés ou purifiés naturellement présents dans les souches de Photorhabdus, ou à des fragments qui peuvent être obtenus par clivage dudit polypeptide par une enzyme protéolitique telle que la trypsine ou la chymotrypsine ou la collagénase, par un réactif chimique (bromure de cyanogène, CNBr) ou en plaçant ledit polypeptide dans un environnement très acide (par exemple à pH = 2,5). Des fragments polypeptidiques peuvent également être préparés par synthèse chimique, à partir d'hôtes transformés par un vecteur d'expression selon l'invention qui contiennent un acide nucléique permettant l'expression dudit fragment, et placé sous le contrôle des éléments de régulation et/ou d'expression appropriés.

Par « polypeptide modifié » d'un polypeptide selon l'invention, on entend désigner un polypeptide obtenu par recombinaison génétique ou par synthèse chimique comme décrit plus loin, qui présente au moins une modification par rapport à la séquence normale et de préférence au plus 10 % d'acides aminés modifiés par rapport à la séquence normale. Ces modifications peuvent être notamment portées sur des acides aminés nécessaires pour la spécificité ou l'efficacité de l'activité, ou à l'origine de la conformation structurale, de la charge, ou de l'hydrophobicité du polypeptide selon l'invention. On peut ainsi créer des polypeptides d'activité équivalente, augmentée ou diminuée, ou de spécificité équivalente, plus étroite ou plus large. Parmi les polypeptides modifiés, il faut citer les polypeptides dans lesquels jusqu'à cinq acides aminés peuvent être modifiés, tronqués à l'extrémité N ou C-terminale, ou bien délétés, ou ajoutés.

Comme cela est indiqué, les modifications d'un polypeptide ont pour objectif notamment :

- de permettre sa mise en œuvre dans des procédés de biosynthèse ou de biodégradation de composés organiques ou inorganiques, dans la biosynthèse de toxines ou d'antibiotiques,

- de permettre sa mise en œuvre dans des procédés de réplication, d'amplification, de réparation et règle de transcription, de traduction, ou de maturation notamment de l'ADN, l'ARN, ou de protéines ; de permettre sa sécrétion améliorée,

- de modifier sa solubilité, l'efficacité ou la spécificité de son activité, ou encore de faciliter sa purification.

La synthèse chimique présente également l'avantage de pouvoir utiliser des acides aminés non naturels ou des liaisons non peptidiques. Ainsi, il peut être intéressant d'utiliser des acides aminés non naturels, par exemple sous forme D, ou des analogues d'acides aminés, notamment des formes soufrées.

L'invention concerne en outre les séquences nucléiques ou peptidiques selon la présente invention à l'exception des séquences nucléiques ou peptidiques décrites dans les documents WO 99/54472, WO 99/42589, WO 99/03328, WO 98/08932 et EP 0 823 215.

La présente invention fournit la séquence nucléotidique du génome de Photorhabdus luminescens TTOl sous forme de 41 contigs ou sous forme de 9 contigs, ainsi que certaines séquences polypeptidiques.

Les séquences nucléiques ou peptidiques ci-après caractérisées par leur fonction peuvent être également identifiées par leur séquence nucléotidique et d'acides aminés en se reportant au tableau I.

D'une manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide de Photorhabdus luminescens TTOl à activité de type toxine et/ou antibiotique, ou impliqué dans la synthèse de ces toxines et/ou antibiotiques.

D'une manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans la biosynthèse des acides aminés.

De manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans la biosynthèse des co facteurs, groupes prosthétiques et transporteurs.

De manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide d'enveloppe cellulaire ou présent à la surface de Photorhabdus luminescens TTOl ou pour un de ses fragments.

De manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans la machinerie cellulaire.

De manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans le métabolisme intermédiaire central.

De manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans le métabolisme énergétique. De manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans le métabolisme des acides gras et des phospholipides. De manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans le métabolisme des nucléotides, des purines, des pyrimidines ou nucléosides.

De manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans les fonctions de régulation.

De manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans le processus de réplication. De manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans le processus de transcription.

De manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans le processus de traduction.

De manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans le processus de transport et de liaison des protéines. De manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans l'adaptation aux conditions atypiques.

De manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments dans la sensibilité aux médicaments et analogues.

De manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans les fonctions relatives aux transposons.

De manière préférée, l'invention est relative à une séquence nucléotidique selon l'invention, caractérisée en ce qu'elle code pour un polypeptide spécifique de Photorhabdus luminescens TTOl ou un de ses fragments.

Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments activité de type toxine et/ou antibiotique, ou impliqué dans la synthèse de ces toxines et/ou antibiotiques. Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans la biosynthèse des acides aminés.

Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans la biosynthèse des cofacteurs, groupes prosthétiques et transporteurs.

Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide d'enveloppe cellulaire ou de surface de Photorhabdus luminescens TTOl ou un de ses fragments.

Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans la machinerie cellulaire.

Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans le métabolisme intermédiaire central. Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans le métabolisme énergétique. Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans le métabolisme des acides gras et des phospholipides. Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans le métabolisme des nucléotides, des purines, des pyrimidines ou nucléosides.

Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans les fonctions de régulation.

Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans le processus de réplication.

Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans le processus de transcription.

Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans le processus de traduction. Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans le processus de transport et de liaison des protéines.

Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans l'adaptation aux conditions atypiques.

Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments dans la sensibilité aux médicaments et analogues.

Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide de Photorhabdus luminescens TTOl ou un de ses fragments impliqué dans les fonctions relatives aux transposons.

Sous un autre aspect, de manière préférée, l'invention a pour objet un polypeptide selon l'invention, caractérisé en ce qu'il s'agit d'un polypeptide spécifique de Photorhabdus luminescens TTOl ou un de ses fragments. L'invention a également pour objet les opérons impliqués dans la synthèse d'antibiotiques et/ou de toxines.

Le tableau I fournit la liste de certains polypeptides selon l'invention, ainsi que leur localisation dans les contigs représentés par SEQ ïï) N° 1 à SEQ ïï) N° 41, et les analogies observées après comparaison dans les bases de données. Le tableau ïï fournit la liste de certains polypeptides selon l'invention, ainsi que leur localisation dans les contigs représentés par SEQ ïï) N° 5826 à SEQ ïï) N° 5834, et les analogies observées après comparaison dans les bases de données. Dans le tableau ïï, les contig 1 à 9 sont identifiées par les séquences SEQ ïï) N° 5826 à SEQ ïï) N° 5834. De manière tout à fait préférée, l'invention a également pour objet les polypeptides dont les fonctions annotées au tableau I, dernière colonne, ou dont les fonctions annotées au tableau ïï, avant-dernière colonne, correspondent à des activités de type toxine et/ou antibiotique, ou à polypeptides impliqués dans la synthèse de ces toxines et/ou antibiotiques, polypeptides de préférence choisis parmi : a) les polypeptides de séquence SEQ ïï) N° 61, SEQ ïï) N° 62, SEQ ï) N° 67, SEQ ïï) N° 171, SEQ ïï) N° 221, SEQ ïï) N° 268, SEQ ïï) N° 288, SEQ ïï) N° 380, SEQ ïï) N° 426, SEQ ïï) N° 438, SEQ ïï) N° 448, SEQ ïï) N° 453, SEQ ïï) N° 455, SEQ ïï) N° 456, SEQ ïï) N° 458, SEQ ïï) N° 501, SEQ ïï) N° 516, SEQ ïï) N° 530, SEQ ïï) N° 542, SEQ ïï) N° 551, SEQ ïï) N° 720, SEQ ïï) N° 761, SEQ ïï⁾ N° 762, SEQ ïï) N° 814, SEQ ïï) N° 859, SEQ ïï) N° 860, SEQ ïï) N° 861, SEQ ïï⁾ N° 862, SEQ ïï) N° 869, SEQ ïï) N° 1079, SEQ ïï) N° 1168, SEQ ïï) N° 1174, SEQ ïï⁾ N° 1176, SEQ ïï) N° 1413, SEQ ïï) N° 1414, SEQ ïï) N° 1415, SEQ ïï) N° 1416, SEQ ïï⁾ N° 1417, SEQ ïï) N° 1457, SEQ ï) N° 1651, SEQ ïï⁾ N° 1856, SEQ ï⁾ N° 1869, SEQ ï⁾ N° 2021, SEQ ïï) N° 2080, SEQ ïï) N° 2152, SEQ ï) N° 2162, SEQ ïï⁾ N° 2173, SEQ ïï) N° 2251, SEQ ïï) N° 2295, SEQ ïï) N° 2306, SEQ ïï) N° 2317, SEQ ïï) N° 2328, SEQ ïï⁾ N° 2340, SEQ ïï) N° 2342, SEQ ïï) N° 2351, SEQ ï) N° 2500, SEQ ïï) N° 3228, SEQ ïï) N° 3230, SEQ ï) N° 3311, SEQ ïï) N° 3317, SEQ ï) N° 3318, SEQ ïï⁾ N° 3319, SEQ ïï) N° 3320, SEQ ïï) N° 3322, SEQ ïï) N° 3323, SEQ ïï) N° 3326, SEQ ïï⁾ N° 3327, SEQ ïï) N° 3328, SEQ ïï) N° 3375, SEQ ïï) N° 3376, SEQ ïï) N° 3377, SEQ ïï⁾ N° 3378, SEQ ïï) N° 3422, SEQ ïï) N° 3489, SEQ ïï) N° 3503, SEQ ïï) N° 3609, SEQ ïï) N° 3623, SEQ ïï) N° 3624, SEQ ïï) N° 3772, SEQ ïï) N° 3783, SEQ ïï) N° 3788 et SEQ ïï) N° 3794 ; ou b) les polypeptides codées par les séquences SEQ ïï) N° 5835 à SEQ ï) N° 10784 homologues aux séquences telles que définies en a) comme indiquées à la dernière colonne du tableau ïï.

La présente invention a également pour objet les séquences nucléotidiques et/ou de polypeptides selon l'invention, caractérisées en ce que lesdites séquences sont enregistrées sur un support d'enregistrement dont la forme et la nature facilitent la lecture, l'analyse et/ou l'exploitation de ladite ou desdites séquence(s). Ces supports peuvent également contenir d'autres informations extraites de la présente invention, notamment les analogies avec des séquences déjà connues, et/ou des informations concernant les séquences nucléotidiques et/ou de polypeptides d'une cellule de plante, d'un animal ou d'un micro-organisme autre que P. luminescens, notammment une cellule ou micro-organisme sensible à une toxine ou un antibiotique produit par P. luminescens, une bactérie du genre Photorhabdus, ou un variant de P. luminescens, ceci afin de faciliter l'analyse comparative et l'exploitation des résultats obtenus. Parmi cesdits supports d'enregistrement, on préfère en particulier les supports lisibles par un ordinateur, tels les supports magnétiques, optiques, électriques ou hybrides, en particulier les disquettes informatiques, les CD-ROM, les serveurs informatiques. De tels supports d'enregistrement sont également objet de l'invention.

Les supports d'enregistrement selon l'invention, avec les informations apportées, sont très utiles pour le choix d'amorces ou de sondes nucléotidiques pour la détermination de gènes dans Photorhabdus luminescens TTOl ou souches proches de cet organisme. De même, l'utilisation de ces supports pour l'étude du polymorphisme génétique de souches proches de Photorhabdus luminescens TTOl, en particulier par la détermination des régions de colinéarité, est très utile dans la mesure où ces supports fournissent non seulement la séquence nucléotidique du génome de Photorhabdus luminescens TTOl, mais également l'organisation génomique dans ladite séquence.

Ainsi, les utilisations de supports d'enregistrement selon l'invention sont également des objets de l'invention. L'analyse d'homologie entre différentes séquences s'effectue en effet avantageusement à l'aide de logiciels de comparaison de séquences, tels le logiciel

Blast, ou les logiciels de la trousse GCG, décrits précédemment.

L'invention vise également les vecteurs de clonage et/ou d'expression, qui contiennent une séquence nucléotidique selon l'invention. Les vecteurs selon l'invention comportent de préférence des éléments qui permettent l'expression et/ou la sécrétion des séquences nucléotidiques dans une cellule hôte déterminée.

Le vecteur doit alors comporter un promoteur, des signaux d'initiation et de terminaison de la traduction, ainsi que des régions appropriées de régulation de la transcription. Il doit pouvoir être maintenu de façon stable dans la cellule hôte et peut éventuellement posséder des signaux particuliers qui spécifient la sécrétion de la protéine traduite. Ces différents éléments sont choisis et optimisés par l'homme du métier en fonction de l'hôte cellulaire utilisé. A cet effet, les séquences nucléotidiques selon l'invention peuvent être insérées dans des vecteurs à réplication autonome au sein de l'hôte choisi, ou être des vecteurs intégratifs de l'hôte choisi.

De tels vecteurs sont préparés par des méthodes couramment utilisées par l'homme du métier, et les clones résultant peuvent être introduits dans un hôte approprié par des méthodes standards, telles que la lipofection, l'électroporation, le choc thermique, ou des méthodes chimiques. Les vecteurs selon l'invention sont par exemple des vecteurs d'origine plasmidique ou virale. Ils sont utiles pour transformer des cellules hôtes afin de cloner ou d'exprimer les séquences nucléotidiques selon l'invention.

Parmi ces vecteurs, on préfère également les vecteurs de clonage, et/ou d'expression selon l'invention, caractérisés en ce qu'ils contiennent une séquence nucléotidique choisie parmi les séquences SEQ ïï) N° 3856 à SEQ ïï⁾ N° 5825 , SEQ ïï) N° 5835 à SEQ ïï) N° 10784 ou leur fragment issu du génome de P. luminescens, notamment les séquences codant pour les polypeptides à activité toxine, antibiotiques ou impliqués dans ces activités, en particulier ceux précités dont les fonctions annotées au tableau I ci-après correspondent à ces activités. L'invention comprend également les cellules hôtes transformées par un vecteur selon l'invention.

L'hôte cellulaire peut être choisi parmi des systèmes procaryotes ou eucaryotes, par exemple les cellules bactériennes mais également les cellules de levure ou les cellules animales, en particulier les cellules de mammifères. On peut également utiliser des cellules d'insectes ou des cellules de plantes. Les cellules hôtes préférées selon l'invention sont en particulier les cellules procaryotes, de préférence les bactéries appartenant au genre Photorhabdus ou à l'espèce Photorhabdus luminescens, plus particulièrement Photorhabdus luminescens TTOl. L'invention concerne également les végétaux et les animaux, excepté l'Homme, qui comprennent une cellule transformée selon l'invention. Les cellules transformées selon l'invention sont utilisables dans des procédés de préparation de polypeptides recombinants selon l'invention. Les procédés de préparation d'un polypeptide selon l'invention sous forme recombinante, caractérisés en ce qu'ils mettent en œuvre un vecteur et/ou une cellule transformée par un vecteur selon l'invention sont eux-mêmes compris dans la présente invention. De préférence, on cultive une cellule transformée par un vecteur selon l'invention dans des conditions qui permettent l'expression dudit polypeptide et on récupère ledit peptide recombinant.

Ainsi qu'il a été dit, l'hôte cellulaire peut être choisi parmi des systèmes procaryotes ou eucaryotes. En particulier, il est possible d'identifier des séquences nucléotidiques selon l'invention, facilitant la sécrétion dans un tel système procaryote ou eucaryote. Un vecteur selon l'invention portant une telle séquence peut donc être avantageusement utilisé pour la production de protéines recombinantes, destinées à être sécrétées. En effet, la purification de ces protéines recombinantes d'intérêt sera facilitée par le fait qu'elles sont présentes dans le surnageant de la culture cellulaire plutôt qu'à l'intérieur des cellules hôtes.

On peut également préparer les polypeptides selon l'invention par synthèse chimique. Un tel procédé de préparation est également un objet de l'invention. L'homme du métier connaît les procédés de synthèse chimique, par exemple les techniques mettant en œuvre des phases solides (voir notamment Steward et al., 1984, Solid phase peptides synthesis, Pierce Chem. Company, Rockford, 111, 2ème éd., (1984)) ou des techniques utilisant des phases solides partielles, par condensation de fragments ou par une synthèse en solution classique. Les polypeptides obtenus par synthèse chimique et pouvant comporter des acides aminés non naturels correspondant sont également compris dans l'invention.

Les polypeptides hybrides selon l'invention sont très utiles pour obtenir des anticorps monoclonaux ou polyclonaux, capables de reconnaître spécifiquement les polypeptides selon l'invention.

Ces anticorps polyclonaux ou monoclonaux spécifiques peuvent être obtenus par les méthodes standards bien connues de l'homme de l'art, après immunisation d'un mammifère au moyen de ces polypeptides (ou de leur acide nucléique correspondant) ou par exemple selon la méthode classique de culture d'hybridome décrite par Kôhler et Milstein (1975, Nature, 256, 495) pour les anticorps monoclonaux.

De tels anticorps monoclonaux ou polyclonaux, leurs fragments, ou les anticorps chimériques, reconnaissant les polypeptides selon l'invention, sont également objets de l'invention.

Les anticorps selon l'invention sont par exemple des anticorps chimériques, des anticorps humanisés, des fragments Fab, ou F(ab')². Ils peuvent également se présenter sous forme d'immunoconjugués ou d'anticorps marqués afin d'obtenir un signal détectable et/ou quantifiable.

Ainsi, les anticorps selon l'invention peuvent être employés dans un procédé pour la détection et/ou l'identification de bactéries appartenant au genre Photorhabdus et/ou à l'espèce Photorhabdus luminescen dans un échantillon biologique, caractérisé en ce qu'il comprend les étapes suivantes : a) mise en contact de l'échantillon biologique avec un anticorps selon l'invention ; b) mise en évidence du complexe antigène-anticorps éventuellement formé.

Les anticorps selon la présente invention sont également utilisables afin de détecter une expression d'un gène de Photorhabdus luminescens TTOl. En effet, la présence du produit d'expression d'un gène reconnu par un anticorps spécifique dudit produit d'expression peut être détectée par la présence d'un complexe antigène- anticorps formé après la mise en contact de la souche de Photorhabdus luminescens TTOl avec un anticorps selon l'invention. La souche bactérienne utilisée peut avoir été « préparée », c'est-à-dire centrifugée, lysée, placée dans un réactif approprié pour la constitution du milieu propice à la réaction immunologique. En particulier, on préfère un procédé de détection de l'expression dans le gène, correspondant à un Western blot, pouvant être effectué après une électrophorèse sur gel de polyacrylamide d'un lysat de la souche bactérienne, en présence ou en l'absence de conditions réductrices (SDS- PAGE). Après migration et séparation des protéines sur le gel de polyacrylamide, on transfère lesdites protéines sur une membrane appropriée (par exemple en nylon) et on détecte la présence de la protéine ou du polypeptide d'intérêt, par mise en contact de ladite membrane avec un anticorps selon l'invention. Ainsi, la présente invention comprend également les kits ou nécessaires pour la mise en œuvre d'un procédé tel que décrit (de détection de l'expression d'un gène de Photorhabdus luminescens TTOl, ou pour la détection et/ou l'identification de bactéries appartenant à l'espèce Photorhabdus luminescens), comprenant les éléments suivants : a) un anticorps polyclonal ou monoclonal selon l'invention ; b) éventuellement, les réactifs pour la constitution du milieu propice à la réaction immunologique ; c) éventuellement, les réactifs permettant la mise en évidence des complexes antigène- anticorps produits par la réaction immunologique.

Les polypeptides et les anticorps selon l'invention peuvent avantageusement être immobilisés sur un support, notamment une puce à protéines. Une telle puce à protéines est un objet de l'invention, et peut également contenir au moins un polypeptide d'un micro-organisme autre que Photorhabdus luminescens ou un anticorps dirigé contre un composé d'un micro-organisme autre que Photorhabdus luminescens.

Les puces à protéines ou filtres à haute densité contenant des protéines selon l'invention peuvent être construites de la même manière que les puces à ADN selon l'invention. En pratique, on peut effectuer la synthèse des polypeptides directement fixés sur la puce à protéines, ou effectuer une synthèse ex situ suivie d'une étape de fixation sur ladite puce du polypeptide synthétisé. Cette dernière méthode est préférable, lorsque l'on désire fixer des protéines de taille importante sur le support, ces protéines étant avantageusement préparées par génie génétique. Toutefois, si l'on ne désire fixer que des peptides sur le support de ladite puce, il peut être plus intéressant de procéder à la synthèse desdits peptides directement in situ.

Les puces à protéines selon l'invention peuvent être avantageusement utilisées dans des kits ou nécessaires pour la détection et/ou l'identification de bactéries associées à l'espèce Photorhabdus luminescens ou à un micro-organisme, ou de façon plus générale dans des kits ou nécessaires pour la détection et/ou l'identification de micro-organismes. Lorsque l'on fixe les polypeptides selon l'invention sur les puces à ADN, on recherche la présence d'anticorps dans les échantillons testés, la fixation d'un anticorps selon l'invention sur le support de la puce à protéines permettant l'identification de la protéine dont ledit anticorps est spécifique.

De préférence, on fixe un anticorps selon l'invention sur le support de la puce à protéines, et on détecte la présence de l'antigène correspondant, spécifique de Photorhabdus luminescens.

Une puce à protéines ci-dessus décrite peut être utilisée pour la détection de produits de gènes, pour établir un profil d'expression desdits gènes, en complément d'une puce à ADN selon l'invention. Les puces à protéines selon l'invention sont également extrêmement utiles pour les expériences de protéomique, qui étudie les interactions entre les différentes protéines d'une cellule de plante, d'un animal, tel qu'un insecte, ou d'un micro-organisme autre que P. luminescens.

Ainsi, l'invention comprend également une puce à protéine selon l'invention, caractérisée en ce qu'elle contient en outre au moins un polypeptide d'une cellule de plante, d'un animal ou d'un micro-organisme autre que P. luminescens, immobilisé sur le support de ladite puce, de préférence ladite cellule ou micro-organisme autre est choisie parmi une cellule ou micro-organisme sensible à une toxine ou un antibiotique produit par P. luminescens.

De façon simplifiée, on fixe des peptides représentatifs des différentes protéines d'un organisme sur un support. Puis, on met ledit support en contact avec des protéines marquées, et après une étape optionnelle de rinçage, on détecte des interactions entre lesdites protéines marquées et les peptides fixés sur la puce à protéines.

Ainsi, les puces à protéines comprenant une séquence polypeptidique selon l'invention ou un anticorps selon l'invention sont objet de l'invention, ainsi que les kits ou nécessaires les contenant. La présente invention couvre également un procédé de détection et/ou d'identification de bactéries appartenant à l'espèce Photorhabdus luminescens dans un échantillon biologique, qui met en œuvre une séquence nucléotidique selon l'invention.

Il doit être entendu que le terme échantillon biologique concerne dans la présente invention les échantillons prélevés à partir d'un organisme vivant (en particulier sang, tissus, organes ou autres prélevés à partir d'un mammifère) ou un échantillon contenant du matériel biologique, c'est-à-dire de l'ADN ou de l'ARN. Un tel échantillon biologique comprend aussi les compositions alimentaires contenant des bactéries (par exemple les fromages, les produits laitiers), mais également des compositions alimentaires contenant des levures (bières, pains) ou autres. Le terme échantillon biologique concerne aussi les bactéries isolées à partir de ces prélèvements ou compositions alimentaires.

Le procédé de détection et/ou d'identification mettant en œuvre les séquences nucléotidiques selon l'invention peut être de diverse nature. On préfère un procédé comportant les étapes suivantes : a) éventuellement, isolement de l'ADN à partir de l'échantillon biologique à analyser, ou obtention d'un ADNc à partir de l'ARN de l'échantillon biologique ; b) amplification spécifique de l'ADN de bactéries appartenant à l'espèce Photorhabdus luminescens à l'aide d'au moins une amorce selon l'invention ; c) mise en évidence des produits d'amplification.

Ce procédé est basé sur l'amplification spécifique de l'ADN, en particulier par une réaction d'amplification en chaîne.

On préfère également un procédé comprenant les étapes suivantes : a) mise en contact d'une sonde nucléotidique selon l'invention avec un échantillon biologique, l'acide nucléique contenu dans l'échantillon biologique ayant, le cas échéant, préalablement été rendu accessible à l'hybridation, dans des conditions permettant l'hybridation de la sonde à l'acide nucléique d'une bactérie appartenant à Y espèce Photorhabdus luminescens ; b) mise en évidence de l'hybride éventuellement formé entre la sonde nucléotidique et l'ADN de l'échantillon biologique.

Un tel procédé ne doit pas être limité à la détection de la présence de l'ADN contenu dans l'échantillon biologique à tester, il peut être également mis en œuvre pour détecter l'ARN contenu dans ledit échantillon. Ce procédé englobe en particulier les Southern et Northern blot. Un autre procédé préféré selon l'invention comprend les étapes suivantes : a) mise en contact d'une sonde nucléotidique immobilisée sur un support selon l'invention avec un échantillon biologique, l'acide nucléique de l'échantillon, ayant, le cas échéant, été préalablement rendu accessible à l'hybridation, dans des conditions permettant l'hybridation de la sonde à l'acide nucléique d'une bactérie appartenant à l'espèce Photorhabdus luminescens ; b) mise en contact de l'hybride formé entre la sonde nucléotidique immobilisée sur un support et l'acide nucléique contenu dans l'échantillon biologique, le cas échéant après élimination de l'ADN de l'échantillon biologique n'ayant pas hybride avec la sonde, avec une sonde nucléotidique marquée selon l'invention ; c) mise en évidence du nouvel hybride formé à l'étape b).

Ce procédé est avantageusement utilisé avec une puce à ADN selon l'invention, l'acide nucléique recherché s'hybridant avec une sonde présente à la surface de ladite puce, et étant détecté par l'utilisation d'une sonde marquée. Ce procédé est avantageusement mis en œuvre en combinant une étape préalable d'amplification de l'ADN ou de l'ADN complémentaire obtenu éventuellement par transcription inverse, à l'aide d'amorces selon l'invention.

Ainsi, la présente invention englobe également les kits ou nécessaires pour la détection et/ou l'identification de bactéries appartenant à l'espèce Photorhabdus luminescens, caractérisé en ce qu'il comprend les éléments suivants : a) une sonde nucléotidique selon l'invention ; b) éventuellement, les réactifs nécessaires à la mise en œuvre d'une réaction d'hybridation ; c) éventuellement, au moins une amorce selon l'invention ainsi que les réactifs nécessaires à une réaction d'amplification de l'ADN.

De même, la présente invention englobe également les kits ou nécessaires pour la détection et/ou l'identification de bactéries appartenant à l'espèce Photorhabdus luminescens TTOl, caractérisé en ce qu'il comprend les éléments suivants : a) une sonde nucléotidique, dite sonde de capture, selon l'invention ; b) une sonde oligonucléotidique, dite sonde de révélation, selon l'invention ; c) éventuellement, au moins une amorce selon l'invention ainsi que les réactifs nécessaires à une réaction d'amplification de l'ADN.

Enfin, les kits ou nécessaires pour la détection et/ou l'identification de bactéries appartenant à l'espèce Photorhabdus luminescens, caractérisés en ce qu'ils comprennent les éléments suivants : a) au moins une amorce ou une sonde selon l'invention ; b) éventuellement, les réactifs nécessaires pour effectuer une réaction d'amplification d'ADN ; c) éventuellement, un composant permettant de vérifier la séquence du fragment amplifié, plus particulièrement une sonde oligonucléotidique selon l'invention, sont également objets de la présente invention.

De préférence, lesdites amorces et/ou sondes et/ou polypeptides et/ou anticorps selon la présente invention utilisés dans les procédés et/ou kits ou nécessaires selon la présente invention sont choisis parmi les amorces et/ou sondes et/ou polypeptides et/ou anticorps spécifiques de l'espèce Photorhabdus luminescens. De manière préférée, ces éléments sont choisis parmi les séquences nucléotidiques codant pour une protéine sécrétée, parmi les polypeptides sécrétés, ou parmi les anticorps dirigés contre des polypeptides sécrétés de Photorhabdus luminescens. La présente invention a également pour objet les souches de Photorhabdus luminescens TTOl contenant une ou plusieurs mutation(s) dans une séquence nucléotidique selon l'invention, en particulier une séquence ORF, ou leurs éléments régulateurs (en particulier promoteurs).

On préfère, selon la présente invention, les souches de Photorhabdus luminescens TTOl présentant une ou plusieurs mutation(s) dans les séquences nucléotidiques codant pour des polypeptides de préférence à activité de type toxine ou antibiotique, ou impliqués dans leur biosynthèse, ou encore sous un autre aspect impliqués dans la machinerie cellulaire, en particulier la sécrétion, le métabolisme intermédiaire central, le métabolisme énergétique, les processus de synthèse des acides aminés, de transcription et de traduction, de synthèse des polypeptides.

Lesdites mutations peuvent mener à une inactivation du gène, ou en particulier lorsqu'elles sont situées dans les éléments régulateurs dudit gène, à une surexpression de celui-ci.

Selon la présente invention, les souches de Photorhabdus luminescens TTOl présentant une ou plusieurs mutation(s) pourront être utilisées pour valider la fonction de gène sauvage de Photorhabdus luminescens.

L'invention concerne en outre l'utilisation d'une séquence nucléotidique selon l'invention, d'un polypeptide selon l'invention, d'un anticorps selon l'invention, et/ou d'une cellule selon l'invention, pour la sélection de composé organique ou inorganique capable de moduler, de réguler, d'induire ou d'inhiber l'expression de gènes d'une cellule végétale ou animale, ou d'un micro-organisme autre que P. luminescens, dont, par exemple, on veut modifier la résistance ou la sensibilité à au moins une toxine ou antibiotique produit par P. luminescens.

L'invention comprend également une méthode de sélection de composés capables de se lier à un polypeptide ou un de ses fragments selon l'invention, capables de se lier à une séquence nucléotidique selon l'invention, ou capables de reconnaître un anticorps selon l'invention, et/ou capables de moduler, de réguler, d'induire ou d'inhiber l'expression de gènes, et/ou de modifier la croissance ou la réplication cellulaire de cellules eucaryotes ou procaryotes, ou capables d'induire, d'inhiber ou d'accroître chez un organisme animal ou végétal la résistance ou la sensibilité à au moins une toxine ou antibiotique produit par P. luminescens, ladite méthode comprenant les étapes suivantes : a) mise en contact dudit composé avec ledit polypeptide, ladite séquence nucléotidique et/ou avec une cellule transformée selon l'invention ; b) détermination de la capacité dudit composé à se lier avec ledit polypeptide ou ladite séquence nucléotidique, ou de moduler, de réguler, d'induire ou d'inhiber l'expression de gènes, ou de moduler la croissance ou la réplication cellulaire, ou d'induire, d'inhiber ou d'accroître chez un organisme animal ou végétal la résistance ou la sensibilité à au moins une toxine ou antibiotique produit par P. luminescens.

Les cellules transformées selon l'invention, pourront avantageusement servir de modèle et être utilisées dans des procédés pour étudier, identifier et/ou sélectionner des composés susceptibles d'être responsables de la résistance ou la sensibilité à au moins une toxine ou antibiotique produit par P. luminescens. Les composés susceptibles d'être sélectionnés peuvent être des composés organiques tels que des polypeptides ou hydrates de carbone ou tous autres composés organiques ou inorganiques déjà connus, ou des composés organiques nouveaux élaborés à partir de techniques de modélisation moléculaire et obtenus par synthèse chimique ou biochimique, ces techniques étant connues de l'homme de l'art.

L'invention concerne les composés susceptibles d'être sélectionnés par une méthode de sélection selon l'invention.

L'invention concerne également une composition, notamment pesticide ou pharmaceutique, comprenant un composé choisi parmi les composés suivants : a) une séquence nucléotidique selon l'invention ; b) un polypeptide selon l'invention ; c) un vecteur selon l'invention ; d) un anticorps selon l'invention ; et e) un composé susceptible d'être sélectionné par une méthode de sélection selon l'invention, éventuellement en association avec un véhicule pharmaceutiquement acceptable.

L'invention concerne aussi une composition pharmaceutique selon l'invention pour la prévention ou le traitement d'une infection par un micro-organisme, tel qu'une bactérie ou un champignon, sensible à au moins une toxine ou antibiotique produit par P. luminescens.

L'invention concerne aussi une composition pesticide, notamment contre les insectes, bactéries et/ou champignons, selon l'invention, pour la prévention ou le traitement de plantes infectées par des animaux, tels que des insectes, ou par un microorganisme, tel qu'une bactérie ou un champignon, sensible à au moins une toxine ou antibiotique produit par P. luminescens.

L'invention comprend aussi l'utilisation d'une cellule transformée selon l'invention, pour la préparation d'une toxine ou d'un antibiotique produit par P. luminescens.

On entend désigner par véhicule pharmaceutiquement acceptable, un composé ou une combinaison de composés entrant dans une composition pharmaceutique ne provoquant pas de réactions secondaires et qui permet par exemple la facilitation de radministration du composé actif, l'augmentation de sa durée de vie et/ou de son efficacité dans l'organisme, l'augmentation de sa solubilité en solution ou encore l'amélioration de sa conservation. Ces véhicules pharmaceutiquement acceptables sont bien connus et seront adaptés par l'homme de l'art en fonction de la nature et du mode d'administration du composé actif choisi.

De préférence, ces composés pharmaceutiques seront administrés par voie systémique, en particulier par voie intraveineuse, par voie intramusculaire, intradermique ou sous-cutanée, ou par voie orale.

Leurs modes d'administration, posologies et formes galéniques optimaux peuvent être déterminés selon les critères généralement pris en compte dans l'établissement d'un traitement adapté à un patient comme par exemple l'âge ou le poids corporel du patient, la gravité de son état général, la tolérance au traitement et les effets secondaires constatés.

Enfin, l'invention comprend l'utilisation d'une composition selon l'invention, pour la préparation d'un médicament destiné à la prévention ou le traitement d'une infection par un micro-organisme, tel qu'une bactérie ou un champignon, sensible à au moins une toxine ou antibiotique produit par P. luminescens.

Par ailleurs, la présente invention a également pour objet une banque d'ADN génomique d'une bactérie du genre Photorhabdus, de manière préférée, Photorhabdus luminescens, de manière préférée la souche TTOl. Les banques d'ADN génomique décrites dans la présente invention, en particulier la banque BAC déposée à la CNCM le 12 mai 2000 sous le n° 1-2478 et qui recouvre le génome de Photorhabdus luminescens TTOl.

L'invention concerne également un procédé d'identification d'au moins une séquence nucléotidique de P. luminescens non présente dans le génome d'une autre espèce de bactérie, notamment pathogène, et/ou d'identification d'au moins une séquence nucléotidique d'un génome d'une bactérie, notamment pathogène, d'une autre espèce que P. luminescens et non présente dans le génome de P. luminescens, caractérisée en ce qu'elle comprend les étapes suivantes : a) on aligne les séquences nucléotidiques de P. luminescens selon l'invention, ou contenues dans une banque génomique selon l'invention, avec la séquence génomique de l'autre espèce de bactérie, ou l'un de ses fragments ; et b) on traite les données obtenues par cet alignement pour isoler et identifier la ou lesdites séquences uniquement présentes dans l'un ou l'autre génome. Une telle méthode, appelée encore « génomique soustractive » peut être utilisée ici pour identifier une séquence responsable de la pathogénicité d'une bactérie, telle qu'une bactérie gram négative, dont la bactérie P. luminescens, non pathogène, peut servir de modèle de comparaison.

La présente invention concerne ainsi les méthodes pour l'isolement d'un polynucléotide d'intérêt présent chez une souche de Photorhabdus et absente chez une autre souche ou espèce, qui utilise au moins une banque d'ADN basée par exemple sur un plasmide pcDNA2.1 contenant le génome de Photorhabdus. La méthode selon l'invention pour l'isolement d'un polynucléotide d'intérêt peut comprendre les étapes suivantes : a) isoler au moins un polynucléotide contenu dans un clone de la banque d'ADN d'origine de Photorhabdus ; b) isoler :

- au moins un polynucléotide génomique ou ADNc d'une bactérie, ladite bactérie appartenant à une souche ou espèce différente de la souche Photorhabdus utilisée pour la construction de la banque d'ADN de l'étape a) ou, de façon alternative,

- au moins un polynucléotide contenu dans un clone d'une banque d'ADN préparé à partir du génome d'une bactérie appartenant à une souche ou espèce différente de la souche Photorhabdus utilisée pour la construction de la banque d'ADN de l'étape a) et hybrider le polynucléotide de l'étape a) au polynucléotide de l'étape b) ; c) sélectionner les polynucléotides de l'étape a) qui n'ont pas formé de complexe d'hybridation avec les polynucléotides de l'étape b) ; d) caractériser le polynucléotide sélectionné.

On peut préparer le polynucléotide de l'étape a) par la digestion d'au moins un clone recombinant avec une enzyme de restriction appropriée, et de façon optionnelle, l'amplification de l'insert polynucléotide qui en résulte.

Ainsi, la méthode de l'invention permet à l'homme du métier d'effectuer des études génomiques comparatives entre une bactérie du genre Photorhabdus, et entre par exemple une souche ou espèce pathogène.

En particulier, il est possible d'étudier et de déterminer les régions de polymorphisme entre lesdites souches.

La présente invention concerne également l'utilisation des séquences nucléiques ou des polypeptides selon la présente invention :

- pour la préparation de bio-pesticides, notamment d'entomotoxines, d'antibiotiques, d'antifongiques ou de cytotoxines,

- pour la sécrétion de protéines, - comme facteurs de virulence,

- pour le contrôle par l'intermédiaire du quorum-sensing, pour l'identification de cibles pour les maladies humaines dont Photorhabdus luminescens est un modèle (en particulier la peste ou la coqueluche), et

- pour l'identification de cibles contre les bactéries Gram négatives pathogènes par la méthode de génomique sousfractive (comme par exemple par comparaison avec

E. Coli ou d'autres bactéries pathogènes gram négatives).

La présente invention concerne également l'utilisation des polypeptides selon la présente invention pour le criblage de composés capables de moduler l'activité de ces polypeptides, notamment les polypeptides à activité enzymatique. D'autres caractéristiques et avantages de l'invention apparaissent dans les exemples suivants :

EXEMPLES

Exemple 1 ; Matériels et Méthodes La stratégie de séquençage du génome de Photorhabdus luminescens souche TTOl repose sur un séquençage alléatoire (shot-gun). La première étape de ce travail a consisté à cloner l'ADN génomique de la bactérie Photorhabdus luminescens dans différents vecteurs (plasmides et BAC). Banques d'ADN génomique de Photorhabdus luminescens utilisées.

Trois banques d'ADN génomique ont été réalisées :

1) - Une banque d'ADN génomique dans un vecteur bactérien à haut nombre de copies (pcDNA2.1, h vitrogen). Taille moyenne des inserts 1,5 kb. ïï) - Une banque d'ADN génomique dans un vecteur bactérien à faible nombre de copies (pSYX34). Taille moyenne des inserts 10 kb.

ÏÏI) - Une banque d'ADN génomique dans un vecteur BAC (pBeloBACl l, California Institute of Technology). Taille moyenne des inserts 50 à 100 kb.

Deux batchs d'ADN de la souche TTOl de la bactérie Photorhabdus luminescens ont été extraits le 30/10/1998 et le 14/04/1999.

I) Etablissement d'une banque d'ADN génomique dans le vecteur bactérien pcDNA2.1 (Invitrogen)

A) Préparation du vecteur : pcDNA2.1 Nous avons préparé le plasmide pcDNA2.1, en réalisant en parallèle deux midipreps (KIT QIAGEN) selon les conditions préconisées par le fabricant. Le vecteur pcDNA2.1 a été digéré par l'enzyme de restriction BstXl.

B) Préparation de l'ADN chromosomique de Photorhabdus luminescens souche TTOl et ligation dans le vecteur pcDNA2.1 1) Dissolution de l'ADN

Un culot sec d'ADN génomique de la souche TTOl préparé le 30/10/98 a été repris dans 200 μl de TE 10:1 puis dissout 30 min à 65°C. Sa concentration a été estimée à 0,15 μg/μl.

2) Nébulisation de l'ADN 50 μl d'ADN génomique de la souche TTOl dans 2 ml d'H₂O qsp ont été nébulisés durant 45 sec à une pression de 1 bar d'azote, centrifugés 2 min à 600 rpm afin de récupérer la totalité du volume.

3) Précipitation de l'ADN Cet ADN a ensuite été précipité à l'acétate de sodium (2 ml d'ADN + 0,2 ml d'acétate de Na 3M pH 5,2 + 5 ml d'éthanol absolu ; 2 h à - 20°C ; centrifugé à 30 min à 14 000 rpm, 4°C puis redissous dans 100 μl d'eau.

4) Analyse de l'ADN 4 μl ont été déposés sur un gel d'agarose à 1 % en TBE.

Des fragments d'ADN de la taille attendue 500 pdb à 3 kb ont été visualisés.

5) Réparation de l' ADN

Afin de rendre les extrémités des fragments d'ADN franches (blunt end) une réparation à l'aide de la T4 DNA polymérase a été effectuée. Dans 2 tubes séparés on mélange :

- 48 μl d'ADN de l'étape 3), - 100 μl d'H₂O,

- 20 μl de tampon de ligation 5X, - 2 μl de dNTP mix (10 mM), - 5 μl de T4 DNA polymérase (Boehringer).

On incube 25 min à température ambiante puis on arrête la réaction par chauffage 15 min à 75 °C.

6) Précipitation de l'ADN

Cet ADN a ensuite été précipité la nuit à - 20°C à l'acétate de sodium (1/10 du volume d'Acétate de Na et 2,5 volume d'éthanol absolu), centrifugé puis le culot d'ADN obtenu a été séché à l'air et redissout dans 30 μl d'eau.

7) Ligation de l'ADN

Cet ADN a été ligué une nuit à 16°C aux adapteurs Bstx A + Bstx B (Invitrogen) en présence de 2 μl de ligase. 8) Préparation des inserts

Après migration de l'ADN ligué aux adaptateurs dans un gel d'agarose à 1 %, en TAE à 70 Volts, la région d'intérêt (comprise entre 1 et 3 Kb) a été découpée en quatre fragments.

9) Purification des inserts Les fragments d'agarose contenant les régions d'intérêts ont été purifiés par

Geneclean (BIO101) selon les conditions préconisées par le fabricant.

Un aliquot a été déposé sur un minigel d'agarose pour valider la qualité de la purification.

10) Ligation des inserts dans le vecteur pCDNA2.1 (Invitrogen) - 4 μl d'ADN (insert après l'étape de purification Geneclean, étape 9),

- 2 μl de plasmide ρCDNA2.1 (après l'étape de digestion BstXl puis purification Geneclean),

- 2 μl de tampon de ligation (10X), - ajouter 2 μl de ligase,

- 10 μl H₂O (volume total : 20 μl). Incubation une nuit à 16°C. 11) Transformation de cellules ultracompétentes XL2 Blue (Stratagene)

La banque d'ADN génomique obtenue à l'étape 10 a été intégrée dans les cellules ultracompétentes XL2 Blue (Stratagene) selon les conditions préconisées par le fabricant.

L'analyse des inserts de 24 clones par digestion par l'enzyme de restriction Pvuïï et par séquençage des extrémités a été effectuée et a donné des résultats satisfaisants.

II) Etablissement d'une banque d'ADN génomique dans le vecteur bactérien PSYX34

La technique de remplissage partiel (PARTIAL FTLL-IN), développée dans le laboratoire, nous a permis de construire une banque d'ADN génomique de la souche TTOl de la bactérie Photorhabdus luminescens clonée dans le plasmide pSYX34 (taille des inserts environ 10 Kb).

Note : dans ce cas, la digestion par l'enzyme de restriction Sal I, du vecteur pSYX34, libère les extrémités suivantes :

5' TCGAC- G- 5'

Le PARTIAL FÏÏX-IN a été réalisé, en présence des déoxynucléotides dCTP et dTTP.

5' TCGAC- CTG- 5' A) Préparation du vecteur : pSYX34

1) Obtention du vecteur

On a préparé du plasmide pSYX34, en réalisant en parallèle deux midipreps, KIT QIAGEN selon les conditions préconisées par le fabricant.

2) Digestion du plasmide pSYX34 par l'enzyme de restriction Sal I Le volume final sera de 100 μl :

- 20 μl pSYX34,

- 10 μl de tampon H,

- 66 μl d'H₂O, - 4 μl Sal I.

Incubation 2 h à 37°C.

Un aliquot ainsi qu'un marqueur de poids moléculaire ont été déposés sur un minigel d'agarose pour valider la qualité de la purification.

3) Extraction au chloroforme L'extraction au chloroforme permet d'arrêter la digestion enzymatique, et d'éliminer toutes traces protéiques.

Après digestion, on récupère 95 μl,

+ 105 μl TE 10 mM,

+ 200 μl chloroforme. Vortexer, centrifuger 1 min à 1000 rpm.

Récupérer la phase aqueuse (phase supérieure).

4) Précipitation à l'acétate de sodium

- Ajouter 1/10 du volume d'acétate de sodium (3 M, pH : 5,2) soit 20 μl,

- puis 2,5 volumes d'éthanol absolu propre, soit 500 μl (flacon gardé à - 20°C).

Laisser à - 20°C, au moins 1 heure (il est possible de laisser à - 20°C durant la nuit).

- Centrifuger à 4°C (chambre froide) durant 30 min, à 14.000 rpm.

- Eliminer le surnageant à l'aide de la pompe à vide. - Ajouter 400 μl d'éthanol à 70 %, centrifuger à 4°C, 5 min à 14.000 rpm.

- Eliminer le surnageant à l'aide de la pompe à vide, laisser sécher environ une heure sur la paillasse.

- Resuspendre le culot dans 20 μl de TE 10 mM (1/10). 5) Partial fill-in Volume final de la réaction : 50 μl ; 20 μl de ρSYX34 digéré par Sal I

- 5 μl de tampon synthesis,

- 2,5 μl de mix nucléotides (C-T) 1 mM,

- 20,5 μl d'eau, - 2 μl de Kleno (2 U/μl). Laisser 30 min à température ambiante.

Vérification sur minigel d'agarose à 1 % puis congélation à - 20°C. Mélange des nucléotides C-T : mélanger :

- 2 μl de nucléotides T (100 mM),

- 2 μl de nucléotides C (100 mM), - 16 μl de TRIS 10 mM, pH = 7,5.

Les nucléotides sont ainsi dilués au 1/10, pour une concentration de 10 mM. Une seconde dilution au 1/10 dans du tampon TRIS 10 mM, sera réalisée pour avoir une concentration de 1 M.

D'autre part, au cours de la réaction, les nucléotides sont dilués au 1/20 (2,5 μl dans 50 μl), concentration finale ainsi obtenue de 50 μM en nucléotides.

6) Purification du vecteur ρSΥX34 : gel préparatif Préparer un gel d'agarose à 1 %, en TAE, des grands puits seront prévus pour nos échantillons.

Reprendre 30 μl de pGB2 après le partial fill-in (il restera donc 20 μl au congélateur), ajouter 6 μl de solution de dépôt. En parallèle, déposer le marqueur de poids moléculaire dans les proportions suivantes : - 5 μl H₂O,

- 5 μl du marqueur 1 Kb DNA,

- 2 μl de la solution de dépôt. Laisser migrer à 70 Volts.

Découper le gel côté marqueur à l'aide d'un scalpel, et repérer, en prenant une photo et à l'aide d'une règle, la région qui nous intéresse, dans notre cas on prendra la bande correspondant à 4 Kb. Chaque échantillon sera coupé en deux. Le poids de chaque échantillon nous indiquera son volume approximatif.

Nous aurons donc quatre échantillons à purifier par la technique Geneclean ïï.

7) Purification du vecteur pSYX34 - Reprendre dans 3 volumes de solution Iodure de Sodium (1 ml pour un échantillon de 0,2 g), mettre à 49°C, en agitant toutes les 2 min, jusqu'à complète dissolution de l'agarose.

- Ajouter 8 μl de micro-billes : GLASSMILK R, laisser 5-10 min à température ambiante, l'ADN se fixe sur le$ micro-billes. - Centrifuger 2 min à 14.000 rpm, éliminer le surnageant par aspiration.

- Laver 3 fois avec la solution New Wash (600 μl/eppendorf, vortexer, centrifuger quelques secondes à 10.000 rpm), cette solution a été préparée et est gardée à - 20°C. - Resuspendre le culot dans 10 μl d'H₂O, vortexer, laisser 5 min à 49°C. Ceci permet à l'ADN de se décrocher des micro-billes.

- Centrifuger 2 min à 14.000 tpm.

- Récupérer les surnageants dans de nouveaux eppendorfs (N° 1 et N° 2, ...).

- Ajouter à nouveau 10 μl d'H₂O sur les culots, pour être sûr de tout récupérer, vortexer, laisser 2 min à 49°C.

- Centrifuger 2 min à 14.000 rpm.

- Récupérer les surnageants dans les eppendorfs précédents (N° 1 et N° 2, ...).

- Nous avons environ 20 μl de surnageant, centrifuger 2 min à 14.000 rpm.

- Transférer les surnageants dans de nouveaux eppendorfs, de manière à être sûr qu'il ne reste plus de micro-billes.

- Déposer sur un minigel d'agarose à 1 %, 1 μl de chaque préparation (+ 5 μl d'H₂O + 2 μl de solution de dépôt), laisser migrer à 80 volts, 2 heures.

On gardera les échantillons les plus concentrés, ils seront alors congelés à - 20°C. B) Préparation de l'APN chromosomique de Photorhabdus luminescens souche

TTOl

1) Dissolution de l'ADN

Un culot sec d'ADN génomique de la souche TTOl a été repris dans 200 μl de TE 10:1 puis dissous 30min à 65°C. Sa concentration a été estimée à 0,15 μg/μl. 2) Digestion partielle de l'ADN génomique par l'enzyme de restriction Sau3A

15 μl d'ADN ont été digérés par 2 ou 1 ou 0,5 ou 0,25 ou 0,125 ou 0,0625 ou 0,03125 unités d'enzyme de restriction Sau3A pendant 1 h à 37°C. 3) Extraction au chloroforme

L'extraction au chloroforme nous permet d'arrêter la digestion enzymatique, et d'éliminer toutes traces protéiques.

Après digestion, on récupère 100 μl d'ADN chromosomique.

+ 100 μl TE 10 mM

+ 200 μl chloroforme

Vortexer, centrifuger 1 min à 1000 rpm. Récupérer la phase aqueuse, phase supérieure, comportant l'ADN chromosomique.

4) Précipitation à l'acétate de sodium

Ajouter 1/10 du volume, d'acétate de sodium (3M, pH : 5,2) soit 20 μl. Puis 2,5 volumes d'éthanol absolu propre, soit 500 μl (flacon gardé à - 20°C).

Laisser à - 20°C, au moins 1 heure (il est possible de laisser à - 20°C durant la nuit).

Centrifuger à 4°C (chambre froide) durant 30 min, à 14.000 rpm.

Eliminer le surnageant à l'aide de la pompe à vide. Ajouter 400 μl d'éthanol à 70 %, centrifuger à 4°C, 5 min à 14.000 rpm.

Eliminer le surnageant à l'aide de la pompe à vide, laisser sécher environ une heure sur la paillasse.

Resuspendre le culot dans 20 μl H₂O.

5) Vérification des digestions partielles, après précipitation à l'acétate de sodium.

Préparer un gel d'agarose à 1 % en TBE. Déposer 1/10 du volume total des précipitations, soit 2 μl d'ADN + 8 μl d'H₂O + 2 μl de solution de dépôt.

En parallèle, déposer un marqueur de poids moléculaire : 1 μl + 9 μl d'H₂O + 2 μl de solution de dépôt. 6) Partial Fill-in

Volume final de la réaction : environ 50 μl

- 36 μl d'ADN partiellement digéré (ADN digéré par 0,25 ou 0,125 ou 0,0625 ou 0,03125 unités d'enzyme de restriction Sau3A)

- 5 μl de tampon synthesis - 10 μl de mix nucléotides (A-G) ImM => concentration finale : 200 μM

- 2 μl de Klenow (2 U/μl).

Laisser 30 min à température ambiante.

Mélange des nucléotides A-G

Mélanger : - 2 μl de nucléotides A (100 mM)

- 2 μl de nucléotides G (100 mM) - 16 μl de TRIS 10 mM, pH - 7,5.

Les nucléotides sont ainsi dilués au 1/10, on a une concentration delO mM. Une seconde dilution au 1/10 dans H O sera réalisée, on a donc une concentration de 1 mM.

7) Extraction au chloroforme

L'extraction au chloroforme permet d'arrêter la digestion enzymatique, et d'éliminer toutes traces protéiques.

Après digestion, on récupère 53 μl d'ADN chromosomique. + 47 μl TE 10 mM + 100 μl chloroforme Vortexer, centrifuger 1 min à 1000 tpm. Récupérer la phase aqueuse, phase supérieure, comportant l'ADN chromosomique.

8) Précipitation à l'acétate de sodium

Ajouter 1/10 du volume, d'acétate de sodium (3M, pH : 5,2) soit 10 μl.

Puis 2,5 volumes d'éthanol absolu propre, soit 250 μl (flacon gardé à - 20°C). Laisser à - 20°C, au moins 1 heure (il est possible de laisser à - 20°C durant la nuit).

Centrifuger à 4°C (chambre froide) durant 30 min, à 14.000 rpm.

Eliminer le surnageant à l'aide de la pompe à vide.

Ajouter 400 μl d'éthanol à 70 %, centrifuger à 4°C, 5 min à 14.000 rpm. Eliminer le surnageant à l'aide de la pompe à vide, laisser sécher environ une heure sur la paillasse.

Resuspendre le culot dans 20 μl H₂O.

9) Purification de l' ADN chromosomique : Gel préparatif

Préparer un gel d'agarose à 1 %, en TAE, des grands puits seront prévus pour nos échantillons.

Reprendre la totalité d'ADN, soit 20 μl, ajouter 4 μl de solution de dépôt. En parallèle, déposer le marqueur de poids moléculaire dans les proportions suivantes :

- 5 μl H₂O

- 5 μl du marqueur 1 Kb DNA - 2 μl de la solution de dépôt.

Laisser migrer à 70 Volts.

Découper le gel côté marqueur à l'aide d'un scalpel, et repérer, en prenant une photo et à l'aide d'une règle, la région intéressante. Les fragments d'ADN étant longs, on utilisera pour purifier l'ADN, des colonnes SPIN X de chez COSTAR, ceci évitera de couper l'ADN chromosomique.

10) Purification : Colonne SPIN X

Après avoir récupéré les différents morceaux d'agarose, dans les colonnes SPIN X, ajouter 200 μl de TE 10 mM, puis broyer à l'aide d'une spatule.

Ceci pourra être gardé à 4°C. Puis centrifuger 20 min à 5000 rpm. L'agarose sera retenue sur les filtres, alors que l'ADN chromosomique, sera retrouvé au fond du tube.

11) Extraction au chloroforme L'extraction au chloroforme permet d'éliminer toutes traces protéiques.

On récupère 800 μl d'ADN chromosomique.

+ 800 μl chloroforme.

Vortexer, centrifuger 1 min à 1000 rpm.

Récupérer la phase aqueuse, phase supérieure, comportant l'ADN chromosomique.

12) Précipitation à l'acétate de sodium

Ajouter 1/10 du volume, d'acétate de sodium (3 M, pH : 5,2) soit 80 μl.

Puis, 800 μl d'isopropanol.

Laisser à - 20°C, au moins 1 heure (il est possible de laisser à - 20°C durant la nuit).

Centrifuger à 4°C (chambre froide) durant 30 min, à 14.000 rpm.

Eliminer le surnageant à l'aide de la pompe à vide.

Ajouter 400 μl d'éthanol à 70 %, centrifuger à 4°C, 5 min à 14.000 rpm.

Eliminer le surnageant à l'aide de la pompe à vide, laisser sécher environ une demie heure sur la paillasse, et 2 min sous vide.

Resuspendre le culot dans 20 μl TE (0,1 X soit ImM).

Incuber 10 min à 65°C.

Incuber environ 4 heures à 4°C, de manière à ce que l'ADN soit bien resuspendu. Vérification sur minigel d'agarose à 1 %, mettre en parallèle un marqueur de poids moléculaire.

C) Ligation de l'APN chromosomique de Photorhabdus luminescens souche TTOl dans le vecteur pSYX34 Reprendre 6 μl d'ADN chromosomique. Ajouter 2 μl de pSYX34.

Ajouter 2 μl de tampon de ligation (LB : ligation buffer). Ajouter 2 μl de ligase. Puis 8 μl H₂O (volume total : 20 μl).

En parallèle, faire un témoin de ligation, en remplaçant l'ADN chromosomique par du TE O,l X (l mM).

Vortexer, laisser une nuit à 16°C.

Transformation de cellules ultracompétentes XL10-Gold Kanr (Stratagene)

La banque d'ADN génomique obtenue à l'étape précédente a été intégrée dans les cellules ultracompétentes XL10 Gold Kanr (Stratagene) selon les conditions préconisées par le fabricant.

L'analyse des inserts de 24 clones par digestion par l'enzyme de restriction Sali et par séquençage des extrémités a été effectuée et a donné des résultats satisfaisants.

III) Etablissement d'une banque d'ADN génomique dans le vecteur bactérien (pBeloBACll, California Institute of Technology)

Construction de la banque de BAC Digestion partielle de l'ADN dans des morceaux d'agarose :

- les morceaux d'agarose sont lavés trois fois pendant 15 minutes à température ambiante dans une solution de TE (lx) sous agitation modérée ;

- on équilibre les morceaux d'agarose deux fois dans 300 μl d'un tampon de digestion Hind lïï (lx) (Boehringer ou Biolabs) pendant 30 minutes à température ambiante ;

- on enlève le tampon de digestion et on ajoute un tampon de digestion Hind ÏÏI glacé (1 ml par morceau d'agarose) contenant 20 U de Hind LT (Boehringer ou Biolabs) ;

- on incube pendant deux heures dans de la glace ; - on transfert les morceaux d'agarose dans un bain-marie à 37°C et on incube pendant 10 minutes à 30 minutes (en fonction de l'ADN contenu dans les morceaux d'agarose) ; et

- on arrête la digestion par addition de 100 μl d'une solution d'EDTA 250 mM (pH 8). Sélection de la taille :

Séparation de l'ADN partiellement digéré réalisée par PFGE au moyen de l'appareillage CHEF DRTÏÏ (Bio-Rad) :

- gel d'agarose à 1 % LMP dans un tampon Tris-acétate-EDTA (1 x) à 13°C, - inverser le courant chaque 3 à 15 secondes à 6 V/cm pendant 16 heures,

- charger au moins deux morceaux d'agarose et le marqueur,

- colorer le marqueur et une ligne ou une partie de la ligne pour vérifier la digestion partielle,

- exciser les bandes (partie non colorée) de différentes tailles (i.e. de 50 à 100 kb et de 150 à 250 kb),

- les bandes d'agarose peuvent être stockées à 4°C dans une solution de TE. Préparation du vecteur :

- isolement de pBeloBACïï par la méthode au chlorure de césium ;

- digestion par Hind ïï ; - déphosphorilation avec CD³ (éventuellement avec la phosphatase HK).

Ligation et transfonnation :

- les banques d'agarose contenant 1ΑDN sont fondues à 60°C pendant 10 minutes ;

- on équilibre la solution fondue d'agarose/ADN pendant 15 minutes à 45°C ; - on ajoute de la gélase (Epicentre Technologies), à raison d'1 U pour 100 μl de bande de gel (ne pas ajouter de tampon de digestion qui provoque certains problèmes au moment de la ligation) ;

- on effectue la digestion pendant 1 heure à 45 °C ;

- on effectue la ligation dans 50 μl d'une solution contenant pBeloBACïï (2 μl), de la ligase T4 (1 μl à 1:10), un tampon T4 lOx (5μl), et la solution d'ADN/agarose

(42 μl), incubation 20 heures à 16°C ;

- on chauffe le milieu de ligation pendant 15 minutes à 65°C ;

- on dyalise le milieu de ligation contre un tampon Tris-EDTA en utilisant des membranes Millipore de taille de pore VS 0,025 mM ; - 1 ou 2 μl de la solution de ligation sont introduites par électroporation dans les cellules E. coli DH10B (Gibco BRL) en utilisant des cuvettes d'électroporation de largeur 2 mm avec les réglages suivants 2,5 kV, 25 μF et 200 Ω ; - après électroporation on resuspend les cellules dans 600 μl de milieu SOC ou NYZ puis on incube pendant 45 minutes à 37°C sous agitation ;

- on étale 10 et 100 μl de chaque suspension cellulaire dans un milieu agar LB contenant du chloramphénicol (12,5 μg/ml), X-Gal (5-brom-4-chloro-3indolyl-α-D- glucoronic acide ; 50 μg/ml) et de l'IPTG (isopropyl-α-D-thiogalactopyranoside ; 25 μg/ml) ; et

- on incube les boîtes ainsi obtenues pendant la nuit. Extraction de l' ADN plasmidique et séquençage des inserts

L'extraction de l'ADN plasmidique a été effectuée par la technique de lyse alcaline en plaques 24 puits.

Le séquençage des inserts des clones a été effectué par le KIT PE Big Dye selon les conditions préconisées par le fabricant en utilisant les oligonucléotides spécifiques de chaque vecteur.

Les réactions sont ensuite introduites dans le thermocycleur afin de subir 35 cycles composés des trois étapes suivantes :

- dénaturation 10 secondes à 96°C,

- hybridation 10 secondes à 50°C,

- élongation 4 minutes à 56°C.

On réalise ensuite une précipitation à l'éthanol à 76 % durant 20 minutes à température ambiante.

Les plaques sont ensuite centrifugées 35 minutes à 2200 g puis égoutées sur papier absorbant puis centrifugées retournées sur du papier absorbant pendant 1 minute à 500 g afin de ne laisser aucune trace d'éthanol. Les culots d'ADN sont ensuite : - soit repris dans une solution de formamide-EDTA-bleu dextran, puis dénaturés pendant 2 minutes à 96°C. Les plaques sont ensuite immédiatement mises dans la glace, un aliquot étant alors déposé sur gel d'acrylamide d'un séquenceur automatique PE-377,

- soit repris dans une solution d'EDTA 0,3mM ; un aliquot étant alors automatiquement déposé dans un séquenceur automatique PE-3700. Assemblage des séquences obtenues

Les séquences d'ADN génomique ont été assemblées en contig par le logiciel PHRED-PHRAP et visualisées par le logiciel CONSED. Analyse et annotation Les contigs ont tout d'abord été analysés et annotés automatiquement par le logiciel GMPTB.

Exemple 2 : Les gènes d'intérêt Les différentes caractéristiques liées au mode de vie de Photorhabdus luminescens et rapportées dans la littérature (Forst et al., 1997 ; Hu et al., 1998, etc.), ont conduit à rechercher dans le génome de cette bactérie la présence de gènes impliqués dans la biosynthèse d'antibiotiques et de toxines. Les opérons de biosynthèse d'antibiotiques La recherche de peptide-synthé hases a été entreprise in silico. Pour ce faire nous avons utilisé dans un premier temps les différents motifs classiquement décrits dans la littérature (Stachelhaus & Marahiel, 1995, FEMS Microbiology Letters 125:3- 14) comme sonde afin de repérer par homologie de séquence dans le génome de Photorhabdus luminescens, des gènes suceptibles d'être impliqués dans la biosynthèse d'antibiotique.

Modules d'adénylation

1 - LKAGGAYVPÏÏ)

2 - YSGTTGxPKGV

3 - GELCIGGxGxARGYL 4 - YxTGD

5 - VKTRGxRffiLGEIE Module de thioester formation

6 - DNFYxLGGHSL Module de N-méthylation VLE/DxGxGxG

Module de peptide elongation

His- HHILxDGW Module de peptide racemisation (optionnel) His- HfflLxDGW A - AYxTExNDÏÏXTAxG

B - EGHGRExïïE C - RTVGWFTSMYPxxLD D - FNYLGQFD Parmi ces différents modules, certains nous ont permis d'identifier par recherche d'homologie en utilisant le programme BLASTP - Basic local alignment search tool. - (Altschul SF et al., 1990, J. Mol. Biol., 215:403-10) des gènes codant pour des protéines contenant certains de ces motifs. Les gènes ainsi identifiés codant probablement pour des protéines impliquées dans la biosynthèse d'antibiotiques ont été catalogués, et apparaissent notamment dans le tableau I.

On a particulièrement mis l'accent sur les gènes homologues au gène syr E de Pseudomonas syringae ou au gène nosD. Références

- Eric Guenzi, Giuliano Galli, fngeborg Grgurina, Dennis C. Gross, and Guido Grandi, 1998. Characterization of the Syringomycin Synthetase Gène Cluster. A link between prokaryotic and eukaryotic peptide synthetases. J. Biol. Chem., 273:32857-32863.

- Bondi M, Messi P, Sabia C, Baccarani Contri M, Manicardi G., 1999. Antimicrobial properties and morphological characteristics of two Photorhabdus luminescens strains.

New Microbiol., 22: 117-27.

Les opérons de biosynthèse de toxines

Comme pour les gènes de biosynthèse d'antibiotique, nous avons recherché, par homologie de séquence, dans le génome de Photorhabdus luminescens des gènes codant potentiellement pour des protéines toxiques. Nous avons identifié de nombreux gènes codant pour des protéines retenant ces critères. Les entomotoxines (Te loci).

Des homologues au gène Tox A de Clostridium difficile. Des Hémolysines.

Des gènes codant potentiellement pour des protéines homologues aux toxines RTX de Vibrio cholerae.

Des gènes codant potentiellement pour des protéines homologues aux gènes tphA et icmF de Legionella pneumophila (Purcell M, Shuman HA., 1998. The Legionella pneumophila icmGCDÏÏ3F gènes are required for killing of human macrophages. Infect Immun., 66:2245-55).

Voir annotation de ces gènes au tableau I ci-après.

Références - Ffrench-Constant R, Bowen D., 1999. Photorhabdus toxins: novel biological insecticides. Curr Opin Microbiol., 2:284-8. Review.

- Blackburn M, Golubeva E, Bowen D, Ffrench-Constant RH, 1998. A novel insecticidal toxin from Photorhabdus luminescens, toxin complex a (Tca), and its histopathological effects on the midgut of manduca sexta. Appl Environ Microbiol., 64:3036-41.

- Bowen DJ, Ensign JC, 1998. Purification and characterization of a high-molecular- weight insecticidal protein complex produced by the entomopathogenic bacterium Photorhabdus luminescens. Appl Environ Microbiol., 64:3029-35. - Bowen D, Rocheleau TA, Blackburn M, Andreev O, Golubeva E, Bhartia R, ffrench- Constant RH, 1998. Insecticidal toxins from the bacterium Photorhabdus luminescens. Science., 280:2129-32.

- Guo L, Fatig RO 3rd, Orr GL, Schafer BW, Strickland JA, Sukhapinda K, Woodsworth AT, Petell JK, 1999. Photorhabdus luminescens W-14 insecticidal activity consiste of at least two similar but distinct protems. Purification and characterization of toxin A and toxin B. J Biol Chem., 274:9836-42.

Références générales

1. Altschul, S. F., T. L. Madden, A. A. Schaffer, J. Zhang, Z. Zhang, W. Miller, and D. J. Lipman. 1997. Gapped BLAST and PSI-BLAST: a new génération of protein database search programs. [Review] [90 refs]. Nucleic Acids Research. 25:3389-402.

2. Birnboim, H. C. 1983. A rapid alkaline extraction method for the isolation of plasmid DN ^'A. Methods Enzymol. 100:243-255.

3. Braun, L., F. Nato, B. Payrastre, J. C. Mazie, and P. Cossart. 1999. The 213-amino- acid leucine-rich repeat région of the Photorhabdus luminescens InlB protem is sufficient for entry into mammalian cells, stimulation of PI 3-kinase and membrane ruffling. Mol Microbiol. 34:10-23.

4. Buchrieser, C, C. Rusniok, L. Frangeul, E. Couvé, A. Billault, F. Kunst, E. Carniel, and P. Glaser. 1999. The 102 kb locus of Yersinia pestis : séquence analysis and comparison of selected régions among différent Yersinia pestis and Yersinia pseudotuberculosis strains. Infect. Immun. 67:4851-4861.

5. Ewing, B., and P. Green. 1998. Base-calling of automated sequencer traces using phred. ïï. Error probabilities. Génome Res. 8:186-194. 6. Fitch, W. S. 1970. Distingishing homologous from analogous proteins. Syst. Zool. 19:99-113.

7. Frangeul, L., K. E. Nelson, C. Buchrieser, A. Danchin, P. Glaser, and K. F. 1999. Cloning and assembly stratégies in microbial génome projects. Microbiology. 145:2625- 2634.

8. Gordon, D., C. Abajian, and P. Green. 1998. Consed: a graphical tool for séquence finishing. Génome Res. 8:195-202.

9. Jacquet, C, J. Bille, and J. Rocourt. 1992. Typing of Photorhabdus luminescens by retriction polymorphism of the ribonucleic acid gène région. Zentralbl Bakteriol. 276:356-365.

10. Li, P., K. C. Kupfer, C. J. Davies, D. Burbee, G. A. Evans, and H. R. Garner. 1997. PPJMO: A primer design program that applies base quality statistics for automated large-scale DNA sequencing. Genomics. 40:476-485.

11. Lukashin, A. V., and M. Borodovsky. 1998. GeneMark.hmm: new solutions for gène finding. Nucleic Acids Res. 15:1107-1115.

Description scientifique de la banque de BAC de Photorhabdus luminescens souche TTOl déposée à la CNCM le 12 mai 2000 sous le numéro 1-2478

Collection de clones d'Escherichia coli DH 10B™ (Calvin et al., J. Bacteriol. 170, 2796, 1988) contenant des fragments d'ADN génomique de la bactérie

Photorhabdus luminescens souche TTOl, clones dans le vecteur pBelo BACïï (Kim et al, Genomics, 34, 213, 1996) au site Hind lïï. La taille moyenne des inserts est de 60 kb.

Banques de données

On a utilisé des refontes locales de principales banques publiques. La banque de protéines utilisée est constituée par la fusion non redondante de ces banques, telle que la banque Genpept (traduction automatique de GenBank et NCBI).

On a utilisé l'ensemble de logiciel BLAST (domaine public, Altschul et al., 1990) de recherche d'homologies entre une séquence et des banques de données protéiques ou nucléiques. Les seuils de signification utilisés dépendent de la longueur et de la complexité de la région testée ainsi que de la taille de la banque de référence. Ils ont été ajustés et adaptés à chaque analyse. Les résultats de recherche d'homologies entre une séquence selon l'invention et des banques de données protéiques ou nucléiques sont présentés et résumés dans le tableau I et ïï ci-après.

Tableau I

Liste des fonctions putatives (colonne « homology with non-redondant protein data base- description », et colonne « annotations » pour les séquences sélectionnées comme impliquées dans une activité ou à activité de type toxine ou antibiotique) des protéines de séquences SEQ ïï) N° 42 à SEQ ïï) N° 3855 codées par leur séquence nucléotidique respective du génome de Photorhabdus luminescens souche TTOl (génome représenté par les séquences des 41 contigs (SEQ ïï) N° 1 à SEQ ïï) N° 41).

Les séquences nucléiques des protéines de séquence SEQ ) N° 42 à SEQ ïï) N° 3855 peuvent être aisément identifiées par leur position de début (colonne « start ») et de fin (colonne « end ») sur chacune des séquences de contig (colonne « contig »). Légende du tableau I :

L'ensemble des fonctions putatives associées aux protéines de séquence SEQ ï) N° 42 à SEQ ïï) N° 3855 a été obtenu par une recherche d'homologie utilisant notamment logiciel BLASTP (Altschul et al., 1990). Ont été prises en compte notamment les identités significatives, ou la présence de différents motifs (cf. exemples) représentatifs de ces fonctions. La description de la ou les fonctions les plus probables sont données dans la colonne « homology with » et « Annotation ». Tableau II

Liste des fonctions putatives (colonne « fonction obtenue par comparaison sur banque de données » ) des protéines codées par les séquences SEQ ïï) N° 5835 à SEQ ïï⁾ N° 10784 du génome de Photorhabdus luminescens souche TTOl (génome ici représenté par les séquences des 9 contigs (SEQ ïï) N° 5826 à SEQ ïï) N° 5834).

Les séquences nucléiques de séquence séquences SEQ ïï⁾ N° 5835 à SEQ ïï) N° 10784 peuvent être aisément identifiées par leur position de début (colonne « CONTIG », « from ») et de fin (colonne « CONTIG » « to ») sur chacune des séquences de contig Légende du tableau ïï :

L'ensemble des fonctions putatives associées aux protéines codées par les séquences SEQ ïï) N° 5835 à SEQ ïï⁾ N°10784 a été obtenu par une recherche d'homologie utilisant notamment logiciel BLASTP (Altschul et al., 1990). Ont été prises en compte notamment les identités significatives, ou la présence de différents motifs (cf. exemples) représentatifs de ces fonctions. La description de la ou les fonctions les plus probables sont données dans la colonne « homology with » et « Annotation ».

Dans la dernière colonne « HOMOMOGUE A LA SEQUENCE SEQ ïï⁾ », le terme « #N/A » signifie qu »aucune homologie pour la séquence concernée n'avait été identifiée avec l'une des séquences SEQ ïï) Nos. 42 à 3855. Lorsque qu'une séquence homologue a été trouvée parmi les séquences SEQ ï) Nos. 42 à 3855 pour la séquence concernée, celle-ci est mentionnée par son numéro de SEQ ïï) dans cette colonne.

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Identities = 343/609 (56%), Positives = 428/609 (69%), Gaps = 10/609 (1%) sp|P04993|EX5A_ECOLI EXODEOXYRIBONUCLEASE V ALPHA CHAIN

(EXODEOXYRIBONUCLEASE V 67 KDA POLYPEPTIDE) pir||NCECXF exodeoxyribonuclease V (EC 3.1.11.5) 67K chain - Escherichia

SEQ ID n°623 Prot n°PL-1528.1 Contig39 119055 120911 68% coli gb|AAB40466.1| (U29581) exonuclease V alpha-subunit [Escherichia coli] gb|AAC75858.1| (AE000365) DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease [Escherichia coli]

Length = 608

Identities = 435/704 (61%), Positives = 557/704 (78%), Gaps = 1/704 (0%)

SEQ ID n°624 Prot n°PL-1529.1 Contig39 121777 123912 77% gb|AAF85196.1 |AE004049_1 (AE004049) toxin sécrétion ABC transporter ATP binding protein [Xylella fastidiosa] Length = 720

Identities = 151/222 (68%), Positives = 177/222 (79%) sp|P18783|EXBB_ECOLI BIOPOLYMER TRANSPORT EXBB PROTEIN

SEQ ID n°625 Prot n°PL-153.1 Contig41 258461 259522 50% pir||BVECXB biopolymer transport exbB protein - Escherichia coli gb|AAA69173.1 [ (U28377) exbB gène product [Escherichia coli] gb[AAC76042.1 | (AE000383) uptake of enterochelin; tonB-dependent uptake

Identities = 199/467 (42%), Positives = 301/467 (63%), Gaps = 8/467 (1%)

SEQ ID n°626 Prot n°PL-1530.1 Coπtig39 124054 125469 63% gb|AAF85197.1|AE004049_2 (AE004049) hemolysin sécrétion protein D [Xylella fastidiosa] Length = 473

SEQ ID n"627 Prot n°PL-1531.1 Contig39 124834 125538 No Hits found

SEQ ID n"628 Prot n°PL-1533.1 Contig39 133735 134490 No Hits found

Identities = 47/166 (28%), Positives = 67/166 (40%), Gaps = 29/166 (17%)

SEQ ID n°629 Prot n°PL-1534.1 Contig39 134664 135842 17% gb|AAD26911.1|AC006429_1 (AC006429) unknown protein [Arabidopsis thaliana] Length = 291

Identities = 150/522 (28%), Positives = 242/522 (45%), Gaps = 78/522 (14%)

SEQ ID n°630 Prot n°PL-1535.1 Contig39 129589 135981 11% gb|AAB63525.1| (U12682) celfur protein [Caenorhabditis elegans]

Length = 692

Identities = 356/442 (80%), Positives ≈ 397/442 (89%) sp|P08205|ARGA_ECOLI AMINO-ACID ACETYLTRANSFERASE (N-

ACETYLGLUTAMATE SYNTHASE) (AGS) (NAGS) pir||XYECAA amino

SEQ ID n°631 Prot n°PL-1537.1 Contig39 136213 137559 87% acid N-acetyltransferase (EC 2.3.1.1) - Escherichia coli emb|CAA68547.1|

(Y00492) N-acetylglutamate synthase (AA 1 - 443) [Escherichia coli] gb|AAB40465.1| (U29581) N-acetylglutamate synthase [Escherichia coli] gb|AAC75857.1 | (AE000365) N-acetylglutamate synthase; amino acid

Identities = 293/415 (70%), Positives = 351/415 (83%), Gaps = 3/415 (0%)

SEQ ID n°632 Prot n°PL-1538.1 Contig39' 137804 139048 84% sp|Q46929|AMIC_ECOLI N-ACETYLMURAMOYL-L-ALANINE AMIDASE AMIC

PRECURSOR Length = 417

Identities = 242/371 (65%), Positives = 296/371 (79%), Gaps = 2/371 (0%)

SEQ ID n°633 Prot n°PL-1539.1 Contig39 140322 141419 77% gb[AAB40463.1| (U29581) ORF 432 [Escherichia coli] Length = 432

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rυJCi O OBTENUE PAR COMPARAISON SUR BANQUE DE HOMOLOGUE A LA

SEQ ID PROT NB CONTIG SENS % HOMOLOGIE DONNEES (BLAST P) SEQ ID

Contig6 from

SEQ ID-n° 5835 PL-7466.1 m— No—Hits—found

171 to 305 #N/A sp|P39394|YJIW_ECOLI HYPOTHETICAL 14.6 KDA

PROTEIN IN MCRB-HSDS INTERGENIC REGION

(F132) pir| |S56573 hypothetical 14. S protein

Contigδ from (mcrB-hsdS intergenic région) -

SEQ ID n° 5836 PL-7465.1 328 to 570 P 41%

Escherichia coli gb|AAA9724 .l| (U14003)

ORF_fl32 [Escherichia coli] gb |AAC77303.11

(AE000505) orf, hypothetical protein

[Escherichia coli K12] #N/A pir||C69899 conserved hypothetical protein yobL •

Bacillus SUbtiliS gb|AAB8446 .l| (AF027868)

Contig 6 from Topl homolog [Bacillus subtilis]

SEQ ID n° 5837 PL-7463.1 13 1044 to 2099 emb(CAB13792. l| (Z99114) similar to hypothetical proteins from B. subtilis [Bacillus subtilis] #N/A

Contigβ from

SEQ ID n° 5838 PL-7461.1 m No Hits found 2056 to 2148 #N/A Contig6 from

SEQ ID n° 5839 PL-7454.1 m No Hits found 4056 to 4355 #N/A Contig7 from dbj |BAB03228.l| (AB046380) tail fiber protein

SEQ ID n° 5840 PL-3982.3 m 33% 1 to 423 [Pseudomonas aeruginosa] #N/A re |NP_0653 4.1 | 31 pet identical(12 gaps) to sp:Y014_BPHPl [hypothetical 14.9kd

Contig7 from protein of phage HP1] [Escherichia coli]

SEQ ID n° 5841 PL-6900.1 70% 905 to 1333 dbj |BAB12617.l| (AP002527) 31 pet identical(12 gaps) to sp:Y014_BPHPl [hypothetical 14.9kd protein of phage HP1] [Escherichia coli] #N/A

Contig7 from

SEQ ID n° 5842 PL-3201.1 m No Hits found 1784 to 2554 SEQ ID n~2453 gb|AAB49623. lj (U58147) LOS biosynthesis enzyme

Contig7 from

SEQ ID n° 5843 PL-3200.1 m 37% LBGA [Haemophilus ducreyi] gb|AAC45592.1 | 2714 to 3469

(AF004712) LosA [Haemophilus ducreyi] SEQ ID n~2452

TABLEAU II

yjj |ΛΛC38751. l[ (AF030373) galactosyl transferase

Contιg7 from SEQ ID n° 5844 PL-3199.2 ^a m 44? [Streptococcus pneumoniae] gb |AAC6953l. l[

3681 to 4637 (AF057294) Cps23fH [Streptococcus pneumoniae] #N/A

Contig7 from dbj |BAB34316.l| (AP002553) putative enzyme SEQ ID n° 5845 PL-2807.2 m 39'

4749 to 5519 [Escherichia coli 0157:H7] #N/A

pir| |H8ll20 transposase, IS30 family NMB1099

[imported] - Neisseria meningitidis

Contιg7 from SEQ ID n° 5846 PL-2806.1 ³ p 60^ (group B strain MD58) gb|AAF41490.l| (AE002460)

5915 to 6883 transposase, IS30 family [Neisseria meningitidis

MC58] SEQ ID n~2017 gb(AAC69672.l[ (AF019746) putative betal,3-

Contιg7 from SEQ ID n° 5847 PL-2805.1 m 51? glucosyltransferase WaaV [Escherichia

7253 to 8230 coli] SEQ ID n~2016 ref [NP_065324.1 | 31 pet identical(l2 gaps) to s : Y014_BPHP1 [hypothetical 14.9kd

Contxg7 from protein of phage HP1] [Escherichia coli] SEQ ID n° 5848 PL-5321.1 ³ m 59

9075 to 9428 dbj |BAB1 617.1| (AP002527) 31 pet identical(l2 gaps) to sp:Y014_BPHPl [hypothetical

14.9kd protein of phage HP1] [Escherichia coli] #N/A

Contig from dbj |BAA76527.2| (AB017338) tail fiber SEQ ID n° 5849 PL-2804.1 ³ p 32%

9881 to 10684 [Pectobacterium carotovorum] SEQ ID n~2015 ref |NP_050654.l| U [Bacteriophage Mu]

Contig7 from sp | Q9T1U9 | TFA_BPMU PROBABLE TAIL FIBER ASSEMBLY SEQ ID n° 5850 PL-4011.1 10694 to p 54%

PROTEIN (GPU) gb jAAF01128.1 j AF083977_47

11206

(AF083977) U [Bacteriophage Mu] SEQ ID n~3162 pir| |E72354 probable hexosyltransferase (EC

2.4.1.-) TM0622 - Thermotoga maritima

Contig7 from

(Strain MSB8) gb|AAD35706.l| AE001736_4 SEQ ID n° 5851 PL-2803.3 11248 to m 44^s,

(AE001736) lipopolysaccharide biosynthesis

12345 protein, putative [Thermotoga maritima] #N/A

TABLEAU II

sp|P75785|YBIP_ECOLI HYPOTHETICAL 59.7 KDA

PROTEIN IN OMPX-MOEB INTERGENIC REGION pir| (G64818 probable membrane protein ybiP -

Contig? from Escherichia coli gb|AAC7390 .l| (AE000183) SEQ ID n° 5852 PL-2802.2 12438 to 55% putative enzyme [Escherichia coli K12]

13988 dbj JBAA35487.l| (D90718) Hypothetical protein

HI1005 [Escherichia coli] dbj |BAA35497.l|

(D90719) Hypothetical protein HI1005

[Escherichia coli] #N/A

Contig7 from gb|AAG56009.l|AE005333_6 (AΞ005333) putative SEQ ID n° 5853 PL-2801.1 14404^~EcT 533 tail fiber protein f prophage CP-933X

14973 [Escherichia coli 0157 :H7] SEQ ID n~2012 Contig7 from pir[|S18687 Sc/SvN protein - Escherichia coli SEQ ID n° 5854 PL-7063.1 15030 to 37° plasmid pl5B emb|CAA4405O .1 | (X62121) DNA

15758 inversion product [Escherichia coli] #N/A Contig7 from SEQ ID n° 5855 PL-7062.1 16181 to m No Hits found

16300 #N/A pdb|lF3I|A Chain A, Crystal Structure Of Tn5

Contig8 from

SEQ ID n° 5856 PL-7453.1 m 54° Transposase Complexed With Transposon 1 to 189

End Dna #N/A

Contigδ from

SEQ ID n° 5857 PL-7451.1 No Hits found 328 to 594 #N/A ref |χp_046913.l| SWI/SNF related, matrix

Contigδ from

SEQ ID n° 5858 PL-7449.1 143 associated, actin dépendent regulator of 733 to 1521 chromatin, subfamily f, member 1 [Homo sapiens] #N/A pir| |D81221 hypothetical protein NMB0237

[imported] - Neisseria meningitidis

Contig8 from

SEQ ID n° 5859 PL-7448.1 44% (group B strain MD58) gb |AAF40692. l| (AE002381) 1536 to 1883 hypothetical protein [Neisseria meningitidis

MC58] tt-N/A

Contigδ from

SEQ ID n° 5860 PL-7446.1 No Hits found 1966 to 2196 #N/A

TABLEAU II

pιr|[C83640 probable transcription regulator PAO048 [imported] - Pseudomonas

Contigδ from aeruginosa (strain PAOl) _ SEQ ITrn° 5861— L-3392.1 ³ m 3 ?

2236 to 2598 gb|AAG03438.l|AE004444_7 (AE004444) probable transcriptional regulator [Pseudomonas

aeruginosa] SEQ ID n~2627

Contigs from dbj |BAB05094.l| (APO01511) DNA primase [Bacillus

SEQ ID n° 5862 PL-7302.2 20°

2731 to 5193 halodurans] #N/A

Contig9 from dbj |BAB03228.l| (AB046380) tail fiber protein

SEQ ID n° 5863 PL-7272.1 32°

118 to 696 [Pseudomonas aeruginosa] #N/A sp|P77656|YFDK_ECOLI HYPOTHETICAL^" 16.4 KDA

PROTEIN IN INTC-DSDC INTERGENIC REGION pir| [G65008 hypothetical protein b2354 -

Escherichia coli (strain K-12) gb|AAC75413 -l|

Contig9 from (AE000324) orf, hypothetical protein

SEQ ID n° 5864 PL-6899.2 603 699 to 1121 [Escherichia coli K12] dbj |BAA16214.l| (D90865) similar to [SwissProt Accession Number P09154]

[Escherichia coli] dbj |BAA16221.1 [ (D90866) similar to [SwissProt Accession Number P09154]

[Escherichia coli] #N/A gb|AAG56009.l|AΞ005333_6 (AE005333) putative

Contig9 from

SEQ ID n° 5865 PL-3202.1 m 54% tail fiber protein of prophage CP-933X 1166 to 1792

[Escherichia coli 0157 :H7] SEQ ID n~2454 pir| |S18690 Sc/SvQ protein - Escherichia coli

Contιg9 from SEQ ID n° 5866 PL-3983.3 plasmid pl5B emb|CAA44053. l| (X62121) DNA

1792 to 2550 inversion product [Escherichia coli] #N/A

Contig9 from SEQ ID n° 5867 PL-2799.1 ^a m No Hits found

2994 to 3566 SEQ ID n~2008

Contig9 from SEQ ID n° 5868 PL-6821.1 ^M No Hits found

4963 to 5175 #N/A

Contig9 from SEQ ID n° 5869 PL-6822.1 ³ m No Hits found

5256 to 5372 #N/A

TABLEAU II

sp|P76125| DDM_ECOLI HYPOTHETICAL 13.3 KD

PROTEIN IN FDNI-ADHP INTERGENIC REGION

Contig9 from

SEQ ID n° 5870 PL-6823.1 m 66% pir| |H64900 hypothetical protein bl477 - 5679--tcr-B^"969

Escherichia coli gb|AAD13441.l[ (AE000244) orf, hypothetical protein [Escherichia coli K12] #N/A

pir| |JC4693 proteic killer suppression protein hig A - plasmid Rtsl gb|AAC43982.l| (U43847)

Contig9 from

SEQ ID n° 5871 PL-6824.1 m 693 killer protein [Plasmid Rtsl] gb|AAD00515.l| 5969 to 6247 (U81366) killer protein [Plasmid Rtsl] prf | |2210234A higB gène [Escherichia coli] #N/A

Contig9 from

SEQ ID n° 5872 PL-2798.1 m No Hits found 7070 to 8596 SEQ ID n~2007 sp|P44102|YNFI_HAEIN HYPOTHETICAL PROTEIN HI1044 pir| |C64019 ycdY protein homolog HI1044 -

Contig9 from

SEQ ID n° 5873 PL-6825.1 m 533 Haemophilus influenzae (strain Rd 9019 to 9423

K 20) gb|AAC22703.l| (U32785) conserved hypothetical protein [Haemophilus influenzae Rd] #N/A

Contig9 from Sp|P29946|CBIA_SALTY COBYRINIC ACID A, C-DIAMIDE SEQ ID n° 5874 PL-2797.1 10374 to 653 SYNTHASE gb|AAA27252.l| (L12006) precorrin

11756 amidase [Salmonella typhimurium] SEQ ID n~2006 Contig9 from sp | Q05600 | CBIB_SALTY CBIB PROTEIN SEQ ID n° 5875 PL-2796.1 11753 to 753 gb|AAA27253.l| (L12005) putative [Salmonella

12712 typhimurium] SEQ ID n~2005 Contig9 from sp|Q0560l|CBIC_SALTY PRECORRIN-8X METHYLMUTASE SEQ ID n° 5876 PL-2795.1 12727 to 65% (PRECORRIN ISOMERASE) gb [ AA27254.1 | (L12006)

13359 precorrin isomerase [Salmonella typhimurium] SEQ ID n~2004 Contig9 from sp|Q05628|CBID_SALTY CBID PROTEIN SEQ ID n° 5877 PL-2794.1 13356 to 81? gb|AAA27255.l| (L12006) putative [Salmonella

14492 typhimurium] SEQ ID n~2003 sp|Q05629lCBIE_SALTY PRΞCORRIN-6Y C5,15-

Contig9 from METHYLTRANSFERASE [DECARBOXYLATING] (PRECORRIN-6 SEQ ID n° 5878 PL-2793.1 14489 to 653 METHYLTRANSFERASE) (PRECORRIN-6Y METHYLASE)

15091 gb|AAA27256.l| (L12006) precorrin methylase

[Salmonella typhimurium] SEQ ID n~2002

TABLEAU II

Contig9 from _c,_J:,_|V; 5632|CBrr_SALTY PRECORRIN-8 DECARBOXYLASE SEQ ID n° 5879 PL-4012.1 15081 to 793 gb|AAA27257.ι[ (L12006) precorrin decarbocylase _ 15650 [Salmonella typhimurium]_^ SEQ ID n~3163 sp|Q05630|CBIF_SALTY PRECORRIN-4 Cll-

Contig9 from METHYLTRANSFERASE (PRECORRIN-3 METHYLASE) SEQ ID n° 5880 PL-2792.1 15643 to 86%

gb|AAA27258.l| (L12006) precorrin methylase 16416

[Salmonella typhimurium] SEQ ID n~2001

Contig9 from sp|Q0563l|CBIG_SALTY CBIG PROTEIN SEQ ID n° 5881 PL-2791.1 16397 to 713 gb|AAA27259.l| (L12006) putative [Salmonella

17458 typhimurium] SEQ ID n~2 Q 00 sp|Q05590|CBIH_SALTY PRECORRIN-3B C17-

Contig9 from METHYLTRANSFERASE (PRECORRIN-3 SEQ ID n° 5882 PL-2790.1 17452 to 833 METHYLTRANSFERASE) (PRECORRIN-3

18177 METHYLASE) gb |AAA27260.1 | (L12006) precorrin methylase [Salmonella typhimurium] SEQ ID n-1999

Contig9 from sp|Q0559l|CBIJ_SALTY PRΞCORRIN-6X REDUCTASE SEQ ID n° 5883 PL-2789.1 18174 to 673 gb|AAA27261.l| (L12006) GTG start; putative

18959 [Salmonella typhimurium] SEQ ID n-2.997 sp|Q05592|CBIK_SALTY CBIK PROTEIN pdb|lQGθ|A

Contig9 from Chain A, Anaerobic Cobalt Chelatase In Cobalamin SEQ ID n° 5884 PL-2788.1 18973 to 733 Biosynthesis From Salmonella

19767 Typhimurium gb| AA27262.1 | (L12006) putative

[Salmonella typhimurium] SEQ ID n~î996 sp | Q05593 | CBIL_SALTY PRECORRIN-2 C20 -

METHYLTRANSFERASE (S-ADENOSYL-L-

Contig9 from

MΞTHIONINΞ--PRECORRIN-2 METHYLTRAN FERASE) SEQ ID n° 5885 PL-2787.1 19767 to p 73%

(SP2MT) gb|AAA27263. l| (L12006) S-adenosyl-

20480 methionine: precorrin-2 methyltransferase

[Salmonella typhimurium] SEQ ID n~î995

Contig9 from sp|Q05597|CBIP_SALTY COBYRIC ACID SYNTHASE SEQ ID n° 5886 PL-2786.1 20670 to p 76% gb|AAA27268. l| (L12006) cobyric acid synthase

22208 [Salmonella typhimurium] SEQ ID n-2.994 sp|Q05599|COBU_SALTY BIFUNCTIONAL COBALAMIN

Conti 9 from BIOSYNTHESIS PROTEIN COBP [INCLUDES: SEQ ID n° 5887 PL-4013.1 22205 to p 65% COBINAMIDE KINASE; COBINAMIDE PHOSPHATE

22750

GUANYLYLTRANSFERASE] SEQ ID n~3164

TABLEAU II

Contig9 from sp|y05602|COBS_SALTY COBALAMIN [5 ' -PHOSPHATE] SEQ ID n° 5888 PL-2785.1 22747 to 76% SYNTHASE gb]AAA27270.l| (L12006) cobalamin

23493 synthase [Salmonella typhimurium] SE_Q_ID n~î993 sp|Q57089(YBAQ_HAΞIN HYPOTHETICAL PROTEIN HI1251 pir| |H64112 virulence-associated protein vapA

Contig9 from homolog HI1251 - Haemophilus SEQ ID n° 5889 PL-686-1—1 23530 to influenzae (strain Rd KW20) gb | AC22901.1 |

23838

(U32805) virulence associated protein A (vapA)

[Haemophilus influenzae Rd] #N/A

Contig9 from

SEQ ID n° 5890 PL-6832.1 24313 to No Hits found

24663 #N/A

Contig9 from emb|CAB54522.l| (AJ245959) Int protein

SEQ ID n° 5891 PL-6834.1 24679 to 313 [Bacteriophage WPhi]

24903 #N/A

Contig9 from sp | 397011 COBC_SALTY ALPHA-RIBAZOLE-5 ' • PHOSPHATE

SEQ ID n° 5892 PL-2784.1 24944 to 65% PHOSPHATASE

25561 SEQ ID n~S992 sp I P36562 I COBT_ECOLI NICOTINATE-NUCLEOTIDE--

DIMETHYLBENZIMIDAKOLΞ

PHOSPHORIBOSYLTRANSFERASE (NN:DBI PRT)

(Nl-ALPHA-PHOSPHORIBOSYLTRANSFERASE) pir| |F64963 nicotinate-nucleotide-- dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) -

Contig9 from

Escherichia coli dbj |BAA15808.1 | SEQ ID n° 5893 PL-2783.1 25566 to 683

(D90837) Nicotinate-nucleotide- -

26615 dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) (NN:DBI

PRT) (Nl-alpha-

Phosphoribosyltransferase) . [Escherichia coli] gb|AAC75052.l| (AE000291) nicotinate-nucleotide dimethylbenzimidazole-P phophoribosyl transferase [Escherichia coli K12] SEQ ID n~2991

TABLEAU II

Contig9 from gb|AAG54517.l|AE005197_6 (AE005197) Z0248 gène SEQ ID n° 5894 PL-4014.1 27650 to 573 product [Escherichia coli 0157 :H7]

28_129_ SEQ ID n~3165 Contig9 from gb[AAG58551.l|AE005568_l (AE005568) orf; SEQ ID n° 5895 PL-2782.1 28137 to 543 hypothetical protein [Escherichia coli 0157 :H7]

28967 SEQ ID n~î990

Contig9 from SEQ ID n° 5896 PL-2781.1 31272 to No Hits found

31919 SEQ ID n~î989 sp|P19 65|EUTC_SALTY ETHANOLAMINE AMMONIA-LYASE

Contig9_ from LIGHT CHAIN ^~gb^"|AAC78124.1 | (AF093749) SEQ ID n° 5897 PL-2780.1 32013 to 803 ethanolamine ammonia lyase small subunit

32867

[Salmonella typhimurium] SEQ ID n~ï988 sp|P19635|EUTB_ECOLI ETHANOLAMINE AMMONIA-LYASE

HEAVY CHAIN dbj |BAA16323.1 | (D90873)

ETHANOLAMINE AMMONIA-LYASE HEAVY CHAIN (EC

4.3.1.7) (FRAGMENT) . [Escherichia

Contig9 from coli] dbj |BAA16329.l| (D90874) ETHANOLAMINE SEQ ID n° 5898 PL-2779.1 32890 to 93%

AMMONIA-LYASE HEAVY CHAIN (EC 4.3.1.7)

34251

(FRAGMENT) . [Escherichia coli] gb|AAG57559. l|AEO05474_7 (AEO05474) ethanolamine am onia-lyase, heavy chain [Escherichia coli 0157 :H7] SEQ ID n~1986

Contig9 from sp|Q9ZFV2 |EUTA_SALTY ETHANOLAMINE UTILIZATION SEQ ID n° 5899 PL-2778.1 34264 to m 753 PROTEIN EUTA gb | AAC78122.1 | (AF093749) putative

35691 chaperonin [Salmonella typhimurium] SEQ ID n~£985 Contig9 from gb|AAC18603.2] (AF067123) uroporphyrinogen-III C- SEQ ID n° 5900 PL-2777.1 36004 to P 623 methyltransferase [Lactobacillus

36789 reuteri] SEQ ID n~î984 Contig9 from gb|AAC79515.l! (U90625) CobD [Salmonella SEQ ID n° 5901 PL-2776.1 36818 to 693 typhimurium]

37894 SEQ ID n~£983 Contig9 from gb|AAD39022.l| (AF026270) PduX [Salmonella SEQ ID n° 5902 PL-2775.1 37842 to 653 enterica serovar Typhimurium]

38747 SEQ ID n~1982

TABLEAU II

Contig9 from gb|AAG42457.l|AF308467_3 (AF308467) siroheme SEQ ID n° 5903 PL-2774.1 38764 to 68% synthase [Klebsiella aerogenes]

39432 SEQ ID n~î981 sp|P1304θ|BTUR_ECOLI COB(I)ALAMIN

ADENOSYLTRANSFERASE (CORRINOID

ADENOSYLTRANSFERASE) pir||A64875 Cθb(I)alamin adenosyltransferase (EC 2.5.1.17) - Escherichia coli gb|AAA23530.1 | (M21528) btuR protein

[Escherichia coli] dbj |BAA14807. l| (D90764)

Contig9 from

Cob(I)alamin adenosyltransferase (EC 2.5.1.17) SEQ ÇD n° 5904 PL-4015.1 39455 to p 71%

(Corrinoid adenosyltransferase) .

40012

[Escherichia coli] dbj |BAA1482 . l| (D90765)

Cob(l)alamin adenosyltransferase (EC 2.5.1.17)

(Corrinoid adenosyltransferase) .

[Escherichia coli] gb|AAC74352.l| (AΞ000225) cob(I)alamin adenolsyltransferase [Escherichia coli K12] SEQ ID n~3166

Contig9 from gb|AAG58749.l|AE005587_7 (AE005587) putative SEQ ID n° 5905 PL-2773.1 40918 to p 42% adhesin [Escherichia coli 0157 :H7]

41556 SEQ ID n~î980 Contig9 from dbj |BAA76527. | (AB017338) tail fiber SEQ ID n° 5906 PL-2772.2 42742 to p 35% [Pectobacterium carotovorum]

44226 SEQ ID n~3>979 Contig9 from dbj |BAA76527.2| (AB017338) tail fiber SEQ ID n° 5907 PL-3162.1 44309 to p 22% [Pectobacterium carotovorum]

45724 SEQ ID n~2409 Contig9 from gb|AAG54576.l|AE005203_5 (AE005203) unknown SEQ ID n° 5908 PL-3163.1 46168 to p 23% protein from prophage CP-933H [Escherichia coli

46932 0157:H7] SEQ ID n~2410 Contig9 from gb|AAG54576.l|AE005203_5 (AE005203) unknown SEQ ID n° 5909 PL-3164.1 47466 to p 25% protein from prophage CP-933H [Escherichia

48053 coli 0157 :H7] SEQ ID n~2411 ref |NP_050998.l| P37 [Bacteriophage APSE-1]

Contig9 from sp | Q9T1R1 | FA_BPAPS PROBABLE TAIL FIBER ASSEMBLY SEQ ID n° 5910 PL-4016.1 48056 to p 57%

PROTEIN (P37) gb | AAF03980.1 |AF157835_37

48478

(AF157835) P37 [Bacteriophage APSE-1] SEQ ID n~3167

TABLEAU II

Contig9 from gD|AAG54576.l|AE005203_5 (AΞ005203) unknown

SEQ ID n° 5911 PL-3165.1 49182 to 24% protein from prophage CP-933H [Escherichia coli 50087 0157 :H7] SEQ ID n~2412 ref |NP_050998.l| P37 [Bacteriophage APSE-1]

Contig9 from s | Q9T1R1 | TFA_BPAPS PROBABLE TAIL FIBER ASSEMBLY

SEQ ID n° 5912 PL-6840.1 50100 to 603

PROTEIN (P37) gb | AF03980.1 | AF157835_37 50522

(AF157835) P37 [Bacteriophage APSE-1] #N/A

Contig9 from

SEQ ID n° 5913 PL-6841.1 50754 to m No Hits found

50918 #N/A

Contig9 from dbj |BAB06239.1j (AP001515) transposase related

SEQ ID n° 5914 PL-3166.1 51105 to P 213 protein (20) [Bacillus halodurans]

52130 SEQ ID n~2413

Contig9 from gb|AAF23801.l|AF213822_16 (AF213822) unknown

SEQ ID n° 5915 PL-6913.1 52127 to 373 protein [Zymomonas mobilis]

52531 #N/A

Contig9 from gb|AAG55918.l(AE005325_ll (AΞ005325) putative

SEQ ID n° 5916 PL-3167.1 52845 to 613 antirepressor protein encoded by prophage

53660 CP-933N [Escherichia coli 0157 :H7] SEQ ID n~2414

Contig9 from

SEQ ID n° 5917 PL-6845.1 53775 to No Hits found

54071 #N/A

Contig9 from

SEQ ID n° 5918 PL-6846.1 54086 to p No Hits found

54217 #N/A

Contig9 from

SEQ ID n° 5919 PL-6847.1 54263 to No Hits found

54373 #N/A

Contig9 from gb|AAG56009.l|AE005333_6 (AE005333) putative

SEQ ID n° 5920 PL-6848.1 54424 to p 463 tail fiber protein of prophage CP-933X

54606 [Escherichia coli 0157 :H7] #N/A

Contig9 from dbj |BAA75916.1 | (AB024602) similar to integrase

SEQ ID n° 5921 PL-3168.1 54872 to 443 [Pseudomonas putida]

56050 SEQ ID n~2415

TABLEAU II

Contig9 from SEQ ID n° 5922 PL-6849.1 56052 to m No Hits found

56270 #N/A Contig9 from SEQ ID n° 5923 PL-6852.1 5

Contig9 from gb|AAF72345.l|AF192329_6 (AF192329) Munl-like SEQ ID n° 5924 PL-3169.1 57374 to m 493 protein [Enterococcus faecalis]

58018 SEQ ID n~2416 Contig9 from SEQ ID n° 5925 PL-6854.1 58295 to ^~ ttf No Hits found

58525 #N/A Contig9 from SEQ ID n° 5926 PL-3170.1 58682 to m No Hits found

59338 SEQ ID n~2418 Contig9 from SEQ ID n° 5927 PL-6855.1 59344 to _ No Hits found

59781 #N/A Contig9 from SEQ ID n° 5928 PL-6856.1 59797 to No Hits found

59976 #N/A ref |NP_050511.l| hypothetical protein

Contig9 from [Bacteriophage VT2-Sa] dbj |BAA84295.l| SEQ ID n° 5929 PL-6857.1 59989 to 20% (APO 00363) hypothetical protein [Bacteriophage

60396 VT2-Sa] dbj |BAA94111.l| (AP000422) hypothetical protein [Escherichia coli 0157 :H7] #N/A pdb|lAVQ[A Chain A, Toroidal Structure Of Lambda

Exonuclease Determined At 2.4

Contig9 from Angstroms pdb | 1AVQ | B Chain B , Toroidal SEQ ID n° 5930 PL-3171.1 60387 to 823 Structure Of Lambda Exonuclease Determined At

61070 2.4 Angstroms pd | 1AVQ | C Chain C,

Toroidal Structure Of Lambda Exonuclease

Determined At 2.4 Angstroms SEQ ID n~2419

TABLEAU II

xei |NP_049474.l] Bet protein [Bacteriophage

Con SEQ ID n° 5931 PL-3172.1 6

bacteriophage BP-933 [Escherichia coli 0157 :H7] SEQ ID n~2420

Contig9 from SEQ ID n° 5932 PL-6859.1 61988 to m No Hits found

62245 #N/A Contig9 from ref |NP_0 1549.1 | Orf53 [Pseudomonas phage D3] SEQ ID n° 5933 PL-3173.1 62636 to m 58! gb|AAF80812.l| (AF165214) 0rf53 [Pseudomonas

63538 phage D3] SEQ ID n~2421 Contig9 from SEQ ID n° 5934 PL-6860.1 63608 to m No Hits found

64030 #N/A gb|AAG56433.l|AΞ005370_6 (AE005370) unknown

Contig9 from protein encoded within prophage CP-933R SEQ ID n° 5935 PL-6861.2 64060 to 63% [Escherichia coli 0157 :H7 EDL933]

64317 dbj |BAB35373.1] (AP002556) hypothetical protein

[Escherichia coli 0157 :H7] #N/A

Contig9 from SEQ ID n° 5936 PL-7067.1 64536 to m No Hits found

64715 #N/A Contig9 from emb|CAB38995.l| (AL034558) predicted using SEQ ID n° 5937 PL-7068.1 64792 to m 43% hexExon; MAL3P2.8 (PFC0195w) , Hypothetical

65322 protein, len: 1424 aa [Plasmodium falciparum] #N/A sp|P18683 |VNUN__BPHK0 TRANSCRIPTION TERMINATION

Contig9 from

FACTOR NUN pir | |VNBPHK regulatory protein nun - SEQ ID n° 5938 PL-7069.1 65429 to 45% phage HK022 emb| CAA34221. ι| (X16093) nun gène

65635 product (AA 1-112) [Enterobacteria phage HK022] #N/A

Contig9 from SEQ ID n° 5939 PL-7070.2 65727 to m No Hits found

66011 #N/A

TABLEAU II

Contig9 from SEQ ID n° 5940 PL-7071.2 66201 to m No Hits found

66419 #N/A Contig9 from SEQ ID n° 5941 PL-7264.1 6

Contig9 £rôπT gb|AAG572 3.l|AEÔ0544 _ll (AE005443) unknown SEQ ID n° 5942 PL-7263.1 66747 to 46% protein encoded within prophage CP-933V

67157 [Escherichia coli 0157 :H7 EDL933] #N/A ref |NP_049485.1 | repressor protein CI

[Bacteriophage 933W] gb| AD25430.1 | AF125520_25

Contig9 from (AF125520) repressor protein CI [Bacteriophage SEQ ID n° 5943 PL-1036.2 67551 to m 583 933 ] gb[AAG55574.l(AE005295_14 (AE005295)

68189 putative repressor protein CI of bacteriophage

BP-933W [Escherichia coli 0157 :H7

EDL933] #N/A sp|P03036|RCRO_BP434 REGULATORY PROTEIN CRO

(ANTIREPRESSOR) pir| |RCBP4 regulatory protein cro - phage 434 pdb|lzUG| Structure Of Phage

434 Cro Protein, Nmr, 20 Structures pdb|3CRθ|L

Chain L, 434 Cro Protein Complex With 20 Base

Contig9 from

Pair Pièce Of DNA Containing Operator

SEQ ID n° 5944 PL-4634.1 68299 to 683

OR1 pdb|2CR0| 434 Cro Protein pdb|3CRθ|R

68502

Chain R, 434 cro Protein Complex With 20 Base

Pair Pièce Of DNA Containing Operator

0R1 emb|CAA23908.l| (V00635) reading frame

(cro) [Bacteriophage 434] gb| AA32245.1 |

(J02460) cro [bacteriophage lambda] #N/A

Contig9 from gb| AAB22480.1 | transcription activator protein

SEQ ID n° 5945 PL-4633.1 68625 to 423 Cl, P22 Cl [bacteriophage P22,

68942 Peptide, 92 aa] #N/A

Contig9 from

SEQ ID n° 5946 PL-4632.1 68987 to No Hits found

69349 ff-N/A

TABLEAU II

Contig9 from SEQ ID n° 5947 PL-3857.1 69763 to No Hits found 70044 SEQ ID n~S029

Contig9 from emb|CAC04160.l| (AJ292531) putative helicase SEQ ID n° 5948 PL-1037.1 70116 to 363

[Lactococcus bacteriophage phi31] 71657 SEQ ID n~8

Contig9 from gb|AAG54598.l|AE005204_8 (AE005204) alpha SEQ ID n° 5949 PL-1038.1 71812 to 343 réplication protein of prophage CP-933I

72576 [Escherichia coli 0157 :H7] SEQ ID n~85 Contig9 from SEQ ID n° 5950 PL-4628.1 72629 to No Hits found

72781 #N/A sp|Q37870|YBCN_BP82 HYPOTHETICAL 17.5 KDA

Contig9 from PROTEIN IN RUSA 5'REGION (ORF151) pir||S66580 SEQ ID n° 5951 PL-4627.1 72989 to 60% hypothetical protein ybcN - phage 82

73432 emb|CAA63327.l| (X92588) orf151 [Bacteriophage

82] #N/A

Contig9 from SEQ ID n° 5952 PL-4626.1 73432 to No Hits found

73668 #N/A ref |NP_047915.l| unknown [Yersinia pestis] pir||τi5030 hypothetical protein Y1115 -

Contig9 from

Yersinia pestis plasmid pMTl gb |AAC82773.1 | SEQ ID n° 5953 PL-4625.1 73777 to 48%

(AF074611) unknown [Yersinia pestis]

74157 emb[CAB55230.l| (AL117211) hypothetical protein

YPMT1.48C [Yersinia pestis] #N/A

Contig9 from pir| |B64911 hypothetical protein bl559 - SEQ ID n° 5954 PL-1039.1 74526 to 533 Escherichia coli gb|AAC74632.l| (AΞ000253) orf,

75341 hypothetical protein [Escherichia coli K12] SEQ ID n~86 Contig9 from SEQ ID n° 5955 PL-3856.1 75579 to No Hits found

75989 SEQ ID n~3028

TABLEAU II

_ûfc,|P76195|YDIH_ECOLI HYPOTHETICAL 10.5 KD

PROTEIN IN LPP-AROD INTERGENIC REGION

Contig9 from pir| |E64926 hypothetical protein bl685 - SEQ ID n° 5956 PL-462Î.1 76213 to m 463 Escherichia coli gb| AAC74755.l| (AE000263) orf/

76398 hypothetical protein [Escherichia coli K12]

gb|AAG56672.l|AΞ005391_9 (AE005391) orf, hypothetical^* protein [Escherichia coli 0157 :H7] ^~#N75^"

Contig9 from

SEQ ID n° 5957 PL-4620.1 76370 to m No Hits found

76468 #N/A

Contig9 from emb|CAB58444.l( (AJ133022) hypothetical protein

SEQ ID n° 5958 PL-4619.1 76550 to 643 [Xenorhabdus nematophilus]

76873 #N/A ref |NP_049909.l| structural protein P5

Contig9 from

[Alteromonas phage PM2]

SEQ ID n° 5959 PL-4618.1 76870 to 583 gb|AAD43555.l|AF155037_18 (AF155037) structural

77280 protein P5 [Alteromonas phage PM2] #N/A

Contig9 from

SEQ ID n° 5960 PL-4617.1 77292 to No Hits found

77516 #N/A

Contig9 from gb|AAB40752.l| (U82598) hypothetical protein

SEQ ID n° 5961 PL-3855.1 77513 to 463 [Escherichia coli]

77962 SEQ ID n~3027

Contig9 from ref |NP_065305.l| yajA [Escherichia coli]

SEQ ID n° 5962 PL-4616.1 78159 to m 433 dbj |BAB12598.l| (AP002527) yajA [Escherichia

78437 coli] #N/A

Contig9 from

SEQ ID n° 5963 PL-1040.1 79085 tO No Hits found

79753 SEQ ID n~88 ref |NP_050978.l| P17 [Bacteriophage APSE-1]

Contig9 from sp|Q9TlTl|VP17_BPAPS PUTATIVE PROTEIN P17

SEQ ID n» 5964 PL-4614.1 79798 to 60% gb|AAF03960.l|AF157835_17 (AF157835) P17

80199

[Bacteriophage APSE-1] #N/A

Contig9 from ref |NP_050979.l| P18 [Bacteriophage APSE-1]

SEQ ID n° 5965 PL-1041.1 80196 to 233 gb|AAF03961.l|AF157835_18 (AF157835) P18

81425 [Bacteriophage APSE-1] SEQ ID n~89

TABLEAU II

sp|f<-4183 [YE09_HAEIN HYPOTHETICAL PROTEIN HI1409

Con SEQ ID n° 5966 PL-1042.1 8

influenzae Rd] SEQ ID n~90 pir| |E82650 plasmid-related protein XF1679 XF1574 [imported] - Xylella

Contig9 from fastidiosa (strain 9a5c) SEQ ID n° 5967 PL-1043.1 82758 to 483 gb|AAF84383.l|AE003986_13 (AE003986) plasmid-

8357Cf ^~ related protein [Xylella fastidiosa] gb|AAF84488.l|AE003993_7 (AE003993) plasmid- related protein [Xylella fastidiosa] SEQ ID n~91 sp|P44180|YE05_HAEIN HYPOTHETICAL PROTEIN HI1405 pir| |A64028 hypothetical protein HI1405 -

Contig9 from Haemophilus influenzae (strain Rd SEQ ID n° 5968 PL-1044.1 83574 to 483 KW20) gb|AAC23055.l| (U32820) H. influenzae

84731 predicted coding région HI1405 [Haemophilus influenzae Rd] SEQ ID n~92

Contig9 from SEQ ID n° 5969 PL-3854.1 84734 to p No Hits found

85219 SEQ ID n~3026 Contig9 from SEQ ID n° 5970 PL-1045.1 85224 to No Hits found

86183 SEQ ID n~93 pir| |A82665 hypothetical protein XF1579 XF1684

[imported] - Xylella fastidiosa

Contig9 from (strain 9a5c) gb|AAF84388.l| AE003986_18 SEQ ID n° 5971 PL-4610.1 86198 to P 493 (AΞÛ03986) hypothetical protein [Xylella

86560 fastidiosa] gb|AAF84493.l|AE003993_12

(AE003993) hypothetical protein [Xylella fastidiosa] #N/A

TABLEAU II

_JJJ.O. _| ,C82651 hypothetical protein XF1685 XF1580

[imported] - Xylella fastidiosa Contig9 from (strain 9a5c) gb| AF84389.l| AE003986_19 _

SEQ ID n° 5972 PL-1046.1 86557 to 423 (AΞ003986) hypothetical protein [Xylella

87150 fastidiosa] gb | AAF8449 .1 |AE003993_13

(AEO 03993) hypothetical protein [Xylella fastidiosa] SEQ ID n~94 pir||C82665 hypothetical protein XF1581 XF1686

[imported] - Xylella fastidiosa

Contig9 from (strain 9a5c) gb|AAF84390.l|AE003986_20

SEQ ID n° 5973 PL-4609.1 87131 to 47% (AE003986) hypothetical protein [Xylella

87481 fastidiosa] gb | AF84495.1 | AE003993_14

(AE003993) hypothetical protein [Xylella fastidiosa] #N/A pir| |E82651 hypothetical protein XF1687 XF1582

[imported] - Xylella fastidiosa

Contig9 from (strain 9a5c) gb | AAF84391.1 | AE003986_21 SEQ ID n° 5974 PL-3853.1 87468 to 393 (AE003986) hypothetical protein [Xylella

87899 fastidiosa] gb | AF84496.1 | AE003993_15

(AE003993) hypothetical protein [Xylella fastidiosa] SEQ ID n~30. pir||F82651 hypothetical protein XF1688 XF1583

[imported] - Xylella fastidiosa

Contig9 from (strain 9a5c) gb| AAF84392.l| AE003986_22

SEQ ID n° 5975 PL-1047.1 87902 to 563 (AEO03986) hypothetical protein [Xylella

89413 fastidiosa] gb | AAF84497.1 |AΞ003993_16

(AE003993) hypothetical protein [Xylella fastidiosa] SEQ ID n~95 pir||F82665 hypothetical protein XF1584 XF1689

[imported] - Xylella fastidiosa

Contig from (strain 9a5c) gb| AAF84393.1 [ AE003986_23 SEQ ID n° 5976 PL-4608.1 89423 to 523 (AΞ003986) hypothetical protein [Xylella

89851 fastidiosa] gb |AAF84498.1 | AE003993_17

(AE003993) hypothetical protein [Xylella fastidiosa] #N/A

TABLEAU II

ι ,H82651 hypothetical protein XF1690 XF1585

[imported] - Xylella fastidiosa

Contig9 from (strain 9a5c) _gb|AAF84394.1 | AE003986_24 SEQ ID n° 5977 PL-4607.1 8985x^~tO 473 (AE003986) hypothetical protein [Xylella

90246 fastidiosa] gb | AAF84499.1 | E003993_18

(AE003993) hypothetical protein [Xylella fastidiosa] #N/A^~

Contig9 from SEQ ID n° 5978 PL-4606.1 90282 to No Hits found

90419 #N/A pir| |B82652 hypothetical protein XF1692

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 5979 PL-1048.1 90394 to 31% (Strain 9a5c) gb| AF84501. | AE003993_20

92382 (AΞ003993) hypothetical protein [Xylella fastidiosa] SEQ ID n~96

Contig9 from SEQ ID n° 5980 PL-4605.1 92451 to No Hits found

92738 #N/A pir| |D83221 hypothetical protein PA3385

[imported] - Pseudomonas aeruginosa

Contig9 from

(strain PA01) gb | AAD55364.1 | (AF139988) DNA SEQ ID n° 5981 PL-4604.1 92756 to m 293 bindin -protein; AlgZ [Pseudomonas aeruginosa]

93031 gb|AAG06773. l| AE004760_1 (AE004760) hypothetical protein [Pseudomonas aeruginosa] #N/A

Contig9 from SEQ ID n° 5982 PL-4603.1 93142 to No Hits found

93315 #N/A ref |NP_050ll5.l | hypothetical protein

Contig9 from

[Lactobacillus bacteriophage phi adh] SEQ ID n° 5983 PL-1049.1 93302 to 17% emb|CAB52485. l| (AJ131519) hypothetical protein

94246

[Lactobacillus bacteriophage phi adh] SEQ ID n~97

Contig9 from gb|AAG55887.l|AE005323_3 (AE005323) putative Gef SEQ ID n° 5984 PL-4602.1 94427 to P 69% like protein encoded by prophage CP-933N

94633 [Escherichia coli 0157 :H7] #N/A

o o «H (H 1 ! ! ! α β a α Ci p Q p =8= P

H H n

H H H α σ σ σ w m W M m

W w ω

A" n O

-ni U)

H H H H H

TABLEAU II

Contig9 from pιr||si8687 Sc/SvN protein - Escherichia coli

SEQ ID n° 5992 PL-1055.1 99412 to 19 plasmid pl5B emb|CAA44050.l| (X62121) DNA

100734 inversion product [Escherichia coli] SEQ ID n~3L04

Contig9 from gb|AAG56009.l|AE005333_6 (AE005333) putative

SEQ ID n° 5993 PL-1056.1 100734 to 47% tail fiber protein of prophage CP-933X

101360 _ _ _ _ [Escherichia coli 0157 :H7] SEQ ID n~SL05 sp|P33922|YEJM_ECOLI HYPOTHETICAL 67.3 KD

PROTEIN IN RPLY-PROL INTERGENIC REGION pir| |C64988 hypothetical 67.3 kD protein in rplY

Contig9 from proL intergenic région - Escherichia SEQ ID n° 5994 PL-1057.1 101676 to m 73° coli (strain K-12) gb|AAA16384.l| (U00008) yejM

103415 [Escherichia coli] gb|AAC75249.l| (AE000308) putative sulfatase [Escherichia coli K12] gb|AAG57326.l|AE005451_7 (AE005451) putative sulfatase [Escherichia coli 0157 :H7] SEQ ID n-2.06 sp|P3392l|YEJL_ECOLI HYPOTHETICAL 8.3 KD PROTEIN

IN RPLY-PROL INTERGENIC REGION pir| |B64988 hypothetical 8.3 kD protein in rplY-proL

Contig9 from intergenic région - Escherichia coli SEQ ID n° 5995 PL-4598.1 103448 to 84% (strain K-12) gb |AAA16383. l| (U00008) yejL

103675 [Escherichia coli] gb|AAC75248.l| (AE000308) orf, hypothetical protein [Escherichia coli K12] gb|AAG57325.l|AΞ005451_6 (AE005451) orf, hypothetical protein [Escherichia coli 0157 :H7] #N/A sp|P33920| A37_ECOLI 37 KD NUCLEOID-ASSOCIATED

PROTEIN pir| |A64988 hypothetical 37.8 kD

Contig9 from protein in rplY-proL intergenic région -

SEQ ID n° 5996 PL-1058.1 103947 to 863 Escherichia coli (strain K-12) gb| AA16382.1 |

104951 (U00008) yejK [Escherichia coli] gb| AAC75247. l|

(AE000308) orf, hypothetical protein

[Escherichia coli K12] SEQ ID n~£07 pdb|487D|N Chain N, Seven Ribosomal Proteins

Contig9 from

Fitted To A Cryo-Electron Microscopic

SEQ ID n° 5997 PL-4597.1 105024 to m 85%

Map Of The Large 50s Subunit At 7.5

105308

Angstroms Resolution #N/A

TABLEAU II

Contig9 from gû|AAG57322.l|AE005451_3 (AE005451) putative ATP-

SEQ ID n° 5998 PL-1059.1 105467 to 79% dependent helicase [Escherichia coli

107224 0157 :H7] SEQ ID n-î.08 sp|P33918|RSUA_ECOLI RIBOSOMAL SMALL SUBUNIT PSEUDOURIDINE SYNTHASE A (16S PSEUDOURIDYLATE 516 SYNTHASE) (16S PSEUDOURIDINE

516 SY TH SETH;URACIL HYDROLYASE) pir| |F64987 hypothetical 25.9 kD protein in bcr- rplY intergenic région - Escherichia coli (strain K-12) gb|AAA16377.1 | (U00008) yejD

Contig9—from

[Escherichia coli] gb| AAB34905.1 | 16S RNA

SEQ ID n° 5999 PL-1060.1 107514 to 79% pseudouridine 516 synthase, 16S RNA psi 516

108215 synthase=rsuA gène product

[Escherichia coli, Peptide, 231 aa] gb|AAC75244.l| (AE000308) 16S pseudouridylate

516 synthase [Escherichia coli K12] gb|AAG57321.l|AE005451_2 (AE005451) 16S pseudouridylate 516 synthase [Escherichia coli

0157:H7] SEQ ID n~110

Contig9 from gb|AAG57320.l|AE005451_l (AE005451) bicyclomycin

SEQ ID n° 6000 PL-1061.1 108259 to 773 résistance protein; transmembrane protein

109443 [Escherichia coli 0157:H7] SEQ ID n~5.ll sp|P33917|YEJG_ECOLI HYPOTHETICAL 12.5 KD

PROTEIN IN RTN-BCR INTERGENIC REGION

Contig9 from pir| |D64987 hypothetical 12.5 kD protein in bcr

SEQ ID n° 6001 PL-4596.1 110543 to 713 5 ' région - Escherichia coli (strain K-

110887 12) gb|AAA16380.l| (U00008) yejG [Escherichia coli] gb|AAC75242.l| (AE000307) orf, hypothetical protein [Escherichia coli K12] #N/A

TABLEAU II

sp| i-77685 |SPR_EC0LI LIPOPROTEIN SPR PRECURSOR pir||F64986 hypothetical protein b2175 -

Escherichia coli (strain K-12) dbj |BAA1 140. l|

(D86610) Spr [Escherichia coli] dbj |BAA15983.1 |

Contig9 from

(D90849) Probable lipoprotein NlpC homolog SEQ ID n° 6002 PL-1062.1 111099 to 743 precursor. [Escherichia coli]__

111689 gb|AAC75236.l| (AE000307) putative lipoprotein

[Escherichia coli K12] gb| AAG57313.1 | AE005450_3

(AE005450) putative lipoprotein [Escherichia coli 0157 :H7] SEQ ID n~212 pir| |E64986 hypothetical protëιhT52174 -

Escherichia coli (strain κ-12) gb|AAC75235.l|

Contig9 from

(AΞ000307) orf, hypothetical protein SEQ ID n° 6003 PL-1063.1 112038 to 703

[Escherichia coli K12] gb| AG57312. l| E005450_2

112742

(AE005450) orf, hypothetical protein

[Escherichia coli 0157.-H7] SEQ ID n~213

Contig9 from SEQ ID n° 6004 PL-4595.1 113181 to No Hits found

113492 #N/A Contig9 from gb|AAG57309.l|AE005449_7 (AE005449) putative SEQ ID n° 6005 PL-1064.1 113843 to m 853 elongation factor [Escherichia coli 0157 :H7]

114415 SEQ ID n~îl4 pir| |E82966 tryptophan permease PA5434

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 6006 PL-1065.1 114548 to m 643 (strain PAOl) gb|AAG08819.l|AE004956_3

115807 (AE004956) tryptophan permease [Pseudomonas aeruginosa] SEQ ID n~∑15

Contig9 from gb|AAG52038.l|AC011914_8 (AC011914) putative SEQ ID n° 6007 PL-4594.1 115923 to m 47% mutT protein; 68398-67881 [Arabidopsis

116342 thaliana] #N/A

2/094867 439

H co e»

H H

TABLEAU II

sp|P32 84|YEIE_ECOLI HYPOTHETICAL

TRANSCRIPTIONAL REGULATOR IN LYSP-NFO INTERGENIC

REGION pir| |D64984 hypothetical transcription regulator lysP-nfo intergenic région -

Escherichia coli (strain K-12) gb|AAA60508.l|

Contig9 from (U00007) yeiE [Escherichia coli] gb|AAA1705 . l[ SEQ ID n° 6011 PL-1069.1 119742 to P 81% (M89774) ORF 1 function unknown [Escherichia

120605 coli] gb[AAC75218.l| (AE000305) putative transcriptional regulator LYSR-type

[Escherichia coli K12] gb| AAG57295.1 | E005448_2

(AEO05448) putative transcriptional regulator

LYSR-type [Escherichia coli 0157 :H7] prf ( |2014253BC yeiE gène [Escherichia coli] SEQ ID n~îl9 pir| |C64984 lysine-spécifie permease -

Contig9 from Escherichia coli gb|AAA17053. l| (M89774) lysine SEQ ID n° 6012 PL-1070.1 120760 to p 85% spécifie permease [Escherichia coli]

122241 gb|AAC752l7.l| (AΞ000305) lysine-specific permease [Escherichia coli K12] SEQ ID n~î21 pir| |E72406 hypothetical protein TM0189 -

Contig9 from Thermotoga maritima (strain MSB8) SEQ ID n° 6013 PL-1071.1 122704 to p 40% gb[AAD35281.l|AE001704_2 (AΞ001704) iron(III)

123828 ABC transporter, periplasmic iron-binding protein, putative [Thermotoga maritima] SEQ ID n~122 pir||F71067 probable ferrichrome transport

Contig9 from permease protein - Pyrococcus SEQ ID n° 6014 PL-1072.1 123952 to p 54% horikoshii dbj |BAA30336.l| (AP000005) 343aa

124938 long hypothetical ferrichrome transport permease protein [Pyrococcus horikoshii] SEQ ID n~£23 sp]Q57554|Y089_METJA HYPOTHETICAL ABC TRANSPORTER ATP-BINDING PROTEIN MJ0089 pir| |A64311 ferrie enterobactin transport ATP-

Contig9 from binding protein homolog - SEQ ID n° 6015 PL-1073.1 124935 to p 573 Methanococcus jannaschii gb|AAB98070.l|

125735 (U67466) ferrie enterobactin transport ATP- binding protein [Methanococcus jannaschii] SEQ ID n-î.24

TABLEAU II

sp|P27772|lRGA_VIBCH IRON-REGULATED OUTER

MEMBRANE VIRULENCE PROTEIN PRECURSOR pir| |D82317 iron-regulated outer membrane

Contig9 from virulence protein, TonB receptor SEQ ID n° 6016 PL-1074.1 125866 to 643 family VC0475 [imported] - Vibrio cholerae

127845 (group 01 strain N16961) gb|AAF93648.l| (AE004134) iron-regulated outer membrane virulence protein, TonB receptor family [Vibrio cholerae] SEQ ID n~125 sp | 33016 | YEEF_ECOLI HYPOTHETICAL 49.8 KD

TRANSPORT PROTEIN IN SBCB-HISL INTERGENIC

REGION pir| |Ξ64966 probable amino acid permease yeeF - Escherichia coli gb | AAA16420.1 | (U00009) yeeF [Escherichia coli] dbj |BAA1584 .l|

Contig9 from (D90839) Proline transport protein [Escherichia

SEQ ID n° 6017 PL-1075.1 128564 to 803 coli] dbj |BAA15847.l| (D90840) Proline

129946 transport protein [Escherichia coli] gb|AAC75075.l| (AE000293) putative amino acid/amine transport protein [Escherichia

COli K12] gb|AAG57073.l|AE005427_l (AE005427) putative amino acid/amine transport protein

[Escherichia coli 0157 :H7] SEQ ID n~ï26 sp|P06149|DLD_ΞCOLI D-LACTATE DEHYDROGENASE pir| |DEECDL D-lactate dehydrogenase (EC

1.1.1.28) - Escherichia coli pdb|lF0X|A Chain

A, Crystal Structure Of D-Lactate Dehydrogenase,

A Peripheral Membrane Respiratory

Enzyme. pdb|lF0X(B Chain B, Crystal Structure

Contig9 from

Of D-Lactate Dehydrogenase, A Peripheral

SEQ ID n^» 6018 PL-1076.1 130141 to 31%

Membrane Respiratory Enzyme. emb|CAA25531.l|

131856

(X01067) D-lactate dehydrogenase [Escherichia coli] gb|AAA23688.l| (M10038) D-lactate dehydrogenase [Escherichia coli] gb|AAC75194.l|

(AE000302) D-lactate dehydrogenase, FAD protein,

NADH independent [Escherichia coli

K12] SEQ ID n~ï27

TABLEAU II

sp|P04995|EXl_ECOLI EXODEOXYRIBONUCLEASE I

(EXONUCLEASE I) (DNA

DEOXYRIBOPHOSPHODIESTERASE) (DRPASE) pir| |NCECXl exodeoxyribonuclease I (EC 3.1.11.1)

- Escherichia coli gb] AAA16417.l| (U00009) exonuclease I [Escherichia coli] dbj (BAA15839.l| (D90839) Exodeoxyribonuclease I

Contig9 from (EC 3.1.11.1) (Exonuclease I) (DNA SEQ ID n° 6019 PL-1077.1 131984 to 803 deoxyribophosphodiesterase) (DRPase) .

133414 [Escherichia coli] dbj |BAA15844. l] (D90840)

Exodeoxyribonuclease I (EC 3.1.11.1)

(Exonuclease I) (DNA deoxyribophosphodiesterase) (DRPase) .

[Escherichia coli] gb|AAC75072.l| (AE000292) exonuclease I, 3' --> 5' spécifie; deoxyribophosphodiesterase [Escherichia coli

K12] SEQ ID n~î28 ref |NP_0 6944.l| gp48 [Bacteriophage N15]

Contig9 from pir| |τi3135 protein gp48 - phage N15 SEQ ID n° 6020 PL-4592.1 133570 to m 513 gb|AAC19087.l| (AF064539) gp48 [Bacteriophage

133851

N15] #N/A ref |NP_046945.l| gp49 [Bacteriophage N15]

Contig9 from pir| |T13136 protein gp4 - phage N15 SEQ ID n° 6021 PL-4591.1 133868 to 473 gb|AAC19088.l[ (AF064539) gp49 [Bacteriophage

134197

N15] #N/A

Contig9 from SEQ ID n° 6022 PL-4590.1 134279 to No Hits found

134479 #N/A

TABLEAU II

xr| |F64965 hypothetical protein b2007 -

Escherichia coli dbj | BAA15828.1 | (D90838)

ORF_ID:o348#19~similar to [SwissProt Accession

Number P44117] [Escherichia coli]

Contig9 from dbj |BAA15835.l| (D90839) ORF_ID: o348#19 ; similar

SEQ ID n° 6023 PL-4587.1 136656 to 883 to [SwissProt Accession Number

136973 P44117] [Escherichia coli] gb |AÂC75Ô68.11

(AE000292) putative alpha hélix protein

[Escherichia coli K12] gb| AG57066.1 | AE005426_8

(AE005426) putative alpha hélix protein

[Escherichia coli 0157 :H7] #N/A

Contig9 from pir| ]T12067 hypothetical protein Y - Yersinia

SEQ ID n° 6024 PL-1079.1 137018 to 663 pestis gb|AAC64864.l| (U60647) unknown

137650 [Yersinia pestis] SEQ ID n~î30

Contig9 from gb|AAG55830.l|AE005318_7 (AE005318) RNase E,

SEQ ID n° 6025 PL-1080.1 137835 to 763 membrane attachment, mRNA turnover, maturation

140939 5S RNA [Escherichia coli 0157 :H7] SEQ ID n~ï32 sp|P2385l|RLUC_ECOLI RIBOSOMAL LARGE SUBUNIT

PSEUDOURIDINE SYNTHASE C (PSEUDOURIDYLATE

SYNTHASE) (URACIL HYDROLYASE) pir| [C64852

Contig9 from probable pseudouridylate synthase yceC -

SEQ ID n° 6026 PL-1081.1 141499 to 833 Escherichia coli gb| AC74170.l| (AE000209) orf,

142458 hypothetical protein [Escherichia coli K12] dbj |BAA35894.l| (D90744) Hypothetical 36.0 kd protein in rne-rpmF intergenic région

(orfx) . [Escherichia coli] SEQ ID n~î33 sp|P27244|YCEF_ECOLI HYPOTHETICAL 23.2 KDA

PROTEIN IN RNE-RPMF INTERGENIC REGION (ORFY) pirj |D64852 yeeF protein - Escherichia coli

Contig9 from gb|AAA23829.l[ (M96791) orfY [Escherichia coli]

SEQ ID n° 6027 PL-1082.1 142455 to 733 gb|AAC7417l.l| (AE000209) orf, hypothetical

143063 protein [Escherichia coli K12] dbj |BAA35895. l| (D90744) Hypothetical 23.2 kd protein in rne- rpmF intergenic région (orfy) . [Escherichia coli] SEQ ID n~î34

TABLEAU II

sp|P14189|YCED_ECOLI HYPOTHETICAL 19.3 KDA

PROTEIN IN RNE-RPMF INTERGENIC REGION (G30K) pir| |JV0047_probable membrane protein yceD -

Escherichia coli gb |AAA24574.1 [ (M29698) g30k protein [Escherichia coli] gb | AAC74172.1 |

Contig9 from

(AE000209) orf, hypothetical protein

SEQ ID n° 6028 PL-3850-.1- 1-43188 to 843

[Escherichia coli K12] dbj |BAA35896.l| (D90744)

143712

Hypothetical 19.3 kd protein in rne-rpmF intergenic région (g30k) .

[Escherichia coli] gb|AAG55834.ι|AΞ0053l9_3

(ÀΞ005319) orf, hypothetical protein

[Escherichia coli 0157 :H7] SEQ ID n~3023 sp|P02435|RL32_ECOLI 50S RIBOSOMAL PROTEIN L32 pir| |R5ΞC32 ribosomal protein L32 [validated] -

Escherichia coli gb| AAA24575.1 | (M29698) ribosomal protein L32 [Escherichia coli] dbj |BAA35897.l| (D90744) Ribosomal protein L3 .

Contig9 from

[Escherichia coli] gb | AAC74173.1 ] (AE000209)

SEQ ID n° 6029 PL-4585.1 143725 to 85%

50S ribosomal subunit protein L32 [Escherichia

143895 coli K12] gb|AAC38646.l| (AF044668)

50S ribosomal protein L32 [Salmonella typhimurium] gb | AAG55835.1 | AE005319_4

(AE005319) 50S ribosomal subunit protein L32

[Escherichia coli 0157 :H7] #N/A

Contig9 from sp|085138|PLSX_SALTY FATTY ACID/PHOSPHOLIPID SEQ ID n° 6030 PL-1084.1 143924 to p 8 ^

SYNTHESIS PROTEIN PLSX

144961 SEQ ID n~£35 sp (085139 |FABH_SALTY 3-OXOACYL- [ACYL-CARRIER-

Contig9 from PROTEIN] SYNTHASE III (BETA-KETOACYL-ACP SEQ ID n° 6031 PL-1085.1 144968 to p 85% SYNTHASE III) (KAS III) gb | AC38648.1 |

145921 (AF044668) 3-oxoacyl-acyl carrier protein synthase III [Salmonella typhimurium] SEQ ID n~î36

TABLEAU II

sp|P25715|FABD_ECOLI MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE (MCT) pir||B41856 [acyl- carrier-protein] S-malonyltransferase (EC 2.3.1.39) fabD [validated] -

Escherichia coli pdb|lMLA| Mol_id: 1; Molécule: Malonyl-Coenzyme A Acyl Carrier Protein Transacylase; Chain: Null;

Synonym: Malonyl-Coa Acp

Contig9 from Transacylase; Engineered: Yes emb|CAA77658. l| SEQ ID n° 6032 PL-1086.1 145946 to 843 (Z11565) malonyl CoA-acyl carrier protein

146878 ^" transacylase [Escherichia coli] gb|AAA23742.l| (M87040) malonyl coenzyme A-acyl carrier protein transacylase [Escherichia coli] dbj |BAA35900.l| (D90745) [Acyl-carrier-protein] s-malonyltransferase (EC 2.3.1.39). [Escherichia coli] gb|AAC74176.l| (AE000210) malonyl-CoA- [acyl- carrier-protein] transacylase [Escherichia coli K12] SEQ ID n~237 sp | P25716 | FABG_ECOLI 3 -OXOACYL- [ACYL-CARRIER PROTEIN] REDUCTASE (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) pir|[B42147 3 -oxoacyl- [acyl- carrier-protein] reductase (EC 1.1.1.100) -

Contig9 from Escherichia coli dbj |BAA35901.l| (D90745) 3- SEQ ID n° 6033 PL-1087.1 146886 to 803 oxoacyl- [acyl-carrier-protein] reductase (EC

147620 1.1.1.100) . [Escherichia coli] gb[AAC74177.l| (AE000210) 3 -oxoacyl- [acyl- carrier-protein] reductase [Escherichia coli K12] SEQ ID n~î38

Contig9 from gb|AAG42370.l|AF294440_2 (AF294440) acyl carrier SEQ ID n° 6034 PL-4582.1 147775 to 743 protein [Xanthomonas albilineans]

148011 #N/A

TABLEAU II

s | P39435 | FABF_ECOLI 3 -OXOACYL- [ACYL-CARRIER- PROTEIN] SYNTHASE II (BETA-KETOACYL-ACP SYNTHASE II) (KAS II) pir | 1141060 3-oxoacyl^_

[acyl-carrier-protein] synthase (EC 2.3.1.41) II Escherichia coli emb| CAA84431. l| (Z34979) beta ketoacyl-acyl carrier protein synthase [Escherichia coli]

Contig9 from gb[AAA83255.l| (U20767) beta-ketoacyl-acyl

SEQ ID n° 6035 PL-1088.1 148085 to 86% carrier protein synthase II

149335 [Escherichia coli] gb | AAC74179.1 | (AE000210) 3- oxoacyl- [acyl-carrier-protein] synthase II

[Escherichia coli K12] dbj |BAA35903.l| (D90745)

3 -oxoacyl- [acyl-carrier-protein] synthase (EC

2.3.1.41) Il [Escherichia coli] gb|AAG55841.l|AE005319_10 (AE005319) 3-oxoacyl-

[acyl-carrier-protein] synthase II

[Escherichia coli 0157 :H7] SEQ ID n~ï39

Contig9 from gb|AAG55842.l|AE005319_ll (AE005319) 4-amino-4-

SEQ ID n° 6036 PL-1089.1 149690 to 65% deoxychorismate lyase [Escherichia coli

150514 0157:H7] SEQ ID n~î40 sp|P28306|YCEG_ECOLI HYPOTHETICAL 38.2 KD

PROTEIN IN PABC-HOLB INTERGENIC REGION

Contig9 from pir| |F64853 yceG protein precursor - Escherichia

SEQ ID n° 6037 PL-1090.1 150579 to 70% coli gb|AAC74181.l| (AE000210) putative

151595 thymidylate kinase (EC 2.7.4.9) [Escherichia coli K12] SEQ ID n~î42

Contig9 from sp| 069169 |KTHY_YERPE THYMIDYLATE KINASE (DTMP

SEQ ID n° 6038 PL-1091.1 151601 to 803 KINASE) gb|AAC18855.l[ (AF065312) thymidylate

152239 kinase [Yersinia pestis] SEQ ID n~143

TABLEAU II

sp|f_i863l|HOLB_ECOLI DNA POLYMERASE III, DELTA¹ SUBUNIT pir| |S35523 DNA-directed DNA polymérase

(EC 2.7.7.7) III delta' chain -

Escherichia coli pdb|lA5T| Crystal Structure

Of The Delta Prime Subunit Of The Clamp-Loader

Contig9 from Complex Of Escherichia Coli Dna Polymérase lii

SEQ ID n° 6039 PL-1092.1 152239 to 623 gb|AAA23696.l[ (L01483) DNA polymérase III delta

153228 prime subunit [Escherichia coli] db |BAA35906.l| (D90745) DNA-directed dna polymérase (EC 2.7.7.7) III delta' chain

[Escherichia coli] gb|AAC74183.1 | (AE000210)

DNA polymérase III, delta prime subunit

[Escherichia coli K12] SEQ ID n~ï44 sp | 37346 | YCFH_ECOLI PUTATIVE DEOXYRIBONUCLEASE

YCFH pir| |A64854 probable métal-dépendent hydrolase (EC 3.-.-.-) ycfH - Escherichia

Contig9 from coli gb|AAC7 184.l| (AE000210) orf, SEQ ID n° 6040 PL-1093.1 153254 to 78% hypothetical protein [Escherichia coli K12]

154039 dbj |BAA35907.l] (D90745) Hypothetical protein in holB 3 'région . [Escherichia coli] gb|AAG55846.l|AE005319_15 (AE005319) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~ï45 sp|P3695θ]YCFF_ECOLI HIT-LIKE PROTEIN YCFF pir| | JC5685 histidine triad-like protein ycfF -

Escherichia coli gb|AAC74187.l| (AΞ000211) orf, hypothetical protein [Escherichia coli K12]

Contig9 from dbj |BAA35910.l| (D90745) Hypothetical protein

SEQ ID n° 6041 PL-4580.1 154110 to 86%

HI0961 [Escherichia coli] dbj |BAA35918. l|

154466

(D90746) Hypothetical protein HI0961

[Escherichia coli] gb| AAG55849.1 | EO 05320_3

(AE005320) orf, hypothetical protein

[Escherichia coli 0157 :H7] #N/A db |BAA35912.l| (D90745) Fibronectin-binding

Contig9 from protein B [Escherichia coli] dbj |BAA35920.l[

SEQ ID n° 6042 PL-1094.1 154774 to 563 (D90746) Fibronectin-binding protein B

155343

[Escherichia coli] SEQ ID n-î.46

TABLEAU II

Contig9 from gû|AAG55852.l|AE005320_6 (AE005320) putative SEQ ID n° 6043 PL-1095.1 155330 to p 42% beta-glucosidase (EC 3.2.1.21) [Escherichia

156193 coli 0157 :H7] __ SEQ ID n~347 sp|P75949|YCFO_ΞCOLI HYPOTHETICAL 37.6 KDA

PROTEIN IN FHUΞ-NDH INTERGENIC REGION pir| |H64854 probable glucosidase (EC 3.2.1.-)

Contig9 from ycfo - Escherichia coli gb|AAC74l9l.l| SEQ ID n° 6044 PL-1096.1 156316 to p 803 (AE000211) orf, hypothetical protein

157338 [Escherichia coli K12] dbj |BAA35914.l| (D90745)

Hypothetical protein HI0959 [Escherichia coli] dbj |BAA35922.l| (D90746) Hypothetical protein

HI0959 [Escherichia coli] SEQ ID n~148 sp|P00393[DHNA_ECOLI NADH DEHYDROGENASE pir| |DEECR NADH dehydrogenase (EC 1.6.99.3)

[validated] - Escherichia coli emb| CAA23586.l|

Contig9 from

(V00306) NADH dehydrogenase [Escherichia coli] SEQ ID n° 6045 PL-1097.1 157744 to p 873 dbj |BAA35924.l| (D90746) NADH dehydrogenase (EC

1Ξ9048

1.6.99.3) [Escherichia coli] gb|AAC74193.1 |

(AE000211) respiratory NADH dehydrogenase

[Escherichia coli K12] SEQ ID n~î49

Contig9 from emb|CAB69803.l| (AJ243711) putative subtilase SEQ ID n° 6046 PL-1098.1 159135 to m 24% family serine protease [Bacillus

160811 cereus] SEQ ID n~î50

TABLEAU II

o _| vô 679 |NTPA_METJA NUCLEOSIDE-TRIPHOSPHATASΞ

(NUCLEOSIDE TRIPHOSPHATE

PHOSPHOHYDROLASE) (NTPASE) pir|[C64328 conserved hypothetical protein MJ0226 -

Methanococcus jannaschii pdb|2MJ J Chain A,

Structure-Based Identification Of The

Biochemical Function Of A

Hypothetical Protein From Methanococcus Jannaschii :mj 0226 pdb|2MJP|B Chain B, Structure-

Contig9 from Based Identification Of The Biochemical Function

SEQ ID n° 6047 PL-3849.1 161608 to m 313

Of A Hypothetical Protein From Methanococcus

162114 Jannaschii :mj 0226 pdb|lB78]A Chain A, Structure- Based Identification Of The Biochemical Function

Of A Hypothetical Protein From Methanococcus Jannaschii :mj 0226 pdb|lB78|B Chain B, Structure- Based Identification Of The Biochemical Function Of A Hypothetical Protein From Methanococcus

Jannaschii.-mj 0226 gb|AAB98211.l| (U67478) conserved hypothetical protein [Methanococcus jannaschii] SEQ ID n-3021

Contig9 from SEQ ID n° 6048 PL-4579.1 162507 to No Hits found

162794 #N/A pir| |B8 137 PvcB protein VC1944 [imported] -

Contig9 from

Vibrio cholerae (group 01 strain SEQ ID n° 6049 PL-1099.1 163274 to 533

N16961) gb]AAF95092.l| (AE004270) PvcB protein

164119

[Vibrio cholerae] SEQ ID n~£51 pir| |H83363 pyoverdine biosynthesis protein PvcA

PA2254 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 6050 PL-1100.1 164131 to m 673 gb|AAG05642.l]AE004651_4 (AE004651) pyoverdine

165108 biosynthesis protein PvcA [Pseudomonas aeruginosa] SEQ ID n-î.54

TABLEAU II

sp ] P30958 j MFD_EC0LI TRANSCRIPTION-REPAIR

COUPLING FACTOR (TRCF) pir| |G64855 transcription/repair-coupling protein -

Escherichia coli dbj |BAA35929.1 | (D90746)

Contig9 from Transcription-repair coupling protein mfd SEQ ID n° 6051 PL-1101.1 165827 to m 87^ [Escherichia coli] dbj |BAA35934.l| (D90747)

169273^"" Transcription-repair coupling protein mfd

[Escherichia coli] gb|AAC74198.l( (AE000211) transcription-repair coupling factor,- mutation frequency décline [Escherichia coli

^{" ~} K12] SEQ ID n-î.55

Contig9 from dbj |BAA35936. l | (D90747) Hypothetical protein SEQ ID n° 6052 PL-1102.1 169471 to p 823 HI1555 [Escherichia coli]

170673 SEQ ID n~256 Contig9 from dbj | BAA35937. l | (D90747) Heterocyst maturation SEQ ID n° 6053 PL-1103.1 170666 to p 753 protein (devA) homolog [Escherichia

171370 coli] SEQ ID n~î57 Contig9 from gb|AAG55864.l|AE005321_7 (AE005321) putative SEQ ID n° 6054 PL-1104.1 171370 to p 823 kinase [Escherichia coli θl57:H7]

172617 SEQ ID n~158 pir| |Ξ64856 hypothetical protein bll20 -

Escherichia coli gb| AAC74204. l| (AE000212)

Contig9 from putative nicotinic acid SEQ ID n° 6055 PL-1105.1 172709 to p 773 mononucleotide : 5, 6-dimethylbenzimidazole (DMB)

173560 phosphoribosyltransferase [Escherichia coli K12] dbj [BAA35940.l| (D90747) ORF_ID:θ238#9

[Escherichia coli] SEQ ID n~î59

Contig9 from gb|AAG55931.l|AE005327_l (AE005327) putative SEQ ID n° 6056 PL-1106.1 173616 to p 80% peptidase T [Escherichia coli 0157 :H7]

174881 SEQ ID n-160 Contig9 from pir| [E64857 ycfD protein - Escherichia coli SEQ ID n° 6057 PL-1107.1 175060 to m 80% gb|AAC742l2.l| (AEO00 13) orf, hypothetical

176181 protein [Escherichia coli K12] SEQ ID n~£61 Contig9 from gb|AAC38776.l| (AF041833) putative sensor kinase SEQ ID n° 6058 PL-1108.1 176265 to m 82% [Providencia stuartii]

177728 SEQ ID n~î62

TABLEAU II

Contig9 from emb|CAA47i48.l| (X66587) phoP [Yersinia

SEQ ID n° 6059 PL-1109.1 177748 to m 79% pseudotuberculosis]

178416 SEQ ID n~£63

Contig9 from

SEQ ID n° 6060 PL-4577.1 178508 to No Hits found

178696 #N/A

Contig9 from gb|AAG55957.l|AE005329_l (AE005329)

SEQ ID n° 6061 PL-1110.1 178654 to m 813 adenylosuccinate lyase [Escherichia coli

180024 0157 :H7] SEQ ID n~!65 sp|P25746|YCFC_EC0LI HYPOTHETICAL 22.9 KDA

PROTEIN IN PURB-ICDA INTERGENIC REGION

(ORF-23) pir||si9211 ycfC protein - Escherichia

Contig9 from coli emb|CAA41995.l| (X59307) ORF-23

SEQ ID n° 6062 PL-1111.1 180048 to m 723 [Escherichia coli] gb|AAC74216.l| (AE000213)

180674 orf, hypothetical protein [Escherichia coli K12] dbj |BAA35954.l| (D90748) Hypothetical protein

23. [Escherichia coli] dbj (BAA35963.1 | (D90749)

Hypothetical protein 23. [Escherichia coli] SEQ ID n~166

Contig9 from gb|AAG55959.l|AE005329_3 (AE005329) orf, SEQ ID n° 6063 PL-1112.1 180677 to m 903 hypothetical protein [Escherichia coli 0157 :H7]

181780 SEQ ID n~167 s | P75965 | YMFB_ECOLI HYPOTHETICAL 17.4 KDA

PROTEIN IN TRMU-ICD INTERGENIC REGION pir| |C64858 probable dNTP pyrophosphohydrolase bil34 - Escherichia coli gb|AAC74 18 ,l|

Contig9 from (AEO00213) putative phosphohydrolase

SEQ ID n° 6064 PL-3848.2 181865 to 743 [Escherichia coli K12] dbj |BAA35956.l| (D90748)

182335 Hypothetical protein YGL067 [Escherichia coli] dbj ]BAA35965.l| (D90749) Hypothetical protein

YGL067w [Escherichia coli] gb|AAG55960.l|AE005329_4 (AE005329) putative phosphohydrolase [Escherichia coli 0157 :H7] #N/A

TABLEAU II

sp|P75966|YMFC_ECOLI HYPOTHETICAL 24.9 KDA

PROTEIN IN TRMU-ICDA INTERGENIC REGION

Contig9 from dbj |BAA35957.lL(D90748) Hypothetical protein SEQ ID n° 6065 PL-4576.1 - 182-307 to m 783

HI0694 [Escherichia coli] dbj |BAA35966.1 |

182843

(D90749) Hypothetical protein HI0694

[Escherichia coli] #N/A sp | O8200 | IDH_ECOLI ISOCITRATE DEHYDROGENASE

[NADP] (OXALOSUCCINATE DECARBOXYLASE)

(IDH) (NADP-r-SPECIFIC ICDH) (IDP) pir| |DCECIS isocitrate dehydrogenase (NADP+) (EC 1.1.1.42)

[vàïidated] - Escherichia coli pdb|lAI2| Isocitrate Dehydrogenase Complexed

With Isocitrate, Nadp+, And Calcium

(Flash-Cooled) pdb|lAI3| Orbital Steering In

The Catalytic Power Of Enzymes : Small

Structural Changes With Large Catalytic

Contig9 from Conséquences pdb|lIKA| Isoσitrate

SEQ ID n° 6066 PL-1113.2 183076 to 95% Dehydrogenase (E.C.1.1.1.42) Complexed With

184329 Alpha-Ketoglutarate pdb | 1SJS | Access To

Phosphorylation In Iεocitrate Dehydrogenase May

Occur By Domain Shifting pdb|5lCD|

Isocitrate Dehydrogenase (E . C .1.1.1.42 ) Complex

With Mg2+ And Isocitrate pdb|9ICD|

Isocitrate Dehydrogenase (E.C.1.1.1.42) Complex

With NADP+ pdb|3ICD( Isocitrate Dehydrogenase

(E.C.1.1.1.42) gb|AAA24006.l| (J02799) isocitrate dehydrogenase (icd; EC 1.1.1.42)

[Escherichia coli] dbj |BAA35958.l|

(D90748) Isocitrate dehydrogenase (NADP) (EC #N/A

Contig9 from emb|CAC22108.l| (AL512862) hypothetical repeat

SEQ ID n° 6067 PL-4574.1 184449 to 33^ containing protein,- duplicated in S

184844 pombe [Schizosaccharomyces pombe] #N/A

TABLEAU II

ρdb|lDY3|A Chain A, Ternary Complex Of

7, 8-Dihydro-6-

Hydroxy ethylpterinpyrophosphokinase From

Escherichia Coli With Atp And A Substrate

Analogue. pdb|lEQθ|A Chain A, Crystal Structure

Contig9 from

Of A Ternary Complex Of 6- SEQ. ID n° 6068 PL-3847.1 185063 to -rt -4X3

Hydroxymethyl-7, 8-Dïhydropterin

185605

Pyrophosphokinase From E. Coli With

Mgampcpp And 6-Hydroxymethy1-7,8-

Dihydropterin At 1.25 Angstrom

Resolution pdb|lHKA| ^'~6-Hydroxymethyl-7, 8-

Dihydropterin Pyrophosphokinase SEQ ID n~3019 pir| |B82680 pteridine reductase l XF1457

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 6069 PL-1114.1 185686 to 593 (strain 9a5c) gb |AAF84266.1 | AEO03975_9

186450 (AE003975) pteridine reductase 1 [Xylella fastidiosa] SEQ ID n~169

Contig9 from SEQ ID n° 6070 PL-1115.1 186495 to m No Hits found

187856 SEQ ID n~170 Contigs from emb|CAC01604.l| (AJ269505) peptide synthetase SEQ ID n° 6071 PL-1116.1 187863 to m 293 [Anabaena sp. 90]

190670 SEQ ID n~i71 pir| |C81683 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) (EC 1.2.4.4)

Contig9 from alpha/beta El chain TCO618 [similarity] - SEQ ID n° 6072 PL-1117.1 190712 to m 47% Chlamydia muridarum (strain Nigg)

192664 gb(AAF39449.l[ (AE002330) 2 -oxoisovalerate dehydrogenase, El component, alpha and beta subunit [Chlamydia muridarum] SEQ ID n~3L72

Sp|Q9ZDY5|Y178_RICPR HYPOTHETICAL PROTEIN RP17E

Contig9 from pir||F7l728 hypothetical protein RP178 - SEQ ID n° 6073 PL-3846.1 192699 to 36%

Rickettsia prowazekii emb[CAA14645. l|

193283 (AJ235270) unknown [Rickettsia prowazekii] SEQ ID n~3018

TABLEAU II

Contig9 from dbj |BAA9 678.1 | (AB029431) GTP cyclohydrolase I

SEQ ID n° 6074 PL-1118.1 193280 to 373 [Tetrahymena pyriformis]

193984 SEQ ID n~î73

Contig9 from emb|CAB72138.ι( (AJ011922) BphR protein

SEQ ID n° 6075 PL-1119.1 194668 to 703 [Ralstonia eutropha]

195561 SEQ ID n~î74 pir| |H82085 sodium/alanine symporter VC2356

Contig9 from

[imported] - Vibrio cholerae (group SEQ ID n° 6076 PL-1120.1 197959 to 813

01 strain N16961) gb | AF95499.1 | (AE004306)

199431 sodium/alanine symporter [Vibrio cholerae] SEQ ID n~î76

Contig9 from gb|AAG55249.l|AE005268_2 (AE005268) putative

SEQ ID n° 6077 PL-1121.1 199732 to P 583 regulator [Escherichia coli 0157 :H7]

200553 SEQ ID n-î.77

Contig9 from

SEQ ID n° 6078 PL-4570.1 200816 to m No Hits found

201244 #N/A

Contig9 from emb|CAB88438.l| (AL353815) putative intégral

SEQ ID n° 6079 PL-3845.1 201583 to 49% membrane protein [Streptomyces

202077 coelicolor A3 (2)] SEQ ID n~3017

Contig9 from

SEQ ID n° 6080 PL-7043.1 202207 to m No Hits found

202341 #N/A pdb|lD5Y|A Chain A, Crystal Structure Of The E.

Coli Rob Transcription Factor In

Complex ith Dna pdb|lD5Y|C Chain C, Crystal

Structure Of The E. Coli Rob Transcription

Contig9 from

Factor In Complex With Dna SEQ ID n° 6081 PL-3844.1 202364 to m 37% pdb|lD5Y|B Chain B, Crystal Structure Of The E.

202753

Coli Rob Transcription Factor In

Complex With Dna pdb|lD5Y|D Chain D, Crystal

Structure Of The E. Coli Rob Transcription

Factor In Complex ith Dna SEQ ID n~3016

Contig9 from SEQ ID n° 6082 PL-4569.1 203064 to No Hits found

203207 #N/A

TABLEAU II

Contig9 from gD|AAG54416.l|AE005187_9 (AE005187) aromatic SEQ ID n° 6083 PL-1122.1 203507 to 77% amino acid transport protein [Escherichia coli

204886 0157 :H7] SEQ ID n~î78 sp|P3700l|CRCA_ECOLI CRCA PROTEIN pir)|D64796 crcA protein - Escherichia coli gb[AAA67555.l[

Contig9 from

(L29054) putative [Escherichia coli]

SEQ ID n° 6084 PL-1123.1 205205 -to- — 55% gb|AAB40822.l| (U82598)^' hypothetical protein 205828

[Escherichia coli] gb| AC73723.1 | (AE000167) orf, hypothetical protein [Escherichia coli K12] SEQ ID n-î.79 sp|P36996|CSPC_ECOLI COLD SHOCK-LIKE PROTEIN

CSPC (CSP-C)^~ pir| |S43618 cold shock protein homolog cspC - Escherichia coli dbj |BAA05854.l|

(D28496) CspC (MsmB) [Escherichia coli]

Contig9 from gb]AAA236l9.l| (L28430) cold-shock protein SEQ ID n° 6085 PL-4568.1 206429 to 55^ [Escherichia coli] dbj |BAA15634.1 | (D90826)

206638 Cold shock protein CspC [Escherichia coli] gb|AAC74893.l| (AE000276) cold shock protein

[Escherichia coli K12] gb| AAG56812.ι| E005405_3

(AE005405) cold shock protein [Escherichia coli

0157.-H7] #N/A sp | P55882 | THID_SALTY PHOSPHOMETHYLPYRIMIDINE

Contig9 from

KINASE (HMP- HOSPHATE KINASE) (HMP-P

SEQ ID n° 6086 PL-1124.1 206938 to 783

KINASE) gb|AAB66492.l| (U87940) HMP-P kinase

207735

[Salmonella typhimurium] SEQ ID n-î.80

Contig9 from sp j P71 95 | LF1_EC0LI FRUCTOSE-BISPHOSPHATE

SEQ ID n° 6087 PL-1125.1 208030 to 92% ALDOLASE CLASS I (FBP ALDOLASE)

209079 SEQ ID n~ï.81

Contig9 from gb|AAG57144.l|AE005435_2 (AΞ005435) orf,

SEQ ID n° 6088 PL-1126.1 211266 to 37% hypothetical protein [Escherichia coli θl57:H7]

212642 SEQ ID n~î82

Contig9 from gb]AAK02603.l| (AE006087) unknown [Pasteurella

SEQ ID n° 6089 PL-4566.1 212841 to 67% multocida]

213185 #N/A

TABLEAU II

gb|AAG57142.l|AE005434_6 (AE005434)

Contig9 from transcriptional response regulatory protein SEQ ID n° 6090 PL-1127.1 213283 to m 81%

(sensor BaeS) [Escherichia coli 213987

0157.-H7] SEQ ID n-183

Contig9 from gb|AAG57141.l|AE005434_5 (AE005434) sensor SEQ ID n° 6091 PL-1128.1 213984 to m 71% protein (for BaeR) [Escherichia coli 0-1-5^7 :H7]

215372 SEQ ID n~î84 sp|P76399]YEGO_ECOLI HYPOTHETICAL 111.0 KDA

PROTEIN IN ALKA-BAES INTERGENIC REGION pir| |C64974 hypothetical protein b2076 -

Contig9 from

Escherichia coli (strain K-12) ^~ϋj |BAA15932.1 |

SEQ ID n° 6092 PL-1129.1 215493 to m 863

(D90846) Acriflavin résistance protein F (EnvD

218603 protein) . [Escherichia coli] gb[AAC75137.l| (AE000297) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~î85 sp|P76398|YEGN_ECOLI HYPOTHETICAL 112.1 KDA

PROTEIN IN ALKA-BAES INTERGENIC REGION

Contig9 from pir| |B64974 hypothetical protein b2075 - SEQ ID n° 6093 PL-1130.1 218600 to m 863 Escherichia coli (strain K-12) dbj (BAA15929. l[

221746 (D90845) Acriflavin résistance protein D.

[Escherichia coli] gb|AAC75136.l| (AE000297) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~287

Contig9 from sp|P76397|YΞGM_ECOLI HYPOTHETICAL 44.5 KDA SEQ ID n° 6094 L-^ÎÏSl.l 221746 to m 74% PROTEIN IN ALKA-BAES INTERGENIC REGION

222951 PRECURSOR SEQ ID n~∑88 Contig9 from emb|CAB91168.l| (AL355920) putative inosine- SEQ ID n° 6095 PL-1132.1 223442 to p 51% uridine preferring nucleoside hydrolase

224371 [Schizosaccharomyces pombe] SEQ ID n~î89 pir||T35340 probable adenosine deaminase -

Contig9 from

Streptomyces coelicolor emb[CAB42949.1 | SEQ ID n° 6096 PL-1133.1 224397 to p 46%

(AL049863) putative adenosine deaminase

225404

[Streptomyces coelicolor A3 (2)] SΞQ ID n~290

TABLEAU II

pιi||F72285 transcription regulator, crp family

Contig9 from Thermotoga maritima (strain MSB8) SEQ ID n° 6097 PL-1134.1 225724 to 38% gb|AAD36246.l]AΞ001774_3 (AE001774)

226386 transcriptional regulator, crp family

[Thermotoga maritima] SEQ ID n~î91 sp|P22106| SNB_ECOLI ASPARAGINE SYNTHETASE B

[GLUTAMINE-HYDROLYZING] pir | |AJECN asparagine synthase (glutamine-hydrolyzing) (EC 6.3.5.4) -

Contig9 from Escherichia coli gb|AAA23498. l| (J05554) SEQ ID n° 6098 PL-1135.1 226575 to m 47? asparagine synthetase B [Escherichia coli]

228107 dbj |BAA35317.l| (D90706) Asparagine synthase

(glutamine-hydrolyzing) (EC 6.3.5.4)

[Escherichia coli] gb|AAC73768.l] (AE000171) asparagine synthetase B [Escherichia coli K12] SEQ ID n~192 sp | Q9RVD3 | ROA_DEIRA 3 -PHOSPHOSHIKIMATE 1-

Contig9 from

CARBOXYVINYLTRANSFERASE (5- SEQ ID n° 6099 PL-1136.1 228143 to m 493

ENOLPYRUVYLSHIKIMATE-3 -PHOSPHATE SYNTHASE) (EPSP

229498

SYNTHASE) (EPSPS) SEQ ID n~ï93 sp | Q57925 | AROA_ME A PROBABLE 3 -PHOSPHOSHIKIMATE

1-CARBOXYVINYLTRANSFERASΞ (5-

Contig9 from

ENOLPYRUVYLSHIKIMATΞ-3 -PHOSPHATE SYNTHASE) (EPSP SEQ ID n° 6100 PL-1137.1 229526 to m 43%

SYNTHASE) (EPSPS) gb | AB98493.1 | (U67500) 3-

230830 phosphoshikimate-1-carboxyvinyltransferase

(aroA) [Methanococcus jannaschii] SEQ ID n~î94 pir| |A75567 conserved hypothetical protein -

Contig9 from

Deinococcus radiodurans (strain RI) SEQ ID n° 6101 PL-4562.1 230881 to m 50% gb|AAF09626.l|AE001867_l (AE001867) conserved

231279 hypothetical protein [Deinococcus radiodurans] #N/A

Contig9 from s | 55641 | 4RH_RHISN HYPOTHETICAL 52.5 KDA SEQ ID n° 6102 PL-1138.1 231852 to p 33% PROTEIN Y4RH gb | AAB91833.1 | (AE000094) Y4rH

233090 [Rhizobium sp. NGR234] SEQ ID n~î95 pir| |C75275 hypothetical protein - Deinococcus

Contig9 from radiodurans (strain RI) SEQ ID n° 6103 PL-1139.1 233160 to p 40% gb|AAF11982.l|AE002073_12 (AE002073)

233951 hypothetical protein [Deinococcus radiodurans] SEQ ID n~î96

TABLEAU II

Contig9 from gb|AAC34891.l| (AF085682) exopolyphosphatase SEQ ID n° 6104 PL-1140.1 234286 to m 843 [Salmonella typhimurium]

235818 SEQ ID n~198 sp|P28688|PPK_ECOLI POLYPHOSPHATE KINASE pir||A44306 polyphosphate kinase (EC 2.7.4.1) -

Escherichia coli gb|AAC75554 ,l| (AE000336)

Contig9 from polyphosphate kinase [Escherichia coli K12] SEQ ID n° 6105 PL-1141.1 235822 to 87% dbj [BAA16389.1] (D90878) polyphosphate kinase

237891

(EC 2.7.4.1) [Escherichia coli] gb|AAG57611.l|AE005479_9 (AE005479) polyphosphate kinase^" [Escherichia coli 0157 :H7] SEQ ID n~î99 dbj |BAA15286.l| (D90799) Spermidine NI- acetyltransferase (EC 2.3.1.57) (Diamine acetyltransferase) (SAT) . [Escherichia coli]

Contig9 from dbj [BAA15308.l| (D90800) Spermidine NI-

SEQ ID n° 6106 PL-3842.1 237955 to 763 acetyltransferase (EC 2.3.1.57) (Diamine

238521 acetyltransferase) (SAT) . [Escherichia coli] dbj |BAA15310.l| (D90801) Spermidine NI- acetyltransferase (EC 2.3.1.57) (Diamine acetyltransferase) (SAT) . [Escherichia coli] SEQ ID n~3015 pdb|3GAR| A Ph-Dependent Stablization Of An

Active Site Loop Observed From Low

And High Ph Crystal Structures Of Mutant

Contig9 from Monomeric Glycinamide Ribonucleotide

SEQ ID n° 6107 PL-1142.1 238643 to 78% Transformylase pdb|2GAR| A Ph-Dependent

239281 Stablization Of An Active Site Loop Observed

From Low And High Ph Crystal

Structures Of Mutant Monomeric

Glycinamide Ribonucleotide Transformylase SEQ ID n~200

Contig9 from gb|AAG14577.l|AF293164_l (AF293164)

SEQ ID n° 6108 PL-1143.1 239278 to m 86% phosphoribosylaminoimidazole synthetase

240318 [Escherichia coli] SEQ ID n~201

Contig9 from

SEQ ID n° 6109 PL-4560.1 240393 to No Hits found

240548 #N/A

TABLEAU II

pιr| |A65026 uracil phosphoribosyltransferase (EC 2.4.2.9) upp - Escherichia coli Contig9 from gb|AAC75551.l| (AE000336) uracil

SEQ ID n° 6110 PL-1144.1 240545 to 94% phosphoribosyltransferase [Escherichia coli K12]

241171 gb|AAG57608.1 | AE005479_6 (AE005479) uracil phosphoribosyltransferase [Escherichia coli

0157 :H7] SEQ ID n~202

Contig9 from gb|AAC35810.l| (AF071757) HicB [Haemophilus

SEQ ID n° 6111 PL-4558.1 241409 to 64% influenzae]

241756 #N/A

Contig9 from gb|AAC35821.l| (AF071760) HicA [Haemophilus

SEQ ID n° 6112 PL-4557.3 241897 to 38% influenzae]

242001 #N/A pir| |G82219 6-phospho-beta-glucosidase VC1284

Contig9 from

[imported] - Vibrio cholerae (group

SEQ ID n° 6113 PL-1145.1 242220 to 713

01 Strain N16961) gb|AAF94443.l| (AE004207) 6-

243527 phospho-beta-glucosidase [Vibrio cholerae] SEQ ID n~203

Contig9 from gb|AAA23559.l| (M93573) PTS enzyme III σel

SEQ ID n° 6114 PL-4556.1 243524 to 64% [Escherichia coli]

243883 #N/A pir| |E82219 PTS system, cellobiose-specific IIC component VC1282 [imported] - Vibrio

Contig9 from cholerae (group 01 strain N16961) SEQ ID n° 6115 PL-1146.1 243902 to m 693 gb|AAF94441.l| (AE004207) PTS System, cellobiose

245230 spécifie ne component [vibrio cholerae] SEQ ID n~204 pir| (D82219 PTS system, cellobiose-specific IIB component VC1281 [imported] - Vibrio

Contig9 from cholerae (group Ol strain N16961) SEQ ID n° 6116 PL-4555.1 245260 to 61% gb|AAF94440.l| (AE004207) PTS System, cellobiose

245565 spécifie IIB component [Vibrio cholerae] #N/A

Contig9 from SEQ ID n° 6117 PL-1147.1 245825 to No Hits found

246451 SEQ ID n~205

TABLEAU II

_o.t,_|P76570|YFGE_EC0LI HYPOTHETICAL 28.4 KDA

PROTEIN IN FOCB-URAA INTERGENIC REGION pir| |G65025 hypothetical protein b2496 -

Cont g9 from

Escherichia coli (strain K-12) gb|AAC75549.l| SEQ ID n° 6118 PL-1148.1 246734 to p 87%

(AE000336) putative DNA réplication factor

247435

[Escherichia coli K12] gb|AAG57606.l| E005479_4

(AE005479) putative DNA réplication factor

[Escherichia coli 0157 -.H7] SEQ ID n~206

Contig9 from gb|AAG57605.l|AE005479_3 (AE005479) putative SEQ ID n° 6119 PL-4554.1 247590 to m 76% oxidoreductase [Escherichia coli 0157 :H7]

- 247946 #N/A pir[ [E65025 hypothetical protein b2494 -

Contig9 from

Escherichia coli (strain K-12) gb| AC75547.1 | SEQ ID n° 6120 PL-1149.1 247956 to m 74%

(AE000336) orf, hypothetical protein

249419

[Escherichia coli K12] SEQ ID n~ 07 sp|P77406|PERM_ECOLI PUTATIVE PERMEASE PERM pir| |D65025 hypothetical protein b2493 -

Contig9 from Escherichia coli (strain K-12) gb |AAC75546. l| SEQ ID n° 6121 PL-1150.1 249556 to p 793 (AE000335) putative permease [Escherichia coli

250635 K12] dbj |BAA16382.1 | (D90878) similar to

[SwissProt Accession Number P43970]

[Escherichia coli] SEQ ID n~209

TABLEAU II

sp|P^i480|BCP_ECOLI BACTERIOFERRITIN COMIGRATORY

PROTEIN pir| |B49749 thioredoxin-dépendent hydroperoxide peroxidase (EC 1.1J 1.-)

[validated] - Escherichia coli gb| AAC75533.ι|

(AΞ000335) bacterioferritin comigratory protein

[Escherichia coli K12]

Contig9 from dbj |BAA16358.l| (D90876) bacterioferritin

SEQ ID n° 6122 PL-3841.1 250761 to m 823 comigratory protein [Escherichia coli] 251231 dbj |BAA16368.l| (D90877) bacterioferritin comigratory protein [Escherichia coli] gb|AAB88562 ,l| (M63654) b cterioferritin comigratory protein [Escherichia coli] gb|AAG57590.l|AE005477_8 (AE005477) bacterioferritin comigratory protein

[Escherichia coli 0157.-H7] SEQ ID n~3014 pir| |F65023 gcvR protein - Escherichia coli gb|AAC75532.l| (AE000335) transcriptional régulation of gcv operon [Escherichia coli K12] dbj |BAA16356.l| (D90876) GCV OPERON

Contig9 from

TRANSCRIPTIONAL REGULATOR. [Escherichia coli]

SEQ ID n° 6123 PL-3840.1 251258 to 723 dbj |BAA16366.1 | (D90877) GCV OPERON

251803

TRANSCRIPTIONAL REGULATOR. [Escherichia coli] gb]AAG57589.l|AE005477_7 (AE005477) transcriptional régulation of gcv operon

[Escherichia coli 0157 :H7] SEQ ID n~3013

TABLEAU II

t, | P05640 | DAPAJ3COLI DIHYDRODIPICOLINATE

SYNTHASE (DHDPS) pir|[SYECDP dihydrodipicolinate synthase (EC 4.2.1.52)

[validated] - Escherichia coli pdb | IDHP |A Chain A, Dihydrodipicolinate Synthase

Contig9 from pdb | IDHP (B chain B, Dihydrodipicolinate Synthase SEQ ID n° 6124 PL~ll^"5Ï.Ï 252187 to 82% gb|AAC75531.l| (AΞ000335) dihydrodipicolinate

253086 synthase [Escherichia coli K12] dbj |BAA16355.l|

(D90876) dihydrodipicolinate synthase (EC

4.2.1.52) [Escherichia coli]

^~dbj |BAA16365.1 | (D90877) dihydrodipicolinate synthase (EC 4.2.1.52) [Escherichia coli] SEQ ID n~ 10

Contig9 from pir[ [D65023 lipoprotein-34 precursor - SEQ ID n° 6125 PL-1152.1 253103 to 68% Escherichia coli gb| AC75530.l| (AE000335)

254152 lipoprotein-34 [Escherichia coli K12] SEQ ID n~211

TABLEAU II

sp I 1155 I UR7_ECOLI

PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE

SYNTHASE (SAICAR SYNTHETASE) pir| |C36146 phosphoribosylaminoimidazolesuccinocarboxamide synthase (EC 6.3.2.6) - Escherichia coli gb | AA24448.11 ^~(M3T928 5 ' -phosphoribosyl-

5-aminoimidazole-4- N-succinocarboxamide synthetase (EC 6.3.2.6) [Escherichia coli] gb|AAC75529.l| (AE000334)

Contig9 from phosphoribosylammoimidazole-succinocarboxamide SEQ ID n° 6126 PL-1153.1 254432 to 91% synthetase - SAICAR synthetase [Escherichia coli

255145

K12] dbj |BAA16353.l| (D90876) phosphoribosylaminoimidazolesuccinocarboxamide synthase (EC 6.3.2.6) [Escherichia coli] dbj |BAA16363.l| (D90877) phosphoribosylaminoimidazolesuccinocarboxamide synthase (EC 6.3.2.6) [Escherichia coli] gb|AAG57586.l|AE005477_4 (AE005477) phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase [Escherichia coli

0157.-H7] SEQ ID n~212

Contig9 from dbj |BAB06239.l| (AP001515) transposase related SEQ ID n° 6127 PL-1154.1 255522 to p 21% protein (20) [Bacillus halodurans]

256547 SEQ ID n~ 13 pir||S74455 ABC-type transport protein slrl488 -

Contig9 from

Synechocystis sp. (strain PCC 6803) SEQ ID n° 6128 PL-1155.1 256943 to 48% dbj |BAA16607.l[ (D90899) ABC transporter

258580

[Synechocystis sp . ] SEQ ID n~214 pir| |S74461 ABC transporter slrl494 -

Contig9 from

Synechocystis sp. (strain PCC 6803) SEQ ID n° 6129 PL-1156.1 258577 to 4£ dbj |BAA16613.l[ (D90899) ABC transporter

260232

[Synechocystis sp . ] SEQ ID n~215

Contig9 from SEQ ID n° 6130 PL-4551.1 260476 to No Hits found

260676 #N/A

TABLEAU II

Contig9 from SEQ ID n° 6131 PL-4550.1 260669 to p No Hits found

260875 #N/A pir| |B72391 conserved hypothetical protein -

Contig9 from

Thermotoga maritima (strain MSB8) SEQ ID n° 6132 PL-1157.1 260983 to 343 gb|AAD35423.l|AE001714_14 (AE001714) conserved

262158 hypothetical protein [Thermotoga maritima] SEQ ID n~216 sp | P45743 | DHBB_BACSU ISOCHORISMATASE (2,3

DIHYDRO-2,3 DIHYDROXYBENZOATE SYNTHASE)

(SUPEROXIDE-INDUCIBLE PROTEIN 1) (SOI1)

Contig9 from pir| |B69615 isochorismatase (EC 3.3T2.1) dhbB - SEQ ID n° 6133 PL-4549.1 262170 to m 283

Bacillus subtilis gb| AAC44633.l| (U26444)

262400 isochorismatase [Bacillus subtilis] emb|CABi5l87.l | (Z99120) isochorismatase

[Bacillus subtilis] #N/A pir| |H83346 probable ATP-binding/permease fusion

ABC transporter PA2390 [imported] -

Contig9 from

Pseudomonas aeruginosa (strain PAOl) SEQ ID n° 6134 PL-1158.1 262435 to 48% gb|AAG05778.l|AE004665_5 (AE004665) probable ATP'

263658 binding/permease fusion ABC transporter

[Pseudomonas aeruginosa] SEQ ID n~217

Contig9 from emb|CAA11724.l| (AJ223978) putative ABC

SEQ ID n° 6135 PL-1159.1 263661 to 573 transporter, YvrO [Bacillus subtilis]

264326 SEQ ID n~218 s | P75830 | YBJY_ECOLI HYPOTHETICAL 41.7 KDA

Conti 9 from

PROTEIN IN AQPZ-CSPD INTERGENIC REGION

SEQ ID n° 6136 PL-1160.1 264310 to m 51% dbj |BAA35597.l| (D90725) MtrC protein

265467

[Escherichia coli] SEQ ID n-220

Contig9 from emb|CACOl604.l| (AJ269505) peptide synthetase

SEQ ID n° 6137 PL-1161.1 265492 to 423 [Anabaena s . 90]

269883 SEQ ID n~221

Contig9 from

SEQ ID n° 6138 PL-3838.1 269901 to m No Hits found

270395 SEQ ID n~3011

TABLEAU II

Contig9 from SEQ ID n° 6139 PL-1162.1 270392 to m No Hits found

271402 ID n~222 pir| |E70091 hypothetical protein yydG - Bacillus

Contig9 from subtilis dbj |BAA11275.1 | (D78193) yydG

SEQ ID n° 6140 PL-1163.1 272145 to m 29%

[Bacillus subtilis] emb| CAB16054.1 | (Z99124)

273209 yydG Bacillus subtilis] ID 11-223^"

Contig9 from emblCAA70529.l[ (Y09356) ATP-dependent SEQ ID n° 6141 PL-1164.1 273588 to p 70% activating enzyme [Pseudomonas fluorescens]

275207 SEQ ID n~224 sp | P15048 | ΞNTB_ECOLI ISOCHORISMATASE (2,3

DIHYDRO-2,3 DIHYDROXYBENZOATE SYNTHASE) pir| (YXECIC isochorismatase (EC 3.3.2.1) -

Escherichia coli gb|AAA16102.1 | (M24148) isochorismatase [Escherichia coli] gbJAAA76835.l] (M24143) 2, -dihydro-2 , 3-

Contig9 from dihydroxybenzoate synthase [Escherichia SEQ ID n° 6142 PL-1165.1 275230 to 71% coli] gb|AAB40795.l| (U82598) isochorismatase

275883

[Escherichia coli] gb|AAC73696.1 | (AE000165)

2 , 3 -dihydro-2 , 3 -dihydroxybenzoate synthetase, isochroismatase [Escherichia coli K12] gb|AAG54930.l|AE005239_5 (AΞ005239) 2,3-dihydro-

2 , 3-dihydroxybenzoate synthetase , isochroismatase [Escherichia coli 0157 :H7] SEQ ID n~225 gb|AAG54931.l|AE005239_6 (AE005239) 2,3-dihydro-

2 , 3 -dihydroxybenzoate dehydrogenase,

Contig9 from enterochelin biosynthesis [Escherichia coli SEQ ID n° 6143 PL-1166.2 275951 to 68% 0157 :H7 EDL933] dbj |BAB34058.1 |

276697 (AP002552) 2,3-dihydro-2, 3-dihydroxybenzoate dehydrogenase [Escherichia coli

0157 : H7] #N/A

TABLEAU II

sp|P76240|YEAL_ECOLI HYPOTHETICAL 15.3 KD

PROTEIN IN GAPA-RND INTERGENIC REGION pir| |E64939 hypothetical protein bl789 -

Escherichia coli (strain κ-12) dbj JBAA15588. ι[

Contig9 from (D90822) ORF_ID.-o331#5; similar to [SwissProt SEQ ID n° 6144 PL-3837.1 277036 to 693 Accession Number P44110] [Escherichia

277488 coli] dbj |BAA15590.l| (D90823) ORF_ID: o331#5 ; similar to [SwissProt Accession Number

P44110] [Escherichia coli] gb|AAC74859.l|

(AE000274) orf, hypothetical protein

[Escherichia coli K12] SEQ ID n~3010

Contig9 from gb|AAG57584.l|AE005477_2 (AE005477) orf, SEQ ID n° 6145 PL-1167.1 277493 to 613 hypothetical protein [Escherichia coli 0157 :H7]

279541 SEQ ID n~2 7 dbj |BAA16347.l| (D90875) similar to [PIR

Contig9 from Accession Number D42959] [Escherichia SEQ ID n° 6146 PL-4548.1 279492 to 713 coli] dbj |BAA16351.1 | (D90876) similar to [PIR

279680 Accession Number D42959] [Escherichia coli] #N/A

Contig9 from gb[AAK03105.l| (AE006143) unknown [Pasteurella SEQ ID n° 6147 PL-1168.1 279680 to 61% multocida]

280357 SEQ ID n~228

TABLEAU II

sp | 24176 | DAPE_ECOLI SUCCINYL-DIAMINOPIMELATE

DESUCCINYLASE (SDAP) pir| |A42959 succinyl- diaminopimelate desuccinylase (EC 3.5.1.18) -_ Escherichia coli emb| CAA40665.1 |

(X57403) succinyldiaminopimelate desuccinylase [Escherichia coli] gb|AAB22798.l| (S41760) N- succinyl-L-diaminopimelic acid desuccinylase,

Contig9 from DapE, MsgB {EC 3.5.1.18} [Escherichia SEQ ID n° 6148 PL-1169.1 280354 to m 82% coli, Peptide, 375 aa] gb] AAC75525.l|

281481 (AE000334) N-succinyl-diaminopimelate deacylase [Escherichia coli K12] dbj |BAA16346.l| (D90875) succinyl- diaminopimelate desuccinylase (EC 3.5.1.18) [Escherichia coli] dbj |BAA16350.1 | (D90876) succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) [Escherichia coli] SEQ ID n~229 sp|P24178 |YFFB_ECOLI PROTEIN YFFB pir||B42959

14K hypothetical protein (5' of dapE) -

Escherichia coli emb | CAA4066 .1 | (X57403) orf

[Escherichia coli] gb]AAC75524.l| (AE000334)

Contig9 from orf, hypothetical protein [Escherichia coli K12]

SEQ ID n° 6149 PL-4546.1 281483 to 653 dbj |BAA16345.l| (D90875) similar to [PIR

281869

Accession Number B42959] [Escherichia coli] dbj |BAA16349.1| (D90876) similar to [PIR

Accession Number B42959] [Escherichia coli] #N/A

Contig9 from gb|AAG57328.l|AΞ005452_l (AE005452)

SEQ ID n° 6150 PL-1170.1 282096 to m 74% nitrate/nitrite response regulator (sensor NarQ)

282731 [Escherichia coli θl57:H7] SEQ ID n~231

Contig9 from gb|AAG57572.l|AE005475_7 (AE005475) putative

SEQ ID n° 6151 PL-1171.1 283418 to 893 multimodular enzyme [Escherichia coli 0157 :H7]

285697 SEQ ID n~232

TABLEAU II

pir| |E83058 hypothetical protein PA4705

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 6152 PL-1172.1 285784 to p 483 (Strain PAOl) gb| AG08091.l| AE004884_9

286674 (AE004884) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~ 33 sp|Q05613|τθNB_PSEPU TONB PROTEIN pir||S28444

Contig9 from tonB protein seudomonas putida SEQ ID n° 6153 PL-1173.1 286828 to p 433 emb]CAA49716.1 (X70139) inner-membrane protein

287628 TonB [Pseudomonas putida] SEQ ID n~23

Contig9 from gb(AAG56835.l|AE005407_3 (AE005407) protease II SEQ ID n° 6154 PL-1174.1 287760 to p 663 [Escherichia coli 0157 :H7]

289817 SEQ ID n~235 pir| |A81436 probable outer membrane siderophore receptor CJ0178 [imported] -

Contig9 from

Campylobacter jejuni (strain NCTC 11168) SEQ ID n° 6155 PL-1175.1 289980 to p 54% emb|CAB72661.l| (AL139074) putative outer

292223 membrane siderophore receptor

[Campylobacter jejuni] SEQ ID n~236 sp|P04994|EX7L_ΞCOLI EXODEOXYRIBONUCLEASE VII

LARGE SUBUNIT (EXONUCLEASE VII LARGE SUBUNIT) pir] JNCEC7 exodeoxyribonuclease VII

Contig9 from (EC 3.1.11.6) large chain - Escherichia

SEQ ID n° 6156 PL-1176.1 292311 to m 793 coli (strain K-12) gb|AAC75552.l| (AE000337)

293684 exonuclease VII, large subunit [Escherichia coli

K12] dbj |BAA16396.1 | (D90880) exodeoxyribonuclease VII (EC 3.1.11.6) large chain [Escherichia coli] SEQ ID n~237

Contig9 from dbj |BAA16395.l| (D90880) IMP dehydrogenase (EC

SEQ ID n° 6157 PL-1177.1 293857 to 863 1.1.1.205) [Escherichia coli]

295323 SEQ ID n~238

TABLEAU II

sp| 04079|GUAA_ECOLI GMP SYNTHASE [GLUTAMINE- HYDROLYZING] (GLUTAMINE AMIDOTRANSFERASE) (GMP SYNTHETASE) pir| | SYECGU GMP synthase (glutamine-hydrolyzing) (EC 6.3.5.2) [validated] Escherichia coli pdb | 1GPM | A Chain A, Escherichia Coli Gmp Synthetase Complexed With Amp And Pyrophosphate pdb|lGPM|C Chain C, Escherichia Coli Gmp Synthetase Complexed With Amp And

Contig9 from Pyrophosphate pdb|lGPM|B Chain B, Escherichia SEQ-ID n° 6158 PL-1178.1 295397 to 893

Coli Gmp Synthetase Complexed with Amp And

296974

Pyrophosphate pdb|lGPM|D Chain D, Escherichia

Coli Gmp Synthetase Complexed With Amp And

Pyrophosphate gb|AAB18619.l| (M10101) GMP synthetase [Escherichia coli] gbJAAC75560. l|

(AE000337) GMP synthetase (glutamine- hydrolyzing) [Escherichia coli K12] dbj |BAA16394.1 | (D90880) GMP synthase (glutamine- hydrolyzing) (EC 6.3.5.2) [Escherichia coli] SEQ ID n~239 gb|AAB69349.l| (AF015307) DNA invertase

Contig9 from [Acetobacter pasteurianus] gb|AAC97i79.l| SEQ ID n° 6159 PL-4543.1 297004 to 793 (AF044847) putative DNA invertase [Acetobacter

297318 pasteurianus] #N/A

Contig9 from sp|P05103|MTP7_PSEAE MODIFICATION METHYLASE SEQ ID n° 6160 PL-1179.1 297427 to 84% PAER7I (ADENINE-SPECIFIC METHYLTRANSFERASE

299076 PAER7I) (M.PAER7I) SEQ ID n~240 sp|P05104|T2P7_PSEAE TYPE II RESTRICTION ENZYME PAER7I (ENDONUCLEASE PAER7I) (R.PAER7I)

Contig9 from pir] |NDPS7A type II site-specific SEQ ID n° 6161 PL-1180.1 299077 to 96 deoxyribonuclease (EC 3.1.21.4) PaeR7I -

299817 Pseudomonas aeruginosa plasmid pMG7 emb|CAA27026.l| (X03274) put. endonuclease (aa 1<

246) [Pseudomonas aeruginosa] SEQ ID n-242

TABLEAU II

Contig9 from SEQ ID n° 6162 PL-1181.1 299831 to p No Hits found

300643 SEQ ID n~243 Contig9 from SEQ ID n° 6163 PL-7254.1 300708 to p No Hits found

300878 #N/A Cohtig9 from SEQ ID n° 6164 PL-4537.1 301093 to m No Hits found

301353 #N/A pir|]G82648 conserved hypothetical protein

Contig9 from XF1702 [imported] - Xylella SEQ ID n° 6165 PL-4536.1 301547 to p 723 fastidiosa (strain 9a5c)

301840 gb|AAF84511.l|AΞ003994_10 (AE003994) conserved hypothetical protein [Xylella fastidiosa] #N/A sp|P55383|Y4CA_RHISN HYPOTHETICAL 133.7 KD

Contig9 from

PROTEIN Y4CA pir| |T28628 Y4cA protein - SEQ ID n° 6166 PL-1182.1 302022 to m 113

Rhizobium sp. plasmid pNGR234a gb|AAB91631.1 [

305900

(AE000067) Y4cA [Rhizobium s . NGR234] SEQ ID n~ 4

Contig9 from SEQ ID n° 6167 PL-4532.1 306084 to m No Hits found

306266 #N/A sp|P36999|RRMA_ECOLI RIBOSOMAL RNA LARGE SUBUNIT

METHYLTRANSFERASE A (RRNA (GUANINE-N1

) -METHYLTRANSFERASE) (23S RRNA M1G745

METHYLTRANSFERASE) pir| |S49049 probable S-

Contig9 from adenosylmethionine-dépendent methyltransferase SEQ ID n° 6168 PL-1183.1 306601 to 703 yebH - Escherichia coli

307419 db^ |BAA05855.l| (D28496) ORF30 [Escherichia coli] dbj ]BAA15633.l| (D90826) Mycinamicin- resistance protein MyrA. [Escherichia coli] gb|AAC74892.l| (AE000276) putative enzyme

[Escherichia coli K12] SEQ ID n~245

TABLEAU II

sp|P76264|YEBN_EC0LI HYPOTHETICAL 22.1 KD

PROTEIN IN MANZ-CSPC INTERGENIC REGION pir| |E64943 probable membrane protein bl82l -

Contig9 from —

Escherichia coli dbj |BAA15632.l| (D90826)

SEQ ID n° 6169 PL-1184.1 307486 to m 65%

ORF_ID:o335#4; similar to [SwissProt Accession 308067

Number P39154] [Escherichia coli] gb|AAC74891.l| (AE00027&7 orf hypothetical protein [Escherichia coli K12] SEQ ID n~246

Contig9 from gb]AAG56809.l[AE005404_12 (AE005404) orf,

SEQ ID n° 6170 PL-3834.1 308493 to m 70% hypothetical protein [Escherichia coli 0157 :H7] 308951 ^"~ SEQ ID n~3009 sp|P08188|PTND_ECOLI PTS SYSTEM, MANNOSE- SPECIFIC IID COMPONENT (EIID-MAN) (MANNOSE-PERMEASE IID COMPONENT) (PHOSPHOTRANSFERASE ENZYME II, D

COMPONENT) (EII-M-MAN) pir| |WQECMM phosphotransferase system enzyme II (EC 2.7.1.69), mannose-specific, factor

IID - Escherichia coli gb|AAA24445.l| (J02699)

Contig9 from mannose permease subunit II-M-Man [Escherichia SEQ ID n° 6171 PL-1185.1 309072 to 87% coli] dbj |BAA15631.l] (D90826) PTS system,

309938 Mannose-specific IID component (EIID-MAN)

(Mannose- permease IID component)

(Phosphotransferase enzyme II, D component) (EII-M-MAN) . [Escherichia coli] gb|AAC74889.l| (AE000276) PTS enzyme IID, mannose-specific [Escherichia coli K12] gb|AAG56808.l|AE005404__ll (AE005404) PTS enzyme

IID, mannose-specific [Escherichia coli

0157:H7] SEQ ID n~2 7

TABLEAU II

sp]P08187|PTNC_ΞCOLI PTS SYSTEM, MANNOSE- SPECIFIC IIC COMPONENT (EIIC-MAN) (MANNOSE-PERMEASE IIC COMPONENT) (PHOSPHOTRANSFERASE ENZYME II, C

COMPONENT) (EII-P-MAN) pir] | QECMP phosphotransferase system enzyme II (EC 2.7.1.69), mannose-specific, factor

IIC - Escherichia coli gb|AAA24444.l| (J02699) mannose permease subunit II-P-Man [Escherichia

Contig9 from coli] dbj |BAA15625.l] (D90825) SEQ ID n° 6172 PL-1186.1 309952 to m 893 Phosphotransferase system enzyme II (EC

310752 2.7.1.69), mannose-specific, factor

II-P [Escherichia coli] dbj [BAA15630.1 |

(D90826) hosphotransferase system enzyme II (EC

2.7.1.69), mannose-specific, factor

II-P [Escherichia coli] gb [AAC74888.l|

(AE000276) PTS enzyme IIC, mannose-specific

[Escherichia coli K12] gb |AAG56807.1 [AEO05 04_10 (AE005404) PTS enzyme

IIC, mannose-specific [Escherichia coli

0157:H7] SEQ ID n~2 8

TABLEAU II

t,y|P08186| TNAJ3COLI PTS SYSTEM, MANNOSE- SPECIFIC IIAB COMPONENT (EIIAB-MAN) (MANNOSE-PERMEASE IIAB COMPONENT) (PHOSPHOTRANSFERASE ENZYME II, AB

COMPONENT) (EIII-MAN) pir| |WQECM3 phosphotransferase system enzyme II (EC 2.7.1.69), mannose-specific, factor

IIAB - Escherichia coli gb|AAA24443.l| (J02699)

Contig9 from mannose permease εubunit III-Man [Escherichia SEQ ID n° 6173 PL-1187.1 310811 to m 823 coli] dbj |BAA15624.l| (D90825)

311794 Phosphotransferase system enzyme II (EC 2.7.1.69), Mannose-specific, factor

III [Escherichia coli] dbj |BAA15629.l| (D90826) Phosphotransferase system enzyme II (EC 2.7.1.69), Mannose-specific, factor

III [Escherichia coli] gb|AAC74887.l| (AE000276) PTS enzyme IIAB, mannose-specific [Escherichia coli K12] SEQ ID n~249 sp]P16095|SDHL_ECOLI L-SERINE DEHYDRATASE 1 (L- SERINE DEAMINASE 1) (SDH 1) (L-SDl) pir| | DWECL L- serine dehydratase (EC 4.2.1.13) 1 - Escherichia coli gb[AAA63580 ,l| (M28695) L-

Contig9 from serine deaminase [Escherichia coli]

SEQ ID n° 6174 PL-1188.1 312417 to m 853 dbj |BAA15621.1| (D90825) L-serine dehydratase 1

313781 (EC 4.2.1.13) (L-serine deaminase 1)

(SDH 1) (L-SDl) . [Escherichia coli] gb|AAC74884.l| (AΞ000275) L-serine deaminase [Escherichia coli K12] SEQ ID n~250

Contig9 from gb|AAG56802.l|AΞ005404_5 (AΞ005404) orf,

SEQ ID n° 6175 PL-3833.1 313956 to m 67% hypothetical protein [Escherichia coli 0157 :H7]

314519 SEQ ID n~3008

TABLEAU II

sp| £-12680 |PABB_SALTY PARA-AMINOBENZOATE SYNTHASE

COMPONENT I (ADC SYNTHASE) pir| |A31132 p-

Contig9 from aminobenzoate synthase (ΞC 4.1.3.-) component I -

SEQ ID -n° 6176 PL-1189.1 314516 to m 743

Salmonella typhimurium

315886 gb|AAA88618. l| (M22079) p-aminobenzoate synthase component I [Salmonella typhimurium] SEQ ID n~251 sp|P76260 |YOAH_ECOLI HYPOTHETICAL 6.6 KD PROTEIN

IN FADD-PABB INTERGENIC REGION pir| [C64942

Contig9 from hypothetical protein blδll - Escherichia coli SEQ ID n° 6177 PL-4529.1 316026 to 553 (strain K-12) gb|AAC74881.1 | (AE000275) orf,

316205 hypothetical protein [Escherichia coli K12] gb|AAG56800.l|AE005404_3 (AE005404) orf, hypothetical protein [Escherichia coli 0157 :H7] #N/A sp|P33 19]YEBF_ECOLI HYPOTHETICAL LIPOPROTEIN

YEBF PRECURSOR pir[ |G64946 lipoprotein yebF precursor - Escherichia coli gb|AAA23859.l|

Contig9 from (L20897) putative [Escherichia coli] SEQ ID n° 6178 PL-4528.1 316364 to 413 dbj |BAA15653.l| (D90827) ORF_ID : θ336#14 ; similar

316687 to [SwissProt Accession Number

P33219] [Escherichia coli] gb|AAC74917. l|

(AE000278) orf, hypothetical protein

[Escherichia coli K12] #N/A sp| 032449 |PIP_SΞRMA PROLINE IMINOPEPTIDASΞ (PIP) (PROLYL AMINOPEPTIDASE) (PAP) pir| | JC5696 prolyl aminopeptidase (EC 3.4.11.5) - Serratia

Contig9 from marcescens pdb|lQTR|A Chain A, Crystal

SEQ ID n° 6179 PL-1190.1 316761 to 33%

Structure Analysis Of The Prolyl Aminopeptidase

317714

From Serratia Marcescens dbj |BAA23336.l|

(D87897) -prolyl aminopeptidase [Serratia marcescens] SEQ ID n~253

TABLEAU II

a |f28689 ] HOLE_ΞCOLI DNA POLYMERASE III, THETA

SUBUNIT pir| |S34951 DNA-directed DNA polymerase

(EC 2.7.7.7) III thêta chain -

Escherichia coli gb|AAA23697.l| (L04572) DNA polymerase III thêta subunit [Escherichia coli] gb|AAA23982.ι| (L05381) DNA polymerase III thêta

Contig9 from subunitf FÊscherichia coli] dbj |BAA15650.1 | SEQ ID n° 6180 PL-4526.1 317892 to m 713

(D90827) DNA-directed DNA polymerase (EC

318122

2.7.7.7) III q chain [Escherichia coli] gb|AAC749l2.l| (AE000278) DNA polymerase

III, thêta subunit [Escherichia coli K12] gb|AAG56832.l|AE005406_ll (AE005406) DNA polymerase III thêta subunit [Escherichia coli

0157 :H7] #N/A pir[ |F82368 ferritin VC0078 [imported] - Vibrio

Contig9 from cholerae (group Ol strain N16961) SEQ ID n° 6181 PL-3832.1 318436 to p 66% gb|AAF93256.l| (AE004098) ferritin [Vibrio

318939 cholerae] SEQ ID n~3007

Contig9 from gb|AAG56831.l|AE005406_10 (AE005406) orf, SEQ ID n° 6182 PL-4525.1 319134 to p 51% hypothetical protein [Escherichia coli 0157 :H7]

319520 #N/A Contig9 from gb|AAG56830.l|AE005406_9 (AE005406) putative SEQ ID n° 6183 PL-1191.1 319523 to p 57% résistance protein [Escherichia coli 015 :H7]

320416 SEQ ID n-254 sp|P76277|YEBY_ECOLI HYPOTHETICAL 12.4 KDA

PROTEIN IN PPHA-HOLE INTERGENIC REGION

Contig9 from PRECURSOR pir||G64945 hypothetical protein SEQ ID n° 6184 PL-3831.1 320616 to p 41% bl839 precursor - Escherichia coli

320969 gb|AAC74909.l| (AE000278) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~S006

Contig9 from sp | P7627 | YEBV_ECOLI HYPOTHETICAL 8.8 KDA SEQ ID n° 6185 PL-4524.1 321321 to m 653 PROTEIN IN PRC-PPHA INTERGENIC REGION

321563 #N/A

TABLEAU II

sp| ^76270 |YEBR_ΞCOLI PROTEIN YEBR pir||H64944 probable membrane protein bl832 - Escherichia coli dbj |BAA15640.l| (D90826) ORF_ID:θ335#13 ;

Contig9 from similar to [SwissProt Accession Number SEQ ID n° 6186 PL-3830.1 322229 to 693 P36088] [Escherichia coli] dbj |BAA15645.1 |

322726 (D90827) 0RF_lD:o335#13; similar to [SwissProt Accession Number P36088] [Escherichia coli] gb|AAC74902.l| (AE000277) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~3005

Contig9 from sp|P45577|PR0Q_EC0LI PROP EFFECTOR

SEQ ID n° 6187 PL-1192.1 322822 to 753 gb|AAD41527.l|L48409_l (L48409) ProQ

323541 [Escherichia coli] SEQ ID n~255

Contig9 from gb|AAG56820.l|AE005405_ll (AE005405) carboxy-

SEQ ID n° 6188 PL-1193.1 323561 to 833 terminal protease for penicillin-binding protein

325612 3 [Escherichia coli 0157 :H7] SEQ ID n~ 56

Contig9 from gb|AAG56819.l|AE005405_10 (AE005405) heat shock

SEQ ID n° 6189 PL-1194.1 325942 to 863 protein, intégral membrane protein

326829 [Escherichia coli 0157 :H7] SEQ ID n~257 sp|P77529|YDJN_ΞCOLI HYPOTHETICAL SYMPORTER YDJN pir| |A64932 hypothetical protein bl729 -

Escherichia coli (strain K-12) dbj |BAA15509.1 |

(D90815) Proton/sodium-glutamate symport protein

Contig9 from (Glutamate-aspartate carrier protein) .

SEQ ID n° 6190 PL-1195.1 326897 to 883 [Escherichia coli] dbj |BAA1551 .l|

328288 (D90816) Proton/sodium-glutamate symport protein

(Glutamate-aspartate carrier protein) .

[Escherichia coli] gb|AAC74799.l|

(AE000268) part of a kinase [Escherichia coli

K12] SEQ ID n~258

Contig9 from gb|AAG56714.l|AΞ005396_l (AE005396) orf,

SEQ ID n° 6191 PL-3829.1 328476 to m 633 hypothetical protein [Escherichia coli 0157 :H7]

329024 SEQ ID n~S003

TABLEAU II

sp|P77247|YNIC_EC0LI HYPOTHETICAL 24.3 KD

PROTEIN IN PFKB-CEDA INTERGENIC REGION pir[ |G64931 ynic protein - Escherichia coli

Contig9 from dbj |BAA15508.l| (D90815) Phosphoglycolate

SEQ ID n° 6192 PL-1196.1 329362 to m 733 phosphatase (EC 3.1.3.18). [Escherichia

330027 coli] dbj |BAA15511.l| (D90816) Phosphoglycolate phosphatase (EC 3.1.3.18). [Escherichia coli] gb|AAC74797.l| (AE000267) putative phosphatase [Escherichia coli K12] SEQ ID n~259

Contig9 from sp|Q56956|YFΞΞ_YERPE PUTATIVE YFEABCD REGULATOR SEQ ID n° 6193 PL-3828.1 330214 to 74% YFEE gb[AAC46l51.l| (U50903) YfeΞ [Yersinia

330755 pestis] SEQ ID n~3002 pir| |E64931 hypothetical protein bl725 -

Escherichia coli dbj |BAA15501.l| (D90814)

ORF_ID:o324#5; similar to [SwissProt Accession

Number P46381] [Escherichia coli]

Contig9 from dbj |BAA15507.l| (D90815) ORF_ID :θ3 #5; similar

SEQ ID n° 6194 PL-1197.1 330812 to 74% to [SwissProt Accession Number

331681 P46381] [Escherichia coli] dbj |BAA15510.l|

(D90816) ORF_ID-.o324#5; similar to [SwissProt

Accession Number P46381] [Escherichia coli] gb|AAC74795.l| (AE000267) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~260

Contig9 from sp|Q56955|YFED_YERPE CHELATED IRON TRANSPORT

SEQ ID n° 6195 PL-1198.1 331800 to m 72% SYSTEM MEMBRANE PROTEIN YFED gb | AC 6150.1 |

332687 (U50597) YfeD [Yersinia pestis] SEQ ID n~261

Contig9 from sp|Q56954|YFEC_YERPE CHELATED IRON TRANSPORT

SEQ ID n° 6196 PL-1199.1 332684 to m 883 SYSTEM MEMBRANE PROTEIN YFEC gb | AC46149.1 |

333562 (U50597) YfeC [Yersinia pestis] SEQ ID n~262

Contig9 from

SEQ ID n° 6197 PL-1200.1 333559 to m 873 gb|AAC46148.l| (U50597) YfeB [Yersinia pestis]

334455 SEQ ID n~265

Contig9 from

SEQ ID n° 6198 PL-1201.1 334452 to 823 gb | AAC46147. l | (U50597 ) YfeA [Yersinia pestis]

335372 SEQ ID n~266

TABLEAU II

_t,p_|Jr,6009|MLTΞ_ECOLI MEMBRANE-BOUND LYTIC MUREIN

TRANSGLYCOSYLASE E (MUREIN HYDROLASE E)

Contig9 from pir||F64865 murein hydrolase E (EC 3.2.1.-) - SEQ ID n° 6199 PL-1202.1 335590 to p 633 Escherichia coli gb|AAC74277.l| (AΞ000217)

336261 murein transglycosylase E [Escherichia coli K12] dbj |BAA3605l.ι| (D90754) Hypothetical protein

HI0761 [Escherichia coli] SEQ ID n~267 pir[ |T14593 syringomycin synthetase -

Contig9 from

Pseudomonas syringae pv. syringae SEQ ID n° 6200 PL-1203.1 337217 to p 323 gb|AAC80285.l| (AF047828) syringomycin

386320 synthetase [Pseudomonas syringae pv. syringae] SEQ ID n~268 sp|P00955|SYT_ECOLI THREONYL-TRNA SYNTHETASE

(THREONINE- -TRNA LIGASE) (THRRS) pir||SYECTT threonine--tRNA ligase (EC 6.1.1.3) -

Escherichia coli pdb|lQF6|A Chain A, Structure

Contig9 from Of E. Coli Threonyl-Trna Synthetase Complexed

SEQ ID n° 6201 PL-1204.1 386698 to 923 ith its Cognate Trna dbj (BAAl5498.l| (D90814)

388626 Threonine--tRNA ligase (EC 6.1.1.3) [Escherichia coli] dbj |BAA15504. l| (D90815) Threonine--tRNA ligase (EC 6.1.1.3) [Escherichia coli] gb[AAC74789.l| (AE000267) threonine tRNA synthetase [Escherichia coli K12] SEQ ID n~269 sp]P3332l|lF3_SALTY TRANSLATION INITIATION

Contig9 from FACTOR IF-3 gb | AAC36814.1 | (L11254) translation SEQ ID n° 6202 PL-3824.1 388744 to 92% intitiation factor IF3 [Salmonella

389169 typhimurium] SEQ ID n~3001

TABLEAU II

sp|i>07085|RL35_ECOLI 50S RIBOSOMAL PROTEIN L35

(RIBOSOMAL PROTEIN A) pir] |R5EC35 ribosomal protein L35 [validated] - Escherichia coli dbj |BAA15484.1 | (D90813) Ribosomal protein L35

Contig9 from [Escherichia coli] dbj |BAA15496.1 | (D90814) SEQ ID n° 6203 PL-4513.1 389267 to 753 Ribosomal protein L35 [Escherichia coli] ^_ 389464 gb|AAC74787.ι] (AE000266) 50S ribosomal subunit protein A [Escherichia coli K12] gb|AAG56704.l|AE005394_13 (AE005394) 50S ribosomal subunit protein A [Escherichia coli

0157 :H7] #N/A sp|P0242l|RL20_ECOLI 50S RIBOSOMAL PROTEIN L20 pir| |R5EC20 ribosomal protein L20 [validated] -

Escherichia coli gb | AAC74786. l| (AE000266) 50S

Contig9 from ribosomal subunit protein L20, and regulator SEQ ID n° 6204 PL-4512.1 389506 to 95%

[Escherichia coli K12]

389862 gb|AAG56703.l|AE005394_12 (AE005394) 50S ribosomal subunit protein L20, and regulator

[Escherichia coli 0157:H7] #N/A dbj |BAA15482.l| (D90813) Phenylalanine--tRNA

Contιg9 from ligase (EC 6.1.1.20) a chain SEQ ID n° 6205 PL-1205.1 390134 to 87% [Escherichia coli] dbj [BAA15494.1 | (D90814)

391117 Phenylalanine--tRNA ligase (EC 6.1.1.20) a chain

[Escherichia coli] SEQ ID n~270

TABLEAU II

sp | PO7395 | SYFB_ECOLI PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN (PHENYLALANINE--TRNA

LIGASE BETA CHAIN) (PHERS) pir || 141284 phenylalanine--tRNA ligase (EC 6.1.1.20) beta-subunit - Escherichia coli pir||SYECFB phenylalanine--tRNA ligase (EC

6.1.1.20) beta chain - Escherichia

Contig9 from coli gb|AAA51470.l| (K02844) phenylalanyl-tRNA SEQ ID n° 6206 PL-1206.1 391133 to p 873 synthetase beta-subunit [Escherichia

393520 coli] dbj |BAA15481.l] (D90813) Phenylalanine-- tRNA ligase (EC 6.1.1.20) b chain

[Escherichia coli] dbj |BAA15493.l| (D90814)

Phenylalanine--tRNA ligase (EC 6.1.1.20) b chain

[Escherichia coli] gb| AC74783.l| (AE000266) phenylalanine tRNA synthetase, beta-subunit

[Escherichia coli K12] SEQ ID n~271 sp]P23302]lHFA_SΞRMA INTEGRATION HOST FACTOR

Contig9 from

ALPHA-SUBUNIT (IHF-ALPHA) pir | |A38173 SEQ ID n° 6207 PL-4510.1 393525 to p 943 intégration host factor alpha chain - Serratia

393821 marcescens #N/A

Contig9 from gb|AAA23526.l| (M14031) cytoplasmic membrane SEQ ID n° 6208 PL-1207.1 393887 to p 743 protein [Escherichia coli]

394894 SEQ ID n~272 Contig9 from gb|AAG56696.l|AE005394_5 (AEO05394) ATP-binding SEQ ID n° 6209 PL-1208.1 394898 to p 543 component of vitamin B12 transport system

395674 [Escherichia coli 0157:H7] SEQ ID n~273 SEQ ID n° 6210 PL-1209.1

SEQ ID n° 6211 PL-1210.1

TABLEAU II

o_k/|P77398[YFBG_ECOLI HYPOTHETICAL 74.3 KD

PROTEIN IN AIS-PMRD INTERGENIC REGION pir| |E64996 hypothetical protein b2255 - Escherichia coli (strain K-12) gb|AAC75315.l|

Contig9 from (AEO00315) putative transformylase [Escherichia

SEQ ID n° 6212 PL-1211.1 397959 to 813 coli K12] dbj |BAA16078.1 | (D90856) METHIONYL- 399941 - TRNA FORMYLTRANSFERASE (EC 2.1.2.9). [Escherichia coli] dbj ]BAA16082.l| (D90857) METHIONYL-TRNA FORMYLTRANSFERASE (EC 2.1.2.9). [Escherichia coli] SEQ ID n~277 pir| |F64996 hypothetical protein b2256 -

Contig9 from Escherichia coli (strain K-12) gb| AAC75316.l| SEQ ID n° 6213 PL-1212.1 399941 to 683 (AΞ000315) orf, hypothetical protein

400834 [Escherichia coli K12] SEQ ID n~278

Contig9 from gb(AAG57388.1 | AE005458_5 (AE005458) orf, SEQ ID n° 6214 PL-1213.1 400842 to 653 hypothetical protein [Escherichia coli 0157 :H7]

402503 SEQ ID n~279 Contig9 from gb]AAG57389.l|AE005458_6 (AE005458) Z3516 gène SEQ ID n° 6215 PL-4507.1 402518 to 58% product [Escherichia coli 0157 :H7]

402841 #N/A Contig9 from gb|AAC04776.l| (AF036677) unknown [Salmonella SEQ ID n° 6216 PL-4506.1 402874 to 593 typhimurium]

403218 #N/A

Sp|P23898|NLPC_EC0LI PROBABLE LIPOPROTEIN NLPC

PRECURSOR (ORF-17) pir| |D64929 probable lipoprotein nlpC precursor - Escherichia coli gb|AAA23529.l| (M14031) (possible lipoprotein)

Cσntig9 from [Escherichia coli] dbj |BAA15476. l] (D90813) SEQ ID n° 6217 PL-3822.1 403324 to 693 Probable lipoprotein NlpC precursor (ORF-17) .

403809 [Escherichia coli] dbj |BAA15488.1 |

(D90814) Probable lipoprotein NlpC precursor

(ORF-17) . [Escherichia coli] gb|AAC74778.l| (AE000266) lipoprotein

[Escherichia coli K12] SEQ ID n~2999

TABLEAU II

Contig9 from SEQ ID n° 6218 PL-1214.1 404819 to No Hits found

405748 SEQ ID n~280 pir| |G82452 conserved hypothetical protein

VCA0482 [imported] - Vibrio cholerae

Contig9 from

(group 01 strain N16961) gb] AAF96227.l| SEQ ID n° 6219 PL-4504.1 405898 to P 41%

(AE004370) conserved hypothetical protein

406224

[Vibrio cholerae] gb| AAF96386.l| (AE004380) conserved hypothetical protein [Vibrio cholerae] #N/A

Contig9 from SEQ ID n° 6220 PL-3821.1 406340 to 42% emb|CAC05783.l| (AL391753) 0RF47,

406750 SEQ ID n~2998 Contig9 from SEQ ID n° 6221 PL-3820.1 406904 to m No Hits found

407326 SEQ ID n~2997 pir| |D8307l probable ATP-binding component of ABC transporter PA4594 [imported]

Contig9 from

Pseudomonas aeruginosa (strain PA01) SEQ ID n≈ 6222 PL-1215.1 407769 to 67% gb|AAG07982.l|AE004873_4 (AE004873) probable ATP-

408380 binding component of ABC transporter [Pseudomonas aeruginosa] SEQ ID n~281 pir| |C83071 probable permease of ABC transporter PA4593 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PA01) SEQ ID n° 6223 PL-1216.1 408382 to 63% gb|AAG07981.l|AE004873_3 (AE004873) probable

409587 permease of ABC transporter [Pseudomonas aeruginosa] SEQ ID n~282 pir| |B83071 hypothetical protein PA4592

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 6224 PL-1217.1 409580 to 77% (Strain PAOl) gb|AAG07980.l| E004873_2

411058 (AE004873) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~283

TABLEAU II

_tir| [A83071 hypothetical protein PA4591

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 6225 PL-1218.1 411051 to p 61% (strain PAO±2 gb|AAG07979. l|AE004873_1

412328 (AE004873) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~284

Contig9 from emb|CAC01603.l|- (AJ269505) peptide synthetase SEQ ID n° 6226 PL-1219.1 4Î2413 to m 40% [Anabaena sp. 90]

414212 SEQ ID n~285 pir| |B83357 probable MFS transporter PA2314

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 6227 PL-1220.1 414322 to m 703 (strain PA01) gb| AAG05702.l| AE004657_9

415521 (AE004657) probable MFS transporter [Pseudomonas aeruginosa] SEQ ID n~287

Contig9 from emb|CAB87990.l| (AJ277403) indigoidine synthase SEQ ID n° 6228 PL-1221.1 415567 to m 323 [Erwinia chrysanthemi]

418317 SEQ ID n~288 pir| |D83357 probable transcription regulator

PA2316 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 6229 PL-1222.1 418745 to 66% gb|AAG05704.l|AE004657_ll (AE004657) probable

419632 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~289

Contig9 from SEQ ID n° 6230 PL-3818.1 419789 to No Hits found

420244 SEQ ID n~2995 Contig9 from pir| |S00485 gène 11-1 protein precursor - SEQ ID n° 6231 PL-4502.1 421372 to 68% malaria parasite (Plasmodium

421554 falciparum) (fragments) #N/A Contig9 from sp|Q52620|PQRA_PROVU REGULATORY PROTEIN PQRA SEQ ID n° 6232 PL-4501.1 422364 to m 80% dbj |BAA02757.1 | (D13561) PQRA [Proteus

422729 vulgaris] #N/A Contig9 from SEQ ID n° 6233 PL-1223.1 422993 to No Hits found

423607 SEQ ID n~290

TABLEAU II

Λ. _| |S54440 he in-spécifie ATP-binding protein

Contig9 from

[validated] - Yersinia enterocolitica SEQ ID n° 6234 PL-1224.1 423657 to m 63% emb|CAA54864.l| (X77867) ATPase component — 424451 -

[Yersinia enterocolitica] SEQ ID n~291 sp |Q5699 |HMUU_YERPΞ HEMIN TRANSPORT SYSTEM

Contig9 from

PERMEASE PROTEIN HMUU pir| |T12072 ABC-type SEQ-ID n° 6235 PL-1225.1 424451 to m 79%- permease - Yersinia pestis g |AAC64869. l|

425452

(U60647) ABC-type permease [Yersinia pestis] SEQ ID n~292

Contig9 from emb|CAA54866.l| (X77867) hemin binding protein SEQ ID n° 6236 PL-1226.1 425449 to m 72%

[Yersinia enterocolitica]

426267 SEQ ID n~293 sp]P31517|HEMS_YEREN HEMIN TRANSPORT PROTEIN

Contig9 from

HEMS pir| |S54436 hemS protein [validated] - SEQ ID n° 6237 PL-1227.1 426264 to m 74%

Yersinia enterocolitica emb| CAA54865. l|

427337

(X77867) hemS [Yersinia enterocolitica] SEQ ID n~294 sp|Q56989|HMUR_YERPE HEMIN RECEPTOR PRECURSOR

Contig9 from pir| |T12069 hemin receptor - Yersinia pestis SEQ ID n° 6238 PL-1228.1 427368 to m 75% gb|AAC64866.l| (U60647) TonB-dépendent outer

429389 membrane receptor [Yersinia pestis] SEQ ID n~295 sp|P31516|HEMP_YEREN HEMIN UPTAKE PROTEIN HEMP

Contig9 from pir] |S2804i hemP protein - Yersinia SEQ ID n° 6239 PL-4497.1 429479 to m 43% enterocolitica emb| CAA48249.1] (X68147) hemP

429676

[Yersinia enterocolitica] #N/A gb[AAG56691.l|AE005393_8 (AE005393) 3-deoxy-D-

Contig9 from arabinoheptulosonate- 7-phosphate synthase SEQ ID n° 6240 PL-1229.1 429849 to m 80%

(DAHP synthetase, tryptophan repressible)

430895

[Escherichia coli 0157 :H7] SEQ ID n~296 sp|P03822 |YDIA_ECOLI HYPOTHETICAL 31.2 KDA

PROTEIN IN PPSA-AROH INTERGENIC REGION

Contig9 from pir| IQQECAD probable membrane protein ydiA - SEQ ID n° 6241 PL-1230.1 431037 to m 79% Escherichia coli gb| AC74773. l| (AE000265) orf,

431918 hypothetical protein [Escherichia coli K12] gb|AAG56690.l|AE005393_7 (AE005393) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~298

TABLEAU II

s I 23538 | PPSA_ECOLI PHOSPHOENOLPYRUVATE

SYNTHASE (PYRUVATE, ATER DIKINASE) (PEP

SYNTHASE) pir||S20554 pyruvafe.water dikinase

(EC 2.7.9.2) ppsA [validated] - Escherichia

Contig9 from coli emb|CAA42024.1 | (X59381) pyruvate,water SEQ ID n° 6242 PL-1231.1 432131 to p 903 dikinase [Escherichia coli] dbj |BAA15471.l|

434509 (D90813) Pyruvate, ater dikinase (EC 2.7.9.2) [Escherichia coli] gb|AAC74772.l| (AE000265) phosphoenolpyruvate synthase [Escherichia coli

K12] SEQ ID n~299

Contig9 from gb|AAG56675.l|AE005392_l (AE005392) orf, SEQ ID n° 6243 PL-1232.1 434954 to m 77% hypothetical protein [Escherichia coli 0157 :H7]

436063 SEQ ID n~S00 Contig9 from gb|AAG56674.l|AE005391_ll (AΞ005391) putative SEQ ID n° 6244 PL-1233.1 436420 to p 85% oxidase [Escherichia coli 0157 :H7]

439479 SEQ ID n~301 pir||F64926 conserved hypothetical protein bl686

Contig9 from - Escherichia coli dbj |BAA15452.1 | (D90811) SEQ ID n^» 6245 PL-4495.1 439476 to p 76% comA operon protein . [Escherichia coli]

439892 gb|AAC74756.l| (AE000263) orf, hypothetical protein [Escherichia coli K12] #N/A pir| |A82488 hypothetical protein VCA0199

Contig9 from

[imported] - Vibrio cholerae (group SEQ ID n° 6246 PL-1235.1 440678 to p 26%

01 strain N16961) gb[AAF96112.l| (AE004360)

441760 hypothetical protein [Vibrio cholerae] SEQ ID n~302

Contig9 from emb |CAC17124. l| (AJ301654) SufA protein SEQ ID n° 6247 PL-3816.1 444152 to p 62% [Pectobacterium chrysanthemi]

444532 SEQ ID n~ 993 Contig9 from emb|CAC17125.l| (AJ301654) SufB protein SEQ ID n° 6248 PL-1236.1 444545 to p 91% [Pectobacterium chrysanthemi]

446041 SEQ ID n~303 Contig9 from gblAAG56669.l|AE005391_6 (AE005391) putative ATP' SEQ ID n° 6249 PL-1237.1 446099 to p 83% binding component of a transport system

446845 [Escherichia coli 0157 :H7] SEQ ID n~304

TABLEAU II

Contig9 from emb|CAC17127.l| (AJ301654) SufD protein SEQ ID n° 6250 PL-1238.1 446820 to 68% [Pectobacterium chrysanthemi]

448136 SEQ ID n~305 Contig9 from emb|CAC17128.l| (AJ301654) cysteine desulfurase SEQ ID n° 6251 PL-1239.1 448133 to 793 [Pectobacterium chrysanthemi]

449371 SEQ ID n-306 Contig9 from emb|CAC17129.l| (AJ301654) SufE protein SEQ ID n° 6252 PL-4491.1 449409 to 70% [Pectobacterium chrysanthemi]

449825 #N/A Contig9 from gb|AAG55859-.J.|AE005321_2 (AE005321) orf, SEQ ID n° 6253 PL-1240.1 449947 to 583 hypothetical protein [Escherichia coli 0157 :H7]

451029 SEQ ID n~308 sp|P02939|MULI_ERWAM MAJOR OUTER MEMBRANE

Contig9 from LIPOPROTEIN PRECURSOR (MUREIN-LIPOPROTEIN) SEQ ID n° 6254 PL-4490.1 451140 to m 753 pir| |NPWCWY murein-lipoprotein precursor -

451376 Erwinia amylovora gb| AAA24824.1 | (J01577) lipoprotein [Erwinia amylovora] #N/A pir| |G83418 probable enoyl-CoA hydratase/isomerase PA1821 [imported] -

Contig9 from

Pseudomonas aeruginosa (strain PAOl) SEQ ID n° 6255 PL-1241.1 451818 to 523 gb | AAG05210 . l ] AE004608_9 (AE004608) probable

452669 enoyl-CoA hydratase/isomerase [Pseudomonas aeruginosa] SEQ ID n~309

Contig9 from sp|P77983|KPYl_SALTY PYRUVATE KINASE I (PK-1) SEQ ID n° 6256 PL-1243.1 452922 to 933 emb|CAA68205.l| (X99945) pyruvate kinase like

454331 protein [Salmonella typhimurium] SEQ ID n~Sll Contig9 from SEQ ID n° 6257 PL-4488.1 454338 to m No Hits found

454673 #N/A Contig9 from SEQ ID n° 6258 PL-7250.1 454793 to No Hits found

454903 #N/A Contig9 from gb|AAG56652.l|AE005389_8 (AE005389) putative SEQ ID n° 6259 PL-1244.1 455280 to 833 transport protein [Escherichia coli 0157 :H7]

456653 SEQ ID n~312

TABLEAU II

c_i._|r- 9015|RISA_ECOLI RIBOFLAVIN SYNTHASE ALPHA

CHAIN pir||S28526 riboflavin synthase (EC

2.5.1.9) alpha chain - Escherichia coli emb[CAA48861.l| (X69109) riboflavin synthase

[Escherichia coli] gb| AAB47940.1 [ (U68703)

Contig9 from riboflavin synthase, alpha chain [Escherichia SEQ ID n° -6260 PL-1245.1 456880 to 773 coli] dbj |BAA15429.l| (D90809) Riboflavin

457557 synthase a chain (EC 2.5.1.9) . [Escherichia coli] dbj |BAA15438.l| (D90810) Riboflavin synthase a chain (EC 2.5.1.9) . [Escherichia coli] gb|AAC74734.l| (AE00026I) riboflavin synthase, alpha chain [Escherichia coli K12] SEQ ID n~313

Contig9 from

SEQ ID n° 6261 PL-4487.1 457766 to No Hits found

457879 #N/A

Contig9 from

SEQ ID n° 6262 PL-1246.1 457964 to No Hits found

458941 SEQ ID n~314

Contig9 from gb|AAG56650.l|AΞ005389_6 (AE005389) cyclopropane

SEQ ID n° 6263 PL-1247.1 459245 to m fatty acyl phospholipid synthase

460396 [Escherichia coli 0157 :H7] SEQ ID n~315

Contig9 from gb|AAG56649.l|AE005389_5 (AE005389) putative

SEQ ID n° 6264 PL-1248.1 460817 to m 61% transport protein [Escherichia coli 0157 :H7]

462115 SEQ ID n~316 sp | P37598 | YDHB_EC0LI HYPOTHETICAL

TRANSCRIPTIONAL REGULATOR IN PURR-CFA INTERGENIC

REGION pir] |E64923 probable transcription

Contig9 from regulator ydbH - Escherichia coli

SEQ ID n° 6265 PL- 1249.1 462285 to 793 gb|AAC74731.l| (AE000261) putative

463193 transcriptional regulator LYSR-type

[Escherichia coli K12] gb| AAG56648.1 | E005389_4

(AE005389) putative transcriptional regulator LYSR-type [Escherichia coli 0157 -.H7] SEQ ID n~317

TABLEAU II

_i=_fc wo3446|PURR_SALT PURINE NUCLEOTIDE SYNTHESIS

Contig9 from

REPRESSOR gb |AAC05741.1 | (AF040636) purine SEQ ID n° 6266 PL-1250.1 463200 to nucleotide synthesis repressor [Salmonella

- 464225 typhimurium] SEQ ID n~319

Contig9 from SEQ ID n° 6267 PL-4486.1 464411 to m No Hits found

464545 #N/A sp|P37010|YDHD_ECOLI 12.9 KDA PROTEIN IN LHR-

SODB INTERGENIC REGION pir| |H64922 probable glutaredoxin-like protein ydhD - Escherichia coli^"- dbj |BAA15420.l| (D90809) ORF_ID :o317#10 ;

Contig9 from similar to [SwissProt Accession Number SEQ ID n° 6268 PL-3815.1 464808 to 663

P37010] [Escherichia coli] gb |AAC74726.1 |

465158

(AE000260) orf, hypothetical protein

[Escherichia coli K12] gb|AAG56643.l|AE005388_8

(AE005388) orf, hypothetical protein

[Escherichia coli 0157 :H7] SEQ ID n-2992 sp|P30014|RNT_ECOLI RIBONUCLEASE T

(EXORIBONUCLEASE T) (RNASE T) pir| |A45065

Contig9 from ribonuclease T (EC 3.1.13.-) rnt - Escherichia SEQ ID n° 6269 PL-1251.1 465385 to 813 coli gb|AAC37008.l| (L01622) RNaseT

466038

[Escherichia coli] gb |AAC74724. l| (AE000260)

RNase T, dégrades tRNA [Escherichia coli K12] SEQ ID n-320

TABLEAU II

_{& l}v59384|LGUL_EC0LI LACTOYLGLUTATHIONE LYASE

(METHYLGLYOXALASE) (ALDOKETOMUTASE)

(GLYOXALASE I) (GLX I) (KΞTONE-ALDEHYDE MUTASE)

(S-D-LACTOYLGLUTATHIONE METHYLGLYOXAL LYASE) pir] |E64922 lactoylglutathione lyase (EC

4.4.1.5) gloA - Escherichia coli pdb|lF9z|A

Chain A, Crystal structure Of^'The Ni (Ii) -Bound

Glyoxalase I From Escherichia Coli pdb|lF9Z|B Chain B, Crystal Structure Of The

Contig9 from Ni (ii) -Bound Glyoxalase I From SEQ ID n° 6270 PL-3814.1 466038 to m 74? Escherichia Coli pdb|lFA5|A Chain A, Crystal

466451 Structure Of The Zn(Ii) -Bound Glyoxalase I of Escherichia Coli pdb|lFA5|B Chain B, Crystal Structure Of The Zn(Ii) -Bound Glyoxalase I Of Escherichia Coli pdb[lFA6|A Chain A, Crystal Structure Of The Co(Ii) -Bound Glyoxalase I Of Escherichia Coli pdb|lFA6|B Chain B, Crystal Structure Of The Co(Ii) -Bound Glyoxalase I Of Escherichia Coli pdb|lFA7|A Chain A, Crystal

Structure Of Cd(li) -Bound Glyoxalase I Of Escherichia Coli pdb|lFA7|B Chain B, Crystal SEQ ID n~2991

Contig9 from gb|AAG56637.l|AE005388_2 (AE005388) orf,

SEQ ID n° 6271 PL-4485.1 466621 to 703 hypothetical protein [Escherichia coli 0157 :H7]

466863 #N/A

Contig9 from gb|AAK01704.l|AF330139_l (AF330139)

SEQ ID n° 6272 PL-4484.1 467424 to transcriptional activator RovA [Yersinia

467855 pseudotuberculosis] #N/A

Contig9 from gb|AAD50821.l|AF168687_2 (AF168687) outer

SEQ ID n° 6273 PL-3813.1 467940 to m 713 membrane lipoprotein Pep [Pectobacterium

468410 carotovorum subsp. carotovorum] SEQ ID n~2990

Contig9 from gb|AAG56629.l|AΞ005387_7 (AΞ005387) orf,

SEQ ID n° 6274 PL-3009.1 468752 to p 803 hypothetical protein [Escherichia coli 0157 :H7]

469870 SEQ ID n~2240

TABLEAU II

&p I r- 8225 | PDXH_ECOLI PYRIDOXAMINE 5 ' -PHOSPHATE

OXIDASE (PNP/PMP OXIDASE) (PNPOX) pir| |B43261 pyridoxamine-phosphate oxidase (EC 1.4.3.5) pdxH

- Escherichia coli pdb|lG76|A chain A, X-Ray

Structure Of Escherichia Coli Pyridoxine

5 ' -Phosphate Oxidase Complexed with Pyridoxal

Contig9 from ^~5^*"' -Phosphate At 2.0 A Resolution pdb| 1G79|A^{~ "} SEQ ID n° 6275 PL-3008.1 469920 to 82% Chain A, X-Ray structure Of Escherichia Coli

470573 Pyridoxine 5 ' -Phosphate Oxidase

Complexed With Pyridoxal 5 '-Phosphate

At 2.0 A Resolution gb| AAA24709.l| (M92351) pyridoxamine phosphate oxidase [Escherichia

COli] gb|AAC74710.l| (AE000259) pyridoxinephosphate oxidase [Escherichia coli

K12] SEQ ID n~2239

Contig9 from gb|AAG56626.l|AΞ005387_4 (AE005387) tyrosine SEQ ID n° 6276 PL-3007.1 470694 to p 89% tRNA synthetase [Escherichia coli 0157 :H7]

471968 SEQ ID n~2238 Contig9 from sp|Q51892|PDXY_PROMI PYRIDOXAMINE KINASE (PM SEQ ID n° 6277 PL-3006.1 472282 to p 84% KINASE)

473145 SEQ ID n~2237 sp|P15 14|GT_PR0MI GLUTATHIONE S-TRANSFERASE GST-

6.0 (GST Bl-1) pir||S29772 glutathione transferase (EC 2.5.1.18) - Proteus mirabilis pir||S71882 glutathione transferase (EC

2.5.1.18) Bl-1 - Proteus mirabilis pdb|lPMT|

Glutathione Transferase From Proteus Mirabilis

Contig9 from pdb|2PMT|A Chain A, Glutathione Transferase From

SEQ ID n° 6278 PL-3005.1 473242 to m 723

Proteus Mirabilis pdb|2PMT|B Chain B,

473847

Glutathione Transferase From Proteus Mirabilis pdb|2PMT|c chain c, Glutathione Transferase From

Proteus Mirabilis pdb|2PMT|D Chain D,

Glutathione Transferase From Proteus Mirabilis gb|AAC44362.l| (U38482) glutathione transferase

[Proteus mirabilis] SEQ ID n~2236

TABLEAU II

Contig9 from SEQ ID n° 6279 PL-3004.1 474341 to m No Hits found

475099 SEQ ID n~2235 sp | 16657 | FABI_SALTY ENOYL- [ACYL-CARRIER- PROTEIN] REDUCTASE [NADH] (NADH-DEPENDENT

Contig9 from ENOYL-ACP REDUCTASE) pir||B43729 enoyl- [acyl- SEQ ID n° 6280 PL-3003.1 475534 to m 883 carrier-protein] reductase (NADH) (EC 1.3.1.9) -

476322 Salmonella typhimurium gb|AAA27059. l| (M31806) envM protein [Salmonella typhimurium] SEQ ID n~2234 sp|P36638|SAPF_SALTY PEPTIDE TRANSPORT SYSTEM ATP-BINDING- ROTEIN SAPF pir||S39589 peptide

Contig9 from transport system ATP-binding protein sapF - SEQ ID n° 6281 PL-3002.1 476497 to m 91% Salmonella typhimurium

477306 emb|CAA52288.l| (X74212) sapF [Salmonella typhimurium] SEQ ID n~2233

Contig9 from emb|CAA10912.l| (AJ222649) sapD [Erwinia SEQ ID n° 6282 PL-3001.1 477307 to m 87% chrysanthemi]

478299 SEQ ID n~2232 Contig9 from gb|AAG56512.l|AE005377_5 (AE005377) homolog of SEQ ID n° 6283 PL-3000.1 478299 to 823 Salmonella peptide transport permease protein

479189 [Escherichia coli 0157 :H7] SEQ ID n~2231 sp|P36668|SAPB_SALTY PEPTIDE TRANSPORT SYSTEM

PERMEASE PROTEIN SAPB pir||S39586 peptide

Contig9 from transport system permease protein sapB - SEQ ID n° 6284 PL-2999.1 479176 to 913

Salmonella typhimurium

480141 emb|CAA52285.l| (X74212) sapB [Salmonella typhimurium] SEQ ID n-2227 sp|Q47622|SAPA_ECOLI PEPTIDE TRANSPORT

PERIPLASMIC PROTEIN SAPA PRECURSOR pi | |A6 878 peptide transport periplasmic protein sapA

Contig9 from precursor - Escherichia coli SEQ ID n° 6285 PL-2998.1 480138 to m 813 emb|CAA65937.l| (X97282) SapA protein

481802 [Escherichia coli] gb |AAC74376.1 | (AΞ000227) homolog of Salmonella peptide transport periplasmic protein [Escherichia coli

K12] SEQ ID n~2226

TABLEAU II

Contig9 from gb|AAG22112.l| (AY008264) phage shock protein F SEQ ID n° 6286 PL-2997.1 482060 to m 84% [Yersinia enterocolitica]

483082 SEQ ID n~2225 Contig9 from gb|AAG22113.l| (AY008264) phage shock protein A SEQ ID n° 6287 PL-2996.1 483246 to 85% [Yersinia enterocolitica]

483920 SEQ ID n~2224 sp|P23854|PSPB_ΞC0LI PHAGE SHOCK PROTEIN B pir||si7122 phage shock protein B - Escherichia coli emb]CAA40790.l| (X57560) pspB protein

[Escherichia coli] dbj |BAA14874.l| (D90768)

Contig9 from Phage shock protein B [Escherichia coli] SEQ ID n° 6288 PL-4481.1 483957 to 76% dbj |BAA14882.l| (D90769) Phage shock protein B

484175 [Escherichia coli] gb|AAC74387.ι| (AE000228) phage shock protein [Escherichia coli K12] gb|AAG56499.l|AE005376_4 (AE005376) phage shock protein, putative inner membrane protein

[Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG22H5.l| (AY008264) phage shock protein c SEQ ID n° 6289 PL-4480.1 484175 to p 783 [Yersinia enterocolitica]

484528 #N/A Contig9 from gb|AAG22ll7.l| (AY008264) hypothetical protein SEQ ID n° 6290 PL-2995.1 484595 to p 873 YcjX [Yersinia enterocolitica]

485992 SEQ ID n~2223 Contig9 from gb|AAG22118.l] (AY008264) hypothetical protein SEQ ID n° 6291 PL-2994.1 "485989 to p 823 YcjF [Yersinia enterocolitica]

487053 SEQ ID n~2222 Contig9 from sp|Q9ZIB7]TYRR_ERWHE TRANSCRIPTIONAL REGULATORY SEQ ID n° 6292 PL-2993.1 487310 to p 773 PROTEIN TYRR gb | AD02000.1 | (AF035010)

488893 regulatory protein TyrR [Erwinia herbicola] SEQ ID n~2221

TABLEAU II

sp|i-j790l|TPX_ECOLI THIOL PEROXIDASE (SCAVΞNGASE

P20) sp|P57669|TPX_SHIDY THIOL PEROXIDASE pir| | JC5504 thioredoxin peroxidase (EC 1.11.1.-)

- Escherichia coli gb | AAC74406.1 | (AE000230)

Contig9 from thiol peroxidase [Escherichia coli K12] SEQ ID n° 6293 PL-2992.1 488931 to m 713 gb|AAC45284.l| (U93212) scavengase p20

489434 [Escherichia coli] gb|AAF28i34.l |AF153317_31

(AF153317) thiol peroxidase [Shigella dysenteriae] gb|AAG56478.l|AE005374_l

(AEO 05 74) thiol peroxidase [Escherichia coli

0157 :H7] SEQ ID n~2220 pir| ]D64882 periplasmic oligopeptide-binding protein precursor - Escherichia coli dbj |BAA14922.1 | (D90771) Periplasmic oligopeptide-binding protein precursor.

Contig9 from

[Escherichia coli] dbj |BAA1 932.1 | (D90772) SEQ ID n° 6294 PL-2991.1 489608 to 733

Periplasmic oligopeptide-binding protein

491230 precursor. [Escherichia coli] gb|AAC744ll.l| (AE000231) putative transport periplasmic protein [Escherichia coli

K12] SEQ ID n~2219

Contig9 from gb|AAG40855.l|AF308568_2 (AF308568) zinc SEQ ID n° 6295 PL-2990.1 491247 to 723 transport protein [Salmonella typhimurium]

492230 SEQ ID n~2218 Contig9 from SEQ ID n° 6296 PL-4477.1 492309 to m No Hits found

492533 #N/A sp|P76055|YDAO_ECOLI HYPOTHETICAL 35.6 KD

Contig9 from PROTEIN IN DBPA-INTR INTERGENIC REGION SEQ ID n° 6297 PL-2989.1 492742 to m 893 pir( |C64884 ydaO protein - Escherichia coli

493662 gb|AAC74426.l| (AE000232) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~2216

Contig9 from SEQ ID n° 6298 PL-4476.1 493802 to No Hits found

493984 #N/A

TABLEAU II

Contig9 from SEQ ID n° 6299 PL-3812.1 495338 to m No Hits found

495802 SEQ ID n~2989 Contig9 from SEQ ID n° 6300 PL-3811.1 495953 to m No Hits found

496366 SEQ ID n~2988 Contig9 from SEQ ID n° 6301 PL-2988.1 497075 to No Hits found

498082 SEQ ID n~2215 Contig9 from gb]AAG54517.l| AEO0.5197_6 (AE005197) Z0248 gène SEQ ID n° 6302 PL-3809.1 498483 to 653 product [Escherichia coli 0157 :H7]

498962 SEQ ID n~2986 Contig9 from SEQ ID n° 6303 PL-4474.1 499298 to m No Hits found

499432 #N/A ref |NP_044260.l| QacΞ [Enterobacter aerogenes] sp|Q57225|QACE_ΞCOLI QUATERNARY AMMONIUM

COMPOUND-RESISTANCE PROTEIN QACE (QUARTERNARY

AMMONIUM DETERMINANT E) pir| [A48905 small multidrug export protein qacE [validated] -

Contig9 from Klebsiella pneumoniae pir] |T08519 SEQ ID n° 6304 PL-4473.1 499813 to P 81% small multidrug export protein qacE -

500145 Enterobacter aerogenes plasmid R751 emb |CAA483 ll.l | (X68232) multiresistance protein

[Klebsiella aerogenes] emb| CAA51179.l] (X72585) multidrug exporter [Klebsiella aerogenes] gb|AAC64463.l| (U67194) QacE [Enterobacter aerogenes] #N/A

Contig9 from sp|P52646|YDBJ_ECOLI HYPOTHETICAL 8.7 KDA SEQ ID n° 6305 PL-4472.1 500199 to 29% PROTEIN IN OMPN-HSLJ INTERGENIC REGION

500516 PRECURSOR #N/A gb|AAG56036.l|AE005335_9 (AE005335) reoxidi-zes

Contig9 from

DsbA protein following formation of disulfide SEQ ID n° 6306 PL-3808.1 500768 to 733 bond in P-ring of flagella. [Escherichia coli

501277

0157:H7] SEQ ID n~2985

TABLEAU II

_OJ^_|P27377|NHAB_EC0LI NA(+)/H(+) ANTIPORTER 2

(SODIUM/PROTON ANTIPORTER 2) pir| |G64864 Na+/H+' exchanging protein nhaB - Escherichia coli

Contig9 from dbj |BAA36033.1| (D90752) Na+/H+ antiporter

SEQ ID n° 6307 PL-2987.1 501459 to m 813 protein nhaB [Escherichia coli] dbj ]BAA36041.1 |

503006 (D90753) Na+/H+ antiporter protein nhaB

[Escherichia coli] gb|AAC74270.l| (AE000217)

Na+/H+ antiporter, pH independent [Escherichia coli K12] SEQ ID n~2214

Contig9 from pdb|lE2X|A Chain A, Fadr, Fatty Acid Responsive

SEQ ID n° 6308 PL-2986.1 503229 to 823 Transcription Factor From E. Coli

503948 SEQ ID n~2213 sp|P29011|DADA_ECOLI D-AMINO ACID DEHYDROGENASE

SMALL SUBUNIT pir| |B53383 D-amino-acid dehydrogenase (EC 1.4.99.1) small chain -

Escherichia coli gb| AC36880.1 |

(L02948) D-amino acid dehydrogenase [Escherichia

Contig9 from coli] dbj |BAA36044.l| (D90753) D-amino acid

SEQ ID n° 6309 PL-2985.1 504469 to 76% dehydrogenase small subunit (EC 1.4.99.1).

505782

[Escherichia coli] gb| AAC74273.l| (AE000217) D- amino acid dehydrogenase subunit [Escherichia coli K12] gb|AAG56040.l|AE005336_l

(AE005336) D-amino acid dehydrogenase subunit

[Escherichia coli 0157 :H7] SEQ ID n~2212

Contig9 from gb|AAC61705.l] (AF081283) alanine racemase SEQ ID n° 6310 PL-2984.1 505789 to p 75%

[Escherichia coli]

506877 SEQ ID n~2211

Sp|P77486|MIPA_ECOLI MLTA-INTERACTING PROTEIN

PRECURSOR pir| |F64938 hypothetical protein bl782 - Escherichia coli (strain K-12)

Contig9 from dbj |BAA15583.l| (D90822) Outer membrane protein SEQ ID n° 6311 PL-2983.1 507222 to p 62% precursor. [Escherichia coli] dbj |BAA15579.1 |

507974

(D90821) Outer membrane protein precursor.

[Escherichia coli] gb| AAC7485 .1 | (AE000273) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~2210

TABLEAU II

sp| PU6977 |G3P1_EC0LI GLYCERALDEHYDE 3-PHOSPHATE

DEHYDROGENASE A (GAPDH-A) pir| ]DEECG3 glyceraldehyde-3 -phosphate dehydrogenase (EC

1.2.1.12 ) A - Escherichia coli emb|CAA26498.l| (X02662) put. GAPDH (aa 1-332)

Contig9 from [Escherichia coli] dbj |BAA15576. l| (D90821) SEQ ID n° 6312 PL-2982.1 508075 to m 81% Glyceraldehyde-3 -phosphate dehydrogenase (EC

509070 1.2.1.12) A [Escherichia coli] gb|AAC74849.l| (AE000273) glyceraldehyde-3 - phosphate dehydrogenase A [Escherichia coli K12] gb|AAG56768.l|AE005401_3 (AE005401) glyceraldehyde-3 -phosphate dehydrogenase A

[Escherichia coli 0157 :H7] SEQ ID n~2209 sp]P39903|YEAA_ΞCOLI HYPOTHETICAL 15.5 KDA

PROTEIN IN ANSA-GAPA INTERGENIC REGION pir| |B64938 hypothetical protein bl778 -

Contig9 from

Escherichia coli (strain K-12) gb|AAC74848 ,l| SEQ ID n° 6313 PL-3806.1 509540 to p 68%

(AEO 00272) orf, hypothetical protein

509950

[Escherichia coli K12] gb| AG56767.1 | AE005401_2

(AE005401) orf, hypothetical protein

[Escherichia coli 0157 :H7] SEQ ID n~2984

Contig9 from gb|AAG56766.l|AE005401_l (AE005401) Z2816 gène SEQ ID n° 6314 PL-4469.1 510033 to p 69% product [Escherichia coli 0157 :H7]

510302 #N/A Contig9 from gb|AAG56755.l]AE005399_9 (AE005399) orf, SEQ ID n° 6315 PL-2981.1 510366 to m 65% hypothetical protein [Escherichia coli 0157 :H7]

511004 SEQ ID n~2208 sp|P18840|ASGl_ECOLI L-AS ARAGINASE I (L-

ASPARAGINE AMIDOHYDROLASE I) (L-ASNASE I) pir] |XDΞC1 asparaginase (EC 3.5.1.1) I -

Contig9 from

Escherichia coli dbj |BAA15558. l| (D90820) L- SEQ ID n° 6316 PL-2980.1 511017 to m 82= asparaginase I (EC 3.5.1.1) (L-asparagine

512036 amidohydrolase I) . [Escherichia coli] gb|AAC74837.l| (AEO 00271) cytoplasmic L- asparaginase I [Escherichia coli K12] SEQ ID n~2207

TABLEAU II

pir| |PRECT4 proteinase IV (EC 3.4.-.-) -

Escherichia coli dbj |BAA15557. l| (D90820)

Contig9 from

Proteinase IV (EC 3.4.-.-) [Escherichia coli] SEQ ID n° 6317 PL-2979.1 512286 to 723 gb]AAC74836.l| (AE000271) protease IV, a signal

514151 peptide peptidase [Escherichia coli

K12] SEQ ID n~2205 sp|P24250 |YDJA_ECOLI PROTEIN YDJA pir] |A40360 hypothetical protein, 20K (selD-sppA intergenic région) - Escherichia coli gb|AAA24245.l| (M68961) ORF183 [Escherichia

Contig9 from . coli] dbj ]BAA15556.l| (D90820) ORF_ID:o329# ;

SEQ ID n° 6318 PL-3805.1 514322 to 713 similar to [PIR Accession Number A40360] 514873

[Escherichia coli] gb |AAC74835.1 | (AE000271) orf, hypothetical protein [Escherichia coli K12] gb|AAG56751.l|AE005399_5 (AE005399) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~2983 sp | 16456 | SELD_ECOLI SELENIDΞ, WATER DIKINASE

(SELENOPHOSPHATE SYNTHETASE) (SELENIUM DONOR PROTEIN) pir| | JW0033 selenophosphate synthase - Escherichia coli gb| AAA74748. l|

(M30184) sélénium metabolism protein

Contig9 from

[Escherichia coli] dbj |BAA15555. l| (D90820) SEQ ID n° 6319 PL-2978.1 514886 to 83?

Selenide, ater dikinase (EC 2.7.9.3)

515929

(Selenophosphate synthetase)

(Sélénium donor protein) . [Escherichia coli] gb|AAC74834.l| (AE000271) selenophosphate synthase, H(2)Se added to acrylyl-tRNA

[Escherichia coli K12] SEQ ID n~2204

TABLEAU II

sp|P14 94|T0P3_EC0LI DNA TOPOISOMERASE III pir] | V0049 DNA topoisomerase (EC 5.99.1.2) III

Escherichia coli pdb|lD6M|A Chain A, Crystal

Structure Of E. Coli Dna Topoisomerase lii

Contig9 from gb|AAA83923.l| (J05076) topoisomerase III

SEQ ID n° 6320 PL-2977.1 515935 to 873 [Escherichia coli] dbj |BAA15551.l| (D90819) DNA

517863 topoisomerase III (EC 5.99.1.-) [Escherichia coli] dbj |BAA15554.l| (D90820) DNA topoisomerase III (EC 5.99.1.-) [Escherichia coli] gb|AAC74833.l| (AΞ000271) DNA topoisomerase III [Escherichia coli K12] SEQ ID n~2203 sp|P09030|EX3_ECOLI EXODEOXYRIBONUCLEASE III

(EXONUCLEASE III) (ΞXO III) (AP

ENDONUCLEASE VI) pir| | NCECX3 exodeoxyribonuclease III (EC 3.1.11.2) -

Escherichia coli pdb | 1AKO | Exonuclease lii

Contig9 from From Escherichia coli emb |CAA31424. ι| (X13002)

SEQ ID n° 6321 PL-2976.1 517921 to 883 exonuclease III [Escherichia coli]

518727 dbj |BAA15540.l| (D90818) Exodeoxyribonuclease

III (EC 3.1.11.2) [Escherichia coli] dbj |BAA15544.l| (D90819) Exodeoxyribonuclease

III (EC 3.1.11.2) [Escherichia coli] gb|AAC74819.l| (AE000270) exonuclease III

[Escherichia coli K12] SEQ ID n~2202

Contig9 from emb|CAA10420. l| (AJ131559) rlsA protein [Erwinia

SEQ ID n° 6322 PL-2975.1 519230 to 323 amylovora]

520093 SEQ ID n~2201

Contig9 from

SEQ ID n° 6323 PL-4467.1 520362 to m No Hits found

520646 #N/A

Contig9 from

SEQ ID n° 6324 PL-4466.1 520697 to m No Hits found

520903 #N/A

Contig9 from

SEQ ID n° 6325 PL-4465.1 520965 to m No Hits found

521186 #N/A

TABLEAU II

Contig9 from SEQ ID n° 6326 PL-4463.1 522084 to p No Hits found

522335 #N/A Contig9 from SEQ ID n° 6327 PL-2974.1 522412 to p No Hits found

522996 SEQ ID n~2200 Contig9 from SEQ ID n° 6328 PL-4461.1 523105 to p No Hits found

Contig9 from gb|AAG53985.l|AF327444_l (AF327444) putative SEQ ID n° 6329 PL-4460.1 523412 to p 75% transposase A [Erwinia herbicola]

523858 #N/A Contig from gb|AAG53986.l|AF327444_2 (AF327444) putative SEQ ID n° 6330 PL-3804.1 523855 to p 77% transposase B [Erwinia herbicola]

524250 SEQ ID n~2982 Contig9 from SEQ ID n° 6331 PL-2973.1 524619 to No Hits found

525389 SEQ ID n~2199 Contig9 from SEQ ID n° 6332 PL-4459.1 525423 to p No Hits found

525704 #N/A pir] ]D82455 hypothetical protein VCA0468

Contig9 from

[imported] - Vibrio cholerae (group SEQ ID n° 6333 PL-4457.1 525843 to 613

Ol Strain N16961) gb|AAF96372.l| (AE004379)

526154 hypothetical protein [Vibrio cholerae] #N/A pir||E82455 conserved hypothetical protein

Contig9 from VCA0469 [imported] - Vibrio cholerae SEQ ID n° 6334 PL-4456.1 526157 to 46° (group 01 strain N16961) gb|AAF96373. l|

526447 (AΞ004379) conserved hypothetical protein

[Vibrio cholerae] #N/A

Contig9 from SEQ ID n° 6335 PL-2972.2 526810 to m No Hits found

527403 #N/A Contig9 from SEQ ID n° 6336 PL-4455.1 527865 to m No Hits found

528209 #N/A

TABLEAU II

Contig9 from

SEQ ID n° 6337 PL-2934.1 528738 to m No Hits found

529331 SEQ ID n~2156

Contig9 from

SEQ ID n° 6338 PL-4043.2 530038 to No Hits found

530487 #N/A

Contig9 from emb|CAB77347.l| (AL160331) hypothetical protein

SEQ ID n° 6339 PL-2933.2 530540 to 33% SCD8A.26c [Streptomyces coelicolor

531661 A3 (2)] #N/A

Contig9 from emb | CAB77347 . l | (AL160331) hypothetical protein

SEQ ID n° 6340 PL-2932.1 531673 to 21% SCD8A.26C [Streptomyces coelicolor

533079 A3 (2 ) ] SEQ ID n-2154

Contig9 from emb | CAB77347 . l ( (AL160331) hypothetical protein

SEQ ID n° 6341 PL-2931.1 533128 to 32% SCD8A.26c [Streptomyces coelicolor

534324 A3 (2) ] SEQ ID n-2153

Contig9 from

SEQ ID n° 6342 PL-4041.1 534338 to No Hits found

534796 SEQ ID n~3190

Contig9 from

SEQ ID n° 6343 PL-4451.1 534793 to No Hits found

pir| [F82511 vgrG protein VCA0018 [imported] -

Contig9 from

Vibrio cholerae (group 01 strain

SEQ ID n° 6344 PL-2929.1 535639 to 133

N16961) gb]AAF95932.l| (AE004345) vgrG protein

537240

[Vibrio cholerae] SEQ ID n~2151

Contig9 from emb|CAB77339.l| (AL160331) hypothetical protein

SEQ ID n° 6345 PL-4449.1 537254 to 43% SCD8A.18C [Streptomyces coelicolor

537670 A3 (2)] #N/A

Contig9 from

SEQ ID n° 6346 PL-4448.1 537667 to No Hits found

538083 #N/A

Contig9 from

SEQ ID n° 6347 PL-2928.1 538166 to No Hits found

540895 SEQ ID n~2150

TABLEAU II

Contig9 from

SEQ ID n° 6348 PL-2927.2 540888 to p No Hits found

543791 #N/A

Contig9 from pir||JQ1866 hypothetical 87.1K protein - bovine

SEQ ID n° 6349 PL-2926.2 543919 to 203 adenovirus 3

545175 #N/A

Contig9 from

SEQ ID n° 6350 PL-2925.1 545234 to No Hits found

547093 SEQ ID n~2147

Contig9 from emb|CAB77353.l[ (AL160331) putative AAA family

SEQ ID n° 6351 PL-2924.1 547103 to 23% ATPase [Streptomyces coelicolor

549187 A3 (2)] SEQ ID n~2146

Contig9 from emb|CAB77354.l| (AL160331) hypothetical protein

SEQ ID n° 6352 PL-2923.1 549212 to 253 SCD8A.33c (fragment) [Streptomyces

550108 coelicolor A3 (2)] SEQ ID n~2145

Contig9 from

SEQ ID n° 6353 PL-2922.1 550237 to No Hits found

551178 SEQ ID n~2144

Contig9 from

SEQ ID n° 6354 PL-2921.1 551617 to No Hits found

552762 SEQ ID n~ 143

Contig9 from gb|AAK03443.l| (AE006173) GntP [Pasteurella

SEQ ID n° 6355 PL-2920.1 552917 to m 803 multocida]

554302 SEQ ID n~2142 sp|P44094|YA14_HAEIN HYPOTHETICAL PROTEIN HI1014

Contig9 from pir| |D64018 hypothetical protein HI1014 - SEQ ID n° 6356 PL-2919.1 554305 to 71% Haemophilus influenzae (strain Rd

555270 KW20) gb|AAC22675.l| (U32782) conserved hypothetical protein [Haemophilus influenzae Rd] SEQ ID n~2140 sp | P44978 | YGBI_HAEIN HYPOTHETICAL

Contig9 from TRANSCRIPTIONAL REGULATOR HIl009 gb | AAC22670.11 SEQ ID n° 6357 PL-2918.1 555443 to m 663 (U32781) glycerol-3 -phosphate regulon repressor

556210 (glpR) [Haemophilus influenzae Rd] SEQ ID n~2139

Contig9 from gb|AAG14970.l|AF242208_3 (AF242208) unknown SEQ ID n° 6358 PL-2917.1 556223 to m 663 [Escherichia coli]

557002 SEQ ID n~2138

TABLEAU II

s | Q46890 | GBL_ECOLI HYPOTHETICAL 23.2 KDA

PROTEIN IN PPHB-RPOS INTERGENIC REGION pir||F65054 L-fuculose-phosphate aldolase (EC

4.1.2.17) - Escherichia coli (strain

Contig9 from K-12) gb]AAA69248.l| (U29579) ORF_o212

SEQ ID n° 6359 PL-2916.1 557021 to m 613 [Escherichia coli] gb|AAC75780.l| (AE000357)

557680 putative epimerase/aldolase [Escherichia coli

K12] gb|AAG14969.l|AF242208_2 (AF242208) putative enzyme [Escherichia coli] gb|AAG14982.l|AF242210_l (AF242210) putative enzyme [Escherichia coli] SEQ ID n~2137

Contig9 from gb|AAK03449.l| (AE006174) unknown [Pasteurella

SEQ ID n° 6360 PL-2915.1 557655 to 65% multocida]

558932 SEQ ID n~2136

Contig9 from gb|AAK03450.l| (AE006174) unknown [Pasteurella

SEQ ID n° 6361 PL-2914.1 558932 to m 743 multocida]

559837 SEQ ID n~2135 ref |NP_043483.I] orf14 [Bacteriophage HP1] sp|P51716[Y014_BPHPl HYPOTHETICAL 14.9 KD

Contig9 from

PROTEIN IN REP-HOL INTERGENIC REGION (ORF14) SEQ ID n° 6362 PL-4441.1 560924 to 563 pir||S69520 hypothetical protein 14 - phage HP1

561337 gb|AAB09199.l| (U24159) orfl4 [Bacteriophage

HP1] #N/A

TABLEAU II

s | 370511 URU_ΞCOLI FORMYLTETRAHYDROFOLATE

DEFORMYLASE (FORMYL-FH (4) HYDROLASE) pir| (C36871 formyltetrahydrofolate deformylase

(EC 3.5.1.10) [validated] -

Escherichia coli gb |AAC36846. l| (L20251) formyltetrahydrofolate hydrolase [Escherichia coli] db |BAA36100.l| (D90758)

Formyltetrahydrofolate deformylase (EC 3.5.1.10)

Contig9 from

(formyl-fh(4) hydrolase) . [Escherichia coli]

SEQ ID n° 6363 PL-2913.1 561768 to m 863 dbj |BAA36112.l| (D90759) Formyltetrahydrofolate 562616 deformylase (EC 3.5.1.10) iformyl- fh(4) hydrolase) . [Escherichia coli] gb|AAC74314.l| (AE000221) formyltetrahydrofolate deformylase; for purT-dependent FGAR synthesis [Escherichia coli K12] dbj | BAA16026.1 | (D90852) FORMYLTETRAHYDROFOLATE DEFORMYLASE (EC 3.5.1.10) (FORMYL-

FH (4) HYDROLASE) . [Escherichia coli] SEQ ID n~ 134 sp|P37052|YCHJ_ECOLI HYPOTHETICAL 17.0 KDA

PROTEIN IN HNR-PURU INTERGENIC REGION pir| |D64870 ychJ protein - Escherichia coli gb|AAC74315.l| (AΞ000221) orf, hypothetical

Contig9 from protein [Escherichia coli K12] dbj |BAA16Q27.l|

SEQ ID n° 6364 PL-4039.1 562662 to m 52? (D90852) ORF_iD:o249#9~similar to [SwissProt 563141 Accession Number P37052] [Escherichia coli] dbj |BAA36101.l| (D90758) hyothetical protein (purT région) [Escherichia coli] dbj |BAA36113.l| (D90759) hyothetical protein

(purT région) [Escherichia coli] SEQ ID n~3187

TABLEAU II

sp|P37055|HNR_ECOLI HNR PROTEIN pir||A36871 37K regulator response protein homolog - Escherichia coli emb|CAA46802. l| (X66003) hnr [Escherichia coli] dbj |BAA36103.l[ (D90758) 37k regulator response protein homolog [Escherichia coli]

Contig9 from dbj |BAA36115.1 | (D90759) 37k regulator response

SEQ ID n° 6365 PL- 2912 . 1 563300 to 69^s protein homolog [Escherichia coli]

564325 gb|AAC74317.l| (AE000222) Hnr protein

[Escherichia coli K12] dbj |BAA16029.l| (D90852)

37K regulator response protein homolog

[Escherichia coli] gb| AAG56092.1 | AE005341_1

(AE005341) Hnr protein [Escherichia coli

0157.-H7] SEQ ID n~2133 s | P25520 |GALU_ECOLI UTP--GLUCOSE-1-PHOSPHATE

URIDYLYLTRANSFERASE (UDP-GLUCOSE

PYROPHOSPHORYLASE) (UDPGP) (ALPHA-D-GLUCOSYL-1-

PHOSPHATE URIDYLYLTRANSFERASE)

(URIDINE DIPHOSPHOGLUCOSE

PYROPHOSPHORYLASE) pir||JC2265 UTP--glucose-l- phosphate uridylyltransferase (EC 2.7.7.9) galU

[validated] - Escherichia coli emb] CAA42564.1 |

(X59940) ORF 1 [Escherichia coli] gb|AAA20118.1] (M98830) glucosephosphate

Contig9 from uridylyltransferase [Escherichia coli] SEQ ID n° 6366 PL-2911.1 564718 to 72% gb|AAD15244.l| (L32811) UDP-glucose

565710 pyrophosphorylase [Shigella flexneri] dbj |BAA36104.1 | (D90758) UTP-glucose-l-phosphate uridylyltransferase (EC 2.7.7.9)

[Escherichia coli] dbj | BAA36116.1 | (D90759) UTP- glucose-1-phosphate uridylyltransferase (EC

2.7.7.9) [Escherichia coli] gb|AAC74318. l| (AE000222) glucose-1-phosphate uridylyltransferase [Escherichia coli

K12] dbj |BAA16030.1| (D90852) UTP- -glucose-1- phosphate uridylyltransferase (EC 2.7.7.9)

[Escherichia coli] gb| AAG56093.l| AE005341_2 SEQ ID n~2132

TABLEAU II

pir] |B83202 probable nucleotide sugar dehydrogenase PA3559 [imported] -

Contig9 from

Pseudomonas aeruginosa (strain PAOl) SEQ ID n° 6367 PL-2910.1 565734 to p 76% gb|AAG06947.l|AE004776_10 (AΞ004776) probable

567077 nucleotide sugar dehydrogenase [Pseudomonas aeruginosa] SEQ ID n~2131

Contig9 from gb|AAD50494.l|AF172324_12 (AF172324) WbnF SEQ ID n° 6368 PL-2909.1 567086 to p 79% [Escherichia coli]

568099 SEQ ID n~2129 Contig9 from sp|P18955|HNS_SERMA DNA-BINDING PROTEIN H-NS SEQ ID n° 6369 PL-4438.1 568398 to m^" 82% (HISTONE-LIKE PROTEIN HLP-II) pir||S02775 DNA-

568802 binding protein H-NS - Serratia marcescens #N/A Contig9 from gb|AAG56095.l|AE005341_4 (AE005341) thymidine SEQ ID n° 6370 PL-2908.1 569448 to p 77% kinase [Escherichia coli θl57:H7]

570053 SEQ ID n~2128 s | P175 7 | DHE_ECOLI ALDEHYDE-ALCOHOL

DEHYDROGENASE [INCLUDES: ALCOHOL DEHYDROGENASE

(ADH) ; ACETALDEHYDE DEHYDROGENASE [ACETYLATING]

(ACDH) ; PYRUVATE-FORMATE-LYASE

DEACTIVASE (PFL DEACTIVASE) ] pir||DEEC acetaldehyde dehydrogenase (acetylating) (EC

1.2.1.10) / alcohol dehydrogenase (EC

1.1.1.1) - Escherichia coli emb|CAA4l955.l|

(X59263) alcohol dehydrogenase [Escherichia

Contig9 from coli] gb|AAA23420.l| (M33504) alcohol SEQ ID n° 6371 PL-2907.1 570296 to m 923 dehydrogenase (adhE) [Escherichia coli]

572929 dbj |BAA36l 1.l| (D90759) Alcohol dehydrogenase

(EC 1.1.1.1) . [Escherichia coli] gb|AAC74323.l| (AE000222) CoA-linked acetaldehyde dehydrogenase and iron-dependent alcohol dehydrogenase; pyruvate-formate-lyase deactivase [Escherichia coli K12] dbj |BAA16034.l| (D90852) alcohol dehydrogenase

(EC î.i.l.i) [Escherichia coli] dbj |BAA77747.I|

(AB008676) alcohol dehydrogenase [Escherichia coli] SEQ ID n~2127

TABLEAU II

Contig9 from gb|AAG56097.l|AE005341_6 (AE005341) putative SEQ ID n° 6372 PL-2906.1 573341 to p 813 channel protein [Escherichia coli 0157 :H7]

573985 SEQ ID n~ 1 6 s | P06202 | OPPA_SALTY PERIPLASMIC OLIGOPEPTIDE- BINDING PROTEIN PRECURSOR pir | | QREBOA

Contig9 from oligopeptide-binding protein precursor - SEQ ID n° 6373 PL-2905.1 574540 to 743 Salmonella typhimurium emb|CAA29039.l| (X05491)

576177 Opp A (AA1-542) [Salmonella typhimurium] etπb|CAA27785.l| (X04194) precursor polypeptide

[Salmonella typhimurium] SEQ ID n~2125 sp|P06202|θPPA_SALTY PERIPLASMIC OLIGOPEPTIDE- BINDING PROTEIN PRECURSOR pir | ] QREBOA

Contig9 from oligopeptide-binding protein precursor -

SEQ ID n° 6374 PL-2904.1 576316 to 33% Salmonella typhimurium emb |CAA29039.l| (X05491)

577956 Opp A (AA1-542) [Salmonella typhimurium] emb|CAA27785.l| (X04194) precursor polypeptide [Salmonella typhimurium] SEQ ID n~ 124 Sp|P08005 [0PPB_SALTY OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN OPPB pir||QREBOB

Contig9 from oligopeptide transport system permease protein

SEQ ID n° 6375 PL-2903.1 578041 to 93% oppB - Salmonella typhimurium

578961 emb|CAA29040.l| (X05491) Opp B (AA1-306) [Salmonella typhimurium] SEQ ID n~ 123

TABLEAU II

sp|P77664|0PPC_EC0LI OLIGOPEPTIDE TRANSPORT

SYSTEM PERMEASE PROTEIN OPPC pir] |H64871 oligopeptide transport system permease protein oppC - Escherichia coli dbj |BAA14777.l| (D90763) Oligopeptide transport

System permease protein OppC.

Contig9 from [Escherichia coli] gb|AAC743 7.l| (AE000223) SEQ ID n° 6376 PL-2902.1 578976 to 89% homolog of Salmonella oligopeptide transport

579884 permease protein [Escherichia coli

K12] dbj |BAA16040.l| (D90852) Oligopeptide transport system permease protein OppC.

[Escherichia coli] gb|AAG56100. l| AE005342_2

(AE005342) homolog of Salmonella oligopeptide transport permease protein

[Escherichia coli 0157 :H7] SEQ ID n~2122 gb[AAG56101.l|AE005342_3 (AE005342) homolog of

Contig9 from

Salmonella ATP-binding protein of SEQ ID n° 6377 PL-2901.1 579894 to 87% oligopeptide ABC transport system [Escherichia

580892 coli 0157:H7] SEQ ID n~2121 gb|AAG56102.l|AE005342_4 (AE005342) homolog Of

Contig9 from

Salmonella ATP-binding protein of SEQ ID n° 6378 PL-2900.1 580889 to 913 oligopeptide ABC transport system [Escherichia

581890 coli 0157 :H7] SEQ ID n~2120

Contig9 from gb|AAG56103.l|AE005342_5 (AE005342) Z2024 gène SEQ ID n° 6379 PL-4436.1 582019 to m 813 product [Escherichia coli 0157 :H7]

582348 #N/A Contig9 from gb|AAB60088.l| (U24197) cardiolipin synthase SEQ ID n° 6380 PL-2899.1 582460 to 843 [Escherichia coli]

583929 SEQ ID n~£117 Contig9 from SEQ ID n° 6381 PL-4434.1 584292 to No Hits found

584474 #N/A

TABLEAU II

Sp|Q05740|TONB_YEREN TONB PROTEIN pir||S30290

Contig9 from tonB protein - Yersinia enterocolitica SEQ ID n° 6382 PL-2898.1 584576 to 633 emb|CAA47747.l| (X67332) tonB [Yersinia

585256 enterocolitica] prf | | 1912295A tonB gène

[Yersinia enterocolitica] SEQ ID n~2116 sp|P04379|YCIA_ECOLI PUTATIVE ACYL-COA THIOEΞTER

HYDROLASE YCIA PRECURSOR (P14 PROTEIN) pir| |A05224 conserved hypothetical protein yciA precursor [imported] - Escherichia coli gb|AAB59067.l| (K00431) P14 protein (P14 gène; putative) ; putative [Escherichia coli] gb|AAB50068.l| (U24195) yciA gène product

[Escherichia coli] gb|AAB60076. l| (U24196) yciA gène product [Escherichia coli] gb|AAB60084.1 |

(U24197) yciA gène product [Escherichia coli]

Contig9 from gb] AAB60092.1 | (U24198) yciA gène product

SEQ ID n° 6383 PL-4037.1 585319 to m 723

[Escherichia coli] gb|AAB60100.l| (U24199) yciA

585750 gène product [Escherichia coli] gb|AAB60108.1 |

(U24200) yciA gène product [Escherichia coli] gb|AAB60116.1 | (U24201) yciA gène product

[Escherichia coli] gb|AAB60124.l| (U24202) yciA gène product [Escherichia coli] gb| AB60132. l|

(U24203) yciA gène product [Escherichia coli] gb|AAB60140.l| (U24204) yciA gène product

[Escherichia coli] gb| AAB60148. l| (U24205) yciA gène product [Escherichia coli] gb| AAB60156. l|

(U24206) yciA gène product [Escherichia coli] SEQ ID n~3186

Contig9 from pir| |T45503 hypothetical protein yciB [imported] SEQ ID n° 6384 PL-4036.1 585828 to 79% - Escherichia coli gb | AB60131.1 | (U24203) yciB

585364 gène product [Escherichia coli] SEQ ID n~3185 pir| |B82498 sulfate permease family protein

Contigg from VCA0103 [imported] - vibrio cholerae SEQ ID n° 6385 PL-2897.1 586578 to 673 (group 01 Strain N16961) gb] AAF96017.1]

588335 (AΞ004353) sulfate permease family protein

[Vibrio cholerae] SEQ ID n~ 115

TABLEAU II

sp|P16454|AIL_YΞREN ATTACHMENT INVASION LOCUS PROTEIN PRECURSOR pir | |A35123 ail protein

Contig9 from precursor - Yersinia enterocolitica SEQ ID n° 6386 PL-4035.1 588601 to 763 gb| AAA88694.l| (M29945) attach ent invasion

589146 locus protein [Yersinia enterocolitica] prf | | 1807234A ail gène

[Yersinia enterocolitica] SEQ ID n~3184 sp|P16454|AIL_YEREN ATTACHMENT INVASION LOCUS

PROTEIN PRECURSOR pir| |A35123 ail protein

Contig9 from precursor - Yersinia enterocolitica SEQ ID n° 6387 PL-4034.1 589663 to 72% gb|AAA88694.l| (M29945) attachment invasion

590190 locus protein [Yersinia enterocolitica] pr | |l807234A ail gène

[Yersinia enterocolitica] SEQ ID n~3183 pir| |B64873 probable membrane protein ycic -

Escherichia coli dbj |BAAl4787.l| (D90763)

Contig9 from

ORF_lD-.o252#13; similar to [SwissProt Accession SEQ ID n° 6388 PL-2896.1 590358 to 643

Number P21365] [Escherichia coli]

591128 gb|AAC74337.l| (AΞ000223) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~2114

Contig9 from gb|AAG56111.l|AE005343_l (AE005343) putative SEQ ID n° 6389 PL-2895.1 591559 to 713 outer membrane protein [Escherichia coli

592200 0157:H7] SEQ ID n~2113 Contig9 from emb|CAB92261.l| (AL356595) hypothetical protein SEQ ID n° 6390 PL-2894.1 592745 to m 39% [Streptomyces coelicolor A3 (2) ]

593773 SEQ ID n~2112 Contig9 from emb|cAB92258.l| (AL356595) putative repetative SEQ ID n° 6391 PL-2893.2 593766 to m 42% protein [streptomyces coelicolor

595451 A3 (2)] #N/A pir] |B82222 GTP cyclohydrolase II VC1263

Contig9 from

[imported] - Vibrio cholerae (group SEQ ID n° 6392 PL-2892.2 595464 to m 693

01 Strain N16961) gb |AAF94422.1 | (AE004205) GTP

596060 cyclohydrolase II [Vibrio cholerae] #N/A

TABLEAU II

ref |NP_073225.l| ransposase of IS630 [Salmonella enterica serovar Choleraesuis] dbj |BAA01531.1 |

Contig9 from

(D10689) M5 protein [Salmonella choleraesuis] SEQ ID n° 6393 PL-2891.2 596351 to 733 dbj |BAB20556.l| (AB040415) ransposase of IS630

597391

[Salmonella enterica serovar

Choleraesuis] SEQ ID n~2109

Contig9 from dbj |BAB05769.l| (AP001514) BH2050-unknown SEQ ID n° 6394 PL-4032.1 597396 to m 473 conserved protein [Bacillus halodurans]

597872 SEQ ID n~3182 pir| |H75377 conserved hypothetical protein -

Contig9 from

Deinococcus radiodurans (strain Ri) SEQ ID n° 6395 PL-4031.2 597882 to m 333 gb|AAF11145.l|AE002002_3 (AE002002) conserved

598637 hypothetical protein [Deinococcus radiodurans] #N/A pir| |H71196 hypothetical protein PH1846 -

Contig9 from

Pyrococcus horikoshii dbj |BAA30967.l| SEQ ID n° 6396 PL-4431.1 598645 to 38% (AP000007) 273aa long hypothetical protein

599397

[Pyrococcus horikoshii] #N/A

Contig9 from emb|CAB88835.l| (AL353832) putative ABC- SEQ ID n° 6397 PL-4430.1 599387 to 43% transport protein, ATP-binding component.

600151 [Streptomyces coelicolor A3 (2)] #N/A Contig9 from SEQ ID n° 6398 PL-3213.2 600153 to m No Hits found

601799 SEQ ID n~2466

TABLEAU II

sp|P00 29|TRPA_jSALTY TRYPTOPHAN SYNTHASE ALPHA

CHAIN pir| |TSEBAT tryptophan synthase (EC

4.2.1.20) alpha chain - Salmonella typhimurium pdb|lQOQ|A Chain A, Crystal

Structure Of Wild-Type Tryptophan Synthase

Complexed With Indole Glycerol Phosphate pdb|lCW2|A Chain A, Crystal Structure Of The

Complex Of Bacterial Tryptophan Synthase With The Transition State Analogue

Inhibitor 4- (2-

Hydroxyphenylsulfinyl) -Butylphosphonic Acid

Contig9 from pdb|lC8V|A Chain A, Crystal Structure Of The SEQ ID n° 6399 PL-1462.2 602637 to 81%

Complex Of Bacterial Tryptophan

603443

Synthase With The Transition State Analogue

Inhibitor 4- (2- Hydroxyphenylthio)-

Butylphosphonic Acid pdb|lC29|A Chain A,

Crystal Structure Of The Complex Of Bacterial

Tryptophan Synthase With The

Transition State Analogue Inhibitor 4-

(2- Hydroxyphenylthio) -1-Butenylρhosphonic Acid pdb | 1C9D | Chain A, Crystal Structure Of The

Complex Of Bacterial Tryptophan Synthase With The Transition State Analogue Inhibitor 4- (2- Hydroxy-4- SEQ ID n~550

Contig9 from pdb|lQOP|B Chain B, Crystal Structure Of Wild-

SEQ ID n° 6400 PL-1461.1 603443 to m 913 Type Tryptophan Synthase Complexed

604633 With Indole Propanol Phosphate SEQ ID n~549

TABLEAU II

sp|P00910|TRPC_SALTY TRYPTOPHAN BIOSYNTHESIS

PROTEIN TRPCF [INCLUDES: INDOLE-3 -GLYCEROL

PHOSPHATE SYNTHASE (IGPS) ; N-(5'-

PHOSPHO-RIBOSYL) ANTHRANILATE ISOMERASE (PRAI) ] pi || GWEBT indole-3 -glycerol-phosphate synthase

Contig9 from

(EC 4.1.1.48) / SEQ ID n° 6401 PL-1460.1 604710 to 76% phosphoribosylanthranilate isomerase (EC

606074

5.3.1.24) - Salmonella typhimurium gb|AAA27237.l| (M30286) N- (5 ' -phosphoribosyl) - anthranilic acid isomerase/indole-3- glycerol phosphate synthetase

[Salmonella typhimurium] SEQ ID n~548 sp|P00904|TRPG_ECOLI ANTHRANILATE SYNTHASE

COMPONENT II [INCLUDES: GLUTAMINE

AMIDOTRANSFERASE; ANTHRANILATE

PHOSPHORIBOSYLTRANSFERASE ] pir| |NNEC2 anthranilate synthase (EC 4.1.3.27)

Contig9 from component II - Escherichia coli dbj |BAA14798. l| SEQ ID n° 6402 PL-1459.1 606077 to 81%

(D90764) Anthranilate synthase (EC 4.1.3.27)

607093 component II [Escherichia coli] gb|AAC74345.l| (AE000224) anthranilate synthase component II, glutamine amidotransferase and phosphoribosylanthranilate transferase [Escherichia coli K12] SEQ ID n~346 sp|P0090θ|TRPG_SERMA ANTHRANILATE SYNTHASE

Contig9 from

COMPONENT II (GLUTAMINE AMIDO-TRANSFERASE) SEQ ID n° 6403 PL-3803.1 607089 to 81% gb|AAA57309.l| (J01792) trpG [Serratia

607667 marcescens] SEQ ID n-2981

TABLEAU II

sp|P00895|TRPE_ECOLI ANTHRANILATE SYNTHASE

COMPONENT I pir| |NNEC1 anthranilate synthase

(EC 4.1.3.27) component I - Escherichia coli dbj |BAA14799.l| (D90764) Anthranilate synthase

Contig9 from component I (EC 4.1.3.27). SEQ ID n° 6404 PL-1458.1 607667 to m 77%

[Escherichia coli] dbj |BAA14814. l| (D90765)

609241

Anthranilate synthase component I (EC 4.1.3.27) .

[Escherichia coli] gb|AAC74346. l| (AE000224) anthranilate synthase component I [Escherichia coli K12] SEQ ID n~545

Contig9 from

SEQ ID n° 6405 PL-7035.1 609306 to No Hits found

609425 #N/A

Contig9 from emb|CAA72201.l] (Y11391) exochitinase [Glossina

SEQ ID n° 6406 PL-1457.1 610098 to 563 morsitans S-endosymbiont]

611732 SEQ ID n~344

Contig9 from gb] AC38628.l| (AF047028) insecticidal toxin

SEQ ID n° 6407 PL-1456.2 611829 to 283 complex protein TccA [Photorhabdus

615350 luminescens] SEQ ID n~S43

Contig9 from gb|AAC38629.l| (AF047028) insecticidal toxin

SEQ ID n° 6408 PL-1455.1 615343 to 36% complex protein TccB [Photorhabdus

619431 luminescens] SEQ ID n~5 2

Contig9 from emb|CAA72201.l| (Y11391) exochitinase [Glossina

SEQ ID n° 6409 PL-1454.1 619559 to 483 morsitans S-endosymbiont]

621427 SEQ ID n~S41

Contig9 from

SEQ ID n° 6410 PL-1453.1 621737 to 72% sp|θ54453 |TRPH_SALTY TRPH PROTEIN

622489 SEQ ID n~540

Contig9 from sp|P45847|YCI0_EC0LI 23.2 KDA PROTEIN IN TRPL-

SEQ ID n° 6411 PL-1452.1 622517 to 903 BTUR INTERGENIC REGION

623137 SEQ ID n~339

C

SEQ ID n° 6412 PL-1451.1

TABLEAU II

Contig9 from pir] |E69931 hypothetical protein yozl - Bacillus SEQ ID n° 6413 PL-4427.1 625201 to m 40% subtilis emb]CAB13779.l| (Z99114) yozl

625437 [Bacillus subtilis] #N/A pir||C83339 hypothetical protein PA2462

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 6414 PL-1450.1 625457 to m 34% (strain PAOl) gb| AAG05850.1 ] AE004673_10

630520 (AE004673) hypothetical protein [ seudomonas aeruginosa] SEQ ID n~537

Contig9 from gb|AAG56546.l|AE005380_5 (AE005380) orf, SEQ ID n° 6415 PL-1449.1 631039 to p 81% hypothetical protein [Escherichia coli 0157 :H7]

631971 SEQ ID n~535 sp|P13040|BTUR_ECOLI COB(I)ALAMIN

ADENOSYLTRANSFERASE (CORRINOID

ADENOSYLTRANSFERASE) pir]|A64875 cob(I)alamin adenosyltransferase (EC 2.5.1.17) - Escherichia coli gb|AAA23530.l| (M21528) btuR protein

[Escherichia coli) dbj ]BAA14807.1 | (D90764)

Contig9 from

Cob(I)alamin adenosyltransferase (EC 2.5.1.17) SEQ ID n° 6416 PL-3802.1 632008 to m 813

(Corrinoid adenosyltransferase) .

632604

[Escherichia coli] dbj |BAA14822.l| (D90765)

Cob(I)alamin adenosyltransferase (EC 2.5.1.17)

(Corrinoid adenosyltransferase) .

[Escherichia coli] gb|AAC74352.l| (AE000225) cob(I)alamin adenolsyltransferase [Escherichia coli K12] SEQ ID n~2980 sp|P31808|YCIK_ECOLI HYPOTHETICAL OXIDOREDUCTASE

IN BTUR-SOHB INTERGENIC REGION pir| |B64875 probable dehydrogenase (EC 1.1.1.-) yciK -

Contig9 from

Escherichia coli dbj |BAA14808.I] (D90764) SEQ ID n° 6417 PL-1448.1 632604 to 73%

Internalin B [Escherichia coli] dbj |BAA14823. l|

633368

(D90765) Internalin B [Escherichia coli] gb|AAC74353.l| (AE000225) putative oxidoreductase [Escherichia coli K12] SEQ ID n~534

TABLEAU II

sp ] PO048 | CAT3_ECOLI CHLORAMPHENICOL

ACETYLTRANSFERASE III pir | | XXEBCF chloramphenicol O-acetyltransferase (EC

2.3.1.28) III - Shigella flexneri

Contig9 from plasmid R387 pdb|3CLA| Type III SEQ ID n° 6418 PL-1447.1 633698 to p 60%

Chloramphenicol Acetyltransferase (CATIII)

634336

(E.C. .3.1.28) Complex With

Chloramphenicol emb | CAA30695.l| (X07848) chloramphenicol acetyltransferase (AA 1-213)

[Ξnterobacteriaceae] SEQ ID n~333

Contig9 from SEQ ID n° 6419 PL-7243.1 634386 to p No Hits found

634502 #N/A Contig9 from SEQ ID n° 6420 PL-4421.1 634665 to No Hits found

635045 #N/A ref |NP_044235. l| TnpA [Enterobacter aerogenes]

Contig9 from pir| |T08494 probable transposase - Enterobacter SEQ ID n° 6421 PL-1446.1 635130 to 843 aerogenes plasmid R751 gb|AAB03489.l| (U60777)

636134 transposase [Plasmid R751] gb| AAC64438.1 |

(U67194) TnpA [Enterobacter aerogenes] SEQ ID n~S32

Contig9 from gb|AAC98740.l| (AF052750) transposase SEQ ID n° 6422 PL-3801.1 636676 to m 68% [Pseudomonas putida]

637056 SEQ ID n~2979 Contig9 from gb|AAC98740.l| (AF052750) transposase SEQ ID n° 6423 PL-3800.1 637137 to 59% [Pseudomonas putida]

637685 SEQ ID n~2978 Contig9 from SEQ ID n° 6424 PL-4420.1 638086 to No Hits found

638244 #N/A Contig9 from SEQ ID n° 6425 PL-1445.1 638278 to No Hits found

638883 SEQ ID n~331 Contig9 from SEQ ID n° 6426 PL-3799.1 639261 to p No Hits found

639788 SEQ ID n~2975

TABLEAU II

Contig9 from emb| CAC19493.l| (AJ296651) nematicidal protein 2 SEQ ID n° 6427 PL-1444.1 639863 to 413 [Xenorhabdus bovienii]

645190 SEQ ID n~S30 Contig9 from SEQ ID n° 6428 PL-4415.1 645263 to No Hits found

645445 #N/A Contig9 from SEQ ID n° 6429 PL-4414.1 645728 to m No Hits found

646084 #N/A Contig9 from SEQ ID n° 6430 PL-4412.1 646517 to No Hits found

646744 #N/A Contig9 from gb|AAG56543.l|AE005380_2 (AE005380) putative SEQ ID n° 6431 PL-1443.1 647159 to 77% protease [Escherichia coli 0157 :H7]

648205 SEQ ID n~329 Contig9 from SEQ ID n° 6432 PL-4411.1 648496 to No Hits found

648675 #N/A pir| |B75474 probable chloride peroxidase -

Contig9 from

Deinococcus radiodurans (strain RI) SEQ ID n° 6433 PL-1442.1 648734 to 333 gb]AAF10370.l|AE001934_l (AE001934) chloride

649564 peroxidase, putative [Deinococcus radiodurans] SEQ ID n~528

Contig9 from gb|AAG56541.l|AE005379_9 (AE005379) DNA SEQ ID n° 6434 PL-1441.1 650326 to 90% topoisomerase type I, oméga protein [Escherichia

652926 coli 0157 :H7] SEQ ID n~327

TABLEAU II

sp|P06613|CYSB_ECOLI CYS REGULON TRANSCRIPTIONAL

ACTIVATOR pir| |RGΞCCB regulatory protein cysB -

Escherichia coli gb|AAA23642.1 j (M15041) cysB regulatory protein [Escherichia coli] gb|AAA23643.l| (M34332) cysteine regulatory

Contig9 from protein (cysB) [Escherichia coli]

SEQ ID n° 6435 PL-1440.1 653231 to 833 dbj |BAAl4827.l| (D90765) Regulatory protein CysB

654205 [Escherichia coli] gb| AAC74357.1 | (AE000225) positive transcriptional regulator for cysteine regulon [Escherichia coli K12] gb|AAG56540.l|AE005379_8 (AE005379) positive transcriptional regulator for cysteine regulon

[Escherichia coli 0157:H7] SEQ ID n~326

Contig9 from

SEQ ID n° 6436 PL-1439.1 654381 to m No Hits found

655208 SEQ ID n~324

Contig9 from pir| |G64875 aconitate hydratase (EC 4.2.1.3) -

SEQ ID n° 6437 PL-1438.1 655461 to p 84% Escherichia coli gb| AAC74358.1 | (AE000225)

658136 aconitate hydrase 1 [Escherichia coli K12] SEQ ID n~S23 sp]P 5523]GCH2_ECOLI GTP CYCLOHYDROLASE II pir| |A40654 GTP cyclohydrolase II (EC 3.5.4.25)

Escherichia coli emb| CAA48075. l| (X67876) GTP cyclohydrolase II [Escherichia coli]

Contig9 from dbj |BAA14831.1| (D90766) GTP cyclohydrolase II

SEQ ID n° 6438 PL-1437.1 658286 to m 81%

(EC 3-5.4.25) [Escherichia coli] gb | AAC74359.1 | 658894

(AE000226) GTP cyclohydrolase II [Escherichia coli K12] gb|AAG56536.l|AE005379_4 (AE005379)

GTP cyclohydrolase II (EC 3.5.4.25) [Escherichia coli 0157:H7] SEQ ID n~322

Contig9 from SEQ ID n° 6439 PL-4408.1 659096 to No Hits found

659239 #N/A

TABLEAU II

sp|P77614|YCIS_ECOLI HYPOTHETICAL 11.4 KDA

PROTEIN IN PGPB-PYRF INTERGENIC REGION pir| |B64876 probable membrane protein ycis -

Contig9 from

Escherichia coli dbj |BAA14833.l| (D90766) SEQ ID n° 6440 PL-4407.1 659400 to 73%

ORF__ID:θ255#4; similar to [SwissProt Accession

659711

Number P44129] [Escherichia coli] gb|AAC74361.l| (AE000226) orf, hypothetical protein [Escherichia coli K12] #N/A sp|P45576|YCIM_ECOLI HYPOTHETICAL 44.5 KD

PROTEIN IN PGPB-PYRF INTERGENIC REGION

PRECURSOR pir| |C64876 yciM protein precursor -

Escherichia coli dbj |BAA14834.l| (D90766)

Contig9 from

ORF_iD:o255#5; similar to [SwissProt Accession SEQ ID n° 6441 PL-1436.2 659718 to p 843

Number P45576] [Escherichia coli]

660887 gb|AAC74362.l| (AE000226) putative heat shock protein [Escherichia coli K12] gb|AAG56533.l|AE005379_l (AE005379) putative heat shock protein [Escherichia coli 0157 :H7] SEQ ID n~321

Contig9 from gb|AAG56532.l|AE005378_ll (AE005378) orotidine- SEQ ID n° 6442 PL-1435.1 660932 to p 803 5 ' -phosphate decarboxylase [Escherichia coli

661678 0157:H7] SEQ ID n~3 0 pir| |Q3ECPF translation initiation factor SUI

Contig9 from

[si ilarity] - Escherichia coli gb]AAC74364. l| SEQ ID n° 6443 PL-4406.1 661668 to p 843

(AE000226) orf, hypothetical protein

661994

[Escherichia coli K12] #N/A gb|AAC25764.l| (AF072709) putative

Contig9 from transcriptional regulator [Streptomyces SEQ ID n° 6444 PL-1434.1 662384 to p 403 lividans] emb|CAC14337.l| (AL445945) putative

662989 regulatory protein [Streptomyces coelicolor] SEQ ID n~319 pir] |C82971 conserved hypothetical protein

Contig9 from PA5395 [imported] - Pseudomonas SEQ ID n° 6445 PL-3797.1 663014 to p 773 aeruginosa (strain PA01)

663493 gb]AAG08780.l]AE004952_2 (AE004952) conserved hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2974

TABLEAU II

Contig9 from gb]AAG31049.l|AF264948_ll (AF264948) SEQ ID n° 6446 PL-1433.1 663593 to m 37% hypothetical protein [Erwinia amylovora]

664873 SEQ ID n~S18 Contig9 from SEQ ID n^» 6447 PL-4402.1 664870 to m No Hits found

665232 #N/A pir] ]F81046 hypothetical protein NMB1759 -

Contig9 from Neisseria meningitidis (group B SEQ ID n° 6448 PL-1432.1 665500 to 58% Strain MD58) gb|AAF42100.l| (AE002525)

666849 conserved hypothetical protein [Neisseria meningitidis MC58] SEQ ID n~S17

Contig9 from dbj |BAA34597.l] (AB020025) dermσnecrotizing SEQ ID n° 6449 PL-1431.1 666937 to 143 toxin [Bordetella bronchiseptica]

671847 SEQ ID n-S16 Contig9 from dbj |BAB06239.l| (AP001515) transposase related SEQ ID n° 6450 PL-1430.1 672123 to 21% protein (20) [Bacillus halodurans]

673148 SEQ ID n~S15 Contig9 from emb|CAA7233 .3 | (Y11597) reverse SEQ ID n° 6451 PL-4400.1 673294 to 44% transeriptase/maturase [Sinorhizobium meliloti]

673674 #N/A Contig9 from SEQ ID n° 6452 PL-4397.1

Contig9 from SEQ ID n° 6453 PL-4396.1 674251 to m No Hits found

674478 #N/A pir| |E82175 conserved hypothetical protein

Contig9 from VC1631 [imported] - Vibrio cholerae SEQ ID n° 6454 PL-1429.1 674447 to 453 (group Ol strain N16961) gb| AAF9478 .1 |

675514 (AEO04241) conserved hypothetical protem

[Vibrio cholerae] SEQ ID n~313

TABLEAU II

ref |NP_073225. l| ransposase of IS630 [Salmonella enterica serovar Choleraesuis] db |BAA01531.1 |

Contig9 from

(D10689) M5 protein [Salmonella choleraesuis] SEQ ID n° 6455 PL-1428.2 675602 to p 72% dbj |BAB20556.l| (AB040415) ransposase of IS630

676615

[Salmonella enterica serovar

Choleraesuis] #N/A

Contig9 from SEQ ID n° 6456 PL-1427.1 676958 to m No Hits found

678025 SEQ ID n~311 Contig9 from dbj [BAB07432.1] (AP001519) glycosyltransferase SEQ ID n° 6457 PL-1426.1 678902 to p 40% [Bacillus halodurans]

679681 SEQ ID n~510 Contig9 from SEQ ID n° 6458 PL-1425.2 679762 to p No Hits found

680946 SEQ ID n~309 Contig9 from SEQ ID n° 6459 PL-1424.1 680948 to p No Hits found

681820 SEQ ID n~308 pir| |E82182 enterobactin synthetase component F- related protein VC1579 [imported] -

Contig9 from

Vibrio cholerae (group 01 strain N16961) SEQ ID n° 6460 PL-1423.1 681805 to p 37% gb|AAF94733.l| (AE004235) enterobactin

683190 synthetase component F-related protein

[Vibrio cholerae] SEQ ID n~S07

Contig9 from SEQ ID n° 6461 PL-4393.1 683169 to p No Hits found

683390 #N/A Contig9 from SEQ ID n° 6462 PL-1422.1 683691 to p No Hits found

684761 SEQ ID n~S06 Contig9 from SEQ ID n° 6463 PL-1421.1 684748 to p No Hits found

685518 SEQ ID n~305

TABLEAU II

pιr| |D75096 aspartate aminotransferase (aspb-

Contig9 from likel) PAB0774 - Pyrococcus abyssi

SEQ ID n° 6464 PL-1420.1 685515 to 483 (strain Orsay) emb|CAB50073.l| (AJ248286)

686600 aspartate aminotransferase (aspB-likel)

[Pyrococcus abyssi] SEQ ID n~S04 sp|0 6358|NDK_MΞTTH NUCLEOSIDE DIPHOSPHATE

KINASE (NDK) (NDP KINASE) pir| |D69132 nucleoside-diphosphate kinase (EC 2.7.4.6) -

Contig9 from

Methanobacterium thermoautotrophicum

SEQ ID n° 6465 PL-3795.1 686594 to 503

(strain Delta H) gb] AAB84764.1 | (AE000812)

687064 nucleoside diphosphate kinase

[Methanothermobacter thermautotrophicus] SEQ ID n-2972

Sp|P51565|TNP9_ECOLI TRANSPOSASE FOR TRANSPOSON

Contig9 from TN1721 pir| |JQ1477 transposase - Escherichia SEQ ID n° 6466 PL-4392.1 687256 to m 703 coli transposon Tnl721 emb|CAA43641.l| (X61367)

687447 transposase [Escherichia coli] emb | CAA90481.1 |

(Z50120) transposase [synthetic construct] #N/A ref |NP_054620.l| unknown [Yersinia pestis] ref |NP_047619.l| Yop targeted effector [Yersinia pestis] pir| |T43601 yop targeted effector yopT •

Contig9 from Yersinia pestis plasmid pCDl gb| AAC62582. l|

SEQ ID n° 6467 PL-1419.1 687609 to m 563 (AF053946) unknown [Yersinia pestis]

688580 gb|AAC69833.l| (AF074612) Yop targeted effector

[Yersinia pestis] emb | CAB54897.l| (AL117189) putative cytotoxic effector protein [Yersinia pestis] SEQ ID n~S02

Contig9 from emb] CAA36717.1] (X52478) dermonecrotic toxin (AA

SEQ ID n° 6468 PL-1418.1 688857 to m 363 1-1285) [Pasteurella multocida]

690563 SEQ ID n~S01

Contig9 from emb|CAB77354. l| (AL160331) hypothetical protein

SEQ ID n° 6469 PL-1417.1 690778 to m 233 SCD8A.33c (fragment) [Streptomyces

691680 coelicolor A3 (2)] SEQ ID n~300

Contig9 from emb|CAB77353.l| (AL160331) putative AAA family

SEQ ID n° 6470 PL-1416.2 691705 to m 223 ATPase [streptomyces coelicolor

693786 A3 (2)] SEQ ID n~499

TABLEAU II

Contig9 from

SEQ ID n° 6471 PL-1415.2 693796 to m No Hits found

695226 SEQ ID n~498

Contig9 from

SEQ ID n° 6472 PL-1414.1 695269 to m No Hits found

698304 SEQ ID n~?97

Contig9 from

SEQ ID n° 6473 PL-1413.1 698330 to m No Hits found

702382 SEQ ID n~496

Contig9 from

SEQ ID n° 6474 PL-3794.1 702466 to m No Hits found

702882 SEQ ID n~2971

Contig9 from emb|CAB77339.l| (AL160331) hypothetical protein

SEQ ID n° 6475 PL-4389.1 702879 to m 433 SCD8A.18C [Streptomyces coelicolor

703301 A3 (2)] #N/A

Contig9 from emb|CAB77340.l| (AL160331) hypothetical protein

SEQ ID n° 6476 PL-1412.1 703314 to m 39% SCD8A.19C [Streptomyces coelicolor

704918 A3 (2)] SEQ ID n~495

Contig9 from

SEQ ID n° 6477 PL-1411.1 704915 to m No Hits found

705598 SEQ ID n~494

Contig9 from

SEQ ID n° 6478 PL-4386.1 705585 to m No Hits found

705764 #N/A

Contig9 from

SEQ ID n° 6479 PL-3793.1 705761 to m No Hits found

706219 SEQ ID n~2970

Contig9 from emb|CAB77347. l| (AL160331) hypothetical protein

SEQ ID n° 6480 PL-1410.1 706238 to m 263 SCD8A.26C [Streptomyces coelicolor

707404 A3 (2)] SEQ ID n~493

Contig9 from emb | cAB77347 . l | (AL160331) hypothetical protein

SEQ ID n° 6481 PL-1409.1 707459 to m 243 SCD8A.26c [Streptomyces coelicolor

708751 A3 (2 ) ] SEQ ID n~491

Contig9 from emb|CAB77347.l] (AL160331) hypothetical protein

SEQ ID n° 6482 PL-1408.1 708809 to m 303 SCD8A.26c [Streptomyces coelicolor

709885 A3 (2)] SEQ ID n~490

TABLEAU II

Contig9 from emb| CAB77342.l| (AL160331) hypothetical protein

SEQ ID n° 6483 PL-3792.1 709959 to 353 SCD8A.21c [Streptomyces coelicolor

710408 A3 (2)] SEQ ID n~2969 sp | P30850 ] RNB_ECOLI EXORIBONUCLEASE II

(RIBONUCLEASE II) (RNASE II) pir] |A64877 exoribonuclease II (EC 3.1.13.1) - Escherichia coli dbj |BAA14840.ι| (D90766) Exoribonuclease

Contig9 from II (EC 3.1.13.1) (Ribonuclease II) (RNase

SEQ ID n° 6484 PL-1407.1 710937 to m 803 II). [Escherichia coli] dbj |BAA14848.l|

712880 (D90767) Exoribonuclease II (EC 3.1.13.1)

(Ribonuclease II) (RNase il) .

[Escherichia coli] gb|AAC74368.1 | (AE000226)

RNase II, mRNA dégradation [Escherichia coli

K12] SEQ ID n~489 sp|P206 5[END3_ECOLI ENDONUCLEASE III (DNA-

(APURINIC OR APYRIMIDINIC SITE) LYASE) pir| |A32412 DNA- (apurinic or apyrimidinic site) lyase (EC 4.2.99.18) endonuclease III

[validated] - Escherichia coli pdb|2ABK|

Refinement Of The Native Structure Of

Endonuclease lii To A Resolution Of

1.85 Angstrom gb|AAA24227.l| (J02857)

Contig9 from endonuclease III [Escherichia coli]

SEQ ID n° 6485 PL-1406.1 713020 to m 883 dbj |BAA15387.1 | (D90806) Deoxyribonuclease

713658 (pyrimidine dimer) (EC 3.1.25.1)

[Escherichia coli] dbj |BAA15394.1 | (D90807)

Deoxyribonuclease (pyrimidine dimer) (EC

3.1.25.1) [Escherichia coli] dbj |BAA15 17.1 | (D90808) Deoxyribonuclease

(pyrimidine dimer) (EC 3.1.25.1)

[Escherichia coli] gb| AAC74705.1 | (AE000258) endonuclease III; spécifie for apurinic and/or apyrimidinic sites [Escherichia coli K12] SEQ ID n~488

Contig9 from gb|AAG56621.l]AE005386_12 (AE005386) orf,

SEQ ID n° 6486 PL-1405.1 713660 to m 783 hypothetical protein [Escherichia coli 0157 :H7]

714358 SEQ ID n-«87

TABLEAU II

Contig9 from gb|AAG56620.l|AE005386_ll (AE005386) orf, SEQ ID n^α 6487 PL-1404.1 714355 to m 783 hypothetical protein [Escherichia coli 0157 :H7]

714984 SEQ ID n~486 sp|P76182|YDG0_EC0LI HYPOTHETICAL 38.1 KD

PROTEIN IN ADD-NTH INTERGENIC REGION

Contig9 from pir| |H64919 probable membrane protein ydgO SEQ ID n° 6488 PL-1403.1 714994 to m 76% precursor - Escherichia coli gb| AC74702.1 |

716073

(AE000258) orf, hypothetical protein

[Escherichia coli K12] SEQ ID n~«85 pir] |G64919 probable iron-sulfur protein bl629 -

Escherichia coli dbj |BAA15384.l| (D90806)

Glucose repression mediator protein.

Contig9 from [Escherichia coli] dbj |BAA15391. l| (D90807) SEQ ID n° 6489 PL-1402.1 716086 to m 63? Glucose repression mediator protein.

718644 [Escherichia coli] dbj |BAA15414.1] (D90808)

Glucose repression mediator protein. [Escherichia coli] gb | AAC74701.l| (AE000258) putative membrane protein [Escherichia coli K12] SEQ ID n~484 sp|P77223|YDGM_ECOLI PUTATIVE FERREDO IN- IKE

PROTEIN IN ADD-NTH INTERGENIC REGION pir| |F64919 probable iron-sulfur protein bl628 precursor - Escherichia coli db |BAA15383.l|

Contig9 from

(D90806) Ferredoxin II. [Escherichia coli]

SEQ ID n° 6490 PL-1401.1 718637 to 743 dbj |BAA15390.l| (D90807) Ferredoxin II .

719269

[Escherichia coli] dbj ]BAA15413.l| (D90808)

Ferredoxin II. [Escherichia coli] gb|AAC74700.l| (AE000258) orf , hypothetical protem [Escherichia coli K12] SEQ ID n~483

Contig9 from pir| |E64919 probable membrane protein bl627 - SEQ ID n° 6491 PL-3789.1 719269 to m 873 Escherichia coli gb|AAC74699. l| (AE000258) orf,

719850 hypothetical protein [Escherichia coli K12] SEQ ID n~2967 Contig9 from gb|AAG56615.l|AΞ005386_6 (AE005386) orf, SEQ ID n° 6492 PL-4385.1 719977 to m 56% hypothetical protein [Escherichia coli 0157 :H7]

720417 #N/A

TABLEAU II

Contig9 from gb|AAG56613.1 |AE005386_4 (AE005386) orf, SEQ ID n° 6493 PL-1400.1 720601 to 77% hypothetical protein [Escherichia coli 0157 :H7]

721638 SEQ ID n~482 Contig9 from gb|AAG57528.l|AE005471_5 (AE005471) putative SEQ ID n° 6494 PL-1399.1 721847 to 79% cytochrome oxidase [Escherichia coli 0157 :H7]

722818 SEQ ID n~479 Contig9 from SEQ ID n° 6495 PL-4383.1 723254 to No Hits found

723535 #N/A pir| |A82602 conserved plasmid protein XF2066

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 6496 PL-4381.1 724052 to m 93% (strain 9a5c) gb|AAF84865.l| AE004023_1

724351 (AE004023) conserved plasmid protein [Xylella fastidiosa] #N/A pir| |C82602 hypothetical protein XF2068

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 6497 PL-3787.1 724369 to m 64% (strain 9a5c) gb| AAF84867.l|AE004023_3

724833 (AE004023) hypothetical protein [Xylella fastidiosa] SEQ ID n~2965

Contig9 from SEQ ID n° 6498 PL-4379.1 724963 to m No Hits found

725088 #N/A pir| |B70537 hypothetical protein Rvlll3 -

Contig9 from

Mycobacterium tuberculosis (strain SEQ ID n° 6499 PL-4378.1 725172 to 36%

H37RV) emb|CAB09045.l] (Z95585) hypothetical

725375 protein Rvlll3 [Mycobacterium tuberculosis] #N/A pir| |C70537 hypothetical protein Rvlll4 -

Contig9 from

Mycobacterium tuberculosis (strain SEQ ID n° 6500 PL-4377.1 725375 to 45%

H37RV) emb|CAB09046.l| (Z95585) hypothetical

725752 protein Rvlll4 [Mycobacterium tuberculosis] #N/A

Contig9 from SEQ ID n° 6501 PL-4376.1 725868 to p No Hits found

726020 #N/A Contig9 from gb]AAC82515.l| (AF027767) PemI [Morganella SEQ ID n° 6502 PL-4375.1 726379 to 96% morganii]

726636 #N/A

TABLEAU II

ref |NP_052994.l| plasmid stable inheritance protein [Plasmid RIO0] sp | P13976 | PEMK_ECOLI

PEMK PROTEIN pir| | 164784 hypothetical protein 3

Contig9 from

- Escherichia coli plas ids emb|CAA29585. l| SEQ ID n° 6503 PL-3786.1 726581 to 72%

(X06240) ORF 3 (AA 1-133) [Ξnterobacteriaceae]

726970 gb|AAA26070.l| (M26840) 0RF3 [Escherichia coli] dbj |BAA78898.l| (AP000342) plasmid stable inheritance protein [Plasmid R100] SEQ ID n~2964

Contig9 from gb|AAC8252l.l| (AF027768) MucA [Serratia

SEQ ID n° 6504 PL-4374.1 727060 to 463 marcescens]

727287 #N/A

Contig9 from

SEQ ID n° 6505 PL-4371.1 727514 to No Hits found

727762 #N/A sp| P22333 |ADD_ECOLI ADENOSINE DEAMINASE

(ADENOSINE AMINOHYDROLASE) pir| |A64919 adenosine deaminase (EC 3.5.4.4) - Escherichia coli dbj |BAA15374.1 | (D90805) Adenosine deaminase (EC 3.5.4.4) (Adenosine

Contig9 from aminohydrolase) . [Escherichia coli] SEQ ID n° 6506 PL-1398.1 727971 to 693 dbj |BAA15381. l| (D90806) Adenosine deaminase (EC

728972 3.5.4.4) (Adenosine aminohydrolase).

[Escherichia coli] dbj |BAA15411. l| (D90808)

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) . [Escherichia coli] gb|AAC74695.l| (AE000258) adenosine deaminase

[Escherichia coli K12] SEQ ID n~478

TABLEAU II

Sp|P77804|YDGA_ECOLI HYPOTHETICAL 54.7 KDA

PROTEIN IM MANA-GUSC INTERGENIC REGION pir] |H64917 probable membrane protein ydgA -

Escherichia coli dbj |BAA15362.l| (D90804)

Contig9 from ORF_ID:o312#14; similar to [SwissProt Accession SEQ ID n° 6507 PL-1397.1 729050 to m 543 Number P32128] [Escherichia coli]

730597 dbj |BAA15366.1 | (D90805) 0RF_ID:θ312#1 ; similar to [SwissProt Accession Number

P32128] [Escherichia coli] gb | AAC74686.l|

(AE000257) orf, hypothetical protein

[Escherichia coli K12] SEQ ID n~477

Contig9 from gb|AAG56600.l|AE005385_l (AE005385) mannose-6-

SEQ ID n° 6508 PL-1396.1 730737 to 73% phosphate isomerase [Escherichia coli 0157 :H7]

731909 SEQ ID n~476

Contig9 from gb|AAG56598.l]AE005334_8 (AE005384) fumarase C=

SEQ ID n° 6509 PL-1395.1 732214 to 893 fumarate hydratase Class II; isozyme

733608 [Escherichia coli 0157 :H7] SEQ ID n~475

Contig9 from gb|AAG22119.l| (AY008264) hypothetical protein

SEQ ID n° 6510 PL-3785.1 733676 to m 643 [Yersinia enterocolitica]

734146 SEQ ID n~2963

Contig9 from gb|AAG22120.l| (AY008264) hypothetical protein

SEQ ID n° 6511 PL-3784.1 734143 to 66% [Yersinia enterocolitica]

734589 SEQ ID n-2962

Contig9 from gb|AAF68950.l| (AF231032) DNA réplication

SEQ ID n° 6512 PL-1394.1 734662 to m 723 terminus site-binding protein [Yersinia

735588 pestis] SEQ ID n~474

Contig9 from

SEQ ID n° 6513 PL-3783.1 736403 to No Hits found

736870 SEQ ID n~2961

Contig9 from

SEQ ID n° 6514 PL-4369.1 736874 to m No Hits found

737092 #N/A

TABLEAU II

pir| |D83174 probable acetylpolyaminé aminohydrolase PA3774 [imported] -

Contig9 from

Pseudomonas aeruginosa (strain PAOl) SEQ ID n° 6515 PL-1393.1 737363 to p 80% gb|AAG07161.l|AE004796__6 (AE004796) probable

738475 acetylpolyamine aminohydrolase [Pseudomonas aeruginosa] SEQ ID n~473

Contig9 from pir] | W0070 chitin binding protein 21 precursor SEQ ID n° 6516 PL-1392.1 738696 to m 54% Serratia marcescens dbj |BAA31569.l| (AB015998)

739295 CBP21 precursor [Serratia marcescens] SEQ ID n~472 pir| |H69795 conserved hypothetical protein yesF

Contig9 from Bacillus subtilis emb|^"CAB12507.1 j (Z99107) SEQ ID n° 6517 PL-1391.1 739488 to p 54% alternate gène name : yeeM, yfxB-similar to

740321 hypothetical proteins [Bacillus subtilis] SEQ ID n~471 sp|P06202|θPPA_SALTY PERIPLASMIC OLIGOPEPTIDE- BINDING PROTEIN PRECURSOR pir| | QREBOA

Contig9 from oligopeptide-binding protein precursor - SEQ ID n° 6518 PL-1390.2 740404 to m 67% Salmonella typhimurium emb|CAA29039.l| (X05491)

742014 Opp A (AA1-542) [Salmonella typhimurium] emb|CAA27785.l| (X04194) precursor polypeptide [Salmonella typhimurium] SEQ ID n~470 pir] |T35441 aldéhyde dehydrogenase -

Contig9 from Streptomyces coelicolor emb|CAA19895.ι| SEQ ID n° 6519 PL-1389.2 742645 to 72% (AL031035) aldéhyde dehydrogenase [Streptomyces

744075 coelicolor A3 (2) ] SEQ ID n~468

Contig9 from gb|AAB97824.l| (AF013216) unknown [Myxococcus SEQ ID n° 6520 PL-1388.1 744235 to 19% xanthus]

744864 SEQ ID n~467

TABLEAU II

sp | P50457 | GOAG_ECOLI 4 -AMINOBUTYRATE

AMINOTRANSFERASE (GAMMA-AMINO-N-BUTYRATE

TRANSAMINASE) (GABA TRANSAMINASE)

(GLUTAMATE : SUCCINIC SEMIALDEHYDE

TRANSAMINASE) (GABA AMINOTRANSFERASE)

(GABA-AT) pir| |A64879 4-aminobutyrate transaminase (EC 2.6.1.19) goaG - Escherichia

Contig9 from coli gb|AAC45301.l| (U38543) GABA-

SEQ ID n° 6521 PL-1387.1 745159 to 733 aminotransferase [Escherichia coli]

746436 dbj |BAA14871.l| (D90768) 4-aminobutyrate aminotransferase (EC 2.6.1.19) (Gamma- amino-N-butyrate transaminase) (GABA transaminase) (Glutamate: succinic semialdehyde transaminase) (GABA aminotransferase) .

[Escherichia coli] gb|AAC74384. l|

(AE000228) 4-aminobutyrate aminotransferase

[Escherichia coli K12] SEQ ID n~466 sp|P4262l|YHAH_ECOLI HYPOTHETICAL 14.3 KD

PROTEIN IN EXUR-TDCC INTERGENIC REGION pir| |D65099 hypothetical 14.3 kD protein in exuR

Contig9 from tdcC intergenic région - Escherichia SEQ ID n° 6522 PL-4366.1 746475 to 563 coli (strain K-12) gb| AAC76138. l| (AE000392)

746843 putative cytochrome [Escherichia coli K12] gb|AAG58236.l|AE005540_l (AE005540) putative cytochrome [Escherichia coli θl57:H7] #N/A pir| |A83578 conserved hypothetical protein

Contig9 from PA053 [imported] - Pseudomonas SEQ ID n° 6523 PL-1386.1 746901 to 373 aeruginosa (strain PAOl)

748442 gb|AAG03923.1 |AE004490_3 (AE004490) conserved hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~465

Contig9 from gb|AAG10092.l|U79570_l (U79570) glucose SEQ ID n° 6524 PL-1385.1 748641 to 493 dehydrogenase [Bacillus licheniformis]

749411 SEQ ID n~464 Contig9 from SEQ ID n° 6525 PL-1384.2 749565 to m No Hits found

750302 SEQ ID n~463

TABLEAU II

pir| |E83504 probable oxidoreductase PA1137

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 6526 PL-1383.2 750525 to 64% (strain PAOl) gb |AAG04526.1 |AE004543_10

751541 (AEO04543) probable oxidoreductase [Pseudomonas aeruginosa] SEQ ID n~462 pir| |H82234 probable glutamate decarboxylase

Contig9 from VC1149 [imported] - Vibrio cholerae SEQ ID n° 6527 PL-1382.1 751982 to 343 (group 01 strain N16961) gb|AAF94308.1 |

753907 (AE004195) glutamate decarboxylase, putative

[Vibrio cholerae] SEQ ID n~461 sp|P18199]TYRP_ECOLI TYROSINE-SPECIFIC TRANSPORT

PROTEIN (TYROSINE PERMEASE) pir| | GRΞCY tyrosine' spécifie transport protein - Escherichia coli

Contig9 from dbj |BAA15730.l| (D90832) Tyrosine-specific SEQ ID n° 6528 PL-1381.1 753952 to 833 transport protein (Tyrosine permease) .

755160

[Escherichia coli] gb|AAC74977.l| (AE000284) tyrosine-specific transport system [Escherichia coli K12] SEQ ID n~460

Contig9 from ref |NP_052313.l| ORF C8 [Ralstonia solanacearum] SEQ ID n° 6529 PL-3781.1 755274 to 723 dbj |BAA32221.l| (AB015669) ORF C8 [Ralstonia

755708 solanacearum] SEQ ID n~2960 ref |NP_073098.l| conserved hypothetical protein

[Mycoplasma genitalium] sp | P47666 | Y427_MYCGE

Contig9 from HYPOTHETICAL PROTEIN MG427 pirj |B64247 SEQ ID n° 6530 PL-1380.1 755965 to p 273 conserved hypothetical protein MG427 -

756474 Mycoplasma genitalium gb [AAC72448.1 | (U39725) conserved hypothetical protein [Mycoplasma genitalium] SEQ ID n~459

Contig9 from SEQ ID n° 6531 PL-4364.1 756635 to m No Hits found

756949 #N/A pir| |T44585 acyl-CoA oxidase homolog [imported]

Contig9 from Streptomyces fradiae gb |AAD40800. l|AF145049_1 SEQ ID n° 6532 PL-1379.1 757474 to 353 (AF145049) acyl-CoA oxidase [Streptomyces

759237 fradiae] SEQ ID n~457

TABLEAU II

Contig9 from gb|AAC38629.l| (AF047028) insecticidal toxin SEQ ID n° 6533 PL- 1378.1 759499 to 573 complex protein TccB [Photorhabdus

760281 luminescens] SEQ ID n~456 Contig9 from gb|AAC38629.l| (AF047028) insecticidal toxin SEQ ID n° 6534 PL-1377.1 760146 to m 483 complex protein TccB [Photorhabdus

761231 luminescens] SEQ ID n~455 Contig9 from gb|AAC38629.l| (AF047028) insecticidal toxin SEQ ID n° 6535 PL-4363.1 761153 to 52% complex protein TccB [Photorhabdus

761314 luminescens] #N/A Contig9 from pir| |B47048 plasmid stabilization protein ParE - SEQ ID n° 6536 PL-4361.1 761354 to 573 plasmid RK2

761590 #N/A pir| |B82608 plasmid stabilization protein XF2032

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 6537 PL-4360.1 761503 to 723 (strain 9a5c) gb|AAF84834. l|AΞ004021_11

761622 (AΞ004021) plasmid stabilization protein

[Xylella fastidiosa] #N/A

Sp|P2 995[PAD4_ECOLI PARD PROTEIN pir||A37141 parD protein - Escherichia coli plasmid RP4 pir| |A47048 plasmid stabilization protein ParD - plasmid RK2 pir| |S70153 parD protein -

Xanthomonas sp pir| |S32830 parD protein -

Contig9 from

Xanthomonas sp. plasmid RP1 transposon Tn5053 SEQ ID n° 6538 PL-4359.1 761659 to m 793 gb|AAA91498.l| (L03728) putative [Escherichia

761913 coli] gb|AAA92774.l| (L05507) parD gène product

[Plasmid RK2] gb|AAA26418.1 | (M59825) parD

[Plasmid RP4] gb |AAA98334. l| (L40585) putative

[Xanthomonas sp. W17] gb|AAB67690.1 | (U75325)

ParD [Cloning vector pJB32l] #N/A

Contig9 from pir| |T28654 transposase - Pseudomonas putida SEQ ID n° 6539 PL-4358.1 762764 to 403 plasmid pPGHl emb | CAA70598.1 | (Y09450)

762964 transposase [Pseudomonas putida] #N/A Contig9 from SEQ ID n° 6540 PL-1376.1 762971 to No Hits found

763627 #N/A

TABLEAU II

Contig9 from emb|CAA07406.l| (AJ006986) transmembrane protein

SEQ ID n° 6541 PL-1375.1 763770 to 443 [Streptococcus pneumoniae]

764681 SEQ ID n~454

Contig9 from

SEQ ID n° 6542 PL-1374.1 764998 to No Hits found

766005 SEQ ID n~453 pir| |E70047 conserved hypothetical protein yvrK •

Bacillus subtilis emb| CAB15314.1 | (Z99120)

Contig9 from similar to hypothetical proteins [Bacillus SEQ ID n° 6543 PL-1373.1 766541 to 523 subtilis] emb|CAB15329.l| (Z99121) similar to

767707 hypothetical proteins [Bacillus subtilis] emb|CAA11727.l| (AJ223978) YvrK protein

[Bacillus subtilis] SEQ ID n-452 pir| |T17443 salicyl-AMP ligase (EC 6.2.1.-) ybtE

[similarity] - Yersinia pestis gb| AAA93464. l|

(U50364) YbtE [Yersinia pestis] gb | AAC69591.1 |

(AF091251) salicyl-AMP ligase YbtE [Yersinia

Contig9 from pestis] emb|CAA 1394.l| (AL031866) ORF 71, SEQ ID n° 6544 PL-1372.1 767900 to 35% len=525 aa, ybtE, 100% identity in 525 aa

770833 overlap, with YPU50364_2 Yersinia pestis yersiniabactin 2 , 3-dihydoxybenzoate-

AMP ligase (ybtE) (525 aa) , Fasta scores: opt: 3451, E{): 0 SEQ ID n~451

Contig9 from pir| |T17442 ybtT protein - Yersinia pestis

SEQ ID n° 6545 PL-1371.1 770833 to 56% gb|AAC69590.l| (AF091251) YbtT [Yersinia pestis]

771609 SEQ ID n~450

Contig9 from pir| |T30343 irp3 protein - Yersinia

SEQ ID n° 6546 PL-1370.1 771636 to 563 enterocolitica emb|CAA73128.l| (Y12527) Irp3

772733 protein [Yersinia enterocolitica] SEQ ID n~449

TABLEAU II

pir| |T17440 probable polyketide synthase -

Yersinia pestis gb| AC69588.l| (AF091251) Ybt peptide/polyketide synthetase HMWP1 [Yersinia pestis] emb|CAA21391.l| (AL031866) ORF68,

Contig9 from len≈3163 aa, irpl, function≈synthesis of

SEQ ID n° 6547 PL-1369.1 772730 to m 233 siderophore yersiniabactin, product≈HMWPl 784456 protein, 97.9% identity in 3163 aa overlap to YEIRPOP_l Y. enterocolitica irpl, Fasta scores: opt: 2088, E() : 0 [Yersinia pestis] SEQ ID n~447 pir] |T17439 peptide synthetase homolog irp2 - Yersinia pestis gb|AAC69587.1 ] (AF091251) Ybt peptide synthetase HMWP2 [Yersinia pestis] emb|CAA21390.l| (AL031866) ORF67, len=2041 aa,

Contig9 from irp2, function≈synthesis of

SEQ ID n° 6548 PL-1368.1 784456 to m 61% siderophore yersiniabactin, product=HMWP2

790605 protein 98.6% identity in 2035 aa overlap to HMP2_YEREN. also highly similar to ANGR_VIBAN, (1048 aa) , 44.4% identity in 917 aa overlap, Fasta scores: > SEQ ID n~446 pir| |T47045 hypothetical protein ybtP [imported]

- Yersinia pestis emb | CAA21388.1 | (AL031866)

Contig9 from ORF 65, len=600 aa, yersiniabactin uptake, ABC SEQ ID n° 6549 PL-1366.1 790648 to m 473 Transporter, similar to many, eg. MTCY02B10_12 M.

792450 tuberculosis (859 aa) , 35.7% identity in 577 aa overlap Fasta scores: opt: 1064,

E():0 [Yersinia pestis] SEQ ID n~445 pir] |T47045 hypothetical protein ybtP [imported]

- Yersinia pestis emb| CAA21388.1 | (AL031866)

Contig9 from ORF 65, len=600 aa, yersiniabactin uptake, ABC

SEQ ID n° 6550 PL-1365.1 792395 to 49% Transporter, similar to many, eg. MTCY02B10__12 M.

794113 tuberculosis (859 aa) , 35.7% identity in 577 aa overlap Fasta scores: opt: 1064,

Ξ() -.0 [Yersinia pestis] SEQ ID n~444

TABLEAU II

pir| |T47043 hypothetical protein ybtX [imported]

- Yersinia pestis emb | CAA21386.1 | (AL031866)

Contig9 from 0RF63,len=462 aa, putative transmembrane SEQ ID n° 6551 PL-1364.1 794187 to m 51% protein, si ilarity to E. coli

795395 ΞCAMPG3_1 E.coli ampG3 gène, 27.1% identity in 376 aa overlap, Fasta scores: opt:

311, E() : l.le-12 [Yersinia pestis] SEQ ID n~443

Contig9 from emb|CAA86212.l| (Z38065) FyuA precursor SEQ ID n° 6552 PL-1363.1 795428 to m 493 [Escherichia coli]

797434 SEQ ID n~442 pir] |S74448 regulatory protein pcrR -

Contig9 from

Synechocystis sp. (strain PCC 6803) SEQ ID n° 6553 PL-1362.1 797731 to 243 dbj |BAA16600.1 | (D90899) regulatory protein PcrR

798702

[Synechocystis sp.] SEQ ID n~441

Contig9 from dbj |BAB06239.1| (AP001515) transposase related SEQ ID n° 6554 PL-1361.1 798990 to 213 protein (20) [Bacillus halodurans]

800015 SEQ ID n~440 Contig9 from gb]AAA81002.1] (U11258) extracellular lipase SEQ ID n° 6555 PL-1360.1 800033 to m 793 [Serratia marcescens]

801886 SEQ ID n~439 pir| |B47055 DNA-invertase - Erwinia amylovora transposon Tn5393 gb| AAC37003.1 | (M77502) putative resolvase [Pseudomonas syringae]

Contig9 from gb]AAA98411.2 | (M96392) resolvase [Erwinia SEQ ID n° 6556 PL-4344.1 802645 to 39% amylovora] gb| AAA27439.2 | (M95402) resolvase

803025

[Transposon Tn5393] gb| AG39040.l| AF262622_2

(AF262622) putative resolvase [Aeromonas salmonicida subsp. salmonicida] #N/A sp|P44190 |YE19_HAEIN HYPOTHETICAL PROTEIN HI1419 pir| |B64029 hypothetical protein HI1419 -

Contig9 from

Haemophilus influenzae (strain Rd SEQ ID n° 6557 PL-3780.1 803079 to 473

KW20) gb]AAC23069.l| (U32821) H. influenzae

803381 predicted coding région HI1419 [Haemophilus influenzae Rd] SEQ ID n~2959

TABLEAU II

sp|P44191|YE20_HAEIN HYPOTHETICAL PROTEIN HI1420 pir| |C64029 hypothetical protein HI1420 -

Contig9 from

Haemophilus influenzae (strain Rd SEQ ID n° 6558 PL-4341.1 803378 to p 78%

KW20) gb|AAC23070.l| (U32821) H. influenzae

803656 predicted coding région HI1420

[Haemophilus influenzae Rd] #N/A

Contig9 from gb|AAC80183.l| (U73041) plasmid stability-like SEQ ID n° 6559 PL-4339.1 803869 to p 46% protein [Acidithiobacillus

804003 ferrooxidans] #N/A pir| |A82603 hypothetical protein XF2074

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 6560 PL-4337.1 804094 to m 70% (strain 9a5c) gb|AAF84873.1 | AE004023_9

804384 (AE004023) hypothetical protein [ ylella fastidiosa] #N/A pir| |B82603 hypothetical protein XF2075

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 6561 PL-4336.1 804372 to m 63% (strain 9a5c) gb|AAF84874.l|AE004023_10

804644 (AE004023) hypothetical protein [Xylella fastidiosa] #N/A

Contig9 from gb|AAC80183.l[ (U73041) plasmid stability-like SEQ ID n° 6562 PL-4335.1 804739 to 433 protein [Acidithiobacillus

804873 ferrooxidans] #N/A Contig9 from ref |NP_037718.l| tail fiber [Bacteriophage HK97] SEQ ID n° 6563 PL-1359.1 805289 to 343 gb]AAF31111.l| (AF069529) tail fiber

806164 [Bacteriophage HK97] SEQ ID n-437 Contig9 from SEQ ID n° 6564 PL-4333.1 806409 to m No Hits found

806663 #N/A Contig9 from gb|AAB92577.l| (AF037441) putative 19.5 kDa SEQ ID n° 6565 PL-1358.1 807388 to p 523 protein [Edwardsiella ictaluri]

807939 SEQ ID n~436 Contig9 from gb|AAB92576.l[ (AF037441) putative 54.5 kDa SEQ ID n° 6566 PL-1357.1 807947 to p 733 protein [Edwardsiella ictaluri]

809428 SEQ ID n~435

TABLEAU II

Contig9 from gb|AAB92575.l| (AF037441) putative 17.8 kDa SEQ ID n° 6567 PL-3779.1 809485 to 533 protein [Edwardsiella ictaluri]

809979 SEQ ID n~2957 Contig9 from gb|AAB92574.1 (AF037441) putative 18.8 kDa SEQ ID n° 6568 PL-4332.1 810031 to 453 protein [Edwardsiella ictaluri]

810474 #N/A pir| |C83349 hypothetical protein PA2369

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 6569 PL-1356.1 810479 to p 463 (strain PAOl) gb|AAG05757. l|AΞ004663_3

812290 (AE004663) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~434 pir| (D83349 hypothetical protein PA2370

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 6570 PL-1355.1 812281 to p 443 (strain PAOl) gb|AAG05758.11AE004663__4

813291 (AE004663) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~433 pir] |G83310 conserved hypothetical protein

Contig9 from PA2685 [imported] - Pseudomonas SEQ ID n° 6571 PL-1354.1 813316 to p 503 aeruginosa (strain PAOl)

815322 gb|AAG06073.l|AE004696_7 (AE004696) conserved hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~432 pir] |H83542 hypothetical protein PA0824

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 6572 PL-4330.1 815950 to p 433 (strain PAOl) gb| AAG04213. l| AΞ004517_8

816252 (AE004517) hypothetical protein [Pseudomonas aeruginosa] #N/A pir| |D83350 hypothetical protein PA2360

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 6573 PL-1352.1 816266 to p 443 (strain PAOl) gb| AAG05748.l| E004662_3

817369 (AE004662) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~430 pir] |E82499 hypothetical protein VCA0114

Contig9 from

[imported] - Vibrio cholerae (group SEQ ID n° 6574 PL-1350.1 818043 to p 403

Ol strain N16961) gb| AAF96028. l| (AE004353)

819440 hypothetical protein [Vibrio cholerae] SEQ ID n~429

TABLEAU II

pir| |F82499 hypothetical protein VCA0115

Contig9 from

[imported] - Vibrio cholerae (group SEQ ID n° 6575 PL-1349.1 819440 to 293

01 strain N16961) gb | AAF96029.1 | (AE004353)

820060 hypothetical protein [Vibrio cholerae] SEQ ID n~427 pir] |H83437 hypothetical protein PA1669

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 6576 PL-1348.1 820076 to 123 (strain PAOl) gb |AAG05058.l| AE004594_10

823585 (AEO 04594) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~426 pir| |G83635 probable ClpA/B-type chaperone

Contig9 from PAO090 [imported] - Pseudomonas SEQ ID n° 6577 PL-1347.1 823578 to 61% aeruginosa (strain PAOl)

826160 gb|AAG03480.l|AE004447_13 (AE004447) probable

ClpA/B-type chaperone [Pseudomonas aeruginosa] SEQ ID n~425

Contig9 from SEQ ID n° 6578 PL-1346.1 826210 to No Hits found

827469 SEQ ID n~424 pir| |B83182 probable two-component response regulator PA3714 [imported] -

Contig9 from Pseudomonas aeruginosa (strain PAOl) SEQ ID n° 6579 PL-1345.1 827500 to 663 gb|AAG07101.l|AE004790_6 (AE004790) probable two-

828126 component response regulator [Pseudomonas aeruginosa] SEQ ID n~423

Sp]P4033θ|BVGS_BORPA VIRULENCE SENSOR PROTEIN BVGS PRECURSOR pir||si7946 virulence sensor

Contig9 from protein bvgS precursor - Bordetella SEQ ID n° 6580 PL-1344.1 828298 to 44% parapertussis emb|CAA37124.l| (X52948) bvgS

831741 product, put. sensor protein [Bordetella parapertussis] SEQ ID n~422

Contig9 from SEQ ID n° 6581 PL-4326.1 831886 to No Hits found

832086 #N/A

TABLEAU II

pir||C81839 probable transposase for IS1655

NMA1481 [imported] - Neisseria meningitidis (group B strain MD58, group A

Contig9 from

Strain Z2491) emb|CAB84714.l| (AL162756) SEQ ID n° 6582 PL-1343.1 832229 to 57% putative transposase for IS1655 [Neisseria

833197 meningitidis Z2491] emb| CAB84719.l|

(AL162756) putative transposase for IS1655

[Neisseria meningitidis Z2491] SEQ ID n~421

Contig9 from ref |NP_040375.l| entry exclusion protein 2

SEQ ID n° 6583 PL-3777.1 833179 to 38% (exc2) [Plasmid ColEl] gb|AAB59140. l| (J01566)

833637 entry exclusion protein 2 (exc2) [Plasmid ColEl] SEQ ID n~ 955

Contig9 from gb|AAD17306.l| (AF121418) putative Phd protein

SEQ ID n° 6584 PL-4325.1 833693 to 47% [Francisella tularensis subsp.

833947 novicida] #N/A

Contig9 from gb|AAG54353.l|AE005182_2 (AE005182) putative

SEQ ID n° 6585 PL-4324.1 834218 to m 513 toxin of gyrase inhibiting toxin-antitoxin

834523 system [Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG54352.l|AE005182_l (AE005182) putative

SEQ ID n° 6586 PL-4323.1 834525 to m 53% antitoxin σf gyrase inhibiting toxin-

834764 antitoxin system [Escherichia coli 0157 :H7] #N/A

Contig9 from

SEQ ID n° 6587 PL-3776.1 834852 to m No Hits found

835223 SEQ ID n~2954

Contig9 from

SEQ ID n° 6588 PL-1342.2 835518 to m No Hits found

836090 SEQ ID n~420

Contig9 from emb|CAA28394.l| (X04691) xylose isomerase (AA 1-

SEQ ID n° 6589 PL-1341.1 836510 to m 444) [Escherichia coli]

837829 SEQ ID n~419

TABLEAU II

sp|P3739θ|XYLR_ΞCOLI XYLOSE OPERON REGULATORY

PROTEIN pir||S47790 xylose operon regulatory protein - Escherichia coli gb |AAB18546.1 |

Contig9 from (U00039) xylR [Escherichia coli] gb |AAC76593.1 | SEQ ID n° 6590 PL-1340.1 838140 to 813 (AE000434) putative regulator of xyl operon

839321 [Escherichia coli K12] gb|AAG58718.l|AE005583_10 (AE005583) putative regulator of xyl operon [Escherichia coli

0157 :H7] SEQ ID n~418 pir| |H82185 6-phosρho-beta-glucosidase VC1558

Contig9 from [imported] - Vibrio cholerae (group

SEQ ID n° 6591 PL-1339.1 839362 to 80%

01 strain N16961) gb| AAF94712.1 | (AE004233) 6-

840804 phospho-beta-glucosidase [Vibrio cholerae] SEQ ID n~416 pir| |T18583 glucosylceramidase (EC 3.2.1.45) precursor - Caenorhabditis elegans emb|CAA20283.l| (AL031254) predicted using

Genefinder-contains similarity to Pfam domain: PF02055 (O-Glycosyl hydrolase family

30), Score=571.9, E-value=l.3e-168,

N=l~cDNA EST yk386f5.3 cornes from

Contig9 from this gene-cDNA EST yk206c8.5 cornes from this

SEQ ID n° 6592 PL-1338.2 840843 to m 493 gene-cDNA EST yk448c6.5 co> emb| CAB02924.1 ] 842156

(Z81058) predicted using Genefinder-contains similarity to Pfam domain: PF02055 (O-

Glycosyl hydrolase family 30) ,

Score=571.9, E-value=1.3e-168, N=l~cDNA EST yk386f5.3 cornes from this gene-cDNA

EST yk206c8.5 cornes from this gene-cDNA EST yk448c6.5 come> SEQ ID n~415

Contig9 from emb|CAB77656.l| (AJ390519) hypothetical protein

SEQ ID n° 6593 PL-1337.2 842346 to 603 [Candida albicans]

843224 SEQ ID n~414

Contig9 from ref |NP_052450.l| yacA [Plasmid ColIb-P9]

SEQ ID n° 6594 PL-4321.1 843528 to 463 dbj |BAA75089.l] (AB021078) yacA [Plasmid Collb-

843806 P9] #N/A

TABLEAU II

Contig9 from ref |NP_052451.l| yacB [Plasmid Collb-P9] SEQ ID n° 6595 PL-4319.1 843803 to 523 dbj |BAA75090.l| (AB021078) yacB [Plasmid Collb-

844093 P9] #N/A pir||G70799 hypothetical protein Rv3750c -

Contig9 from Mycobacterium tuberculosis (strain SEQ ID n° 6596 PL-3775.1 844312 to 373 H37RV) emb|CAA18072.l| (AL022121) hypothetical

844773 protein Rv3750c [Mycobacterium tuberculosis] SEQ ID n~2953

Contig9 from SEQ ID n° 6597 PL-1336.1 845415 to p No Hits found

846374 SEQ ID n~413 Contig9 from gb|AAC38151.l| (AF034088) lipase [Pseudomonas SEQ ID n° 6598 PL-1335.1 846711 to m 52% sp. Bll-1]

847631 SEQ ID n~412 Contig9 from ref |NP_053106.l| orf44 [Escherichia coli] SEQ ID n° 6599 PL-4317.1 847961 to 813 dbj |BAA84879.1 | (AB024946) orf44 [Escherichia

Contig9 from sp|Q60228|RELX_ECOLI HYPOTHETICAL RELE-LIKE SEQ ID n° 6600 PL-4316.1 848209 to 853 PROTEIN gb]AAB61759.l| (M26308) ORF6 [Plasmid

848496 IncF] #N/A Contig9 from dbj | BAB20938 .1 | (AB053207) endo-beta-N- SEQ ID n° 6601 PL-1334.1 848652 to 223 acetylglucosaminidase [Flavobacterium sp .

849563 SK1022] SEQ ID n-411 ref |NP_071207. l| molybdopterin oxidoreductase, molybdopterin binding subunit

[Archaeoglobus fulgidus] pir] |H69547

Contig9 from molybdopterin oxidoreductase, molybdopterin SEQ ID n° 6602 PL-1333.2 849767 to p 303 binding subunit homolog

853213 Archaeoglobus fulgidus gb [ AB9127 .1 |

(AEOOlill) molybdopterin oxidoreductase, molybdopterin binding subunit

[Archaeoglobus fulgidus] SEQ ID n~410

Cσntig9 from SEQ ID n° 6603 PL-1332.1 853879 to No Hits found

854991 SEQ ID n~409

TABLEAU II

pir||F83628 beta-alanine- -pyruvate transaminase

PAO132 [imported] - Pseudomonas

Contigg from aeruginosa (strain PAOl) SEQ ID n° 6604 PL-1331.1 855248 to 85% gb|AAG03522.l|AE004451_3 (AE004451) beta-alanine-

856579

-pyruvate transaminase [Pseudomonas aeruginosa] SEQ ID n~β08

Contig9 from gb|AAF33136.l|AF196567_12 (AF196567) PdtorfL SEQ ID n° 6605 PL-1330.1 856700 to m 43? [Pseudomonas stutzeri]

859111 SEQ ID n~S07 pdb|lB65|A Chain A, Structure Of L-

Aminopeptidase D-Ala-EsteraseAMIDASE FROM

Ochrobactrum Anthropi, A Prototype For The

Serine Aminopeptidases, Reveals A New

Variant Among The Ntn Hydrolase Fold pdb]lB65|B Chain B, Structure Of L-

A inopeptidase D-Ala-EsteraseAMIDASE FROM

Ochrobactrum Anthropi, A Prototype For The

Serine Aminopeptidases, Reveals A New

Variant Among The Ntn Hydrolase Fold

Contig9 from pdb[lB65|c Chain C, structure Of L- SEQ ID n° 6606 PL-1329.1 859477 to 62% Aminopeptidase D-Ala-EsteraseAMIDASE FROM

860670 Ochrobactrum Anthropi, A Prototype For The

Serine Aminopeptidases, Reveals A New

Variant Among The Ntn Hydrolase Fold pdb|lB65|D Chain D, Structure Of L-

Aminopeptidase D-Ala-EsteraseAMIDASE FROM

Ochrobactrum Anthropi, A Prototype For The

Serine Aminopeptidases, Reveals A New

Variant Among The Ntn Hydrolase Fold pdb[lB65|E Chain Ξ, Structure Of L-

Aminopeptidase D-Ala-EsteraseAMIDASE FROM

Ochrobactrum Anthropi, A Prototype For The SEQ ID n~405

Contig9 from SEQ ID n° 6607 PL-4315.1 861082 to m No Hits found

861366 #N/A

TABLEAU II

Contig9 from SEQ ID n° 6608 PL-4314.1 861586 to m No Hits found

861882 #N/A Contig9 from

Sp|P40819|YHHV__SALTY HYPOTHETICAL PROTEIN IN SEQ ID n° 6609 PL-4313.1 862765 to m 35% LIVF 5' REGION

862944 #N/A Contig9 from gb|AAC26596.l| (U83995) putative protease SEQ ID n° 6610 PL-1328.1 863081 to 59% [Porphyromonas gingivalis]

863965 SEQ ID n-404 ref |NP_043483.l| orf14 [Bacteriophage HPl] sp|P51716|YO!4_BPHPl HYPOTHETICAL 1 .9 KD

Contig9 from

PROTEIN IN REP-HOL INTERGENIC REGION (0RF14) SEQ ID n° 6611 PL-4312.1 864107 to m 42% pir| |S69520 hypothetical protein 14 - phage HPl

864397 gb|AAB09l99.l| (U24159) orf14 [Bacteriophage

HPl] #N/A ref ]NP_047626.l| unknown [Yersinia pestis] pir| |T42908 hypothetical protein Y0075 -

Contig9 from

Yersinia pestis plasmid pCDl gb | AAC69816.1 | SEQ ID n° 6612 PL-4311.1 864497 to m 793

(AF074612) unknown [Yersinia pestis]

8S4772 emb|CAB54885.l| (AL117189) hypothetical protein

YPCD1.08C [Yersinia pestis] #N/A ref |NP_052428.1 | unknown [Yersinia

Contig9 from enterocolitica] gb|AAC33681.l| (AF056093) SEQ ID n° 6613 PL-4310.1 864783 to m 81% unknown [Yersinia enterocolitica]

865025 gb|AADl685l.l| (AF102990) unknown [Yersinia enterocolitica] #N/A pir||S75133 hypothetical protein slr2101 -

Contig9 from

Synechocystis sp. (strain PCC 6803) SEQ ID n° 6614 PL-3774.1 865147 to 473 dbj |BAA17995.l| (D90910) hypothetical protein

865587

[Synechocystis sp . ] SEQ ID n~2952 sp|Q10612|YC84_MYCTU HYPOTHETICAL 18.2 KDA

Contig9 from PROTEIN RV1284 pir] |H70771 hypothetical protein SEQ ID n° 6615 PL-1327.1 866058 to 48% Rvl 84 - Mycobacterium tuberculosis (strain

866639 H37RV) emb|CAA97750.l| (Z73419) hypothetical protein Rvl284 [Mycobacterium tuberculosis] SEQ ID n~403

TABLEAU II

pir| |D70035 permease homolog yveA - Bacillus

Contig9 from subtilis emb |CAB08050.l| (Z94043) hypothetical SEQ ID n° 6616 PL-1326.1 866734 to m 73% protein [Bacillus subtilis] emb|CAB15452.l|

868335

(Z99121) similar to permease [Bacillus subtilis] SEQ ID n~402 pir||F83368 probable aldéhyde dehydrogenase

Contig9 from PA2217 [imported] - Pseudomonas SEQ ID n° 6617 PL-1325.1 868396 to m 703 aeruginosa (strain PAOl)

869979 gb|AAG05605.l|AE004648_4 (AΞ004648) probable aldéhyde dehydrogenase [Pseudomonas aeruginosa] SEQ ID n-401 pir| |D83488 probable dihydrodipicolinate synthetase PA1254 [imported] -

Contig9 from

Pseudomonas aeruginosa (strain PAOl) SEQ ID n° 6618 PL-1324.1 870021 to m 743 gb|AAG04643.1 | AE004555_3 (AE004555) probable

870941 dihydrodipicolinate synthetase [Pseudomonas aeruginosa] SEQ ID n~400 pir||C83489 probable transcription regulator

PA1261 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 6619 PL-1323.1 871170 to m 56% gb|AAG04650.l|AE004555_10 (AE004555) probable

871994 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~399 pir| |G83487 hypothetical protein PA1268

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 6620 PL-1322.1 872248 to 74% (Strain PAOl) gb|AAG04657.l]AE004556_7

873210 (AEO 04556) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~398 pir| |F83487 hypothetical protein PA1267

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 6621 PL-1321.1 873207 to 633 (strain PAOl) gb | AAG04656.l| AE004556_6

874334 (AE004556) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n-397 ref |NP_053432.l| Hypothetical gène

Contig9 from

[Agrobacterium tumefaciens] dbj JBAA87817. l| SEQ ID n° 6622 PL-4309.1 874331 to p 38%

(AB016260) Hypothetical gène [Agrobacterium

874585 tumefaciens] #N/A

TABLEAU II

pir| |E83487 probable oxidoreductase PA1266

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 6623 PL-1320.1 874588 to 5? (strain PAOl) gb | AAG04655.1 | AE004556_5

875880 (AE004556) probable oxidoreductase [Pseudomonas aeruginosa] SEQ ID n~396

Contig9 from emb|CAB90977.l| (AL355832) hypothetical protein

SEQ ID n° 6624 PL-1319.1 876020 to 613 SCE22.10 [Streptomyces coelicolor

876997 A3 (2)] SEQ ID n~394

Contig9 from gb[AAD43990.l|U59485_17 (U59485) AttM

SEQ ID n° 6625 PL-1318.1 877157 to 793

[Agrobacterium tumefaciens]

877927 SEQ ID n~393

Contig9 from pir||S76629 hypothetical protein - Synechocystis

SEQ ID n° 6626 PL-1317.1 878040 to 3c sp. (strain PCC 6803) dbj | BAA10573.1 | (D64004)

878987 hypothetical protein [Synechocystis sp.] SEQ ID n~392 pir| ]T36402 probable monooxygenase -

Contig9 from

Streptomyces coelicolor emb|CAB53314.1 | SEQ ID n° 6627 PL-1316.1 879629 to 39%

(AL109974) putative monooxygenase [Streptomyces

880864 coelicolor A3 (2)] SEQ ID n~391

Contig9 from emb|CAA72201.l| (Y11391) exochitinase [Glossina

SEQ ID n° 6628 PL-1315.1 881099 to m 613 morsitans S-endosymbiont]

882802 SEQ ID n~390

Contig9 from emb|CACH387.l| (AL445063) probable histidine

SEQ ID n° 6629 PL-1314.1 883203 to 47% ammonia-lyase [Thermoplasma

884801 acidophilum] SEQ ID n~389

Contig9 from gb|AAG56223.l|AE005351_2 (AE005351) putative

SEQ ID n° 6630 PL-1313.1 885026 to 773 oxidoreductase [Escherichia coli 0157 :H7]

885775 SEQ ID n~388 sp|P7617θ|YNFB_ECOLI HYPOTHETICAL 12.9 KD PROTEIN IN RSPA-SPEG INTERGENIC REGION

Contig9 from

PRECURSOR pir] |A64914 hypothetical protein SEQ ID n° 6631 PL-4306.1 885907 to 563 bl583 - Escherichia coli gb | AAC74655.1 |

886269

(AΞ000254) orf, hypothetical protein

[Escherichia coli K12] #N/A

Contig9 from gb|AAG56573.l(AE005382_7 (AE005382) orf, SEQ ID n° 6632 PL-4305.1 886285 to 60% hypothetical protein [Escherichia coli 0157 :H7]

886548 #N/A

TABLEAU II

pir| |T29511 hypothetical protein C41G11.1 -

Contig9 from

Caenorhabditis elegans gb | AAA85743. l| (U46669)

SEQ ID n° 6633 PL-1312.2 886863 to 143 coded for by C. elegans cDNA ykl8f9.5

888260

[Caenorhabditis elegans] SEQ ID n~387

Contig9 from SEQ ID n° 6634 PL-4304.1 888378 to m No Hits found

888533 #N/A Contig? from SEQ ID n° 6635 PL-4303.1 889047 to No Hits found

889439 #N/A Contig9 from sp|P7720l|BID2_ECOLI PUTATIVE DETHIOBIOTIN SEQ ID n° 6636 PL- 1311.1 889893 to m 593 SYNTHETASE (DETHIOBIOTIN SYNTHASE) (DTB

890600 SYNTHETASE) (DTBS) SEQ ID n-386 Contig9 from gb|AAG56581.l|AE005383_3 (AΞ005383) putative SEQ ID n° 6637 PL-1310.1 890765 to m 743 NAGC-like transcriptional regulator

891976 [Escherichia coli 0157 :H7] SEQ ID n~3 S5 sp | P77559 | YNFL_ECOLI HYPOTHETICAL

TRANSCRIPTIONAL REGULATOR IN MLC-ASR INTERGENIC

REGION pir| |Ξ64915 probable transcription regulator ynfL - Escherichia coli

Contig9 from dbj |BAA15319.1 | (D90801) als operon regulatory SEQ ID n° 6638 PL-1309.1 892108 to m 67% protein. [Escherichia coli] dbj | BAA15329.ι|

893022

(D90802) als operon regulatory protein.

[Escherichia coli] gb | AAC74667.1 | (AE000255) putative transcriptional regulator LYSR-type

[Escherichia coli K12] SEQ ID n~383 sp|P4353l]YNFM_ECOLI HYPOTHETICAL 45.3 KD

PROTEIN IN MLC-ASR INTERGENIC REGION pir||F649l5 membrane protein ynfM - Escherichia

Contig9 from coli dbj |BAA15330.l| (D90802) Bicyclomycin SEQ ID n° 6639 PL- 1308.1 893149 to 753 résistance protein (Sulfonamide résistance

894423 protein). [Escherichia coli] gb|AAC74668.l|

(AEO00255) putative transport protein

[Escherichia coli K12] SEQ ID n~382

TABLEAU II

Contig9 from

SEQ ID n° 6640 PL-1307.1 894579 to No Hits found

895595 SEQ ID n~381

Contig9 from emb|CAC19493.l| (AJ296651) nematicidal protein 2

SEQ ID n° 6641 PL-1306.2 896502 to 42% [Xenorhabdus bovienii]

901379 SEQ ID n-380

Contig9 from

SEQ ID n° 6642 PL-1304.2 901523 to m No Hits found

902545 SEQ ID n~379

Contig9 from

SEQ ID n° 6643 PL-3772.1 902557 to No Hits found

903117 SEQ ID n~2950 sp| 067611 |ACP_AQUAE ACYL CARRIER PROTEIN (ACP)

Contig9 from pir| |A70448 acyl carrier protein - Aquifex SEQ ID n° 6644 PL-4299.1 903170 to m 473 aeolicus gb | AAC07567.1 [ (AE000752) acyl carrier

903415 protein [Aquifex aeolicus] #N/A

Contig9 from SEQ ID n° 6645 PL-1303.2 903428 to No Hits found

904204 SEQ ID n~378 pir] |B70448 3-oxoacyl- [acyl-carrier-protein]

Contig9 from synthase (EC 2.3.1.41) II - Aquifex SEQ ID n° 6646 PL-1302.1 904210 to 543 aeolicus gb| AAC07574.1 [ (AE000752) 3-oxoacyl-

905475 [acyl-carrier-protein] synthase II [Aquifex aeolicus] SEQ ID n~377

Contig9 from gb|AAD28497.l|AF061787_4 (AF061787) McJD SEQ ID n° 6647 PL-1301.1 906606 to m 433 [Escherichia coli]

907985 SEQ ID n~376 pir| |T09914 protein-arginine N-methyltransferase (EC 2.1.1.23) - Arabidopsis thaliana

Contig9 from emb|CAB45311.l| (AL079344) arginine SEQ ID n° 6648 PL-1300.1 907976 to 38% methyltransferase (paml) [Arabidopsis thaliana]

908854 emb|CAB79709.l| (AL161575) arginine methyltransferase (paml) [Arabidopsis thaliana] SEQ ID n~375

Contig9 from SEQ ID n° 6649 PL-1299.1 908854 to No Hits found

909726 SEQ ID n~372

TABLEAU II

Contig9 from SEQ ID n° 6650 PL-4297.1 910114 to No Hits found

910248 #N/A sp|P06202|θPPA_SALTY PERIPLASMIC OLIGOPEPTIDE- BINDING PROTEIN PRECURSOR pir| | QREBOA

Contig9 from oligopeptide-binding protein precursor - SEQ ID n° 6651 PL-1298.1 910275 to 66% Salmonella typhimurium emb|CAA29039.l] (X05491)

911885 Opp A (AA1-542) [Salmonella typhimurium] emb|CAA27785.l| (X04194) precursor polypeptide [Salmonella typhimurium] SEQ ID n~371

Contig9 from SEQ ID n° 6652 PL-4296.1 912103 to No Hits found

912192 #N/A pir||C82602 hypothetical protein XF2068

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 6653 PL-3771.1 912254 to 403 (strain 9a5c) gb| AAF84867. l| AE004023_3

912709 (AΞ004023) hypothetical protein [Xylella fastidiosa] SEQ ID n~2949

Contig9 from ref |NP_052451.l] yacB [Plasmid ColIb-P9] SEQ ID n° 6654 PL-4294.1 912706 to 51% dbj |BAA75090.l| (AB021078) yacB [Plasmid Collb-

913023 P9] #N/A Contig9 from gb|AAG57655.l|AE005484_5 (AE005484) ferredoxin SEQ ID n° 6655 PL-1297.1 913329 to m 603 reductase subunit of phenylpropionate

914513 dioxygenase [Escherichia coli 0157 :H7] SEQ ID n~370 sp|P17295|MPCl_ALCEU METAPYROCATECHASE 1

(CAT02ASE) (CATECHOL , 3 -DIOXYGENASE I)

Contig9 from pir||si0l54 catechol 2 , 3 -dioxygenase (EC SEQ ID n° 6656 PL-1296.1 914515 to 593

1.13.11.2 I - Alcaligenes eutrophus

915468 emb |CAA36665. l| (X52414) metapyrocatechase (AA .

313) [Ralstonia eutropha] SEQ ID n-369 gb|AAG57654 l|AΞ005484_4 (AE005484) 2,3-

Contig9 from dihydroxy-2 , 3 -dihydrophenylpropionate SEQ ID n° 6657 PL-1295.1 915458 to 683 dehydrogenase [Escherichia coli

916300

0157:H7] SEQ ID n~368

TABLEAU II

sp | 77266 | HCAC_ECOLI 3- HENYLPROPIONATE

DIOXYGENASE FERREDOXIN SUBUNIT (DIGOXIGENIN

FERREDOXIN SUBUNIT) pir| |C65031 biphenyl dioxygenase (EC 1.14.12.-) Rieske iron-sulfur component b2540 - Escherichia coli

(strain K-12) gb |AAC75593.1 | (AE000340)

Contig9 from ferredoxin subunit of phenylpropionate

SEQ ID n° 6658 PL-4293.1 916300 to m 793 dioxygenase [Escherichia coli K12] 916617 dbj | BAA16443.1 | (D90884 ) BIPHENYL DIOXYGENASE

SYSTEM FERREDOXIN COMPONENT.

[Escherichia coli] emb|CAA71950. l| (Y11070) ferredoxin [Escherichia coli] gb[AAG57653.l|AE005484_3 (AE005484) ferredoxin subunit of phenylpropionate dioxygenase

[Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG57652.l]AE005484_2 (AE005484) small

SEQ ID n° 6659 PL-3770.1 916617 to m 73% terminal subunit of phenylpropionate dioxygenase

917159 [Escherichia coli 0157 :H7] SEQ ID n~2948 sp | Q47139 | HCAE_ECOLI 3 -PHENYLPROPIONATE

DIOXYGENASE ALPHA SUBUNIT (DIGOXIGENIN ALPHA

SUBUNIT) pir| |A65031 biphenyl dioxygenase (EC

1.14.-.-) terminal oxygenase component large chain - Escherichia coli gb| AAC75591.1]

Contig9 from (AE000340) large terminal subunit of

SEQ ID n° 6660 PL-1294.1 917156 to 89% phenylpropionate dioxygenase

918517 [Escherichia coli K12] dbj |BAA16441.1 | (D90884)

BENZENE 1,2-DIOXYGENASE ALPHA SUBUNIT (EC

1.14.12.3). [Escherichia coli] gb|AAG57651.l|AE005484_l (AE005484) large terminal subunit of phenylpropionate dioxygenase

[Escherichia coli 0157 :H7] SEQ ID n~367

Contig9 from gb|AAG57650.l|AE005483_9 (AE005483) SEQ ID n° 6661 PL-1293.1 918654 to 66% transcriptional activator of hca cluster

919538 [Escherichia coli 0157 :H7] SEQ ID n~366

TABLEAU II

Contig9 from gb|AAF81825.l|AF274045_4 (AF274045) 2-hydroxy-6-

SEQ ID n° 6662 PL-1292.1 919655 to 60% ketonona-2,4-dienedoic acid hydrolase,- OhpC

920554 [Rhodococcus sp . ] SEQ ID n~365

Contig9 from gb|AAG17135.l|AF190463_8 (AF190463) 2-OXO-4-

SEQ ID n° 6663 PL-1291.1 920624 to 64% pentenoate hydratase [Coma onas sp. JS765]

921406 SEQ ID n~364

Contig9 from gb|AAC77368.l| (AF058285)

SEQ ID n° 6664 PL-1290.1 921756 to m 473 nicotinamidase/pyrazinamidase [Mycobacterium

923099 smegmatis] SEQ ID n~363 sp|Q00538|MMR_BACSU METHYLENOMYCIN A RESISTANCE

PROTEIN (MMR PEPTIDE) pir| | YTBSMA methylenomycin A résistance protein mmr -

Contig9 from

Bacillus subtilis emb] CAA46908.1 | (X66121)

SEQ ID n° 6665 PL-1289.1 923099 to 523 methylenomycinAresistance protein [Bacillus

924484 subtilis] emb|CAB15784.l| (Z99123) methylenomycin A résistance protein [Bacillus subtilis] SEQ ID n-361 pir| |B82018 phosphoribosylamine--glycine ligase

(EC 6.3.4.13) NMA0238 [imported] -

Contig9 from

Neisseria meningitidis (group A strain

SEQ ID n° 6666 PL-1288.1 924511 to 593

Z2491) emb|CAB83546.l] (AL162752)

925773 phosphoribosylamine- -glycine ligase [Neisseria meningitidis Z2491] SEQ ID n~360

Contig9 from emb|CAC11141.l| (AJ250581) NikS protein

SEQ ID n° 6667 PL-1287.1 925814 to 473 [Streptomyces tendae]

927001 SEQ ID n~S59

Contig9 from ref ]NP_053211.l| pX02-56 [Bacillus anthracis]

SEQ ID n° 6668 PL-1286.1 927010 to m 353 gb|AAF13661.l|AF188935_59 (AF188935) pX02-56

927903 [Bacillus anthracis] SEQ ID n~358

Contig9 from

SEQ ID n° 6669 PL-4290.1 927875 to No Hits found

928111 #N/A

Contig9 from emb|CAB95928.l| (AL359989) putative

SEQ ID n° 6670 PL-3769.1 928147 to 323 acetyltransferase [Streptomyces coelicolor

928587 A3 (2)] SEQ ID n~2946

TABLEAU II

pir| |G83493 hypothetical protein PA1213

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 6671 PL-1285.1 928636 to m 303 (strain PAOl) g |AAG04602.1 | AE004551_6

929643 (AE004551) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~357

Contig9 from

SEQ ID n° 6672 PL-1284.1 929654 to m 253 gb|AAD00512.2| (U81376) PaaA [Erwinia herbicola]

930772 SEQ ID n~356

Contig9 from dbj |BAB04638.l| (AP001510) diaminobutyric acid

SEQ ID n° 6673 PL-1283.1 930775 to 25% aminotransferase [Bacillus

934194 halodurans] SEQ ID n~355

Contig9 from gb|AAG17135.l|AF190463_8 (AF190463) 2-OXO-4-

SEQ ID n° 6674 PL-4289.1 934849 to 593 pentenoate hydratase [Comamonas sp. JS765]

935169 #N/A sp|P42594|YGJM_EC0LI HYPOTHETICAL 15.0 KD

PROTEIN IN EBGC-UXAA INTERGENIC REGION

Contig9 from pir| |G65096 hypothetical protein ygjM - SEQ ID n° 6675 PL-4288.1 935206 to 70% Escherichia coli (strain K-12) gb |AAA57883. l|

935610 (U18997) ORF_fl38 [Escherichia coli] gb|AAC76117.l| (AE000390) orf, hypothetical protein [Escherichia coli K12] #N/A

Contig9 from pir| |T00236 protein KfrAs - Escherichia coli

SEQ ID n° 6676 PL-4287.1 935697 to m 41% plasmid p0157

935867 #N/A

Contig9 from gb|AAF74779.l|AF265211__4 (AF265211) indigoidine

SEQ ID n° 6677 PL-1282.1 935908 to 723 systhesis protein IdgA [Pectobacterium

936864 chrysanthemi] SEQ ID n~354

Contig9 from emb| CAB87990.1] (AJ277403) indigoidine synthase

SEQ ID n° 6678 PL-1281.1 936951 to 643 [Erwinia chrysanthemi]

940805 SEQ ID n-353

Contig9 from emb|CAB45045.1 | (AL078635) hypothetical protein

SEQ ID n° 6679 PL-1280.1 941134 to 18% [Amycolatopsis orientalis]

942312 SEQ ID n~352

Contig9 from gb|AAK05853.l|AE006405_7 (AΞ006405) UNKNOWN

SEQ ID n° 6680 PL-4286.1 942328 to m 513 PROTEIN [Lactococcus lactis subsp. lactis]

942765 #N/A

TABLEAU II

Contig9 from gb|AAK05853.l|AE006405_7 (AE006405) UNKNOWN SEQ ID n° 6681 PL-3768.1 942765 to m 423 PROTEIN [Lactococcus lactis subsp. lactis]

943241 SEQ ID n~2945 Contig9 from gb|AAF74780.l|AF265211_5 (AF265211) indigoidine SEQ ID n° 6682 PL-1279.1 943238 to m 563 systhesis protein IdgB [Pectobacterium

943906 chrysanthemi] SEQ ID n~350 Contig9 from gb|AAG56310.l[AE005360_2 (AE005360) ydcE gène SEQ ID n° 6683 PL-4285.1 943947 to m 593 product [Escherichia coli 0157 :H7]

944171 #N/A Contig9 from gb|AAG48136.l| (AF322179) nikko ycin SEQ ID n° 6684 PL-1278.1 944258 to m 663 biosynthesis protein SanR [Streptomyces

944914 ansochromogenes] SEQ ID n~349 Contig9 from gb|AAF73870.l|AF220669_2 (AF220669) fumarate SEQ ID n° 6685 PL-1277.1 945430 to p 913 nitrate réduction regulatory protein

946185 [Klebsiella pneumoniae] SEQ ID n~348 sp|P03807|YDAA_ECOLI 35.6 KDA PROTEIN IN TPX-FNR

INTERGENIC REGION pir| | QQECX membrane protein ydaA - Escherichia coli dbj | BAA14926.1 ]

(D90771) ORF_ID:o261#5~similar to [SwissProt

Accession Number P44195] [Escherichia

Contig9 from coli] dbj ]BAA14936.l| (D90772) SEQ ID n° 6686 PL-1276.1 946321 to p 803

ORF_ID:θ261#5-similar to [SwissProt Accession

947265

Number P44195] [Escherichia coli] gb|AAC74415.l| (AE000231) orf, hypothetical protein [Escherichia coli K12] gb|AAG56467.l|AE005373_l (AE005373) orf, hypothetical protein [Escherichia coli θl57:H7] SEQ ID n~347

Contig9 from gb|AAA87858.2 | (U40842) urease accessory protein

SEQ ID n° 6687 PL-1275.1 947323 to 763 [Yersinia pseudotuberculosis]

948288 SEQ ID n~346

Contig9 from sp|P4287l|URΞG_YEREN UREASE ACCESSORY PROTEIN

SEQ ID n° 6688 PL-1274.1 948285 to 913 UREG gb|AAA50999.l| (L24101) urease [Yersinia

948920 enterocolitica] SEQ ID n~345

Contig9 from gb|AAA87856.2 | (U40842) urease accessory protein

SEQ ID n° 6689 PL-1273.1 948973 to 723 [Yersinia pseudotuberculosis]

949659 SEQ ID n~344

TABLEAU II

Contig9 from gb|AAA87855.2 | (U40842) urease accessory protein SEQ ID n° 6690 PL-1272.1 949656 to m 683 [Yersinia pseudotuberculosis]

950252 SEQ ID n~343 Contig9 from sp|P31494|URΞl_YEREN UREASE ALPHA SUBUNIT (UREA SEQ ID n° 6691 PL-1271.1 950327 to 913 AMIDOHYDROLASE) gb | AA50996.1 | (L24101) urease

952042 alpha subunit [Yersinia enterocolitica] SEQ ID n-342 sp|P52314|URE2_YΞRPS UREASE BETA SUBUNIT (UREA

Contig9 from AMIDOHYDROLASE) gb |AAA87853.1 | (U40842) urease SEQ ID n° 6692 PL-4283.1 952110 to m 75? beta subunit [Yersinia pseudotuberculosis]

952499 gb|AAC78633.l| (AF095636) urease beta subunit

UreB [Yersinia pestis] #N/A sp|Q9ZFS0|URE3_YERPE UREASE GAMMA SUBUNIT (UREA

AMIDOHYDROLASE) sp | P52315 |URE3_YERPS UREASE

GAMMA SUBUNIT (UREA AMIDOHYDROLASE)

Contig9 from emb|CAA79314.l| (Z18865) YeuA [Yersinia SEQ ID n° 6693 PL-4282.1 952591 to m 74? enterocolitica] gb|AAC78632.l| (AF095636)

952893 urease gamma subunit UreA [Yersinia pestis] gb|AAA87852.2 | (U40842) urease gamma subunit

[Yersinia pseudotuberculosis] #N/A

Contig9 from gb|AAG31202.l|AF020810_3 (AF020810) NxiA SEQ ID n° 6694 PL-1270.1 953386 to p 783 [Salmonella enterica]

954411 SEQ ID n~341 pir| |A82603 hypothetical protein XF2074

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 6695 PL-4279.1 954803 to p 533 (strain 9a5c) gb|AAF84873.1 | AE004023_9

955099 (AE004023) hypothetical protein [Xylella fastidiosa] #N/A

TABLEAU II

sp | PO7002 | PNTB_ECOLI NAD (P) TRANSHYDROGENASE

SUBUNIT BETA (PYRIDINE NUCLEOTIDE

TRANSHYDROGENASE SUBUNIT BETA) (NICOTINAMIDE

NUCLEOTIDE TRANSHYDROGENASE SUBUNIT

BETA) pir| | DEECXB NAD(P)+ transhydrogenase (B- specific) (EC 1.6.1.1) beta chain -

Escherichia coli emb|CAA46885.1 | (X66086) pyridine nucleotide transhydrogenase

[Escherichia coli] dbj |BAA15336. l| (D90802)

NAD(P)+ transhydrogenase (B-specific) (EC

Contigg from

1.6.1.1) b chain [Escherichia coli] SEQ ID n° 6696 PL-1269.1 955228 to m 943 dbj |BAA15341.1 | (D90803) NAD(P)+

956616 transhydrogenase (B-specific) (EC 1.6.1.1) b chain [Escherichia coli] gb|AAC74674.l| (AE000255) pyridine nucleotide transhydrogenase, beta subunit

[Escherichia coli K12] emb] CAB37090.1 | (X04195)

NAD(P) (+) transhydrogenase subunit beta

[Escherichia coli] gb |AAG56589. l|AE005383_11

(AE005383) pyridine nucleotide transhydrogenase, beta subunit [Escherichia coli

0157 : H7] SEQ ID n~339

TABLEAU II

sp|P0700l|PNTA_ΞCOLI NAD(P) TRANSHYDROGENASE

SUBUNIT ALPHA (PYRIDINE NUCLEOTIDE

TRANSHYDROGENASE SUBUNIT ALPHA) (NICOTINAMIDE

NUCLEOTIDE TRANSHYDROGENASE SUBUNIT

ALPHA) pir | | DEECXA NAD (P) + transhydrogenase (B- specific) (EC 1.6.1.1) alpha chain -

Escherichia coli emb | CAA46884.1 | (X66086) pyridine nucleotide transhydrogenase

Contig9 from [Escherichia coli] dbj | BAA15342.l| (D90803) SEQ ID n° 6697 PL-1268.1 956627 to 89% NAD(P)+ transhydrogenase (B-specific) (EC

958156 1.6.1.1) a chain [Escherichia coli] dbj |BAA15352.l| (D90804) NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) a chain [Escherichia coli] gb| AAC74675.1 | (AE000255) pyridine nucleotide transhydrogenase, alpha subunit

[Escherichia coli K12] emb ] CAB37089. l| (X04195)

NAD(P) (+) transhydrogenase subunit alpha

[Escherichia coli] SEQ ID n~338

Contig9 from gb|AAG56591.l|AE005384_l (AE005384) orf, SEQ ID n° 6698 PL-1267.1 958680 to 69% hypothetical protein [Escherichia coli 0157-.H7]

959633 SEQ ID n~337 pir| |E82128 acyl carrier protein VC2020

Contig9 from

[imported] - Vibrio cholerae (group Ol SEQ ID n° 6699 PL-4277.1 959708 to 653 strain N16961) gb |AAF95168. l| (AE004276) acyl

959950 carrier protein [Vibrio cholerae] #N/A sp | 067185 | FABH_AQUAE 3 -OXOACYL- [ACYL-CARRIER- PROTEIN] SYNTHASE III (BETA-KETOACYL-ACP

Contig9 from SYNTHASE III) (KAS III) pir||F70394 3-oxoacyl- SEQ ID n° 6700 PL-1266.2 960030 to m 373 [acyl-carrier-protein] synthase III - Aquifex

961178 aeolicus gb| AC07144. l| (AE000723) 3-oxoacyl- [acyl-carrier-protein] synthase III [Aquifex aeolicus] SEQ ID n~336

Contig9 from SEQ ID n° 6701 PL-1265.2 961179 to No Hits found

962126 SEQ ID n~335

TABLEAU II

Contig9 from gb|AAG56592.l|AE005384__2 (AE005384) putative SEQ ID n° 6702 PL-1264.2 963193 to 833 arginine/ornithine antiporter [Escherichia coli

964584 0157:H7] SEQ ID n~334 Contig9 from SEQ ID n° 6703 PL-4273.1 964739 to m No Hits found

964966 #N/A Contig9 from emb|CAB56657.l| (AL121596) putative hydrolase SEQ ID n° 6704 PL-1263.2 964973 to m 193 [Streptomyces coelicolor A3 (2)]

965809 SEQ ID n~333 Contig9 from gb|AAG58930.1 [ AE005604_7 (AE005604) putative SEQ ID n° 6705 PL-3765.1 966612 to 59% major fimbrial subuit [Escherichia coli

967142 0157:H7] SEQ ID n~2944 Contig9 from gb|AAG58276.l|AE005543_6 (AE005543) putative

SEQ ID n° 6706 PL-2808.1 967257 to 63% chaperone [Escherichia coli 0157 :H7]

967931 SEQ ID n~2019 sp|P43662|LPFC_SALTY OUTER MEMBRANE USHER

PROTEIN LPFC PRECURSOR pir| |C56271 OUter

Contig9 from membrane usher protein IpfC precursor - SEQ ID n° 6707 PL-2809.1 967969 to 593

Salmonella typhimurium

970509 gb|AAA73968.1] (U18559) IpfC gène product

[Salmonella typhimuriuml SEQ ID n~2020 sp|P21648|MRKD_KLEPN FIMBRIA ADHESIN PROTEIN

PRECURSOR pir| |B32801 fimbrial adhesin

Contig9 from precursor, type 3 - Klebsiella pneumoniae SEQ ID n° 6708 PL-2810.1 970529 to 41% gb|AAA25096.l] (M55912) mrkD [Klebsiella

971521 pneumoniae] gb| AAA25098. l| (M24536) fimbrial adhesin [Klebsiella pneumoniae] SEQ ID n~2022

Contig9 from SEQ ID n° 6709 PL-4270.1 971636 to m No Hits found

971956 #N/A Contig9 from SEQ ID n° 6710 PL-4269.1 971956 to m No Hits found

972204 #N/A Contig9 from SEQ ID n° 6711 PL-4268.1 972616 to No Hits found

972876 #N/A

TABLEAU II

Contig9 from gb|AAF19774.l|AF128451_l (AF128451) repeat motif

SEQ ID n° 6712 PL-2812.1 973067 to m 323 protein bdrAδ [Borrelia turicatae]

973810 SEQ ID n~2024

Contig9 from

SEQ ID n° 6713 PL-3764.1 973923 to m No Hits found

974375 SEQ ID n~2943

Contig9 from gb|AAG56366.l|AE005364_ll (AE005364) helicase,

SEQ ID n° 6714 PL-2813.1 974544 to m 893 ATP-dependent [Escherichia coli 0157 :H7]

978287 SEQ ID n~2025 sp|P41407|ACPD_ECOLI ACYL CARRIER PROTEIN

PHOSPHODIESTERASE (ACP PHOSPHODIESTERASE) pir| |G64892 [acyl-carrier-protein] phosphodiesterase (EC 3.1.4.14) acpD -

Escherichia coli dbj |BAA15024.l| (D90779) Acyl

Contig9 from carrier protein phosphodiesterase (ACP SEQ ID n° 6715 PL-2814.1 978578 to 803 phosphodiesterase) (fragment) . [Escherichia

979180 coli] dbj |BAA15028.l| (D90780) Acyl carrier protein phosphodiesterase (ACP phosphodiesterase) (fragment) . [Escherichia coli] gb|AAC74494.l| (AE000238) acyl carrier protein phosphodiesterase [Escherichia coli

K12] SEQ ID n~2026

Contig9 from gb|AAG56377.l|AE005366_3 (AE005366) ydbL gène

SEQ ID n° 6716 PL-4267.1 979248 to 713 product [Escherichia coli 0157 :H7]

979574 #N/A sp|P76075|YNBE_ECOLI HYPOTHETICAL 6.8 KD PROTEIN

Contig9 from IN LDHA-FEAR INTERGENIC REGION pir| JA64889 ynbE

SEQ ID n° 6717 PL-4266.1 979587 to m 66% protein precursor - Escherichia coli

979784 gb|AAC74464.l| (AE000235) orf , hypothetical protein [Escherichia coli K12] #N/A

TABLEAU II

sp|P52645|YDBH_ECOLI HYPOTHETICAL 96.8 KDA

PROTEIN IN LDHA-TYNA INTERGENIC REGION pir| |H64888 membrane protein ydbH - Escherichia

Contig9 from coli dbj |BAA14991.1 | (D90776) ORF_ID:θ265#2 ; SEQ ID n° 6718 PL-2815.2 979781 to m 623 similar to [SwissProt Accession Number

982408

P52645] [Escherichia coli] gb|AAC74463.l|

(AE000235) orf, hypothetical protein

[Escherichia coli K12] SEQ ID n~2027

Contig9 from gb|AAG56380.l|AE005366_6 (AE005366) fermentative SEQ ID n° 6719 PL-2442.2 982775 to p 753 D-lactate dehydrogenase, NAD-dependent

983779 [Escherichia coli 0157 :H7] SEQ ID n~1622 sp|P52644|HSLJ_EC0LI HEAT SHOCK PROTEIN HSLJ pir[[F64888 heat shock protein precursor hslJ -

Escherichia coli dbj |BAA14984.l| (D90775) Heat

Contig9 from shock protein HslJ. [Escherichia coli] SEQ ID n° 6720 PL-4265.1 983801 to p 603 dbj |BAA14989.l| (D90776) Heat shock protein

984214

HslJ. [Escherichia coli] gb|AAC74461. l|

(AE000235) heat shock protein hslJ [Escherichia coli K12] #N/A

Contig9 from SEQ ID n° 6721 PL-2441.1 984538 to No Hits found

985158 SEQ ID n~î621 Contig9 from SEQ ID n° 6722 PL-2440.1 985352 to m No Hits found

985993 SEQ ID n~î620 Contig9 from

Sp|P76005|YCGN_ECOLI HYPOTHETICAL 17.9 KD SEQ ID n° 6723 PL-4264.1 986299 to 853 PROTEIN IN MINC-SHEA INTERGENIC REGION

986730 #N/A sp|P76004 |YCGM_ECOLI PROTEIN YCGM pir||A64864 probable 2 -hydroxyhepta-2 , 4 -diene-l , 7-dioate isomerase bll80 - Escherichia coli

Contig9 from gb | AAC74264 . l | (AE000216) putative isomerase SEQ ID n° 6724 PL-2439.1 986755 to m 80%

[Escherichia coli K12] dbj | BAA36014 . 1 | (D90751)

987411

ZK688 .3 protein [Escherichia coli] dbj | BAA36027 . l | (D90752) ZK688 .3 protein

[Escherichia coli] SEQ ID n-î.618

TABLEAU II

Contig9 from SEQ ID n° 6725 PL-4263.2 987694 to No Hits found

987798 #N/A sp|P76003|YCGL_ECOLI PROTEIN YCGL pir||H64863 ycgL protein - Escherichia coli gb|AAC74263.1 |

(AEO 00216) orf, hypothetical protein

Contig9 from [Escherichia coli K12] dbj |BAA36013.1 | (D90751) SEQ ID n° 6726 PL-4262.1 987763 to m 663 Hypothetical protein HI1446 [Escherichia coli]

988059 dbj |BAA36026.l| (D90752) Hypothetical protein

HI1446 [Escherichia coli] gb|AAG56030.l|AE005335_3 (AE005335) orf, hypothetical protein [Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG56027.l|AE005334_14 (AΞ005334) cell SEQ ID n° 6727 PL-2438.1 988180 to 78% division inhibitor, inhibits ftsZ ring formation

988863 [Escherichia coli 0157 :H7] SEQ ID n-î.617 sp|P18197|MIND_ECOLI SEPTUM SITE-DETERMINING

PROTEIN MIND (CELL DIVISION INHIBITOR MIND) pir| |CCECID cell division inhibitor minD -

Escherichia coli gb| AAB59062.1 | (J03153) MinD protein [Escherichia coli] dbj |BAA36009.1 |

(D90751) Cell division inhibitor MinD.

Contig9 from

[Escherichia coli] dbj |BAA36022.1 | (D90752) SEQ ID n° 6728 PL-2437.1 988887 to 903

Cell division inhibitor MinD. [Escherichia coli]

989699 gb|AAC74259.l| (AE000216) cell division inhibitor, a membrane ATPase, activâtes minC [Escherichia coli K12] gb|AAG56026.l|AE005334_13 (AΞ005334) cell division inhibitor, a membrane ATPase, activâtes minC [Escherichia coli 0157 :H7] SEQ ID n-î.616

TABLEAU II

sp|P18198|MINE_ECOLI CELL DIVISION TOPOLOGICAL

SPECIFICITY FACTOR pir| | CEECTF cell division topological specificity factor - Escherichia coli gb|AAB59063.l| (J03153) MinE protein

[Escherichia coli] dbj |BAA36008.1 | (D90751)

Cell division topological specificity factor.

[Escherichia coli] dbj |BAA36021.l| (D90752)

Contig9 from

Cell division topological specificity factor. SEQ ID n° 6729 PL-4261.1 989703 to 853

[Escherichia coli] gb | AAC74258.1 | (AE000216)

989972 cell division topological specificity factor, reverses MinC inhibition of ftsZ ring formation [Escherichia coli K12] gb|AAG56025.l|AE005334_12 (AE005334) cell division topological specificity factor, reverses MinC inhibition of ftsZ ring formation [Escherichia coli 0157 :H7] #N/A sp|P09155|RND_ECOLI RIBONUCLEASE D (RNASE D) pir| |NRECD ribonuclease III (EC 3.1.26.3) rnd -

Escherichia coli emb |CAA30098.l| (X07055) ribonuclease D (AA 1-375) (start codon uug)

Contig9 from [Escherichia coli] dbj |BAA15599.1 | SEQ ID n° 6730 PL-2436.1 990113 to 773 (D90823) Ribonuclease D (EC 3.1.13.-)

991240 [Escherichia coli] dbj |BAA15608.1 | (D90824)

Ribonuclease D (EC 3.1.13.-) [Escherichia coli] gb|AAC74874.1] (AE000274) RNase D, processes tRNA precursor [Escherichia coli K12] prf | | 1410308A ribonuclease D [Escherichia coli] SEQ ID n~î615

Contig9 from gb|AAG56794.l|AE005403_5 (AE005403) acyl-CoA

SEQ ID n° 6731 PL-2435.1 991336 to 35% synthetase, long-chain-fatty-acid--CoA ligase

993018 [Escherichia coli 0157 :H7] SEQ ID n~î614

Contig9 from

SEQ ID n° 6732 PL-4258.1 993473 to No Hits found

993598 #N/A

Contig9 from

SEQ ID n° 6733 PL-4257.1 993689 to No Hits found

993808 #N/A

TABLEAU II

pir||F64941 rnd protein - Escherichia coli db |BAA15610.l| (D90824) Outer membrane protein

Contig9 from SLP precursor. [Escherichia coli] SEQ ID n° 6734 PL-2434.1 993885 to m 613 dbj |BAA15615.l| (D90825) Outer membrane protein

994463 SLP precursor. [Escherichia coli] gb |AAC74876.l| (AE000275) putative outer membrane protein [Escherichia coli K12] SEQ ID n-H.613

Contig9 from gb|AAG56796.l|AE005403_7 (AE005403) orf, SEQ ID n° 6735 PL-2433.1 994547 to m 783 hypothetical protein [Escherichia coli 0157 :H7]

995242 SEQ ID n-î.612 pir| |A81032 helix-turn-helix family protein

NMB1891 [imported] - Neisseria

Contig9 from meningitidis (group B strain MD58) SEQ ID n° 6736 PL-4256.1 995475 to 72% gb|AAF42225.l| (AE002538) helix-turn-helix

995792 family protein [Neisseria meningitidis

MC58] #N/A pir] |C81975 hypothetical protein NMA0565

Contig9 from [imported] - Neisseria meningitidis SEQ ID n° 6737 PL-4255.1 995785 to m 69% (group A strain Z2491) emb | CAB83857.1 |

996159 (AL162753) hypothetical protein NMA0565

[Neisseria meningitidis Z2491] #N/A

Contig9 from gb|AAG56797.l|AE005403_8 (AE005403) putative SEQ ID n° 6738 PL-2432.2 996426 to m 85% enzyme [Escherichia coli 0157 :H7]

998348 SEQ ID n-î.611 Contig9 from gb|AAG56798.l|AE005404_l (AE005404) Orf, SEQ ID n° 6739 PL-4254.1 998449 to p 70% hypothetical protein [Escherichia coli 0157 :H7]

998793 #N/A Contig9 from SEQ ID n° 6740 PL-4253.1 999098 to p No Hits found

999430 #N/A Contig9 from SEQ ID n° 6741 PL-3763.1 999459 to p No Hits found

999920 SEQ ID n-2942 Contig9 from SEQ ID n° 6742 PL-4252.1 1000287 to p No Hits found

1000523 #N/A

TABLEAU II

sp|P77670|YDGE_ECOLI HYPOTHETICAL 11.7 KDA

PROTEIN IN ASR-PNTB INTERGENIC REGION pir| |A64916 probable membrane protein bl599 -

Escherichia coli dbj |BAA15333. l| (D90802)

Putative ethidium bromide résistance protein (El

Contig9 from protein) . [Escherichia coli] SEQ ID n° 6743 PL-4251.1 1000677 to m 803 dbj |BAA15338.l] (D90803) Putative ethidium

1001006 bromide résistance protein (El protein) .

[Escherichia coli] gb|AAC74671.l| (AE000255) possible chaperone [Escherichia coli K12] gb|AAG56586.l|AE005383_8 (AE005383) possible chaperone [Escherichia coli 0157 :H7] #N/A sp|P77412 |YDGF_ΞCOLI HYPOTHETICAL 13.1 KDA

PROTEIN IN ASR-PNTB INTERGENIC REGION pir| ]B64916 probable membrane protein bl600 -

Escherichia coli dbj |BAA15334. l] (D90802)

Putative ethidium bromide résistance protein (El

Contig9 from protein) . [Escherichia coli]

SEQ ID n° 6744 PL-3762.1 1001011 to 563 dbj |BAA15339.l| (D90803) Putative ethidium

1001427 bromide résistance protein (El protein) .

[Escherichia coli] gb| AAC74672.1 | (AE000255) possible chaperone [Escherichia coli K12] gb|AAG56587.l|AE005383_9 (AE005383) possible chaperone [Escherichia coli 0157:H7] SEQ ID n~2941 sp|P37986|G6PD_ERWCH GLUCOSE-6-PHOSPHATE 1-

DEHYDROGENASE (G6PD) pir||S37053 glucose-6-

Contigθ from phosphate 1-dehydrogenase (EC 1.1.1.49) - SEQ ID n° 6745 PL-2431.1 1001926 to 87%

Erwinia chrysanthemi emb|CAA52858.1 |

1003401

(X74856) glucose-6-phosphate 1-dehydrogenase

[Erwinia chrysanthemi] SEQ ID n~ï610

Contig9 from gb|AAG56843.l|AE005408_l (AE005408) orf, SEQ ID n° 6746 PL-2429.1 1003746 to 873 hypothetical protein [Escherichia coli 0157:H7]

1004606 SEQ ID n-1607 Contig9 from pir||S18689 Sc/SvP protein - Escherichia coli SEQ ID n° 6747 PL-2428.1 1005079 to 41% plasmid pl5B emb | CAA44052. l| (X62121) DNA

1005981 inversion product [Escherichia coli] SEQ ID n~î606

TABLEAU II

Contig9 from gb|AAG54576.l|AE005203_5 (AE005203) unknown

SEQ ID n° 6748 PL-2427.1 1006376 to 17% protein from prophage CP-933H [Escherichia coli

1007389 0157 :H7] SEQ ID n~î605

Contig9 from

SEQ ID n° 6749 PL-4249.1 1007434 to No Hits found

1007634 #N/A sp|P21599|KPY2_ECOLI PYRUVATE KINASE II (PK-2) pir||S29790 pyruvate kinase (EC 2.7.1.40) A -

Escherichia coli gb| AAA24473.l| (M63703)

Contig9 from pyruvate kinase type II [Escherichia coli] SEQ ID n° 6750 PL-2426.1 1008005 to 913 dbj |BAAl5662.l| (D90828) Pyruvate kinase (EC

1009447

2.7.1.40) [Escherichia coli] gb|AAC74924.l|

(AEO00279) pyruvate kinase II, glucose stimulated [Escherichia coli K12] SEQ ID n~î604

Contig9 from gb|AAG56845.l|AE005408_3 (AE005408) suppressor SEQ ID n° 6751 PL-2425.1 1009648 to m 683 of htrB, heat shock protein [Escherichia coli

1010616 0157 :H7] SEQ ID n-1603 sp|P24204|YEBA_ECOLI HYPOTHETICAL 46.7 KD

PROTEIN IN MSBB-RUVB INTERGENIC REGION (ORFU)

Contig9 from pir| |H64947 membrane protein yebA - Escherichia SEQ ID n° 6752 PL-2424.1 1010768 to m 723 coli dbj |BAA15664.l| (D90828) Lysostaphin

1012075 precursor (EC 3.5.1.-). [Escherichia coli] gb|AAC74926.l| (AE000279) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~2602

Contig9 from gb|AAG56847.l|AE005408_5 (AE005408) putative SEQ ID n° 6753 PL-2423.1 1012096 to m 713 adhesin [Escherichia coli 0157 :H7]

1013043 SEQ ID n-ï.601 sp|P52648|ZNUC_EC0LI HIGH-AFFINITY ZINC UPTAKE SYSTEM ATP-BINDING PROTEIN ZNUC pir| |B64948 probable ABC transport system ATP-binding

Contig9 from protein yebM - Escherichia coli SEQ ID n° 6754 PL-2422.1 1013096 to 753 dbj |BAA15666.l| (D90828) Sulfate transport ATP-

1013893 binding protein CysA. [Escherichia coli] gb|AAC74928.l| (AE000280) putative ATP- binding component of a transport system [Escherichia coli K12] SEQ ID n~∑600

TABLEAU II

sp|P39832|ZNUB_ECOLI HIGH-AFFINITY ZINC UPTAKE

SYSTEM MEMBRANE PROTEIN ZNUB pir| |C64948 probable membrane protein yebl - Escherichia coli dbj |BAA15667.l| (D90828)

Contig9 from ORF_ID:θ336gap#12; similar to [SwissProt SEQ ID n° 6755 PL-2421.1 1013890 to 903 Accession Number P39832] [Escherichia

1014675 coli] dbj |BAA15670.l| (D90829)

ORF_ID:o336gap#12~similar to [SwissProt

Accession Number P39832] [Escherichia

COli] gb|AAC74929.l| (AE000280) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~2599

Sp|P08577|RUVB_ECOLI HOLLIDAY JUNCTION DNA

HELICASE RUVB pir| |BVECVB DNA-binding protein ruvB - Escherichia coli emb |CAA30120. l|

(X07091) ruvB gène product (AA 1 - 336)

[Escherichia coli] gb|AAA24613.l| (M21298) ruvB protein [Escherichia coli] dbj ]BAA15671.1 |

Contig9 from

(D90829) Holliday junction DNA helicase RuvB. SEQ ID n° 6756 PL-2420.1 1014889 to m 893

[Escherichia coli] gb|AAC74930.1 | (AE000280)

1015896

Holliday junction helicase subunit A; branch migration; repair [Escherichia coli

K12] gb|AAG56850.l|AE005408_8 (AE005408)

Holliday junction helicase subunit A; branch migration; repair [Escherichia coli

0157 : H7] SEQ ID n-1598

TABLEAU II

sp|P08576]RUVA_ECOLI HOLLIDAY JUNCTION DNA

HELICASE RUVA pir| ]BVECRV ruvA protein -

Escherichia coli pdb|lC7Y|A Chain A, E.Coli

Ruva-Holliday Junction Complex pdb|lHJP|

Holliday Junction Binding Protein Ruva From E.

Coli pdb|lBDX|A Chain A, E. Coli Ruva With

Bound Dna Holliday Junction, Alpha

Carbons And Phosphate Atoms Only pdb | 1BDX | B

Chain B, E. Coli Ruva With Bound Dna Holliday

Junction, Alpha Carbons And Phosphate

Contig9 from Atoms Only pdb|lBDX|c Chain C, Ξ. Coli Ruva

SEQ ID n° 6757 PL-2419.1 1015913 to m 853 With Bound Dna Holliday Junction, Alpha 1016530 Carbons And Phosphate Atoms Only pdb | 1BDX |D

Chain D, E. Coli Ruva ith Bound Dna Holliday

Junction, Alpha Carbons And Phosphate

Atoms Only gb | AAA24612.1 | (M21298) ruvA protein

(gtg start) [Escherichia coli] dbj |BAA15672. l|

(D90829) RuvA protein [Escherichia coli] gb|AAC74931.l| (AE000280) Holliday junction helicase subunit B; branch migration; repair [Escherichia coli K12] gb|AAG56851.l|AE005408_9 (AE005408) Holliday junction helicase subunit B; branch migration; SEQ ID n-î.596

TABLEAU II

sp|P24239|RUVC_EC0LI CROSSOVER JUNCTION

ENDODEOXYRIBONUCLEASE RUVC (HOLLIDAY JUNCTION

NUCLEASE RUVC) (HOLLIDAY JUCTION RESOLVASE RUVC) pir||D38H3 crossover junction endodeoxyribonuclease (EC 3.1.22.4) ruvC -

Escherichia coli emb| CAA42128.l| (X59551) ruvC

Contig9 from [Escherichia coli] dbj |BAA01032.l| (D10165)

SEQ ID n° 675E PL-3761.1 1016617 to m 883 RuvC [Escherichia coli] dbj |BAA15674.l| 1017138 (D90829) DNA repair protein RuvC [Escherichia coli] gb|AAC74933.l| (AE000280) Holliday junction nuclease; resolution of structures; repair [Escherichia coli K12] gb|AAG56853.l]AE005408_ll (AE005408) Holliday junction nuclease; resolution of structures; repair [Escherichia coli 0157:H7] SEQ ID n~2940

Contig9 from gb|AAG56854.l|AE005408_12 (AE005408) orf,

SEQ ID n° 6759 PL-2418.1 1017370 to 883 hypothetical protein [Escherichia coli 0157 :H7]

1018113 SEQ ID n~2595

Contig9 from emb|CAA42125.l| (X59551) alternative

SEQ ID n° 6760 PL-4244.1 1018143 to 80% [Escherichia coli] dbj |BAA01030.l| (D10165)

1018580 0rfl7 [Escherichia coli] #N/A sp|P21889|SYD_ECOLI ASPARTYL-TRNA SYNTHETASE

(ASPARTATE--TRNA LIGASE) (ASPRS) pir| | SYECD aspartate- -tRNA ligase (EC 6.1.1.12) -

Escherichia coli pdb[lEQR|A Chain A, Crystal

Structure Of Free Aspartyi-Trna Synthetase From

Escherichia Coli pdb|lΞQRJB Chain B, Crystal

Contig9 from Structure Of Free Aspartyi-Trna Synthetase From

SEQ ID n° 6761 PL-2417.1 1018580 to m 843 Escherichia Coli pdb|lEQR|c Chain C, Crystal 1020352 Structure Of Free Aspartyi-Trna Synthetase From

Escherichia Coli emb| CAA37856.1 | (X53863) aspartate-tRNA ligase [Escherichia coli] dbj |BAA15677.l| (D90829) Aspartate- -tRNA ligase

(EC 6.1.1.12) [Escherichia coli] gb ] AAC74936.1 |

(AE000280) aspartate tRNA synthetase

[Escherichia coli K12] SEQ ID n-î594

TABLEAU II

Contig9 from sp|P76289|YECN_ECOLI HYPOTHETICAL 15. KD SEQ ID n° 6762 PL-4243.1 1020629 to p 83% PROTEIN IN ASPS-BISZ INTERGENIC REGION

1021024 #N/A Contig9 from SEQ ID n° 6763 PL-4242.1

Contig9 from gb|AAC84003.l| (AF072126) stability protein StbD SEQ ID n° 6764 PL-4241.1 1021431 to m 77% [Morganella morganii]

1021682 #N/A Contig9 from gb|AAG56860.l|AE005409__5 (AΞ005409) orf, SEQ ID n° 6765 PL-2415.1 1021955 to p 78% hypothetical protein [Escherichia coli 0157 :H7]

1022713 SEQ ID n~ï592 Contig9 from gb|AAG56861.l|AE005409_6 (AE005409) putative SEQ ID n° 6766 PL-2414.1 1022710 to p 86% enzyme [Escherichia coli 0157 :H7]

1023681 SEQ ID n~î591 sp|P46719|CUTC_EC0LI COPPER HOMEOSTASIS PROTEIN

Contig9 from CUTC dbj |BAA15684.1 | (D90829) Copper SEQ ID n° 6767 PL-2413.2 1023857 to m 67% homeostasis protein CutC. [Escherichia coli]

1024603 dbj |BAA1569l.l| (D90830) Copper homeostasis protein CutC. [Escherichia coli] SEQ ID n-2.590

Contig9 from gb|AAG56865.l|AΞ005410__l (AE005410) orf, SEQ ID n° 6768 PL-4240.1 1024741 to m 46% hypothetical protein [Escherichia coli 0157 :H7]

1024908 #N/A pir| |D82455 hypothetical protein VCA0468

Contig9 from

[imported] - Vibrio cholerae (group SEQ ID n° 6769 PL-4239.1 1024954 to p 63%

01 strain N16961) gb | AF96372.1 | (AE004379)

1025289 hypothetical protein [Vibrio cholerae] #N/A pir| |E82455 conserved hypothetical protein

Contig9 from VCA0469 [imported] - Vibrio cholerae SEQ ID n° 6770 PL-4238.1 1025290 to p 68% (group Ol strain N16961) gb|AAF96373.1 |

1025604 (AE004379) conserved hypothetical protein

[Vibrio cholerae] #N/A

Contig9 from SEQ ID n° 6771 PL-2412.1 1025620 to m 61% sp|P52007|YECM_ECOLI PROTEIN YECM

1026183 SEQ ID n~î589

TABLEAU II

Contig9 from gb |AAD19708 . l | (AF123694 ) galactophilic lectin SEQ ID n° 6772 PL-3759.1 1027152 to 373

PA-I [Pseudomonas aeruginosa]

1027520 ³ SEQ ID n~2938 sp|P37904|YCEI_ECOLI PROTEIN YCEI PRECURSOR pir| |E64848 ycel protein precursor - Escherichia coli gb|AAC74140.l| (AΞ000207) orf, hypothetical protein [Escherichia coli K12]

Contig9 from dbj |BAA35854.l| (D90742) 18.7 kd protein in htrB

SEQ ID n° 6773 PL-3758.1 1027834 to 823

5 ' région precursor. [Escherichia

1028412 coli] dbj |BAA35865.l| (D90743) 18.7 kd protein in htrB 5 ' région precursor. [Escherichia coli] gb|AAG55802.l|AE005316_7 (AΞ005316) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~2937

Contig9 from gb |AAG55803 . l |AE005316_8 (AE005316) putative

SEQ ID n° 6774 PL-2411.1 1028439 to 633 cytochrome [Escherichia coli 0157 :H7]

1028993 SEQ ID n~î588

Contig9 from gb|AAK02181.l| (AEO 06045) unknown [Pasteurella

SEQ ID n° 6775 PL-2410.1 1029597 to 633 multocida]

1030334 SEQ ID n~î587 sp|P11875|SYR_ECOLI ARGINYL-TRNA SYNTHETASE (ARGININE- -TRNA LIGASE) (ARGRS) pir| | SYECRT arginine- -tRNA ligase (EC 6.1.1.19) [validated]

Escherichia coli emb| CAA33384.1 | (X15320)

Contig9 from arginyl-tRNA-synthetase (AA 1-577) [Escherichia

SEQ ID n° 6776 PL-2409.1 1030689 to 89% coli] dbj |BAA15686.l| (D90829) Arginine--tRNA

1032419 ligase (EC 6.1.1.19) [Escherichia coli] dbj |BAA15693.l| (D90830) Arginine- -tRNA ligase

(EC 6.1.1.19) [Escherichia coli] gb | AAC74946.1 |

(AE000281) arginine tRNA synthetase [Escherichia coli K12] SEQ ID n~î585 sp|P37169|MVIN_SALTY VIRULENCE FACTOR MVIN

Contig9 from pir| |S40271 virulence factor mviN - Salmonella

SEQ ID n° 6777 PL-2408.1 1032784 to m 88? typhimurium emb|CAA8113 .l| (Z26133) mviB 1034319 [Salmonella typhimurium] dbj | BAA04980.11

(D25292) ORF2 [Salmonella typhimurium] SEQ ID n~î584

TABLEAU II

Contig9 from

SEQ ID n° 6778 PL-4234.1 1035125 to No Hits found

1035328 #N/A

Contig9 from

SEQ ID n° 6779 PL-4233.1 1035353 to No Hits found

1035583 #N/A s | O9454 | IMJ_ECOLI RIBOSOMAL-PROTEIN-ALANINE

ACETYLTRANSFERASE (ACETYLATING ENZYME FOR

N-TERMINAL OF RIBOSOMAL PROTEIN S5) pir| ]S01084 ribosomal-protein-alanine N-acetyltransferase

(EC 2.3.1.128) rimJ - Escherichia coli emb |CAA29490.1] (X06118) S5 (AA 1-194)

[Escherichia coli] gb| AAA24549.1 | (M99278) acetylase [Escherichia coli] dbj |BAA35874. l|

Contig9 from

(D90743 ) Ribosomal-protein-alanine SEQ ID n° 6780 PL-3757.1 1035716 to 80% acetyltransferase (EC 2.3.1.128)

1036300

(acetylating enzyme for N-terminal of ribosomal protein S5) . [Escherichia coli] gb]AAC74150.l| (AE000207) acetylation of N- terminal alanine of 3 OS ribosomal subunit protein S5 [Escherichia coli K12] gb]AAG55812.1 | E005317_1 (AE005317) acetylation of N-terminal alanine of 3OS ribosomal subunit protein S5 [Escherichia coli 0157 :H7] SEQ ID n~2936 pir] |F64849 probable permease bl065 -

Escherichia coli gb|AAC74l49. l| (AE000207) orf,

Contig9 from hypothetical protein [Escherichia coli K12] SEQ ID n° 6781 PL-2407.1 1036489 to 85% dbj |BAA35873.l] (D90743) Hypothetical 44.7 kd

1037694 protein in glnQ-ansR intergenic région. [Escherichia coli] SEQ ID n-î.583

Contig9 from gb|AAG55809.l|AE005316_14 (AΞ005316) orf, SEQ ID n° 6782 PL-2406.1 1037732 to 66% hypothetical protein [Escherichia coli 0157 :H7]

1038295 SEQ ID n~î582

TABLEAU II

sp|P75915|YCDY_ECOLI HYPOTHETICAL 20.7 KDA

PROTEIN IN PHOH-CSGG INTERGENIC REGION pir] |H64845 ycdY protein - Escherichia coli

Contig9 from gb|AAC74119.1] (AΞ000205) putative SEQ ID n° 6783 PL-2405.1 1038486 to m 683 oxidoreductase component [Escherichia coli K12]

1039025 dbj |BAA35816.l| (D90740) Hypothetical protein

HI1543 [Escherichia coli] dbj |BAA35825. l|

(D90741) Hypothetical protein HI1543

[Escherichia coli] SEQ ID n~î581 sp|P75913 |YCDW_ECOLI PUTATIVE 2 -HYDROXYACID

DEHYDROGENASE IN PHOH-CSGG INTERGENIC REGION

Contig9 from pir||F64845 probable 2-hydroxyacid dehydrogenase SEQ ID n° 6784 PL-2404.1 1039098 to m 68% ycd - Escherichia coli gb| AAC74117. l|

1040039

(AE000205) putative dehydrogenase [Escherichia coli K12] SEQ ID n-1580 sp|P76125|YDDM_ECOLI HYPOTHETICAL 13.3 KD

Contig9 from PROTEIN IN FDNI-ADHP INTERGENIC REGION SEQ ID n° 6785 PL-4232.1 1040771 to p 72% pir] |H64900 hypothetical protein bl477 -

1041073 Escherichia coli gb] AAD13441. l| (AE000244) orf, hypothetical protein [Escherichia coli K12] #N/A sp|P44217|YE92_HAEIN HYPOTHETICAL PROTEIN HI1492

PRECURSOR pir| |B64032 hypothetical protein

Contig9 from

HI1492 - Haemophilus influenzae (strain Rd SEQ ID n° 6786 PL-2403.1 1041234 to m 39%

KW20) gb|AAC23144.l| (U32826) H. influenzae

1041815 predicted coding région HI1492 [Haemophilus influenzae Rd] SEQ ID n~î579

Contig9 from gb|AAA27621.l| (M90093) luxE [Xenorhabdus SEQ ID n° 6787 PL-2402.1 1041984 to m 943 luminescens] gb |AAG09983.11AF251497_1

1043096 (AF251497) LuxE [cloning vector HKBS1] SEQ ID n~ï578 pir] |C3541l alkanal monooxygenase (FMN-linked)

Contig9 from (EC 1.14.14.3) beta chain - SEQ ID n° 6788 PL-2401.1 1043158 to m 923 Xenorhabdus luminescens gb| AAA27627.1 | (M55977)

1044132 luciferase beta subunit [Xenorhabdus luminescens] SEQ ID n-3.577

TABLEAU II

sp|P19839|LXAl_PHOLU ALKANAL MONOOXYGENASE ALPHA

CHAIN (BACTERIAL LUCIFERASE ALPHA CHAIN) pir| |B35411 alkanal monooxygenase (FMN- linked) (EC 1.14.14.3) alpha chain -

Contig9 from Xenorhabdus luminescens gb | AAA27619. l| (M90093) SEQ ID n° 6789 PL-2400.1 1044150 to m 973 luciferase [Xenorhabdus luminescens]

1045229 gb[AAA27623. l[ (M57416) luciferase alpha subunit

[Xenorhabdus luminescens] gb|AAA27626.1 |

(M55977) luciferase alpha subunit [Xenorhabdus luminescens] gb|AAG09985.l|AF25l497_3

(AF251497) luciferase [cloning vector HKBS1] SEQ ID n~î576

Contig9 from pir| |D39853 acyltransferase (EC 2.3.1.' ) LuxD - SEQ ID n° 6790 PL-2399.1 1045406 to 95% Xenorhabdus luminescens

1046329 SEQ ID n-5.573 gb|AAA27617.l| (M90093) fatty acid reductase

Contig9 from

[Xenorhabdus luminescens] SEQ ID n° 6791 PL-2398.1 1046342 to 96% gb|AAG09987.l|AF251497_5 (AF251497) fatty acid

1047784 reductase [cloning vector HKBS1] SEQ ID n~î572

Contig9 from SEQ ID n° 6792 PL-4229.1 1048324 to m No Hits found

1048599 #N/A Contig9 from SEQ ID n° 6793 PL-4227.1 1048761 to No Hits found

1049045 #N/A sp|P74178 | YB78_SYNY3 HYPOTHETICAL 69.1 KD

Contig9 from PROTEIN SLL1178 pir| |S75808 nodulation protein SEQ ID n° 6794 PL-2397.1 1049367 to m 503 Synechocystis sp. (strain PCC 6803)

1051118 dbj |BAA18267.l| (D90913) nodulation protein

[Synechocystis sp . ] SEQ ID n~1571

Contig9 from gb|AAG34189.l|AF321122_8 (AF321122) Sim-nJ2 SEQ ID n° 6795 PL-2396.1 1051713 to 48% [Streptomyces antibioticus]

1052405 SEQ ID n~î570

TABLEAU II

sp|P40877|YCHM_ECOLI HYPOTHETICAL 58.4 KDA

PROTEIN IN PTH-PRSA INTERGENIC REGION pir||C64867 probable sulfate transport protein ychM - Escherichia coli gb|AAC74290.l|

Contig9 from

(AE000219) orf, hypothetical protein SEQ ID n° 6796 PL-2395.1 1053177 to 79?

[Escherichia coli K12] dbj |BAA36064.l| (D90756)

1054877

Hypothetical protein in pth-prsA intergenic région . [Escherichia coli] gb|AAG56064.l]AE005338_4 (AE005338) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n-ï569 sp|P17579|KDSA_ECOLI 2-DEHYDRO-3-

DEOXYPHOSPHOOCTONATE ALDOLASE

(PHOSPHO-2-DEHYDRO-3 -DEOXYOCTONATE ALDOLASE)

(3-DEOXY-D-MANNO-OCTULOSONIC ACID 8-PHOSPHATE

SYNTHETASE) (KDO-8 -PHOSPHATE SYNTHETASE) (KDO 8-

P SYNTHASE) pir||l83573 3-deoxy-D- manno-octulosonic acid 8 -phosphate synthetase -

Escherichia coli pir| |SYEC0L 2-dehydro-3- deoxyphosphooctonate aldolase (EC 4.1.2.16) -

Escherichia coli pdb|lD9E|A Chain A, Structure

Contig9 from

Of E. Coli Kdo8p Synthase pdb|lD9E|B Chain B,

SEQ ID n° 6797 PL-2394.1 1054993 to m 90^!

Structure Of Ξ . Coli Kdo8p Synthase pdb | 1D9E | C 1055847

Chain C, Structure Of E. Coli Kdo8p Synthase pdb]lD9E|D Chain D, Structure Of E. Coli Kdo8p

Synthase pdb|lGGθ|A Chain A, Crystal structure

Analysis Of Kdop Synthase At 3.0 A gb|AAC43441.l| (U18555) 3-deoxy-D-manno- octulosonic acid 8-phosphate synthetase

[Escherichia coli] dbj ] BAA36073.l| (D90756) 3- deoxy-D-manno-octulosonic acid 8-phosphate synthetase [Escherichia coli] dbj |BAA36083.l| (D90757) 3-deoxy-D-manno- SEQ ID n-î.568

TABLEAU II

sp|P2010l| CHA_ECOLI HYPOTHETICAL 30.8 KDA

PROTEIN IN HEMK-KDSA INTERGENIC REGION pir| | 183572 yehA protein - Escherichia coli gb|AAC43440.l| (U18555) orfl gène product

[Escherichia coli] gb |AAC74298.1 | (AE000219)

Contig9 from orf, hypothetical protein [Escherichia coli K12] SEQ ID n° 6798 PL-2393.1 1056003 to m 743 dbj |BAA3607 .1] (D90756) Hypothetical protein 1

1056812

(ksdA 3 ' région) [Escherichia coli] dbj |BAA36082.1 | (D90757) Hypothetical protein 1

(ksdA 3 ' région) [Escherichia coli] gb|AAG56072.l|AE005338_12 (AE005338) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~2567

Contig9 from gb|AAG56070.l|AE005338_10 (AE005338) possible

SEQ ID n° 6799 PL-2392.1 1056796 to m 73? protoporphyrinogen oxidase [Escherichia coli

1057644 0157:H7] SEQ ID n~ï566 sp|P0701l|RFl_ECOLI PEPTIDE CHAIN RELEASE FACTOR

1 (RF-1) ρir||FCECRl translation releasing factor RF-l - Escherichia coli dbj [BAA36069.1 |

Contig9 from (D90756) Peptide chain release factor 1 (rf-1) .

SEQ ID n° 6800 PL-2391.1 1057644 to m 92% [Escherichia coli] dbj |BAA36079.1 | (D90757)

1058726 Peptide chain release factor 1 (rf-1) .

[Escherichia coli] gb | AAC74295.l| (AΞ000219) peptide chain release factor RF-1 [Escherichia coli K12] SEQ ID n~î565

Contig9 from gb|AAG56068. l | AE005338_8 (AE005338) enzyme in SEQ ID n° 6801 PL-2390.1 1058758 to m 853 alternate path of synthesis of 5-

1060020 aminolevulinate [Escherichia coli 0157 :H7] SEQ ID n~£564

TABLEAU II

Sp]P24208|LOLB_ECOLI OUTER-MEMBRANE LIPOPROTEIN

LOLB PRECURSOR pir | [A47706 5-aminolevulinate synthase (EC 2.3.1.37) hemM - Escherichia coli gb|AAA24433.l| (M77237) ORF1 [Escherichia coli] dbj |BAA36067.l| (D90756) 22k hypothetical protein (3' of hemA) [Escherichia coli]

Contig9 from gb]AAC74293. l| (AE000219) an enzyme in main SEQ ID n° 6802 PL-2389.1 1060398 to 683 pathway of synthesis of 5-

1061024 aminolevulinate, possibly glutamyl-tRNA dehydrogenase [Escherichia coli K12] gb|AAG56067.l|AE005338_7 (AE005338) an enzyme in main pathway of synthesis of 5- aminolevulinate, possibly glutamyl-tRNA dehydrogenase [Escherichia coli

0157:H7] SEQ ID n-1562 sp| P24209 | ISPE_ECOLI 4-DIPHOSPHOCYTIDYL-2-C-

METHYL-D-ERYTHRITOL KINASE (CMK) (4-

(CYTIDINE-5' -DIPHOSPHO) -2-C-METHYL-D-ERYTHRITOL

KINASE) pir||B47706 yehB protein - Escherichia coli gb|AAA24434.l| (M77237) ORF2 [Escherichia coli] gb|AAC43434.ι| (U18555) orfY gène product

[Escherichia coli] gb|AAC74292.l| (AE000219) orf, hypothetical protein [Escherichia coli K12]

Contig9 from dbj |BAA36066.l| (D90756) 31k hypothetical SEQ ID n° 6803 PL-2388.1 1061024 to 75? protein (5' of prs) [Escherichia coli]

1061899 gb|AAF13867.l| (AF179284) isopentenyl monophosphate kinase [Escherichia coli] emb|CAB64963.l| (AJ249325) isopentenyl monophosphate kinase [Escherichia coli] gb|AAF29530.l|AF216300_l (AF216300) 4- diphosphocytidyl-2C-methyl-D-erythritol kinase

[Escherichia coli] dbj |BAA94247.1 | (AB037116) 4-

(cytidine-5 ' -diphospho) -2-C-methyl-D-erythrito 1 kinase [Escherichia coli] SEQ ID n~î561

TABLEAU II

sp | P08330 | KPRS_ECOLI RIBOSE-PHOSPHATE

PYROPHOSPHOKINASE (PHOSPHORIBOSYL PYROPHOSPHATE

SYNTHETASE) pir| | KIECRY ribose-phosphate pyrophosphokinase (EC 2.7.6.1) [validated] -

Contig9 from Escherichia coli gb|AAC74291.l| (AE000219) SEQ ID n° 6804 PL-2387.1 1061963 to 913 phosphoribosylpyrophosphate synthetase

1062910 [Escherichia coli K12] dbj |BAA36065.l| (D90756) Ribose-phosphate pyrophosphokinase (EC 2.7.6.1) (phosphoribosyl pyrophosphate synthetase) .

[Escherichia coli] SEQ ID n~î560 sp(P31807|YCHH_ECOLI HYPOTHETICAL 10.5 KDA

PROTEIN IN PTH-PRS INTERGENIC REGION

(ORF-2) pir] |B64867 probable membrane protein ychH - Escherichia coli emb|CAA43947.1 |

(X61941) ORF-2 [Escherichia coli]

Contig9 from gb|AAC74289.l| (AE000219) orf, hypothetical SEQ ID n° 6805 PL-4225.1 1063006 to 70? protein [Escherichia coli K12] dbj |BAA36063.1 |

1063281

(D90756) Hypothetical 10.5 kd protein in pth-prs intergenic région (orf-2) .

[Escherichia coli] gb| AAG56063. l| AE005338_3

(AE005338) orf, hypothetical protein

[Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG57041.l|AE005423_3 (AE005423) putative

SEQ ID n° 6806 PL-2386.1 1063761 to 323 invasin [Escherichia coli 0157 :H7]

1064729 SEQ ID n~î559

Contig9 from

SEQ ID n° 6807 PL-2385.2 1064844 to m No Hits found

1066169 SEQ ID n~î558

Contig9 from

SEQ ID n° 6808 PL-2383.1 1066936 to m No Hits found

1068534 SEQ ID n~ï557

Contig9 from

SEQ ID n° 6809 PL-2382.1 1068874 to m No Hits found

1070376 SEQ ID n-1556

TABLEAU II

Contig9 from

SEQ ID n° 6810 PL-2381.1 1070759 to m No Hits found

1072261 SEQ ID n~î555

Contig9 from

SEQ ID n° 6811 PL-2380.2 1072846 to No Hits found

1074348 SEQ ID n~î554

Contig9 from gb|AAG54632.l|AΞ005207_7 (AE005207) putative

SEQ ID n° 6812 PL-2379.1 1075148 to 353 adhesin [Escherichia coli 0157 :H7]

1080235 SEQ ID n~î552 ref |NP_050553.l| S [Bacteriophage Mu]

Contig9 from sp | Q9T1V0 | VPS_BPMU TAIL FIBER PROTEIN (GPS)

SEQ ID n° 6813 PL-2378.1 1080732 to gb|AAF01127.l|AF083977_46 (AF083977) S

1082672

[Bacteriophage Mu] SEQ ID n~ï551

Contig9 from sp|Q6000l|PTH_SALTI PEPTIDYL-TRNA HYDROLASE

SEQ ID n° 6814 PL-3756.1 1083076 to p 84% (PTH) gb|AAB06185.l| (U31571) peptidyl-tRNA

1083666 hydrolase [Salmonella typhi] SEQ ID n~2935 sp|P31216|YCHF_ECOLI PROBABLE GTP-BINDING

PROTEIN IN TREA-PTH INTERGENIC REGION (ORF-3) pir| |H64866 probable GTP-binding protein ychF -

Contig9 from

Escherichia coli gb| AAC74287. l| (AE000219) SEQ ID n° 6815 PL-2377.1 1083808 to 953 putative GTP-binding protein [Escherichia coli

1084899 K12] dbj |BAA36061.l| (D90756) Probable GTP- binding protein in pth 3' région (orf-3) .

[Escherichia coli] SEQ ID n~î550 pir| |B75371 ABC transporter, ATP-binding protein, ΞF-3 family - Deinococcus

Contig9 from radiodurans (strain RI) SEQ ID n° 6816 PL-2376.1 1085050 to 44% gb|AAF11195.l|AE002007_l (AE002007) ABC

1086747 transporter, ATP-binding protein, EF-3 family

[Deinococcus radiodurans] SEQ ID n~1549

Contig9 from SEQ ID n° 6817 PL-4221.1 1087244 to m No Hits found

Contig9 from SEQ ID n° 6818 PL-4220.1 1088131 to No Hits found

1088352 #N/A

TABLEAU II

Contig9 from SEQ ID n° 6819 PL-4219.1 1088349 to No Hits found

1088783 #N/A ref |NP_050653.l| S [Bacteriophage Mu]

Contig9 from sp | Q9T1V0 | VPS_BPMU TAIL FIBER PROTEIN (GPS) SEQ ID n° 6820 PL-2375.2 1088852 to 123 gb|AAF01127.l[AF083977_46 (AF083977) S

1090063

[Bacteriophage Mu] SEQ ID n-î.548

Contig9 from SEQ ID n° 6821 PL-3102.2 1090903 to No Hits found

1091709 SEQ ID n~2343 Contig9 from dbj |BAB06239.l| (AP001515) transposase related SEQ ID n° 6822 PL-3103.2 1091805 to 213 protein (20) [Bacillus halodurans]

1092830 SEQ ID n-2344 Contig9 from SEQ ID n° 6823 PL-3104.1 1093584 to No Hits found

1094426 SEQ ID n~2345 sp|P18355[YPFU_ECOLI HYPOTHETICAL 8.5 KDA

Contig9 from PROTEIN IN TRAD-TRAI INTERGENIC REGION SEQ ID n° 6824 PL-4217.1 1094623 to m 56% pir| |Q4ECTI hypothetical 8.5K protein (traD-tral

1094823 intergenic région) - Escherichia coli plasmid F #N/A pir| |T46999 hypothetical protein [imported] -

Yersinia pestis emb|CAA 1342.l| (AL031866)

Contig9 from

ORF19, len: 473 aa, similar to tyrosine SEQ ID n° 6825 PL-3105.1 1094861 to 783 aminotransferase, highly similar to E. coli

1096285

D90784_2, Fasta scores opt: 1842,

E(): 0 [Yersinia pestis] SEQ ID n~2346

TABLEAU II

pir| |T47273 cyanide insensitive terminal oxidase chain cioA [imported] - Pseudomonas aeruginosa pir| |G83155 cyanide insensitive terminal oxidase PA3930 [imported] -

Contig9 from

Pseudomonas aeruginosa (strain PAOl)

SEQ ID n° 6826 PL-3106.1 1096414 to P 85% emb |CAA71555.1] (Y10528) cyanide insensitive

1097751 terminal oxidase [Pseudomonas aeruginosa] gb|AAG07317.l| AE004810_9 (AE004810) cyanide insensitive terminal oxidase

[Pseudomonas aeruginosa] SEQ ID n~2347 pir] )T47274 cyanide insensitive terminal oxidase chain cioB [imported] - Pseudomonas aeruginosa pir| [F83155 cyanide insensitive terminal oxidase PA3929 [imported] -

Contig9 from

Pseudomonas aeruginosa (strain PAOl)

SEQ ID n° 6827 PL-3107.1 1097741 to 793 emb|CAA71556.l| (Y10528) cyanide insensitive

1098748 terminal oxidase [Pseudomonas aeruginosa] gb | AAG07316.1 [ AE004810_8 (AE004810) cyanide insensitive terminal oxidase

[Pseudomonas aeruginosa] SEQ ID n~2348 pir| |T47000 nitrate/nitrite sensor protein (EC

2.7.3.-) [similarity] - Yersinia pestis emb|CAA21343.l| (AL031866) ORF20, len:

Contig9 from 593 aa, probable nitrate/nitrite sensor

SEQ ID n° 6828 PL-3108.1 1098952 to 453 protein, highly similar to many, e g: E. coli

1100184 P10956,47.9% identity in 595 aa overlap Fasta scores: opt: 1801, E():0, and

PSNARXL_2 Pseudomonas aeruginosa narX, 33.1% identity in 596 aa ove> SEQ ID n~2349

TABLEAU II

sp|Q56646|VIUB_VIBCH VIBRIOBACTIN UTILIZATION

PROTEIN VIUB pir | |C82104 vibriobactin utilization protein ViuB VC2210 [imported] -

Contig9 from

Vibrio cholerae (group 01 strain SEQ ID n° 6829 PL-3109.1 1100323 to 503

N16961) gb|AAB86829.l| (AF030977) ViuB protein

1101156

[Vibrio cholerae] gb| AAF95354.l| (AE004293) vibriobactin utilization protein ViuB [Vibrio cholerae] SEQ ID n~2350 sp|P31544|PHOH_ECOLI PHOH PROTEIN (PHOSPHATE

STARVATION-INDUCIBLE PROTEIN PSIH) pir| |B47065 phosphate starvation-inducible protein psiH - Escherichia coli dbj |BAA01230.1 | (D10391) PhoH

Contig9 from protein [Escherichia coli] dbj |BAA35801. l| SEQ ID n° 6830 PL-3110.1 1101591 to m 863 (D90739) PhoH protein (phosphate starvation-

1102379 inducible protein PsiH) . [Escherichia coli] gb|AAC74105.l| (AE000204) PhoB-dépendent, ATP-binding pho regulon component; ay be helicase; induced by P starvation [Escherichia coli K12] SEQ ID n~2352

Contig9 from

SEQ ID n° 6831 PL-4214.1 1102707 to No Hits found

1102856 #N/A

Contig9 from dbj |BAB37244.1 | (AP002563) DNA-specific

SEQ ID n° 6832 PL-3111.3 1103031 to m 433 endonuclease I [Escherichia coli 0157 :H7]

1104029 #N/A

Contig9 from gb|AAG54576.l|AE005203_5 (AE005203) unknown

SEQ ID n° 6833 PL-3112.1 1104263 to m 143 protein from prophage CP-933H [Escherichia coli

1105549 0157 :H7] SEQ ID n~2354 sp|Q47427|TFAB_ECOLI TAIL FIBER ASSEMBLY PROTEIN

Contig9 from HOMOLOG pir|]S18684 gène T protein -

SEQ ID n° 6834 PL-3113.1 1105787 to m 55% Escherichia coli plasmid pl5B emb|CAA44047.l|

1106413

(X62121) T [Escherichia coli] SEQ ID n~2355

Contig9 from pir||S18689 Sc/SvP protein - Escherichia coli

SEQ ID n° 6835 PL-3114.1 1106435 to m 39% plasmid pl5B emb|CAA44052. l] (X62121) DNA

1107154 inversion product [Escherichia coli] SEQ ID n~2356

TABLEAU II

Contig9 from gb|AAG55257.l|AE005269_l (AE005269) SEQ ID n° 6836 PL-3115.1 1107537 to m 85% transmembrane water channel; aquaporin Z

1108232 [Escherichia coli 0157 :H7] SEQ ID n-2357 Contig9 from gb|AAG54942.l|AE005240_8 (AE005240) orf, SEQ ID n° 6837 PL-3754.1 1108724 to m 53% hypothetical protein [Escherichia coli θl57:H7]

1109161 SEQ ID n-2934 pir] |G82351 hypothetical protein VC0198

Contig9 from

[imported] - Vibrio cholerae (group 01 SEQ ID n° 6838 PL-4211.1 1109340 to m 53% strain N16961) gb] AAF93374.1 | (AE004110)

1109678 hypothetical protein [Vibrio cholerae] #N/A

Contig9 from gb|AAG54942.l|AE005240_8 (AΞ005240) orf, SEQ ID n° 6839 PL-3753.1 1109939 to m 63% hypothetical protein [Escherichia coli 0157 :H7]

1110367 SEQ ID n~2933 sp|P46120|YECF_ECOLI HYPOTHETICAL 8.2 KD PROTEIN

IN UVRY-SDIA INTERGENIC REGION pir| |H64954 yecF

Contig9 from protein - Escherichia coli dbj |BAA15735.l| SEQ ID n° 6840 PL-4210.1 1110727 to m 40% (D90832) ORF_ID:o341#12; similar to [SwissProt

1110951 Accession Number P46120] [Escherichia coli] gb]AAC74982.l| (AE000284) orf, hypothetical protein [Escherichia coli K12] #N/A

Contig9 from emb|CAA54809.l] (X95564) expA [Erwinia SEQ ID n° 6841 PL-3116.1 1111386 to p 853 carotovora]

1112051 SEQ ID n~2358 Contig9 from dbj |BAA15733.l| (D90832) Excinuclease ABC SEQ ID n° 6842 PL-3117.1 1112035 to p 903 subunit C. [Escherichia coli]

1113867 SEQ ID n~2359

TABLEAU II

sp | PO6978 | GSA_ECOLI CDP-DIACYLGLYCΞROL- -

GLYCEROL-3 -PHOSPHATE 3 -PHOSPHATIDYLTRANSFΞRASE

(PHOSPHATIDYLGLYCEROPHOSPHATE SYNTHASE) (PGP

SYNTHASE) pir||XNECPG CDPdiacylglycerol-- glycerol-3 -phosphate 3-phosphatidyltransferase

(EC 2.7.8.5) - Escherichia coli gb[AAA98754.1 |

(M12299) phosphatidylglycerophosphate synthase

Contig9 from

[Escherichia coli] gb | AAC74979.1 | (AE000284) SEQ ID n° 6843 PL-3752.1 1113925 to 803 phosphatidylglycerophosphate synthetase =

1114473

CDP-i, -diacyl-sn-glycero-3 -phosphate phosphatidyl transferase [Escherichia coli K12] gb|AAG56927.l|AE005414_4 (AE005414) phosphatidylglycerophosphate synthetase =

CDP-l, -diacyl-sn-glycero-3 -phosphate phosphatidyl transferase [Escherichia coli 0157 :H7] SEQ ID n~2932

Contig9 from gb|AAK02985.l| (AE006129) unknown [Pasteurella SEQ ID n° 6844 PL-4207.1 1114710 to p 313 multocida]

1114874 #N/A Contig9 from SEQ ID n° 6845 PL-4205.1 1115193 to p No Hits found

1115465 #N/A Contig9 from pir| |S18690 Sc/SvQ protein - Escherichia coli SEQ ID n° 6846 PL-3118.1 1115899 to m 513 plasmid pl5B emb| CAA44053.1 | (X62121) DNA

1116648 inversion product [Escherichia coli] SEQ ID n~2360 Contig9 from gb|AAG56009.l|AE005333_6 (AE005333) putative SEQ ID n° 6847 PL-3119.1 1116703 to m 223 tail fiber protein of prophage CP-933X

1118184 [Escherichia coli 0157 :H7] SEQ ID n~2361 Contig9 from pir| |S18690 Sc/SvQ protein - Escherichia coli SEQ ID n° 6848 PL-3120.1 1118978 to m 313 plasmid pl5B emb| CAA44053.1 | (X62121) DNA

1119895 inversion product [Escherichia coli] SEQ ID n~2363 Contig9 from gb|AAG56916.l|AE005413_10 (AE005413) putative SEQ ID n° 6849 PL-3751.1 1120502 to p 473 serine acetlyltransferase of prophage CP-933T

1121098 [Escherichia coli 0157 :H7] SEQ ID n~2931

TABLEAU II

Contig9 from gb|AAD37764.l|AF146532_4 (AF146532) putative SEQ ID n° 6850 PL-3121.1 1121134 to 523 glycosyltransferase [Klebsiella pneumoniae]

1122042 SEQ ID n-2364 pir| |C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 6851 PL-3122.1 1123092 to 413 gb]AAG04736.l|AE004564_5 (AE004564) probable

1123766 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~2365

Contig9 from SEQ ID n° 6852 PL-7020.1 1123939 to No Hits found

1124055 #N/A pir||C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 6853 PL-3123.2 1124515 to 43% gb|AAG04736.l|AE004564_5 (AE004564) probable

1125141 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~2366

Contig9 from dbj (BAA93674.l| (AB027193) Usp [Escherichia SEQ ID n° 6854 PL-4200.1 1125457 to 423 coli]

1125744 #N/A pir| |C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 6855 PL-3124.2 1126572 to 393 gb]AAG04736.l|AE004564_5 (AE004564) probable

1127264 transcriptional regulator [Pseudomonas aeruginosa] #N/A pir||C83477 probable transcription regulator

PA13 7 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 6856 PL-3125.2 1127320 to 40% gb|AAG04736.l|AE004564_5 (AE004564) probable

1127997 transcriptional regulator [Pseudomonas aeruginosa] #N/A

Contig9 from SEQ ID n° 6857 PL-4198.1 1128027 to No Hits found

1128173 #N/A

TABLEAU II

pir|]C83477 probable transcription regulator

PA13 7 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl)

_SEQ ID n° 6858 PL-3750.1 1128158_t^'o -413 gb|AAG04736.l|AE004564 3 (AΞ004564) probable

1128838 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~2930 pir||C83477 probable traiîscriptiôn regulator

PA13 7 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl)

SEQ ID n° 6859 PL-3749.1 1128865 to 39% gb|AAG04736.l|AE004564_5 (AE004564) probable

1129545 transcriptional- regulator [Pseudomonas aeruginosa] SEQ ID n~2928 pir| |C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl)

SEQ ID n° 6860 PL-4197.1 1129706 to 393 gb|AAG04736.l|AE004564_5 (AE004564) probable

1130386 transcriptional regulator [Pseudomonas aeruginosa] #N/A pir| |C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 6861 PL-3203.2 1130547 to 41% gb]AAG04736.l|AE004564_5 (AE004564) probable

1131227 transcriptional regulator [Pseudomonas aeruginosa] #N/A pir| |C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 6862 PL-3209.2 1131498 to gb|AAG04735.l|AE004564_5 (AE004564) probable

1132181 transcriptional regulator [Pseudomonas aeruginosa] #N/A pir||c83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl)

SEQ ID n° 6863 PL-3208.1 1132442 to 393 gb|AAG04736.l|AE004564_5 (AE004564) probable

1133122 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~2460

TABLEAU II

pir| |B82381 transcription regulator LuxR family

Contig9 from VCA1078 [imported] - Vibrio cholerae SEQ ID n° 6864 PL-3207.1 1133153 to p 42? (group 01 strain N16961) gb| AAF96971. l|

^" 1133833 (AE004433) transcriptional ^~ëgulator^~, LtixR^" family [Vibrio cholerae] SEQ ID n~2459 pir| ]B82381 transcription regulator LuxR family

- - - - - - -- Contig9 from — ^~VCA1O78 [imported] - Vibrio = chôTêrae

SEQ ID n° 6865 PL-3206.1 1133863 to p 38% (group 01 strain N16961) gb| AAF96971. l|

1134543 (AE004433) transcriptional regulator, LuxR family [Vibrio cholerae] SEQ ID n~245É pir||C83477 probable transcription regulator

PA13 7 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 6866 PL-3205.1 1134574 to p 393 gb|AAG04736.l|AE004564_5 (AE004564) probable

1135254 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~2457 pir| |B82381 transcription regulator LuxR family

Contig9 from VCA1078 [imported] - Vibrio cholerae SEQ ID n° 6867 PL-3204.2 1135284 to 39% (group 01 strain N16961) gb| AAF96971. l|

1135907 (AEO04433) transcriptional regulator, LuxR family [Vibrio cholerae] #N/A pir||C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 6868 PL-4195.1 1136257 to 41% gb|AAG04736.l|AE004564_5 (AE004564) probable

1136937 transcriptional regulator [Pseudomonas aeruginosa] #N/A pir]|C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 6869 PL-2152.2 1136965 to p 42% gb|AAG04736.l[AE004564_5 (AE004564) probable

1137636 transcriptional regulator [Pseudomonas aeruginosa] #N/A

TABLEAU II

pιr| C83 77 probable transcription regulator PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl)

SEQ ID n° 6870_PL=-2153- - 1137784 to p 43? gb|AAG04736.1|AE004564_5 (AE004564) probable- 1138479 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~î305 sp | P4 545 | YHFS_ECOLI HYPOTHETICAL 38 , KD^~≈' PROTEIN IN CYSG-TRPS INTERGENIC REGION (F361) pir| |C65132 hypothetical 38.6 kD protein m cysG

Contig9 from trpS intergenic région - Escherichia SEQ ID n° 6871_PL-2154.1 1138766 to m 73^!

— coli (strain K-12) gb| AAA58173.1 | (U18997)—

1139902

ORF_f361 [Escherichia coli] gb| AAC76401.1 |

(AE000413) orf, hypothetical protein

[Escherichia coli K12] SEQ ID n~2306

Contig9 from dbj |BAB04308.1 | (AP001509) BH0589-unknown SEQ ID n° 6872 PL-2155.1 1139950 to m 64% conserved protein m others [Bacillus

1141284 halodurans] SEQ ID n~î307 Contig9 from dbj |BAB04307.1] (AP001509) BH0588-unknown SEQ ID n° 6873 PL-4194.1 1141322 to m 65% conserved protein in others [Bacillus

1141681 halodurans] #N/A pdb|lBF6|B Chain B, Phosphotriesterase Homology

Contig9 from

Protein From Escherichia Coli pdb|lBF6|A Chain SEQ ID n° 6874 PL-2156.1 1141693 to m 71%

A, Phosphotriesterase Homology Protein From

1142583

Escherichia Coli SEQ ID n~1308 sp|P45550|YHFX_ECOLI HYPOTHETICAL 44.3 KD

PROTEIN IN CYSG-TRPS INTERGENIC REGION (F387) pir| |H65132 hypothetical 44.3 kD protein in cysG

Contig9 from trpS intergenic région - Escherichia SEQ ID n° 6875 PL-2157.1 1142627 to m 733 coli (strain K-12) gb| AA58178.1 | (U18997)

1143805

ORF_f387 [Escherichia coli] gb] AC76406. l|

(AEO00413) orf, hypothetical protein

[Escherichia coli K12] SEQ ID n-2.309

Co SEQ ID n° 6876 PL-4193.1 1

TABLEAU II

Contig9 from sp|P45552|YHFZ_ECOLI HYPOTHETICAL 30.3 KD

SEQ ID n° 6877 PL-2158.1 1144302 to 723 PROTEIN IN CYSG-TRPS INTERGENIC REGION

1145207 SEQ ID n~î310 sp|P20966|PTFB_ECOLI PTS SYSTEM, FRUCTOSE- SPECIFIC IIBC COMPONENT (EIIBC-FRU) (FRUCTOSE-PERMEASE IIBC COMPONENT)

(PHOSPHOTRANSFERASE ENZYME II, BC

COMPONENT) (ΞII-FRU) pir| |A34962 phosphotransferase system enzyme II (EC

Contig9 from

2.7.1.69), fructose-specific -

SEQ ID n° 6878 PL-2159.1 1145360 to 81%

Escherichia coli— gb (AAA60524.1 | (U00007)

1147030 fructose-specific IIBC component [Escherichia coli] gb|AAA62624.l| (M23196) enzyme II-fru

[Escherichia coli] gb|AAC75228.1 | (AE000306)

PTS system, fructose-specific transport protein

[Escherichia coli K12] prf | |2014253BN fruA gène

[Escherichia coli] SEQ ID n-2.311

TABLEAU II

sp|P24217|PTFA_ECOLI PTS SYSTEM, FRUCTOSE- SPECIFIC IIA/FPR COMPONENT (EIIA-FRU) (FRUCTOSE-PERMEASE IIA/FPR COMPONENT)

(PHOSPHOTRANSFERASE ENZYME II, A/FPR COMPONENT)

(PHOSPHOTRANSFERASE FPR PROTEIN) (PSEUDO-HPR)

(EIII-FRU) (FRUCTOSE PTS DIPHOSPHORYL

TRANSFER PROTEIN) pir| Ï53564 phosphotransferase system enzyme II (EC

2.7.1.69) - Escherichia coli

Contig9 from gb|AAA60534.l| (U00007) fructose-specific

SEQ„ID n° 6879 PL-2160.1 1147100 to 743

IIA/FPR component [EscherichïaTcoli]

1148227 gb|AAB31084.l| (S72443) DTP,

FruB≈phosphoenolpyruvate : sugar phosphotransferase system diphosphoryl transfer protein [Escherichia coli,

Peptide, 376 aa] gb|AAC75230.l| (AE000306) PTS system, fructose-specific IIA/fpr. component

[Escherichia coli K12] prf | |2014253BV phosphotransferase FPr protein [Escherichia coli] SEQ ID n~î313

Contig9 from pir||S53063 FimB protein - Escherichia coli SEQ ID n° 6880 PL-2161.1 1148802 to 663 emb|CAA85725.l| (Z37500) FimB protein

1149422 [Escherichia coli] SEQ ID n~3L314 sp|P45545|YHFS_ECOLI HYPOTHETICAL 38.6 KD

PROTEIN IN CYSG-TRPS INTERGENIC REGION

(F361) pir||c65132 hypothetical 38.6 kD protein

Contig9 from in cysG-trpS intergenic région - SEQ ID n° 6881 PL-4191.1 1149422 to m 56%

Escherichia coli (strain K-12) gb|AAA58173.1 |

1149616

(U18997) ORF_f361 [Escherichia coli] gb(AAC76401.l[ (AE000413) orf, hypothetical protein [Escherichia coli K12] #N/A

TABLEAU II

pir||D70180 phosphotransferase System enzyme II

(EC 2.7.1.69), glucose-specific,

Contig9 from factor II - Lyme disease spirochete

SEQ ID n° 6882 PL-2162_.1 115.03_9.9_ to 563 gb | AAC66998T | (AE001166) PTS System, glucose-

1151940 specific IIBC component (ptsG) [Borrelia burgdorferi] SEQ ID n~ï315 sp | O0W0i lîŒIF USMR MALTOSE-6 ' -PHOSPHATE

Contig9 from GLUCOSIDASE (6-PHOSPHO-ALPHA-D-GLUCOSIDASE) SEQ ID n° 6883 PL-2163.1 1151954 to 653 gb|AAB63015.l| (U81185) MalH [Fusobacterium

1153312 mortiferum] SEQ ID n~ï316 gb|AADl-1507.l| (U60828) unknown [Lactococcus

Contig9 from lactis] gb|AAK06083.l|AE006429_l (AE006429) SEQ ID n° 6884 PL-2164.1 1153569 to 423 transcription regulator [Lactococcus lactis

1154348 subsp. lactis] SEQ ID n~î317

Contig9 from SEQ ID n° 6885 PL-4188.1 1155267 to No Hits found

1155404 #N/A pir[|B82381 transcription regulator LuxR family

Contig9 from VCA1078 [imported] - Vibrio cholerae SEQ ID n» 6886 PL-3980.1 1155444 to 443 (group 01 strain N16961) gb|AAF96971.l]

1155893 (AE004433) transcriptional regulator, LuxR family [Vibrio cholerae] SEQ ID n~3139 pir||C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 6887 PL-2165.1 1156074 to 433 gb|AAG04736.l|AE004564_5 (AE004564) probable

1156769 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n-î.318 pir| |T37066 probable intégral membrane protein -

Contig9 from

Streptomyces coelicolor emb|CAB52363.1 | SEQ ID n^» 6888 PL-2166.1 1157089 to m 683

(AL109747) putative intégral membrane protein

1158345

[Streptomyces coelicolor A3 (2)] SEQ ID n~î319

Contig9 from dbj |BAB03941.1] (AP001507) BH022 ~unknθWn SEQ ID n° 6889 PL-4187.1 1158359 to 503 conserved protein [Bacillus halodurans]

1158664 #N/A

TABLEAU II

Contig9 from dbj |BAB03939.l| (AP001507) BH0220-unknown SEQ ID n° 6890 PL-3979.1 1158676 to m 59% conserved protein [Bacillus halodurans]

1159119 SEQ ID n~3137 Contig9 from gb|AAK02875.l| (AΞ006117) unknown [Pasteurella SEQ ID n° 6891 PL-2167.1 1159358 to 483 multocida]

1160401 SEQ ID n-5.320 Contig9 from emb|CAB71827.l| (AL138662) hypothetical protein SEQ ID n° 6892 PL-3978.1 1160460 to m 463 SC8E4A.22 [Streptomyces coelicolor

1160924 A3 (2)] SEQ ID n~3136 pir| |C83418 hypothetical protein PA1817

Contig9 frôtfT [imported] - PslËueftomorias aeruginosa SEQ ID n° 6893 PL-4186.1 1161131 to 373 (strain PAOl) gb|AAG05206.l| AE004608_5

1161532 (AE004608) hypothetical protein [Pseudomonas aeruginosa] #N/A pir||D83102 xenobiotic reductase PA4356

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 6894 PL-2168.1 1161714 to 763 (strain PAOl) gb|AAG07744.l|AE004851_12

1162769 (AE004851) xenobiotic reductase [Pseudomonas aeruginosa] SEQ ID n~ï321

Contig9 from SEQ ID n° 6895 PL-3977.1 1163153 to m No Hits found

1163482 SEQ ID n~3135 Contig9 from SEQ ID n° 6896 PL-4185.1 1163451 to m No Hits found

1163687 #N/A ref |NP_047871.1 | murine toxin [Yersinia pestis]

Contig9 from pir] |T14986 toxin protein - Yersinia pestis SEQ ID n° 6897 PL-2169.1 1164203 to 72% plasmid pMTl gb|AAC82729.l| (AF074611) murine

1165924 toxin [Yersinia pestis] SEQ ID n-S.322

TABLEAU II

sp|P00926|SDHD_ECOLI D-SERINE DEHYDRATASE (D-

SERINE DEAMINASE) pir] | DWECS D-serine dehydratase (EC 4.2.1.14) - Escherichia coli

Contig9 from gb|AAC75425.l[ (AE000324) D-serine dehydratase SEQ ID n° 6898 PL-2170.1 1166142 to m 76% (deaminase) [Escherichia coli K12]

1167473 dbj [BAA16229.1 | (D90866) D-serine dehydratase ^~~: (EC^~~4.2.1.14) [Escherichia coli] dbj |BAA16237.l| (D90867) D-serine dehydratase

(EC 4.2.1.14) [Escherichia coli] SEQ ID n-î.324 sp|P08555|DSDX_ECOLI DSDX PERMEASE pir||S54140

D-serine permease - Escherichia coli - - emb| CAA60138.1 [ (X86379) D-serine permease

[Escherichia coli] emb| CAA62932.1 | (X91821)

Contig9 from dsdX [Escherichia coli] gb| AAC75424.1 |

SEQ ID n° 6899 PL-2171.1 1168158 to m 89%

(AΞ000324) transport system permease (serine?)

1169495

[Escherichia coli K12] dbj |BAA16225.l| (D90866) DSDX PERMEASE .

[Escherichia coli] dbj |BAA16233.1 | (D90867)

DSDX PERMEASE. [Escherichia coli] SEQ ID n~_.325 sp|P46068|DSDC_ECOLI D-SERINE DEAMINASE

ACTIVATOR pir| |A65010 D-serine deaminase activator - Escherichia coli (strain K-12)

Contig9 from gb|AAC75423.l| (AΞ000324) D-serine dehydratase

SEQ ID n° 6900 PL-2172.1 1169737 to 73? (deaminase) transcriptional activator

1170675 [Escherichia coli K12] dbj |BAA16224. l| (D90866)

D-SERINE DEAMINASE ACTIVATOR. [Escherichia coli] dbj |BAA16232.l| (D90867) D-SERINE DEAMINASE

ACTIVATOR. [Escherichia coli] SEQ ID n-î.326

Contig9 from gb|AAG58105.l|AE005527_8 (AE005527) putative

SEQ ID n° 6901 PL-3975.1 1170985 to 48% PagC-like membrane protein [Escherichia coli

1171533 0157-.H7] SEQ ID n~3134

Contig9 from gb|AAG54576.l|AE005203_5 (AE005203) unknown

SEQ ID n° 6902 PL-2173.1 1172158 to 17% protein from prophage CP-933H [Escherichia

1173003 coli 0157 :H7] SEQ ID n-î.327

TABLEAU II

sp | P39312 | CYCA_ECOLI D-SERINE/D-ALANINE/GLYCINE

TRANSPORTER pir||S56433 D-serine/D- alanine/glycine transporter - Escherichia coli

Contig9 from gb|AAA97104.1] (U14003) ORF_o470 [Escherichia SEQ ID n° 6903 PL-2174.1 1173716 to p 813 coli] gb]AAC77165.l| (AE000492) transport of D-

1175122 alanine, D-serine, and glycine

[Escherichia^"côTrκi2] ^~-gb| AAG59406.l| AE005653 7

(AE005653) transport of D-alanine, D-serine, and glycine [Escherichia coli 0157 :H7] SEQ ID n-î.328

Sp|P30849|WRBA_ECOLI TRP REPRESSOR BINDING

PROTEIN ^~p r^"|^~|B64842 trp repressor-binding protein - Escherichia coli gb | AAC74089.1 |

(AE000202) trp repressor binding protein,-

Contig9 from affects association of trp repressor SEQ ID n° 6904 PL-2175.1 1175502 to p 773 and operator [Escherichia coli K12]

1176101 dbj |BAA35771.l| (D90737) Trp repressor binding protein [Escherichia coli] dbj |BAA35781.1 |

(D90738) Trp repressor binding protein

[Escherichia coli] SEQ ID n~î329 ref |NP_052901.l| transposase for Tn21 [Plasmid

Contig9 from R100] dbj |BAA78805.l| (AP000342) transposase SEQ ID n° 6905 PL-4180.2 1176159 to m 30% for Tn21 [Plasmid R100]

1176440 gb|AAG14402.l|AF188331_l (AF188331) putative transposase [Shigella flexneri] #N/A

Contig9 from sp| 04218 ]REST_CHICK RESTIN (CYTOPLASMIC LINKER SEQ ID n° 6906 PL-2176.3 1176730 to p 40% PROTEIN-170) (CLIP-170) gb | AAC6034 .1 |

1177968 (AF014012) restin [Gallus gallus] #N/A pir| |T29999 hypothetical protein ZC8.4 -

Contig9 from Caenorhabditis elegans gb] AAB52624. l] (U64862) SEQ ID n° 6907 PL-4179.2 1178011 to p 40% strong similarity to Onchocerca volvulus major

1179039 antigen (SP:P212249) [Caenorhabditis elegans] #N/A

Contig9 from gb|AAA25324.l| (L34345) xylitol dehydrogenase SEQ ID n° 6908 PL-2178.1 1179680 to p 82% [Morganella morganii]

1180708 SEQ ID n-ï.332

TABLEAU II

Contig9 from gb]AAK03455.l| (AE006175) unknown [Pasteurella SEQ ID n° 6909 PL-2179.1 1180712 to 663 multocida]

1182223 SEQ ID n-î.333 sp|P07117|PUTP_ECOLI SODIUM/PROLINE SYMPORTER

(PROLINE PERMEASE) pir| | JGΞCPP sodium/proline symporter - Escherichia coli emb|CAA29143.l|

Contig9 from (X05653) putP proline carrier -(AS. 1-5O2)^" SEQ ID n° 6910 PL-2180.1 1182302 to m 80% [Escherichia coli] dbj |BAA35793.l| (D90738)

1183786 Proline carrier protein [Escherichia coli] gb|AAC74100.l| (AE000203) major sodium/proline symporter [Escherichia coli KI2T] prf | 11404369A

Pro carrier protein [Escherichia coli] SEQ ID n-£335

Contig9 from gb|AAG55630.l|AE005301_2 (AE005301) proline SEQ ID n° 6911 PL-2181.1 1184273 to p 86% dehydrogenase, P5C dehydrogenase [Escherichia

1188253 coli 0157:H7] SEQ ID n-î.336 Contig9 from emb|CAB46361.l| (AJ131736) FliZ protein SEQ ID n° 6912 PL-3974.1 1188330 to m 89% [Xenorhabdus nematophilus]

1188842 SEQ ID n~3133 Contig9 from emb|CAB46360.1] (AJ131736) FliA, sigma 28 SEQ ID n° 6913 PL-2182.1 1188895 to m 88% [Xenorhabdus nematophilus]

1189617 SEQ ID n-î.337 Contig9 from sp|P13713|FLIC_SERMA FLAGELLIN pir| ]JU0056 SEQ ID n° 6914 PL-2183.1 1189864 to m 74% flagellin - Serratia marcescens gb|AAA26556.1 |

1190931 (M27219) flagellin [Serratia marcescens] SEQ ID n-ï.338 pir]|JC5755 hook-associated protein 2 -

Contig9 from

Xenorhabdus nematophilus emb| CAA62510.1 | SEQ ID n° 6915 PL-2184.1 1191206 to p 83%

(X91047) hook-associated protein 2 [Xenorhabdus

1192627 nematophilus] SEQ ID n-î.339

Contig9 from sp| 26609 |FLIS_SALTY FLAGELLAR PROTEIN FLIS SEQ ID n° 6916 PL-4175.1 1192640 to p 70% gb|AAA27077.l| (M85241) flagellar protein

1193050 [Salmonella typhimurium] #N/A

TABLEAU II

sp|P26610|FLIT_ECOLI FLAGELLAR PROTEIN FLIT pir|]C64956 flagellar protein fliT - Escherichi coli_ gb|AAA237^92.l| (M85240) flagellar proteii

[Escherichia coli] dbj |BAA15754.l| (D90833)

Flagellar protein FliT. [Escherichia coli]

Contig9 from gb|AAC74993.l| (AE000285) flagellar

SEQ ID n° 6917 PL-3-9-7-3-.-1- 1-1-93050 to 503 biosynthesis; repressor of class 3a and 3b

1193427 opérons (RflA activity) [Escherichia coli K12] gb|AAG56941.l|AE005415_6 (AE005415) flagellar biosynthesis; repressor of class 3a and 3b ^~~operons (RflA activity) [Escherichia coli 0157:H7] SEQ ID n~3132

Contig9 from

SEQ ID n° 6918 PL-2185.1 1193829 to No Hits found

1194641 SEQ ID n-1340 sp|P25797|FLIE_ECOLI FLAGELLAR HOOK-BASAL BODY COMPLEX PROTEIN FLIΞ pir] |A42376 flagellar hook- basal body complex protein fliE - Escherichia coli gb] AAA23800.l| (M84992) flagellar protein

[Escherichia coli] dbj |BAA15760. l| (D90833)

Flagellar hook-basal body 11K protein FliE

[Escherichia coli] dbj [BAA15762. l|

Contig9 from

(D90834) Flagellar hook-basal body 11K protein SEQ ID n^» 6919 PL-4174.1 1195239 to m 69%

FliE [Escherichia coli]

1195550 gb|AAC75004.l| (AE000286) flagellar biosynthesis; basal-body component, possibly at (MS-ring) -rod junction [Escherichia coli K12] gb|AAG56952.l|AE005416_6 (AΞ005416) flagellar biosynthesis; basal-body component, possibly at (MS-ring) -rod junction [Escherichia coli

0157 :H7] #N/A

TABLEAU II

sp|P25798|FLIF_EC0LI FLAGELLAR M-RING PROTEIN pir| |G64957 flagellar basal-body M-ring protein

Escherichia coli dbj |BAA15763.l| (D90834)

Contig9- fi-rom-

Flagellar M-ring protein (fragments) .

SEQ ID n° 6920 PL-2186.1 1195836 to 763

[Escherichia coli] gb| AAC75005. l| (AE000286) 1197539 flagellar biosynthesis; basal-body MS (membrane and suprâmembrane) -ring and collar protein [Escherichia coli K12] SEQ ID n-2.341 sp|P15933 (FLIG_SALTY FLAGELLAR MOTOR SWITCH

Contig9 from PROTEIN FLIG pir] |A30929 flagellar motor switch SEQ ID n° 6921 PL-2187.1 1197536-to p 913 protein fliG ^-Salmonella typhimurium

1198528 gb|AAA27097.l| (M24462) fliG flagellar switch protein [Salmonella typhimurium] SEQ ID n~î342

Contig9 from gb|AAG56955.l|AE005416_9 (AE005416) flagellar SEQ ID n° 6922 PL-2188.1 1198521 to p 683 biosynthesis,- export of flagellar proteins?

1199225 [Escherichia coli 0157 :H7] SEQ ID n-3.343 Contig9 from gb|AAG56956.l|AE005416_10 (AE005416) flagellum- SEQ ID n° 6923 PL-2189.1 1199225 to p 883 specific ATP synthase [Escherichia coli

1200589 0157 :H7] SEQ ID n-2.344 Contig9 from gb|AAG56957.l|AE005416_ll (AE005416) flagellar SEQ ID n° 6924 PL-3972.1 1200632 to p 613 fliJ protein [Escherichia coli 0157 :H7]

1201075 SEQ ID n~3131 sp|P52614|FLIK_ECOLI FLAGELLAR HOOK-LENGTH CONTROL PROTEIN pir| |D64958 flagellar hook- length control protein fliK - Escherichia coli

Contig9 from gb|AAB06632.l| (L43491) fliK gène product SEQ ID n° 6925 PL-2190.1 1201075 to p 40? [Escherichia coli] dbj |BAA15768. l| (D90834)

1202403 Flagellar hook-length control protein.

[Escherichia coli] gb| AAC75010.1 | (AE000286) flagellar hook-length control protein

[Escherichia coli K12] SEQ ID n-2.346 sp|P26417|FLIL_SALTY FLAGELLAR FLIL PROTEIN

Contig9 from pir| |B30929 flagellar protein fliL - Salmonella SEQ ID n° 6926 PL-3971.1 1202577 to p 573 typhimurium gb| AA27103.l| (M24463) fliL

1203053 flagellar protein [Salmonella typhimurium] SEQ ID n~3130

TABLEAU II

sp|P06974]FLIM_ECOLI FLAGELLAR MOTOR SWITCH PROTEIN FLIM pir| |XMECF2 flagellar motor switch protein fliM - Escherichia coli gb|AAA23786. l|

(M12784) FlaAII protein [Escherichia coli]

Contig9 from dbj |BAA15770.l] (D90834) Flagellar motor switch SEQ ID n° 6927 PL-2191.1 1203059 to protein FliM. [Escherichia coli] gb| AC7501 .1 |

1204063

^TÂË000286) flagellar biosynthesis, component of- motor switch and energizing, enabling rotation and determining its direction [Escherichia coli K12] SEQ ID n-î347 sp|P26419|FLIN_SALTY FLAGELLAR MOTOR-SWITCH

Contig9 from PROTEIN FLIN pir| |D30929 flagellar motor switch SEQ ID n° 6928 PL-4171.1 1204056 to 77% protein fliN - Salmonella typhimurium

1204475 gb|AAA27105.l| (M24463) fliN flagellar switch protein [Salmonella typhimurium] #N/A sp|P34199|MOPB_ΞRWCA MOPB PROTEIN pir||S35275

Contig9 from probable flagellar biosynthesis protein mopB - SEQ ID n° 6929 PL-3970.1 1204582 to 533 Erwinia carotovora subsp. atroseptica

1204929 emb|CAA51475.l| (X72969) mopB [Erwinia carotovora] SEQ ID n~3129 sp|P33133|FLIP_ECOLI FLAGELLAR BIOSYNTHETIC

PROTEIN FLIP pir| |B36869 probable export protein fliP precursor - Escherichia coli gb|AAC36859.l| (L22182) flagellar protein

[Escherichia coli] dbj |BAA15773.l| (D90834)

Contig9 from

Flagellar biosynthetic protein FliP.

SEQ ID n° 6930 PL-2192.1 1204961 to 80? [Escherichia coli] dbj |BAA15779.l| (D90835)

1205695

Flagellar biosynthetic protein FliP.

[Escherichia coli] gb|AAC75015.1 | (AE000287) flagellar biosynthesis [Escherichia coli K12] gb|AAG56963.l|AE005417_5 (AE005417) flagellar biosynthesis [Escherichia coli 0157 :H7] SEQ ID n~2348

TABLEAU II

sp|P5470l|FLIQ_SALTY FLAGELLAR BIOSYNTHETIC

Contig9 from PROTEIN FLIQ pir_| S78699 probable export SEQ ID n° 6931 PL-4170.1 1205716 to 853 protein fliQ - Salmonella typhimurium

1205985 gb|AAB81320.l] (L49021) fliQ [Salmonella typhimurium] #N/A sp|P34202|FLIR_ERWCA FLAGELLAR BIOSYNTHETIC

PROTEIN^" FLIR-^"(FLAGELLAR BIOSYNTHETIC PROTEIN ^~

Contig9 from

MOPE) pir||S42698 probable export protein mopE - SEQ ID n^» 6932 PL-2193.1 1205988 to p 763

Erwinia carotovora subsp. atroseptica

1206770 emb[CAA51478.l| (X72969) mopE [Erwinia carotovora] SEQ D n~_.3^~4^~9

Contig9 from ref |NP_071283.l| Predicted DNA methylase SEQ ID n° 6933 PL-2194.1 1207194 to m 403 containing a Zn-ribbon module

1209281 [Archaeoglobus fulgidus] SEQ ID n-3.350 Contig9 from SEQ ID n° 6934 PL-2195.1 1209382 to m No Hits found

1210125 SEQ ID n~î351 Contig9 from ref |NP_052450.l| yacA [Plasmid Collb-P9] SEQ ID n° 6935 PL-4168.1 1210587 to p 533 dbj |BAA75089.l| (AB021078) yacA [Plasmid Collb-

1210871 P9] #N/A sp|Q58503|YB03_METJA HYPOTHETICAL PROTEIN MJ1103

Contig9 from pir| |F64437 hypothetical protein MJ1103 - SEQ ID n° 6936 PL-4167.1 1211353 to p 383 Methanococcus jannaschii gb|AAB99106.1 |

1211613 (U67553) conserved hypothetical protein

[Methanococcus jannaschii] #N/A pir| |G82793 hypothetical protein XF0534

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 6937 PL-4166.1 1211690 to 443 (strain 9a5c) gb| AAF83344.l|AE003901 7

1212064 (AE003901) hypothetical protein [Xylella fastidiosa] #N/A pir| ]D82498 conserved hypothetical protein

Contig9 from VCA0105 [imported] - Vibrio cholerae SEQ ID n° 6938 PL-4165.1 1212311 to m 483 (group 01 strain N16961) gb| AF96019.1 |

1212580 (AE004353) conserved hypothetical protein

[Vibrio cholerae] #N/A

TABLEAU II

Contig9 from

SEQ ID n° 6939 PL-2196.1 1212707 to m No Hits, found

1213726 SEQ ID n~ï352

Contig9 from

SEQ ID n° 6940 PL-2197.1 1213734 to m No Hits found

1215335 SEQ ID n~£353

Contig9 from

SEQ ID n° 6941 PL-2198.1 1215356 to m No Hits found

1216285 SEQ ID n-î.354

Contig9 from gb|AAC62387.l| (AF0445061 VgrG protein

-SEQ ID n° 6942 PL-2199.1 1216282 to m 503 [Escherichia coli]

1218249 SEQ ID n-î.355 sp|P16326|FLGL_SALTY FLAGELLAR HOOK-ASSOCIATED

Contig9 from PROTEIN 3 (HAP3) (HOOK-FILAMENT JUNCTION SEQ ID n° 6943 PL-2200.1 1218862 to 72% PROTEIN) pir||si0362 hook-associated protein 3

1219827 Salmonella typhimurium emb|CAA36028.l| (X51739) HAP3 [Salmonella typhimurium] SEQ ID n-î.358 sp|P33235 |FLGK_ECOLI FLAGELLAR HOOK-ASSOCIATED PROTEIN 1 (HAP1) pir||G64851 flagellar hook- associated protein 1 - Escherichia coli

Contig9 from dbj |BAA35891.l| (D90744) Flagellar hook- SEQ ID n° 6944 PL-2201.1 1219902 to m 633 associated protein 1 (hapl) . [Escherichia

1221551 coli] gb|AAC74166.l| (AE000209) flagellar biosynthesis, hook-filament junction protein 1 [Escherichia coli K12] SEQ ID n~∑359 sp|P1593l|FLGJ_SALTY FLAGELLAR PROTEIN FLGJ

Contig9 from pir|]C30930 flagellar protein flgJ - Salmonella SEQ ID n° 6945 PL-2202.1 1221678 to 693 typhimurium gb| AAA27070. l| (M24466) flgJ

1222622 flagellar protein [Salmonella typhimurium] SEQ ID n-S.360

TABLEAU II

sp]P7594l|FLGI_ECOLI FLAGELLAR P-RING PROTEIN

PRECURSOR_ pir| |E64851 flagellar basai body P- ring protein precursor - Escherichia coli jContig9 from gb| AAC74164.l| (AE000208) homolog of Salmonella

SEQ ID n° 6946 PL-2203.1 1222619 to 833

P-ring of flagella basai body 1223728 [Escherichia coli K12] dbj |BAA35889.l| (D90744) ^~Flagellar basai body P-ring protein precursol:

[Escherichia coli] SEQ ID n~î361

Contig9 from dbj BAA35888.1] (D90744) Flagellar basai body L-

SEQ ID n° 6947 PL-2204.1 1223741 to 703 ring protein precursor [Escherichia

1224493 - coli] ^~ -SEQ ID n~_.362 sp|P16439|FLGG_SALTY FLAGELLAR BASAL-BODY ROD

PROTEIN FLGG (DISTAL ROD PROTEIN) pir| |XMEBFG

Contig9 from flagellar basai body rod protein flgG -

SEQ ID n° 6948 PL-2205.1 1224568 to 863

Salmonella typhimurium emb | CAA36314.1 ] (X52094)

1225350 flgG protein product (AA 1-260) [Salmonella typhimurium] SEQ ID n-î.363 sp|P16323|FLGF_SALTY FLAGELLAR BASAL-BODY ROD

PROTEIN FLGF (PUTATIVE PROXIMAL ROD

Contig9 from PROTEIN) pir| |XMEBFF flagellar basai body rod

SEQ ID n° 6949 PL-2206.1 1225374 to m 763 protein flgF - Salmonella typhimurium

1226129 emb(CAA36313.l| (X52094) flgF protein product

(AA 1-251) [Salmonella typhimurium] SEQ ID n- 2.364 sp]P16322 |FLGE_SALTY FLAGELLAR HOOK PROTEIN FLGE

Contig9 from pir| |S10365 flagellar hook protein flgE - SEQ ID n° 6950 PL-2208.1 1226148 to 723 Salmonella typhimurium emb | CAA36022.1 | (X51737)

1227362 flgE protein (AA 1-403) [Salmonella typhimurium] SEQ ID n~î365 sp|P1632l|FLGD_SALTY BASAL-BODY ROD MODIFICATION

Contig9 from PROTEIN FLGD pir| |S47641 flagellar hook

SEQ ID n° 6951 PL-2209.2 1227390 to 743 formation protein flgD - Salmonella typhimurium

1228085 dbj |BAA04982.l| (D25293) flagella [Salmonella typhimurium] #N/A

TABLEAU II

sp|Q56894]FLGC_YEREN FLAGELLAR BASAL-BODY ROD

Contig9 from PROTEIN FLGC pir | | S54220 flagellar basai body SEQ ID n° 6952 PL-4162.2 1228098 to m 853 rod protein flgC - Yersinia enterocolitica

1228502 emb | CAA88193 Ï1 (Z48169) fïgC [Yersinia enterocolitica] ftN/A

Contig9 from

SEQ ID n° 6953 PL-3969.2 12285 CT8^~Εθ m 623 gb|AAC45657.l| (U822Î4 FlgB^'-[Proteus mirabilis]

1228921 #N/A

Contig9 from

SEQ ID n° 6954 PL-2210.1 1229170 to 62% gb|AAC45658.l| (U82214) FlgA [Proteus mirabilis]

1229829 SEQ ID n~î368-

Contig9 from sp|P96974|FLGM_PROMI NEGATIVE REGULATOR OF

SEQ ID n° 6955 PL-4161.1 1229954 to 67% FLAGELLIN SYNTHESIS (ANTI-SIGMA-28 FACTOR)

1230256 gb|AAC45659.l| (U82214) FlgM [Proteus mirabilis] #N/A

Contig9 from sp|P96975|FLGN_PROMI FLAGELLA SYNTHESIS PROTEIN

SEQ ID n° 6956 PL-3968.1 1230268 to 66% FLGN gb|AAC45660.l| (U82214) FlgN [Proteus

1230708 _ mirabilis] SEQ ID n~3126 pir|]A45592 liver stage antigen LSA-1 - malaria

Contig9 from parasite (Plasmodium falciparum)

SEQ ID n° 6957 PL-2211.1 1231156 to 28% emb |CAA39663.l| (X56203) liver stage antigen

1232184

[Plasmodium falciparum] SEQ ID n-î.369

Contig9 from

SEQ ID n° 6958 PL-2212.1 1232321 to m No Hits found

1233796 SEQ ID n-î.370

Contig9 from

SEQ ID n° 6959 PL-4159.1 1233842 to m No Hits found

1234006 #N/A

Contig9 from

SEQ ID n° 6960 PL-2213.1 1234876 to m No Hits found

1236348 SEQ ID n~ï371

Contig9 from

SEQ ID n° 6961 PL-2214.1 1236407 to m No Hits found

1237870 SEQ ID n-î.372

Contig9 from

SEQ ID n° 6962 PL-3941.2 1237919 to m No Hits found

1239421 #N/A

TABLEAU II

Contig9 from SEQ ID n° 6963 PL-2216.2 1239484 to No Hits found

1240947 SEQ ID n-î.374 Contig9 from SEQ ID n° 6964 PL-2215.2 1240995 to No Hits found

1242498 SEQ ID n~î373 sp]P26007|ITA6_CHICK INTEGRIN ALPHA-e-pRECURSOR

Contig9 from

(VLA-6) pir| |A38457 integrin alpha-6 «chain SEQ ID n° 6965 PL-3150.1 1242561 to m 143 precursor - chicken emb(CAA39909. l| (X56559)

1244075 integrin alpha 6 subunit [Gallus gallus] SEQ ID n~2396 - Contig9 from

SEQ ID n° 6966 PL-3151.1 1244134 to m No Hits found

1245627 SEQ ID n~2397 Contig9 from SEQ ID n° 6967 PL-4155.1 1245677 to m No Hits found

1246078 #N/A Contig9 from SEQ ID n° 6968 PL-3152.1 1246097 to m No Hits found

1247668 SEQ ID n~2398 Contig9 from SEQ ID n° 6969 PL-4154.1 1247850 to m No Hits found

1248293 #N/A ref ]NP_073225.1] ransposase of IS630 [Salmonella enterica serovar Choleraesuis] dbj |BAA01531.l|

Contig9 from

(D10689) M5 protein [Salmonella choleraesuis] SEQ ID n° 6970 PL-3153.1 1249069 to m 72% dbj |BAB20556.1 | (AB040415) ransposase of IS630

1250082

[Salmonella enterica serovar

Choleraesuis] SEQ ID n~2399

Contig9 from SEQ ID n° 6971 PL-4152.1 1250314 to m No Hits found

1250733 #N/A sp|Q56887|FLHA_YERΞN FLAGELLAR BIOSYNTHESIS

Contig9 from PROTEIN FLHA pir] | S54214 flagellar biosynthesis SEQ ID n° 6972 PL-3154.1 1251255 to m 88% protein flhA - Yersinia enterocolitica

1253336 emb|CAA88186.l| (Z48169) flhA [Yersinia enterocolitica] SEQ ID n~2400

TABLEAU II

sp|Q56886|FLHB_YEREN FLAGELLAR BIOSYNTHETIC

Contig9 from PROTEIN FLHB pir||S54213 flagellar biosynthetic SEQ ID n° 6973 PL-3156.1 1253329 to 813 protein flhB - Yersinia enterocolitica

Ï254480 emb|CAA88185.l| (Z48169) flhB [Yersinia enterocolitica] SEQ ID n~2402 sp|Q06584|PYS2_PSEAΞ PYOCIN S2 (KILLER PROTEIN)

^~ Contig9 from piTrf^~[D8 501 pyocin S2 PA1150 [imported] - SEQ ID n° 6974 PL-3157.2 1254786 to P 313 Pseudomonas aeruginosa (strain PAOl)

1256474 gb|AAG04539.l|AΞ004545_2 (AE004545) pyocin S2

[Pseudomonas aeruginosa] SEQ ID n-2403 sp ] P04T82^~| IMM2_ECOLI COLICIN E2 IMMDNITY PROTEIN

(IMME2) (MICROCIN Ξ2 IMMUNITY PROTEIN) pir| [IMECE2 colicin E2 immunity protein -

Contig9 from

Escherichia coli plasmids emb] CAA261 6.l| SEQ ID n° 6975 PL-4149.1 1256471 to p 653

(X02227) immE2 polypeptide [Escherichia coli]

1256728 gb|AAA23069.l| (M29885) colicin immunity protein

(ceiB) [Plasmid ColE2] emb|CAA25610.l| (X01163)

E2 immunity protein (aa 1-86) [Escherichia coli] #N/A

Contig9 from pir| |A56394 pyocin S3 - Pseudomonas aeruginosa SEQ ID n° 6976 PL-3943.1 1256825 to p 54% (strain P12) emb|CAA54958.l| (X77996) killer

1257313 protein of pyocin S3 [Pseudomonas aeruginosa] SEQ ID n-3102 pir| |B56394 pyocin S3 immunity protein -

Contig9 from

Pseudomonas aeruginosa (strain P12) SEQ ID n° 6977 PL-3944.1 1257310 to p 37% emb|CAA54959. l| (X77996) immunity protein of

1257780 pyocin S3 [Pseudomonas aeruginosa] SEQ ID n~3103 pir| |B56394 pyocin S3 immunity protein -

Contig9 from

Pseudomonas aeruginosa (strain P12) SEQ ID n° 6978 PL-3945.1 1257884 to p 35% emb]CAA5 959.l| (X77996) immunity protein of

1258351 pyocin S3 [Pseudomonas aeruginosa] SEQ ID n~3104 pir| |D82027 hypothetical protein NMA0318

Contig9 from [imported] - Neisseria meningitidis SEQ ID n° 6979 PL-4147.1 1258449 to p 44% (group A strain Z2491) emb | CAB83623.1 |

1258634 (AL162752) hypothetical protein NMA0318

[Neisseria meningitidis Z2491] #N/A

TABLEAU II

pir| |T44274 hypothetical protein [imported]

Contig9 from Synechococcus sp. (strain _ PCC7942) SEQ^{^}ID n° 6980 PL-4145.1 1259259 to m 51%- dbj |BAA37108.1 | (AB010691) putative ORF-3 1259510 -- [Synechococcus sp . ] #N/A

Contig9 from SEQ ID n° 6981 PL-4143.1 1260345 to m No Hits found ^" 1260767 #N/A sp|P40803]PKSK_BACSU PUTATIVE POLYKETIDE SYNTHASE PKSK (PKS) pir||A69679 polyketide synthase pksK - Bacillus subtilis

Contig9 fro gb|AAA85144.l| (U1103^"9^")^~ olyketide synthase SEQ ID n° 6982 PL-2029.1 1261416 to 54%

[Bacillus subtilis] emb| CAB13590. l| (Z99112)

1263266 polyketide synthase of type I [Bacillus subtilis] emb|CAB13601.l| (Z99113) polyketide synthase of type I [Bacillus subtilis] SEQ ID n~îl68

Contig9 from dbj |BAB06372.l| (AP001516) pyruvate SEQ ID n° 6983 PL-2030.2 1263259 to 32% dehydrogenase E2 .(dihydrolipoamide

1264824 acetyltransferase) [Bacillus halodurans] #N/A pir| |H72128 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) (EC 1.2.4.4) alpha/beta El chain CP0743 [similarity] -

Chlamydophila pneumoniae (strains

CWL029 and AR39) gb | AAD18186.1 | (AE001588)

(pyruvate) Oxoisovalerate Dehydrogenase Alpha &

Contig9 from

Beta Fusion [Chlamydophila pneumoniae SEQ ID n° 6984 PL-2031.2 1264834 to 533

CWL029] gb|AAF38548.l] (AE002233) 2-

1266831 oxoisovalerate dehydrogenase, El component, alpha and beta subunit [Chlamydophila pneumoniae AR39] dbj |BAA98245.1 | (AP002545)

(pyruvate) oxoisovalerate dehydrogenase alpha and beta fusion [Chlamydophila pneumoniae J138] #N/A

Contig9 from gb|AAG59094.l|AE005621_6 (AE005621) putative SEQ ID n^» 6985 PL-2032.1 1268501 to 68% glycoporin [Escherichia coli 0157 :H7]

1269907 SEQ ID n-î.172

TABLEAU II

Contig9 from SEQ ID n° 6986 PL-2033.1 1270940 to No Hits found __ 1271758 SEQ ID n~ïl73

Contig9 from gb|AAF17281.l| (AF204805) NosD [Nostoc sp . SEQ ID n° 6987 PL-2034.1 1271894 to 263 GSV224]

1284376 SEQ ID n~î.l74 pir| |H75515 tetracycline-efflux transporter -

Contig9 from Deinococcus radiodurans (strain RI) SEQ ID n° 6988 PL-2035.1 1284373 to 45% gb|AAF10051.l|AE001906_7 (AE001906) tetracycline

1285638 efflux transporter [Deinococcus radiodurans] SEQ ID n-î.175 pir| |τi4591 actinomycin synthetase II acmB

Contig9 from [imported] - Streptomyces chrysomallus SEQ ID n° 6989 PL-2036.1 1285667 to 60% gb|AAC38442.1 | (AF047717) actinomycin synthetase

1288864

II [Streptomyces chrysomallus] SEQ ID n-î.176

Contig9 from SEQ ID n° 6990 PL-4135.1 1288916 to No Hits found

1289275 #N/A Contig9 from SEQ ID n° 6991 PL-2037.1 1289663 to m No Hits found

1290526 SEQ ID n~î!77 pir| |D82481 multidrug résistance protein D

Contig9 from VCA0267 [imported] - Vibrio cholerae SEQ ID n° 6992 PL-2038.1 1290648 to m 293 (group 01 strain N16961) gb |AAF96178.1 |

1291886 (AΞ004366) multidrug résistance protein D

[Vibrio cholerae] SEQ ID n-î.178

Contig9 from

SEQ XD n° 6993 PL-2039.1 1291883 to m No Hits found

1293022 SEQ ID n~îl79 Contig9 from emb|CAC1114l.l| (AJ250581) NikS protein SEQ ID n° 6994 PL-2040.1 1293019 to m 283 [Streptomyces tendae]

1294182 SEQ ID n~îl81 Contig9 from dbj |BAB05302.1 | (AP001512) BH1583~unknown SEQ ID n° 6995 PL-3947.1 1294179 to m 313 conserved protein in others [Bacillus

1294583 halodurans] SEQ ID n~3105

TABLEAU II

Contig9 from emb|CAC12469.l| (AL445067) conserved

SEQ ID n° 6996 PL-2041.2 1294640 to m 293 hypothetical protein [Thermoplasma 1295425 acidophilum] #N/A ref |NP_070589.l| 3-isopropylmalate dehydratase, small subunit (leuD-2) [Archaeoglobus fulgidus] sp | 028513 ]LE24_ARCFU PUTATIVE 3-

ISOPROPYLMALATE JËHYDRATASE SMALL SUBUNIT

Contig9 from (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM SEQ ID n° 6997 PL-3948.2 1295422 to m 423 ISOMERASE) (IPMI) pir| |H69469 3-isopropylmalate

1295979 dehydratase, small subunit (leuD-2) homolog -

Archaeoglobus fulgidus gb |AAB89489.1 |

(AE000981) 3-isopropylmalate dehydratase, small subunit (leuD-2) [Archaeoglobus fulgidus] #N/A pir||C72394 hypothetical protein TM0291 -

Contig9 from Thermotoga maritima (strain MSB8) SEQ ID n° 6998 PL-2042.2 1295972 to m 533 gb|AAD35379.l|AE001711_2 (AE001711) 3-

1297213 isopropylmalate dehydratase, large subunit, putative [Thermotoga maritima] #N/A

Contig9 from emb|CAB91069.l| (AJ239033) homocitrate sythase 1 SEQ ID n° 6999 PL-4132.1 1297210 to 63% [Anabaena variabilis]

1297653 #N/A Contig9 from emb|CAB91068.l| (AJ239032) homocitrate synthase SEQ ID n° 7000 PL-2043.1 1297660 to 543 2 [Anabaena variabilis]

1298346 SEQ ID n-î.184 sp|P54950|YXEK_BACSU HYPOTHETICAL 49.3 KD

PROTEIN IN IDH-DEOR INTERGENIC REGION pir| |E70075 nitrilotriacetate monooxygenase (EC

Contig9 from 1.14.13.-) component A homolog yxeK - SEQ ID n° 7001 PL-2044.1 1298383 to m 663 Bacillus subtilis dbj |BAA08327.l| (D45912)

1299714 homologous to dszA gène product of Rhodococcus sp. [Bacillus subtilis] emb|CAB15988.l| (Z99124) similar to monooxygenase [Bacillus subtilis] SEQ ID n-î.185

a a a

H H ω M W

-d fi o en

4-1

-H W

O m

P. ft ft &

ro m o o o o o

H σ r- r- H o o fi fi fi

Q Q Q Q Q

H H H H H c* CX Ol

H m σ

H to TABLEAU II

sp|P07800 |CHEZ_SALTY CHEMOTAXIS PROTEIN CHEZ

Contig9 from pir| |A27088 _chemotaxis protein cheZ - Salmonella SEQ ID n° 7007 PL-2047.1 1303143 to typhimurium gb| AD15120.1 | (M16691) chez gène 130-3 93 product [Salmonella typhimurium] SEQ ID n~îl88 sp|P06657|CHEY_SALTY CHEMOTAXIS PROTEIN CHEY

Contig9 from pir| |QREBCY chemotaxis protein cheY [validated]

SEQ ID n° 7008 PL-412_7_.J. 13-0.3.80.3-to m 88

SalmoneTl typhiπHrium gb | AAA27037.11 (M12131)

1304192

CheY protein [Salmonella typhimurium] #N/A sp | P07330 | CHΞB_ECOLI PROTEIN-GLUTAMATE

METHYLESTERASE pir| | YECEB protein-glutamate methylesterase^" (EC 3.1.1.61) - Escherichia coli^"

Contig9 from dbj |BAA15699.l| (D90830) Protein-glutamate SEQ ID n° 7009 PL-2048.1 1304512 to 893 methylesterase (EC 3.1.1.61) .

1305564 [Escherichia coli] gb|AAC74953. l| (AE000282) response regulator for chemotaxis (cheA sensor) ,- protein methylesterase [Escherichia coli K12] SEQ ID n~îl89 sp|P0780l|CHER_SALTY CHEMOTAXIS PROTEIN

METHYLTRANSFERASE pir| | XYEBGM protein-glutamate

Contig9 from

O-methyltransferase (EC 2.1.1.80) - Salmonella SEQ ID n° 7010 PL-2049.1 1305557 to 733 typhimurium gb| AA27035.l[ (J02757)

1306444 methyltransferase (cheR; EC 2.1.1.24)

[Salmonella typhimurium] SEQ ID n~ai90 contigs from dbj |BAB38738.l| (AP002569) methyl-accepting SEQ ID n° 7011 PL-2050.2 1306451 to 643 chemotaxis protein I [Escherichia coli

1308085 0157 :H7] #N/A sp|P21822|MCPS_ENTAE METHYL-ACCEPTING CHEMOTAXIS

Contig9 from

SERINE TRANSDUCER pir| |C32302 serine transducer SEQ ID n° 7012 PL-2051.2 1308139 to 753 tse - Enterobacter aerogenes gb|AAA24797.l[

1309833

(M26411) tse [Enterobacter aerogenes] #N/A

TABLEAU II

sp|P07365|CHEW_ECOLI CHEMOTAXIS PROTEIN CHE pir| |QRECC purine binding chemotaxis protein cheW - Escherichia coli gb|AAA23565. l( (M13463) cheW peptide [Escherichia coli] dbj |BAA15703. l[

(D90830) Chemotaxis protein CheW [Escherichia

Contig9 from coli] dbj JBAA15708.l| (D90831) Chemotaxis _SEQ -ID n° 7013 PL-3951.2 1310010 tθ-_ _m- protein CheW [Escherichia^{- '}coli] gb| AAC74957.11

1310507

(AE000282) positive regulator of CheA protein activity [Escherichia coli K12] dbj |BAB36020.l| (AP002559) positive regulator of

CheA protein activity [Escherichia coli 0157 :H7] #N/A sp|P09384 |CHEA_SALTY CHEMOTAXIS PROTEIN CHEA

Contig9 from pir| |A28959 chemotaxis protein cheA - Salmonella SEQ ID n° 7014 PL-2052.1 1310561 to m 773 typhimurium gb|AAA27034.l| (J03611) sensory

1312612 protein (cheA; gtg start codon) [Salmonella typhimurium] SEQ ID n~1194 sp|P09349|MOTB_ECOLI CHEMOTAXIS MOTB PROTEIN

(MOTILITY PROTEIN B) pir| | QRECMB chemotaxis protein motB - Escherichia coli gb|AAA24l78.1 |

(J01652) motB protein for chemotaxis

[Escherichia coli] db |BAA15710.l| (D90831)

Contig9 from Chemotaxis MotB protein (Motility protein B) . SEQ ID n° 7015 PL-2053.1 1312615 to m 69% [Escherichia coli] gb| AAC74959.1 |

1313616 (AE000282) enables flagellar motor rotation, linking torque machinery to cell wall

[Escherichia coli K12] gb| AAG56879.1 | AE005411_3

(AE005411) enables flagellar motor rotation, linking torque machinery to cell wall

[Escherichia coli Ol57:H7] SEQ ID n~£195 sp|P5589l|MOTA_SALTY CHEMOTAXIS MOTA PROTEIN

Contig9 from

(MOTILITY PROTEIN A) gb|AAC45265.1 j (U81861) SEQ ID n° 7016 PL-2054.1 1313613 to 693

MotA [Salmonella typhimurium] dbj |BAA85316.l|

1314500

(D43640) MotA protein [Salmonella typhimurium] SEQ ID n~1196

TABLEAU II

Contig9 from sp | Q9X9F3 | FLHC_XENNE FLAGELLAR TRANSCRIPTIONAL SEQ ID n° 7017 PL-3952.1 1314637 to m 94% ACTIVATOR FLHC emb| CAB41408.1 | (AJ012828) FlhC 1315218 protein [Xenorhabdus nematophilus] SEQ ID n~3110

Contig9 from sp | Q9X9F2 | FLHD_XENNE FLAGELLAR TRANSCRIPTIONAL SEQ ID n° 7018 PL-4123.1 1315222 to m 89% ACTIVATOR FLHD emb | AB41407.1 | (Aσ012828) FlhD

1315575 protein [Xenorhabdus nematophilus] #N/A pir||C83044 Mg(2+) transport ATPase, P-type 2

PA4825 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 7019 PL-4121.1 1317840 to m 41% gb|AAG08210.l|AE004895_10 (AE004895) Mg(2+) 1317998 transport ATPase, P-type 2 [Pseudomonas aeruginosa] #N/A pir||C83044 Mg(2+) transport ATPase, P-type 2

PA4825 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 7020 PL-4120.1 1318135 to m 50' gb|AAG08210.l|AE004895_10 (AE004895) Mg(2+)

1318317 transport ATPase, P-type 2 [Pseudomonas aeruginosa] #N/A

Contig9 from SEQ ID n° 7021 PL-4119.1 1318611 to No Hits found

1318781 #N/A sp|P22037|ATMC_SALTY MG(2+) TRANSPORT ATPASE

PROTEIN C pir| |A39083 Mg2+-transporting ATPase

Contig9 from

(EC 3.6.1.-) mgtC - Salmonella typhimurium SEQ ID n° 7022 PL-2055.3 1319372 to m 693 gb|AAA72083.l| (M57715) Mg2+ transport ATPase

1320082

[Salmonella typhimurium] gb| AD16960.1 |

(AF106566) MgtC [Salmonella typhimurium] #N/A

Contig9 from SEQ ID n° 7023 PL-7224.1 1320612 to No Hits found

1320845 #N/A

TABLEAU II

sp|P77523 |YLAC_ΞCOLI HYPOTHETICAL 19.8 KDA

PROTEIN IN TESB-HHA INTERGENIC REGION pir| |A64776 probable membrane protein ylaC -

Escherichia coïï g |AAB40213.1 | (U82664)

Contig9 from hypothetical [Escherichia coli] gb[AAC73560.l( SEQ ID n° 7024 PL-3953.3 1321242 to 543 (AE000152) orf, hypothetical protein

1321748 [Escherichiâ^côTi K121 gb | AAG54807.11 E005225_1

(AE005225) orf, hypothetical protein

[Escherichia coli 0157 :H7 EDL933] dbj |BAB33934.l| (AP002551) hypothetical protein

[Escherichia coli 0157 :H7] #N/A-

Contig9 from SEQ ID n° 7025 PL-2056.1 1322114 to m No Hits found

1323190 SEQ ID n~îl98 Contig9 from pir[ (T44463 integrase int [imported] - Shigella SEQ ID n° 7026 PL-4115.1 1324941 to p 473 flexneri gb] AAD44730. l| F141323_1 (AF141323)

1325198 Int [Shigella flexneri] #N/A sp|P393 7|lNTB_ECOLI PROPHAGE P4 INTEGRASE

(INT(P4)) pir||S56496 prophage P4 integrase -

Contig9 from

Escherichia coli gb[AAA97167.1 [ (U14003) SEQ ID n° 7027 PL-2057.1 1325101 to p 66%

ORF_o396 [Escherichia coli] gb [AAC77227.1 |

1326204

(AE000498) prophage P4 integrase [Escherichia coli K12] SEQ ID n~!199

Contig9 from pir| |τi8372 repeat organellar protein - SEQ ID n° 7028 PL-2058.1 1326288 to m 20% Plasmodium chabaudi gb| AAC63403.1 | (U43145)

1328021 repeat organellar protein [Plasmodium chabaudi] SEQ ID n~HL200 Contig9 from SEQ ID n° 7029 PL-2059.1 1328081 to m No Hits found

1329166 SEQ ID n~î201 Contig9 from SEQ ID n° 7030 PL-4114.1 1329583 to m No Hits found

1329696 #N/A ref |NP_058387.l| orf; hypothetical protein

Contig9 from

[Salmonella typhi] gb|AAF70012. l| AF250878_173 SEQ ID n° 7031 PL-2060.2 1329883 to p

(AF250878) orf; hypothetical protein [Salmonella

1331478 typhi] #N/A

TABLEAU II

Contig9 from

SEQ ID n° 7032 PL-2061.1 1331534 to No Hits found

1332514 SEQ ID n-î.204

Contig9 from

SEQ ID n° 7033 PL-4113.1 1332511 to m No Hits found

1332648 #N/A

Contig9 from

SEQ ID n° 7034 PL-4112.1 1332849 to m No Hits found

1333169 #N/A

Contig9 from

^~SEQ ID n° 7035 PL-4111.1 1333159 to ^_m No^~ Hits found

1333548 #N/A

Contig9 from

SEQ ID n° 7036 PL-4110.1 1333991 to No Hits found

1334191 #N/A ref |NP_047290.l| nicking enzyme (traA)

Contig9 from [Lactococcus lactis] pir| [T43077 probable SEQ ID n° 7037 PL-2062.1 1334349 to 25% relaxase - Lactococcus lactis plasmid pMRCOl

1335863 gb|AAC55993.l| (AE001272) nicking enzyme (traA)

[Lactococcus lactis] SEQ ID n~£205 pir||S77439 hypothetical protein slrll35 -

Contig9 from

Synechocystis sp. (strain PCC 6803)

SEQ ID n° 7038 PL-2063.1 1335924 to 473 dbj |BAA17286.1 | (D90905) hypothetical protein

1337798

[Synechocystis sp . ] SEQ ID n~î206

Contig9 from

SEQ ID n° 7039 PL-4108.1 1338055 to No Hits found

1338228 #N/A

Contig9 from gb|AAG58108.l|AΞ005527_ll (AE005527) putative

SEQ ID n° 7040 PL-4106.1 1338456 to m 623 transposase [Escherichia coli 0157:H7]

1338803 #N/A

TABLEAU II

pir| |C81839 probable transposase for IΞ1655

NMA1481 [imported] - Neisseria meningitidis (group B strain MD58, group A Contig9 from

^"strain Z2491) emb|CAB84714.l| (AL162756) ^~~'

SEQ ID n° 7041 PL-2064.1 1339178 to 603 putative transposase for IS1655 [Neisseria

1340146 meningitidis Z2491] emb|CAB84719.1 |

(ÂL162756) putative transposase for IS1655

[Neisseria meningitidis Z2491] SEQ ID n~î207

Contig9 from

SEQ ID n° 7042 PL-4104.1 1340221 to No Hits found

1340532 #N/A

Contig9 from

SEQ ID n° 7043 PL-4103.1 1340620 to m No Hits found

1340949 #N/A

Contig9 from gb[AAG57759.l|AE005493_12 (AE005493) Z3947 gène

SEQ ID n° 7044 PL-2065.1 1341477 to m 433 product [Escherichia coli 0157 :H7]

1342325 SEQ ID n~£208

Contig9 from gb|AAC26596.l| (U83995) putative protease

SEQ ID n° 7045 PL-2066.1 1342672 to 59% [Porphyro onas gingivalis]

1343556 SEQ ID n-2.209 sp | PO5020 | YRC_ECOLI DIHYDROOROTASE (DHOASE) pir| |DΞEC00 dihydroorofase (EC 3.5.2.3) - Escherichia coli emb| CAA28157.1 | (X04469)

Contig9 from dihydroorofase [Escherichia coli] SEQ ID n° 7046 PL-2067.1 1343947 to 78% gb|AAA24482.l| (M16752) dihydroorofase (EC

1344999 3.5.2.3) [Escherichia coli] dbj | BAA35870.1 |

(D90743) Dihydroorofase (EC 3.5.2.3).

[Escherichia coli] gb |AAC74146.1 | (AE000207) dihydro-orotase [Escherichia coli K12] SEQ ID n~1210

Contig9 from dbj |BAA35857.l| (D90742) ORF_ID:o233#8

SEQ ID n° 7047 PL-4101.1 1345192 to 68% [Escherichia coli] dbj |BAA35868. l| (D90743)

1345446 ORF_ID:o233#8 [Escherichia coli] #N/A

Contig9 from pir| |A45828 colanic acid capsular biosynthesis

SEQ ID n° 7048 PL-2068.1 1345650 to 403 activation protein A - Erwinia

1346252 amylovora SEQ ID n~!211

TABLEAU II

Contig9 from pir[ [S16889 hypothetical protein 39.9 - SEQ ID n° 7049 PL-2069.1 1346298 to 833 Escherichia coli emb | CAA43318. l[ (X61000)

1347356 Orf 9.9 [Escherichia coli] SEQ ID n-1212 sp | Q9S3S0 | DINI_SERMA DNA-DAMAGE-INDUCIBLE

Contig9 from

PROTEIN I gb(AAD50308.l[AF175466_2 (AF175466) SEQ ID n° 7050 PL-4100.1 1347600 to m 58%

DNA damage-inducible protein DinI [Serratia

1347860^r= =

^_marcescens] #N/A sp|P24187(HTRB_ECOLI LIPID A BIOSYNTHESIS

LAUROYL ACYLTRANSFERASE (HEAT SHOCK PROTEIN B) pir] ]S16888 lipid A biosynthesis lauroyl acyltransferase (EC 2.3.1.-) -

Escherichia coli emb| CAA43317. l| (X61000) HtrB

Contig9 from protein [Escherichia coli] dbj |BAA35863. l( SEQ ID n° 7051 PL-2070.1 1348123 to 77%

(D90743) HtrB protein. [Escherichia coli]

1349064 gb|AAC74138.l| (AE000206) heat shock protein

[Escherichia coli K12] db |BAA35852.l| (D90742)

HtrB protein.- [Escherichia coli] gb|AAG55800.l|AE005316_5 (AE005316) Z1690 gène product [Escherichia coli 0157 :H7] SEQ ID n~1214 sp|P94408|YCLF_JBACSU HYPOTHETICAL 53.3 KD

PROTEIN IN SFP-GERKA INTERGENIC REGION pir| [C69762 di-tripeptide ABC transporter

(membrane pr) homolog yclF - Bacillus

Contig9 from subtilis dbj |BAA09000.l| (D50453) homologue of SEQ ID n° 7052 PL-2071.1 1349788 to 563

Di-tripeptide transporter Dtp of L. lactis

1351326

[Bacillus subtilis] emb| CAB12175. l| (Z99106) similar to di-tripeptide ABC transporter

(membrane protein) [Bacillus subtilis] SEQ ID n~î215 pir| |E82467 probable antidote protein VCA0392

Contig9 from

[imported] - Vibrio cholerae (group 01 SEQ ID n° 7053 PL-4099.1 1351534 to m 67%

Strain N16961) gb] AF96298.1 | (AE004374)

1351860 antidote protein, putative [Vibrio cholerae] #N/A

TABLEAU II

pir| [H83242 probable transcription regulator PA3220 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ I-D-n°-7054—PL-2072.1 1352230 to m 47% gb|AAG06608.l|AE004745_5 (AE004745) probable

1352937 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~£216

^— pir| |A83243 CsaA protein PA3221 [imported] -

Contig9 from Pseudomonas aeruginosa (strain PAOl) SEQ ID n° 7055 PL-4097.2 1352994 to 73 gb|AAG06609.l|AE004745_6 (AE004745) CsaA protein

1353329 [Pseudomonas aeruginosa] #N/A

Contig9 from SEQ ID n° 7056 PL-4095.2 1353599 to m No Hits found

1353958 #N/A Contig9 from dbj |BAB06659.1| (AP001517) BH2 40-unknown SEQ ID n° 7057 PL-2073.1 1354167 to m 383 conserved protein [Bacillus halodurans]

1355000 SEQ ID n~î217 p r] |D83628 probable aldéhyde dehydrogenase

Contig9 from PAO130 [imported] - Pseudomonas SEQ ID n° 7058 PL-2074.1 1355304 to p 67% aeruginosa (strain PAOl)

1356815 gb|AAG03520.l|AE004451_l (AE004451) probable aldéhyde dehydrogenase [Pseudomonas aeruginosa] SEQ ID n~î.218

Contig from dbj |BAB06037.l| (AP001515) malonic semialdehyde SEQ ID n° 7059 PL-2075.1 1356832 to p 70% oxidative decarboxylase [Bacillus

1358766 halodurans] SEQ ID n~ï219 Contig9 from sp | 068965 |MI2D_RHIME MYO-INOSITOL 2- SEQ ID n° 7060 PL-2076.1 1359132 to p 57% DEHYDROGENASE gb | AAC70005.1 | (AF059313) myo-

1360118 inositol dehydrogenase [Sinorhizobium meliloti] SEQ ID n~î220 Contig9 from gb|AAG58882.l|AE005599_14 (AE005599) putative SEQ ID n° 7061 PL-2077.1 1360222 to p 60% cotransporter [Escherichia coli 0157 :H7]

1361937 SEQ ID n~1221 Contig9 from dbj |BAB04429.l| (AP001509) BH0710-unknown SEQ ID n° 7062 PL-2078.1 1362472 to p 56% conserved protein [Bacillus halodurans]

1363605 SEQ ID n~£222 Contig9 from dbj |BAB06038.l| (AP001515) myo-inositol SEQ ID n° 7063 PL-2079.1 1363681 to p 27% catabolism [Bacillus halodurans]

1365585 SEQ ID n-î.223

TABLEAU II

Contig9 from gb|AAC3ll80.l[ (AF076240) MocC [Rhizobium SEQ ID n° 7064 PL-2080.1 1365615 to 643 leguminosarum bv. viciae]

1366505 SEQ ID n~£225 sp|P42413|IOLB_BACSU IOLB PROTEIN pir||B69645 myo-inositol catabolism iolB - Bacillus subtilis

Contig9 from dbj |BAA03291.l| (D14399) hypothetical protein

SEQ ID n° 7065 PL-2081.-1 1366-553 to 573

[Bacillus^" subtilis] ^"~ emb | CAB16011.11 (Z99124)

1367380 alternate gène name: yxdB-myo-inositol catabolism [Bacillus subtilis] SEQ ID n~!226 pir| |T33922 hypothetical protein Y8A9A.2 -

Caenorhabditis elegans gb|AADl285 ,l|

Contig9 from

(AF125461) contains similarity to thrombospondm SEQ ID n° 7066 PL-3955.1 1367343 to m 35% type 1 domains (Pfam:PF00090,

1367786

Score=l.l E= 0.49, N=8) [Caenorhabditis elegans] SEQ ID n~3113 pir( |T33922 hypothetical protein Y8A9A.2 -

Caenorhabditis elegans gb|AAD1285 .l|

Contig9 from

(AF125461) contains similarity to thrombospondm SEQ ID n° 7067 PL-3956.1 1367832 to m 443 type 1 domains (Pfam:PF00090,

1368311

Score=l.l E= 0.49, N=8) [Caenorhabditis elegans] SEQ ID n~3114

Contig9 from gb|AAK02392.l| (AE006066) unknown [Pasteurella SEQ ID n° 7068 PL-3957.1 1368965 to 503 multocida]

1369519 SEQ ID n~3115 Contig9 from gb|AAK02391.l| (AΞ006066) unknown [Pasteurella SEQ ID n° 7069 PL-2082.1 1369529 to m 67% multocida]

1370542 SEQ ID n~ï227 Contig9 from gb|AAK02390.l| (AE006066) unknown [Pasteurella

SEQ ID n° 7070 PL-2083.1 1370556 to 50% multocida]

1371534 SEQ ID n~1228 Contig9 from gb|AAK02389.l| (AE006066) unknown [Pasteurella

SEQ ID n° 7071 PL-2084.1 1371531 to 453 multocida]

1372889 SEQ ID n~3 229

TABLEAU II

pir| |B82474 hypothetical protein VCA0312 VCA0386

[imported] - vibrio cholerae (group 01

1373829 (AEO04370) hypothetical protein [Vibrio cholerae] gb|AAF96292.l| (AE004374) hypothetical protein^{^}[VïE ιo^"chôlerae] #N/A

Contig9 from gb|AAK02396.l| (AE006067) unknown [Pasteurella

SEQ ID n° 7073 PL-2085.1 1373923 to m 583 multocida]

1377204 SEQ ID n~î230

Contig9 frσπr

SEQ ID n° 7074 PL-4088.1 1377201 to m No Hits found

1377329 #N/A

Contig9 from

SEQ ID n° 7075 PL-4087.1 1377380 to No Hits found

1377520 #N/A

Contig9 from

SEQ ID n° 7076 PL-3958.1 1378106 to m No Hits found

1378645 SEQ ID n~3116

Contig9 from db |BAB06239.1] (AP001515) transposase related

SEQ ID n° 7077 PL-2086.1 1378849 to 213 protein (20) [Bacillus halodurans]

1379874 SEQ ID n~1231

Contig9 from

SEQ ID n° 7078 PL-4085.1 1380672 to m No Hits found

1380956 #N/A

Contig9 from dbj |BAA35736.l| (D90734) ORF_ID : θ224#4

SEQ ID n° 7079 PL-7014.1 1380961 to 593 [Escherichia coli]

1381053 #N/A

Contig9 from gb[AAG55455.l| EO05287_2 (AE005287) yccK gène

SEQ ID n° 7080 PL-4084.1 1381238 to product [Escherichia coli 0157 :H7]

1381573 #N/A

Contig9 from dbj |BAA35733.l| (D90734) Acylphosphatase (EC

SEQ ID n° 7081 PL-4083.1 1381587 to m 583 3.6.1.7) Ch2, skeletal muscle

1381865 [Escherichia coli] #N/A

TABLEAU II

sp[P75875|YCCV_ECOLI HYPOTHETICAL 13.8 KDA

PROTEIN IN MGSA-HYAA INTERGENIC REGION pir| |E64837 yccV protein - Escherichia coli Contig9 from gb|AAC74052.l| (AE000198) orf, hypothetical

SEQ ID n° 7082 PL-4082.1 1382089 to 803 protein [Escherichia coli K12] dbj |BAA35731.1 |

1382409

(D90734) ORF_ID:θ223#ll [Escherichia coli] ^τ=gb|AAG55452.l|AE005286_ll (AE005286) yccV genë^" product [Escherichia coli 0157 :H7] #N/A

Contig9 from SEQ ID n° 7083 PL-4079.1 1382882 to p No Hits found 1383109 #N/A

Contig9 from gb|AAK03925.l| (AE006222) unknown [Pasteurella SEQ ID n° 7084 PL-3959.1 1383163 to 27% multocida]

1383528 SEQ ID n~3117 Contig9 from dbj |BAA35730.l| (D90734) ORF_ID:θ223#10 SEQ ID n° 7085 PL-3960.1 1384340 to 703 [Escherichia coli]

1384753 SEQ ID n~3119 pir| |B64837 methylglyoxal synthase (EC

4.2.99.11) - Escherichia coli gb|AAC74049.l|

(AE000198) methylglyoxal synthase [Escherichia

Contig9 from coli K12] dbj |BAA35728.l| (D90734) Hypothetical SEQ ID n° 7086 PL-3961.1 1384876 to 773 protein in held 3 ' région . [Escherichia coli]

1385334 gb|AAG55449.l|AE005286_8 (AE005286) methylglyoxal synthase [Escherichia coli

0157 :H7] SEQ ID n~3120 sp|P15038|HΞLD_ECOLI HELICASE IV (75 KD

HELICASE) pir| ]HJECD4 helicase (EC 3.6.1.-) IV

Contig9 from

Escherichia coli dbj |BAA35727. l| (D90734)

SEQ ID n° 7087 PL-2087.1 1385457 to 76%

Helicase (EC 3.6.1.-) IV. [Escherichia coli]

1387511 gb|AAC74048.l| (AΞ000198) DNA helicase IV

[Escherichia coli K12] SEQ ID n~1232

TABLEAU II

sp|P75870 |YCCS_ECOLI HYPOTHETICAL 82.0 KDA

PROTEIN IN SULA-HELD INTERGENIC REGION pir| |G64836 probable membrane protein yccS -

Contig9 from Escherichia coli gb | AAC74046. l| (AE000198) orf, SEQ ID n° 7088 PL-2088.1 1387722 to 763 hypothetical protein [Escherichia coli K12]

1389863 db] |BAA35718.l| (D90733) Hypothetical protein

HI1680 [Escherichia coli] dbj [BAA35725.1 |

(D90734) Hypothetical protein HI1680

[Escherichia coli] SEQ ID n~i233 sp|P75869|YCCR_ECOLI HYPOTHETICAL 24.1 KDA

PROTEIN IN^"^ULA-HELD INTERGENIC REGION pir] |F64836 probable membrane protein b0959 -

Contig9 from

Escherichia coli gb | AAC74045.1 | (AE000198) orf, SEQ ID n° 7089 PL-2089.2 1389923 to m 473 hypothetical protein [Escherichia coli K12]

1390525 dbj (BAA35717.l| (D90733) ORF_ID :o223#4 [Escherichia coli] dbj |BAA35724.1 | (D90734)

0RF_ID:o223#4 [Escherichia coli] #N/A sp|P08845|SULA_SERMA CELL DIVISION INHIBITOR

Contig9 from pir| |D29016 cell division inhibitor sulA - SEQ ID n° 7090 PL-3962.2 1390774 to 603

Serratia marcescens gb | AAA26582.1 | (M16468)

1391307 sulA protein [Serratia marcescens] #N/A sp|P04845|θMPA_SERMA OUTER MEMBRANE PROTEIN A

Contig9 from PRECURSOR pir| |S07298 outer membrane protein SEQ ID n° 7091 PL-3131.2 1391992 to 81% ompA precursor - Serratia marcescens

1393098 emb|CAA25254.l| (X00618) ompA protein [Serratia marcescens] SEQ ID n-2375

TABLEAU II

sp|P 5569|YCBG_ECOLI HYPOTHETICAL 17.7 KDA

PROTEIN IN FABA-OMPA INTERGENIC REGION pir| [C64836 ycbG protein - Escherichia coli gb|AAC74042.l| (AE000198) putative dehydrogenase

Contig9 from [Escherichia coli K12] dbj |BAA35714.l| (D90733) SEQ ID n° 7092 PL-3963.1 1393248 to 853 Hypothetical protein in ompA 3 'région .

1393703 [Escherichia coli] dbj |BAA3572Ï7ï| 1D90734)

Hypothetical protein in ompA 3 'région .

[Escherichia coli] gb| AAG55442.1 | AE005286_1

(AE005286) putative dehydrogenase [Escherichia

COli 0157:H7] ^{"" "} SEQ ID n~3122

Contig9 from gb|AAG55441.l|AE005285_8 (AE005285) putative ATP'

SEQ ID n° 7093 PL-3132.1 1393910 to 633 dépendent protease [Escherichia coli

1395640 0157 :H7] SEQ ID n~2376 sp | P18391 | FABA_ECOLI 3-HYDROXYDECANOYL- [ACYL- CARRIER-PROTEIN] DEHYDRATASE (BΞTA- HYDROXYDECANOYL THIOESTER DEHYDRASE) pir| |DWECHD 3 -hydroxydecanoyl- [acyl-carrier- protein] dehydratase (EC 4.2.1.60) Escherichia coli gb|AAA96496.l| (J03186) D-3- hydroxydecanoyl- (acyl carrier-protein) dehydratase [Escherichia coli]

Contig9 from dbj |BAA35712.l| (D90733) 3 -hydroxydecanoyl- [acyl- SEQ ID n° 7094 PL-3964.1 1395724 to 813 carrier-protein] dehydratase (EC

1396242 4.2.1.60) (beta-hydroxydecanoyl thioester dehydrase) . [Escherichia coli] gb|AAC74040.l| (AE000197) beta-hydroxydecanoyl thioester dehydrase, trans-2-decenoyl- ACP isomerase [Escherichia coli K12] gb[AAG55440.l|AE005285_7 (AE005285) beta- hydroxydecanoyl thioester dehydrase, trans-2-decenoyl-ACP isomerase [Escherichia coli

0157 :H7] SEQ ID n~3123

Contig9 from SEQ ID n° 7095 PL-4076.1 1396367 to m No Hits found

1396555 #N/A

TABLEAU II

Contig9 from SEQ ID n° 7096 PL-4075.1 1396668 to No Hits found

1397006 #N/A

Contig9 from pir||S3619l ribosome modulation factor - SEQ ID n° 7097 PL-4074.1 1397588 to 483 Escherichia coli emb | CAA49706.1 | (X70111)

1397755 ribosome modulation factor [Escherichia coli] #N/A

Contig9 from dbj |BAA35710.l| (D90733) ORF_ID:θ222#5 SEQ ID n° 7098 PL-3965.2 1398002 to 693 [Escherichia coli]

1398565 #N/A gb|AAG55437.l|AE005285_4 (AE005285) paraquat- Contig9 f om dûcible protein B [Escherichia coli 0157 :H7

SEQ ID n° 7099 PL-3133.2 1398562 to m 79% EDL933] dbj |BAB34458.l| (AP002554) paraquat-

1400211 inducible protein B [Escherichia coli 0157 :H7] #N/A sp|P43670 |PQIA_ECOLI PARAQUAT-INDUCIBLE PROTEIN A pir| |E64835 paraquat-inducible protein pqiA -

Contig9 from

Escherichia coli dbj |BAA35708.1 | (D90733) SEQ ID n° 7100 PL-3134.1 1400232 to m 743

Paraquat-inducible protein A. [Escherichia coli]

1401479 gb|AAC74036.l| (AE000197) paraquat-inducible protein A [Escherichia coli K12] SEQ ID n~2378 sp[P43672[UUP_EC0LI ABC TRANSPORTER ATP-BINDING

PROTEIN UUP pir| |D64835 ABC-type transport

Contig9 from protein uup - Escherichia coli gb|AAC74035.l| SEQ ID n° 7101 PL-3135.1 1401569 to 863 (AE000197) putative ATP-binding component of a

1403479 transport system [Escherichia coli

K12] dbj |BAA35707.l| (D90733) Hypothetical protein HI1300 [Escherichia coli] SEQ ID n~2379 sp]P75864|YCBY_EC0LI HYPOTHETICAL 78.9 KDA

PROTEIN IN PYRD-PQIA INTERGENIC REGION pir| |C64835 hypothetical protein b0948 -

Contig9 from Escherichia coli gb| AAC7403 .l| (AE000197) SEQ ID n° 7102 PL-3136.1 1403485 to m 843 putative oxidoreductase [Escherichia coli K12]

1405617 dbj |BAA35703.l| (D90732) Hypothetical protein

HI0115 [Escherichia coli] dbj |BAA35706. l|

(D90733) Hypothetical protein HI0115

[Escherichia coli] SEQ ID n~2380

TABLEAU II

Contig9 from gb|AAG55433.l|AE005284_ll (AE005284) orf,

SEQ ID n° 7103 PL-3137.1 1405705 to 763 hypothetical protein [Escherichia coli 0157 :H7]

1406820 SEQ ID n-2381

Contig9 from dbj |BAA83130.l| (AB023953) N-glycosylation

SEQ ID n° 7104 PL-3138.2 1407098 to 48% [Saccharothrix aerocolonigenes]

1408396 #N/A

Contig9 from gb|AAC26596.l| (U83995) putative protease

SEQ ID n° 7105 PL-3139.2 1408614 to 59% [Porphyromonas gingivalis]

1409498 #N/A

Contig9 from dbj |BAA83130.l| (AB023953) N-glycosylation

SEQ ID n° 7106 PL-3140.1 1409620- to — p 503 [Saccharothrix aerocolonigenes]

1410915 SEQ ID n~2385

Contig9 from gb|AAG55432.l|AE005284_10 (AE005284) orf,

SEQ ID n° 7107 PL-3966.1 1411301 to 63^ hypothetical protein [Escherichia coli 0157.-H7]

1411846 SEQ ID n~3125 sp | P05021 | PYRD_ECOLI DIHYDROOROTATE

DEHYDROGENASE (DIHYDROOROTATE OXIDASE)

(DHODEHASE) (DHODASΞ) (DHOD) pir] | DEECDO dihydroorotate oxidase (EC 1.3.3.1)

Escherichia coli emb|CAA2659 ,l| (X02826)

Contig9 from dehydroorotate dehydrogenae (aa 1-336) SEQ ID n° 7108 PL-3141.1 1412163 to 85% [Escherichia coli] dbj |BAA35700. l| (D90732)

1413173 Dihydroorotate oxidase (EC 1.3.3.1)

[Escherichia coli] gb |AAC74031.l| (AE000196) dihydro-orotate dehydrogenase [Escherichia coli

K12] gb|AAG55431.l|AE005284_9 (AΞ005284) dihydro-orotate dehydrogenase [Escherichia coli

0157 :H7] SEQ ID n~2386

Contig9 from

SEQ ID n° 7109 PL-4072.1 1413239 to m No Hits found

1413397 #N/A

Contig9 from

SEQ ID n° 7110 PL-4071.1 1413517 to m No Hits found

1413684 #N/A

TABLEAU II

Contig9 from gb|AAG55417.l|AE005283_4 (AE005283)

SEQ ID n° 7111 PL-3142.1 1413860 to 853 aminopeptidase N [Escherichia coli 0157 :H7]

1416472 SEQ ID n~2387 sp I P18133 | NCB_EC0LI NICOTINATE

PHOSPHORIBOSYLTRANSFERASΞ (NAPRTASE) pir||jQ0756 nicotinate phosphoribosyltransferase

^"(ΕC^~~2.4.2.11) - Escherichia côTi gb|AAA24400.l| (J05568) nicotinic acid

Contig9 from phosphoribosyl transferase (pncB) (EC

SEQ ID n° 7112 PL-3143.1 1416818 to 78%

2.4.2.11) [Escherichia coli] dbj |BAA35683. l|

1418032

(D90731) Nicotinate phosphoribosyltransferase

(EC 2.4.2.11) [Escherichia coli] gb|AAC74017.1] (AEO00195) nicotinate phosphoribosyltransferase [Escherichia coli

K12] SEQ ID n~2388 sp|P17242|SYN_ECOLI ASPARAGINYL-TRNA SYNTHETASE

(ASPARAGINE--TRNA LIGASE) (ASNRS) pirj | SYECNT asparagine- -tRNA ligase (EC 6.1.1.22) -

Escherichia coli emb| CAA48274. l| (X68192)

Asparaginyl-tRNA synthetase [Escherichia coli]

Contig9 from gb|AAA24666.l] (M33145) asparaginyl-tRNA

SEQ ID n° 7113 PL-3144.1 1418237 to 93% synthetase (asnS) [Escherichia coli]

1419637 dbj |BAA35682.l| (D90731) Asparaginyl-tRNA synthetase (EC 6.1.1.22) (asparagine tRNA ligase) (asnRS) . [Escherichia coli] gb(AAC74016.l| (AE000195) asparagine tRNA synthetase [Escherichia coli K12] SEQ ID n~2389 sp|Q56828|0MPF_XENNE OUTER MEMBRANE PROTEIN F

PRECURSOR (PORIN OMPF) (OUTER MEMBRANE

PROTEIN OPNP) pir|]S70847 outer membrane porin

Contig9 from opnP precursor - Xenorhabdus nematophilus SEQ ID n° 7114 PL-3145.4 1419974 to 723 gb|AAB41114.l| (L40919) OmpF-like protein

1421119 precursor [Xenorhabdus nematophila] prf | | 2204378A OmpF-like porin [Xenorhabdus nematophilus] #N/A

TABLEAU II

sp|Q56828|0MPF_XENNE OUTER MEMBRANE PROTEIN F PRECURSOR (PORIN OMPF) (OUTER MEMBRANE

PROTEIN OPNP) pirJJJ370847 outer membrane porin

Contig9^~from opnp precursor - Xenorhabdus nematophilus SEQ ID n° 7115 PL-6661.2 1421625 to p 753 gb|AAB41114.l| (L40919) OmpF-like protein

1422791 precursor [Xenorhabdus nematophila] prf | ]2204378A OmpF-like porin [Xenorhabdus nematophilus] #N/A

Contig9 from pdb|lART| Aspartate Aminotransferase SEQ ID n° 7116 PL-3035.2 1423013 to 84% (E.C.2.6.1.1) Complexed With

1424203 Pyridoxal-5 ' -Phosphate And 2-Methylaspartate #N/A Contig9 from gb|AAG55412.l|AE005282_7 (AE005282) orf, SEQ ID n° 7117 PL-3034.1 1424620 to 773 hypothetical protein [Escherichia coli 0157 :H7]

1425267 SEQ ID n~2267 sp|P75848|YCBK_ECOLI HYPOTHETICAL 20.4 KDA

PROTEIN IN MUKB-ASPC INTERGENIC REGION pir| |E64832 ycbK protein precursor - Escherichia

Contig9 from coli gb] AC74012.l| (AE000195) orf, SEQ ID n° 7118 PL-3033.1 1425313 to m 73% hypothetical protein [Escherichia coli K12]

1425861 dbj |BAA35672.l[ (D90730) Hypothetical protein

HI1666 [Escherichia coli] dbj |BAA35678.1 |

(D90731) Hypothetical protein HI1666

[Escherichia coli] SEQ ID n~2266

Contig9 from gb|AAG55410.l|AE005282_5 (AE005282) putative

SEQ ID n° 7119 PL-3032.1 1425954 to m 743 amidase [Escherichia coli 0157 :H7]

1427309 SEQ ID n~2265

Contig9 from gb|AAG00942.l|AF272977_2 (AF272977) transposase

SEQ ID n° 7120 PL-3031.1 1427356 to 293 [Mycoplasma hyopneumoniae]

1428972 SEQ ID n~2264 sp|P22525| CBB_ECOLI HYPOTHETICAL 67.8 KDA

PROTEIN IN MUKB-ASPC INTERGENIC REGION

Contig9 from pir| |D64832 ycbB protein precursor - Escherichia SEQ ID n° 7121 PL-6658.1 1429075 to m 323 coli gb|AAC74011. l| (AE000194) putative amidase

1429440 [Escherichia coli K12] dbj |BAA35671.l| (D90730)

Hypothetical protein 63 (MukB 3 ' région)

[Escherichia coli] #N/A

TABLEAU II

pir||C83186 probable transcription regulator PA3678 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) ^~SE0f^~Iir-n^o— 7122 PL-3030 . 1 1429776 to m ^~3^~8^~3 gb|AAG07066.l|AE004787_6 (AE004787) probable

1430450 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~2263 sp|Q0191l|TETX_BACFR TETRACYCLINE RESISTANCE

PROTEIN (TRANSPOSON TN4351/TN4400) pir] |A39191

Contig9 from probable oxidoreductase (EC 1. - . - . - ) - SEQ ID n° 7123 PL-3029.1 1430613 to

Bacteroides fragilis gb | AAA27471.1 | (M37699) - — 1431926 tetracycline résistance protein [Transposon

Tn4351] SEQ ID n~2261 ref |NP_053071.1 | BfpE [Escherichia coli] pir| |S70972 bfpE protein - Escherichia coli

Contig9 from emb|CAA92332.l| (Z68186) BfpE [Escherichia coli] SEQ ID n° 7124 PL-3028.1 1432599 to m 513 gb|AAC44044.l| (U27184) BfpE [Escherichia coli]

1433696 dbj |BAA84844.l| (AB024946) BfpE [Escherichia coli] SEQ ID n~2260 ref |NP_052543.1] ATP-binding protein [Plasmid

Contig9 from ColIb-P9] dbj |BAA75182.l( (AB021078) ATP- SEQ ID n» 7125 PL-3027.1 1433703 to 453 binding protein [Plasmid ColIb-P9]

1435265 dbj |BAA77977.l| (AB027308) nucleotide-binding protein [Plasmid R64] SEQ ID n~2259

Contig9 from SEQ ID n° 7126 PL-3913.1 1435287 to m No Hits found

1435829 SEQ ID n~3078 Contig9 from gb|AAF14815.2 | (AF000001) PilO [Salmonella SEQ ID n° 7127 PL-3026.1 1435816 to m 403 typhi] gb|AAF81211.l|AF247502_6 (AF247502) PilO

1437108 [Salmonella dublin] SEQ ID n~2258 ref |NP_052546.l| lipoprotein [Plasmid ColIb-P9]

Contig9 from dbj |BAA75185.l| (AB021078) lipoprotein [Plasmid SEQ ID n° 7128 PL-3025.1 1437112 to m 543 ColIb-P9] dbj |BAA77974.l| (AB027308)

1438716 lipoprotein [Plasmid R64] SEQ ID n~2257

Contig9 from gb|AAF14812.2| (AF000001) PilL [Salmonella SEQ ID n° 7129 PL-6656.1 1438721 to m 47% typhi] gb|AAF81207.l|AF247502_2 (AF247502) PilL

1439062 [Salmonella dublin] #N/A

TABLEAU II

Contig9 from SEQ ID n° 7130 PL-6655.1 1439059 to m No Hits found

C

SEQ ID n° 7131 PL-3912.1 1439166 to m No Hits found 1439690 SEQ ID n~3077

Contig9 from gb|AAF81218.l|AF247502_13 (AF247502) PilV2 SEQ ID n° 7132 PL-3024.1 1439807 to m 353 [Salmonella dublin]

1440982 SEQ ID n~2256 sp|P31712|LEP4_ERWCA TYPE 4 PREPILIN-LIKΞ

PROTEINS LEADER PEPTIDE PROCESSING ENZYME

(PECTIC ENZYMES SECRETION PROTEIN OUTO)

Contig9 from

[INCLUDES: LEADER PEPTIDASE (PREPILIN SEQ ID n° 7133 PL-3023.1 1441022 to m 593

PEPTIDASE) ; N-METHYLTRANSFERASE ]

1441816 pir| |S32869 sécrétion protein outO - Erwinia carotovora subsp . carotovora emb | CAA 9656.11

(X70049) outO [Erwinia carotovora] SEQ ID n~2255 ref |NP_052541.l] typelV prepilin [Plasmid Collb-

Contig9 from

P9] dbj |BAA31138.l| (AB007463) type IV prepilin SEQ ID n° 7134 PL-3022.1 1441974 to m 413

[Plasmid CθlIb-P9] dbj |BAA75180. l| (AB021078)

1442546 typelV prepilin [Plasmid ColIb-P9] SEQ ID n~2254 sp]P38078 |VATA_CANTR VACUOLAR ATP SYNTHASE

CATALYTIC SUBUNIT A (V-ATPASE A SUBUNIT)

[CONTAINS: VMA1-DERIVED ENDONUCLEASE (VDΞ) (PI-

Contig9 from

CTR I ENDONUCLEASE)] pir||A46080 H+- SEQ ID n° 7135 PL-3021.1 1443224 to m 103 transporting ATPase (EC 3.6.1.35) chain A

1445011 precursor, vacuolar - yeast (Candida tropicalis) gb|AAB03895.1 ] (M64984) ORF

[Candida tropicalis] SEQ ID n~2253

Contig9 from emb|CAB77342.l| (AL160331) hypothetical protein SEQ ID n° 7136 PL-6651.1 1445697 to p 34% SCD8A.21c [Streptomyces coelicolor

1446146 A3 (2)] #N/A Contig9 from emb|CAB77347.l| (AL160331) hypothetical protein SEQ ID n° 7137 PL-3020.1 1446161 to p 31% SCD8A.26C [Streptomyces coelicolor

1447225 A3 (2)] SEQ ID n~2252

TABLEAU II

Contig9 from emb|CAB77347.l| (AL160331) hypothetical protein

- SEQ ID n° 7138 PL-3019.1 1447237 to 223 SCD8A.26c [Streptomyces coelicolor

1448628 A3 (2) ] SEQ ID n~2250

Contig9 from emb|CAB77347.l| (AL160331) hypothetical protein

SEQ ID n° 7139 PL-3018.1 1448677 to 353 SCD8A.26c [Streptomyces coelicolor

1449861_ A3 (2)] SEQ ID n~2249

Contig9 from

SEQ ID n^» 7140 PL-3910.1 1449875 to No Hits found

1450333 SEQ ID n~3076

Contig9 from

SEQ ID n° 7141 PL-3017.1 145θ 96^"to^" No Hits found

1451179 #N/A

Contig9 from emb(CAB77340.l| (AL160331) hypothetical protein

SEQ ID n° 7142 PL-3016.1 1451176 to 31% SCD8A.19C [Streptomyces coelicolor

1452777 A3 (2)] SEQ ID n~2248

Contig9 from emb | CAB77339. l | (AL160331) hypothetical protein

SEQ ID n° 7143 PL-3015.1 1452790 to p 243 SCD8A.18C [Streptomyces coelicolor

1453509 A3 (2 ) ] SEQ ID n~2247

Contig9 from

SEQ ID n° 7144 PL-6648.1 1453506 to No Hits found

1453922 #N/A

Contig9 from

SEQ ID n° 7145 PL-3014.1 1453966 to No Hits found

1456683 SEQ ID n~2246

Contig9 from

SEQ ID n° 7146 PL-3013.2 1456676 to No Hits found

1459582 #N/A ref |NP_050293.l| fiber protein [fowl adenovirus

Contig9 from

8] gb|AAC71676.l| (AF021254) fibre homolog

SEQ ID n° 7147 PL-3012.1 1459770 to 213

[fowl adenovirus 8] gb|AAD50350. l[AF083975_17

1461074

(AF083975) fiber protein [fowl adenovirus 8] SEQ ID n~2244

Contig9 from

SEQ ID n° 7148 PL-3011.1 1461138 to No Hits found

1462793 SEQ ID n~2243

TABLEAU II

Contig9 from emb|CAB77353.l| (AL160331) putative AAA family SEQ ID n° 7149 PL-3010.2 1462803 to 423 ATPase [Streptomyces coelicolor 1464887 A3 (2)] SEQ ID n~2242

Contig9 from emb|CAB77354.l| (AL160331) hypothetical protein SEQ ID n° 7150 PL-2586.2 1464912 to 233 SCD8A.33c (fragment) [Streptomyces 1465814 coelicolor A3 (2) ] SEQ ID n~£778

Contig9 from SEQ ID n° 7151 PL-3908.2 1465916 to No Hits found

1466398 #N/A Contig9 from SEQ ïrT n 7152 PL-2585.2 1466737 to No Hits found

1467579 #N/A Contig9 from ref |NP_065 79.1 | SepC [Serratia entomophila] SEQ ID n° 7153 PL-2584.1 1467699 to 413 gb|AAG09644.l| (AF135182) SepC [Serratia

1468721 entomophila] SEQ ID n~î776 Contig9 from gb|AAF81206.l|AF247502_l (AF247502) Ytl2 SEQ ID n° 7154 PL-2583.1 1469215 to 663 [Salmonella dublin]

1470237 SEQ ID n~1775 ref |NP_047874.l| putative transposase [Yersinia pestis] pir| |T14989 probable transposase -

Contig9 from

Yersinia pestis plasmid pMTl gb|AAC8273 .1 j

SEQ ID n° 7155 PL-6647.1 1470230 to 443

(AF074611) putative transposase [Yersinia

1470631 pestis] emb|CAB55253.l| (AL117211) hypothetical protein YPMT1.71 [Yersinia pestis] #N/A

Contig9 from

SEQ ID n° 7156 PL-6646.1 1470688 to m No Hits found

1470858 #N/A

Contig9 from

SEQ ID n° 7157 PL-6645.1 1471265 to No Hits found

1471714 #N/A

Contigθ from emb|CAB77347.l| (AL160331) hypothetical protein

SEQ ID n° 7158 PL-2582.1 1471768 to 29% SCD8A.26c [Streptomyces coelicolor

1472844 A3 (2) ] SEQ ID n-î.774

Contig9 from emb|CAB77347.l| (AL160331) hypothetical protein

SEQ ID n° 7159 PL-2581.1 1472856 to 203 SCD8A.26c [Streptomyces coelicolor

1474340 A3 (2) ] SEQ ID n~£773

TABLEAU II

Contig9 from emb|CAB77347.l| (AL160331) hypothetical protein

SEQ ID n° 7160 PL-2580.1 1474389 to 33% SCD8A.26c [Streptomyces coelicolor 1475594 A3 (2)] SEQ ID n-î.772

Contig9 from

SEQ ID n° 7161 PL-3906.1 1475608 to No Hits found

1476066 SEQ ID n~3073

Contig9 from

SEQ ID n° 7162 PL-6642.1 1476063 to No Hits found

1476242 #N/A

Contig9 from

SEQ ID n° 7163 PL-2579.1 1476229 to No Hits found

1476912 #N/A pir| |D82202 vgrG protein VC1416 [imported] -

Contig9 from

Vibrio cholerae (group 01 strain

SEQ ID n° 7164 PL-2578.1 1476909 to 133

N16961) gb|AAF94573.1| (AE004220) vgrG protein

1478510

[Vibrio cholerae] SEQ ID n~£770

Contig9 from emb| CAB7-7339.11 (AL160331) hypothetical protein

SEQ ID n° 7165 PL-3905.1 1478523 to 383 SCD8A.18c [Streptomyces coelicolor

1479014 A3 (2)] SEQ ID n~3072

Contig9 from

SEQ ID n° 7166 PL-6639.1 1479011 to No Hits found

1479427 #N/A

Contig9 from

SEQ ID n° 7167 PL-2577.1 1479524 to No Hits found

1482226 SEQ ID n~î769

Contig9 from

SEQ ID n° 7168 PL-2576.1 1482223 to No Hits found

1485129 SEQ ID n~î768

Contig9 from pir| (JQ1866 hypothetical 87.1K protein - bovine

SEQ ID n° 7169 PL-2575.2 1485331 to 273 adenovirus 3

1486281 #N/A

Contig9 from dbj |BAB06239.1] (AP001515) transposase related

SEQ ID n° 7170 PL-2574.1 1486331 to 21% protein (20) [Bacillus halodurans]

1487356 SEQ ID n~1766

TABLEAU II

ref |NP__065040.11 AMV258 [Amsacta moorei

Contig9 from entomopoxvirus] gb |AAG02964.l|AF250284_258

SEQ ID n° 7171 PL-2573.1 1487535 to 12%

(AF250284) AMV258 [Amsacta moorei

1489097 ento opoxvirus] SEQ ID n~î765

Contig9 from emb|CAB77353.l| (AL160331) putative AAA family

SEQ ID n° 7172 PL-2572.1 1489107 to 22% ATPase [Streptomyces coelicolor

1491173 A3 (2)1 SEQ ID n~1764

Contig9 from

SEQ ID n° 7173 PL-2571.1 1491198 to No Hits found

1492100 SEQ ID n-î.763

Contig9 from

SEQ ID n° 7174 PL-2570.1 1492181 to p No Hits found

1493110 SEQ ID n~2762

Contig9 from

SEQ ID n° 7175 PL-2569.1 1493302 to No Hits found

1494249 SEQ ID n-2.760

Contig9 from emb|CAB77342.l| (AL160331) hypothetical protein

SEQ ID n° 7176 PL-6634.1 1495180 to 353 SCD8A.21C [Streptomyces coelicolor

1495629 A3 (2)] #N/A

Contig9 from emb|CAB77347.l] (AL160331) hypothetical protein

SEQ ID n° 7177 PL-2568.1 1495682 to 28% SCD8A.26c [Streptomyces coelicolor

1496887 A3 (2)] SEQ ID n~î759

Contig9 from emb|CAB77347.l| (AL160331) hypothetical protein

SEQ ID n° 7178 PL-2567.1 1496899 to 223 SCD8A.26c [Streptomyces coelicolor

1498284 A3 (2)] SEQ ID n~1758

Contig9 from emb|CAB77347.l| (AL160331) hypothetical protein

SEQ ID n° 7179 PL-2566.1 1498340 to 33% SCD8A.26C [Streptomyces coelicolor

1499515 A3 (2)] SEQ ID n~i757

Contig9 from

SEQ ID n° 7180 PL-3903.1 1499551 to No Hits found

1500009 SEQ ID n~3071

Contig9 from

SEQ ID n° 7181 PL-6631.1 1500006 to No Hits found

1500185 #N/A

TABLEAU II

Contig9 from

SEQ ID n° 7182 PL-2565.1 1500172 to No Hits found

1500855 #N/A

Contig9 from emb|CAB77340. l| (AL160331) hypothetical protein

SEQ ID n" 7183 PL-2564.1 1500852 to 3E SCD8A.19c [Streptomyces coelicolor

1502453 A3 (2)] SEQ ID n~î756

Contig9 from emb CAB77339.l| (AL160331) hypothetical protein ⁼

SEQ ID n° 7184 PL-3902.1 1502466 to 423 SCD8A.18c [Streptomyces coelicolor

1502912 A3 (2)] SEQ ID n~3070

Contig9 from

SEQ ID n° 7185- PL-6630.1 1502909 to No Hits found

1503325 #N/A

Contig9 from

SEQ ID n° 7186 PL-2563.1 1503402 to No Hits found

1506104 SEQ ID n~î755

Contig9 from

SEQ ID n^» 7187 PL-2562.1 1506097 to No Hits found

1508976 SEQ ID n-î754

Contig9 from sp|P33666|YDBA_ECOLI HYPOTHETICAL 205.9 KDA

SEQ ID n° 7188 PL-2561.1 1509119 to 3? PROTEIN IN PAAY-ACPD INTERGENIC REGION

1510150 SEQ ID n~î753

Contig9 from

SEQ ID n° 7189 PL-2560.1 1510207 to No Hits found

1511886 SEQ ID n~î752

Contig9 from emb|CAB77353.l| (AL160331) putative AAA family

SEQ ID n° 7190 PL-2559.1 1511896 to 233 ATPase [Streptomyces coelicolor

1513980 A3 (2)] SEQ ID n~S750

Contigs from

SEQ ID n° 7191 PL-2558.1 1514005 to No Hits found

1514697 SEQ ID n~î749

Contig9 from

SEQ ID n° 7192 PL-6628.1 1514796 to No Hits found

1515032 #N/A

Contig9 from

SEQ ID n° 7193 PL-2557.1 1515235 to No Hits found

1516245 SEQ ID n~î748

TABLEAU II

Contig9 from

SEQ ID n° 7194 PL-2556.1 1516319 to No Hits found

1517293 SEQ ID n~1747

Contig9 from ref |NP_052862. l| hypothetical protein [Coxiella

SEQ ID n° 7195 PL-6627.1 1517483 to 423 burnetii] gb(AAD3349 . l| F131076_20 (AF131076)

1517620 hypothetical protein [Coxiella burnetii] #N/A ref |NP_073263.r|^""ôrf39 [salmonella enterica

Contig9 from serovar Choleraesuis] dbj |BAB20546.l|

SEQ ID n° 7196 PL-2555.1 1517721 to 77%

(AB040415) orf39 [Salmonella enterica serovar

1518647

Choleraesuis] SEQ ID n-ï746

Contig9 from

SEQ ID n° 7197 PL-6626.1 1518730 to No Hits found

1518831 #N/A

Contig9 from

SEQ ID n° 7198 PL- 6625.1 1519396 to No Hits found

1519845 #N/A

Contig9 from emb|CAB77347.l| (AL160331) hypothetical protein

SEQ ID n° 7199 PL-2554.1 1519899 to 28% SCD8A.26c [Streptomyces coelicolor

1520981 A3 (2)] SΞQ ID n~i745

Contig9 from emb| CAB77347.l| (AL160331) hypothetical protein

SEQ ID n° 7200 PL-2553.1 1520993 to 21% SCD8A.26C [Streptomyces coelicolor

1522426 A3 (2)] SΞQ ID n~î744

Contig9 from emb|CAB77347.l| (AL160331) hypothetical protein

SEQ ID n° 7201 PL-2552.1 1522474 to 313 SCD8A.26C [Streptomyces coelicolor

1523709 A3 (2) ] SΞQ ID n~£743

Contig9 from

SEQ ID n° 7202 PL-3900.1 1523723 to No Hits found

1524181 SΞQ ID n~3069

Contig9 from

SEQ ID n° 7203 PL-6624.1 1524160 to No Hits found

1524357 #N/A

Contig9 from

SEQ ID n° 7204 PL-2551.1 1524344 to No Hits found

1525027 SΞQ ID n~î742

TABLEAU II

pir| |D82202 vgrG protein VC1416 [imported] -

Contig9 from

Vibrio cholerae (group Ol strain

SEQ ID n° 7205 PL-2550.1 1525090 to 12%

N16961) gb|AAF94573.l| (AE004220) vgrG protein

1526625

[Vibrio cholerae] SEQ ID n~3L741

Contig9 from emb|CAB77339.l| (AL160331) hypothetical protein

SEQ ID n° 7206 PL-3899.1 1526638 to 383 SCD8A.18C [Streptomyces coelicolor

1527129 A3 (2)] ~ SEQ ID n~3066

Contig9 from

SEQ ID n° 7207 PL-6622.1 1527126 to No Hits found

1527542 #N/A

Contig9 from

SEQ ID n° 7208 PL-2549.1 1527585 to No Hits found

1530293 SEQ ID n-î.739

Contig9 from

SΞQ ID n° 7209 PL-2548.1 1530290 to p No Hits found

1533643 SEQ ID n-î.738

Contig9 from pir] |JQ1866 hypothetical 87.1K protein - bovine

SEQ ID n° 7210 PL-2547.1 1533753 to 233 adenovirus 3

1534970 SEQ ID n~£737

Contigs from

SEQ ID n° 7211 PL-2545.2 1535034 to No Hits found

1536998 SEQ ID n~î735

Contig9 from emb|CAB77353.l[ (AL160331) putative AAA family

SEQ ID n° 7212 PL-2851.1 1537008 to 243 ATPase [Streptomyces coelicolor

1539107 A3 (2)] SEQ ID n~2066

Contig9 from

SEQ ID n° 7213 PL-2850.1 1539131 to p No Hits found

1540033 SEQ ID n~2065

Contig9 from sp | Q47279 | HRPN_ΞRWCA HARPIN (HARPIN-ECC)

SEQ ID n° 7214 PL-2849.1 1540138 to 173 gb|AAB49733. l| (L78834) putative [Pectobacterium

1541124 carotovorum] SEQ ID n~2063

Contig9 from gb]AAA96022.1] (U38815) halovibrin [Vibrio

SEQ ID n° 7215 PL-2848.1 1541592 to m 553 fischeri] gb| AAG42286.1 | AF206719_1 (AF206719)

1542269 HvnA [Vibrio fischeri] SEQ ID n~2062

TABLEAU II

pir[ |G83406 conserved hypothetical protein

Contig9 from PA1914 [imported] - Pseudomonas SEQ ID n° 7216 PL-2847.1 1542148 to P 473 aeruginosa (strain PAOl)

T543035 gb | AAGÔ53Ô2^|AE004617_6 (AE004617) conserved hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2061

Contig9 from SEQ ID n° 7217 PL-2846.1 Ï543554 to No Hits found

1544351 SEQ ID n~2060 Contig9 from gb|AAF97407.l| (AY004319) photopexin A SEQ ID n° 7218 PL-6620.1 1544413 to P 353 [Photorhabdus luminescens]

1544673 #N/A Contig9 from gb|AAC26596.l| (U83995) putative protease SEQ ID n° 7219 PL-2845.1 1544661 to P 59% [Porphyromonas gingivalis]

1545545 SEQ ID n~2059 Contig9 from gb|AAF97407.l| (AY004319) photopexin A SEQ ID n° 7220 PL-2844.1 1545596 to 68% [Photorhabdus luminescens]

1546453 SEQ ID n~2058 ref |NP_073263.l| orf39 [Salmonella enterica

Contig9 from serovar Choleraesuis] dbj [BAB20546.l| SEQ ID n° 7221 PL-6619.1 1546575 to 48% (AB040415) orf39 [Salmonella enterica serovar

1546784

Choleraesuis] #N/A ref |NP_073263. l| orf39 [Salmonella enterica

Contig9 from serovar Choleraesuis] dbj |BAB20546.1] SEQ ID n° 7222 PL-2843.1 1546847 to m 76%

(AB040415) orf39 [Salmonella enterica serovar

1547809

Choleraesuis] SEQ ID n~2057

Contig9 from sp|P46147|YEFM_ECOLI HYPOTHETICAL 9.3 KD PROTEIN SEQ ID n° 7223 PL-6618.1 1547956 to m 56% IN SBCB-HISL INTERGENIC REGION

1548195 #N/A Contig9 from SEQ ID n° 7224 PL-2842.1 1548439 to No Hits found

1549059 SEQ ID n-2056 Contig9 from SEQ ID n° 7225 PL-2841.1 1549098 to m No Hits found

1549781 SEQ ID n~2055

TABLEAU II

sp|P22523 |MUKB_ΞCOLI CELL DIVISION PROTEIN MUKB pir] |C64832 cell division protein mukB -

Escherichia coli (strain K-12, substrain

Contig9 from.

MG1655) dbj |BAA35670.1|^~~TD9CT730T MukB protein

SEQ ID n° 7226 PL-2840.1 1550089 to m 883

[Escherichia coli] gb| AAC74010.l| (AE000194)

1554537 kinesin-like cell division protein involved in chromosome pΕSτTitTiôning ^{^}[Escherichia coli K12] SEQ ID n~2054

Contig9 from pir||S439l2 kicA protein - Escherichia coli SEQ ID n° 7227 PL-2839.1 1554534 to m 883 dbj |BAA3566S.l| (D90730) MukE protein

1555229 [Escherichia coli] SEQ ID n~2052 sp|P36567|MUKF_ECOLI MUKF PROTEIN (KILLING

FACTOR KICB) pir| |S43911 mukF protein -

Escherichia coli dbj |BAA05457. l| (D26440) MukF

Contig9 from

[Escherichia coli] dbj |BAA35668.1] (D90730) SEQ ID n° 7228 PL-2838.1 1555237 to m 883

MukF protein (killing factor KicB) . [Escherichia

1556559 coli] gb|AAC74008.l| (AE000194) mukF protein

(killing factor KICB) [Escherichia coli

K12] SEQ ID n-2051

Contig9 from gb|AAG55406.l|AE005282_l (AE005282) S- SEQ ID n° 7229 PL-2837.1 1556570 to m 733 adenosylmethionine-dépendent methyltransferase

1557349 [Escherichia coli 0157.-H7] SEQ ID n~2050 sp|P36565|YCBC_ECOLI HYPOTHETICAL 28.7 KDA

PROTEIN IN KDSB-MUKF INTERGENIC REGION pir] |G64831 probable membrane protein ycbC -

Escherichia coli gb | AAC74006. l| (AE000194) orf,

Contig9 from hypothetical protein [Escherichia coli K12] SEQ ID n° 7230 PL-2836.1 1557628 to p 703 dbj |BAA35666.l[ (D90730) Hypothetical protein in

1558467 kdsB-mukF intergenic région .

[Escherichia coli] gb | AAG55405. l| AE005281__8

(AEO 05 81) orf, hypothetical protein

[Escherichia coli 0157 :H7] SEQ ID n~2049

TABLEAU II

s | P04951 | DSB_ECOLI 3 -DEOXY-MANNO-OCTULOSONATE CYTIDYLYLTRANSFERASE (CMP-KDO _SYNTHETASE) (CMP-2- ETO-3-DEOXYOCTULOSONIC ACID

SYNTHETASE) (CKS) pir| ]A26322 3-deoxy-manno- octulosonate cytidylyltransferase (EC 2.7.7.38) •

Contig9 from Escherichia coli gb| AAA83877.l| (J02614) CMP- SEQ ID n°-7-2-3-l—-PL—2-8-35.1 1558696 to m 813 KDO synthetase [Escherichia coli]

1559445 dbj |BAA35664.l| (D90730) 3-deoxy-manno- octulosonate cytidylyltransferase (EC 2.7.7.38) [Escherichia coli] gb|AAC74004.l| (AEO00193) CTP:CMP-3-deoxy-D-manno- ctulosonate transferase [Escherichia coli K12] SEQ ID n~2048 sp]P75844|YCAR_ECOLI PROTEIN YCAR pir||D64831 ycaR protein - Escherichia coli gb| AAC74003.1 |

Contig9 from (AE000193) orf, hypothetical protein SEQ ID n° 7232 PL-6612.1 1559449 to 743 [Escherichia coli K12] dbj |BAA35663.1 | (D90730)

1559628 ORF_ID:o218#3 [Escherichia coli] gb|AAG55402.l|AE005281_5 (AE005281) orf, hypothetical protein [Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAB40823.l| (U82598) cold shock-like protein

SEQ ID n° 7233 PL-6611.1 1560007 to m 593 [Escherichia coli]

1560249 #N/A

Contig9 from gb|AAG55400.l|AE005281_3 (AE005281) putative EC

SEQ ID n° 7234 PL-2834.1 1560804 to 693 1.2 enzyme [Escherichia coli 0157 :H7]

1561799 SEQ ID n~2047

TABLEAU II

sp|P27299|MSBA_ECOLI PROBABLE TRANSPORT ATP- BINDING PROTEIN MSBA pir[ [S27998 probable ABC- type transport protein msbA - Escherichia coli emb|CAA77839.l| (Z11796) member of ATP-dependent transport family, very similar to mdr proteins and hemolysin B, export protein

Contig9—from-

SEQ ID n° 7235 PL-2832.2 1561796 to m 89%

MsbA protein. [Escherichia coli] gb | AAC74000. l|

1563541 (AE000193) ATP-binding transport protein; multicopy suppressor of htrB

[Ξscherichia^~côTi^~K12] gb |AAG55399.1 [ AE005281_2 (AE005281) ATP-binding transport protein; multicopy suppressor of htrB

[Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG55398.l|AE005281_l (AE005281) orf,

SEQ ID n° 7236 PL-2831.1 1563580 to m 56% hypothetical protein [Escherichia coli 0157 :H7]

1565907 SEQ ID n~2044

Contig9 from dbj |BAB06652.l| (AP001517) BH2933-unknown

SEQ ID n° 7237 PL-2830.1 1566816 to p 39% [Bacillus halodurans]

1567628 SEQ ID n~2043

Contig9 from dbj |BAB05889.l[ (AP001514) BH2170-unknown

SΞQ ID n° 7238 PL-2829.1 1567633 to p 46% conserved protein [Bacillus halodurans]

1568268 SEQ ID n~2041

Contig9 from

SEQ ID n° 7239 PL-6606.1 1568779 to p No Hits found

1568937 #N/A

Contig9 from

SEQ ID n° 7240 PL-2828.1 1569001 to p No Hits found

1569900 SEQ ID n~2040

Contig9 from

SEQ ID n° 7241 PL-6605.1 1570170 to m No Hits found

1570409 #N/A

TABLEAU II

sp|P23303 |IHFB_3ERMA INTEGRATION HOST FACTOR

Contig9 from BETA-SUBUNIT (IHF-BETA) pir] |B38173 intégration SEQ ID n° 7242 PL-6603.1 1570864 to m 893 host factor beta chain - Serratia marcescens

1571148 gb|AAA26557.l| (M62643) intégration host factor beta-subunit [Serratia marcescens] #N/A sp|P02349 |RS1_EC0LI 30S RIBOSOMAL PROTEIN SI pir| |R3EC1 ribosomal protein SI ^~[validated] -

Escherichia coli dbj |BAA35655. l| (D90729) 30S

Contig9 from ribosomal protein SI. [Escherichia coli] SEQ ID n° 7243 PL-2827.1 1571214 to m 96% gb|AAC73997.l| (AEO00193) 3OS ribosomal subunit

1572887 protein SI [Escherichia coli K12] gb|AAG55396.l|AE005280_7 (AE005280) 30S ribosomal subunit protein SI [Escherichia coli

0157:H7] SEQ ID n~203 sp|P23863|KCY_ECOLI CYTIDYLATE KINASE (CK)

(CYTIDINE MONOPHOSPHATE KINASE) (CMP KINASE)

(MSSA PROTEIN) (P25) pir| |E64830 cytidylate kinase (EC 2.7.4.14) [validated] - Escherichia coli pdb|2CMK|A Chain A, Cytidine Monophosphate

Kinase In Complex With Cytidine-Di-

Phosphate dbj ]BAA35645.1 | (D90728) Cytidylate kinase (EC 2.7.4.14) (ck) (cytidine

Contig9 from monophosphate kinase) (CMP kinase) (MssA

SEQ ID n° 7244 PL-2825.1 1573069 to 86% protein) (p25) . [Escherichia coli]

1573752 dbj |BAA35654.l| (D90729) Cytidylate kinase (EC

2.7.4.14) (ck) (cytidine monophosphate kinase) (CMP kinase) (MssA protein) (p25) . [Escherichia coli] gb|AAC73996.l| (AE000193) cytidylate kinase

[Escherichia coli K12] gb|AAG55395.l| AE005280_6

(AE005280) cytidylate kinase [Escherichia coli

0157 : H7] SEQ ID n~2038

TABLEAU II

sp|P19688|AROA_YEREN 3 -PHOSPHOSHIKIMATE 1-

CARBOXYVINYLTRANSFERASE (5-

ENOLPYRUVYLSHIKIMATE-3 -PHOSPHATE SYNTHASE) (EPSP_^

Contig9 from SYNTHASE) (EPSPS) pir| |XUEBY 3-phosphoshikimate SΞQ ID n° 7245 PL-2824.1 1574057 to m 843 1-carboxyvinyltransferase (EC 2.5.1.19)

1575343 [validated] - Yersinia enterocolitica gb|AAA27666.l| (M32213) 5-enolpyruvylshikimate 3- phosphate synthase (aroA) [Yersinia enterocolitica] SEQ ID n~2037 s | P19689 | SERC_YEREN PHOSPHOSERINE

^""AMINOTRANSFERASE (PSAT) pir| [XNΞBPY

Contig9 from phosphoserine transaminase (EC 2.6.1.52) - SEQ ID n° 7246 PL-2823.1 1575593 to m 88%

Yersinia enterocolitica gb|AAA27665.l| (M32213)

1576681

3-phosphoserine aminotransferase (serC)

[Yersinia enterocolitica] SEQ ID n~2036 pir| |G70582 hypothetical protein Rv0919 -

Contig9 from

Mycobacterium tuberculosis (strain SEQ ID n° 7247 PL-3897.1 1576853 to m 41%

H37RV) emb|CAB0850l.l[ (Z95210) hypothetical

1577356 protein Rv0919 [Mycobacterium tuberculosis] SEQ ID n~3065 sp[P43995|Y420_HAΞIN HYPOTHETICAL PROTEIN HI0420 pir| |D64007 hypothetical protein HI0420 -

Contig9 from

Haemophilus influenzae (strain Rd SEQ ID n° 7248 PL-6600.1 1577353 to m 58%

KW20) gb|AAC22082.l| (U32725) H. influenzae

1577628 predicted coding région HI0420

[Haemophilus influenzae Rd] #N/A

Contig9 from gb]AAG58088.l|AE005526_l (AE005526) periplasmic SEQ ID n° 7249 PL-2822.1 1577798 to m 82% L-asparaginase II [Escherichia coli 0157 :H7]

1578841 SEQ ID n~2035 Contigs from sp | 75838 | CAO_ECOLI HYPOTHETICAL 65.7 KD SEQ ID n° 7250 PL-2821.1 1578971 to p 86% PROTEIN IN FOCA-SERC INTERGENIC REGION

1580743 SEQ ID n~2034

TABLEAU II

sp|P2150l]FOCA_ECOLI PROBABLE FORMATE

TRANSPORTER 1 (FORMATE CHANNEL 1) pir| [A32305 probable formate transport protein - Escherichia coli dbj |BAA35639.l| (D90728) Probable formate

Contig9 from transporter [Escherichia coli] dbj [BAA35648.1 | SEQ ID n° 7251 PL-2820.1 1581063_^to_ 813 (D90729) Probable formate transporter

1581920^' [Escherichia colil ^~1P>| AÂC73990.1 | (AE000192) probable formate transporter (formate channel 1)

[Escherichia coli K12] gb |AAG55389.1 |AE005279_9

(AE005279) probable formate transporter (formate channel 1) [Escherichia coli 0157:H7] SEQ ID n~2033^~ sp|P0S373 |PFLB_ΞCOLI FORMATE ACETYLTRANSFERASE 1

(PYRUVATE FORMATE-LYASE 1) pir[|S01788 formate

C-acetyltransferase (EC 2.3.1.54) 1 -

Contig9 from Escherichia coli emb|CAA30828.l| (X08035) SEQ ID n° 7252 PL-2819.1 1581976 to 943 pyruvate formate-lyase (AA 1-760) [Escherichia

1584258 coli] dbj |BAA35638.l| (D90728) Formate C- acetyltransferase (EC 2.3.1.54). [Escherichia coli] gb]AAC73989.1] (AE000192) formate acetyltransferase 1 [Escherichia coli K12] SEQ ID n~2031 sp|P09374|PFLA_ECOLI PYRUVATE FORMATE-LYASE 1

ACTIVATING ENZYME (PFL-ACTIVATING ENZYME) pir||S01789 pyruvate formate-lyase activating enzyme (EC 1.97.1.4), lyase 1- specific - Escherichia coli (strain K-12) emb|CAA30829.l| (X08035) pyruvate formate-lyase

Contig9 from activating enzyme (AA 1-246) SEQ ID n° 7253 PL-2818.1 1584332 to 803 [Escherichia coli] gb |AAC73988.1 | (AE000192)

1585072 pyruvate formate lyase activating enzyme 1

[Escherichia coli K12] dbj |BAA35637.l| (D90728) Pyruvate formate-lyase

1 activating enzyme (EC 1.97.1.4).

[Escherichia coli] gb|AAG55387.l]AE005279_7

(AE005279) pyruvate formate lyase activating enzyme 1 [Escherichia coli 0157 :H7] SEQ ID n~2030

TABLEAU II

Contig9 from gb|AAF81206.l|AF247502_l (AF247502) Ytl2 SEQ ID n° 7254 PL-2817.1 1585489 to m 713 [Salmonella dublin] 1586427 _SEQ ID n~202S

Contig9 from gb|AAG54517.l]AE005197_6 (AE005197) Z0248 gène SEQ ID n° 7255 PL-6598.1 1586905 to m 533 product [Escherichia coli 0157 :H7]

1587174 #N/A pir| |C81839 probable transposase for IS1655

NMA1481 [imported] - Neisseria meningitidis (group B strain MD58, group A

Contig9 from strain Z2491) emb| CAB84714.l| (AL162756) SEQ ID-n5- 7256 PL-2816.2 1587691 to p 60% - putative transposase for IS1655 [Neisseria

1588659 meningitidis Z2491] emb| CAB84719.1 |

(AL162756) putative transposase for IS1655

[Neisseria meningitidis Z2491] #N/A

Contig9 from SEQ ID n° 7257 PL-6597.1 1588842 to p No Hits found

1589165 #N/A Contig9 from SEQ ID n° 7258 PL-2600.2 1589204 to p No Hits found

1589776 SEQ ID n-1793 Contig9 from gb|AAG00942.l|AF272977_2 (AF272977) transposase SEQ ID n° 7259 PL-2601.1 1591689 to m 293 [Mycoplasma hyopneumoniae]

1593305 SEQ ID n~1794 pir||F83l05 hypothetical protein PA4317

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 7260 PL-2602.1 1593424 to p 393 (strain PAOl) gb| AAG07705.1 | AE004848_4

1594182 (AE004848) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~£795

TABLEAU II

sp|P09156|SYS_ECOLI SΞRYL-TRNA SYNTHETASE (SERINE--TRNA LIGASE) (SERRS) pir| |YSΞC Serine-- tRNA ligase (EC 6.1.1.11) - Escherichia coli

Contig9 from emb|CAA28673.l| (X05017) seryl-tRNA synthetase SEQ ID n° 7261 PL-2603.1 1594278 to m 903 [Escherichia coli] dbj |BAA35625.1 | (D90727)

1595567 Serine-tRNA ligase (EC 6.1.1.11) [Escherichia coli] gb^~|AAC73979.l| (AE000191) serine tRNA synthetase; also charges selenocyεtein tRNA with serine [Escherichia coli K12] SEQ ID n~£796

Contig9 from gb|AAG55379.l|AE005278_5 (AE005278) putative

SEQ ID n° 7262 PL-2604 .ï^{~ "} 1595799 to m 92% polynucléotide enzyme [Escherichia coli

1597142 0157:H7] SEQ ID n~1797

Contig9 from sp|P39178|LOLA_ΞCOLI OUTER-MEMBRANE LIPOPROTEINS

SEQ ID n° 7263 PL-2605 1 1597150 to 74% CARRIER PROTEIN PRECURSOR (P20)

1597761 SEQ ID n-î.798

Sp|P46889|FTSK_ECOLI CELL DIVISION PROTEIN FTSK pir| [A64828 cell division protein ftsK - Escherichia coli dbj |BAA35615.1 | (D90726) Cell

Contig9 from division protein FtsK. [Escherichia coli] SEQ ID n° 7264 PL-2606.1 1597980 to 573 dbj |BAA35622.l| (D90727) Cell division protein

1601414

FtsK. [Escherichia coli] gb| AAC73976. l|

(AE000191) cell division protein [Escherichia coli K12] SEQ ID n~£799

Contig9 from

SEQ ID n° 7265 PL-6593.1 1601389 to m No Hits found

1601523 #N/A

Contig9 from

SEQ ID n° 7266 PL-3895.1 1601545 to m 953 emb|CAA71443.l| (Y10417) lrp [Proteus mirabilis]

1602039 SEQ ID n~3063

Contig9 from

SEQ ID n° 7267 PL- 7215.1 1602172 to No Hits found

1602330 #N/A

TABLEAU II

sp|P09625|TRXB_ECOLI THIOREDOXIN REDUCTASE

(TRXR) pir] | RDΞCT thioredoxin reductase (NADPH)

(ΞC 1.6.4.5) JvalidatedL-

Escherichia coli gb | AAA24697.1 | (J03762) thioredoxin reductase [Escherichia coli] Contig9 from dbj |BAA35613.l| (D90726) Thioredoxin reductase

SEQ ID n° 7268 PL-2607.1 1602538 to 883 (NADPH) (EC 1.6.4.5) [Escherichia

1603497 coli] dbj |BAA35620.l| (D90727) Thioredoxin reductase (NADPH) (ΞC 1.6.4.5) [Escherichia coli] gb|AAC73974.l| (AE000190) thioredoxin reductase [Escherichia coli K12] gb]AAG55375.l|AE005278_l (AE005278) thioredoxin reductase [Escherichia coli 0157 :H7] SΞQ ID n~ï800 sp|Q52402 |AARD_PROST TRANSPORT ATP-BINDING

Contig9 from PROTEIN AARD pir| |S70900 ABC-type transport SEQ ID n° 7269 PL-2608.1 1603632 to 82% protein aarD - Providencia stuartii

1605401 gb|AAB18930.l| (U30383) AarD [Providencia stuartii] SEQ ID n~∑801 sp|P23886|CYDC_ECOLI TRANSPORT ATP-BINDING

PROTEIN CYDC pir| |B35888 ABC-type transport protein cydC - Escherichia coli gb| AAA03230.1]

Contig9 from (L10383) putative [Escherichia coli] SEQ ID n° 7270 PL-2609.1 1605404 to 773 dbj (BAA35611.l| (D90726) Probable transport

1607152 protein mdrH [Escherichia coli] gb| AAC73972.1 |

(AE000190) ATP-binding component of cytochrome- related transport [Escherichia coli

K12] SEQ ID n-î.802

TABLEAU II

sp | P23885 | LPTP_ECOLI LEUCYL/PHENYLALANYL-TRNA-

PROTEIN TRANSFERASE pir] |A36888 leucyl, phenylalanyl-tRNA- -protein transferase (EC

2.3.2.-) - Escherichia coli

Contig9 from gb|AAA03231.l| (L10383) Leu/Phe-tRNA-protein SEQ ID n° 7271 PL-2610.1 1607156 to 713 transferase [Escherichia coli] gb|AAC36910.l|

1607851 ^"(M63145) orf 2 [Escherichia coli] dbj |BAA35610.l| (D90726) Leucyltransferase (EC 2.3.2.6). [Escherichia coli] gb| AAC73971.l| (AE000190) leucyl, phenylalanyl-tRNA-protein transferase [Escherichia coli K121 SEQ ID n~ï804 sp|P02998(lFl_ECOLI TRANSLATION INITIATION

FACTOR IF-1 pir]]FIECl translation initiation factor IF-1 - Escherichia coli emb| CAA68446.l|

(Y00373) initiation factor IF1 (AA 1 -72)

[Escherichia coli] gb| AAA03232.l| (L10383) putative [Escherichia coli] dbj |BAA35602.l|

Contig9 from

(D90725) Translation initiation factor IF-1

SEQ ID n° 7272 PL-6591.1 1608008 to 983

[Escherichia coli] dbj |BAA35607.l| (D90726)

1608226

Translation initiation factor IF-1 [Escherichia coli] gb|AAC73970.l| (AE000190) protein chain initiation factor IF-1 [Escherichia coli

K12] gb|AAG55371.l|AE005277_12 (AE005277) protein chain initiation factor IF-1

[Escherichia coli 0157 :H7] #N/A sp|P15716]CLPA_ECOLI ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPA pir | | SUECCA endopeptidase Clp ATP-binding chain A - Escherichia coli dbj |BAA35601. l| (D90725) ATP-

Contig9 from dependent Clp protease ATP-binding subunit ClpA.

SEQ ID n° 7273 PL-2611.1 1608325 to 893 [Escherichia coli] gb|AAC73969.l| (AE000190)

1610602 ATP-binding component of serine protease [Escherichia coli K12] gb|AAG55264.l|AE005269_8 (AΞ005269) ATP-binding component of serine protease [Escherichia coli 0157 :H7] SΞQ ID n~1805

TABLEAU II

sp|P75832]YLJA_ECOLI PROTEIN YLJA pir||A64827 yljA protein - Escherichia coli gb| AC73968.l|

Contig9 from (AE000190) rf^_hypothetical protein

SEQ ID n° 7274 PL-6589.1 1610635 to m 77% [Ξscherichia coli K12] dbj |BAA35600.1 | (D90725) 1610955 0RF_ID: o2l3#6 [Escherichia coli] gb]AAG55263.l|AE005269_7 (AE005269) orf, hypothetical protëiή ^{^}[Escherichia coli 0157 :H7] #N/A

Sp|P24245|CSPD_ECOLI COLD SHOCK-LIKE PROTEIN

CSPD (CSP-D) pir| |H64826 cold shock protein homolog cspD - Escherichia coli dbj |BAA35599.1 ]

Contig9 from

(D90725) Cόld^~shbck-like protein CspD. SEQ ID n° 7275 PL-6588.1 1611298 to 603

[Escherichia coli] gb|AAC73967.1 | (AE000190)

1611519 cold shock protein [Escherichia coli K12] gb]AAG55262.l|AE005269_6 (AE005269) cold shock protein [Escherichia coli 0157 :H7] #N/A

Sp|P7583l|YBJZ_ECOLI HYPOTHETICAL ABC

TRANSPORTER ATP-BINDING PROTEIN YBJZ pir| |G64826 probable ABC transporter ybj -

Contig9 from Escherichia coli gb|AAC73966.l] (AE000189) SEQ ID n° 7276 PL-2612.2 1611600 to m 80% putative ATP-binding component of a transport

1613543 system [Escherichia coli K12] dbj |BAA35598.l| (D90725) ABC transporter probable ATP-binding subunit homolog

[Escherichia coli] SEQ ID n~1806

Contig9 from gb|AAG55260.1 | AE005269_4 (AE005269) putative SEQ ID n° 7277 PL-2613.1 1613543 to m 73% membrane protein [Escherichia coli 0157.-H7]

1614655 SEQ ID n~£807 sp|P75826|YBJE_EC0LI HYPOTHETICAL 34.4 KD

Contig9 from PROTEIN IN POXB-AQPZ INTERGENIC REGION SEQ ID n° 7278 PL-2614.1 1614976 to p 76% pir| |B64826 probable membrane protein ybjE -

1615875 Escherichia coli gb|AAC73961.l| (AE000189) putative surface protein [Escherichia coli K12] SΞQ ID n-î.808

TABLEAU II

sp|P30858(ARTP_ECOLI ARGININE TRANSPORT ATP- BINDING PROTEIN ARTP pir | |H64824 arginine transport protein artP - Escherichia coli dbj |BAA35578.l| (D90724) Periplasmic transport

Contig9 from system protein ArtP. [Escherichia ^{SEQ I}P-J^l0-_Z Z⁹ PL-2615.1 1616179 to 863 coli] gb|AAC73951.l| (AE000188) ATP-binding

1616907 component of 3rd arginine transport system

[Escherichia coli K12] gb(AAG55243.1 ]AE005267_8

(AE005267) ATP-binding component of 3rd arginine transport system [Escherichia coli

0157:H7] ^~ SEQ ID n~1809 sp | P30859 |ARTI_ΞCOLI ARGININE-BINDING

PERIPLASMIC PROTEIN 1 PRECURSOR pir| |G64824 arginine-binding periplasmic protein 1 precursor

Contig9 from

- Escherichia coli dbj |BAA35577.1 | (D90724) SEQ ID n° 7280 PL-2616.1 1616927 to 82%

Arginine binding protein arti [Escherichia coli]

1617661 gb|AAC73950. l| (AE000188) arginine 3rd transport system periplasmic binding protein

[Escherichia coli K12] SEQ ID n~£810 sp|P3086l|ARTQ_ECOLI ARGININE TRANSPORT SYSTEM

PERMEASE PROTEIN ARTQ pir| (F64824 arginine transport system permease protein artQ -

Contig9 from

Escherichia coli dbj |BAA35576.l| (D90724) SEQ ID n° 7281 PL-2617.1 1617676 to 843

Arginine transport System protein ArtQ.

1618392

[Escherichia coli] gb|AAC73949.l| (AE000188) arginine 3rd transport system permease protein

[Escherichia coli K12] SEQ ID n~2811

TABLEAU II

sp|P30862|ARTM_ECOLI ARGININE TRANSPORT SYSTEM PERMΞASE PROTEIN ARTM pir| (E64824 arginine transport system permease protein artM -

Escherichia coli dbj |BAA35575.1 | (D90724)

Contig9 from Arginine transport system protein ArtM. SEQ ID n° 7282 PL-2618.1 1618392 to 843 [Escherichia coli] gb|AAC73948.l| (AE000188)

1619060 arginine 3rd transport system permease protein

[Escherichia coli K12] gb| AAG55240.1 | AE005267_5

(AE005267) arginine 3rd transport system permease protein [Escherichia coli

0157 :H7] SEQ ID n-î.812 sp|P75817|YBJF_EC0LI HYPOTHETICAL RNA

METHYLTRANSFERASE IN POTI-ARTJ INTERGENIC REGION pir| |C64824 probable RNA methyltransferase ybjF •

Contig9 from

Escherichia coli gb|AAC73946. l| (AE000187) SEQ ID n° 7283 PL-2619.3 1619114 to m 773 putative enzyme [Escherichia coli K12]

1620247 dbj |BAA35573.1| (D90724) Hypothetical RNA methyltransferase HI0958 (EC 2.1.1.-).

[Escherichia coli] #N/A sp|P75815|YBσN_ECOLI HYPOTHΞTICAL 17.7 KDA

PROTEIN IN RIMK-POTF INTERGENIC REGION pir| |E64823 hypothetical protein ybjN -

Contig9 from

Escherichia coli gb ]AAC73940. l| (AE000187) SEQ ID n° 7284 PL-3894.2 1620272 to m 14 putative sensory transduction regulator

1620784

[Escherichia coli K12] dbj |BAA35564.l| (D90723) ORF_ID:θ210#ll

[Escherichia coli] #N/A

Contig9 from gb|AAG55226.l|AE005266_5 (AE005266) orf,

SEQ ID n° 7285 PL-6585.1 1620876 to m 393 hypothetical protein [Escherichia coli 0157 :H7]

1621178 #N/A pir| |G82236 glutaredoxin 1 VC1146 [imported] -

Contig9 from

Vibrio cholerae (group Ol strain SEQ ID n° 7286 PL-6583.1 1621369 to p 833

N16961) gb|AAF94305.l| (AE004194) glutaredoxin

1621629

1 [Vibrio cholerae] #N/A

TABLEAU II

Contig9 from

SΞQ ID n° 7287 PL-7214.1 1621862 to No Hits found

1622047 #N/A

ContigS from gb|AAG55217.l|AE005265_7 (AE005265) orf,

SEQ ID n° 7288 PL-2620.1 1622178 to 653 hypothetical protein [Escherichia coli 0157 :H7]

1622786 SEQ ID n~ï815 sp|P36559|SDAC_EC0LI SERINE TRANSPORTER pir||S45633 serine transport protein sdaC -

Escherichia coli gb | AAA50169.1 | (U01233) putative serine transporter [Escherichia coli]

Contig9 fro - gb|AAB40446. l|

putative serine SEQ ID n° 7289 PL-2621.1 1623693 to 87% transporter [Escherichia coli] gb|AAC75838.1 ]

1624991

(AEO00363) probable serine transporter

[Escherichia coli K12] gb| AAG57910.1 | AE005508_1

(AE005508) probable serine transporter

[Escherichia coli 0157 :H7] SEQ ID n~î816

Contig9 from

SEQ ID n° 7290 PL-2622.2 1625069 to m No Hits found

1625890 #N/A

Contig9 from gb[AAA27616.l| (M97630) crystalline inclusion

SEQ ID n° 7291 PL-6581.1 1626604 to p 81% protein type II [Xenorhabdus

1626918 luminescens] #N/A

Contigs from

SΞQ ID n° 7292 PL-6580.1 1628069 to p No Hits found

1628407 #N/A

Contig9 from

SEQ ID n° 7293 PL-2623.1 1628995 to p No Hits found

1629849 SEQ ID n~3L818

TABLEAU II

sp | 08506 | DACC_ECOLI PENICILLIN-BINDING PROTEIN

6 PRECURSOR (D-ALANYL-D-ALANINE

CARBOXYPEPTIDASE FRACTION C) (DD-PEPTIDASE)

(DD^CARBOXYPEPTIDASE) (PBP-6) pir] |G64821 serine-type D-Ala-D-Ala carboxypeptidase (ΞC

Contig9 from

3.4.16.4) dacC precursor - SEQ ID n° 7294—PL-=2624.2 1630066 to m 773

-^~ Escherichia coli dbj |BAA3554 .1 | (D90722)

1631268 Penicillin-binding protein 6 precursor. [Escherichia coli] gb |AAC73926.l| (AE000186) D- alanyl-D-alanine carboxypeptidase; penicillin- binding protein 6 [Escherichia coli

K12] #N/A pir||C83294 probable glutathione s-transferase

PA2813 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 7295 PL-2625.1 1631702 to 64% gb|AAG06201.l|AE004708_7 (AE004708) probable

1632322 glutathione S-transferase [Pseudomonas aeruginosa] SEQ ID n~£820 sp|P7637θ|YEEZ_ECOLI PROTEIN YΞEZ PRECURSOR

Contig9 from pir| |G64966 hypothetical protein b2016 - SEQ ID n° 7296 PL-2626.1 1632329 to 663 Escherichia coli gb|AAC75077.l| (AE000293)

1633156 putative enzyme of sugar metabolism [Escherichia coli K12] SΞQ ID n~i821 sp ( P10366 | HIS1_ΞC0LI ATP

PHOSPHORIBOSYLTRANSFERASE pir| | 156436 ATP phosphoribosyltransferase - Escherichia coli pir| |XREC ATP phosphoribosyltransferase (EC

2.4.2.17) - Escherichia coli emb| CAA45224.l|

Contig9 from (X63697) ATP-phosphoribosyl transferase

SEQ ID n° 7297 PL-2627.1 1633585 to 90% [Escherichia coli] gb| AAA19742.ι] (U02070) ATP

1634496 phosphoribosyltransferase [Escherichia coli] dbj |BAA15850.1| (D90840) ATP phosphoribosyltransferase (EC 2.4.2.17).

[Escherichia coli] gb] AC75080.l]

(AE000293) ATP phosphoribosyltransferase

[Escherichia coli K12] SΞQ ID n~£822

TABLEAU II

sp|P10370|HISX_SALTY HISTIDINOL DEHYDROGENASE

(HDH) pir| |DEEBHT histidmol dehydrogenase (EC

1.1.1.23) - Salmonella typhimurium emb[CAA31823.l| (X13464) hisD ORF (AA 1-434)

Contig9 from

[Salmonella typhimurium] gb ] AA88615.1 |

SEQ ID n° 7298 PL-2628.1 1634503 to 433

(J01804) hisfidinol dehydrogenase [Salmonella -16369-26 typhimurium] gΕr|AAA73023.ïj (M64753) hisfidinol dehydrogenase [unidentified cloning vector] gb|AAA73024.l[ (M64754) hisfidinol dehydrogenase

[unidentified cloning vector] SEQ ID n~î823 gb|AAG57σ r.l| AEO05427_9 (AE005427)

Contig9 from imidazoleglycerolphosphate dehydratase and

SEQ ID n° 7299 PL-2629.1 1636926 to 84% hisfidinol-phosphate phosphatase [Escherichia

1637993 coli 0157 :H7] SEQ ID n~î824 sp[P10375|HIS5_ECOLI AMIDOTRANSFERASE HISH pir| |XQECHH i idazole glycerol phosphate synthase (EC 2.4.2.-) chain hisH -

Escherichia coli emb | CAA31815. l| (X13462) hisH

ORF (AA 1-196) [Escherichia coli] dbj [BAA15854.1 | (D90840) Amidotransferase HisH

Contig9 from

(EC 2.4.2.-) [Escherichia coli] dbj |BAA15862.l| SEQ ID n° 7300 PL-2630.1 1637993 to 69%

(D90841) Amidotransferase HisH (EC 2.4.2.-)

1638598

[Escherichia coli] gb| AC75084.l| (AE000293) glutamine amidotransferase subunit of heterodimer with HisF = imidazole glycerol phosphate synthase holoenzyme

[Escherichia coli K12] dbj |BAA7774 .1 |

(AB008676) aminotransferase [Ξscherichia coli] SEQ ID n~î826 gb]AAG57083.l|AE005427_ll (AE005427) N-(5'-

Contig9 from phospho-L-ribosyl-formimino) -5-amino-l- (5' - SEQ ID n° 7301 PL-2631.1 1638604 to 773 phosphoribosyl) -4 -imidazolecarboxarrd.de isomerase

1639341

[Ξscherichia coli 0157 :H7] SEQ ID n~1827 sp|P10374|HIS6_SALTY HISF PROTEIN (CYCLASE)

Contig9 from pir| ]0YEBHF cyclase hisF - Salmonella SEQ ID n° 7302 PL-2632.1 1639323 to 893 typhimurium emb| CAA31828.1 | (X13464) hisF ORF

1640099

(AA 1-258) [Salmonella typhimurium] SEQ ID n~£828

TABLEAU II

dbj |BAA77739.l| (AB008676) phosphoribosyl-AMP cyclohydrolase [Escherichia coli]

Contig9 from gb|AAG57085.l|AE005427_13 (AΞ005427) SEQ-ID-n°~7303 PL-2633.1 16400S3 to -8-1% phosphoribosyl-amp cyclohydrolase ;

1640698 phosphoribosyl-ATP pyrophosphatase

[Escherichia coli 0157 :H7] SEQ ID n~î829

Contig9 from gb|AAG58733.1|AE005585_7 (AE005585) putative SEQ ID n» 7304 PL-2634.1 1640980 to m 793 oxidoreductase [Escherichia coli 0157 :H7]

1642131 SEQ ID n~£830 sp|P76238|YEAK_ECOLI HYPOTHETICAL 17.9 KD

PROTEIN IN GAPA-RND INTERGENIC REGION pir| |C64939 hypothetical protein bl787 -

Contig9 from

Escherichia coli (strain κ-12) gb|AAC74857.l] SEQ ID n° 7305 PL-3893.1 1642553 to 713

(AE000273) orf, hypothetical protein

1643044

[Escherichia coli K12] gb| AAG56776.1 | AE005402_^

(AE005402) orf, hypothetical protein

[Escherichia coli 0157 :H7] SEQ ID n~3061 sp|P54657|CADl_DICDI CALCIUM-DEPENDENT CELL

Contig9 from ADHESION MOLECULE-1 (DDCAD-1) (GP24) SEQ ID n° 7306 PL-2635.1 1643660 to 44% gb| AAC47135.l| (U49650) dictyostelium discoideum

1644280 calcium-dependent cell adhésion molecule-1 DdCAD-1 [Dictyostelium discoideum] SEQ ID n~î.B31 sp | P14062 | 6PGD_SALTY 6-PHOSPHOGLUCONATE

DEHYDROGENASE, DECARBOXYLATING pir||S04397 phosphogluconate dehydrogenase (decarboxylating)

Contig9 from (EC 1.1.1.44) - Salmonella SEQ ID n° 7307 PL-2636.1 1644930 to 833 typhimurium emb(CAA33677.l| (X15651) 6-

1646336 phosphogluconate dehydrogenase (AA 1-468)

[Salmonella enterica] gb |AAA27137. l|

(M64332) 6-phosphogluconate dehydrogenase

[Salmonella typhimurium] SEQ ID n~£832

Contig9 from s ] P76389 | YEGH_ECOLI HYPOTHETICAL 59.5 KDA SEQ ID n° 7308 PL-2637.1 1646582 to 833 PROTEIN IN WZA-ASMA INTERGENIC REGION

1648153 SEQ ID n~£833

TABLEAU II

Contig9 from gb|AAG57126.l|AE005432_7 (AE005432) suppressor SEQ ID n° 7309 PL-2638.1 1648644 to m 613 of ompF assembly mutants [Escherichia coli

1650476 _ 0157:H7] SEQ ID n-î.834

Contig9 from gb]AAG57Ï27.l|AE005432_8 (AE005432) 2'- SEQ ID n° 7310 PL-2639.1 1650535 to 793 deoxycytidine 5 ' -triphosphate deaminase

1651116 [Escherichia coli 0157 :H7] SEQ ID n~ï835 pir| |A64973 uridine kinase (EC 2.7.1.48) -

Escherichia coli gb |AAC75127.1 | (AE000296)

Contig9 from uridine/cytidine kinase [Ξscherichia coli K12] SEQ ID n° 7311 PL-2640.1 1651170 to m 78% gb]AAG57128.l|AΞ005432_9 (AE005432)

1651811 uridine/cytidine kinase [Escherichia coli ^~"

0157 :H7] SEQ ID n-î.837 pir| |H64978 probable ATPase mrp - Escherichia

Contig9 from coli gb|AAA60527.l| (U00007) mrp [Escherichia SEQ ID n° 7312 PL-2641.1 1652069 to m 853 coli] gb|AAC75174.l| (AΞ000300) putative ATPase

1653181 [Ξscherichia coli K12] prf | | 014253F ATPase

[Escherichia coli] SEQ ID n~ï838

Contig9 from gb|AAG57175.l|AE005437_10 (AΞ005437) methionine SEQ ID n° 7313 PL-2643.1 1653443 to 893 tRNA synthetase [Escherichia coli 0157 :H7]

1655470 SEQ ID n~î839 pir] |B83613 secreted protein Hep PA0263

[imported] - Pseudomonas aeruginosa

(strain PAOl) pir] [C83455 secreted protein Hep

PA1512 [imported] - Pseudomonas aeruginosa

(strain PAOl) pir| |G82987 secreted protein Hep

Contigθ from

PA5267 [imported] - Pseudomonas aeruginosa

SEQ ID n° 7314 PL-3892.1 1656211 to p 4É

(strain PAOl) gb|AAG0365 .l|AE004 64_5

1656519

(AE004464) secreted protein Hep [Pseudomonas aeruginosa] gb |AAG04901.l]AE004580_1 (AE004580) secreted protein Hep [Pseudomonas aeruginosa] gb|AAG08652.l|AE004939_4 (AEO04939) secreted protein Hep [Pseudomonas aeruginosa] SEQ ID n~3060

Contig9 from SEQ ID n° 7315 PL-6574.1 1656546 to m No Hits found

1656701 #N/A

TABLEAU II

Contig9 from

SEQ ID n° 7316 PL-2644.1 1656793 to m No Hits found

1657329 SEQ ID n~£840

Contig9 from gb|AAG57279.l|AE005446_7 (AE005446) orf,

SEQ ID n° 7317 PL-3891.1 1657613 to 523 hypothetical protein [Escherichia coli 0157 :H7]

1658050 SEQ ID n~3059 sp | 33373 | Y0HK_EC0LI-HYP0THETICAL 24.5 KD

PROTEIN IN PBPG-CDD INTERGENIC REGION

Contig9 from pir| |E64982 yohK protein - Escherichia coli SEQ ID n° 7318 PL-2645.1 1658053 to 843

(strain K-12) gb] AAC75203.1 | (AE000303)

1658748 putative seritonin ^"transporter [Escherichia coli

K12] SEQ ID n-î.841 sp|P13652|CDD_ECOLI CYTIDINE DEAMINASE (CYTIDINE

AMINOHYDROLASE) (CDA) pir] |F64982 cytidine deaminase (EC 3.5.4.5) - Ξscherichia coli pdb|lCTT| Cytidine Deaminase (Cda)

(E.C.3.5.4.5) Complexed ith 3,4-

Dihydrozebularine (Dhz) pdb|lAF2|A Chain A,

Crystal Structure Of Cytidine Deaminase

Complexed With uridine pdb|lALN|

Contig9 from Crystal Structure Of Cytidine Deaminase

SEQ ID n° 7319 PL-2646.1 1658890 to 623 Complexed With 3 -Deazacytidine

1659774 pdb]lCTϋ| Cytidine Deaminase (Cda)

(E.C.3.5.4.5) complexed With 3,4 Hydrated

Pyrimidine-2 -One Riboside (Zeb) gb| AAA23542.1 |

(M60916) cytidine deaminase [Ξscherichia coli] gb|AAA60533.l| (U00007) cytidine deaminase

[Escherichia coli] gb|AAC75204.1 | (AE000303) cytidine/deoxycytidine deaminase [Escherichia coli K12] prf | | 014253BU cytidine deaminase

[Escherichia coli] SEQ ID n-î.842

TABLEAU II

sp|P26616|MA01_ECOLI NAD-DEPENDENT MALIC ENZYME (NAD-ME) pir| |B64901 malate dehydrogenase

(oxaloacetate-decarboxylating) (EC

NAD-linked - Escherichia coli dbj ^' BAA15127.1|

Contig9 from (D90788) SfcA protein (fragment) [Escherichia

SEQ ID n° 7320 PL-2647.1 1660025 to 77% coli] dbj |BAA15136.l| (D90789) SfcA protein

1661722 (fragment). [[EEsscchheerriicchhiiaa ccoollii]] ddbbjj |BAA15146.1|

(D90790) SfcA protein (fragment) . [Escherichia coli] gb|AAC74552.l| (AE000245) NAD-linked malate dehydrogenase (malic enzyme)

[Escherichia coli K12] SEQ ID n~1843 sp|P33017|SANA_ECOLI SANA PROTEIN pir||G64982 sanA protein - Escherichia coli (strain K-12)

Contig9 from gb|AAC75205.l| (AE000303) vancomycin sensitivity SEQ ID n° 7321 PL-2648.1 1661989 to 803

[Escherichia coli K12]

1662729 gb|AAG57282.l|AE005446_10 (AE005446) vancomycin sensitivity [Escherichia coli 0157 :H7] SEQ ID n~ï844

Contig9 from gb|AAG57290.l|AE005447_5 (AE005447) Z3408 gène SΞQ ID n° 7322 PL-2649.1 1662701 to 623 product [Escherichia coli 0157:H7]

1663825 SΞQ ID n-î.845 sp|P2751l|GCHl_EC0LI GTP CYCLOHYDROLASE I (GTP-

CH-I) pir| |H64983 GTP cyclohydrolase I (EC

3.5.4.16) [validated] - Escherichia coli emb |CAA45365.1] (X63910) GTP cyclohydrolase i

Contig9 from [Escherichia coli] gb]AAA60535.l| (U00Q07) GTP SEQ ID n° 7323 PL-2650.1 1663871 to m 853 cyclohydrolase I [Escherichia coli]

1664530 gb|AAC75214.l| (AE000304) GTP cyclohydrolase I [Escherichia coli K12] gb| AAG57291.l| E005447_6

(AE005447) GTP cyclohydrolase I [Escherichia coli 0157:H7] prf | | 2014253AX GTP cyclohydrolase

I [Escherichia coli] SEQ ID n~£847 pir| |C83470 hypothetical protein PA1412

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 7324 PL-2651.1 1664724 to 55 (strain PAOl) gb|AAG04801. l|AE004570_9

1665896 (AΞ004570) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n-î.848

TABLEAU II

Contig9 from dbj |BAB06 10.l| (AP001515) 3-oxoacyl- (acyl-

SEQ ID n° 7325 PL-2652.1 1666396 to p 533 carrier protein) reductase [Bacillus

1667142 halodurans] SEQ ID n~î849

Contig9 from gb|AAG55200.l|AE005263_9 (AE005263)

SEQ ID n° 7326 PL-2653.1 1667364 to 773 molybdopterin biosynthesis [Ξscherichia coli

1668605 0157 :H7] SEQ ID n~î850 sp|P12282 |MOEB_ECOLI MOLYBDOPTERIN BIOSYNTHESIS

MOEB PROTEIN pιr| |B32352 molybdopterin biosynthesis protein moeB - Ξscherichia coli gb|AAA23580.l| (M21151) chlN protein

ContigS from [Ξscherichia coli] dbj |BAA35514.1 | (D90720) SEQ ID n° 7327 PL-2654.1 1668605 to 783 Molybdopterin biosynthesis MoeB protein.

1669357 [Escherichia coli] dbj |BAA35521.l|

(D90721) Molybdopterin biosynthesis MoeB protein. [Escherichia coli] gb|AAC73913.l| (AE000185) molybdopterin biosynthesis [Escherichia coli K12] SEQ ID n~£851 sp|P75790|YBIT_ΞCOLI HYPOTHETICAL ABC

TRANSPORTER ATP-BINDING PROTEIN YBIT pir| |D64819 probable ABC-type transport protein ybiT - Escherichia coli gb| AAC73907.l|

(AE000184) putative ATP-binding component of a

Contig9 from transport system [Escherichia coli SEQ ID n° 7328 PL-2655.3 1669456 to m 853 K12] dbj |BAA35501.1| (D90719) Hypothetical

1671051 protein HI0658 [Escherichia coli] dbj |BAA35508.l| (D90720) Hypothetical protein

HI0658 [Escherichia coli] gb|AAG55192.l|AE005263_l (AE005263) putative ATP binding component of a transport system

[Escherichia coli 0157 :H7] #N/A

Contig9 from

SEQ ID n° 7329 PL-3940.2 1672156 to No Hits found

1672566 #N/A

Contig9 from dbj |BAB06803.1] (AP001517) BH3084~unknown

SEQ ID n° 7330 PL-3183.2 1672885 to m 743 conserved protein [Bacillus halodurans]

1673448 #N/A

TABLEAU II

Contig9 from SEQ ID n° 7331 PL-6571.1 1674055 to No Hits found

1674141 #N/A pir| [Ξ64818 probable membrane protein ybiF -

Escherichia coli gb |AAC73900. l| (AE000183) putative transmembrane subunit [Escherichia coli

- Contig9 from K12] dbj |BAA35485.l| (D907185^{^}Hypothetical

SEQ ID n° 7332 PL-3182.1 1674128 to 773 protein 1 [Escherichia coli] db |BAA35495.l|

1675021 (D90719) Hypothetical protein 1 [Escherichia coli] gb|AAG55185.l|AE005262_5 (AE005262) putative transmembrane subunit [Escherichia coli

0157:H7] SEQ ID n~2431

Contig9 from pir| | 169619 pexB protein - Escherichia coli SEQ ID n° 7333 PL-6570.1 1675316 to 843 gb|AAA21855.l| (U04242) PexB [Escherichia coli]

1675663 #N/A pir| |H81436 phnA-like protein Cj 0185c [imported]

Contig9 from

- Campylobacter jejuni (strain NCTC SEQ ID n° 7334 PL-6569.1 1675955 to 65%

11168) emb|CAB72668.l| (AL139074) phnA-like

1676176 protein [Campylobacter jejuni] m/A

Contig9 from pir| |D70329 hypothetical protem aq_327 - SEQ ID n° 7335 PL-3181.1 1676581 to 373 Aquifex aeolicus gb |AAC06629.l| (AE000684)

1677276 putative protein [Acjuifex aeolicus] SEQ ID n~2430 pir| |D69790 probable halide peroxidase (EC

Contig9 from 1.11.1.-) ydjP - Bacillus subtilis SEQ ID n° 7336 PL-3180.1 1677341 to 383 dbj ]BAA22772.1 | (AB007638) peroxidase [Bacillus

1678279 subtilis] emb|CAB12447.l| (Z99107) similar to arylesterase [Bacillus subtilis] SEQ ID n~2429

Contig9 from gb|AAF13753.1 | AF117351_10 (AF117351) SEQ ID n° 7337 PL-3179.1 1678296 to 553 dihydrodipicolinate synthetase [Zymomonas

1679189 obilis] SEQ ID n~2427 ref |NP_061701.l[ hypothetical protein [Xylella fastidiosa] pir| |E82866 hypothetical protein

Contig9 from

XFa0046 [imported] - Xylella fastidiosa SEQ ID n° 7338 PL-6567.1 1679261 to 41%

(strain 9a5c) gb|AAF85614.l|AE003851_45

1679560

(AE003851) hypothetical protein [Xylella fastidiosa] #N/A

TABLEAU II

ref |NP__05836l . l | putative transposase

Contig9 from

[Salmonella typhi] gb | AAF69986. l| AF250878_147 SEQ ID n° 7339 PL-6566.1 1679668 to m 31%

(AF250878) putative transposase [Salmonella

- - 1680000 typhi] #N/A

Contig9 from gb|AAG54503.l|AE005196_l (AΞ005196) putative SEQ ID n° 7340 PL-3178.1 1680307 to p 85% aldose reductase (EC 1.1.1.21) [Escherichia

1681113 _ _{cQii Ό157}._H7J SEQ ID n~2426 pir| |B83480 probable oxidoreductase PA1334

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 7341 PL-3177.1 1681376 to p 81% (strain PAOl) gb] AAG04723. l| E004562_10

— 1682488 ^'(AEO 04562) probable oxidoreductase [Pseudomonas aeruginosa] SEQ ID n~2425

Contig9 from gb|AAG54504.l|AE005196_2 (AΞ005196) putative SEQ ID n° 7342 PL-3176.1 1682622 to m 82% transcriptional regulator LYSR-type

1683530 [Escherichia coli 0157 :H7] SEQ ID n~2424 Contig9 from gb|AAG55171.l|AΞ005261_l (AE005261) putative ATP- SEQ ID n° 7343 PL-3175.1 1683530 to m 76% dependent helicase [Escherichia coli

1685677 0157 :H7] SEQ ID n~2423 Contig9 from gb|AAG57635.l|AE005482_2 (AΞ005482) putative SEQ ID n° 7344 PL-3174.1 1686073 to p 58% thiosulfate sulfurtransferase [Escherichia coli

1686909 0157:H7] SEQ ID n~2422 ref |NP_052816.l[ pXOl-120 [Bacillus anthracis]

Contig9 from pir] ]H59105 hypothetical protein pXOl-120 - SEQ ID n° 7345 PL-3939.1 1687019 to p 59% Bacillus anthracis virulence plasmid

1687591 pXOl gb|AAD32424.l|AAD32424 (AF065404) pXOl-120

[Bacillus anthracis] SEQ ID n~3099

ContigS from db ]BABl6031.l| (AB030747) transposase SEQ ID n° 7346 PL-3938.1 1687708 to p 42% [Streptococcus pyogenes]

1688412 SEQ ID n~3098 Contig9 from emb|CAA70510.1 [ (Y09330) ferulic acid esterase A SEQ ID n° 7347 PL-1787.1 1689123 to p 20% [Aspergillus niger]

1690247 SEQ ID n~906 ContigS from emb|CAC15040.l| (AJ012575) triacylglycerol SEQ ID n° 7348 PL-1788.1 16S0842 to p 15% lipase [Candida ernobii]

1691960 SEQ ID n~907

TABLEAU II

Contig9 from SEQ ID n° 7349 PL-1789.1 1692331 to 183 gb|AAB07724.l| (U55867) Ipomoea nil Pn47p

1693461 SEQ ID n~908

Contig9 from SEQ ID n° 7350 PL-1790.1 1693870 to No Hits found

1694988 SEQ ID n~910

Contig9^~from SEQ ID n° 7351 PL-1791.1 1695297 to 64% emb(CAA40809.l( (X57583) mccB [Escherichia coli]

1696355 SEQ ID n~911 pir| (E64665 tetracycline résistance protein

Contig ^" rom tetA(P) homolog^"^^r_Helicobacter pylori ^" ~ SEQ ID n° 7352 PL-1792.1 1696382 to 433 (strain 26695) gb| AD08210.1 | (AE000622)

1697527 tetracycline résistance protein tetA(P) , putative [Helicobacter pylori 26695] SΞQ ID n~912 pir| |D69887 conserved hypothetical protein ynaD

Contig9 from Bacillus subtilis gb] AAB41084. l| (U66480) YnaD SEQ ID n° 7353 PL-3937.1 16975.09 to 41% [Bacillus subtilis] emb|CAB13636.l| (Z99113)

1698051 similar to hypothetical proteins [Bacillus subtilis] SΞQ ID n~309~ sp|P3337l|YOHI_ECOLI HYPOTHETICAL 35.2 KD PROTEIN IN PBPG-CDD INTERGENIC REGION pir| |C64982 hypothetical 35.2 kD protein in pbpG

Contig9 from cdd intergenic région - Escherichia

SEQ ID n° 7354 PL-1793.1 1698285 to m 91% coli (strain K-12) gb | AAA60503. l | (U00007) yohl

1699217 [Escherichia coli] gb ( AAC75201.1 | (AE000303) putative regulator protein [Escherichia coli

K12] prf | |2014253AN yohl gène [Escherichia coli] SEQ ID n~913

TABLEAU II

sp|P25888|RHLE_ECOLI PUTATIVE ATP-DEPENDΞNT RNA

HELICASE RHLE pir|]E64816 probable ATP- dependent RNA helicase rhlE - Escherichia coli gb[AAA53653.l| (L02123) ATP-dependent RNA

ContigS from helicase [Escherichia coli] db |BAA35463.l| SEQ ID n° 7355 PL-1794.1 1699221 to m 843 (D90717) Putative ATP-dependent RNA helicase

1700525 RhlE . [Escherichia coli] gb|AAC73884.l| (AE000182) putative ATP-dependent RNA helicase [Ξscherichia coli ^' K12] dbj |BAA35457.1| (D90716) Putative ATP-dependent RNA helicase RhlE. [Ξscherichia coli] SEQ ID n-914 pir| |D64816 probable transcription regulator ybiH - Escherichia coli gb| AAC73883.1 |

Contig9 from (AE000181) putative transcriptional regulator

SEQ ID n° 7356 PL-1795.1 1700803 to 633 [Escherichia coli K12]

1701495 gb|AAG55167.l|AΞ005260_6 (AΞ005260) putative transcriptional regulator [Escherichia coli

0157:H7] SEQ ID n~915 pir| |C64816 hypothetical protein b0795 precursor

- Ξscherichia coli gb|AAC73882.1 | (AΞ000181)

Contig9 from putative membrane protein [Escherichia coli K12] SEQ ID n° 7357 PL-1796.1 1701512 to 753 dbj |BAA35455.I| (D90716) Hypothetical protein

1702504 f355 [Escherichia coli] dbj |BAA35461.l| (D90717) Hypothetical protein f355 [Escherichia coli] SEQ ID n~916

Contig9 from sp|P75776|YBHF_ECOLI HYPOTHETICAL ABC

SEQ ID n° 7358 PL-1797.1 1702514 to 823 TRANSPORTER ATP-BINDING PROTEIN YBHF

1704253 SEQ ID n~917

Contig9 from gb|AAG60553.l|AF250767_l (AF250767) ElsD

SΞQ ID n° 7359 PL-1798.1 1704250 to 843 [uncultured bacterium pCosFSl]

1705410 SEQ ID n~918

Sp|P75774|YBHR_ECOLI HYPOTHETICAL 41.6 KDA

Contig9 from PROTEIN IN MOAE-RHLE INTERGENIC REGION SEQ ID n° 7360 PL-1799.1 1705423 to 863 pir| |H64815 ybhR protein - Escherichia coli

1706529 gb|AAC73879.l| (AE000181) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~919

TABLEAU II

Contig9 from pir|]S44207 hypothetical protein 337 - Coxiella SEQ ID n° 7361 PL-1800.1 1706816 to 40% burnetii

1707970 SEQ ID n~922

^" Contιg9 from emb^~| CAB7124 .11 (AL138598) 2-amino-3- SEQ ID n° 7362 PL-1801.3 1708078 to 343 ketobutyrate coenzyme A ligase. [Streptomyces

1709424 coelicolor A3 (2)] #N/A

SP|P7576-8^""| BΗIΓECOLI HYPOTHETICAL 25.9 KDA

PROTEIN IN MOAE-RHLE INTERGENIC REGION

Contig9 from pir] |B64815 ybhL protein - Escherichia coli SEQ ID n° 7363 PL-1802.1 1710137 to 803 gb|AAC73873.l| (AE000181) orf, hypothetical

1710847 protein -[Escherichia coli K12] dbj | BAA35444.11

(D90716) Hypothetical protein, 23.5K

[Escherichia coli] SEQ ID n~924 sp|P30749|MOAE_ECOLI MOLYBDOPTERIN [MPT]

CONVERTING FACTOR, SUBUNIT 2 (MOLYBDENUM

COFACTOR BIOSYNTHESIS PROTEIN E) (MOLYBDOPTERIN

CONVERTING FACTOR LARGE SUBUNIT) pir| |S31883 molybdopterin biosynthesis protein Ξ chain

Contig9 from

[validated] - Ξscherichia coli SEQ ID n° 7364 PL-3936.1 1711030 to m 843 emb|CAA49865.l| (X70420) moaE [Escherichia coli]

1711482 gb|AAC73872.l| (AE000181) molybdopterin converting factor, subunit 2 [Escherichia coli K12] dbj |BAA35443.l| (D90716)

Molybdopterin-converting factor 16k chain

[Escherichia coli] SEQ ID n~3096

Contig9 from gb|AAG55155.l[AE005259_6 (AΞ005259) SEQ ID n° 7365 PL-6556.1 1711486 to m 783 molybdopterin biosynthesis [Ξscherichia coli

1711731 0157 :H7] #N/A

TABLEAU II

sp|P30747|MOAC_ECOLI MOLYBDENUM COFACTOR

BIOSYNTHESIS PROTEIN C pir||G64814 molybdenum cofactor biosynthesis protein-C—[validated] -

Escherichia coli dbj [BAA35441. l| (D90716) MoaC

Contig9 from protein. [Escherichia coli] gb |AAC73870.1 | SEQ ID n° 7366 PL-3935.1 1711728 to m 843

(AE000181) molybdopterin biosynthesis, protein C 1712207

[Ξscherichia coli K12] gb|AAG55154.l|AE005259_5 (AE005259) molybdopterin biosynthesis, protein C

[Escherichia coli 0157-.H7] SΞQ ID n~3095

ContigS from gb|AAG55152.l|AΞ005259_3 (AE005259) SEQ ID n° 7367 PL-1803.1 1712247 to 793 molybdopterin biosynthesis, protein A

1713230 [Escherichia coli 0157:H7] SΞQ ID n~925 Contig9 from SEQ ID n° 7368 PL-6554.1 1713246 to No Hits found

1713353 #N/A sp|P75767|YBHK_ΞCOLI HYPOTHETICAL 32.8 KDA

PROTEIN IN UVRB-MOAA INTERGENIC REGION

Contig9 from pir| |D64814 ybhK protein - Escherichia coli SEQ ID n° 7369 PL-1804.1 1713639 to 333 gb| AAC73867.l| (AE000180) putative structural

1714547 protein [Escherichia coli K12] dbj |BAA35438.1 |

(D90716) Hypothetical protein l [Escherichia coli] SEQ ID n~926 ref |NP_073225.1 | ransposase of IS630 [Salmonella enterica serovar Choleraesuis] dbj |BAA01531.1 [

Contig9 from

(D10689) M5 protein [Salmonella choleraesuis] SEQ ID n° 7370 PL-1805.1 1715372 to m 723 dbj |BAB20556.l| (AB040415) ransposase of IS630

1716385

[Salmonella enterica serovar

Choleraesuis] SEQ ID n~927 pir| |H83457 hypothetical protein PA1508

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 7371 PL-6552.1 1716806 to 443 (Strain PAOl) gb |AAG04897.1 |AE004579_9

1717078 (AE004579) hypothetical protein [Pseudomonas aeruginosa] #N/A

TABLEAU II

pir[|E83542 hypothetical protein PA0821

Contigs from [imported] - Pseudomonas aeruginosa SEQ ID n° 7372 PL-1806.1 1717082 to 303 (strain PAOl) gb|AAG04210.1 |AE004517_5

1718227 (AE004517) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~928 pir| |E83542 hypothetical protein PA0821

Contig9 from [imported] Pseudomonas aeruginosa SEQ ID n° 7373 PL-1807.1 1718265 to m 273 (strain PAOl) gb | AAG04210.1 | E004517_5

1719410 (AEO04517) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~929

Contig9 from

SEQ ID n° 7374 PL-1808.1 1719425 to m No Hits found

1720630 SEQ ID n~930

Contig9 from gb]AAG54536.l|AE005199_6 (AE005199) Z0267 gène

SEQ ID n° 7375 PL-1309.1 1720786 to m 413 product [Escherichia coli 0157:H7]

1722900 SEQ ID n~931 sp|P07025|UVRB_ECOLI EXCINUCLEASE ABC SUBUNIT B pir] |BVECUB excinuclease ABC chain B - Ξscherichia coli emb |CAA27357. l| (X03722) uvrB

Contig9 from gène product (AA l - 673) [Ξscherichia coli] SEQ ID n° 7376 PL-1811.1 1723550 to m 903 gb|AAC73866.l| (AΞ000180) DNA repair; excision

1725559 nuclease subunit B [Escherichia coli

K12] gb|AAG55150.l|AE005259_l (AΞ005259) DNA repair; excision nuclease subunit B [Escherichia coli 0157 :H7] SEQ ID n~933

Contig9 from SEQ ID n° 7377 PL-1812.1 1727233 to No Hits found

1727847 SEQ ID n~934 pir| |A72517 hypothetical protein APE2110 -

Contig9 from

Aeropyrum pernix (strain Kl) dbj | BAA81121.1 | SEQ ID n° 7378 PL-1813.1 1727848 to 393

(AP000063) 247aa long hypothetical protein

1728741

[Aeropyrum pernix] SEQ ID n~935

TABLEAU II

sp|P13000 |BIOD_ΞCOLI DETHIOBIOTIN SYNTHETASE

(DETHIOBIOTIN SYNTHASE) (DTB SYNTHETASE)

Contig9 from

(DTBS) pir| | SYECDB_dethiobiotin synthase (EC SEQ ID n° 7379 PL-1814.1 -1-729058 -to— m 763

6.3.3.3) - Ξscherichia coli gb|AAC73865.1 |

1729738

(AΞ000180) dethiobiotin synthetase [Ξscherichia coli K12] SEQ ID n~936

ContigS from sp | P365711 BIOC sËRMA BIOTIN SYNTHESIS PROTEIN

SEQ ID n° 7380 PL- 1815.1 1729731 to m 69% BIOC dbj |BAA04287.l| (D17468) the product of

1730498 bioC [Serratia marcescens] SEQ ID n~937

Contig9 from gb|AAG50556.l|AF250768_l (AF250768) KAPA-

SEQ ID n° 7381 PL-1816.1 T730482 to m 793 synthetase [uncultured bacterium pCosFSl]

1731633 SΞQ ID n~938

Contig9 from sp|P36569(BIOB_SERMA BIOTIN SYNTHASΞ (BIOTIN

SEQ ID n° 7382 PL- 1817.1 1731633 to m 893 SYNTHETASE) dbj |BAA04285.1 | (D17468) biotin

1732670 synthetase [Serratia marcescens] SEQ ID n~939

Contig9 from gb|AAF04396.l|AF191556_4 (AF191556) BioA

SEQ ID n° 7383 PL-1818.1 1732765 to 863 [Xenorhabdus nematophilus]

1734036 SEQ ID n~940

Contig9 from

SEQ ID n° 7384 PL-1819.1 1734248 to m No Hits found

1734913 SΞQ ID n~941

ContigS from

SΞQ ID n° 7385 PL-6542.1 1735015 to No Hits found

Contig9 from

SEQ ID n° 7386 PL-6541.1

Contig9 from gb|AAF04393.l|AF191556_l (AF191556) YbhE

SEQ ID n° 7387 PL-1821.1 1736133 to 673 [Xenorhabdus nematophilus]

1737119 SEQ ID n~943

TABLEAU II

sp|P21829|YBHA_ECOLI HYPOTHETICAL 30.2 KDA

PROTEIN IN MODC-BIOA INTERGENIC REGION pir| |F64812 ybhA protein - Escherichia coli

(strain K-12) gb| AAB60177.1 | (U27192) unknown

Contigδ from

[Escherichia coli] gb | AAC73853.1 | (AE000179)

SEQ ID n° 7388 PL-1822.1 1737265 to 72% putative phosphatase [Escherichia coli K12]

1738083 dbj |BAA35430.l| (D90715) Hypothetical 30 ^".2 kd protein in mode 3 'région.

[Escherichia coli] prf | | 2204295E mode gène

[Escherichia coli] SEQ ID n~944 pir| |BVECHD molybdenum transportr protein mode -

Escherichia coli gb] AAB60173.l] (U27192) ModC

[Ξscherichia coli] dbj |BAA35429.l| (D90715)

Contig9 from

Molybdenum transport ATP-binding protein ModC. SΞQ ID n° 7389 PL-1823.1 1738160 to m 773

[Escherichia coli] gb ( AAC73852.1 | (AE000179)

1739224

ATP-binding component of molybdate transport

[Ξscherichia coli K12] prf | | 22042S5D modC gène

[Ξscherichia coli] SEQ ID n~945 sp|P09834|MODB_ECOLI MOLYBDENUM TRANSPORT SYSTEM

PERMEASE PROTEIN MODB gb | AAB00836.1 | (L34009) hydrophobic membrane-bound protein [Escherichia

Contig9 from coli] gb|AAB60l72.l| (U27192) ModB [Escherichia SEQ ID n° 7390 PL-1824.1 1739218 to m 85% coli] gb|AAB06894.l| (U07867) part of a

1739916 molybdenum periplasmic binding protein dépendent transport system [Ξscherichia coli] prf | |2204295C modB gène [Escherichia coli] SEQ ID n~946

Contig9 from gb|AAG55092.l]AE005254_4 (AE005254) molybdate-

SEQ ID n° 7391 PL-1825.1 1740053 to 723 binding periplasmic protein; permease

1740823 [Escherichia coli 0157 :H7] SEQ ID n~947

Contig9 from dbj |BAA35426.l| (D90715) ORF_ID :O180#2

SΞQ ID n° 7392 PL-6540.1 1741197 to m 533 [Escherichia coli]

1741331 #N/A

Contig9 from pdb|lB9N]A Chain A, Regulator From Escherichia

SΞQ ID n° 7393 PL-1826.1 1741514 to 723 Coli pdb]lB9N|B Chain B, Regulator From

1742305 Escherichia Coli SEQ ID n~948

TABLEAU II

Conti 9 from gb|AAG55089.l|AΞ005254_l (AΞ005254) ATP-binding SEQ ID n° 7394 PL-1827.1 1742482 to 80% component of molybdate transport system

1743957 [Escherichia coli 0157.-H7] SEQ ID n~949 pir||H83004 hypothetical protein PA5132

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 7395 PL-1828.2 1744362 to 653 (Strain PAOl) g j AAG08517.l| AE004926_7

1745189 (AE0^~0Tf92 ) hypothetical protein [Pseudomonas aeruginosa] #N/A sp|P31217[PMGl_EC0LI PHOSPHOGLYCERATE MUTASE 1

(PHOSPHOGLYCEROMUTASE 1) (PGAM 1) (BPG-DΞPENDΞNT PGAM 1) pir] |C64811 phosphoglycerate mutase (ΞC 5.4.2.1) 1 -

Escherichia coli gb j AC7384 . l] (AE000178)

Contig9 from phosphoglyceromutase 1 [Escherichia coli K12] SEQ ID n° 7396 PL- 1829.1 1745349 to 903 dbj |BAA35417.l[ (D90714) Phosphoglycerate mutase

1746101

1 (EC 5.4.2.1) (phosphoglyceromutase l) (pgam l) (bpg-dependent pgam l) .

[Escherichia coli] gb|AAG5508 .1 |AE005253_6

(AE005253) phosphoglyceromutase 1 [Escherichia coli 0157.-H7] SEQ ID n~951

TABLEAU II

sp|P00886|AROG_ECOLI PHOSPHO-2-DΞHYDRO-3-

DEOXYHΞPTONATΞ ALDOLASE, PHΞ-SENSITIVΞ

(PHOSPHO-2-KETO-3-DΞOXYHΞPTONATΞ ALDOLASE) (DAHP

SYNTHETASE) (S-DEOXY-D-ARÂBINÔ^HΞPTULOSONATE 7-

PHOSPHATE SYNTHASE) pir| |ADΞCHF 2- dehydro-3-deoxyphosphoheptonate aldolase (EC

4.1.2.15) Phe-sehsitive) -

Escherichia coli pdb|lGGl|A Chain A, Crystal

Structure Analysis Of Dahp Synthase In Complex

With Mn2+ And 2-Phosphoglycolate pdb|lGGl|B

Contig9 from

Chain B, Crystal^" Structure Analysis Of Dahp SEQ ID n° 7397 PL-1830.1 1746198 to m 90%

Synthase In Complex With Mn2+ And 2-

1747250

Phosphoglycolate pdb|lGGl|c Chain C, Crystal

Structure Analysis Of Dahp Synthase In Complex

With Mn2+ And 2-Phosphoglycolate pdb|lGGl|D

Chain D, Crystal Structure Analysis Of Dahp

Synthase In Complex With Mn2+ And 2-

Phosphoglycolate pdb|lQR7]D Chain D, Crystal

Structure Of Phenylalanine-Regulated 3-Deoxy-D-

Arabino-Heptulosonate-7-Phosphate Synthase From

Ξscherichia Coli Complexed With Pb2+ And Pep pdb|lQR7|A Chain A, Crystal Structure Of SEQ ID n~953

Contig9 from gb|AAG55080.l|AΞ005253_2 (AE005253) required for SEQ ID n° 7398 PL-1831.1 1747642 to m 79° NMN transport [Escherichia coli 0157 :H7]

1748367 SEQ ID n~954 sp|P11458|NADA__EC0LI QUINOLINATE SYNTHETASE A pir | | SYECQA quinolinate synthetase nadA

[validated] - Escherichia coli dbj |BAA35409.1 |

Contig9 from

(D90713) Quinolmate synthetase A. [Escherichia SEQ ID n° 7399 PL-1832.1 1748544 to m 82% coli] dbη |BAA35412.l| (D90714) Quinolinate

1749584 synthetase A. [Escherichia coli] gb|AAC73837. l|

(AE000177) quinolinate synthetase, A protein

[Escherichia coli K12] SEQ ID n~955

Contig9 from emb|CAB88835.l| (AL353832) putative ABC- SEQ ID n° 7400 PL-1833.1 1750598 to p 43% transport protein, ATP-binding component.

1751362 [Streptomyces coelicolor A3 (2) ] SEQ ID n~956

TABLEAU II

pir| |H71196 hypothetical protein PH1846 -

Contig9 from Pyrococcus horikoshii db |BAA30967.l|

SEQ ID n° 7401 PL-3932.2 1751669 to 383 AP000007) 273aa long hypothetical protein __

1752229

[Pyrococcus horikoshii] #N/A pir| |H75377 conserved hypothetical protein -

Contig9 from

Deinococcus radiodurans (strain RI)

SEQ ID ne^. -74-0-2—PL- 1834.2 1752468 to 32% gb|AAFlιl45.ι|AΞθ020θ2_3 (AE002002) conserved

1752992 hypothetical protein [Deinococcus radiodurans] #N/A

Contig9 from pir|]si8687 Sc/SvN protein - Escherichia coli

SEQ ID n° 7403 PL-1835.1 1753150 to m 323 plasmid p!5B emb| CAA44050.l| (X62121) DNA

1753968 inversion product [Escherichia coli] SEQ ID n~958

Contig9 from pir||S!8690 Sc/SvQ protein - Escherichia coli

SEQ ID n° 7404 PL-1836.1 1754385 to m 32% plasmid pl5B emb|CAA44053.l| (X62121) DNA

1755299 inversion product [Escherichia coli] SEQ ID n~959

Contig9 from

SEQ ID n° 7405 PL-6538.1 1755705 to m No Hits found

1756088 #N/A

Contig9 from

SEQ ID n" 7406 PL-6537.1 1756085 to m No Hits found

1756441 #N/A

ContigS from pir| |S18690 Sc/SvQ protein - Escherichia coli

SEQ ID n° 7407 PL-1837.1 1756851 to m 31% plasmid pl5B emb|CAA44053. l| (X62121) DNA

1757753 inversion product [Escherichia coli] SEQ ID n~960

Contig9 from

SEQ ID n° 7408 PL-6536.1 1758000 to m No Hits found

1758146 #N/A pir| |S25259 streptomycin résistance protein

Contig9 from Bacteroides sp. transposon Tn4551

SEQ ID n° 7409 PL-1838.2 1758557 to P 493 gb|AAA27459.l| (M72415) streptomycin

1759408 adenyltransferase [Transposon Tn4551] #N/A

Contig9 from

SEQ ID n° 7410 PL-6535.1 1759488 to No Hits found

1759646 #N/A

TABLEAU II

sp|P45955|YBGF_ECOLI HYPOTHETICAL 28.2 KDA

PROTΞIN IN PAL-LYST INTΞRGENIC REGION

PRECURSOR pir| |j_64810 ybgF protein precursor -

Contig9—rom

Escherichia coli gb] AAC73836.1 | (AΞ000177) orf, SΞQ ID n° 7411 PL-1839.2 1761092 to m 803 hypothetical protein [Escherichia coli K12]

1761868 dbj |BAA35408.l| (DS0713) Hypothetical 28.2 kd protein in pal-ïysT intergenic région. [Escherichia coli] #N/A sp | PO 7176 | PAL_ECOLI PEPTIDOGLYCAN-ASSOCIATED

LIPOPROTEIN PRECURSOR pir| | LPΞCPG peptidoglycan associated Tipoprotein precursor - Escherichia coli emb|CAA46673.l| (X65796) peptidoglycan- associated lipoprotein [Ξscherichia coli] emb|CAA28771.l[ (X05123) precursor polypeptide

Contig9 from (AA-21 to -1) [Escherichia coli] SEQ ID n° 7412 PL-3931.2 1761878 to m 81% db |BAA35407.l| (D90713) Peptidoglycan-

1762378 associated lipoprotein precursor. [Escherichia coli] gb | AAC73835.1 | (AE000177) peptidoglycan-associated lipoprotein

[Escherichia coli K12] gb[AAG55077.l[AE005252_13 (AΞ005252) peptidoglycan-associated lipoprotein

[Escherichia coli 0157 :H7] #N/A pdb|lC5K|A Chain A, The Structure Of Tolb, An

Contig9 from Ξssential Component Of The Tol-

SEQ ID n° 7413 PL-1840.1 1762421 to m 863 Dependent Translocation System And Its

1763713 Interactions With The Translocation

Domain Of Colicin Ξ9 SEQ ID n~964

Contig9 from gb|AAG55075.l|AE005252_ll (AE005252) membrane

SEQ ID n° 7414 PL-1842.1 1763927 to m 713 spanning protein, required for outer membrane

1764997 integrity [Escherichia coli 0157 :H7] SEQ ID n~966

TABLEAU II

sp | PO5829 | TOLRJ3COLI TOLR PROTEIN pir | | BVΞCTR tolR protein - Escherichia coli gb|AAA83921.1 |

(M16489) ORF 3; putative [Escherichia coli] dbj [BAA35404.1| (D90713) TolR protein

[Escherichia coli] gb|AAC73832.l| (AE000177)

Contig9 from putative inner membrane protein, involved in the

-SEQ-ID_n° 7415 PL-6533.1 1765043 to m 82-%- tonB-independent uptake of group A colicins

1765468

[Escherichia coli K12] gb|AAG55074.l|AE005252_10 (AE005252) putative inner membrane protein, involved in the tonB-independent uptake^" ôTT^~gfoup A colicins

[Escherichia coli 0157 :H7] #N/A sp|P05828 |TOLQ_ECOLI TOLQ PROTEIN pir||BVECTQ biopolymer transport protein tolQ - Ξscherichia coli gb|AAA83919.l| (M16489) ORF 2; putative

[Escherichia coli] dbj |BAA35403.1 | (D90713)

TolQ protein. [Escherichia .coli] gb|AAC73831. l|

Contig9 from (AEO00177) inner membrane protein, membrane-

SEQ ID n° 7416 PL-1843.1 1765483 to 90% spanning, maintains integrity of cell

1766178 envelope,- tolérance to group A colicins [Escherichia coli K12] gb|AAG55073.l|AE005252_9 (AE005252) inner membrane protein, membrane-spanning, maintains integrity of cell envelope; tolérance to group A colicins [Escherichia coli 0157 :H7] SEQ ID n~967 sp|P08999 |YBGC_ECOLI 15.6 KDA PROTEIN IN CYDB-

TOLQ INTERGENIC REGION pir | [WMEC15 ybgC protein

- Escherichia coli gb|AAA83918.1 | (M16489) ORF

1; putative [Escherichia coli] gb| AAC73830.1 |

Contig9 from

(AEO00177) orf, hypothetical protein SEQ ID n° 7417 PL-3930.1 1766175 to m 663

[Escherichia coli K12] dbj |BAA35402.l| (D90713)

1766579

15.5k protein (tolAB operon 5' région) .

[Ξscherichia coli] gb] AAG55072.l| AE005252_8

(AE005252) orf, hypothetical protein

[Escherichia coli 0157 :H7] SEQ ID n~3093

TABLEAU II

sp|P11027|CYDB_ECOLI CYTOCHROME D UBIQUINOL

OXIDASE SUBUNIT II (CYTOCHROME BD-I OXIDASE

SUBUNIT II) pir| |B28940 cytochrome d ubiquinol oxidase (EC 1.10.3.-) chain II - Escherichia coli gb|AAA18805. l| (J03939) cytochrome oxidase d subunit II [Escherichia coli] dbj |BAA35400.1 |

-Contig9 from

(D90713) Cytochrome d ubiquinol oxidase subunit

SEQ ID n° 7418 PL-1844.1 1767125 to 833

II (EC 1.10.3.-). [Escherichia coli]

1768264 gb|AAC73828.l] (AE000176) cytochrome d terminal oxidase polypeptide subunit II [Escherichia coli K12] gb| AAG55070.l| AE005252_

(AE005252) cytochrome d terminal oxidase polypeptide subunit II [Escherichia coli 0157 :H7] SEQ ID n~968

Contig9 from gb|AAA18804.l| (J03939) cytochrome oxidase d SEQ ID n° 7419 PL-1845.1 1768279 to 913 subunit I [Escherichia coli]

1769847 SEQ ID n~969 Contig9 from SEQ ID n° 7420 PL-6530.1 1771168 to m No Hits found

1771311 #N/A Contig9 from SEQ ID n° 7421 PL-6529.1 1771827 to m No Hits found

1772201 #N/A pir] |A83124 hypothetical protein PA4182

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 7422 PL-1846.1 1772222 to 463 (strain PAOl) gb|AAG07569.1 |AΞ004834_9

1772860 (AEO04834) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~970

Contig9 from SEQ ID n° 7423 PL-3928.1 1772871 to m No Hits found

1773335 SEQ ID n~3090 sp | Q9ZHE5 | HIS8_BUCAP HISTIDINOL-PHOSPHATE

Contig9 from AMINOTRANSFERASE (IMIDAZOLE ACETOL-PHOS HATE SEQ ID n° 7424 PL-1847.1 1773349 to 403 TRANSAMINASE) gb |AAC97356.1 | (AF067228)

1774455 histidinolphosphate aminotransferase [Buchnera aphidicola] SEQ ID n~971

TABLEAU II

pir| |H72265 hypothetical protein TM1336 -

Contig9 from

Thermotoga maritima (strain MSB8) SEQ ID n° 7425 PL- 1848.1 1774497 to m 38% gb|AAD36408.l|AE001788_3_ AΞ001788) permease,

177568-7— putative [Thermotoga maritima] SΞQ ID n~972

Contig9 from emb|CAB677l8.l| (AJ271405) putative carbamoyi- SEQ ID n° 7426 PL-1849.1 1775745 to m 19% phosphate-synthetase [Streptomyces

1778051 ⁼ rochei] SEQ ID n~973 Contig9 from emb|CAB92560.l| (AL356812) putative carboxylase. SEQ ID n° 7427 PL-1850.1 1778207 to m 26% [Streptomyces coelicolor A3 (2)]

1779460 SEQ ID n~975 Contig9^~ from gb|AAK02181.l| (AE006045) unknown [Pasteurella SEQ ID n° 7428 PL-1851.1 1779500 to m 36% multocida]

1780249 SΞQ ID n~976 sp | O67733 | ILVE_AQUAE PROBABLE BRANCHED-CHAIN

AMINO ACID AMINOTRANSFERASE (BCAT) pir| |C70463

Contig9 from branched-chain amino acid aminotransferase - SEQ ID n° 7429 PL-1852.1 1780282 to m 61%

Aquifex aeolicus gb|AAC07697. l| (AE000762)

1781055 branched-chain amino acid aminotransferase

[Aquifex aeolicus] SΞQ ID n~977

Contig9 from dbj |BAA82878.l| (AB024335) 3- (3- SEQ ID n° 7430 PL-1853.1 1781226 to m 36% hydroxyphenyl)propionate hydroxylase [Comamonas

1782848 testosteroni] SΞQ ID n~978 Contig9 from SEQ ID n° 7431 PL-1854.1 1782858 to m No Hits found

1784144 SEQ ID n~979

Sp|P42253|YCBU_BACSU HYPOTHΞTICAL 40.8 KD

PROTEIN IN PCP-LMRB INTERGENIC REGION

ContigS from PRECURSOR (ORF21) pir| |Ξ69754 nifS protein SEQ ID n° 7432 PL-1855.1 1784193 to m 46% homolog ycbU - Bacillus subtilis

1785335 dbj |BAA22227.l| (AB000617) YcbU [Bacillus subtilis] emb]CAB12060.1] (Z99105) similar to

NifS protein homolog [Bacillus subtilis] SEQ ID n~980 pir| |T36536 probable oxidoreductase -

Contig9 from

Streptomyces coelicolor emb|CAB42033.l| SEQ ID n° 7433 PL-1856.1 1785341 to m 423

(AL049754) putative oxidoreductase [Streptomyces

1786042 coelicolor A3 (2) ] SEQ ID n~981

TABLEAU II

Sp|P07459|SUCD_ECOLI SUCCINYL-COA SYNTHETASE ALPHA CHAIN (SCS-ALPHA) pi | | ΞYECΞA succinate-- CoA ligase (ADP-forming) (EC 6.2.1.5) alpha_ chain - Escherichia coli gb|AAA23900.l| (J01619) succinyl-CoA synthetase alpha-subunit [Escherichia coli]

Contig9 from dbj |BAA35395.l] (D90711) Succinate-CoA ligase

SEQ ID n° 7434 PL-1857.1 1786786 to 91%

(ADP-forming) (EC 6.2.1.5) alpha

1787661 chain. [Escherichia coli] gb|AAC73823.1 |

(AE000176) succinyl-CoA synthetase, alpha subunit [Escherichia coli K12] gb|AAG55053.l|AE005251_2 (AE005251) Succinyl-CoA synthetase, alpha subunit [Escherichia coli

0157 :H7] SΞQ ID n~982

TABLEAU II

sp|P07460|SUCC_ECOLI SUCCINYL-COA SYNTHΞTASE

BETA CHAIN (SCS-BETA) pir| | SYECSB succinate--

CoA ligase (ADP-forming) (EC 6.2.1.5) beta chain

Escherichia coli pdb|lSCU|B Chain

B, Succinyl-Coa Synthetase (Succinate-Coa

Ligase) (Adp-Forming) (E.C.6.2.1.5) pdb|lSCtf|Ξ Chain^" Ë, Succinyl-Coa Synthetase

(Succinate-Coa Ligase) (Adp-Forming)

(F. C.6.2.1.5) pdb|2SCU|B chain B, A Detailed

Description Of The Structure Of Succinyl-Coa

Contig9 from Synthetase^{^} From Escherichia Coli pdb|2SCU|E SΞQ ID n° 7435 PL-1858.1 1787664 to m 923 Chain E, A Detailed Description Of The Structure

1788830 Of Succinyl-Coa Synthetase From

Escherichia Coli gb| AAA23899.l| (J01619) succinyl-CoA synthetase beta-subunit

[Escherichia coli] dbj |BAA35394.l| (D90711)

Succinate-CoA ligase (ADP-forming) (EC 6.2.1.5) beta chain. [Escherichia coli] gb|AAC73822.l| (AE000176) succinyl-CoA synthetase, beta subunit [Escherichia coli

K12] gb|AAG55052.l|AΞ005251_l (AE005251) succinyl-CoA synthetase, beta subunit

[Escherichia coli 0157 :H7] SΞQ ID n~983

TABLEAU II

sp | 07016 | OD02_ECOLI DIHYDROLIPOAMIDΞ

SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE

DEHYDROGENASΞ COMPLEX (E2) pir | |XUECSD dihydrolipoamide S-succinyltransferase (EC

2.3.1.61) [validated] - Escherichia coli emb|CAA25284.l| (X00664) E20 component

[Escherichia coli] gb| AA238987l| (J01619) dihydrolipoamide succinyltransferase

[Escherichia coli] dbj |BAA35393.l| (D90711)

Contig9 from

Dihydrolipoamide succinyltransferase component

SEQ ID n° 7436 PL-1860.1 1788997 to m 873

(E2) of 2 -oxoglutarate dehydrogenase 1790217 complex (EC 2.3.1.61). [Escherichia coli] gb|AAC7382l.l| (AE000175) 2-oxoglutarate dehydrogenase

(dihydrolipoyltranssuccinase E2 component)

[Escherichia coli K12] gb|AAG55051.l|AE005250_10 (AE005250) 2- oxoglutarate dehydrogenase

(dihydrolipoyltranssuccinase E2 component)

[Escherichia coli 0157 :H7] SEQ ID n~985 s | PO7015 | 0D01_EC0LI 2 -OXOGLUTARATE

DEHYDROGENASE El COMPONENT (ALPHA-KΞTOGLUTARATΞ

DEHYDROGENASE) pir| | DEECOG oxoglutarate dehydrogenase (lipoamide) (EC 1.2.4.2) -

Contig9 from

Escherichia coli dbj |BAA35392.1 |

SEQ ID n° 7437 PL-1861.1 1790232 to m 903

(D90711) Oxoglutarate dehydrogenase (lipoamide)

1793039

(EC 1.2.4.2) [Escherichia coli] gb|AAC73820.l| (AE000175) 2 -oxoglutarate dehydrogenase (decarboxylase component)

[Ξscherichia coli K12] SEQ ID n~986

Contig9 from gb|AAG55048.l|AE005250_7 (AE005250) succinate SEQ ID n° 7438 PL-1862.1 1793306 to m 953 dehydrogenase, iron sulfur protein

1794022 [Escherichia coli 0157 :H7] SEQ ID n~987

TABLBAU II

sp|P10444|DHSA_ECOLI SUCCINATE DEHYDROGENASΞ FLAVOPROTEIN SUBUNIT pir] |DEECSF succinate dehydrogenase (ΞC 1.3.99.1) flavoprotein -

Contig9 from Ξscherichia coli dbj |BAA35390.1 | SEQ ID n° 7439 PL-1863.1 17S4059 to m 963 (D90711) Succinate dehydrogenase (EC 1.3.99.1)

1795825 flavoprotein [Escherichia coli] gb|AAC73817.l] (AE000175) succinate dehydrogenase, flavoprotein subunit

[Ξscherichia coli K12] SEQ ID n~988 sp|P10445|DHSD_ΞCOLI SUCCINATΞ DEHYDROGENASE

^{^}HYDROPHOBIC MEMBRANE ANCHOR PROTEIN pir| | DÉËCS2 succinate dehydrogenase (ΞC 1.3.99.1) 13K protein - Escherichia coli emb|CAA25486.l| (X00980) succinate dehydrogenase

Contig9 from hydrophobic subunit (sdhD) (aa 1-114) SEQ ID n° 7440 PL-6520.1 1795826 to m 753 [Escherichia coli] gb|AAA23894.l| (J01619)

1796173 succinate dehydrogenase [Escherichia coli] dbj |BAA35389.l| (D90711) Succinate dehydrogenase

(ΞC 1.3.99.1) 13k hydrophobic protein [Escherichia coli] gb ] AAC73816.1 |

(AE000175) succinate dehydrogenase, hydrophobic subunit [Ξscherichia coli K12] #N/A

TABLEAU II

sp|P10446|DHSC_ECOLI SUCCINATE DEHYDROGENASE

CYTOCHROME B-556 SUBUNIT pir| |DΞECS4 succinate dehydrogenase (EC 1.3.99.1) cytochrome b556 -

Escherichia coli emb | CAA25485.1 |

(X00980) succinate dehydrogenase (sdhc) hydrophobic subunit (aa 1-1 8)

[Escherichia coli] gb| AAA23893.1 | (J01619)

Contig9 from succinate dehydrogenase [Escherichia coli]

SEQ ID n° 7441 PL-6519.1 1796167 to 643 gb|AAA246l6.l| (M28989) succinate dehydrogenase

1796499 [Escherichia coli] dbj |BAA35388. l| (D90711)

Succinate dehydrogenase cytochrome b-556 subunit. [Escherichia coli] gb|AAC738l5.l| (AE000175) succinate dehydrogenase, cytochrome b556 [Escherichia coli K12] gb|AAG55045.l|AΞ005250_4 (AΞ005250) succinate dehydrogenase, cytochrome b556

[Ξscherichia coli 0157 :H7] #N/A

ContigS from

SEQ ID n° 7442 PL-6518.1 1796436 to No Hits found

1796612 #N/A pir| |YKEC citrate (si) -synthase (ΞC 4.1.3.7) -

Contig9 from Ξscherichia coli dbj |BAA35387.l| (D90711)

SEQ ID n° 7443 PL-1864.1 1797426 to 863 Citrate synthase (ΞC 4.1.3.7). [Escherichia

1798709 coli] gb|AAC738i4.ι| (AE000175) citrate synthase [Ξscherichia coli K12] SEQ ID n~989 sp|P75743|YBGI_EC0LI HYPOTHETICAL 26.9 KDA

PROTEIN IN PHRB-NEI INTERGΞNIC RΞGION pir] |E64806 ybgl protein - Escherichia coli

Contig9 from gb|AAC73804.l| (AE000174) orf, hypothetical

SEQ ID n° 7444 PL-1865.1 1799062 to m 753 protein [Escherichia coli K12] dbj |BAA35374.l |

1799805 (D90710) Hypothetical protein HI0105

[Escherichia coli] gb]AAG55033.1 |AE005249_4

(AΞ005249) orf, hypothetical protein

[Escherichia coli 0157 :H7] SΞQ ID n~990

TABLEAU II

sp | P28913 | YBFA_FCOLI HYPOTHETICAL 8.3 KDA

PROTEIN IN KDPA-RHΞC INTERGENIC REGION

PRECURSOR pir| |B64805 ybfA protein__^__

Escherichia coli gb| AAC63071.l| (L02373)

ContigS from unknown [Escherichia coli] gb | AAC73793.1 |

SEQ ID n° 7445 PL-6517.1 1799872 to 52% (AE000173) orf, hypothetical protein

1800081 [Escherichia coli K12] dbj |BAA35358.l| (D90709)

Hypothetical 8.3 kd protein in rhsC 5 ' région precursor. [Ξscherichia coli] gb|AAG55020.l|AΞ005248_l (AE005248) orf, hypothetical protein [Escherichia coli 0157 :H7] #N/A

ContigS from

SEQ ID n° 7446 PL-3926.1 1800600 to No Hits found

1800980 SEQ ID n~3089

Contig9 from dbj |BAB06239.l| (AP001515) transposase related

SEQ ID n° 7447 PL- 1856.1 1801073 to 213 protein (20) [Bacillus halodurans]

1802134 SEQ ID n~991 sp | 03959 | TKA_ECOLI POTASSIUM-TRANSPORTING

ATPASE A CHAIN (POTASSIUM-TRANSLOCATING

ATPASE A CHAIN) (ATP PHOSPHOHYDROLASE

[POTASSIUM-TRANSPORTING] A CHAIN) (POTASSIUM

BINDING AND TRANSLOCATING SUBUNIT A) pir] |PWECAK H+/K+-exchanging ATPase (EC

3.6.1.36) chain A [validated] -

Contig9 from

Escherichia coli gb|AAB96335.l| (K02670) kdpA

SEQ ID n° 7448 PL-1867.1 1802635 to 82%

[Escherichia coli] dbj |BAA35356.1 | (D90709)

1804341

Potassium-transporting ATPase (EC 3.6.1.36), a chain (ATP phosphohydrolase

(potassium-transporting) , A chain) .

[Escherichia coli] gb | AAC73792.l| (AE000173)

ATPase of high-affinity potassium transport system, A chain [Escherichia coli

K12] SEQ ID n~992

ContigS from SΞQ ID n° 7449 PL-1869.1 1804362 to 863 gb|AAB96336.l| (K02670) kdpB [Escherichia coli]

1806428 SEQ ID n~993

TABLΞAU II

Contig9 from gb|AAG55017.l|AΞ005247_8 (AΞ005247) high- SEQ ID n° 7450 PL-3925.1 1806440 to 623 affinity potassium transport system [Escherichia

1807021 coli 0157.-H7] SEQ ID n~3088 sp|P21865]KDPD_ECOLI SENSOR PROTEIN KDPD pir||B42372 histidine kinase kdpD (EC 2.7.3.-) [validated] - Escherichia coli gb|AAA24041.l |

Contig9 from (M36066) transmembrane protein (kdpD) SΞQ ID n° 7451 PL-1870.1 1807030 to 773 [Escherichia coli] dbj |BAA35352 ,l| (D90708)

1809723 Regulatory protein KdpD. [Escherichia coli] gb|AAC73789.l| (AE000173) sensor for high-affinity potassium transport System [Ξscherichia coli K12] SEQ ID n~S95 sp|P21866|KDPΞ_ΞCOLI KDP OPΞRON TRANSCRIPTIONAL RΞGULATORY PROTEIN KDPE pir| |E64804

Contιg9 from transcription regulator kdpΞ [validated] - SΞQ ID n° 7452 PL-1871.1 1809720 to 81% Ξscherichia coli gb|AAC73788.1 | (AE000173)

1810412 regulator of kdp operon (transcriptional effector) [Escherichia coli K12] SEQ ID n~996

Contig9 from SEQ ID n° 7453 PL-1872.1 1810678 to No Hits found

1812210 SEQ ID n~997 pir] |E82358 conserved hypothetical protein

Contιg9 from VC0134 [imported] - Vibrio cholerae SEQ ID n° 7454 PL-1873.1 1812643 to m 593 (group Ol strain N16961) gb|AAF933ll.l |

1813470 (AE004104) conserved hypothetical protem [Vibrio cholerae] SEQ ID n~998 pir| |A75275 methionyl-tRNA formyltransferase -

Contig9 from Deinococcus radiodurans (strain RI) SEQ ID n° 7455 PL-1874.1 1813478 to 27% gb|AAF11976.l|AΞ002073_6 (AΞ002073) methionyl-

1814158 tRNA formyltransferase [Deinococcus radiodurans] SEQ ID n~999

Contig9 from gb|AAC05838.l| (AF052516) hemolysin erythrocyte SΞQ ID n° 7456 PL-1875.1 1814149 to 55% lysis protein 2 [Prevotella

1816005 intermedia] SEQ ID n-ÎOOO

TABLΞAU II

pir| |E71622 probable membrane associated protein

Contig9 from PFB0125C - malaria parasite

SEQ ID n° 7457 PL-1876.1 1816242 to m 183 (Plasmodium falciparum) gb|AAC71815.1 (

1817444 ^~ (AEO01374) predicted membrane associated protein

[Plasmodium falciparum] SEQ ID n~ï001

Contig9 from gb|AAG45728.l|AF22944O--l—(AF229440) y4yB ^~SEQ ID n° 7458 PL-6513.1 1817431 to m 453 [Sinorhizobium fredii]

1817688 #N/A pir[ |C82395 conserved hypothetical protein

Contig9 from VCA0972 [imported] - ibrio cholerae SEQ ID n° 7459 PL-1877.1 1817792 to^" 553 (group 01 strain^~N16961) gb|AAF96868.1 |

1819024 (AEO04423) conserved hypothetical protein

[Vibrio cholerae] SEQ ID n~ï002 pir| |B75075 hypothetical protein PAB0665 -

Contig9 from

Pyrococcus abyssi (strain Orsay) SEQ ID n° 7460 PL-6512.1 1819784 to p 653 emb|CAB49903.l| (AJ248286) hypothetical protein

1820212

[Pyrococcus abyssi] #N/A sp | P36938 | PGMU_EC0LI PHOSPHOGLUCOMUTASE (GLUCOSΞ

PHOSPHOMUTASE) (PGM) pir| |G64803 phosphoglucomutase (ΞC 5.4.2.2) - Escherichia coli gb|AAA57067.1 | (U08369) phosphoglucomutase

[Ξscherichia coli] dbj (BAA35337.l| (D90707)

Contig9 from

Phosphoglucomutase (EC 5.4.2.2) (glucose SEQ ID n° 7461 PL-1878.1 1820276 to 84% phosphomutase) (pgm) . [Escherichia

1821916 coli] dbj |BAA35345.l| (D90708)

Phosphoglucomutase (EC 5.4.2.2) (glucose phosphomutase) (pgm) . [Escherichia coli] gb|AAC73782.l| (AE000172) phosphoglucomutase [Escherichia coli K12] SEQ ID n~a003

TABL AU II

sp|P36658|SEQA_ΞCOLI SΞQA PROTEIN pir] |A54296 seqA protein - Escherichia coli gb | AAA19855. l] (U07651) SeqA [Escherichia coli]_

Contig9 from dbj |BAA35336.l| (D90707) SeqA protein. SΞQ ID n° 7462 PL-3924.1 1821978 to 773

[Escherichia coli] db [BAA35344.1 | (D90708)

1822502

SeqA protein. [Escherichia coli] gb| AAC73781.1]

(AE000172) négative modulator of initiation of réplication [Escherichia coli K12] SEQ ID n~3087 sp|P46880|HXKG_ΞCOLI GLUCOKINASE (GLUCOSE

KINASE) pir||A65013 glucokmase (EC 2.7.1.2) -

Ξscherichia coli (strain K-12) gb| ÀAC75447. l|

Contig9 from (AE000327) glucokmase [Escherichia coli K12] SEQ ID n° 7463 PL-1879.1 1823289 to m 763 dbj |BAA16258.l| (D90868) GLUCOKINASE (EC

1824254 2.7.1.2). [Escherichia coli] dbj |BAA16261. l|

(D90869) GLUCOKINASE (EC 2.7.1.2). [Escherichia coli] gb|AAG57514.l|AE005470_l (AΞ005470) glucokinase [Escherichia coli 015-7 :H7] SEQ ID n~î004

Contig9 from SEQ ID n° 7464 PL-6510.1 1825140 to m No Hits found

1825247 #N/A Contig9 from SEQ ID n° 7465 PL-6509.1 1825578 to No Hits found

1825745 #N/A Contig9 from SEQ ID n° 7466 PL-6508.1 1825736 to No Hits found

1825909 #N/A pir| JΞ82455 conserved hypothetical protein

Contig9 from VCA0469 [imported] - Vibrio cholerae SEQ ID n° 7467 PL-6507.1 1825911 to 503 (group Ol strain N16961) gb| AF96373. l|

1826195 (AΞ004379) conserved hypothetical protein

[Vibrio cholerae] #N/A

Contig9 from SEQ ID n° 7468 PL-3923.1 1826365 to m No Hits found

1826877 SEQ ID n~3086

TABLEAU II

sp|P04805|SYE_ECOLI GLUTAMYL-TRNA SYNTHΞTASΞ

(GLUTAMATE- -TRNA LIGASE) (GLURS) pir||SYECΞT glutamate--tRNA_ ligase (EC 6.1.1.17) -

Ξscherichia coli emb|CAA45391.l| (X63976)

Contig9 from glutamyl-tRNA synthetase [Escherichia coli] SEQ ID n° 7469 PL-1880.1 1827248 to 89% gb|AAA65715.l| (M13687) glutamyl-tRNA synthetase

1828666 [Escherichia coli] gb | AAC75457.1 | (AE000328) glutamate tRNA synthetase, catalytic subunit

[Ξscherichia coli K12] dbj |BAA16272.l| (D90869) glutamate- -tRNA ligase (ΞC 6.1.1.17)

[Escherichia coli] SΞQ ID n~ÏO06

Contig9 from SEQ ID n° 7470 PL-6504.1 1829016 to No Hits found

1829138 #N/A sp|P56604 |YPEB_ECOLI HYPOTHETICAL 8.4 KD PROTEIN

Contig9 from

IN XAPB-LIG INTERGENIC REGION SEQ ID n° 7471 PL-6502.1 1829343 to 46% gb|AAG57529.l|AE005471_6 (AE005471) Z3676 gène

1829558 product [Ξscherichia coli 0157 :H7] #N/A sp|P3303l|NUPC_ΞCOLI NUCLEOSIDE PERMEASE NUPC

(NUCLEOSIDΞ-TRANSPORT SYSTΞM PROTΞIN NUPC) pir| |F65013 nucleoside transport protein nupC -

Contig9 from Escherichia coli gb |AAC75452.l| (AE000327) SEQ ID n° 7472 PL-1881.1 1829642 to 85% permease of transport system for 3 nucléosides

1830826 [Escherichia coli K12] dbj |BAA16263. l| (D90869)

NUCLEOSIDE PERMΞASΞ NUPC (NUCLEOSIDE-TRANSPORT

SYSTEM PROTEIN NUPC) . [Escherichia coli] SEQ ID n~1007 sp|P15042|DNLJ_ECOLI DNA LIGASE

(POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+] )

Contig9 from pir]|LQECC6 DNA ligase (NAD+) (EC 6.5.1.2) - SΞQ ID n° 7473 PL-1882.1 1831187 to m Escherichia coli gb|AAA24070.1] (M24278) DNA

1833205 ligase (EC 6.5.1.2) [Ξscherichia coli] gb|AAC75464.l| (AE000328) DNA ligase

[Escherichia coli K12] SEQ ID n-î.008

TABLEAU II

Contig9 from sp|P77173|ZIPA_ECOLI CELL DIVISION PROTEIN ZIPA SEQ ID n° 7474 PL-1883.1 1833267 to 643 gb|AAB42061.l] (U74650) ZipA [Escherichia coli]

1834178 SEQ ID n~î009 sp ] P12610 | CYSZ_ECOLI CYSZ PROTEIN pir | | BVECCZ probable sulfate transport protein CysZ -

Escherichia coli (strain K-12)

Contig9 from gb|AAC75466.l| (AE000329) required for sulfate

SEQ ID n° 7475 PL-1884.1 1834399 to p 723 transport [Escherichia coli K12]

1835169 gb|AAG57532.l|AE005471_9 (AE005471) required for sulfate transport [Ξscherichia coli

0157 :H7] ^~ SΞQ ID n-1010 pdb|lFCj]A Chain A, Crystal Structure Of Oass

Complexed With Chloride And Sulfate pdb|lFCJ|B Chain B, Crystal Structure Of Oass

Complexed With Chloride And Sulfate pdb|lFCJ|C Chain C, Crystal Structure Of Oass

Contig9 from

Complexed With Chloride And Sulfate SEQ ID n° 7476 PL-1885.1 1835284 to p 893 pdb|lFCJ|D Chain D, Crystal structure Of Oass

1836237

Complexed With Chloride And Sulfate pdb|lOAS|A Chain A, O-Acetylserine Sulfhydrylase

From Salmonella Typhimurium pdb|lOAS|B Chain B,

O-Acetylserine Sulfhydrylase From Salmonella

Typhimurium SΞQ ID n-1011

TABLBAU II

sp]P07006|PTHP_ECOLI PHOSPHOCARRIER PROTEIN HPR

(HISTIDINE-CONTAINING PROTEIN) pir| |WQECPH phosphotransferase system phosphohistidine- containing protein [validated] -

Escherichia coli pir| | WQEBPH phosphotransferase system phosphohistidine-containing protein -

Salmonella typhimurium pdb|lGGR|B Chain B,

Complex Of Enzyme Iiaglc And The Histidine-

Containing Phosphocarrier Protein Hpr

From Ξscherichia Coli Nmr, Restrained

Contig9 from ^{~ ^}Regularized Mean Structure pdb|lPOH| SEQ ID n° 7477 PL-6500.1 1836791 to 923 Phosphotransferase (Histidine-Containing

1837048 Phosphocarrier Protein) (Hpr) pdb|2JΞL|P Chain P, Jel42 FabHPR COMPLΞX pdb|3EZΞ|B Chain B, Complex Of The Ammo

Terminal Domain Of Enzyme I And The

Histidine-Containing Phosphocarrier Protein Hpr

From Bscherichia Coli Nmr, Restrained

Regularized Mean Structure pdb|3ΞZA|B

Chain B, Complex Of The Amino Terminal Domain Of

Enzyme I And The Histidine-Containing

Phosphocarrier Protein Hpr From

Escherichia Coli Nmr, Restrained Regularized #N/A sp | P12654 | PT1_SALTY PHOSPHOENOLPYRUVATE-PROTEIN

PHOSPHOTRANΞFERASΞ (PHOSPHOTRANΞFΞRASΞ

Contig9 from SYSTΞM, ΞNZYMΞ I) pir| |WQEBPI SEQ ID n° 7478 PL-1886.1 1837233 to 873 phosphotransferase System enzyme I (EC 2.7.3.9)

1838960 Salmonella typhimurium gb|AAA27060.l| (M76176) enzyme I [Salmonella typhimurium] SEQ ID n-î.012

TABLEAU II

sp|P08837|PTGA_ECOLI PTS SYSTEM, GLUCOSE- SPECIFIC IIA COMPONENT (EIIA-GLC) (GLUCOSE-PERMEASE IIA COMPONENT) (PHOSPHOTRANSFERASE ENZYMΞ II, A

COMPONΞNT) (EIII-GLC) pir] |WQECP3 phosphotransferase system enzyme II (EC 2.7.1.69), ^{~ ^}glucose-specific, factor III - Escherichia coli gb|AAA2360 .l| (M93578) PTS enzyme III glc [Escherichia coli] gb|AAA23603.l| (M93580) PTS enzyme III glc [Escherichia coli] gb|AAA23604.l| (M93582) PTS

Contig9 from enzyme III glc [Escherichia coli] SEQ ID n° 7479 PL-3921.1 1839009 to 92% gb|AAA23605.l| (M93579) PTS enzyme III glc

1839518 [Ξscherichia coli] gb|AAA23606.l| (M93581) PTS enzyme III glc [Ξscherichia coli] gb|AAA23607.l| (M93594) PTS enzyme III glc [Escherichia coli] gb| AA23608.lj (M93595) PTS enzyme III glc [Escherichia coli] gb|AAA23609.l] (M93597) PTS enzyme III glc [Escherichia coli] gb] AAA23610.l| (M93584) PTS enzyme III glc [Escherichia coli] gb|AAA23611.l| (M93596) PTS enzyme III glc [Escherichia coli] gb] AAA23612.l| (M93587) PTS enzyme III glc [Escherichia coli] gb|AAA23613.l| (M93598) PTS enzyme III glc SΞQ ID n~S085

Contig9 from gb|AAG57539.l|AE005472_6 (AE005472) cysteine

SEQ ID n° 7480 PL-2680.2 1839761 to 743 synthase B, O-acetylεerine sulfhydrolase B

1840642 [Ξscherichia coli 0157 :H7] SEQ ID n~ï877

TABLEAU II

sp|P16676|CYSA_ΞC0LI SULFATΞ TRANSPORT ATP- BINDING PROTEIN CYSA pir | | QRECSA sulfate transport ATP-binding protein cysA - Escherichia coli gb|AAC75475.l| (AE000329) ATP-binding

Contig9 from component of sulfate permease A protein; SEQ ID n° 7481 PL-2679.1 1840781 to m 823 chromate résistance [Escherichia coli K12]

1841869 dbj |BAA16296.l| (D90871) sulfate/thiosulfate transport protein cysA [Escherichia coli] dbj |BAA16305.1 | (D90872) sulfate/thiosulfate transport protein cysA

[Escherichia colil SEQ ID n~î875 sp|P16702]CYSW_ECOLI SULFATE TRANSPORT SYSTEM

PERMEASE PROTEIN CYSW gb] AAA23638.1 | (M32101) sulfate permease [Escherichia coli]

Contig9 from dbj ]BAA16297.1 | (D90871) sulfate/thiosulfate

SEQ ID n° 7482 PL-2678.1 1841884 to 84% transport protein cysW [Escherichia

1842729

COli] dbj |BAA16306.1 | (D90872) sulfate/thiosulfate transport protein cysW

[Ξscherichia coli] SEQ ID n~î874

Contig9 from gb|AAG57542.l|AE005472_9 (AE005472) sulfate,

SEQ ID n° 7483 PL-2677.1 1842729 to 91% thiosulfate transport system permease T protein

1843562 [Escherichia coli 0157 :H7] SΞQ ID n~ï873 sp|P16700|CYSP_ECOLI THIOSULFATΞ-BINDING PROTEIN

PRECURSOR pir| [ JGECT thiosulfate-binding protein cysP precursor - Escherichia coli gb]AAA23636.l] (M32101) thiosulfate binding

Contig9 from protein [Escherichia coli] gb| AAC75478. l| SEQ ID n° 7484 PL-2676.1 1843562 to m 793 (AEO 00330) thiosulfate binding protein

1844584 [Ξscherichia coli K12] dbj |BAA16299.1 | (D90871) thiosulfate-binding protein cysP precursor

[Ξscherichia coli] dbj |BAA16308.1 |

(D90872) thiosulfate-binding protein cysP precursor [Escherichia coli] SΞQ ID n~2872

TABLΞAU II

sp|P76537|YFEY__ΞCOLI HYPOTHETICAL 20.9 KDA

PROTEIN IN UCPA-AMIA INTΞRGENIC REGION

Contig9 from PRECURSOR pir| |G65017 hypothetical protein SΞQ ID n° 7485 PL-2675.1 1844952 to 603 b2432 - Escherichia coli (strain K-12)

1845560 gb|AAC75485.l| (AE000330) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~£871 sp|P52083|YGIW_ECOLI PROTEIN YGIW PRECURSOR pir| |F65089 ygi protein precursor - Escherichia

Contig9 from coli gb|AAA69192.l| (U28377) ORF_fl30 SEQ ID n° 7486 PL-3919.1 1845732 to 573 [Escherichia coli] gb| AAC76060.1 | (AE000384)

1846151 orf, hypothetical protein [Escherichia coli K12] gb|AAG58158.l|AE005532_2 (AE005532) orf, hypothetical protem [Escherichia coli 0157 :H7] SEQ ID n~3083

Contig9 from gb|AAG57552.1 AE005473_7 (AE005473) Z3699 gène

SΞQ ID n° 7487 PL-3918.1 1846276 to 74% product [Escherichia coli 0157 :H7]

1846707 SΞQ ID n~3082

Contig9 from gb|AAG57554.l|AΞ005474_2 (AΞ005474)

SEQ ID n° 7488 PL-2674.1 1846845 to 81% coproporphyrinogen III oxidase [Ξscherichia coli

1847753 0157 :H7] SΞQ ID n~1870 sp|Q99132]pRTl_ΞRWCA EXTRACELLULAR

METALLOPROTEASE PRECURSOR pir| |A41048

Contig9 from extracellular metalloproteinase (ΞC 3.4.24.-) SEQ ID n° 7489 PL-2673.1 1847986 to 64% precursor - Erwinia carotovora subsp .

1849083 carotovora gb| AAA24858.l| (M36651) extracellular protease (prt) [Pectobacterium carotovorum] SEQ ID n~1869

Contig9 from

SEQ ID n° 7490 PL-6497.1 1849244 to No Hits found

1849561 #N/A

Contig9 from sp|P77254|ΞNGA_ΞC0LI PROBABLΞ GTP-BINDING

SEQ ID n° 7491 PL-2672.1 1849586 to 893 PROTΞIN ΞNGA

1851067 SΞQ ID n~î868

Contig9 from gb[AAG31169.l| (AF314961) unknown [Salmonella

SEQ ID n° 7492 PL-2671.1 1851358 to 813 typhimurium]

1852530 SΞQ ID n~S867

TABL AU II

ContigS from gb|AAG57623.l|AE005480_10 (AE005480) orf, SEQ ID n° 7493 PL-2670.1 1852545 to 663 hypothetical protein [Escherichia coli 0157 :H7]

1853165 SΞQ ID n~î866 sp | 04804 | SYH_ECOLI HISTIDYL-TRNÂ^{^}SYNTHETASE (HISTIDINE- -TRNA LIGASE) (HISRS) pir||SYECH histidine- -tRNA ligase (EC 6.1.1.21) [validated] - Escherichia coli pdb | IKMM c Chain C, Histidyl- Trna Synthetase Complexed With Histidyl- Adenylate pdb|lKMM|A Chain A, Histidyl-Trna Synthetase Complexed ith Histidyl-Adenylate pdb|lKMN|c Chain C, Histidyl-Trna Synthetase Complexed With Hisfidinol And Atp pdb[lKMN|A Chain A, Histidyl-Trna Synthetase complexed ith

Contig9 from Hisfidinol And Atp pdb | IKMM |B Chain B, Histidyl- SEQ ID n° 7494 PL-2669.1 1853177 to m 863 Trna Synthetase Complexed With Histidyl-

1854454 Adenylate pdb|lKMM|D Chain D, Histidyl-Trna Synthetase Complexed with Histidyl-Adenylate pdb|lKMN|B Chain B, Histidyl-Trna Synthetase Complexed With Hisfidinol And Atp pdb|lKMN|D Chain D, Histidyl-Trna Synthetase Complexed With Hisfidinol And Atp gb|AAA03226.l| (M11843) histidine-tRNA synthetase [Escherichia coli] gb|AAC75567.l| (AE000337) histidine tRNA synthetase [Escherichia coli K12] dbj |BAA16401.l| (D90880) histidine- -tRNA ligase (EC 6.1.1.21) [Escherichia coli] SΞQ ID n~3L864

Contig9 from sp|P7224l|GCPE_PR0ST GCPΞ PROTEIN HOMOLOG

SEQ ID n° 7495 PL-2668.1 1854573 to m 843 gb|AAB51469.l| (U67933) AarC [Providencia

1855694 stuartii] SΞQ ID n~i863

Contig9 from gb|AAG57626.l|AE005481_2 (AE005481) putative

SEQ ID n° 7496 PL-2667.1 1855768 to 593 membrane protein [Escherichia coli 0157 :H7]

1856808 SEQ ID n~£862

TABLEAU II

pir||F82178 probable fimbrial biogenesis and

Co SEQ ID n° 7497 PL-3917.1 1

putative [Vibrio cholerae] SΞQ ID n~3081

Sp]P36S79|YFGB_EC0LI HYPOTHETICAL 43.1 KDA

PROTEIN IN NDK-GCPE INTERGENIC REGION pir] |D65028 hypothetical 43.1 kD protein in ndk- gcpE intergenic région - Escherichia coli (strain K-12) gb|AAA2l359.l| (U029^~65)

Contig9 from unknown [Escherichia coli] gb| AAC75570.1 |

SEQ ID n° 7498 PL-2666.1 1857448 to m 863

(AE000338) orf, hypothetical protein

1858626

[Escherichia coli K12] dbj |BAA16404.l| (D90881) similar to [SwissProt Accession Number P36979]

[Escherichia coli] dbj | BAA16408.1 | (D90882) similar to [SwissProt Accession Number P36979] [Escherichia coli] SΞQ ID n~SL861

Contig9 from gb]AAA93513.l] (L37442) thymidylate : zeocin SEQ ID n° 7499 PL-3916.1 1858809 to m 74% résistance protein :NDP kinase fusion

1859234 protein [Cloning vector pZEO-SG4] SΞQ ID n~3080 sp|P76577 |PBPC_ECOLI BIFUNCTIONAL PENICILLIN- BINDING PROTEIN 1C PRECURSOR (PBP-1C) pir| ]F65028 hypothetical protein b25l9 -

Contig9 from Escherichia coli (strain K-12) gb|AAC75572.1] SEQ ID n° 7500 PL-2664.1 1859454 to m 723

(AE000338) putative peptidoglycan enzyme

1861775

[Escherichia coli K12] gb|AAB48052.l| (U88571) bifunctional penicillin-binding protein 1C

[Escherichia coli] SΞQ ID n~£860

Contig9 from gb|AAG57634.l|AE005482_l (AE005482) orf, SEQ ID n° 7501 PL-2663.1 1861832 to m 72% hypothetical protein [Escherichia coli 0157 :H7]

1866862 SEQ ID n-î.859 pir| |G75120 hypothetical protein PAB0518 -

Contig9 from

Pyrococcus abyssi (strain Orsay) SEQ ID n° 7502 PL-2662.1 1868104 to m 49% emb|CAB49680.l| (AJ248285) hypothetical protein

1868904

[Pyrococcus abyssi] SEQ ID n-2.858

TABLEAU II

pir| |F82543 outer membrane hemolysin activator

Co SEQ ID n° 7503 PL-2661.1 1

XF21S6 [imported] - Xylella

Contig9 from fastidiosa (strain 9a5c) SEQ ID n° 7504 PL-2660.1 1872201 to 46% gb|AAF84995.1 | AΞ004032_14 (AΞ004032)

1881086 hemagglutinin-rike secreted protein [Xylella fastidiosa] SΞQ ID n~ï856

Contig9 from SEQ ID n° 7505 PL-6921.1 1881788 to No Hits found

1882600 #N/A Contig9 from SEQ ID n° 7506 PL-7430.1 1882597 to No Hits found

1882914 #N/A sp|P39394|YJIW_ΞCOLI HYPOTHΞTICAL 14.6 KDA

PROTEIN IN MCRB-HSDS INTERGENIC REGION

(F132) pir| ]S56573 hypothetical 14.6K protein

Contig9 from

(mcrB-hsdS intergenic région) - SEQ ID n° 7507 PL-7429.1 1882959 to 38%

Escherichia coli gb|AAA97244.1 | (U14003)

1883201

ORF_fl32 [Escherichia coli] gb|AAC77303.l|

(AE000505) orf, hypothetical protein

[Escherichia coli K12] #N/A sp|034419|RSRl_VIBCH CRYPTIC PHAGE CTXPHI

TRANSCRIPTIONAL REPRESSOR RSTR pir | |H82197 transcription repressor RstR VC1464 VC1455

[imported] - Vibrio cholerae (group

Contig9 from

01 strain N16961) gb |AAB81724.1 | (U83795) RstR

SEQ ID n° 7508 PL-6485.1 1883294 to 48%

[Vibrio cholerae] gb |AAB81728.1 | (U83796) RstR

1883665

[Vibrio cholerae] gb| AAF94612. l| (AΞ004224) transcriptional repressor RstR [Vibrio cholerae] gb|AAF94621.l] (AΞ004224) transcriptional repressor RstR [ ibrio cholerae] #N/A

TABLΞAU II

Contig9 from dbj |BAB05094.l| (AP001511) DNA primase [Bacillus

SΞQ ID n° 7509 PL-4048.2 1883765 to 37% halodurans]

1884193 #N/A

Contig9 from pdb|lF3l|A Chain A, Crystal Structure Of Tn5

SEQ ID n° 7510 PL-3161.1 1884204 to 573 Transposase Complexed With Transposon

1885586 End Dna SEQ ID n~2408

Contig9 from sp| 067465 |PRIM_AQUAE DNA PRIMASE 3ir| |G70429

SEQ ID n° 7511 PL-3160.2 1885620 to 11% DNA primase Aquifex aeolicus gb|AAC07430.l|

1888583 (AE000743) DNA primase [Aquifex aeolicus] #N/A

Contig9 from gb|AAF89876.ι | (AF173869) putative site-specific

SEQ ID n° 7512 PL-3158.1 1888570 to 313 recombinase XerD [Staphylococcus

1889700 aureus] SEQ ID n~2404

Contig9 from

SEQ ID n° 7513 PL-6926.1 1890255 to p No Hits found

1890521 #N/A

ContigS from

SEQ ID n° 7514 PL-4051.1 1890543 to p No Hits found

1891010 SEQ ID n~3197

Contig9 from

SEQ ID n° 7515 PL-6474.1 1891060 to p No Hits found

1891371 #N/A

Contig9 from

SEQ ID n° 7516 PL-4052.1 1891368 to p No Hits found

1891823 SEQ ID n~S198

Contig9 from

SEQ ID n° 7517 PL-6473.1 1891864 to p No Hits found

1891995 #N/A

Contig9 from

SEQ ID n° 7518 PL-3188.1 1892043 to p No Hits found

1892699 SEQ ID n-2437 pir| |B81207 hypothetical protein NMB0372

Contig9 from [imported] - Neisseria meningitidis SEQ ID n° 7519 PL-6471.1 1892973 to p 41% (group B strain MD58) gb|AAF40814.l] (AE002393)

1893320 hypothetical protein [Neisseria meningitidis

MC58] #N/A

m en en oo r- r r

^ ^•^ ! ^•^ 1 !

Ï5 S » , £ a ^β α

# # * o Q P Q H H i α α α a

H m H

^EQID

^•d ^•d ^•d q q a a a a a o 0 0 0 0 m m m Ή m w ω ω tn

-H

M W M ffi K

_°\_° *>

O 0 o O O n en a 1-5 a a la ro ro •* ft ft ft ft ft e B 6 e ε g

0 e Ë e

0 0 0 o O 0 o 0 O 0 0 o o 0 0 0 0 0 0

M en o H o o r- en en en en o r- o en n en H en ro en en en o ro c o o ro in en r en en en en ro en r-- tn r en tn ro tn n tn en tn en tn o tn q> co tn o ro ro eo en en tn e t'-ri ro en H ' en en oo H en en en oo en en en en -ri en H en en H en H

O 0 O o 0 o w o O o O

U u U U U u u u u U

n o m o en ro o H H en en en en en o o oo o

» J

D< P< ft ft ft ft ft ft ft o H ro r- en m m r

§

Q Q Q O Q Q Q Q Q

H

1 σ o a α m α σ O w M H H W M to tn ω w ra TABLEAU II

ContigS from gb|AAD21057.l| (AF119150) RtxA protein [Vibrio SEQ ID n° 7530 PL-2590.1 1S33706 to m 52%

1S38832 cholerae]

SEQ ID n~1783 pir| |C82199 RTX toxin RtxA VC1451 [imported] -

Contig9 from

Vibrio cholerae (group 01 strain SEQ ID n° 7531 PL-2588.1 1938888 to m 78%

N16961) gb|AAF94608.l| AE004223) RTX toxin 1944743

RtxA [Vibrio cholerae] SEQ ID n~î780 pir| |F75337 transposase - Deinococcus

Contig9 from radiodurans (strain RI) SEQ ID n° 7532 PL-4003.1 1945353 to m 62% gb|AAF11477.l|AE002031_6 (AΞ002031) transposase

1945781 - - -

[Deinococcus radiodurans] SΞQ ID n~3158 pir||C82199 RTX toxin RtxA VC1451 [imported] -

Contig9 from

Vibrio cholerae (group 01 strain SEQ ID n° 7533 PL-3038.3 1946045 to m 38%

N16961) gb|AAF94608.l| (AE004223) RTX toxin

1956109

RtxA [Vibrio cholerae] #N/A pir| |C82199 RTX toxin RtxA VC1451 [imported] -

Contig9 from

Vibrio cholerae (group 01 strain SΞQ ID n° 7534 PL-3039.1 1956110 to m 64%

N16961) gb|AAF94608.l| (AE004223) RTX toxin

1957099

RtxA [Vibrio cholerae] SΞQ ID n~2272 sp | Q9X4W3 | TXC_VIBCH CYTOLYSIN-ACTIVATING LYSINE-

ACYLTRANSFΞRASΞ RTXC pir| |B82199 RTX toxin

Contig9 from activating protein VC1450 [imported] - Vibrio SEQ ID n° 7535 PL-3888.1 1957217 to m 8 ? cholerae (group 01 strain N16961)

1957678 gb|AAD2l058.l| (AF119150) RtxC protein [Vibrio cholerae] gb|AAF94607.1 | (AE004223) RTX toxin activating protein [Vibrio cholerae] SEQ ID n~3057 pir| |A82199 hypothetical protein VC1449

Contig9 from

[imported] - Vibrio cholerae (group 01 SEQ ID n° 7536 PL-6805.1 1957700 to m 66%

Strain N16961) gb |AAF94606.1 | (AE004223)

1958065 hypothetical protein [Vibrio cholerae] #N/A pir] |H82198 RTX toxin transporter VC1448

ContigS from

[imported] - Vibrio cholerae (group SEQ ID n° 7537 PL-3040.1 1958373 to p 83%

01 strain N16961) gb | AAF94605.1 | (AE004223) RTX

1960478 toxin transporter [Vibrio cholerae] SΞQ ID n~2274

TABLEAU II

pir| |G82198 RTX toxin transporter VC14 7

[imported] - Vibrio cholerae (group

Contig9 from

01 strain N16961) gb|AAD21060. l| (AF119150) SΞQ ID n° 7538- PL-304-1.1 1960471 to p 79?

RtxD protein [Vibrio cholerae] gb|AAF94604. l|

1961826

(AE004223) RTX toxin transporter [Vibrio cholerae] SEQ ID n~2275 pir] [F82198 probable toxin secretion transporter

Contig9 from VC1446 [imported] - Vibrio cholerae SΞQ ID n° 7539 PL-3042.1 1961829 to 83? (group 01 strain N16961) gb | AAF94603.1 |

1963979 (AEO04223) toxin secretion transporter, putative

[Vibrio cholerae] SEQ ID n~2276 pir| |F83090 probable transcription regulator

PA4436 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SΞQ ID n° 7540 PL-3043.1 1964329 to 43% gb|AAG07824.l|AE004858_2 (AE004858) probable

1965135 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~2277 sp|P75735|YBFE_ΞCOLI HYPOTHΞTICAL 13.9 KDA

PROTΞIN IN FLDA-SΞQA INTΞRGENIC REGION pir] |D64803 ybfE protein - Ξscherichia coli gb|AAC73779.l| (AE000172) orf, hypothetical

Contig9 from protein [Escherichia coli 12] dbj |BAA35334.1 | SΞQ ID n° 7541 PL- 6803.1 1965274 to 67?

(D90707) ORF_ID:ol73#3 [Ξscherichia coli]

1965561 dbj |BAA35342.l| (D90708) ORF_ID:θl73#3

[Escherichia coli] gb|AAG55008 ,l| AE005246_8

(AEO05246) orf, hypothetical protein

[Escherichia coli 0157 :H7] #N/A sp|P23243]FLAV_ΞCOLI FLAVODOXIN 1 pir||A37319 flavodoxin A - Ξscherichia coli gb| AAA23789.1 |

(M59426) flavodoxin [Escherichia coli]

Contig9 from dbj [BAA35333.l| (D90707) Flavodoxin. SEQ ID n° 7542 PL-3887.1 1965736 to 85% [Escherichia coli] dbj |BAA35341.1 | (D90708)

1966266 Flavodoxin. [Ξscherichia coli] gb|AAC73778. lj

(AΞ000172) flavodoxin 1 [Ξscherichia coli K12] gb|AAG55007.l|AE005246_7 (AE005246) flavodoxin 1

[Ξscherichia coli 0157 :H7] SEQ ID n~3056

TABLΞAU II

Contig9 from gb|AAD01582.l| (AF016035) ferrie uptake SEQ ID n° 7543 PL-6800.1 1966632 to 92% régulation protein [Pectobacterium

1967078 __ _jhrysanthemi] #N/A pir| |G82603 conserved hypothetical protein

Contig9 from XF2080 [imported] - Xylella fastidiosa SEQ ID n° 7544 PL-6799.1 1967177 to 71% (strain 9a5c) gb|AAF84879.l|AE004023_15

1967458 (AE004023) conserved hypothetical protein

[Xylella fastidiosa] #N/A pir|]H82603 DNA-damage-inducible protein XF2081

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 7545 PL-6798.1 1967445 to m 72? (Strain Sa5c) gb| AAF84880.l[AE004023_16

1967708 (AE004023) DNA-damage-inducible protein [Xylella fastidiosa] #N/A sp|Q54468 |CHB_SERMA CHITOBIASE PRECURSOR (N-

ACETYL-BETA-GLUCOSAMINIDASΞ) (BETA-N-

Contig9 from

ACΞTYLHΞXOSAMINIDASE) pir| | JC4732 beta-N- SEQ ID n° 7546 PL-3044.1 1968029 to m 78? acetylhexosaminidase (EC 3.2.1.52) - Serratia

1970704 marcescens gb] AB03808.1 | (L43594) N-acetyl- beta-D-glucosammidase [Serratia marcescens] SEQ ID n~2278

Contig9 from dbj |BAB05723.l| (AP001514) gentisate 1,2- SEQ ID n° 7547 PL-3886.1 1971398 to m 30? dioxygenase [Bacillus halodurans]

1971847 SEQ ID n~3055 Contig9 from emb|CAA51370.1] (X72850) 2. -dihydroxybenzoate SEQ ID n° 7548 PL-3045.1 1972465 to m 53% monooxygenase [Sphingomonas sp . ]

1974132 SEQ ID n~2279 Contig9 from SEQ ID n° 7549 PL-6795.1 1974698 to m No Hits found

1975054 #N/A Contig9 from SEQ ID n° 7550 PL-2971.2 1975675 to m No Hits found

1976439 SEQ ID n~2197

TABLEAU II

pir| |D83357 probable transcription regulator

PA2316 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl)

SEQ ID n°-7551 PL-2970.1 1976889 to 68? gb|AAG05704.l|AE004657_ll (AE004657) probable

1977782 transcriptional regulator [Pseudomonas aeruginosa] SΞQ ID n~2196 sp | P00962 | SYQ_EC0LI GLUTAMINYL-TRNA ^{^}SYNTÎÎΞTASE

(GLUTAMINE--TRNA LIGASΞ) (GLNRS) pir | | SYΞCQT glutamine- -tRNA ligase (EC 6.1.1.18) [validated]

- Escherichia coli emb | CAA24894.1 | (V01575)

ContigS from glutaminyl-tRNA synthetase precursor

SEQ ID n° 7552 PL-2969.1 1977952 to m 87?

[Escherichia coli] gb|AAC73774.1 | (AΞ000171) 1979619 glutamine tRNA synthetase [Ξscherichia coli K12] dbj |BAA35328.l| (D90707) Glutaminyl-tRNA synthetase (ΞC 6.1.1.18) (glutamine-tRNA ligase) (GlnRS) . [Escherichia coli] SEQ ID n~2194 pir| |F82254 PTS system, N-acetylglucosamine- specific IIABC component VC0995

Contig9 from

[imported] - Vibrio cholerae (group 01 strain SEQ ID n° 7553 PL-2968.1 1980670 to p 67?

N16961) gb|AAF94156.l| (AE004181) PTS System, N

1982184 acetylglucosamine-spécifie IIABC component

[Vibrio cholerae] SΞQ ID n~2193

TABLEAU II

sp | P09375 |NAGB_ΞC0LI GLUC0SAMINE-6-PH0SPHATΞ

ISOMΞRASΞ (GLUCOSAMINΞ-6-PHOSPHATΞ

DΞAMINASΞ) (GNPDA) (GLCN6P DΞAMINASΞ) pir| |MUECNG glucosamine-6-phosphate isomerase

(ΞC 5.3.1.10) - Escherichia coli pdb|lDEA|A

Chain A, Mol_id: 1; Molécule: Glucosamine 6-

Phosphate Deaminase; Chain: A, B; Ec:

5.3.1.10; Engineered: Yes; Heterogen:

Inorganic Phosphate pdb|lDEA|B Chain B, Mol_id:

1; Molécule: Glucosamine 6-Phosphate Deaminase;

Contig9 from Chain: A, B; Ec: 5.3.1.10; Engineered: Yes; SEQ ID n° 7554 PL-2967.2 1982462 to 85? Heterogen: Inorganic Phosphate

1S83274 pdb|lCD5(A Chain A, Glucosamine-6-Phosphate

Deaminase From E.Coli, T Conformer pdb | IHO | A

Chain A, Glucosamine 6-Phosphate Deaminase

Complexed With The Allosteric

Activator N-Acetyl-Glucosamine-6-Phosphate pdb | IHOT |B Chain B, Glucosamine 6-Phosphate

Deaminase Complexed With The Allosteric Activator N-Acetyl-Glucosamine-6-

Phosphate pdb|lHOR|A Chain A, Mol_id: 1;

Molécule: Glucosamine 6-Phosphate Deaminase;

Chain: A, B; Ec: 5.3.1.10; Engineered: Yes; SEQ ID n~21S2

TABLEAU II

sp | P15300 | NAGA_ΞCOLI N-ACETYLGLUCOSAMINE-6-

PHOSPHATE DEACΞTYLASΞ (GLCNAC 6-P

DEACETYLASE) pir| ] A37018 N-acetylglucosamine-6- phosphate deacetylase (EC 3.5.1.25) - Escherichia coli emb]CAA32353. l| (X14135) nagA gène product (AA 1-382) [Escherichia coli] dbj |BAA35320.1] (D90706) N-acetylglucosamme-6- phosphate deacetylase (EC 3.5.1.25)

ContigS from (NagA) [Ξscherichia coli] dbj |BAA35325.l|

SΞQ ID n° 7555 PL-2966.2 1983359 to 77? (D90707) N-acetylglucosamine-6-phosphate 1984519 ^{~ ""} deacetylase (EC 3- 5.1.25) (NagA)

[Escherichia coli] gb| AAC73771.l| (AΞ000171) N- acetylglucosamine-6-phosphate deacetylase

[Escherichia coli K12] gb|AAC09325.1 | (AF052007) N-acetylglucosamine-6- phosphate deacetylase [Ξscherichia coli] gb|AAG54999.l[AE005245_8 (AE005245) N- acetylglucosamine-6-phosphate deacetylase

[Escherichia coli 0157 :H7] SEQ ID n~2191 sp [ P15301 |NAGC_ECOLI N-ACETYLGLUCOSAMINΞ

REPRESSOR pir|]C64802 N-acetylglucosamine repressor - Escherichia coli dbj |BAA35319.1 |

(D90706) N-acetylglucosamine repressor.

[Escherichia coli] dbj |BAA35324.1 | (D90707) N- acetylglucosamine repressor. [Escherichia coli]

Contig9 from gb|AAC73770.l| (AE000171) transcriptional SΞQ ID n° 7556 PL-2965.1 1984535 to 85? repressor of nag (N-acetylglucosamine)

1S85758 operon [Ξscherichia coli K12] gb| AAC09326.1]

(AF052007) N-acetylglucosamine repressor

[Ξscherichia coli] gb|AAG54998.1 [AΞ005245_7

(AEO05245) transcriptional repressor of nag (N- acetylglucosa ine) operon

[Ξscherichia coli 0157 :H7] SEQ ID n~2190

Contig9 from pir| |Ξ64801 hypothetical protein b0663 -

SΞQ ID n° 7557 PL-6789.1 1986096 to m 33? Escherichia coli gb |AAC73764.l| (AE000170)

1986260 putative RNA [Ξscherichia coli K12] #N/A

TABLEAU II

Contig9 from gb|AAG54995.l|AE005245_4 (AE005245) orf, SΞQ ID n° 7558 PL-2964.1 1986755 to m 63? hypothetical protein [Escherichia coli θl57:H7]

1987936 _.SEQ ID n~2189 Contig9 from emb|CAB62263.l| (AJ249116) MiaB protein SEQ ID n° 7559 PL-2963.1 1988135 to p 91? [Salmonella typhimurium]

1989565 SEQ ID n~2188 Contig9 from emb|CAB62264.l| (AJ249116) YbeZ protein SEQ ID n° 7560 PL-2962.1 1989581 to p 90? [Salmonella typhimurium]

1990630 SΞQ ID n~2187 sp|P77385]YBEY_ΞCOLI HYPOTHΞTICAL 17.5 KDA

PROTEIN IN CUTE-CORC INTERGENIC REGION pir| |A64801 ybeY protein - Escherichia coli

ContigS from gb|AAB40861.l| (U82598) HI0004 homolog SEQ ID n° 7561 PL-3885.1 1990627 to p 83?

[Escherichia coli] gb| AC73760.1 | (AE000170)

1991094 orf, hypothetical protein [Escherichia coli K12] dbj |BAA35314.l| (D90706) Hypothetical protein

HI0004 [Escherichia coli] SΞQ ID n~3054 sp|P77392|YBEX_ΞCOLI HYPOTHΞTICAL 33.3 KDA

PROTEIN IN CUTE-ASNB INTERGΞNIC RΞGION pir] |H64800 ybeX protein - Ξscherichia coli

Contig9 from gb|AAB40860.l| (U82598) similar to H. influenzae SEQ ID n° 7562 PL-2961.1 1991167 to 91? [Ξscherichia coli] gb| AC73759.1 | (AE000170)

1992048 putative transport protein [Ξscherichia coli

K12] gb|AAG54991.l|AE005244_9 (AΞ005244) putative transport protein [Ξscherichia coli

0157.-H7] SEQ ID n~2186

Contig9 from gb|AAD09824.l| (AF116773) apolipoprotein N-

SEQ ID n° 7563 PL-2960.1 1992056 to 77% acyltransferase [Salmonella

1993585 typhimurium] SEQ ID n~2185

Contig9 from dbj |BAA35307.l| (D90705) Hypothtical protein in

SEQ ID n° 7564 PL-2959.1 1994148 to 75% gltJ 5 ' région . [Ξscherichia coli]

1995041 SEQ ID n~2183

TABLΞAU II

sp | P41074 | GLTJ_ECOLI GLUTAMATE/ASPARTATE

TRANSPORT SYSTEM PERMEASE PROTEIN GLTJ pir] |D64800 glutamate/aspartate transport protein gltJ - Ξscherichia coli gb|AAA60980.l|

(U10981) GltJ [Escherichia coli]

Contig9 from dbj |BAA35306.l| (D90705) Glutamate/aspartate

SEQ ID n° 7565 PL-2958.1 ^" 1995Ï74^~to 79? transport system permease protein

1995914 gltJ. [Ξscherichia coli] gb| AB40855.1 |

(U82598) glutamate/aspartate transport System permease protein [Escherichia coli] gb|AAC73755.l| (AE000169) glutamate/aspartate transport system permease

[Escherichia coli K12] SEQ ID n~2182 sp | P 1075 | GLTK_ECOLI GLUTAMATE/ASPARTATE

TRANSPORT SYSTEM PERMEASE PROTEIN GLTK pir||c64800 glutamate/aspartate transport protein gltK - Escherichia coli gb| AAA60981.1 |

(U10S81) GltK [Escherichia coli] dbj |BAA35305.l| (DS0705) Glutamate/aspartate

Contig9 from transport system permease protein

SEQ ID n° 7566 PL-2957.1 1995915 to 91? gltK. [Escherichia coli] gb | AAB40854.1 |

1996589 (U82598) glutamate/aspartate transport system permease protein [Ξscherichia coli] gb|AAC73754.l| (AE000169) glutamate/aspartate transport system permease

[Escherichia coli K12] gb|AAG54987.l| AE005244_5

(AE005244) glutamate/aspartate transport system permease [Escherichia coli 0157 :H7] SΞQ ID n~2181

TABLEAU II

sp | 41076 |GLTL_ΞCOLI GLUTAMATE/ASPARTATE TRANSPORT ATP-BINDING PROTEIN GLTL pir| |B64800 glutamate/aspartate transport protein gltL -

Escherichia coli gb| AAA60982.l| (U10981) GltL

[Escherichia coli] dbj |BAA35304.l| (D90705)

Glutamate/aspartate transport atp-binding

Contig9 from protein gltL. [Ξscherichia coli] SEQ ID n° 7567 PL-2956.1 1996589 to 90? gb|AAB40853. l| (U82598) glutamate/aspartate

1997314 transport ATP-bindmg protein [Escherichia coli] gb| AAC73753.1 | (AE000169)

ATP-binding protein of glutamate/aspartate transport system [Escherichia coli

K12] gb[AAG54986.l]AE005244_4 (AE005244) ATP- binding protein of glutamate/aspartate transport system [Escherichia coli 0157.-H7] SEQ ID n~ 180

Contig9 from gb|AAG54976.l|AΞ005243_5 (AΞ005243) leucine tRNA SΞQ ID n° 7568 PL-2S55.1 1997477 to p 8c synthetase [Escherichia coli 0157.-H7]

2000059 SEQ ID n~ 179 sp|P1010l|RLPB_ECOLI RARΞ LIPOPROTΞIN B

PRECURSOR pir] | PECRB lipoprotein rlpB precursor - Escherichia coli dbj |BAA35288.l|

Contig9 from

(D90704) Lipoprotein rlpB precursor. SEQ ID n° 7569 PL-3883.1 2000073 to p 63%

[Escherichia coli] gb| AAB40842.1 | (U82598)

2000621 lipoprotein B precursor [Escherichia coli] gb|AAC73742. l| (AE000168) a minor lipoprotein

[Escherichia coli K12] SEQ ID n~3053

TABLEAU II

sp|P28630|HOLA_ECOLI DNA POLYMERASE III, DELTA SUBUNIT pir| |A45251 DNA-directed DNA polymerase

(EC 2.7.7.7) III delta chain - __

Escherichia coli gb| AAA23675.l| (L04576) DNA polymerase III delta subunit [Escherichia coli]

Contig9 from gb|AAB59047.l| (M94267) DNA polymerase III delta

SEQ ID n° 7570 PL-2954.1 2000618 to 72? subunit ^'[Escherichia coli] dbj |BAA35287.l]

2001658 (D90704) DNA-directed DNA polymerase (EC

2,7.7.7) III delta chain [Escherichia coli] gb|AAB40841.l| (U82598) DNA-directed DNA polymeraselll delta chain [Ξscherichia coli] gb|AAC73741.l| (AE000168) DNA polymerase

III, delta subunit [Ξscherichia coli K12] SΞQ ID n~217E

ContigS from gb|AAG54973.l|AE005243_2 (AE005243) orf, SEQ ID n° 7571 PL-2S53.1 2001642 to 63? hypothetical protein [Escherichia coli 0157:H7]

2002319 SEQ ID n~2177

Sp|P05848 ]YBEB_ECOLI HYPOTHETICAL 11.6 KDA

Contig9 from

PROTEIN IN MRDA-PHPB INTERGΞNIC REGION SEQ ID n° 7572 PL-6782.1 2002427 to 86? gb|AAB40837.l| (U82598) HI0034 homolog

2002744

[Escherichia coli] #N/A sp|P05850 |YBEA_ECOLI HYPOTHΞTICAL 17.3 KDA

PROTEIN IN MRDA-PHPB INTERGENIC RΞGION pir| |QQΞCP1 ybeA protein - Ξscherichia coli emb|CAA28200.l| (X04516) ORF2 (AA 1-155) [Escherichia coli] gb|AAB40836.1 | (U82598)

Contig9 from hypothetical protein [Escherichia coli] SEQ ID n° 7573 PL-3882.1 2002747 to 81? gb|AAC73737.l| (AE000168) orf, hypothetical

2003217 protein [Escherichia coli K12] dbj |BAA35283.l|

(D90704) Hypothetical 17k protein (pbpA 5' région) [Ξscherichia coli] gb|AAG54970.l|AE005242_14 (AΞ005242) orf, hypothetical protein [Ξscherichia coli 0157 :H7] SEQ ID n~3052

TABLEAU II

sp|P0815θ|PBP2_ECOLI PENICILLIN-BINDING PROTEIN

2 (PBP-2) pir||ZPECP2 penicillin-binding protein 2 - Escherichia__coli emb|CAA2820l.l|

(X04516) penicillin-binding protein 2 (PBP2)

[Escherichia coli] dbj |BAA35282. i | (D90704)

Penicillin-binding protein 2 (pbp-2) .

Contig9 from [Escherichia coli] gb| AB40835.l| (U82598) SEQ ID n° 7574 PL-2952.1 2003258 to p 84? penicillin-binding protein 2 [Escherichia coli]

2005153 gb|AAC73736.l| (AΞ000168) cell elongation, e phase,- peptidoglycan synthetase,- penicillin-bindïhg protein 2 [Escherichia coli

K12] gb|AAG54969.l|AE005242_13 (AΞ005242) cell elongation, e phase; peptidoglycan synthetase; penicillin-binding protein 2 [Escherichia coli

0157:H7] SEQ ID n~2176 sp|P15035|RODA_ECOLI ROD SHAPE-DΞTΞRMINING

PROTEIN RODA pir| |BVΞCRD rod shape-determining protein mrdB - Escherichia coli gb|AAA2457i.ι|

(M22857) rod-shape-determining protein [Escherichia coli] dbj |BAA35277.l| (D90703) Rod shape-determining protein MrdB. [Escherichia coli] gb|AAB40834.l| (U82598) rod-shape-

Contig9 from determining protein [Ξscherichia coli]

SEQ ID n° 7575 PL-2951.1 2005162 to 90% gb|AAC73735.l| (AΞ000168) rod shape-determining

2006274 membrane protein; sensitivity to radiation and drugs [Ξscherichia coli K12] dbj |BAA35 81.1 | (D90704) Rod shape-determining protein MrdB. [Ξscherichia coli] gb]AAG54368.1 ] E005242_12 (AE005242) rod shape- determining membrane protein; sensitivity to radiation and drugs [Escherichia coli 0157 :H7] SEQ ID n~2175

Contig9 from gb | AAG54967. l | AE005242_ll (AE005242 ) a minor

SEQ ID n° 7576 PL-2950.2 2006288 to 64% lipoprotein [Escherichia coli 0157 :H7]

2007286 SEQ ID n~2174

TABLEAU II

Contig9 from gb] AAB40832. l) (U82598) penicillin-binding

SΞQ ID n° 7577 PL-2949.2 2007491 to 82% protein 5 [Escherichia coli]

2008660 SEQ ID n~2172 sp|P30977|YBED_ΞCOLI HYPOTHΞTICAL 9.8 KDA

PROTEIN IN LIPB-DACA INTERGENIC REGION (ORF1) pir] (E64797 ybeD protein - Escherichia coli

^"gb|AAA66341.l| (L07636) ORF 1 [Escherichia ^"coli] gb|AAB40831.l| (U82598) hypothetical protein

Contig9 from

[Escherichia coli] gb| AAC73732.l[ (AE000168) SEQ ID n° 7578 PL-6780.1 2008801 to 72? orf, hypothetical protein [Escherichia coli K12]

2009064 dbj |BAA35274.l| (D90703) Hypothetical 9.8 kd protein in lipB-dacA intergenic région

(orfl) . [Bscherichia coli] gb]AAG54965.l(AΞ005242_9 (AΞ005242) orf, hypothetical protein [Ξscherichia coli 0157 :H7] #N/A

Contig9 from sp|P30976 |LIPB_ECOLI LIPOATE-PROTΞIN LIGASE B

SEQ ID n° 7579 PL-2948.1 2009172 to 68% (LIPOATE BIOSYNTHESIS PROTEIN B)

2009837 SEQ ID n~2171 sp|P25845|LIPA_ECOLI LIP0IC ACID SYNTHΞTASΞ (LIP

SYN) (LIPOATE SYNTHASE) pir | |B64797 lipoic acid synthase (EC 2.8.1.-) [validated] - Escherichia

Contig9 from coli dbj |BAA35271.l| (D90703) Lipoic acid SEQ ID n° 7580 PL-2947.1 2009S48 to 87? synthetase (lip-syn) . [Escherichia coli]

2010S13 gb|AAB40828.l| (U82598) lipoic acid synthetase

[Escherichia coli] gb|AAC73729.l| (AE000167) lipoate synthesis, sulfur insertion?

[Escherichia coli K12] SEQ ID n~2170 sp|P37002|CRCB_ECOLI CRCB PROTEIN pir| |F64796 crcB protein - Ξscherichia coli gb| AAB40824.1 |

(U825S8) hypothetical protein [Ξscherichia coli]

Contig9 from gb|AAC73725.l| (AΞ000167) orf, hypothetical SEQ ID n° 7581 PL-3881.1 2011053 to 60? protein [Ξscherichia coli K12] dbj |BAA35267. l|

2011427

(D90703) Hypothetical 13.8 kd protein in cspE- lipA intergenic région. [Escherichia coli] SEQ ID n~3051

TABLEAU II

Contig9 from gb|AAB40823 ,l| (U82598) cold shock-like protein SEQ ID n° 7582 PL-6778.1 2011504 to m 65? [Escherichia coli]

2011716 #N/A pir||F82390 methylated-DNA--protein-cysteine S- methyltransferase (EC 2.1.1.63)

Contig9 from

VCA1017 [similarity] - Vibrio cholerae (group 01 SEQ ID n° 7583 PL-3880.1 —201-1932 to m 60?

Strain N16961) gb|AAF96913.l|

2012393

(AΞ004427) methylated-DNA—protein-cysteine S- methyltransferase [Vibrio cholerae] SEQ ID n~3050 pir| |F70648 probable NrdH protein -

Contig9 from

Mycobacterium tuberculosis (strain H37RV) SEQ ID n° 7584 PL-6777.1 2012725 to 51? emb |CAB06243. l| (Z83866) nrdH [Mycobacterium

2012955 tuberculosis] #N/A

Contig9 from dbj |BAA16538.l| (D90891) similar to [SwissProt SEQ ID n° 7585 PL-6776.1 2012963 to 68? Accession Number P47472] [Escherichia

2013385 coli] #N/A Contig9 from gb|AAA64444.l| (L34407) ribonucleotide reductase SEQ ID n° 7586 PL-2946.1 2013388 to 35? RI subunit [Mycobacterium

2015517 tuberculosis] SEQ ID n~2169 sp | P17424 | RIR4_SALTY RIBONUCLEOSIDE-DIPHOSPHATΞ RΞDUCTASΞ 2 BΞTA CHAIN (RIBONUCLΞOTIDΞ REDUCTASE 2) (R2P PROTEIN) pir| |S34272 ribonucleoside-diphosphate reductase (EC 1.17.4.1) - Salmonella typhimurium pdb|2R2F|A Chain A, Ribonucleotide Reductase R2f Protein From Salmonella Typhimurium

Contig9 from (Oxidized) pdb|2R2F|B Chain B, Ribonucleotide SEQ ID n° 7587 PL-2945.1 2015538 to 84? Reductase R2f Protein From Salmonella

2016497 Typhimurium (Oxidized) pdb|lR2F|A Chain A, Ribonucleotide Reductase R2f Protein From Salmonella Typhimurium pdb|lR2F|B

Chain B, Ribonucleotide Reductase R2f Protein From Salmonella Typhimurium emb|CAA51695. l| (X73226) ribonucleoside- diphosphate reductase [Salmonella typhimurium] SΞQ ID n~2168

TABLEAU II

sp | P14175 | PROV_ECOLI GLYCINE BETAINΞ/L-PROLINE

TRANSPORT ATP-BINDING PROTEIN PROV pir| |BVΞCPV glycine betaine/L-proline transport ATP-binding protein proV - Ξscherichia coli

Contig9 from gb|AAA24427.l| (M24856) proV peptide SEQ ID n° 7588 PL-2944.1 2017095 to 84% [Ξscherichia coli] gb| AAC75724.l| (AE000352)

2018294 ATP-binding component of transport? system for glycine, betaine and proline

[Ξscherichia coli K12] dbj ]BAA1654 . l| (D90891)

GLYCINΞ BETAINE/L-PROLINE TRANSPORT ATP-BINDING

PROTEIN P OV^" [Escherichia coli] SΞQ ID n~2167 sp|P14176|PROW_ECOLI GLYCINE BETAINE/L-PROLINE

TRANSPORT SYSTEM PERMEASE PROTEIN PROW pir| |MMECPW glycine betaine/L-proline transport system permease protein P -

Contig9 from Escherichia coli gb| AAA24428.l| (M24856) proW

SEQ ID n° 7589 PL-2< 13.1 2018287 to 82% peptide [Escherichia coli] gb| AAC75725.1 | 2019372 (AE000352) high-affinity transport system for glycine betaine and proline

[Escherichia coli K12] dbj |BAA16543.1 | (D90891) glycine betaine/proline transport system protein proW [Escherichia coli] SEQ ID n~2166 sp]P14177|PROX_ΞCOLI GLYCINΞ BETAINE-BINDING

PERIPLASMIC PROTΞIN PRΞCURSOR pir| |BLΞCGP glycine betaine/proline transport system binding protein proX precursor - Ξscherichia

Contig9 from coli gb|AAA24429.l| (M24856) proX peptide SEQ ID n° 7590 PL-2942.1 2019442 to 77? precursor [Escherichia coli] gb|AAC75726.l|

2020440 (AE000352) high-affinity transport system for glycine betaine and proline

[Escherichia coli K12] dbj |BAA16544.l| (D90891)

GLYCINE BETAINE-BINDING PERIPLASMIC PROTEIN

PRECURSOR. [Escherichia coli] SEQ ID n~2165

Contig9 from gb|AAG57790.l|AE005497_l (AE005497) putative

SEQ ID n° 7591 PL-2941.1 2020816 to 73% transport protein [Escherichia coli 0157 :H7]

2022006 SEQ ID n~2164

TABLEAU II

sp|P76630|YGAZ_ECOLI HYPOTHETICAL 26.1 KD PROTEIN IN PROX-MPRA INTERGENIC REGION

Contig9 from

_pir| |C65048 hypothetical protein b2682 - SEQ ID n° 7592- PL-2940.1 2022132 to 72?

Escherichia coli (strain K-12) gb| AAC75729. l|

2022890 (AΞ000353) orf, hypothetical protein [Ξscherichia coli K12] SEQ ID n~2163 sp|P43667|YGAH_ΞCOLI HYPOTHETICAL 12.0 KDA

PROTEIN IN PROX-EMRR INTERGENIC REGION pir| |D65048 hypothetical protein (emrR 5'

Contig9 from r gion) - Escherichia coli (strain K-

SΞQ ID n° 7593 PL-6772.1 2022887 to 63?

12) gb|AAC75730.l| (AE000353) orf, hypothetical

2023225 protein [Escherichia coli K12] dbj |BAA16545.l|

(D90891) similar to [SwissProt Accession Number

P43667] [Escherichia coli] #N/A sp|P2420l|MPRA_ECOLI TRANSCRIPTIONAL REPRESSOR

MPRA (EMRR PROTΞIN) pir||S14473 regulatory protein mprA - Ξscherichia coli emb |CAA38090.1 |

ContigS from

(X54151) mprA [Escherichia coli] gb j AAC75731.1 j SEQ ID n° 7594 PL-3879.1 2023355 to p 79?

(AΞ000353) regulator of plasmid mcrB operon

2023882

(miσrocin B17 synthesis) [Escherichia coli K12] dbj |BAA16546.l| (D90891) EMRR

PROTEIN. [Ξscherichia coli] SEQ ID n~3048

Contig9 from gb|AAG57794.l|AE005497_5 (AE005497) multidrug SEQ ID n° 7595 PL-2939.1 2024116 to p 75% résistance secretion protein [Escherichia coli

2025300 0157 :H7] SEQ ID n~2161 sp|P27304|EMRB_ECOLI MULTIDRUG RΞSISTANCΞ

PROTΞIN B pir| |G65048 multidrug résistance protein B - Escherichia coli gb| AAC75733.l]

Contig9 from (AΞ000353) multidrug résistance; probably SEQ ID n° 7596 PL-2938.1 2025315 to p 87? membrane translocase [Escherichia

2026856 coli K12] dbj |BAA16548.l| (D90891) multidrug résistant protein emrB [Escherichia coli] dbj |BAA16553.l| (D90892) multidrug résistant protein emrB [Escherichia coli] SEQ ID n~2160

TABLΞAU II

sp|P33 35|YFIF_EC0LI HYPOTHETICAL TRNA/RRNA

METHYLTRANSFERASE YFIF pir| |D65036 hypothetical

Contig9 from

37.8 kD protein in ung 3' région - Escherichia SEQ ID n° 7597 PL-2937.1 2026906 to -m 73? coli ^" (strain^" K-12) gb|AAC7563 .l|

2027922

(AE000344) orf, hypothetical protein

[Escherichia coli K12] SEQ ID n~2159

Contig9 froitT SEQ ID n° 7598 PL-6766.1 2028022 to No Hits found

2028264 #N/A

Sp|P76594|YFIQ_ECOLI HYPOTHETICAL 98.0 KD

PROTEIN IN^" UNG-PSSA INTERGENIC REGION

Contig9 from pir| ]G65036 hypothetical protein b2584 - SEQ ID n° 7599 PL-2936.1 2028245 to p 82?

Escherichia coli (strain κ-12) gb|AAC75637.l|

2030887

(AΞ000344) orf, hypothetical protein

[Escherichia coli K12] SEQ ID n~2158 dbj |BAA16470.l| (D90886) CDP-DIACYLGLYCEROL--

SΞRINΞ O-PHOSPHATIDYLTRANSFΞRASE (EC

2.7.8.8) (PHOΞPHATIDYLSΞRINΞ SYNTHASΞ) .

Contig9 from

[Ξscherichia coli] dbj |BAA16473.1 | SEQ ID n° 7600 PL-2935.1 2031048 to 81?

(D90887) CDP-DIACYLGLYCΞROL--SΞRINΞ O-

2032406

PHOSPHATIDYLTRANSFERASΞ (ΞC 2.7.8.8

(PHOSPHATIDYLSΞRINΞ SYNTHASE) . [Escherichia coli] SEQ ID n~2157

Contig9 from SEQ ID n° 7601 PL-7426.1 2033324 to m No Hits found

2033479 #N/A Contig9 from SEQ ID n° 7602 PL-7424.1 2034879 to p No Hits found

2034911 #N/A Contig9 from gb|AAG57705.l]AE005489_4 (AΞ005489) heat shock SEQ ID n° 7603 PL-1786.1 2038549 to 91? protein [Ξscherichia coli 0157 :H7]

2041122 SEQ ID n~905

TABLEAU II

sp|P33644|YFIH_EC0LI HYPOTHETICAL 26.3 KDA

PROTΞIN IN SFHB-CLPB INTERGENIC REGION pir| |D65037 hypothetical 26.3 kD protein in clpB Contig9 from

5 'région - Escherichia coli (strain K

SEQ ID n° 7604 PL-1785.1 2041256 to 72?

12) gb|AAC75642.l| (AE000346) orf, hypothetical

2041987 protein [Escherichia coli K12] dbj |BAA16477.1 |

(D90887) similar to [SwissProt Acces^"siόnTNumber

P33644] [Ξscherichia coli] SEQ ID n~904

Conti 9 from gb|AAF78056.l|AF263561_l (AF263561) 23S rRNA SEQ ID n° 7605 PL-1784.1 2041988 to 88? pseudouridine synthase [secondary endosymbiont

2042965 of Glycaspis brimblecombei] SΞQ ID n~903 sp|P77146|YFIO_ECOLI HYPOTHΞTICAL 27.8 KDA

LIPOPROTEIN IN RLUD-PHΞL INTERGENIC REGION

PRΞCURSOR pir||F65037 hypothetical protein b2595 - Ξscherichia coli (strain K-12)

Contig9 from gb|AAC75644.l| (AE000346) orf, hypothetical

SΞQ ID n° 7606 PL-1783.1 2043101 to 76? protein [Ξscherichia coli K12] dbj |BAA1648û .1 |

2043835

(D90887) similar to [SwissProt Accession Number

P44553] [Ξscherichia coli] gb|AAG57708.l|AΞ005490_3 (AE005490) orf, hypothetical protein [Ξscherichia coli 0157 :H7] SEQ ID n~902 sp|P11285|YFIA_ΞCOLI PROTΞIN YFIA pir||Q5ΞCPA hypothetical 13K protein (pheA 5 ' région) -

Escherichia coli gb|AAA24328.l| (M10431) 12,785

MW protein (URF1) [Escherichia coli] emb|CAA94436.l| (Z70523) URF1 (0RFS54)

[Escherichia coli] gb |AAC75646.l| (AE000346)

Contig9 from putative yhbH sigma 54 modulator [Escherichia SΞQ ID n° 7607 PL-6740.1 2044123 to 68? coli K12] db |BAA16 81.1 | (D90887) similar to

2044485

[PIR Accession Number A30275] [Escherichia coli] dbj ]BAA16483.l| (D90888) similar to [PIR

Accession Number A30275] [Escherichia coli] gb|AAG57709.l|AE005490_4 (AE005490) putative yhbH sigma 54 modulator [Escherichia coli 0157.-H7] #N/A

TABLEAU II

sp | O702 | PHΞA_ΞCOLI P-PROTΞIN [INCLUDΞS :

CHORISMATΞ MUTASΞ (CM) ; PRΞPHΞNATE DEHYDRATASE

(PDT)] pir||KMECPW chorismate mutase (EC

5.4.99.5) / prephenate dehydratase (EC

4.2.1.51) pheA [validated] - Escherichia coli

Contig9 from gb]AAA24330.l| (M10431) chorismate

SEQ ID n° 7608 PL-1782.1 2044755 to 78? utase/prephenate dehydratase [Ξscherichia 2045912 coli] gb|AAC75648.l| (AE000346) chorismate mutase-P and prephenate dehydratase

[Ξscherichia coli K12] dbj |BAA16484.l| (D90888) chorismate mutase (EC 5.4.99.5) P / prephenate dehydratase (EC 4.2.1.51)

[Escherichia coli] SEQ ID n~901 pir] |E82237 DNA-binding protein H-NS VC1130

Contig9 from

[imported] - vibrio cholerae (group SEQ ID n° 7609 PL-3878.1 2046381 to 45%

01 Strain N16961) gb | AAF94289.1 | (AΞ004193) DNA

2046827 binding protein H-NS [Vibrio cholerae] SEQ ID n~3047 sp|Q02287|TYRA_ERWHΞ T-PROTEIN [INCLUDΞS:

CHORISMATΞ MUTASΞ (CM) ; PREPHΞNATΞ

Contig9 from DΞHYDROGENASΞ (PDH) ] pir||S29934 chorismate SEQ ID n° 7610 PL-1781.1 2048728 to m 81? mutase (EC 5.4.99.5) T / prephenate

2049849 dehydrogenase (EC 1.3.1.12) - Erwinia herbicola emb|CAA42950.l| (X60420) chorismate mutase [Erwinia herbicola] SEQ ID n~900 gb|AAG57712.l|AE005490_7 (AE005490) 3-deoxy-D-

Contig9 from arabinoheptulosonate-7-phosphate synthase SEQ ID n° 7611 PL-1780.2 2049855 to m 84? (DAHP synthetase, tyrosine repressible)

2050949 [Escherichia coli 0157 :H7] SEQ ID n~899 pir| |A82313 probable beta-ketoadipate enol- lactone hydrolase VC0522 [imported]

Contig9 from

Vibrio cholerae (group 01 strain N16961) SEQ ID n° 7612 PL-1779.1 2051490 to m 62? gb] AAF93690.l| (AΞ004138) beta-ketoadipate enol-

2052296 lactone hydrolase, putative [Vibrio cholerae] SEQ ID n~897

TABLEAU II

sp|P02420 |RL19_EC0LI 50S RIBOSOMAL PROTΞIN L19 pir| |R5ΞC19 ribosomal protein L19 [validated] -

Ξscherichia coli emb|CAA25960.l| (X01818) ribosomal protein L19 (rplS gène) (aa 1-115)

Contig9 from [Ξscherichia coli] gb| AAC75655.1 | SEQ ID n» 7613 PL-6738.1 2052800 to m 93? (AE000346) 50S ribosomal subunit protein L19

2053153 [Ξscherichia coli K12] dbj |BAA16491. l| (D90888) ribosomal protein L19 [Escherichia coli] gb[AAG57717.l|AE005490_12 (AE005490) 50S ribosomal subunit protein L19 [Escherichia coli

0157.-H7] #N/A sp | P36244 | RMD SΞRMA TRNA (GUANINE-NI) -

Contig9 from METHYLTRANSFERASE (MIG-METHYLTRANSFERASΞ) (TRNA

SEQ ID n° 7614 PL-1778.1 2053218 to m 92? [GM37] METHYLTRANSFΞRASΞ) gb | AA50783.1 |

2053970 (L23334) mlG-methyltransferase [Serratia marcescens] SΞQ ID n~896 pir||C65039 hypothetical 21K protein (trmD-rpsP intergenic région) - Ξscherichia coli gb|AAC75657.l| (AΞ000346) orf, hypothetical

Contig9 from protein [Ξscherichia coli K12] dbj |BAA16493.1 | SEQ ID n° 7615 PL-3877.1 2054010 to

(D90888) similar to [SwissProt Accession Number

2054567

P21504] [Escherichia coli] gb|AAG57719.l|AE005490_14 (AE005490) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~3046 sp]P44382[RS16_HAEIN 30S RIBOSOMAL PROTEIN S16

Contig9 from pir||D64054 ribosomal protein S16 - Haemophilus SΞQ ID n° 7616 PL-6737.1 2054577 to m 78? influenzae (strain Rd KW20) gb|AAC21873.l|

2054825 (U32705) ribosomal protein S16 (rpSie)

[Haemophilus influenzae Rd] #N/A

TABL AU II

sp]P07019]SR54_ECOLI SIGNAL RECOGNITION PARTICLE PROTEIN (FIFTY-FOUR HOMOLOG) (P48) pir||E65039

__ signal récognition particle protein -

Contig9 from Escherichia coli gb|AAC75659. l| (AE000347) GTP- SEQ ID n° 7617 PL-1777.2 2054962 to m 92? binding export factor binds to signal séquence,

2056323 GTP and RNA [Escherichia coli K12] gb]AAG57721.l|AE005491_l (AΞ005491) GTP-binding export factor binds to signal séquence, GTP and RNA [Ξscherichia coli 0157 :H7] #N/A

Contig9 from gb|AAD31437.l|AF130857_l (AF130857)-CorE

SEQ ID n° 7618 PL-1776.1 2056508 to 80? [Salmonella typhimurium]

2057299 SEQ ID n~894

Contig9 from sp | P37908 | FJD_ECOLI HYPOTHΞTICAL 46.4 KDA

SEQ ID n° 7619 PL-1775.1 2057339 to 86? PROTΞIN IN FFH-GRPΞ INTΞRGΞNIC REGION

2058631 SEQ ID n~893

Contig9 from gb|AAF73475.l|AF268390_2 (AF268390) LuxS

SEQ ID n° 7620 PL-3875.1 2058730 to 86% [Salmonella typhimurium]

2059245 SEQ ID n~3045 sp|068838|GSHl_SALTY GLUTAMATE--CYSTΞINΞ LIGASE

Contig9 from (GAMMA-GLUTAMYLCYSTEINE SYNTHETASE) SEQ ID n° 7621 PL-1774.1 2059398 to m 76? (GAMMA-ΞCS) (GCS) gb|AAC09345.1 | (AF055352)

2060957 gamma-glutamylcysteine synthetase [Salmonella typhimurium] SEQ ID n~892

Contig9 from emb[CAB46440.l| (AJ238885) RsmA protein [Erwinia SEQ ID n° 7622 PL-6732.1 2062170 to 89? carotovora]

2062355 #N/A splP00957|SYA_ECOLI ALANYL-TRNA SYNTHΞTASΞ

(ALANINE- -TRNA LIGASΞ) (ALARS) pir | ( SYECAT alanine- -tRNA ligase (EC 6.1.1.7) [validated] -

Contig9 from

Escherichia coli gb |AAC75739.1 | (AE000353) SEQ ID n° 7623 PL-1773.1 2062602 to m 87% alanyl-tRNA synthetase [Ξscherichia coli K12]

2065232 dbj |BAAlS559.l| (D90892) ALANYL-TRNA SYNTHETASE

(EC 6.1.1.7) (ALANINE--TRNA LIGASE)

(ALARS) . [Ξscherichia coli] SEQ ID n~891

TABLΞAU II

Contig9 from sp|P96185|RΞCA_XΞNBV RΞCA PROTEIN (RECOMBINASE SΞQ ID n° 7624 PL-1772.1 2065623 to 94? A) gb|AAD12585.l| (U87924) RecA [Xenorhabdus

2066690 bovienii] SEQ ID n~890 sp|P51967|YGAD_ENTAG HYPOTHETICAL 17.2 KD

Contig9 from PROTEIN 1 IN RECA 5 ' EGION pir| |S31480

SEQ ID n° 7625 PL-1771.1 2066813 to m 63? hypothetical protein 1 - Enterobacter

2067355 agglomerans gb] AA91765.l| (L03291) unnamed protein [Pantoea agglomerans] SEQ ID n~889 sp|P39196|YGED_ECOLI HYPOTHETICAL 41.7 KD

PROTEIN IN MUTH-AAS INTERGENIC REGION pir| |D65066 hypothetical protein in mutH-aas

Contig9 from intergenic région - Escherichia coli SΞQ ID n° 7626 PL-1770.1 2067381 to m 78%

(Strain K-12) gb|AAB4048 .l| (U29581) ORF__f397

2068577

[Escherichia coli] gb( AAC75874.1 | (AE000367) putative résistance proteins [Ξscherichia coli

K12] SEQ ID n~888 sp | P31119 | AAS_ΞCOLI AAS BIFUNCTIONAL PROTEIN

[INCLUDES : 2 -

ACYLGLYCΞROPHOSPHOETHANOLAMINΞ ACYLTRANSFERASΞ

(2-ACYL-GPE ACYLTRANSFERASE) ; ACYL-ACYL CARRIER

PROTEIN SYNTHETASΞ (ACYL-ACP

SYNTHΞTASΞ)] pir||E65066 2- acylglycerophosphoethanola ine acyl

Contig9 from transferase/acyl carrier protein SΞQ ID n° 7627 PL-1769.1 2068590 to m 74' synthetase - Escherichia coli (strain K-12)

2070509 gb|AAB40483.l| (U29581) 2- acylglycerophosphoethanolamine acyl transferase/acyl carrier protein synthetase [Escherichia coli] gb | AAC75875.1 |

(AΞ000367) 2-acyl-glycerophospho-ethanolamine acyltransferase; acyl-acyl-carrier protein synthetase [Escherichia coli

K12] SEQ ID n~886

TABLEAU II

splP10880|AROL_ERWCH SHIKIMATE KINASE (SK) pir||S096l3 shikimate kinase (EC 2.7.1.71) -

Erwinia chrysanthemi pdb | 1SH | A Chain A, The

Contig9 from Three-Di ensional Structure Of Shikimate Kinase SEQ ID n° 7628 PL-3872.1 2070609 to 61% From Erwinia Chrysanthemi pdb|2SHK|A

2071133 Chain A, The Three-Dimensional Structure Of

Shikimate Kinase From Erwinia

Chrysanthemi Complexed With Adp emb|CAA32883.l|

(X14777) shikimate kinase [Erwinia chrysanthemi] SEQ ID n~3044 sp|P17857|PROA_SERMA GAMMA-GLUTAMYL PHOSPHATE

REDUCTASE (GPR) (GLUTAMATE-5-SEMIALDΞHYDE

DEHYDROGENASE) (GLUTAMY -GAMMA-SEMIALDEHYDE

DEHYDROGENASE) pir| | RDSEΞM glutamate-5-

Contig9 from semialdehyde dehydrogenase (ΞC 1.2.1.41) - SEQ ID n° 7629 PL-1768.1 2071434 to m 87%

Serratia marcescens emb [CAA37255.1 |

2072687

(X53086) gamma-glutamyl phosphate reductase [Serratia marcescens] dbj |BAA14365. l| (D90351) gamma-glutamyl phosphate reductase [Serratia marcescens] SΞQ ID n~885 sp|P17856| ROB_SΞRMA GLUTAMATE 5 -KINASE (GAMMA-

Contig9 from GLUTAMYL KINASΞ) (GK) pir||κiSΞΞM glutamate 5- SEQ ID n° 7630 PL-1767.1 2072697 to m 89? kinase (ΞC 2.7.2.11) - Serratia marcescens

2073803 emb |CAA3725 . l| (X53086) gamma-glutamyl kinase

[Serratia marcescens] SEQ ID n~884

Contig9 from gb|AAG54564.l|AE005202_2 (AE005202) orf,

SEQ ID n° 7631 PL-1766.2 2074001 to m 72? hypothetical protein [Ξscherichia coli 0157 :H7]

2075248 SEQ ID n~883

Contig9 from

SEQ ID n° 7632 PL-3871.1 2075263 to m 39? prf | |ll02210A protein gpt [Ξscherichia coli]

2075724 SEQ ID n~3043

Contig9 from gb|AAG54562.l|AΞ005201_15 (AE005201) aminoacyl-

SEQ ID n° 7633 PL-1765.2 2075949 to 82? histidine dipeptidase (peptidase D)

2077409 [Escherichia coli 0157 :H7] SEQ ID n~882

TABLBAU II

sp | Q47155 | DINP_ECOLI DNA-DAMAGE-INDUCIBLE

PROTEIN P pir] ]H64747 DNA-damage-inducibile protein dinP - Ξscherichia coli dbj |BAA07593.1 |

ContigS from (D38582) DinP [Ξscherichia coli] gb]AAB08651.1 j SEQ ID n° 7634 PL-1764.1 2077445 to m 83% (U70214) DinP [Ξsσherichia coli] gb|AAC73335. lj

2078500 (AE000131) damage-inducible protein P; putative tRNA synthetase [Escherichia coli

K12] dbj (BAA77901.1| (D83535) DNA-damage- inducible protein p. [Escherichia coli] SΞQ ID n~881 sp|P44523 |HXC1_HAEIN HΞMΞ-HΞMOPEXIN UTILIZATION

Contig9 from PROTEIN C PRΞCURSOR pir| |B64049 outer membrane SΞQ ID n° 7635 PL-1763.1 2078761 to 61? protein hxuC homolog - Haemophilus influenzae

2081061 (strain Rd KW20) gb|AAC21789. l| (U32696) hemin receptor (hemR) [Haemophilus influenzae Rd] SEQ ID n~880

Contig9 from SΞQ ID n^» 7636 PL-6729.1 2081434 to No Hits found

2081631 #N/A Contig9 from ref [NP_0532l8.l| pX02-63 [Bacillus anthracis] SΞQ ID n° 7637 PL-1762.1 2081636 to 50? gb|AAF13668.l|AF188935_66 (AF188935) pX02-63

2082271 [Bacillus anthracis] SΞQ ID n~879 pir| |F83158 probable sigma-70 factor, ΞCF subfamily PA3899 [imported] -

ContigS from

Pseudomonas aeruginosa (strain PAOl) SΞQ ID n° 7638 PL-3870.1 2082840 to 53% gb|AAG07286.l|AE004807_5 (AE004807) probable

2083340 sigma-70 factor, ΞCF subfamily [Pseudomonas aeruginosa] SΞQ ID n~3042 pir| |F83047 conserved hypothetical protein

ContigS from PA4792 [imported] - Pseudomonas SΞQ ID n° 7639 PL-1761.1 2083422 to 55% aeruginosa (strain PAOl)

2084318 gb|AAG08178.1 |AE004892_9 (AE004892) conserved hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~87É

ContigS from dbj |BAA16380.1 | (D90878) FORMATE HYDROGENLYASΞ SEQ ID n° 7640 PL-1760.1 2084485 to m 37% TRANSCRIPTIONAL ACTIVATOR.

2086416 [Escherichia coli] SEQ ID n~877

TABLEAU II

pir|]S77026 hypothetical protein S110783 -

Contig9 from

Synechocystis sp. (strain PCC 6803) SEQ ID n° 7641 PL-3869.1 2086694 to 71? dbj |BAA10718.1| (D64005)_^hypothetical protein

2087176^"

[Synechocystis sp . ] SEQ ID n~3040 pir||S77025 nitrilase (EC 3.5.5.1) -

Contig9 from

Synechocystis sp. (strain PCC 6803) SEQ ID n° 7642 PL-1759.1 2087206 "to 65% dbj |BAA107l7.ι| (D64005) nitrilase

2088213

[Synechocystis sp . ] SEQ ID n~875 pir]|S77024 hypothetical protein S110785 -

Contig9 from

Synechocystis sp. (strain PCC 6803) SEQ ID n° 7643 PL-1758.1 2088237 to 67? dbj |BAA10716.I ] ^'(D6ÏÔ05) hypothetical protein

2089334

[Synechocystis sp . ] SEQ ID n~874 pir||S77023 hypothetical protein sll0786 -

Contig9 from

Synechocystis sp. (strain PCC 6803) SEQ ID n° 7644 PL-3868.1 2089347 to 41% dbj |BAA10715.l| (D64005) hypothetical protein

2089910

[Synechocystis sp . ] SEQ ID n~303S sp|Q55946[ 787_SYNY3 HYPOTHΞTICAL 3 .7 KD

Contig9 from PROTEIN SLL0787 pir||S77022 hypothetical SΞQ ID n° 7645 PL-1757.1 2089910 to p 41% protein sll0787 - Synechocystis sp. (strain PCC

2090962 6803) dbj |BAA10714.1| (D64005) hypothetical protein [Synechocystis sp . ] SEQ ID n~873 pir||S7702l hypothetical protein ssll464 -

Contig9 from

Synechocystis sp. (strain PCC 6803) SEQ ID n° 7646 PL-6725.1 2090950 to 50? dbj ]BAA10713.l| (D64005) hypothetical protein

2091240

[Synechocystis s . ] #N/A pir||S77027 hypothetical protein slrOSOl -

Contig9 from

Synechocystis sp. (strain PCC 6803) SEQ ID n° 7647 PL-1756.1 2091253 to 61? dbj |BAA10719.1 | (D64005) hypothetical protein

2092590

[Synechocystis sp . ] SEQ ID n~872 ref |NP_044235.1] TnpA [Enterobacter aerogenes]

Contig9 from pir||T08494 probable transposase - Enterobacter SEQ ID n° 7648 PL-1755.1 2092858 to m 84% aerogenes plasmid R751 gb| AAB03489. l| (U60777)

2093862 transposase [Plasmid R751] gb ] AC64438.l|

(U67194) TnpA [Enterobacter aerogenes] SEQ ID n~871

TABLEAU II

ref JNP_061690.lj conserved hypothetical protein

[Xylella fastidiosa] pir| |B82865 conserved

Contig9 from hypothetical protein XFa0034 [imported] - SEQ ID n° 7649 PL-3867.1 2094147 to 61%

Xylella fastidiosa (strain 9a5c)

2094527 gb|AAF85603.l|AE003851_34 (AE003851) conserved hypothetical protein [Xylella fastidiosa] SΞQ ID n~3038

^'ref |NP_061691.l| hypothetical protein [Xylella fastidiosa] pir[ |C82865 hypothetical protein

ContigS from

XFa0035 [imported] - Xylella fastidiosa SEQ ID n° 7650 PL-6724.1 20S455S to 26%

(strain 9a5c) gb|AAF8560 . l|AE003851_35 _ 20S4846

(AΞ003851) hypothetical protein [Xylella fastidiosa] #N/A ref ]NP_044235.l| TnpA [Ξnterobacter aerogenes]

Contig9 from pir||T08494 probable transposase - Enterobacter SEQ ID n° 7651 PL-1754.1 2095175 to m 84? aerogenes plasmid R751 gb|AAB03489. l| (U60777)

2096179 transposase [Plasmid R751] gb| AAC64438.l|

(U67194) TnpA [Enterobacter aerogenes] SΞQ ID n~870

Contig9 from SEQ ID n° 7652 PL-7200.1 2096227 to m No Hits found

2096379 #N/A pir] |H82412 diaminobutyrate--pyruvate aminotransferase VCA0824 [imported] -

Contig9 from

Vibrio cholerae (group 01 strain N16961) SEQ ID n° 7653 PL-6722.1 2096486 to 68? gb|AAF96722.l| (AE004410) diaminobutyrate--

2096836 pyruvate aminotransferase [ ibrio cholerae] /A pir[ [T17468 peptide-synthetase - Amycolatopsis

Contig9 from mediterranei (fragment) emb|CAA66454.l| SEQ ID n° 7654 PL-1753.1 2097009 to m 47%

(X97860) peptide-synthetase [Amycolatopsis

2100191 mediterranei] SΞQ ID n~869

Contig9 from gb|AAG34185.l(AF321122_4 (AF321122) Sim-nl SEQ ID n° 7655 PL-1752.1 2100201 to m 60? [Streptomyces antibioticus]

2101436 SΞQ ID n~868

TABLEAU II

sp|P3964l|YWFΞ_BACSU HYPOTHETICAL 52.3 KD

PROTEIN IN ROCC-PTA INTERGΞNIC RΞGION

Contig9 from pir|[S39738 ywfΞ protein - Bacillus subtilis SEQ ID n° 7656 PL-1751.1 -2101433 to m 26% emb|CAA5l639.l| (X73124) ipa-83d [Bacillus

2102956 subtilis] emb|CAB15798.l| (Z99123) alternate gène name : ipa-83d [Bacillus subtilis] SEQ ID n~867 pir[ |τi7413πhîoesterase II (ΞC 3.1.2.-) -

Contig9 from

Streptomyces venezuelae gb| AAC69333.1 | SEQ ID n° 7657 PL-1750.1 2102956 to m 46%

(AF079138) thioesterase II PikAV [Streptomyces

2103720 venezuelae] SEQ ID n~866

Contig9 from emb|CAB93682.1] (Y17268) hypothetical protein SEQ ID n° 7658 PL-6721.1 2103717 to m 43% [Streptomyces viridochromogenes]

2103896 #N/A pir| |S74461 ABC transporter slrl494 -

Contig9 from

Synechocystis sp. (strain PCC 6803) SEQ ID n° 7659 PL-1749.1 2103893 to m 50% dbj |BAA16613.l| (D90899) ABC transporter

2105539

[Synechocystis sp.] SEQ ID n~864 pir| |S74455 ABC-type transport protein slrl488 -

Contig9 from

Synechocystis sp. (strain PCC 6803) SEQ ID n° 7660 PL-1748.1 2105536 to m 48% dbj |BAA16607.l| (D90899) ABC transporter

2107290

[Synechocystis sp . ] SEQ ID n~863 pir| |F83345 probable non-riboso al peptide synthetase PA2402 [imported] -

Contig9 from

Pseudomonas aeruginosa (strain PAOl) SEQ ID n° 7661 PL-1747.1 2107292 to m 42% gb(AAG05790.l|AE004667_l (AE004667) probable non

2112301 ribosomal peptide synthetase [Pseudomonas aeruginosa] SΞQ ID n~862

Contig9 from emb|CAB36627.l| (AL035480) putative polyketide SEQ ID n° 7662 PL-1746.1 2112304 to 26% synthase [Mycobacterium leprae]

2116107 SEQ ID n~861 Contig9 from gb|AAD04758.l| (U95370) lichenysin synthetase B; SEQ ID n° 7663 PL-1745.2 2116104 to m 47% LicB [Bacillus licheniformis]

2117888 SΞQ ID n~860

TABLΞAU II

pir] |A83358 hypothetical protein PA2303

Contig9 from [imported] - Pseudomonas aeruginosa SEQ_ID n° 7664 PL-1744.2 2117867 to 503 (strain PAOl) gb|AAG05691.1 | E004656_3

2118658 (AE004656) hypothetical protem [Pseudomonas aeruginosa] SEQ ID n~859 sp|P77354|YAFU_ECOLI HYPOTHΞTICAL 12.1 KD

PROTΞIN IN DNAQ-GMHA INTΞRGENIC REGION

Contig9 from pir| |C64746 yafu protein - Escherichia coli SEQ ID n° 7665 PL-1743.2 2119915 to 16? gb|AAB08640.l| (U70214) hypothetical protein

2120931

[Escherichia coli] gb|AAC73322.1 | (AE000130) orf, hypothetical protein [Ξscherichia coli K12] SΞQ ID n~858

Contig9 from SEQ ID n° 7666 PL-3865.1 2121360 to No Hits found

2121761 SΞQ ID n~3036 Contig9 from SEQ ID n° 7667 PL-1742.1 2122386 to No Hits found

2123240 SΞQ ID n~857 pir| [H82093 conserved hypothetical protein

Contig9 from VC2288 [imported] - Vibrio cholerae SEQ ID n° 7668 PL-6714.1 2123883 to m 54? (group 01 Strain N16961) gb|AAF95432.l|

2124107 (AΞ004300) conserved hypothetical protein

[Vibrio cholerae] m/A pir] |A82094 thiamin biosynthesis lipoprotein

Contig9 from ApbE VC2289 [imported] - Vibrio SEQ ID n° 7669 PL-1741.1 2124124 to 72? cholerae (group 01 strain N16961)

2125152 gb| AAF95433.l| (AE004300) thiamin biosynthesis lipoprotein ApbE [Vibrio cholerae] SEQ ID n~856 pir| |D64052 Na+-translocating NADH-ubiquinone oxidoreductase (EC 1. - . - . -) beta

Contig9 from chain - Haemophilus influenzae (strain Rd KW20) SEQ ID n° 7670 PL-1740.1 2125232 to 89? gb|AAC21841.l| (U32702) Nqr6 subunit of Na-

2126458 translocating NADH-quinone reductase complex beta-subunit (nqr6) [Haemophilus influenzae Rd] SEQ ID n~855

TABL AU II

sp|Q56589|NQRΞ_VIBAL NA(+) -TRANSLOCATING NADH-

QUINONΞ REDUCTASE SUBUNIT E (NA-NQR

COMPLEX SUBUNIT 5) pir||S65530 sodium- translocating NADH dehydrogenase (ubiquinone)

Contig9 from

(EC 1.6.5.-) nqrE chain - Vibrio SΞQ ID n° 7671 PL-3864.1 2126474 to m 90? alginolyticus dbj ]BAA22914.l| (AB008030) Nqr5

2127070 subunit of Na-translocating NADH-quinone reductase complex [Vibrio alginolyticus] prf | | 2111280C Na-translocating

NADH quinone reductase [Vibrio alginolyticus] SEQ ID n~3035

Contig9 from gb|AAK03415.l| (AE006171) unknown [Pasteurella SΞQ ID n° 7672 PL-1739.1 2127079 to m 90? multocida]

2127708 SEQ ID n~853 pir||S65528 sodium-translocating NADH dehydrogenase (ubiquinone) (ΞC 1.6.5.-) nqrC chain - Vibrio alginolyticus

ContigS from dbj |BAA22912.l] (AB008030) Nqr3 subunit of Na- SΞQ ID n° 7673 PL-1738.1 2127701 to m 67? translocating NADH-quinone reductase

2128498 complex gamma-subunit [Vibrio alginolyticus] prf | |2U1280A Na-translocating NADH quinone reductase [Vibrio alginolyticus] SEQ ID n~852

Contig9 from dbj |BAA22911.1| (AB008030) Nqr2 subunit of Na- SΞQ ID n° 7674 PL-1737.1 2128491 to m 86? translocating NADH-quinone reductase

2129729 complex [Vibrio alginolyticus] SEQ ID n~851 pir| |A81919 probable sodium-translocating NADH dehydrogenase (ubiquinone) (EC

Contig9 from 1.6.5.-) chain A NMA0752 [imported] - Neisseria SΞQ ID n° 7675 PL-1736.1 2129734 to m 77? meningitidis (group A strain Z2491)

2131077 emb|CAB84035.l| (AL162754) putative Na (+) - translocating NADH-ubiquinone reductase subunit A [Neisseria meningitidis Z2491] SΞQ ID n~850

TABLEAU II

sp|Q47148|YAFK_ECOLI HYPOTHETICAL 28.0 KD

PROTEIN IN GMHA-DINJ INTERGΞNIC REGION

PRECURSOR pir| |A64747 _robable membrane protein yafK - Escherichia coli dbj |BAA07586.1 |

(D38582) YafK [Escherichia coli] gb | AAB08646.1 |

Contig9 from (U70214) hypothetical [Ξscherichia coli] SEQ ID n° 7676 PL-1735.1 2131497 tô^~~ p 63% gb|AAC73328.l| ÀÈ000Ï31) orf, hypothetical

2132240 protein [Ξscherichia coli K12] dbj |BAA77894.l|

(D83536) Hypothetical 28.0 kd protein in gmhA- dinJ intergenic région precursor.

[Ξscherichia coli] gb|AAG54549.l(AΞ005201_2

(AE005201) orf, hypothetical protein

[Escherichia coli 0157 :H7] SEQ ID n~849 sp|Q47147|YAFJ_ECOLI HYPOTHΞTICAL 28.6 KD

PROTΞIN IN GMHA-DINJ INTΞRGΞNIC RΞGION pir| |H64746 yafJ protein - Escherichia coli

Contig9 from dbj |BAA07585.l[ (D38582) YafJ [Escherichia coli] SEQ ID n° 7677 PL-1734.1 2132211 to m 83% gb|AAB08645.l| (U70214) hypothetical

2132978 [Ξscherichia coli] gb| AAC73327.1 | (AE000131) putative amidotransferase [Escherichia coli K12] dbj |BAA77893.l| (D83536) Hypothetical protein

HI1037 [Escherichia coli] SΞQ ID n~848

Contig9 from gb|AAB08644.l| (U70214) hypothetical

SEQ ID n° 7678 PL-1733.1 2133128 to 89% [Escherichia coli]

2133709 SEQ ID n~847

Contig9 from dbj |BAA77891.l] (D83536) Acyl-CoA dehydrogenase

SEQ ID n° 7679 PL-1732.1 2133969 to 87? (ΞC 1.3.99.-). [Ξscherichia coli]

2136404 SEQ ID n~846

Contig9 from gb|AAG57950.l|AE005512_9 (AE005512)

SEQ ID n° 7680 PL-1731.1 2136477 to m 74? diaminopimelate decarboxylase [Escherichia coli

2137787 0157 :H7] SEQ ID n~845

Contig9 from gb|AAG57951.l|AE005512_10 (AE005512) positive

SEQ ID n° 7681 PL-1730.1 2137901 to 76% regulator for lys [Ξscherichia coli 0157 :H7]

2138836 SEQ ID n~844

TABLEAU II

pir]|F83638 probable transcription regulator

PA0056 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n°-7-682 PL-1729.1 2138819 to m 70? gb|AAG03446.l|AE004445_7 (AE004445) probable

2139733 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~842 pir||G83638 hypothetical protein^" PA0057

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 7683 PL-1728.1 2139839 to p 57? (strain PAOl) gb|AAG03447. l| AΞ004445_8

2140723 (AEO 04445) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~841 pir| |H83638 hypothetical protein PA0058

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 7684 PL-1727.1 2140755 to p 55? (Strain PAOl) gb| AG03448.1 | AE004445_9

2141396 (AE004445) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~840 sp| 06896 |LEP4_AERSA TYPE 4 PREPILIN-LIKE

PROTEINS LEADER PEPTIDE PROCESSING ENZYMΞ

Contig9 from

[INCLUDΞS.- LEADER PEPTIDASE (PREPILIN SEQ ID n° 7685 PL-1726.1 2141445 to m 49?

PΞPTIDASΞ) ; N-METHYLTRANSFERASE ]

2142056 gb|AAC23569.l| (AF059249) type IV prepilin peptidase TapD [Aeromonas salmonicida] SEQ ID n~839 pir] |A65080 hypothetical protein in endA-gshB intergenic région - Ξscherichia coli

Contig9 from (strain K-12) gb|AAA69113. l| (U28377) ORF_o252 SEQ ID n° 7686 PL-1725.1 2142382 to p 74% [Ξscherichia coli] gb| AC75983.11 (AΞ000377)

2143113 orf, hypothetical protein [Ξscherichia coli K12] gb|AAG58077.l|AE005525_3 (AE005525) orf, hypothetical protein [Escherichia coli 0157 :H7] SΞQ ID n~838

TABLEAU II

sp|P04425 |GSHB_ECOLI GLUTATHIONE SYNTHETASE

(GLUTATHIONE SYNTHASE) (GSH SYNTHETASΞ)

(GSH-S) (GSHASΞ) pir| | SYECGS glutathione synthase (EC 6.3.2.3) - Escherichia coli pdb|lGSA| Structure Of Glutathione Synthetase

Complexed With Adp And Glutathione

Contig9 from pdb|lGSH| Structure Of Escherichia Coli

SEQ ID n° 7687 PL-1724.1 2143123 to 88%

Glutathione Synthetase At Ph 7.5 pdb | 2GLT |

2144073

Structure Of Escherichia Coli Glutathione

Synthetase At Ph 6.0. emb|CAA25826.l| (X01666)

GSH-II [Escherichia coli] gb|AAA69114.l]

(U28377) glutathione synthetase [Escherichia coli] gb|AAC75984.l| (AΞ000377) glutathione synthetase [Ξsσherichia coli K12] SΞQ ID n~837

Contig9 from SEQ ID n° 7688 PL-1723.1 2144183 to p 69% sp|P52049|YQGΞ_ΞCOLI PROTΞIN YQGΞ

2144746 SΞQ ID n~836 ContigS from gb|AAK03954.l| (AΞ006224) unknown [Pasteurella SEQ ID n° 7683 PL-6707.1 2144747 to 81? multocida]

2145166 #N/A Contig9 from gb|AAG58081.l|AΞ005525_7 (AΞ005525) putative SEQ ID n° 7690 PL-1722.1 2145221 to m 69? protein transport [Ξscherichia coli 0157 :H7]

2146258 SΞQ ID n~835 sp|P52054|YGGS_ΞCOLI HYPOTHΞTICAL 25.8 KD

PROTΞIN IN GSHB-ANSB INTERGENIC REGION pir| |F65080 hypothetical protein b2951 -

Contig9 from Escherichia coli (strain K-12) gb[AAA69118.l| SEQ ID n° 7691 PL-1721.1 2146280 to 77? (U28377) 0RF_o234 [Ξscherichia coli]

2146975 gb|AAC75988.l| (AΞ000378) orf, hypothetical protein [Ξscherichia coli K12] gb|AAG58082.l|AE005525_8 (AE005525) orf, hypothetical protein [Escherichia coli 0157 :H7] SΞQ ID n~834

TABLEAU II

pir| |D82321 pyrroline-5-carboxylate reductase

Contig9 from VC0460 [imported] - Vibrio cholerae SEQ ID n° 7692 PL-1720.1 2147001 to 71% (group 01 strain N16961) gb |AAF93633.1 |

2147822 (AE004132) pyrroline-5-carboxylate reductase

[Vibrio cholerae] SEQ ID n~833 pir||C82321 conserved hypothetical protein

Contig9 from VC0459 [imported] ^"- Vibrio^' cholerae SEQ ID n° 7693 PL-3863.1 2147841 to 75? (group 01 strain N16961) gb | AAF93632. l]

2148389 (AE004132) conserved hypothetical protein

[Vibrio cholerae] SEQ ID n~3034

Contig9 from gb|AAG58085.l|AE005525_ll (AE005525) putative SEQ ID n° 7694 PL-3862.1 2148416 to 89? ribosomal protein [Escherichia coli 0157 :H7]

2149009 SEQ ID n~3033 sp|P52062|YGGW_ECOLI HYPOTHΞTICAL 42.6 KDA

PROTΞIN IN GSHB-ANSB INTBRGΞNIC RΞGION

Contig9 from pir| |B65081 hypothetical protein b2955 - SEQ ID n° 7695 PL-1719.1 2149002 to 86% Ξscherichia coli (strain K-12) gb |AAA69122. l]

2150132 (U28377) ORF_o378 [Ξscherichia coli] gb|AAC75992.l| (AE000378) putative oxidase

[Escherichia coli K12] SEQ ID n~831

Contig9 from SEQ ID n° 7696 PL- 1718.1 2150753 to No Hits found

2151415 SEQ ID n~830 pir] |E69763 probable ferrichrome ABC transporter yclQ - Bacillus subtilis dbj [BAA09015.l|

Contig9 from (D50453) ferrie anguibactin-binding protein

SEQ ID n° 7697 PL-1717.1 2152100 to 51? precusor FatB of V. anguillarum

2153050 [Bacillus subtilis] emb|CAB12191.l| (Z99106) similar to ferrichrome ABC transporter (binding protein) [Bacillus subtilis] SΞQ ID n-829

ContigS from gb|AAG58089.l|AE005526_2 (AE005526) orf, SEQ ID n° 7698 PL-1716.1 2153168 to 66? hypothetical protein [Escherichia coli 0157 :H7]

21538S0 SEQ ID n~828

TABLEAU II

sp|P77470|GLS2_ECOLI PROBABLE GLUTAMINASE YNEH pir| |G64906 glutaminase homolog yneH - .. Escherichia coli dbj |BAA15206.11 (D90795) Glutaminase, kidney isoform precursor (ΞC

Contig9 from 3.5.1.2) (GLS). [Escherichia coli]

SEQ ID n° 7699 PL-1715.1 2153938 to m 79? dbj |BAA15214.1 | (D90796) Glutaminase, kidney_.

2154864 isoform precursor (BC 3.5.1.2) (GLS).

[Ξscherichia coli] gb|AAC74597.l| (AΞ000250) putative glutaminase [Escherichia coli K12] gb|AAG56241.l|AE005352_7 (AE005352) putative glutaminase [Escherichia coli 0157 :H7] SEQ ID n~827

Contig9 from gb|AAG58090.l|AE005526_3 (AΞ005526) orf, SEQ ID n° 7700 PL-6704.1 2154944 to m 81? hypothetical protein [Escherichia coli 0157 :H7]

2155270 #N/A sp|P32049|YGGH_ECOLI HYPOTHETICAL 27.3 KD

PROTEIN IN ANSB-MUTY INTERGENIC REGION (F239) pir] ]G65081 hypothetical 27.3 kD protein in mutY

ContigS from

5' région - Ξscherichia coli (strain SΞQ ID n° 7701 PL-1714.1 2155270 to m 82?

K-12) gb|AAA69127.l| (U28377) ORF_f239;

2155989 alternate name yggH; orf of M59471 [Ξscherichia coli] gb|AAC75997.l| (AE000378) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~826 sp|P17802|MUTY_ECOLI A/G-SPΞCIFIC ADENINΞ

GLYCOSYLASE pir| |B38535 A/G-specific adenine glycosylase (EC 3.2.2.-) [validated] -

Ξscherichia coli emb] CAA36624. l| (X52391) adenine glycosylase (AA 1-350) [Ξscherichia

Contig9 from coli] gb|AAA72957.l] (M59471) A/G-specific SΞQ ID n° 7702 PL-1713.1 2156362 to 80? adenine glycosylase [Escherichia coli]

2157399 gb|AAA69128.l| (U28377) CG Site No. 18130; alternate name micA [Escherichia coli] gb|AAC75998.l| (AE000378) adenine glycosylase;

G . C --> T.A transversions

[Ξscherichia coli K12] SΞQ ID n~825

TABLEAU II

sp]P52065|YGGX_ECOLI PROTΞIN YGGX pir||A65082 hypothetical protein b2962 - Ξscherichia coli

Contig9 from (Strain K-12) gb| AAA69129.l| (U28377) ORF_o91 SEQ ID n° 7703 PL-6700.1 2157430 to P 84? [Ξscherichia coli] ^~gb | AAC75999.1 | (AE000378)

2157702 orf, hypothetical protein [Ξscherichia coli K12] gb|AAG58093.l|AE005526_6 (AΞ005526) orf, hypothetical pr teιn^"[Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG58094.l|AΞ005526_7 (AE005526) membrane- SEQ ID n° 7704 PL-1712.2 2157766 to 81? bound lytic murein transglycosylase C

2158839 [Ξscherichia coli 0157 :H7] SΞQ ID n~824 Contig9 from SΞQ ID n° 7705 PL-6699.1 2158S61 to No Hits found

2159101 #N/A Contig9 from gb|AAG02084.l|AF285416_2 (AF285416) XerC SEQ ID n° 7706 PL-1711.1 2159462 to m 47? [Pseudomonas aeruginosa]

2150463 SΞQ ID n~823 pir] |C8264l hypothetical protein XF1753

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 7707 PL-1710.1 2150558 to 22% (strain 9a5c) gb| AAF84562.1 | AΞ003998_4

2162078 (AE003998) hypothetical protein [Xylella fastidiosa] SΞQ ID n~822

Contig9 from SΞQ ID n° 7708 PL-6697.1 2162161 to m No Hits found

2162340 #N/A Contig9 from SEQ ID n° 7709 PL-1709.1 2162474 to m No Hits found

2163196 SΞQ ID n~820 Contig9 from ref |NP_052478.l| yccB [Plasmid Collb-P9]

SEQ ID n° 7710 PL-1708.1 2163344 to 47? dbj |BAA75117.l| (AB021078) yccB [Plasmid Collb-

2164264 P9] SBQ ID n~819 Contig9 from

SEQ ID n° 7711 PL-6696.1 2164394 to m No Hits found

2164582 #N/A

TABLEAU II

pir| |E82639 hypothetical protein XF1764

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 7712 PL-6694.1 2164671 to m 54% (strain 9a5c) gb|AAF84573.l|AE00.39_99_l

2165003 (AEO03999) hypothetical protein [Xylella fastidiosa] #N/A

Contig9 from SEQ ID n° 7713 PL-1707.1 2165069 to m No Hits found

2165980 SΞQ ID n~818 ref |NP_06668l.l| similar to ardC gène in

Contig9 from pSa(IncW plasmid) [Agrobacterium SEQ ID n° 7714 PL-1706.1 2166080 to m 19? rhizogenes] dbj |BAB16219.1 | (AP002086) similar

2168053 to ardC gène in pSadncW plasmid) [Agrobacterium rhizogenes] SEQ ID n~817

Contig9 from SΞQ ID n° 7715 PL-3860.1 2168121 to m No Hits found

2168666 SEQ ID n~3032 Contig9 from SEQ ID n° 7716 PL-6691.1 2168672 to m No Hits found

2168968 #N/A Contig9 from SEQ ID n° 7717 PL-6689.1 2168968 to m No Hits found

2169354 #N/A Contig9 from SΞQ ID n° 7718 PL-6687.1 2169367 to m No Hits found

2169588 #N/A Contig9 from SΞQ ID n° 7719 PL-6686.1 2169601 to m No Hits found

2169765 #N/A Contig9 from gb|AAK02039.l|AF261825_8 (AF261825) hypothetical SEQ ID n° 7720 PL-1705.1 2170208 to m 36? protein [Salmonella enterica subsp.

2171185 enterica serovar Typhimurium] SEQ ID n~816 Contig9 from SΞQ ID n° 7721 PL-6583.1 2171488 to m No Hits found

2171745 #N/A

TABLEAU II

pir| |F82543 outer membrane hemolysin activator protein XF2550 [imported] - Xylella

Contig9 from

-fastidiosa (strain 9a5c) SEQ ID n° 7722 PL-1704.1 2172577 to p 56? gb|AAF85347.l|AE004062_2 (AΞ004062) outer

2174241 membrane hemolysin activator protein [Xylella fastidiosa] SEQ ID n~815 pir| ]F81045 hemagglutinin/hemolysin-related protein NMB1768 [imported] -

Contig9 from

Neisseria meningitidis (group B strain MD58) SΞQ ID n° 7723 PL-1703.1 2174290 to p 37? gb|AAF42109.l| (AE002526)

2183103 hemagglutinin/hemolysin-related protein

[Neisseria meningitidis MC58] SEQ ID n~814 pir| |A82955 hypothetical protein PA5527

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 7724 PL-7420.1 2183112 to p 56% (strain PAOl) gb|AAG08912.l|AE004965_4

2183531 (AE004965) hypothetical protein [Pseudomonas aeruginosa] #N/A sp | P39394 | Y IW_ΞCOLI HYPOTHΞTICAL 14.6 KDA

PROTΞIN IN MCRB-HSDS INTBRGΞNIC RΞGION

(F132) pir||S56573 hypothetical 14.6K protein

Contig9 from

(mcrB-hsdS intergenic région) - SΞQ ID n° 7725 PL-7419.1 2183577 to m 41%

Ξscherichia coli gb| AA97244.l| (U14003)

2183819

0RF_fl32 [Ξscherichia coli] gb|AAC77303.l|

(AE000505) orf, hypothetical protein

[Escherichia coli K12] #N/A

Contig9 from emb|CAB53822.l| (AJ242593) putative repressor SΞQ ID n° 7726 PL-7417.1 2183918 to 29% protein [Bacteriophage A118]

2184253 #N/A

Sp|P4776 |PRIM_LISMO DNA PRIMASE gb | AAC43305.1 |

Contig9 from

(U13165) DNA primase [Listeria monocytogenes]

SΞQ ID n° 7727 PL-3.3 2184441 to 16% prf | |2104269B DNA primase [Listeria

2187755 monocytogenes] #N/A

Contig9 from gb|AAF89876.1 | (AF173869) putative site-specific SΞQ ID n° 7728 PL- 7415.1 2187742 to 33? recombinase XerD [Staphylococcus

2188872 aureus] #N/A

TABLEAU II

Contig9 from

SEQ ID n° 7729 PL-7412.1 2189065 to p No Hits found

2189196 #N/A

Contig9 from

SEQ ID n° 7730 PL-6918.2 2189424 to p No Hits found

2189690 #N/A

Contig9 from gb|AAK05486.l|AE006370_ll (AΞ006370) prophage

SEQ ID n° 7731 PL-3195.1 2189712 to p 30% pi3 protein 14 [Lactococcus lactis subsp.

2190398 lactis] SΞQ ID n-2445

Contig9 from

SΞQ ID n° 7732 PL-5715.1 2190388 to p No Hits found

2190651 #N/A

Contig9 from gb|AAC32470.l| (AF044501) unknown [Ξscherichia

SEQ ID n° 7733 PL-3194.1 2190726 to p 22% coli]

2191346 SΞQ ID n~2444

Contig9 from

SEQ ID n° 7734 PL-6930.1 2191811 to p No Hits found

2192722 #N/A

Contig9 from

SEQ ID n° 7735 PL-7411.1 2192719 to p No Hits found

2193036 #N/A sp|P39394|YJIW_ΞCOLI HYPOTHΞTICAL 14.6 KDA

PROTΞIN IN MCRB-HSDS INTΞRGΞNIC RΞGION

(F132) pir]|S56573 hypothetical 14.6K protein

Contig9 from

(mcrB-hsdS intergenic région) - SEQ ID n° 7736 PL-7410.1 2193081 to m 38?

Escherichia coli gb| AAA97244.l] (U14003)

2193323

0RF_fl32 [Ξscherichia coli] gb |AAC77303.1 |

(AΞ000505) orf, hypothetical protein

[Ξscherichia coli K12] #N/A

TABLEAU II

sp| 034419 |RSR1_VIBCH CRYPTIC PHAGE CTXPHI

TRANSCRIPTIONAL REPRESSOR RSTR pir| |H82197 transcription repressor RstR VC1464 VC1455

[imported] - Vibrio cholerae (group

Contig9 from

01 Strain N16961) gb|AAB8172 .1 | (U83795) RstR SEQ ID n° 7737 PL-7409.1 2193416 to 48?

[Vibrio cholerae] gb|AAB81728. l| (U83796) RstR - - — 2193787

[Vibrio cholerae] gb|AAF94612.1] (AΞ0Ô4224) ^{~ ~} transcriptional repressor RstR [Vibrio cholerae] gb|AAF94621.l| (AΞ004224) transcriptional repressor RstR [Vibrio cholerae] #N/A sp | P47762 | PRIM_LISMO DNA PRIMASΞ gb | AAC43305.1 |

Contig9 from

(U13165) DNA primase [Listeria monocytogenes] SEQ ID n° 7738 PL-7408.1 2193887 to p 17% prf | |2104269B DNA primase [Listeria

2197201 monocytogenes] #N/A pir| |F83177 integrase/reco binase XerD PA3738

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 7739 PL-6943.3 2197188 to p 38% (Strain PAOl) gb] AG07125. l| AΞ004793_2

2198300 (AΞ004793) integrase/recombinase XerD

[Pseudomonas aeruginosa] #N/A

Contig9 from emb|CAB65124.l| (AJ007421) spalt-like zinc SEQ ID n° 7740 PL-3517.1 2198676 to p 29% finger protein [Homo sapiens]

2199131 SEQ ID n~2728 Contig9 from SEQ ID n° 7741 PL-417.1 2199153 to p No Hits found

2200007 SEQ ID n~3223 Contig9 from SEQ ID n° 7742 PL-5725.1 2200004 to p No Hits found

2200309 #N/A ContigS from SEQ ID n» 7743 PL-418.1 2200451 to p No Hits found

2201326 SEQ ID n~3224 Contig9 from SΞQ ID n° 7744 PL-419.1 2201691 to p No Hits found

2202488 SEQ ID n~S225

TABLEAU II

ref |NP_047570.l| unknown [Yersinia pestis] pir| |T42852 hypothetical protein Y0012 -

Yersinia pestis plasmid pCDl gb| AAC69767.l|

(AF074612) unknown [Yersinia pestis]

Contig9 from emb|CAB54945.l| (AL117189) YPCD1.68C, Y0012, SEQ ID n° 7745 PL-572S.1 2202674 to p 38% hypothetical protein, len: 68 aa;

2202841 identical to corresponding CDS from Y.pestis

KIM5 pCDl (EMBL:AF074612) (68 aa) , fasta scores, opt: 453 z-score; 678.

E(): 2e-30 98.5% identity in 68 aa overlap.

Similar to parts of hypothe> #N/A

Contig9 from gb|AAG61082.l[AF322013_201 (AF322013J ID930

SEQ ID n° 7746 PL-5730.1 2202949 to m 33% [Bradyrhizobium japonicum]

2203218 #N/A

Contig9 from gb|AAC26596.l| (U83995) putative protease

SEQ ID n° 7747 PL-420.1 2203330 to 59% [Porphyromonas gingivalis]

2204214 SEQ ID n~3227

Contig9 from gb|AAG61082.l|AF322013_201 (AF322013) ID930

SEQ ID n° 7748 PL-421.1 2204227 to m 65? [Bradyrhizobium japonicum]

2209602 SEQ ID n~3228

Contig9 from pdb|lF3l|A Chain A, Crystal Structure Of Tn5

SEQ ID n° 7749 PL-422.1 2209603 to m 57? Transposase Complexed With Transposon

2210985 Ξnd Dna SEQ ID n~3229 pir| ]T14593 syringomycin synthetase -

Contig9 from Pseudomonas syringae pv. syringae SEQ ID n° 7750 PL-423.1 2210996 to 54% gb|AAC80285.l] (AF047828) syringomycin

2225947 synthetase [Pseudomonas syringae pv. syringae] SEQ ID n~3230

Contig9 from gb[AAC82519.l| (AF027768) RetA [Serratia

SEQ ID n° 7751 PL-424.1 2226513 to 31? marcescens]

2227115 SEQ ID n~3231

Contig9 from gb|AAG61023.l|AF322013_142 (AF322013) ID776

SEQ ID n° 7752 PL-425.1 2227070 to 62? [Bradyrhizobium japonicum]

2228479 SΞQ ID n~3232

TABLEAU II

Contig9 from SEQ ID n° 7753 PL-5745.1 2228476 to m No Hits found

2228676 #N/A Contig9 from gb|AAC825l9.l| (AF027768) RetA [Serratia SEQ ID n° 7754 PL-426.1 2228857 to m 58% marcescens]

2229330 SEQ ID n~3233 Contig9 from gb | AAG60892 . l |AF322013_ll (AF322013 ) ID 59 SEQ ID n° 7755 PL-5748.1 2229477 to m 52% [Bradyrhizobium japonicum]

2229746 #N/A Contig9 from dbj |BAB16031.l| (AB030747) transposase SEQ ID n° 7756 PL-427.1 2230262 to 40% [Streptococcus pyogenes]

2230837 SEQ ID n~3234 sp | 20932 | MDLB_PSΞPU L (+) -MANDΞLATE

Contig9 from DΞHYDROGΞNASΞ (S-MANDELATE DEHYDROGENASE) (MDH) SΞQ ID n° 7757 PL-428.1 2230991 to 67% pir| |B44767 L-mandelate dehydrogenase (EC 1.1.2.'

2232139 ) - Pseudomonas putida gb|AAC15503. l| (J05293)

S-mandelate dehydrogenase [Pseudomonas putida] SEQ ID n~3235 pir| |T36319 probable aminotransferase -

Contig9 from Streptomyces coelicolor (fragment) SΞQ ID n° 7758 PL-429.1 2232383 to m 54? emb|CAB38598.l| (AL035654) putative

2233675 aminotransferase [Streptomyces coelicolor

A3 (2)] SEQ ID n~3236 pir| |E75215 glyoxalase I related protein PAB2438

[imported] - Pyrococcus abyssi

Contig9 from

(strain Orsay) emb| CAB49172.1 | (AJ248283) SEQ ID n° 7759 PL-3526.1 2233697 to m 37?

LACTOYLGLUTATHIONΞ LYASE (EC 4.4.1.5)

2234287

METHYLGLYOXALASE) (ALDOKETOMUTASE)

(GLYOXALASE I) . [Pyrococcus abyssi] SEQ ID n~2731

Contig9 from gb|AAG02359.l|AF210249_18 (AF21024S) peptide SEQ ID n° 7760 PL-7190.1 2234340 to m 46% synthetase NRPS5-4-3 [Streptomyces

2234543 verticillus] #N/A Contig9 from SΞQ ID n° 7761 PL-5752.1 2234568 to No Hits found

2234705 #N/A

m !

S^' s^"

41= fc o

H σ

H

Ό ^•d i α d fi d a P P P p P P o o o O o o m ta to M ta

-U 4-1 -H -ri •H -ri -ri a œ œ w K ta o o o 0 o o s Ά S ft ft ft ft ft ft

E B E ε B ε B ε

0 0 o 0 O 0 0 0 0 o O 0 0 0 0 o o o

M o M M -P

W en m ro o t'H ro en en en o m eo en ro en en en ro en tn tn tn tn r--

-ri tn tn tn

-* n ro -ri ro -ri ro n -ir r m J ro " ro ro ro ro ro es ro ro es d d °< ri ci i Ci es Ci i es es

O es o 0 0 O O 0 es 0 es o O u α u U υ u u

H >-! H H

ro en σ r-

H r- r~ r^ r- r- r- r- c- r- ι H o

§ c! fi fi ci i fi ci

H Q P R P P P P P H H H H H H H H α CH σ σ o> c»

H P-l m w H P-l M H w m to ω ω ω ro en CN ro ro ro ^ •Φ r~ es es CN CN CO î «a! ! ! - ! ! fi ^"a fi Ci f

53 fi fe fi i

^"a

P # P # O P # P P

H H H H H α CX α ex σ

Pfl H H w H H en W CQ CQ

X) T) Tf ^•d ^•d Ό -d T⁾ fi p fi fi fi fi fi fi

P P fi P P fi P P

0 O o 0 0 o o o o

ft ε o ε o ε o o ε 0 0 ε 0 ε u 0 0 0

-M M M 4-1

M-l co M-l H μ 4-1 o

<# LO en es es r- ^ oo M-l ro CO en co en •* en m co en in H en o en en en o LO en 00 O en en tn co tn LO tn en tn -# tn oo es en ro en es CD b) LO [ tn en 00 -ri c- -ri CD • O -ri o -ri es -ri ro -ri ro

4-1 ro ro es •y •tf s -ri CD φ CN -ri D • e 4-1 > 4J ^ CN fi ci es ci es ti es Ci es es ci CN es o O CS o 0 es o fi o es es

0 es o o u u Ό U u es

H es ro r- en o r- r r r- r r 03

H l ! r- t^ r

H r- » ι r r-

Pu P Q p P α P R P R R P

H H H H H H H H H H σ α a σ σ α Ol w m α σ o ω w M w H t to to TABLEAU II

Contig9 from

SEQ ID n° 7781 PL-437.1 2248466 to m No Hits found

2249389 SΞQ ID n~3244

Contig9 from

SΞQ ID n° 7782 PL-5770.1 2250039 to m No Hits found

2250416 #N/A

Contig9 from

SEQ ID n° 7783 PL-5771.1 2250435 to m No Hits found

2250821 #N/A

Contig9 from

SΞQ ID n° 7784 PL-5772.1 2250861 to m No Hits found

22510S7 #N/A

ContigS from

SΞQ ID n° 7785 PL-5773.1 2251094 to m No Hits found

2251369 #N/A ref |NP_054630.1] transposon gamma-delta resolvase (transposon TN1000) homolog

[Yersinia pestis] ref [NP_04763 .1 | putative resolvase [Yersinia pestis] pir| |T43611

Contig9 from probable resolvase tnpR - Yersinia pestis SΞQ ID n° 7786 PL-5775.1 2251651 to 38? plasmid pCDl gb|AAC62593.l| (AF053946)

2251884 transposon gamma-delta resolvase (transposon

TN1000) homolog [Yersinia pestis] gb|AAC69824.l| (AF074612) putative resolvase

[Yersinia pestis] emb|CAB54968.l| (AL117189) putative resolvase [Yersinia pestis] m/A

Contig9 from dbj |BAA89622.l| (AB036665) similar to Ξ.coli

SEQ ID n° 7787 PL-439.1 2251887 to 66\ hypothetical protein o375

2252957 [bacteriophage WO] SΞQ ID n~3245

Contig9 from

SEQ ID n° 7788 PL-440.1 2253167 to No Hits found

2253919 SEQ ID n~3247

Contig9 from

SEQ ID n° 7789 PL-5776.1 2253900 to No Hits found

2254109 #N/A

TABLΞAU II

ContigS from pdb|lF3l|A Chain A, Crystal Structure Of Tn5

SEQ ID n° 7790 PL-441.1 2254239 to 57 Transposase Complexed With Transposon

2255621 Ξnd Dna SΞQ ID n~3248 ref |NP_058332.1 | orf; hypothetical protein

ContigS from [Salmonella typhi] gb| AAF69957.1 | F250878_118

SEQ ID n° 7791 PL-442.1 22555S6 to m 373 (AF250878) orf; hypothetical protein [Salmonella

2257554 typhi] SEQ ID n~3249

Contig9 from

SEQ ID n° 7792 PL-3531.1 2257658 to m No Hits found

2258104 SEQ ID n~2735

ContigS from pir| |G71704 hypothetical protein RP457 -

SEQ ID n° 7793 PL-443.1 2258200 to m 35% Rickettsia prowazekii emb|CAA14913.l|

2258772 (AJ235271) unknown [Rickettsia prowazekii] SEQ ID n~3250

Contig9 from

SEQ ID n° 7794 PL-444.1 2258802 to m No Hits found

2259539 SEQ ID n~3251

Contig9 from

SEQ ID n° 7795 PL-445.1 2259542 to No Hits found

2260342 SEQ ID n~3252

Contig9 from

SEQ ID n° 7796 PL-5780.1 2260726 to m No Hits found 2260911 #N/A ref |NP_061700.l| conserved hypothetical protein

[Xylella fastidiosa] pir| ]D82866 conserved

ContigS from hypothetical protein XFa0θ45 [imported] - SΞQ ID n° 7797 PL-5781.1 2260994 to 64%

Xylella fastidiosa (strain 9a5c)

2261311 gb|AAF85613.l|AE003851_44 (AE003851) conserved hypothetical protein [Xylella fastidiosa] #N/A ref |NP_061701.l| hypothetical protein [Xylella fastidiosa] pir| |Ξ82866 hypothetical protein

Contig9 from

XFa0046 [imported] - Xylella fastidiosa SΞQ ID n° 7798 PL-5782.1 2261314 to 51%

(Strain 9a5c) gb[AAF85614.l|AE003851_45

2261625

(AΞ003851) hypothetical protein [Xylella fastidiosa] #N/A

TABLEAU II

Contig9 from

SEQ ID n^» 7799 PL-5785.1 2261768 to m No Hits found

2262013 #N/A

Contig9 from

SEQ ID n° 7800 PL-5786.1 2262234 to m No Hits found

2262461 #N/A

Contig9 from ref |NP_053113.l| orf51 [Escherichia coli]

SΞQ ID n° 7801 PL-446.1 2262494 to m 53% dbj |BAA84886.l| (AB024946) orf51 [Escherichia

2263999 coli] SEQ ID n~S253 gb|AAG55308.l(AΞ005273_l (AE005273) unknown in

Contig9 from

ISΞC8 [Ξscherichia coli 0157 :H7]

SΞQ ID n° 7802 PL-5788.1 2264063 to 733 gb|AAG55717.l[AE005309_7 (AE005309) unknown in

2264398

ISEcδ [Ξscherichia coli 0157 :H7] #N/A

Contig9 from

SΞQ ID n° 7803 PL-5789.1 2264392 to No Hits found

2264757 #N/A

Contig9 from sp|P09750|SHU6_ECOLI SHUFFLON PROTΞIN C

SΞQ ID n° 7804 PL-447.1 2265051 to m 64% pir(|F26421 shufflon C - Escherichia coli

2266229 plasmid R64 SEQ ID n~3254

Contig9 from dbj |BAA77981.l| (AB027308) prepilin peptidase

SEQ ID n° 7805 PL-448.1 22662S5 to 603 [Plasmid R64]

2266960 SEQ ID n~3255

Contig9 from dbj |BAA77979.1 (AB027308) type IV prepilin

SEQ ID n° 7806 PL-449.1 2266961 to 66 [Plasmid R64]

2267563 SEQ ID n~3256 ref |NP_052542.l| intégral membrane protein

Contig9 from [Plasmid CθlIb-P9] dbj |BAA75181.l| (AB021078) SEQ ID n° 7807 PL-450.1 2267632 to m 693 intégral membrane protein [Plasmid ColIb-P9]

2268717 dbj |BAA77978.l| (AB027308) intégral membrane protein [Plasmid R64] SEQ ID n~3258

Contig9 from gb|AAF81213.l|AF247502_8 (AF247502) PilQ SEQ ID n° 7808 PL-451.1 2268710 to m 12-' [Salmonella dublin]

2270263 SΞQ ID n~3259 Contig9 from gb|AAFl48l6.l| (AF000001) PilP [Salmonella SEQ ID n° 7809 PL-3535.1 2270277 to 42% typhi] gb|AAF81212.l[AF247502_7 (AF247502) PilP

2270741 [Salmonella dublin] SΞQ ID n~2737

TABLEAU II

ContigS from gb|AAF14815.2| (AF000001) PilO [Salmonella SEQ ID n° 7810 PL-452.1 2270749 to m 523 typhi] gb|AAF81211.l|AF247502_6 (AF247502) PilO

2272065 [Salmonella dublin] SΞQ ID n~3260 ref |NP_052546.1 [ lipoprotein [Plasmid ColIb-P9]

Contig9 from dbj |BAA75185.l| (AB021078) lipoprotein [Plasmid SEQ ID n° 7811 PL-453.1 2272089 to m 72%

CθlIb-P9] dbj |BAA77974.l| (AB027308)

2273792 lipoprotein [Plasmid R64] SΞQ ID n~3261

Contig9 from gb[AAF81208.l|AF247502_3 (AF247502) PilM SEQ ID n° 7812 PL-5796.1 2273811 to 563 [Salmonella dublin]

2274248 #N/A ContigS from gb|AAFi48l2.2 | (AF000001) PilL [Salmonella SEQ ID n° 7813 PL-454.1 2274255 to 653 typhi] gb|AAF81207.l|AF247502_2 (AF247502) PilL

2275304 [Salmonella dublin] SΞQ ID n~3262 Contig9 from SΞQ ID n° 7814 PL-5800.1 2275452 to m No Hits found

2275661 #N/A Contig9 from SEQ ID n° 7815 PL-5801.1 2275685 to m No Hits found

2276014 #N/A pir| |G82648 conserved hypothetical protein

Contig9 from XF1702 [imported] - Xylella fastidiosa SEQ ID n° 7816 PL-5802.1 2276318 to p 75% (strain 9a5c) gb [AAF84511.I| AΞ003994_10

2276506 (AE003994) conserved hypothetical protein

[Xylella fastidiosa] /A

Contig9 from SEQ ID n° 7817 PL-5803.1 2276585 to m No Hits found

2276833 #N/A Contig9 from SEQ ID n° 7818 PL-7184.1 2277367 to m No Hits found

2277603 #N/A Contig9 from SEQ ID n° 7819 PL-455.1 2277739 to p No Hits found

2278632 SEQ ID n~S263 Contig9 from SΞQ ID n° 7820 PL-456.1 2278750 to p No Hits found

2279532 SEQ ID n~3264

TABLEAU II

pir| |A83438 serine/threonine phosphoprotein phosphatase Stpl PA1670 [imported]

Contig9 from

Pseudomonas aeruginosa (strain PAOl) SEQ ID n° 7821 PL-457.1 2279519 to 33% gb|AAG05059.l|AΞ004594__ll (AΞ004594)

2280187 serine/threonine phosphoprotein phosphatase Stpl

[Pseudomonas aeruginosa] SΞQ ID n~3265 sp | 28046 | SSB_PROMI^~SINGLE-STRAND BINDING

PROTEIN (SSB) (HBLIX-DΞSTABILIZING PROTΞIN)

Contig9 from pir| |S19955 single-stranded DNA-binding protein SEQ ID n° 7822 PL-3536.1 2280912 to m 82%

Proteus mirabilis emb|CAA46206.l( (X65079)

2281376 single-stranded DNA-binding protein [Proteus mirabilis] SΞQ ID n~2738 pir| |C82642 hypothetical protein XF1761

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 7823 PL-3537.1 2281450 to m 39% (strain 9a5c) gb |AAF84570.1 | AΞ003998_12

2281908 (AE003998) hypothetical protein [Xylella fastidiosa] SEQ ID n~273S

Contig9 from gb(AAF14809.l| (AF000001) topoisomerase B SΞQ ID n° 7824 PL-459.1 2282568 to m 763 [Salmonella typhi]

2284598 SΞQ ID n~3267 pir||E82638 hypothetical protein XF1780

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 7825 PL-460.1 2284602 to 463 (strain 9a5c) gb|AAF84588.1 | AΞ004000_5

2285300 (AΞ004000) hypothetical protein [Xylella fastidiosa] SΞQ ID n~3269 pir| |F82638 hypothetical protein XF1781

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 7826 PL-461.1 2285569 to m 43*i (strain 9a5c) gb|AAF84589.l| AΞ004000_6

2286804 (AΞ004000) hypothetical protein [Xylella fastidiosa] SEQ ID n~3270

Contig9 from SEQ ID n° 7827 PL-5815.1 2286821 to m No Hits found

2287084 #N/A

TABLEAU II

pir| |T17449 hypothetical 21.9K protein

Contig9 from [imported] - Yersinia pestis gb| AAC69594.l| SEQ ID n° 7828 PL-3538.1 2287081 to m 52% (AF091251) unknown [Yersinia pestis]

2287671 emb|CAA21400.l[ (AL031866) ORF 77, len=192 aa, unknown [Yersinia pestis] SEQ ID n~2740 ref |NP_052955.l| 100% identical to gp:AF005044_3 [TraR of plasmid R100-1, function

Contig9 from unknown] [Plasmid R100] gb| AB61930.l| SEQ ID n° 7829 PL-5817.1 2287735 to m 423 (AF005044) TraR [Escherichia coli]

2287986 dbj |BAA78859.l| (AP000342) 100% identical to gp:AF005044_3 [TraR of plasmid R100-1, function unknown] [Plasmid R100] #N/A pir| |A82639 hypothetical protein XF1784

Contig9 from [imported] - Xylella fastidiosa SΞQ ID n° 7830 PL-462.1 2287979 to m 233 (strain 9a5c) gb|AAF84592.l|AE004000_9

2289709 (AE004000) hypothetical protein [Xylella fastidiosa] SEQ ID n~3271

Contig9 from SEQ ID n° 7831 PL-463.1 2289705 to m 673 sp|P10338|DNAB_SALTY REPLICATIVΞ DNA HΞLICASE

2291085 SEQ ID n~3272 pir| |B82639 chromosome partitioning related protein XF1785 [imported] - Xylella

Contig9 from fastidiosa (strain 9a5c) SEQ ID n° 7832 PL-464.1 2291078 to m 57% gb|AAF84593.1 | AΞ004000_10 (AΞ004000) chromosome

2291962 partitioning related protein [xylella fastidiosa] SEQ ID n~3273

Conti g 9 from gb|AAG02084.l|AF285416_2 (AF285416) XerC SEQ ID n° 7833 PL-465.1 2292497 to m 47% [Pseudomonas aeruginosa]

2293498 SEQ ID n~3274 pir[ |C82641 hypothetical protein XF1753

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 7834 PL-466.1 2293576 to m 20% (Strain 9a5c) gb|AAF84562 -l|AE003998_4

2295117 (AE003998) hypothetical protein [Xylella fastidiosa] SΞQ ID n-3275

TABLBAU II

ContigS from

SΞQ ID n° 7835 PL-5820.1 2295620 to m No Hits found

_ 295724 #N/A .

ContigS from ref |NP_052478.l| yccB [Plasmid Collb-P9]

SΞQ ID n° 7836 PL-467.1 2295817 to m 473 dbj |BAA75117.l| (AB021078) yccB [Plasmid Collb-

2296740 P9] SΞQ ID n~3276

Contig9 from

SEQ ID n° 7837 PL-5823.1 2296870 to m No Hits found

2297118 #N/A

Contig9 from

SEQ ID n° 7838 PL-468.1 2297168 to m No Hits found

2298181 SΞQ ID n~3277

Contig9 from pir| |T00225 hypothetical protein - Ξscherichia

SEQ ID n° 7839 PL-469.1 2298015 to 633 coli plasmid p0157

2298842 SEQ ID n~3278

Contig9 from sp[P39213 [YI91_SHIDY INSΞRTION ELEMΞNT IS911

SΞQ ID n° 7840 PL-5824.1 2298869 to m 803 HYPOTHΞTICAL 12.7 KD PROTΞIN

2299171 #N/A

ContigS from

SEQ ID n° 7841 PL-5825.1 2299226 to m No Hits found

2299414 #N/A

Contig9 from gb|AAG60892.l|AF322013_ll (AF322013) ID459

SΞQ ID n° 7842 PL-5827.1 2299906 to 523 [Bradyrhizobium japonicum]

2300175 #N/A

Contig9 from gb|AAC82519.l| (AF027768) RetA [Serratia

SEQ ID n° 7843 PL-470.1 2300323 to 693 marcescens]

2301102 SΞQ ID n~3280

Contigθ from gb|AAG60892.l|AF322013_ll (AF322013) ID459

SEQ ID n° 7844 PL-471.1 2301099 to 14% [Bradyrhizobium japonicum]

2301683 SΞQ ID n~3281

Contig9 from sp|P55606|Y4OU_RHISN HYPOTHΞTICAL PROTΞIN Y40U

SΞQ ID n° 7845 PL-473.1 2302258 to 493 PRECURSOR gb|AAB91807.l| (AΞ000089) Y4θU

2302992 [Rhizobium sp. NGR234] SEQ ID n~3283

ContigS from

SΞQ ID n° 7846 PL-5830.1 2303602 to m No Hits found

2303820 #N/A

α C» α C» O σ

H m W W w w w m m

O ^•O O ^•d fi fi fi fi

0 O fi O O O o

Ή

ft ft ft ft

ro

o o o o g fi C! fi fi fi ύ ϋ fi fi fi fi

P P P P R R P P P Q P

H H H H H H H H H H H

CH Ol σ en o< α o> σ α O Ol m Cq m m H M W m w H B) ta to Ul en ro ro ro ro ro W ro TABLEAU II

sp | P37610 | TAUD_ECOLI ALPHA-KΞTOGLUTARATΞ-

DEPENDENT TAURINE DIOXYGENASE (SULFATE

STARVATION-INDUCED PROTEIN 3) (SSI3) pir| |H64764 probable taurine dioxygenase (ΞC 1.-

Contig9 from

.-.-) - Escherichia coli dbj (BAA12841.l[ SEQ ID n° 7858 PL-478.1 2312213 to m 50

(D85613) dioxygenase [Ξscherichia coli]

2313160 gb|AAB18091.l| (U73857) dioxygenase [Escherichia coli] gb|AAC73471.l| (AEO 00143) taurine dioxygenase , -oxoglutarate-dependent

[Escherichia coli K12] SΞQ ID n~3288

Contig9 from gb[AABl8065.l| (U73857) cyanate transport SEQ ID n° 7859 PL-479.1 2313195 to m 41% protein [Ξscherichia coli]

2314406 SΞQ ID n~3289 pir||C83589 conserved hypothetical protein

Contig9 from PA0446 [imported] - Pseudomonas SEQ ID n° 7860 PL-480.1 2314531 to m 56% aeruginosa (strain PAOl)

2315715 gb|AAG03835.l|AE004482_2 (AE004482) conserved hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~3291

Contig9 from gb|AAD12608.l| [AF036940) salicylate-5- SEQ ID n° 7861 PL-3542.1 2316032 to m 49% hydroxylase small oxygenase component

2316481 [Ralstonia sp. U2] SΞQ ID n~2744 Contig9 from gb|AAD12607.l| (AF036940) salicylate-5- SEQ ID n° 7862 PL-481.1 2316510 to m 63% hydroxylase large oxygenase component

2317718 [Ralstonia sp. U2] SΞQ ID n~3292 Contig9 from pir| |C71664 hypothetical protein RP592 - SEQ ID n° 7863 PL-482.1 2317729 to m 29% Rickettsia prowazekii emb| CAA15037.1 |

2318823 (AJ235272) unknown [Rickettsia prowazekii] SΞQ ID n~3293 Contig9 from gb|AAG02168.l|AF212041_24 (AF212041) 3-oxoacyl- SEQ ID n° 7864 PL-5842.1 2319369 to m 25% (acylcarrier protein) reductase [Zy omonas

2319662 mobilis] #N/A Contig9 from gb |AAG58930 . l | AE005604_7 (AE005604) putative SEQ ID n° 7865 PL-3543.1 2321108 to p 54% major fimbrial subuit [Ξscherichia coli

2321617 0157 :H7] SΞQ ID n~2745

TABLΞAU II

sp|P42914|YRAI_EC0LI HYPOTHETICAL 25.7 KD

FIMBRIAL CHAPERONΞ IN AGAI-MTR INTERGENIC

REGION PRECURSOR pir]|C65104 hypothetical 25.7

Contig9 from kD fimbrial chaperone in agai- mtr intergeni - SEQ ID n° 7866 PL-483.1 2321674 to p 54°

Escherichia coli (strain K-12) gb|AAA57946.1 |

2322342

(U18997) ORF_o231 [Ξscherichia coli] gb|AAC76177.l| ^" (AE0Ou395) putative chaperone

[Escherichia coli K12] SEQ ID n~3294

Contig9 from gb|AAG58277.l|AΞ005543_7 (AE005543) putative SΞQ ID n° 7867 PL-484.1 2322348 to p 56% outer membrane protein [Escherichia coli

2324861 0157 :H7] SEQ ID n~3295 sp|P216 8|MRKD_KLΞPN FIMBRIA ADHESIN PROTEIN

PRΞCURSOR pir| |B32801 fimbrial adhesin

Contig9 from precursor, type 3 - Klebsiella pneumoniae SEQ ID n° 7868 PL-485.1 2324889 to p 18% gb|AAA25096.l| (M55912) mrkD [Klebsiella

2325869 pneumoniae] gb|AAA25098.1 [ (M24536) fimbrial adhesin [Klebsiella pneumoniae] SEQ ID n~3296 sp|P12903|FM12_KLΞPN FIMBRIAL SUBUNIT TYPE 1

Contig9 from PRECURSOR pir| |YQKBT1 type 1 fimbrial protein SEQ ID n° 7869 PL-486.1 2326277 to p 20Î precursor - Klebsiella pneumoniae (strain

2327287 IA565) gb|AAA25091.l| (M20917) major fimbrial subunit precursor [Klebsiella pneumoniae] SEQ ID n~3297 pir||B83501 hypothetical protein PA1165

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 7870 PL-487.1 2327333 to p 411 (strain PAOl) gb|AAG04554.1 | AE004546_9

2328076 (AE004546) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~3298 sp | QO7095 | HPCRJ3C0LI H0M0PR0T0CATΞCHUATE

DΞGRADATIVΞ OPΞRON RΞPRΞSSOR pir| |S30280 hpcR protein - Ξscherichia coli gb|AAB25801.1 |

Contig9 from (S56952) Hpc repressor [Escherichia coli, C, SEQ ID n° 7871 PL-3544.1 2328153 to m 77% Peptide, 148 aa] emb| CAA86039.1 | (Z37980)

2328599 regulator of the meta operon of 3 , 4dhpa metabolic pathway [Ξscherichia coli] prf | |l912302A homoprotocatechuate dégradation operon regulator [Escherichia coli] SEQ ID n~2746

TABLEAU II

sp | Q9RPU5 | HPAG_SALDU -HYDROXYPHΞNYLACETATE

DEGRADATION BIFUNCTIONAL

ISOMERASE/DECARBOXYLASE [INCLUDES: 2-

Contig9 from HYDROXYHEPTA-2 , 4-DIENE-1,7-DIOATE ISOMERASE SEQ ID n° 7872 PL-488.1 2328986 to p 76% (HHDD ISOMERASE) ; 5-CARBOXYMETHYL-2-

2329618 OXO-HEX-3-ENE-1, 7-DIOATE

DECARBOXYLASE (OPET DECARBOXYLASE) ] gb|AAD53501.l|AF144422_8 (AF144422) HpaG

[Salmonella dublin] SΞQ ID n~3299 pir[|G83l3l conserved hypothetical protein

Contig9 from PA4122 [imported] - Pseudomonas BEQ ID n° 7873 PL-489.1 2329471 to p 68% aeruginosa (strain PAOl)

2330376 gb|AAG07509.l|AE004828_10 (AE004828) conserved hypothetical protein [ seudomonas aeruginosa] SΞQ ID n~3300

Contig9 from emb|CAA86041.l[ (Z37980) 5-carboxy-2- SΞQ ID n° 7874 PL-490.1 2330376 to p 95% hydroxymuconate semialdehyde dehydrogenase

2331842 [Ξscherichia coli] SΞQ ID n~3302 Contig9 from gb|AAD53499.l|AF144422_6 (AF144422) HpaD SΞQ ID n° 7875 PL-491.1 2331907 to p 80% [Salmonella dublin]

2332785 SΞQ ID n~3303 Contig9 from gb|AAD53498.l|AF144422_5 (AF144422) HpaF SEQ ID n° 7876 PL-3547.1 2332799 to p 69% [Salmonella dublin]

2333185 SΞQ ID n~2747 Contig9 from gb|AAK03617.l| (AE006190) Bcr [Pasteurella SEQ ID n° 7877 PL-492.1 2333188 to p 54% multocida]

2334417 SΞQ ID n~3304 pir| |D83613 succinate-semialdehyde dehydrogenase

PA0265 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 7878 PL-493.1 2334407 to 79% gb[AAG03654.l|AΞ004464_7 (AE004464) succinate-

2335879 semialdehyde dehydrogenase [Pseudomonas aeruginosa] SEQ ID n~3305 emb|CAA86044.l| (Z37980) 2-oxo-hept-3-ene-l, 7-

Contig9 from dioate hydratase [Escherichia coli] SΞQ ID n° 7879 PL-494.1 2335884 to p 88 gb|AAB91474.l( (AF036583) 2-oxo-hept-4-ene-l, 7-

2336687 dioate hydratase [Escherichia coli] SEQ ID n~3306

TABLBAU II

s I Q9RPV0 I HPAI_SALDU 2 , 4-DIHYDR0XYHEPT-2-ΞNE-1, 7-

Contig9 from

DIOIC ACID ALDOLASE (HHED ALDOLASE) SΞQ ID n° 7880 PL-495.1 2336699 to 78% gb|AAD53496.l|AF144422_3 (AF144422) Hpal

- 2337505

[Salmonella dublin] SΞQ ID n~3307

Contig9 from gb|AAD53495.l|AF144422_2 (AF144422) HpaX

SEQ ID n° 7881 PL-496.1 2337602 to p 81 - - [Salmonella dublin]

2338978 SΞQ ID n~3308

Contig9 from gb|AAD53494.l|AF144422_l (AF144422) HpaA

SΞQ ID n° 7882 PL-497.1 2339004 to 11% [Salmonella dublin]

2339894 SEQ ID n~3309

Sp|P39 84|YJEO_ECOLI HYPOTHETICAL 12.6 KD

PROTEIN IN GENX-PSD INTERGENIC REGION (O104B)

Contig9 from pir||S56386 hypothetical 12.6K protein (genx-psd SEQ ID n° 7883 PL-5849.1 2340332 to 47% intergenic région) - Escherichia coli

2340643 gb|AAA97057.l| (U14003) θRF_ol04b [Escherichia

COli] gb|AAC77118.l| (AE000488) orf, hypothetical protein [Escherichia coli K12] #N/A

Contig9 from SΞQ ID n° 7884 PL-5850.1 2341255 to No Hits found

2341575 #N/A Contig9 from SΞQ ID n° 7885 PL-5851.1 2341617 to No Hits found

2341940 #N/A sp|PS2037|YGFF_ΞCOLI HYPOTHΞTICAL OXIDORΞDUCTASΞ

Contig9 from IN BGLA-GCVP INTΞRGENIC RΞGION pir| JF65074 SEQ ID n° 7886 PL-498.1 2342300 to 76% hypothetical oxidoreductase - Ξscherichia coli

2343046 (strain K-12) gb| AAC75940.1 | (AΞ000373) putative oxidoreductase [Ξscherichia coli K12] SΞQ ID n~3310

Contig9 from SEQ ID n° 7887 PL-7176.1 2343185 to No Hits found

2343310 #N/A Contig9 from gb|AAC38630.l| (AF047028) insecticidal toxin SEQ ID n° 7888 PL-499.1 2343314 to 611 complex protein TccC [Photorhabdus

2346193 luminescens] SΞQ ID n~3311

TABLEAU II

Contig9 from gb|AAC08739.l| (AF021839) 4-hydroxyphenylacetic SEQ ID n° 7889 PL-500.1 2346515 to 94° acid hydroxylase [Photorhabdus

2348077 luminescens] SΞQ ID n~3314 Contig9 from gb|AAC08740.l| (AF021839) 4-hydroxyphenylacetic SEQ ID n° 7890 PL-3549.1 2348097 to 87% acid hydroxylase putative coupling

2348615 protein [Photorhabdus luminescens] SΞQ ID n~2749 sp|P36837|YHIP_ECOLÎ^"HYPOTHΞTICAL 53.7 KD

PROTEIN IN USPA-PRLC INTERGENIC REGION

Contig9 from pir( |C65147 hypothetical 53.7 kD protein in uspa- SEQ ID n° 7891 PL-501.1 2349085 to 86° prie intergenic région - Escherichia

2350554 coli (strain K-12) ^~ gb|AAC76521.1 | (AE000426) putative transport protein [Ξscherichia coli

K12] SΞQ ID n~S315 pir| |T33131 hypothetical protein C23H5.1 -

Contig9 from Caenorhabditis elegans gb |AAC17532.1 |

SΞQ ID n° 7892 PL-502.1 2350690 to m 40^e (AF067609) contains similarity to

2351409 methyltransferases [Caenorhabditis elegans] SΞQ ID n~3316

Contig9 from gb|AAF05542.l|AF188483_l (AF188483) toxin A SEQ ID n° 7893 PL-503.1 2352217 to 38° [Photorhabdus luminescens]

2358864 SΞQ ID n~3317 Contig9 from gb|AAF05542.l|AF188483_l (AF188483) toxin A SEQ ID n° 7894 PL-504.1 2359337 to 67^ [Photorhabdus luminescens]

2366671 SEQ ID n~3318 Contig9 from gb|AAC38625.l| (AF046867) insecticidal toxin SEQ ID n° 7895 PL-505.1 2366728 to 72° complex protein TcaC [Photorhabdus

2371155 luminescens] SEQ ID n~3319 Contig9 from SEQ ID n° 7896 PL-5857.1 2371171 to p No Hits found

2371302 #N/A Contig9 from gb|AAG55972.l|AΞ005330_4 (AE005330) putative SEQ ID n° 7897 PL-5859.1 2371208 to 53% holin protein of prophage CP-933X

2371528 [Ξscherichia coli 0157 :H7] #N/A Contig9 from gb|AAC38630.l| (AF047028) insecticidal toxin SEQ ID n° 7898 PL-506.1 2371677 to p 61% complex protein TccC [Photorhabdus

2374589 luminescens] SEQ ID n~3320

TABLΞAU II

Contig9 from gb|AAC46441.l| (AF009224) LysR-type

SEQ ID n° 7899 PL-507.1 2374699 to 13° transcriptional activator [Acinetobacter sp .

2375610 ADP1] SEQ ID n~3321

Contig9 from gb|AAF05542.l|AF188483_l (AF188483) toxin A

SEQ ID n° 7900 PL-508.1 2375984 to 68° [Photorhabdus luminescens]

2383360 SEQ ID n~3322

Contig9 from gb|AAC38630.l| (AF047028) insecticidal toxin

SEQ ID n° 7901 PL-509.1 2383553 to 61° complex protein TccC [Photorhabdus

2386369 luminescens] SEQ ID n~3323

Contig9 from gb|AAG58047.l|AE005522_5 (AE005522) partial

SΞQ ID n° 7902 PL-510.1 2386532 to 18% putative transcriptional regulator LYSR-type

2387446 [Ξscherichia coli 0157 :H7] SEQ ID n~3325

Contig9 from gb|AAF05542.l|AF188483_l (AF188483) toxin A

SEQ ID n° 7903 PL-511.1 2388140 to 91% [Photorhabdus luminescens]

2395717 SEQ ID n~3326

Contig9 from gb|AAC38625.l| (AF046867) insecticidal toxin

SEQ ID n° 7904 PL-512.1 2395770 to 73% complex protein TcaC [Photorhabdus

2400200 luminescens] SEQ ID n~3327

Contig9 from gb|AAC38630.l| (AF047028) insecticidal toxin

SEQ ID n° 7905 PL-513.1 2400781 to 60° complex protein TccC [Photorhabdus

2403528 luminescens] SEQ ID n~3328

Contig9 from

SΞQ ID n° 7906 PL-7174.1 2403675 to No Hits found

2403779 #N/A pir| |G82452 conserved hypothetical protein

VCA0482 [imported] - Vibrio cholerae

Contig9 from

(group 01 strain N16961) g | AAF96227.1 | SEQ ID n° 7907 PL-5865.1 2403991 to 54°

(AE004370) conserved hypothetical protein

2404287

[Vibrio cholerae] gb| AAF96386.1 | (AE004380) conserved hypothetical protein [Vibrio cholerae] #N/A

TABLEAU II

pir| |F82452 conserved hypothetical protein

VCA0481 VCA0318 [imported] - Vibrio

Contig9 from cholerae (group 01 strain N16961) SEQ ID n° 7908 PL-3550.1 2404343 to 603 gb|AAF96226.l| (AE004370) conserved hypothetical

2404777 protein [Vibrio cholerae] gb | AAF96385.1 |

(AΞ004380) conserved hypothetical protein

[Vibrio cholerae] SEQ ID n~2751 sp | 052402 | ALF_EDWIC FRUCTOSE-BISPHOSPHATE

Contig9 from

ALDOLASE gb |AAB92572.1 | (AF037440) fructose 1,6-

SEQ ID n° 7909 PL-514.1 2404845 to m 90° bisphosphate aldolase [Edwardsiella

2405921 ictaluri] SEQ ID n~3329 sp | P11665 ] PGK_ΞC0LI PHOSPHOGLYCΞRATE KINASE pir| ]TVΞCG phosphoglycerate kinase (EC 2.7.2.3)

Escherichia coli emb|CAA32604. l| (X14436)

Contig9 from phosphoglycerate kinase (AA 1-387) [Ξscherichia

SEQ ID n° 7910 PL-515.1 2405984 to m 923 coli] gb|AAA69093.l[ (U28377) phosphoglycerate

2407147 kinase [Ξscherichia coli] gb( AAC75963.l|

(AEO 00376) phosphoglycerate kinase [Ξscherichia coli K12] SΞQ ID n~3330 sp|P11603 |E4PD_ΞCOLI D-ERYTHROSΞ 4-PHOSPHATΞ

DEHYDROGENASE (Ξ4PDH) pir | | DΞΞCGB glyceraldehyde-3 -phosphate dehydrogenase (EC

1.2.1.12) B - Ξscherichia coli emb|CAA32603.l| (X14436) glyceraldehyde 3- phosphate dehydrogenase (AA 1-339)

Contig9 from

[Ξscherichia coli] gb| AAA69094.1 | (U28377)

SΞQ ID n° 7911 PL-516.1 2407231 to m 86% glyceraldehyde 3 -phosphate dehydrogenase

2408250

[Escherichia coli] gb|AAC75964.l|

(AE000376) D-erythrose 4-phosphate dehydrogenase

[Escherichia coli K12] gb[AAG58053.l|AE005523_2 (AΞ005523) D-erythrose

4-phosphate dehydrogenase [Escherichia coli

0157 :H7] SEQ ID n~3331

TABLBAU II

pir||C83622 probable short-chain dehydrogenase

PAO182 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 7912 PL-5866.1 2408745 to m 68^e gb(AAG03572.l|AΞ004456_3 (AE004456) probable

2408948 short-chain dehydrogenase [Pseudomonas aeruginosa] #N/A pir| |B83228 probable MFS transporter PA3336

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 7913 PL-5868.1 2408971 to 383 (strain PAOl) gb| AAG06724.l| AΞ004756_2

2409138 (AE004756) probable MFS transporter [Pseudomonas aeruginosa] #N/A

Contig9 from SEQ ID n° 7914 PL-5869.1 2409126 to m No Hits found

2409455 #N/A Contig9 from SEQ ID n° 7915 PL-3552.1 2409497 to m No Hits found

2409862 SΞQ ID n~2752 Contig9 from emb|CAB64355.l| (AJ243941) eugenol hydroxylase SEQ ID n° 7916 PL-517.1 2409900 to m 45% flavoprotein subunit [Pseudomonas

2410496 sp.] SEQ ID n~3332 Contig9 from SEQ ID n° 7917 PL-5872.1 2410612 to p No Hits found

2410773 #N/A pir| |D83279 probable transcriptional regulator

PA2931 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 7918 PL-518.1 2410869 to 59% gb|AAG06319.l|AΞ004719_5 (AΞ004719) probable

2411462 transcriptional regulator [Pseudomonas aeruginosa] SΞQ ID n~3333 sp|Q10846|YKll_MYCTU HYPOTHΞTICAL 15.7 KDA

PROTΞIN RV2011C PRΞCURSOR pir( |A70760

Contig9 from hypothetical protein Rv2011c - Mycobacterium SEQ ID n° 7919 PL-3553.1 2411760 to p 38% tuberculosis (strain H37RV)

2412233 emb|CAA98404.l| (Z74025) hypothetical protein

Rv2011c [Mycobacterium tuberculosis] SΞQ ID n~2753

TABLEAU II

Contig9 from SEQ ID n° 7920 PL-5873.1 2412614 to p No Hits found

2412985 #N/A Contig9 from SEQ ID n° 7921 PL-5874.1 2412973 to No Hits found

2413110 #N/A Contig9 from gb|AAG58065.l|AE005524_l (AE005524) SEQ ID n° 7922 PL-519.1 2413091 to m 903 transketolase 1 isozyme [Ξscherichia coli

2415085 0157 :H7] SEQ ID n~3334 pir( |C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 7923 PL-520.1 2415700 to 32% gb|AAG04736.l|AE004564_5 (AE004564) probable

2416482 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~3336

Contig9 from gb|AAF22961.l|AF157489_l (AF157489) Pin SEQ ID n° 7924 PL-5875.1 2417055 to 443 [Photorhabdus luminescens]

2417321 #N/A sp(P14566[DP3E_SALTY DNA POLYMERASE III, EPSILON

Contig9 from CHAIN gb|AAA86422.l[ (U44090) dnaQ [Salmonella SEQ ID n° 7925 PL-521.1 2417768 to m 843 typhimurium] gb[AAC44792.l| (U77465) DNA

2418514 polymerase III epsilon chain [Salmonella typhimurium] SEQ ID n~3337

Contig9 from pdb[lRBR| Ribonuclease H (E.C.3.1.26.4) Mutant SEQ ID n° 7926 PL-3554.1 2418572 to 76% With His 62 Replaced By Pro (H62p)

2419042 SEQ ID n~2754 Contig9 from gb|AAG54509.l(AE005196 7 (AE005196) orf, SEQ ID n° 7927 PL-522.1 2419043 to m 723 hypothetical protein [Escherichia coli 0157 :H7]

2419756 SEQ ID n~333E

TABLEAU II

sp|Q47677|GL02_ECOLI PROBABLE

HYDROXYACYLGLUTATHIONE HYDROLASE (GLYOXALASE II)

(GLX II) pir| [F64745 probable hydroxyacylglutathione hydrolase (EC 3.1.2.6) gloB - Ξscherichia coli

Contig9 from gb(AAB08634.l| (U70214) hypothetical protein

SΞQ ID n° 7928 PL-523.1 2419801 to 703 [Escherichia coli] gb|AAC73317.l| (AΞ000130)

2420553 probable hydroxyacylglutathione hydrolase

[Escherichia coli K12] dbj |BAA77883.l| (D83536) Hypothetical protein 1

[Escherichia coli] gb[AAG54508.l[AE005196_6

(AΞ005196) probable hydroxyacylglutathione hydrolase [Escherichia coli 0157 :H7] SEQ ID n~3339

Contig9 from gb|AAG54507.l|AE005196_5 (AE005196) SΞQ ID n° 7929 PL-524.1 2420625 to 71% transcriptional regulator for nitrite reductase

2421986 (cytochrome c552) [Escherichia coli 0157:H7] SΞQ ID n~3340 Contig9 from SΞQ ID n° 7930 PL-5877.1 2422484 to m No Hits found

2422669 #N/A

Contig9 from dbj |BAA97424.l| (AB025638) l-aminocyclopropane-1-

SEQ ID n° 7931 PL-525.1 2422725 to 17% carboxylate oxidase [Arabidopsis

2423570 thaliana] SΞQ ID n~33 1

Contig9 from dbj |BAB05758.l| (AP001514) BH2039-unknown

SEQ ID n° 7932 PL-526.1 2423778 to 383 conserved protein in others [Bacillus

2424959 halodurans] SEQ ID n~3342 sp|P58157|KTH2_SULS0 PROBABLE THYMIDYLATΞ KINASE

Contig9 from 2 (DTMP KINASE 2) gb | AAK41441.1 | (AE006735) SEQ ID n° 7933 PL-3555.2 2425009 to 31% Thymidylate kinase (tmK-2) [Sulfolobus

2425545 solfataricus] #N/A pir||S77024 hypothetical protein S110785 -

Contig9 from Synechocystis sp. (strain PCC 6803) SEQ ID n° 7934 PL-527.2 2425673 to 273 dbj |BAA10716.l| (D64005) hypothetical protein

2426806

[Synechocystis sp . ] #N/A

TABLΞAU II

sp|Q57573|Y109_MΞTJA HYPOTHΞTICAL PROTEIN MJ0109 pir| |E64313 hypothetical protein MJ0109 -

Methanococcus jannaschii pdb(lDK4(A Chain A,

Contig9 from Crystal Structure Of MJ0109 Gène Product SEQ ID n° 7935 PL-528.1 2426809 to 40% Inositol Monophosphatase pdb(lDK4|B

2427654 Chain B, Crystal Structure Of MJ0109 Gène

Product Inositol Monophosphatase gb|AAB98091.l| (U67468) extragenic suppressor

(suhB) [Methanococcus jannaschii] SBQ ID n~3344

Contig9 from SEQ ID n° 7936 PL-529.1 2427651 to m No Hits found

2428685 SΞQ ID n~3345 Contig9 from SEQ ID n° 7937 PL-530.1 2428691 to m No Hits found

2429734 SEQ ID n-3347 Contig9 from SΞQ ID n° 7938 PL-5879.1 2

pir( [T49209 leucoanthocyanidin dioxygenase-like protein - Arabidopsis thaliana emb|CAB87851.l|

Contig9 from (AL163832) leucoanthocyanidin dioxygenase-like SΞQ ID n° 7939 PL-531.1 2431493 to 223 protein [Arabidopsis thaliana]

2432407 emb|CAC19787.l| (AJ298225) putative leucoanthocyanidin dioxygenase [Arabidopsis thaliana] SΞQ ID n~3348

Contig9 from SEQ ID n° 7940 PL-3556.1 2432530 to m No Hits found

2432874 SΞQ ID n~2756 Contig9 from SEQ ID n° 7941 PL-5881.1 2432852 to m No Hits found

2433214 #N/A pir| |E82951 probable MFS transporter PA5548

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 7942 PL-532.1 2433592 to 71% (Strain PAOl) gb|AAG08933.l| AΞ004967_4

2434764 (AΞ004967) probable MFS transporter [Pseudomonas aeruginosa] SEQ ID n~3349

TABLΞ U II

Contig9 from gb[AAK03251.l| (AE006157) unknown [Pasteurella SEQ ID n° 7943 PL-533.2 2434886 to m 713 multocida]

2436271 SEQ ID n~S350 Contig9 from SEQ ID n° 7944 PL-5885.1 2436246 to No Hits found

2436398 #N/A pir||C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 7945 PL-534.1 2437427 to 293 gb|AAG04736.l|AE004564_5 (AE004564) probable

2438149 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~3351 pir||C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl)

SEQ ID n° 7946 PL-535.1 2438310 to 303 gb|AAG04736.l|AE004564_5 (AE004564) probable

2439032 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~3352 pir||C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl)

SEQ ID n° 7947 PL-536.1 2439194 to 333 gb|AAG04736.l|AE004564_5 (AE004564) probable

2439916 transcriptional regulator [Pseudomonas aeruginosa] SΞQ ID n~3353 pir||C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl)

SEQ ID n° 7948 PL-537.1 2440202 to 303 gb|AAG04736.l|AE004564_5 (AE004564) probable

2440924 transcriptional regulator [Pseudomonas aeruginosa] SΞQ ID n~3354 pir[[C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl)

SEQ ID n° 7949 PL-538.1 2441242 to 333 gb|AAG04736.l|AΞ004564_5 (AΞ004564) probable

2441964 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~3355

TABLEAU II

pir| |C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 7950 PL-539.1 2442265 to 333 gb|AAG04736.l|AE004564_5 (AΞ004564) probable

2442987 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~3356 pir| |C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SΞQ ID n° 7951 PL-540.1 2443309 to 343 gb|AAG04736.l|AE004564_5 (AΞ004564) probable

2444031 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~3358 pir| |C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 7952 PL-541.1 2443973 to 273 gb|AAG04736.l|AE004564_5 (AE004564) probable

2444914 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~3359

Contig9 from gb|AAF22961.l[AF157489_l (AF157489) Pin

SΞQ ID n° 7953 PL-5887.1 2445235 to m 873 [Photorhabdus luminescens]

2445447 #N/A

Contig9 from gb|AAK06333.l|AE006452_6 (AE006452) transporter

SΞQ ID n° 7954 PL-542.1 2446007 to m 393 [Lactococcus lactis subsp. lactis]

2447200 SEQ ID n-S360 pir| |A71652 iron-sulfur cofactor synthesis

Contig9 from protein RP486 - Rickettsia prowazekii

SΞQ ID n° 7955 PL-543.1 2447223 to m 653 emb|CAA14939.l| (AJ235272) NIFS PROTEIN HOMOLOG

2448404

(spll) [Rickettsia prowazekii] SEQ ID n~3361

Contig9 from

SEQ ID n° 7956 PL-544.1 2448595 to m No Hits found

2449308 SEQ ID n~3362

Contig9 from gb|AAK03 55.l| (AE006225) Ξno [Pasteurella

SEQ ID n° 7957 PL-546.1 2449985 to 94% multocida]

2451286 SΞQ ID n~3364

TABLΞAU II

s | PO8398 | PYRG_ECOLI CTP SYNTHASE (UTP- -AMMONIA

LIGASE) (CTP SYNTHETASE) pir) | SYECTP CTP synthase (EC 6.3.4.2) [validated] - Escherichia

Contig9 from coli gb|AAA69290.l| (U29580) CTP synthetase

SEQ ID n° 7958 PL-547.1 2451360 to 943

[Escherichia coli] gb | AAC7582 .1 [ (AE000361)

2452997

CTP synthetase [Escherichia coli K12] gb|AAG57893.1 | Ξ005506_1 (AΞ005506) CTP synthetase [Escherichia coli 0157 :H7] SEQ ID n~3365 sp|P33646|MAZG_ECOLI MAZG PROTEIN pir| |A65060 azG protein - Escherichia coli (strain K-12)

Contig9 from gb]AAA69291.l| (U29580) CG Site No. 33299

SEQ ID n° 7959 PL-548.1 2453219 to 783 [Escherichia coli] gb | AAC75823.1 | (AE000362)

2453998 orf, hypothetical protein [Ξscherichia coli K12] gb|AAG57894.l|AΞ005506_2 (AE005506) orf, hypothetical protein [Ξscherichia coli 0157 :H7] SΞQ ID n~S366 sp|P11585|RΞLA_ECOLI GTP PYROPHOSPHOKINASE

(ATP : GTP 3 ' -PYROPHOSPHOTRANSFERASΞ) (PPGPP

SYNTHETASE I) ((P) PPGPP SYNTHΞTASE) pir||κiECG

GTP pyrophosphokinase (ΞC 2.7.6.5) - Escherichia coli gb]AAA69294.l| (U29580) GTP pyrophosphokinase [Escherichia coli]

Contig9 from gb|AAC75826.l| (AEO 00362) (p)ppGpp synthetase I

SEQ ID n° 7960 PL-549.1 2454066 to 89%

(GTP pyrophosphokinase) ; régulation

2456297 of RNA synthesis,- stringent factor

[Escherichia coli K12] gb| AG57897.1 |AE005506_5

(AΞ005506) (p)ppGpp synthetase I (GTP pyrophosphokinase) ,- régulation of RNA synthesis; stringent factor

[Escherichia coli 0157 :H7] SEQ ID n~3367 sp(P55135[YGCA_ECOLI HYPOTHΞTICAL RNA

MΞTHYLTRANSFERASE IN RELA-BARA INTERGENIC REGION

Contig9 from pir| |E65060 ygcA protein - Escherichia coli

SEQ ID n° 7961 PL-550.1 2456339 to 74= (strain K-12) gb|AAA69295.l| (U29580) alternate

2457655 gène name ygcA; ORF_f433 [Escherichia coli] gb|AAC75827.l| (AEO00362) putative enzyme

[Escherichia coli K12] SEQ ID n~3369

TABLΞAU II

Contig9 from gb|AAG57899.l|AE005506 7 (AE005506) sensor-

SΞQ ID n° 7962 PL-551.1 2457709 to 623 regulator, activâtes OmpR by phophorylation

2460036 [Ξscherichia coli 0157 :H7] SΞQ ID n~3370 sp | P15723 | DGTP_ECOLI DEOXYGUANOSINΞTRIPHOSPHATΞ

TRI HOSPHOHYDROLASE (DGTPASΞ) pir | |A35993 dGTPase (ΞC 3.1.5.1) - Escherichia coli gb|AAA23679.l| (M31772) dGTP triphosphohydrolase

[Escherichia coli] dbj |BAA05607 ,l| (D26562)

Contig9 from

' deoxyguanosine triphosphate

SΞQ ID n° 7963 PL-552.1 2460051 to m 73^! triphosphohydrolase ' [Ξscherichia 2461577 coli] gb|AAB08590. l| (U70214) deoxyguanosine triphosphate [Escherichia coli] gb[ AAC73271.1 |

(AE000125) deoxyguanosine triphosphate triphosphohydrolase [Escherichia coli

K12] SEQ ID n~3371 sp|P24247|PFS_ΞCOLI MTA/SAH NUCLΞOSIDASΞ (P46)

[INCLUDΞS : 5 ' -MΞTHYLTHIOADΞNOSINΞ

NUCLΞOSIDASΞ ; S-ADENOSYLHOMOCYSTΞINΞ

NUCLEOSIDASE ] pir||S45227 pfs protein -

Escherichia coli dbj |BAA05606.l| (D26562) 'ORF'

Contig9 from [Escherichia coli] gb| AAB08589.1 | (U70214)

SEQ ID n° 7964 PL-553.1 2461705 to similar to purine nucleoside phosphorylase

2462406 (deoD) [Escherichia coli] gb|AAC73270.l| (AE000125) orf, hypothetical protein [Escherichia coli K12] gb|AAC3829l.l|

(U24438) MTA/SAH nucleosidase [Ξscherichia coli] gb|AAG54463.l|AΞ005192_5 (AE005192) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~3372 sp|P37028|YADT_ECOLI HYPOTHΞTICAL 29.4 KD

PROTEIN IN HEML-PFS INTΞRGENIC RΞGION

Contig9 from PRΞCURSOR pir|]F64739 yadT protein -

SEQ ID n° 7965 PL-554.1 2462612 to p 603 Ξscherichia coli gb] AAB08588.l| (U70214)

2463439 hypothetical [Ξscherichia coli] gb| AC73269.l|

(AE000125) orf, hypothetical protein

[Escherichia coli K12] SEQ ID n~3373

TABLEAU II

S I P37026 | ADR_ECOLI HYPOTHΞTICAL 12.1 KD

PROTEIN IN HEML-PFS INTΞRGΞNIC RΞGION pir| |S45225 yadR protein - Ξscherichia coli dbj [BAA05604.l| (D26562) 'ORF' [Ξscherichia

Contig9 from coli] gb|AAB08586.l| (U70214) hypothetical SEQ ID n° 7966 PL-5891.1 2463528 to m 813 protein [Ξscherichia coli] gb|AAC73267.l|

2463875

(AΞ000125) orf, hypothetical protein

[Ξscherichia coli K12] gb|AAG54460.l|AE005192_2

(AE005192) orf, hypothetical protein

[Ξscherichia coli 0157 :H7] #N/A pir| |B82212 hypothetical protein VC1330

Contig9 from

[imported] - Vibrio cholerae (group 01 SΞQ ID n° 7967 PL-555.1 2464181 to 583 strain N16961) gb| AAF94488.1 | (AE004213)

2464966 hypothetical protein [Vibrio cholerae] SΞQ ID n~3374

Contig9 from gb|AAG54458.l|AE005191_9 (AΞ005191) glutamate-1- SΞQ ID n° 7968 PL-556.1 2465017 to 90% semialdehyde aminotransferase (aminomutase)

2466300 [Escherichia coli 0157 :H7] SΞQ ID n-3375- gb|AAC70896.l| (AF006830) virulence plasmid protein [Actinobacillus

Contig9 from actinomycetemcomitans] dbj ] BAA35114.1 | SEQ ID n° 7969 PL-5893.1 2466342 to m 373 (AB017807) ORF1 [Actinobacillus

2466605 actinomycetemcomitans] gb | AAG09111.1 |

(AF102554) unknown [Actinobacillus actinomycetemcomitans] #N/A ref |NP_04694 .l| gp48 [Bacteriophage N15]

Contig9 from pir| |T13135 protein gp48 - phage N15 SΞQ ID n° 7970 PL-5894.1 2466917 to 693 gb|AAC19087.l| (AF064539) gp48 [Bacteriophage

2467201

N15] #N/A

Contig9 from emb | CACO1604. l| (AJ269505) peptide synthetase

SEQ ID n° 7971 PL-557.1 2467342 to m 413 [Anabaena sp. 90]

2473371 SΞQ ID n~3376

Contig9 from emb [CACO160 .l| (AJ269505) peptide synthetase

SEQ ID n° 7972 PL-558.1 2473368 to 533 [Anabaena sp. 90]

2478101 SΞQ ID n~3377

TABLB U II

Contig9 from gb(AAF17281.l| (AF204805) NOSD [NOStOC S . SΞQ ID n° 7973 PL-559.1 2478098 to m 563 GSV224]

2481604 SEQ ID n~3378 Contig9 from SEQ ID n° 7974 PL-7053.1 2482168 to p No Hits found

2482281 #N/A Contig9 from gb|AAG31049.l|AF264948_ll (AF264948) SΞQ ID n° 7975 PL-560.1 2482397 to m 48% hypothetical protein [Ξrwinia amylovora]

2483713 SΞQ ID n~3380 Contig9 from SEQ ID n° 7976 PL-5895.1 2483707 to m No Hits found

2484060 #N/A Contig9 from SEQ ID n° 7977 PL-5896.1 2484188 to m No Hits found

2484496 #N/A pir| |B56394 pyocin S3 immunity protein -

Contig9 from Pseudomonas aeruginosa (strain P12) SΞQ ID n° 7978 PL-3558.1 2484602 to m 50% emb|CAA54959.l| (X77996) immunity protein of

2485030 pyocin S3 [Pseudomonas aeruginosa] SΞQ ID n~2758 sp|P13479|lMM9_ΞCOLI COLICIN Ξ9 IMMUNITY PROTEIN (IMME9) (MICROCIN E9 IMMUNITY PROTEIN) pdb|lEMV|A Chain A, Crystal Structure Of Colicin

Contig9 from Ξ9 Dnase Domain With Its Cognate SEQ ID n° 7979 PL-5897.1 2485292 to m 673 Immunity Protein Im9 (1.7 Angstroms) pdb|lIMQ|

2485549 Colicin E9 Immunity Protein Im9, Nmr, Minimized

Average Structure emb | CAA33863.1 |

(X15858) Ξ9 immunity protein (86 AA)

[Enterobacteriaceae] #N/A pir| |B56394 pyocin S3 immunity protein -

Contig9 from

Pseudomonas aeruginosa (strain P12) SEQ ID n° 7980 PL-3559.1 2485611 to m 26% emb|CAA54959.l| (X77996) immunity protein of

2486159 pyocin S3 [Pseudomonas aeruginosa] SΞQ ID n~2759 pir| |B56394 pyocin S3 immunity protein -

Contig9 from

Pseudomonas aeruginosa (strain P12) SΞQ ID n° 7981 PL-3560.1 2486143 to m 48% emb|CAA54959.l] (X77996) immunity protein of

2486610 pyocin S3 [Pseudomonas aeruginosa] SEQ ID n~2761

TABLΞAU II

Contig9 from pir[ [A56394 pyocin S3 - Pseudomonas aeruginosa SΞQ ID n^» 7982 PL-5898.1 2486623 to m 4f (strain P12) emb|CAA54958. l| (X77996) killer

2486766 protein of pyocin S3 [Pseudomonas aeruginosa] #N/A sp|P04482|lMM2_ΞCOLI COLICIN E2 IMMUNITY PROTEIN

(IMME2) (MICROCIN E2 IMMUNITY PROTEIN) pir| | IMECE2 colicin E2 immunity protein -

Contig9 from

Ξscherichia coli plasmids emb|CAA26146.l[ SEQ ID n° 7983 PL-5899.1 2486896 to m 713

(X022 7) immE2 polypeptide [Escherichia coli]

2487147 gb|AAA23069.l( (M29885) colicin immunity protein

(ceiB) [Plasmid ColE2] emb|CAA25610.l| (X01163)

Ξ2 immunity protein (aa 1-86) [Ξscherichia coli] #N/A

Contig9 from ref |NP_068716.l| klebicin B [Klebsiella SEQ ID n° 7984 PL-3561.1 2487155 to m 68% pneumoniae] gb | AAD39262.2 | (AF156893) klebicin

2487604 B [Klebsiella pneumoniae] SEQ ID n~2762 pir| |B56394 pyocin S3 immunity protein -

Contig9 from

Pseudomonas aeruginosa (strain P12) SEQ ID n° 7985 PL-3562.1 2487701 to 583 emb|CAA54959.l| (X77996) immunity protein of

2488153 pyocin Ξ3 [Pseudomonas aeruginosa] SEQ ID n~2763 pir| |B56394 pyocin S3 immunity protein -

Contig9 from

Pseudomonas aeruginosa (strain P12) SEQ ID n° 7986 PL-3563.2 2488235 to 52% emb|CAA54959.l| (X77996) immunity protein of

2488687 pyocin S3 [Pseudomonas aeruginosa] #N/A

Contig9 from pir| |A56394 pyocin S3 - Pseudomonas aeruginosa SEQ ID n° 7987 PL-561.2 2488687 to 273 (strain P12) emb| CAA54958. l| (X77996) killer

2490360 protein of pyocin S3 [Pseudomonas aeruginosa] #N/A Contig9 from gb|AAG54453.l|AE005191_4 (AΞ005191) SEQ ID n° 7988 PL-562.1 2490845 to m 83' peptidoglycan synthetase; penicillin-binding

2493301 protein 1B [Escherichia coli 0157 :H7] SEQ ID n~3382 Contig9 from gb[AAG54452.1 (AE005191_3 (AΞ005191) helicase, SEQ ID n° 7989 PL-563.1 2493395 to m 74% ATP-dependent [Escherichia coli 0157 :H7]

2495884 SEQ ID n~3383 Contig9 from gb|AAD38234.l| (U17224) CarF [Pectobacterium SEQ ID n° 7990 PL-564.1 2496425 to 613 carotovorum]

2497258 SEQ ID n~3384

TABLEAU II

Contig9 from gb|AAD38235.l| (U17224) CarG [Pectobacterium SEQ ID n° 7991 PL-3564.1 2497248 to 553 carotovorum]

2497784 SΞQ ID n~2765 Contig9 from gb|AAD38236.l| (U17224) CarH [Pectobacterium SEQ ID n° 7992 PL-3565.1 2497781 to P 533 carotovorum]

2498326 SΞQ ID n~2766 Contig9 from gb]AAG53986.l|AF327444_2 (AF327444) putative SEQ ID n° 7993 PL-5900.1 2498390 to 373 transposase B [Ξrwinia herbicola]

2498659 #N/A pir| |F82304 sugar fermentation stimulation

Contig9 from protein VC0597 [imported] - Vibrio SΞQ ID n° 7994 PL-1579.2 2498792 to 703 cholerae (group 01 strain N16961)

2499538 gb|AAF93764.l| (AE004144) sugar fermentation stimulation protein [Vibrio cholerae] #N/A

Contig9 from SΞQ ID n° 7995 PL-7169.1 2499552 to m No Hits found

2499653 #N/A Contig9 from sp|Q9ZIW3|DKSA_SALTY DNAK SUPPRESSOR PROTΞIN SEQ ID n° 7996 PL-3566.1 2499734 to 933 gb|AAD01437.l| (AF010249) DksA homolog

2500189 [Salmonella typhimurium] SΞQ ID n~2767 sp | P27305 [ ADB_ECOLI HYPOTHETICAL 34.9 KD

PROTEIN IN PCNB-DKSA INTERGENIC REGION

Contig9 from pir( |H64737 glutamate--tRNA ligase homolog yadB SΞQ ID n° 7997 PL-1580.1 2500252 to 68%

Escherichia coli (strain K-12)

2501202 gb|AAC73255.l| (AΞ000123) putative tRNA synthetase [Ξscherichia coli K12] SΞQ ID n~679

Contig9 from SΞQ ID n° 7998 PL-1581.1 C ΞΞQ ID n° 7999 PL-3567.1

2503316 [Escherichia coli Ol57:H7] SEQ ID n~2768

TABLEAU II

pir| |A47152 3-methyl-2-oxobutanoate

Contig9 from hydroxymethyltransferase (ΞC 2.1.2.11) - SEQ ID n° 8000 PL-1582.1 2503387 to p 823 Escherichia coli emb|CAA46505.l| (X65538) 3-

2504178 methyl-2 -oxobutanoate hydroxymethyltransferase

[Ξscherichia coli] SEQ ID n~S81 sp|P31663| PANC_ECOLI PANTOATE- -BETA-ALANINE

LIGASE (PANTOTHENATE S NTHΞTASΞ) (PANTOATΞ

Contig9 from ACTIVATING ΞNZYMΞ) pir| (Ξ64736 pantoate--beta-

SEQ ID n° 8001 PL-1583.1 2504205 to 833 alanine ligase (ΞC 6.3.2.1) - Escherichia coli

2505059 gb|AAA24272. l| (L17086) pantothenate synthetase

[Ξscherichia coli] gb | AAC73244.l| (AE000122) pantothenate synthetase [Escherichia coli K12] SEQ ID n~082 sp|P3166 |PAND_ECOLI ASPARTATE 1-DECARBOXYLASE

PRECURSOR (ASPARTATE ALPHA-DECARBOXYLASE) pir| |C64736 aspartate 1-decarboxylase (EC

4.1.1.11) [validated] - Escherichia

Contig9 from coli gb|AAA24274.ι| (L17086) aspartate-l- SEQ ID n° 8002 PL-5902.1 2505127 to 803 decarboxylase [Ξscherichia coli] gb| AAC73242. l|

2505507

(AE000122) aspartate 1-decarboxylase

[Escherichia coli K12] gb[AAG54435.l(AE005l89_8

(AE005189) aspartate 1-decarboxylase

[Escherichia coli 0157 :H7] #N/A sp | P36880 | YADH_ECOLI HYPOTHETICAL 28.5 KD

PROTEIN IN HPT-PAND INTERGΞNIC REGION pir| |H64735 probable ABC-2-type transport

Contig9 from protein yadH - Escherichia coli gb[AAC73239.l[ SEQ ID n° 8003 PL-1584.1 2505586 to 88%

(AΞ000122) orf, hypothetical protein

2506356

[Ξscherichia coli K12] gb|AAG54432.1 [AE005189_5

(AE005189) orf, hypothetical protein

[Escherichia coli 0157 :H7] SEQ ID n-683

TABLΞAU II

sp|P36879|YADG_ΞCOLI HYPOTHETICAL ABC

TRANSPORTΞR ATP-BINDING PROTΞIN YADG pir| |S45204 probable ABC-type transport protein

Contig9 from yagD - Ξscherichia coli dbj |BAA05583.l| SEQ ID n° 8004 PL-1585.1 2506368 to 88%

(D26562) 'ORF' [Escherichia coli]

2507279 gb|AAC73238.l| (AΞ000122) putative ATP-binding component of a transport System

[Ξscherichia coli K12] SΞQ ID n~β84 sp|P36857|YADF_ΞCOLI HYPOTHΞTICAL 25.1 KD

PROTΞIN IN HPT-PAND INTERGENIC REGION

Contig9 from pir| |F64735 yadF protein - Escherichia coli SΞQ ID n° 8005 PL-1586.1 2507467 to 843 gb| AAC73237.l| (AE000122) putative carbonic

2508120 anhdrase (ΞC 4.2.1.1) [Ξscherichia coli K12] SEQ ID n~θ85 pir| |H82771 proteic killer suppression protein

Contig9 from XF0721 [imported] - Xylella SEQ ID n° 8006 PL-5903.1 2509640 to 773 fastidiosa (strain 9a5c)

2509921 gb|AAF83531.l|AΞ003914_12 (AΞ003914) proteic killer suppression protein [Xylella fastidiosa] #N/A pir| |G82771 proteic killer active protein XF0720

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 8007 PL-5905.1 2509932 to 66% (strain 9a5c) gb | AAF83530.1 |AΞ003914_11

2510210 (AΞ003914) proteic killer active protein

[Xylella fastidiosa] #N/A sp | 033799 | HPRT_SALTY HYPOXANTHINΞ

Contig9 from PHOSPHORIBOSYLTRANSFΞRASΞ (HPRT) gb | AAC46255. l| SEQ ID n° 8008 PL-3568.1 2510310 to m 893 (AF008931) hypoxanthine

2510861 phosphoribosyltransferase [Salmonella typhimurium] SΞQ ID n~2769

Contig9 from SEQ ID n° 8009 PL-3569.1 2511181 to m No Hits found

2511735 SΞQ ID n~2770 Contig9 from SEQ ID n° 8010 PL-3570.1 2511875 to m 583 emb|CAC05783.l| (AL391753) ORF47,

2512375 SΞQ ID n~2772

TABLΞAU II

Contig9 from SΞQ ID n° 8011 PL-5906.1 2

2.4.2.8) - Ξscherichia coli

Contig9 from dbj |BAA05581.1| (D26562) 'ORF' [Ξscherichia SEQ ID n° 8012 PL-3571.1 2512879 to m 89% coli] gb|AAC73236.l| (AE000122) hypoxanthine

2513424 phosphoribosyltransferase [Escherichia coli

K12] gb|AAG54429.l|AΞ005189_2 (AΞ005189) hypoxanthine phosphoribosyltransferase

[Escherichia coli 0157 :H7] SEQ ID n~2773

Contig9 from gb|AAF22961.l|AF157489_l (AF157489) Pin SΞQ ID n° 8013 PL-5907.1 2513794 to m 43% [Photorhabdus luminescens]

2514057 #N/A Contig9 from SEQ ID n° 8014 PL-3572.1 2515163 to No Hits found

2515627 SΞQ ID n~2774 sp|P05790 |FBOH_BOMMO FIBROIN HEAVY CHAIN

Contig9 from PRBCURSOR (FIB-H) (H-FIBROIN) SEQ ID n° 8015 PL-5910.1 2515641 to p 413 gb|AAF76983.l|AF226688_l (AF226688) fibroin

2516015 heavy chain Fib-H [Bombyx mori] #N/A pir| |C81043 hypothetical protein NMB1786

Contig9 from [imported] - Neisseria meningitidis SEQ ID n° 8016 PL-1587.1 2516175 to p 553 (group B strain MD58) gb | AF42125. l| (AE002528)

2517341 hypothetical protein [Neisseria meningitidis

MC58] SΞQ ID n~686 pir| |H83126 probable secretion protein PA4142

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 8017 PL-5911.1 2517331 to p 53% (strain PAOl) gb| AG07529.l| AEO 04831_1

2517759 (AEO 04831) probable secretion protein

[Pseudomonas aeruginosa] #N/A

TABLEAU II

pir||C81839 probable transposase for IS1655

NMA1481 [imported] - Neisseria meningitidis (group B strain MD58, group A

Contig9 from strain Z2491) emb |CAB84714.1 | (AL162756) SΞQ ID n° 8018 PL-1588.1 2517830 to 603 putative transposase for IS1655 [Neisseria

2518798 meningitidis Z2491] emb| CAB84719.l|

(AL162756) putative transposase for IS1655

[Neisseria meningitidis Z2491] SΞQ ID n~β87

Contig9 from gb|AAF61809.l| (AF129811) unknown [Moraxella

SΞQ ID n° 8019 PL-1589.1 2518780 to 53% catarrhalis]

2519691 SEQ ID n~688

Contig9 from gb|AAF61810.l| (AF129811) unknown [Moraxella

SΞQ ID n° 8020 PL-1590.1 2519697 to 693 catarrhalis]

2521790 SEQ ID n-690 pirj |E64781 hypothetical protein b0502 -

Escherichia coli gb| AAB40255.1 | (U82664)

Contig9 from similar to A. pleuropneumoniae orfl [Escherichia SΞQ ID n° 8021 PL-3573.1 2521980 to 473 coli] gb|AAC73604.l| (AE000156) orf,

2522360 hypothetical protein [Ξscherichia coli K12] gb|AAG54858.l|AΞ005231_5 (AΞ005231) orf, hypothetical protein [Ξscherichia coli 0157 :H7] SΞQ ID n~2775

Contig9 from gb|AAG55933.l|AΞ005327_3 (AE005327) putative

SEQ ID n° 8022 PL-5914.1 2522380 to m 643 integrase of prophage CP-933C [Escherichia coli

2522613 0157.-H7] #N/A

Contig9 from

SΞQ ID n° 8023 PL-5915.1 2522632 to m No Hits found

2522826 #N/A

Contig9 from emb | CAB60145 . l | (Y15953 ) ClpX protein

SEQ ID n° 8024 PL-3574.2 2523372 to 19% [Oenococcus oeni]

2523857 #N/A

Contig9 from

SEQ ID n° 8025 PL-1591.1 2524048 to m No Hits found

2524821 SΞQ ID n~S91

Contig9 from

SEQ ID n° 8026 PL-5917.1 2524828 to m No Hits found

2525052 #N/A

TABLEAU II

sp|P36649|YACK_ECOLI PROBABLE BLUΞ-COPPER

Contig9 from PROTEIN YACK PRECURSOR pir| | C64735 probable SEQ ID n° 8027 PL-1592.1 2525321 to 77% ç pper-binding protein yacK - Escherichia coli

2526865 gb|AAC73234.l| (AE000121) orf , hypothetical protein [Escherichia coli K12] SEQ ID n~β92

_pir||B64735 yacC protein - Escherichia coli

Contig9 from gb|AAC73233.l| (AE000121) orf, hypothetical SEQ ID n° 8028 PL-5918.1 2527192 to 623 protein [Escherichia coli K12]

2527539 gb|AAG54426.l|AΞ005188_7 (AE005188) yacC gène product [Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG54425.l|AE005188_6 (AEO 05188) spermidine SEQ ID n° 8029 PL-1593.1 2527652 to 81? synthase = putrescine aminopropyltransferase

2528521 [Escherichia coli 0157 :H7] SEQ ID n~693 sp ] P09159 | DCAM_ECOLI S-ADΞNOSYLMETHIONINΞ

DECARBOXYLASE PROENZYME (ADOMETDC) pir| | DCECDM adenosylmethionine decarboxylase (EC 4.1.1.50) precursor - Escherichia coli gb|AAA24644.l| (J02804) S-adenosylmethionine

Contig9 from decarboxylase [Escherichia coli] gb | AAC73231.1 | SEQ ID n° 8030 PL-1594.1 2528560 to 913 (AE000121) S-adenosylmethionine decarboxylase

2529354 [Escherichia coli K12] dbj |BAA05576.l[ (D26562) 'adenosylmethionine decarboxylase proenzyme ' [Escherichia coli] gb]AAG54424.l|AE005188_5 (AE005188) S- adenosylmethionine decarboxylase [Escherichia coli 0157 :H7] SEQ ID n~694

Contlg9 from dbj |BAA88679.l| (AB029373) ORF [Thermus SΞQ ID n° 8031 PL-3575.1 2529446 to m 52% thermophilus]

2529985 SΞQ ID n~2777

Contig9 from SEQ ID n° 8032 PL-1595.1 2530073 to m No Hits found

2531992 SΞQ ID n-895 Contig9 from gb|AAC44684.l| (U65015) putative aldolase SEQ ID n° 8033 PL-1596.1 2532017 to m 813 [Vibrio furnissii]

2532877 SEQ ID n~S96

TABLΞAU II

Contig9 from gb[AAG58265.l|AE005542_8 (AΞ005542) putative

SΞQ ID n° 8034 PL-5920.1 2532887 to 663 phosphotransferase system enzyme subunit

2533321 [Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG58265.l|AE005542_7 (AΞ005542) putative

SΞQ ID n° 8035 PL-1597.1 2533344 to m 70% phosphotransferase system enzyme subunit

2534237 [Ξscherichia coli 0157:H7] SΞQ ID n~697

Contig9 from gb|AAC44680.l| (U65015) PTS permease for mannose

SΞQ ID n° 8036 PL-1598.1 2534227 to m 753 subunit IIPMan [Vibrio furnissii]

2535024 SΞQ ID n~698 pir| |A65103 pts system, n-acetylgalactosamine-

^"specific Ilb component 2 -

Escherichia coli (strain K-12) gb| AAA57936.1 [

Contig9 from (U18997) 0RF_ol69 [Ξscherichia coli]

SΞQ ID n° 8037 PL-3576.1 2535035 to 73% gb[AAC76167.l| (AΞ000394) PTS System,

2535517 cytoplasmic, N- c tylgalactosamine-spécifie

IIB component 2 (BIIB-AGA) [Ξscherichia coli

K12] gb]AAF81083.l|AF228498_3 (AF228498) AgaV

[Ξscherichia coli] SΞQ ID n~2778

Contig9 from gb|AAG58268.l|AE005542_10 (AE005542) putative SΞQ ID n° 8038 PL-1599.1 2535483 to m 513 tagatose-6-phosphate aldose/ketose isomerase

2536706 [Escherichia coli 0157 :H7] SΞQ ID n~699 sp|P42903 |AGAZ_ECOLI PUTATIVE TAGATOSE 6-

PHOSPHATE KINASΞ AGAZ pir| |H65102 probable tagatose 6-phosphate kinase agaz (EC 2.7.1.-) -

Contig9 from Escherichia coli (strain K-12) gb| AAA57935.l| SΞQ ID n° 8039 PL-1600.1 2536703 to m 653 (U18997) ORF_o426 [Escherichia coli]

2537998 gb|AAC76l66.l| (AE000394) putative tagatose 6- phosphate kinase 2 [Escherichia coli

K12] gb|AAF81082.l[AF228498_2 (AF228498) KbaZ

[Ξscherichia coli] SΞQ ID n~702

TABLEAU II

sp]P42902|AGAR_ΞCOLI PUTATIVΞ AGA OPERON

TRANSCRIPTIONAL REPRESSOR pir| |G65102 probable transcription repressor of aga operon -

Escherichia coli (strain K-12) gb|AAA57934.l| (U18997) ORF_f269 [Ξscherichia

Contig9 from coli] gb|AAC76165.l| (AE000394) putative DΞOR-

SEQ ID n° 8040 PL-1601.1 2538034 to m 613 type transcriptional regulator of aga

2538807 operon [Ξscherichia coli K12] gb(AAF81081.l|AF228498_l (AF228498) AgaR

[Ξscherichia coli] gb| AG58261.1 | AΞ005542_3

(AΞ005542) putative DΞOR-type transcriptional regulator of aga operon [Escherichia coli 0157 :H7] SEQ ID n~703

Contig9 from emb|CAA63264.l| (X92508) ES-beta-lactamase

SEQ ID n° 8041 PL-1602.1 2539207 to p 693 [Klebsiella pneumoniae]

2540364 SEQ ID n~704

Contig9 from gb|AAD10476.2| (U37262) phospholipase Al

SEQ ID n° 8042 PL-1603.1 2540445 to 20% [Serratia sp. MK1]

2541743 SEQ ID n~705

Contig9 from

SEQ ID n° 8043 PL-3579.1 2541777 to m No Hits found

2542187 SΞQ ID n~2779

Contig9 from

SEQ ID n° 8044 PL-5925.1 2542279 to m No Hits found

2542419 #N/A

Contig9 from

SEQ ID n° 8045 PL-5926.1 2542479 to m No Hits found

2542724 #N/A

Contig9 from gb|AAG54536.l|AE005199_6 (AE005199) Z0267 gène

SEQ ID n° 8046 PL-1604.1 2543174 to 413 product [Escherichia coli 0157 :H7]

2545288 SEQ ID n~706

Contig9 from

SΞQ ID n° 8047 PL-1605.1 2545291 to No Hits found

2546649 SEQ ID n~Y07

TABLEAU II

pir||Ξ83542 hypothetical protein PA0821

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 8048 PL-1606.1 2546654 to p 303 (strain PAOl) gb|AAG04210.l| AE004517_5

2547811 (AΞ004517) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~708

Contig9 from SEQ ID n° 8049 PL-5933.1 2547849 to No Hits found

2548082 #N/A Contig9 from sp|P5522θ|VRP2_SALEN 65 KD VIRULENCE PROTEIN SEQ ID n° 8050 PL-1607.1 2548163 to 433 dbj [BAA03383.l| (D14490) SpvB [Salmonella

2549389 enteritidis] SΞQ ID n~709 Contig9 from SEQ ID n° 8051 PL-5936.1 2550025 to No Hits found

2550258 #N/A Contig9 from SEQ ID n° 8052 PL-1608.1 2550301 to No Hits found

2551659 SΞQ ID n~710 pir| |E83542 hypothetical protein PA0821

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 8053 PL-1609.1 2551676 to p 313 (strain PAOl) gb| AAG04210.l| AΞ004517__5

2552821 (AΞ004517) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~711 pir||Ξ83542 hypothetical protein PA0821

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 8054 PL-1610.1 2552858 to p 31% (strain PAOl) gb|AAG04210.l[AE004517_5

2554003 (AΞ004517) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~713 pir( |H83457 hypothetical protein PA1508

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 8055 PL-5939.1 2554007 to 43% (strain PAOl) gb|AAG04897.l|AE004579_9

2554279 (AΞ004579) hypothetical protein [Pseudomonas aeruginosa] #N/A

Contig9 from SΞQ ID n° 8056 PL-5941.1 2555349 to m No Hits found

2555642 #N/A

TABL AU II

Contig9 from gb|AAG54714.l|AΞ005216_2 (AΞ005216) putative

SEQ ID n° 8057 PL-1611.1 2556250 to P 82% response regulator; hexosephosphate transport

2556882 [Ξscherichia coli 0157 :H7] SEQ ID n~714

Contig9 from gb|AAG54713.l|AE005216_l (AE005216) putative

SEQ ID n° 8058 PL-1612.1 2556879 to 693 sensor kinase; hexosephosphate transport

2558423 [Ξscherichia coli 0157 :H7] SEQ ID n~V15

Contig9 from gb[AAG54712.l[AΞ005215_9 (AΞ005215) putative

SEQ ID n° 8059 PL-1613.1 2558512 to 75% permease; hexosephosphate transport

2559837 [Ξscherichia coli 0157:H7] SEQ ID n~716

Contig9 from gb|AAG54711.l|AE005215_8 (AΞ005215) periplasmic

SΞQ ID n° 8060 PL-1614.1 2559851 to 863 ferrie iron-binding protein [Ξscherichia

2560885 coli 0157 :H7] SEQ ID n~717

Contig9 from gb|AAG54710.l|AE005215_7 (AE005215) putative

SΞQ ID n° 8061 PL-1615.1 2561007 to 853 permease component of transport System for

2563073 ferrie iron [Ξscherichia coli 0157 :H7] SEQ ID n~718

Contig9 from sp|P37009(AFUC_ΞCOLI PUTATIVΞ FΞRRIC TRANSPORT

SΞQ ID n° 8062 PL-1616.1 2563089 to 87% ATP-BINDING PROTEIN AFUC

2564144 SEQ ID n~719

Contig9 from

SΞQ ID n° 8063 PL-5948.1 2564316 to p No Hits found

2564516 #N/A

Contig9 from gb|AAG57125.l|AE005432_6 (AE005432) Z3231 gène

SΞQ ID n° 8064 PL-5949.1 2564513 to 733 product [Escherichia coli 0157 :H7]

2564824 #N/A pir[ [G82653 HicB-related protein XF1668

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 8065 PL-5950.1 2564875 to m 67% (strain 9a5c) gb |AAF84477.1 |AΞ003992_13

2565111 (AE003992) HicB-related protein [Xylella fastidiosa] #N/A

Contig9 from gb|AAC38629.l| (AF047028) insecticidal toxin SΞQ ID n° 8066 PL-1617.1 2565213 to 363 complex protein TccB [Photorhabdus

2569628 luminescens] SEQ ID n~720 Contig9 from gb|AAC38628.l| (AF047028) insecticidal toxin SEQ ID n° 8067 PL-1618.2 2569677 to 483 complex protein TccA [Photorhabdus

2572622 luminescens] SEQ ID n~721

TABLEAU II

Contig9 from

SΞQ ID n° 8068 PL-1619.2 2572884 to No Hits found

2575193 SΞQ ID n~Y22 pir| |T41325 probable serine-threonine dehydratase - fission yeast

(Schizosaccharomyces pombe) pir| |T41297 threonine dehydratase (EC 4.2.1.16) SPCC320.14

Contig9 from [similarity] - fission yeast SEQ ID n° 8069 PL-1620.1 2575543 to m 843 (Schizosaccharomyces pombe) emb | CAA18316.1 |

2576511 (AL022245) putative serine/threonine dehydratase

[Schizosaccharomyces pombe] emb| CAA20920.l|

(AL031603) putative serine-threonine dehydratase . [Schizosaccharomyces pombe] SEQ ID n~724

Contig9 from SEQ ID n° 8070 PL-1621.1 2576678 to No Hits found

2577304 SEQ ID n~V25 Contig9 from Sp|P55606|Y4OU_RHISN HYPOTHETICAL PROTEIN Y40U SΞQ ID n° 8071 PL-1622.1 2577659 to 683 PRECURSOR gb|AAB91807.l| (AE000089) Y4oU

2578870 [Rhizobium sp. NGR234] SEQ ID n~Y26 Contig9 from gb|AAG58297.l|AE005544_ll (AE005544) tryptophan- SEQ ID n° 8072 PL-1623.1 2579218 to 85% specific transport protein [Escherichia coli

2580462 0157 :H7] SΞQ ID n~727 Contig9 from sp ] Q59342 | TNAA_ΞNTAΞ TRYPTOPHANASΞ (L-TRYPTOPHAN SEQ ID n° 8073 PL-1624.1 2580573 to m 843 INDOLE-LYASΞ) (TNASΞ) dbj |BAA03249. l| (D14297)

2581973 tryptophanase [Ξnterobacter aerogenes] SΞQ ID n~728 pir| |B81410 probable intégral membrane protein

Contig9 from CJ0619 [imported] - Campylobacter SΞQ ID n° 8074 PL-1625.1 2583347 to 623 jejuni (strain NCTC 11168) emb(CAB75255. l[

2584687 (AL139075) putative intégral membrane protein

[Campylobacter jejuni] SΞQ ID n~729

TABLEAU II

sp | P16250 |HIS4_STRCO PHOSPHORIBOSYLFORMIMINO-5-

AMINOIMIDAZOLΞ CARBOXAMIDΞ RIBOTIDE

ISOMΞRASE pir| |JQ0641 N- (5 ' -phospho-D- ribosylformimino) -5-amino-l- (5' '-

Contig9 from phosphoribosyl) -4-imidazolecarboxamide isomerase SEQ ID n° 8075 PL-1626.1 2585598 to 64% (EC 5.3.1.16) - Streptomyces coelicolor

2586374 gb|AAA26760.l| (M31528) isomerase (hisA)

[Streptomyces coelicolor] emb | CAB51442.l|

(AL096884) phosphoribosylformimino-5- aminoimidazole carboxamide ribotide isomerase [Streptomyces coelicolor A3 (2)] SEQ ID n~730

Contig9 from SEQ ID n° 8076 PL-1627.1 2586425 to No Hits found

2587579 SEQ ID n~731 Contig9 from emb|CAB90911.l| (AL355774) putative phosphatase SEQ ID n° 8077 PL-1628.1 2587582 to 653 [Streptomyces coelicolor A3 (2)]

2588241 SEQ ID n~732 pir||F81950 probable adenylosuccinate synthase

(EC 6.3.4.4) NMA1024 [imported]

Contig9 from

Neisseria meningitidis (group A strain Z2491) SEQ ID n° 8078 PL-1629.1 2588420 to 563 emb|CAB84293.l| (AL162754) putative

2589679 adenylosuccinate synthetase [Neisseria meningitidis Z2491] SEQ ID n~Y33 sp | P41354 | MUTX_STRPN MUTATOR MUTT PROTEIN (7,8-

DIHYDRO-8-OXOGUANINE-TRIPHOSPHATASE)

Contig9 from

(8-0X0-DGTPASE) (DGTP PYROPHOSPHOHYDROLASE) SEQ ID n° 8079 PL-5955.1 2589696 to 283 pir| |S41532 ut protein - Streptococcus

2590124 pneumoniae emb |CAA79807. l| (Z21702) MutX

[Streptococcus pneumoniae] #N/A

Contig9 from SEQ ID n° 8080 PL-1630.1 2590271 to m No Hits found

2591425 SΞQ ID n~735

TABLEAU II

sp|P30130 |FIMD_ECOLI OUTER MEMBRANΞ USHER

PROTEIN FIMD PRECURSOR pir| |S56542 outer membrane usher protein fimD precursor -

Contig9 from

Ξscherichia coli gb| AAA97213. l | (U14003) CG SEQ ID n° 8081 PL-1631.1 2591518 to 56%

Site No. 18349 [Ξscherichia coli]

2594160 gb|AAC77273.l| (AΞ000502) outer membrane protein; export and assembly of type 1 fimbriae, interrupted [Escherichia coli K12] SEQ ID n~736

Contig9 from emb |CAB01713.l| (Z78535) type l fimbrial SEQ ID n° 8082 PL-1632.1 2594243 to m 37? chaperone [Proteus mirabilis]

2595100 SEQ ID n~7 7 Contig9 from gb|AAD26595.l( (AF012835) chaperone protein AafD SEQ ID n° 8083 PL-1633.1 2595131 to m 46% [Escherichia coli]

2595880 SEQ ID n~738 Contig9 from SEQ ID n° 8084 PL-3581.2 2595914 to m No Hits found

2596486 #N/A sp|P 6008]FOCC_ΞCOLI CHAPΞRONΞ PROTΞIN FOCC

Contig9 from

PRΞCURSOR pir || 141062 periplasmic chaperone SEQ ID n° 8085 PL-1634.2 2596486 to m 42% focC protein - Ξscherichia coli emb|CAA86604.l|

2597202

(Z46635) focC [Escherichia coli] #N/A

Contig9 from SEQ ID n° 8086 PL-3582.1 2597304 to No Hits found

2597864 SΞQ ID n~2783 Contig9 from SEQ ID n° 8087 PL-1635.1 2598188 to No Hits found

2599342 SΞQ ID n~740 sp|P30130|FIMD_ΞCOLI OUTΞR MΞMBRANΞ USHER

PROTEIN FIMD PRECURSOR pir[ |S56542 outer membrane usher protein fi D precursor -

Contig9 from

Escherichia coli gb| AAA97213. l| (U14003) CG SEQ ID n° 8088 PL-1636.1 2599489 to 57%

Site No. 18349 [Escherichia coli]

2602131 gb|AAC77273.l| (AE000502) outer membrane protein; export and assembly of type 1 fimbriae, interrupted [Escherichia coli K12] SEQ ID n~Y41

eo t- t •* t- -

> < t#* &-

< 1 <; ! ! ! i ! fi fi fi fi fi s^' fi fi fi fi fi

P Q Q O # Q O n Q

H α a α σ α α α α w w w H H P-l H w w w m

fi fi fi ti o ta tn

-ri -ri K ffi

A" o o oo co ro S3 1-5 m r-

en o ro <* r~ en eo en ai en en σ σ o o o co co co co

Q Ω Q o a o

H n σ a a σ σ a σ

H m a a

H m w W m tn TABLEAU II

Contig9 from emb[CAA83636.l| (Z32686) rpD [Proteus SEQ ID n° 8100 PL-1643.1 2610058 to m 83% mirabilis]

2610807 SEQ ID n~748 Contig9 from embjCAA83635.l| (Z32686) mrpC [Proteus SEQ ID n° 8101 PL-1644.1 2610931 to 75% mirabilis]

2613447 SEQ ID n~749

Contig9 from emb|CAA83634.l| (Z32686) mrpB [Proteus SEQ ID n° 8102 PL-3591.1 2613506 to m 50% mirabilis]

2613943 SEQ ID n~2790 sp|Q0301l|MRPA_PROMI MAJOR MR/P FIMBRIA PROTEIN

PRECURSOR pir| | A40643 MR/P fimbriae, major

Contig9 from fimbrial subunit - Proteus mirabilis SEQ ID n° 8103 PL-1645.1 2614138 to m 67 emb|CAA79244.l| (Z18753) MR/P major fimbrial

2614677 subunit polypeptide [Proteus mirabilis] emb| CAA83633. l| (Z32686) mrpA

[Proteus mirabilis] SΞQ ID n~750

Contig9 from emb|CAB61438.l| (Z32686) MrpI [Proteus SEQ ID n° 8104 PL-1646.1 2615361 to 78 mirabilis]

2615933 SEQ ID n~Y51 Contig9 from emb[CAB54047.l| (AJ245436) hypothetical protein, SΞQ ID n° 8105 PL-1647.1 2617192 to 383 21.8 kD [Pseudomonas putida]

2617806 SEQ ID n~752 Contig9 from SEQ ID n° 8106 PL-5969.1 2618006 to No Hits found

2618209 #N/A sp|P11830 |ACP_SACER ACYL CARRIER PROTEIN (ACP)

Contig9 from pir| |A47030 acyl carrier protein - SEQ ID n° 8107 PL-5971.1 2618915 to P 543 Saccharopolyspora erythraea gb|AAA26476.l|

2619178 (M64477) acyl carrier protein [Saccharopolyspora erythraea] #N/A

Contig9 from SΞQ ID n° 8108 PL-1648.1 2619180 to No Hits found

2620058 SEQ ID n~753 Contig9 from SEQ ID n° 8109 PL-1649.1 2620069 to No Hits found

2620743 SEQ ID n~V54

TABLEAU II

pir] |T45319 hypothetical protein MLCB1779.31

Contig9 from

[imported] - Mycobacterium leprae SΞQ ID n° 8110 PL-1650.1 2620736 to 3c emb|CAB11012.l| (Z98271) hypothetical protein

2621815

MLCB1779.31 [Mycobacterium leprae] SEQ ID n~y56 pir| |H70158 conserved hypothetical intégral

Contig9 from membrane protein BB0473 - Lyme SEQ ID n° 8111 PL-1651.1 2621820 to 34% disease spirochete gb|AAC66867.l| (AEO 01152)

2623220 conserved hypothetical intégral membrane protein

[Borrelia burgdorferi] SEQ ID n~757 pir[ [A69831 probable acid--CoA ligase (EC 6.2.1.-

) yhfL [similarity] - Bacillus

Contig9 from subtilis emb|CAA74533.l| (Y14083) hypothetical SEQ ID n° 8112 PL-1652.1 2623246 to 463 protein [Bacillus subtilis] emb| CAB12867.1 |

2624823

(Z99109) similar to long-chain fatty-acid-CoA ligase [Bacillus subtilis] SΞQ ID n~758 pir| |D83099 probable RND efflux membrane fusion protein precursor PA4374 [imported] -

Contig9 from

Pseudomonas aeruginosa (strain PAOl) SΞQ ID n° 8113 PL-1653.1 2624820 to p 45% gb|AAG07762.l|AΞ004853_5 (AE004853) probable RND

2625893 efflux membrane fusion protein precursor

[Pseudomonas aeruginosa] SEQ ID n~759 pir| |A82357 probable multidrug résistance

Contig9 from protein VC0164 [imported] - Vibrio SEQ ID n° 8114 PL-1654.1 2625890 to p 563 cholerae (group 01 strain N16961)

2628931 gb|AAF93340.l| (AE004106) multidrug résistance protein, putative [Vibrio cholerae] SEQ ID n~760 s | P30790 | FABH_RHOCA 3 -OXOACYL- [ACYL-CARRIER- PROTEIN] SYNTHASE III (BETA-KETOACYL-ACP

Contig9 from

SYNTHASE III) (KAS III) pir||C41608 SEQ ID n° 8115 PL-1655.1 2628928 to 423 hypothetical protein 3 (himA 5 ' région) -

2629875

Rhodobacter capsulatus gb [AAA26127. l| (M84030)

0RF3; putative [Rhodobacter capsulatus] SEQ ID n~y61

TABLEAU II

pir|]E82182 enterobactin synthetase component F- related protein VC1579 [imported] -

Contig9 from

Vibrio cholerae (group 01 strain N16961) SEQ ID n° 8116 PL-1656.1 2629872 to 503 gb|AAF94733.l| (AE004235) enterobactin

2631437 synthetase component F-related protein

[Vibrio cholerae] SEQ ID n~V62

Contig9 from pir| |S76481 hypothetical protein - Synechocystis SEQ ID n° 8117 PL-1657.1 2631777 to 24% sp. (strain PCC 6803) dbj |BAA18610.l| (D90915)

2632736 hypothetical protein [Synechocystis sp.] SEQ ID n~763 Contig9 from SEQ ID n° 8118 PL-1658.1 2632729 to No Hits found

2633643 SΞQ ID n~764 s | 067185 | FABH_AQUAE 3 -OXOACYL- [ACYL-CARRIER- PROTEIN] SYNTHASE III (BETA-KETOACYL-ACP

Contig9 from SYNTHASE III) (KAS III) pir| |F70394 3-oxoacyl- SEQ ID n° 8119 PL-1659.1 2633649 to 38% [acyl-carrier-protein] synthase III - Aquifex

2634587 aeolicus gb|AAC07i44.l[ (AE000723) 3 -oxoacyl- [acyl-carrier-protein] synthase III [Aquifex aeolicus] SEQ ID n~765

Contig9 from dbj |BAB18473.1 (AB033991) BtrK [Bacillus SEQ ID n° 8120 PL-1660.1 2634928 to 50% circulans]

2636187 SEQ ID n~767 Contig9 from SEQ ID n° 8121 PL-5975.1 2637063 to m No Hits found

2637269 #N/A Contig9 from gb|AAG57863.1 |AE005503_4 (AE005503) orf; SEQ ID n° 8122 PL-1661.1 2637813 to m 51? hypothetical protein [Escherichia coli 0157.-H7]

2638493 SEQ ID n~768 Contig9 from gb|AAG57864.l|AE005503_5 (AE005503) orf; SEQ ID n° 8123 PL-1662.1 2638474 to m 47? hypothetical protein [Escherichia coli 0157 :H7]

2639220 SEQ ID n~769 Contig9 from gb|AAG57865.l[AE005503_6 (AE005503) Z4067 gène SEQ ID n° 8124 PL-1663.1 2639231 to m 673 product [Escherichia coli 0157 :H7]

2640265 SEQ ID n~770

TABLEAU II

Contig9 from gb|AAG57866.l|AE005503_7 (AE005503) Z4068 gène SEQ ID n° 8125 PL-3592.1 2640286 to m 39% product [Escherichia coli 0157 :H7]

2640867 SEQ ID n~2791 Contig9 from gb|AAG57867.l|AE005503_8 (AE005503) orf; SEQ ID n° 8126 PL-1664.1 2640867 to m 50% hypothetical protein [Escherichia coli 0157 :H7]

2642471 SEQ ID n~771 Contig9 from gb|AAG57868.l|AE005503_9 (AE005503) orf; SEQ ID n° 8127 PL-1665.1 2642486 to m 48% hypothetical protein [Escherichia coli 0157 :H7]

2645203 SΞQ ID n~772 Contig9 from gb|AAF08816.l|AF194079_3 (AF194079) Toul SEQ ID n° 8128 PL-1666.2 2645725 to m 28% [Neisseria meningitidis]

2647179 SEQ ID n~773 Contig9 from gb|AAK06058.l|AΞ006426_4 (AE006426) HYPOTHΞTICAL SEQ ID n° 8129 PL-3593.1 2647264 to m 45% PROTEIN [Lactococcus lactis subsp. lactis]

2647815 SEQ ID n-2792 Contig9 from SEQ ID n° 8130 PL-1667.1 2648312 to m No Hits found

2649343 SEQ ID n~774 pir| |E83406 probable sigma-70 factor, ECF subfamily PA1912 [imported] -

Contig9 from

Pseudomonas aeruginosa (strain PAOl) SEQ ID n° 8131 PL-3594.1 2650299 to 653 gb|AAG05300.l|AE004617_4 (AΞ004617) probable

2650808 sigma-70 factor, ECF subfamily [Pseudomonas aeruginosa] SEQ ID n~2793 pir| |D83406 probable transmembrane sensor PA1911

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 8132 PL-1668.1 2650787 to 47? (strain PAOl) gb|AAG05299.1 | AE004617_3

2651800 (AE004617) probable transmembrane sensor

[Pseudomonas aeruginosa] SEQ ID n~775 pir||C83035 hypothetical protein PA4897

Contigg from [imported] - Pseudomonas aeruginosa SEQ ID n° 8133 PL-1669.1 2651887 to 49? (strain PAOl) gb|AAG08282.1 |AE004902_10

2654490 (AE004902) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~776

TABLEAU II

ref (NP_073225.l| ransposase of IS630 [Salmonella enterica serovar Choleraesuis] dbj |BAA01531.1 |

Contig9 from

(D10689) M5 protein [Salmonella choleraesuis] SEQ ID n° 8134 PL-1670.1 2654828 to m 723 dbj (BAB20556.1| (AB040415) ransposase of IS630

2655841

[Salmonella enterica serovar

Choleraesuis] SEQ ID n~778 pirj [T37097 probable secreted neuraminidase -

Contig9 from

Streptomyces coelicolor emb |CAB52948. l| SEQ ID n° 8135 PL-1671.1 2656069 to 273

(AL109950) putative secreted neuraminidase

2657184

[Streptomyces coelicolor A3 (2)] SEQ ID n~779 pir| [T34699 hypothetical protein SC1C3.07

Contig9 from SC1C3.07 - Streptomyces coelicolor SEQ ID n° 8136 PL-1672.1 2657728 to 253 emb(CAA19231.l| (AL023702) hypothetical protein

2658837 SC1C3.07 [Streptomyces coelicolor

A3 (2)] SΞQ ID n~780 pir| [T37097 probable secreted neuraminidase -

Contig9 from

Streptomyces coelicolor emb|CAB52948. l| SΞQ ID n° 8137 PL-1673.1 2659334 to 293

(AL109950) putative secreted neuraminidase

2660449

[Streptomyces coelicolor A3 (2)] SEQ ID n~781 pir| [T37097 probable secreted neuraminidase -

ContigS from

Streptomyces coelicolor emb[CAB52948.1 | SΞQ ID n° 8138 PL-1674.1 2660909 to 29%

(AL109950) putative secreted neuraminidase

2662024

[Streptomyces coelicolor A3 (2)] SEQ ID n~782

Contig9 from SEQ ID n° 8139 PL-5982.1 2662092 to m No Hits found

2662310 #N/A pir| [T37097 probable secreted neuraminidase

Contig9 from Streptomyces coelicolor emb | CAB52948.1 | SEQ ID n° 8140 PL-1675.1 2662687 to 31? (AL109950) putative secreted neuraminidase

2663817 [Streptomyces coelicolor A3 (2)] SEQ ID n~783

Contig9 from SEQ ID n° 8141 PL-5986.1 2664866 to No Hits found

2665045 #N/A

TABLEAU II

sp|P18837|SFSB_ECOLI SUGAR FERMENTATION

STIMULATION PROTEIN B (NER-LIKE PROTEIN) pir | [ BVECNP nlp protein - Escherichia coli emb|CAA48736.l| (X68873) Ner-like protein, homologous to Ner protein of bacteriophages Mu and D108 [Escherichia coli]

Contig9 from gb|AAA57989.l] (U18997) Ner-like protein SEQ ID n° 8142 PL-5988.1 2665260 to m 633 [Escherichia coli] gb | AAC76220.1 | (AE000399)

2665514 regulatory factor of maltose metabolism,- similar to Ner repressor protein of phage Mu

[Escherichia coli K12] gb|AAG58322.l[AE005547_8 (AE005547) regulatory factor of maltose metabolism; similar to Ner repressor protein of phage Mu [Escherichia coli 0157 :H7] #N/A sp|034864[Y0AB_BACSU PUTATIVE TRANSPORTER YOAB pir| |D69895 conserved hypothetical protein yoaB •

Contig9 from Bacillus subtilis gb| AAB84444.l| (AF027868) SEQ ID n° 8143 PL-1676.1 2665718 to m 64% putative transporter [Bacillus subtilis]

2667004 emb|CAB13747.l| (Z99114) similar to hypothetical proteins from B. subtilis [Bacillus subtilis] SEQ ID n~784 sp|Q9WYP7|Y416_THEMA HYPOTHETICAL PROTEIN TM0416 pir[ |F72381 D-tagatose 3 -epimerase-related

Contig9 from protein - Thermotoga maritima (strain SEQ ID n° 8144 PL-5990.1 2667445 to 553

MSB8) gb|AAD35501.l|AE001720_15 (AE001720) D-

2667828 tagatose 3-epimerase-related protein [Thermotoga maritima] #N/A

Contig9 from SEQ ID n° 8145 PL-3596.1 2667885 to No Hits found

2668190 SEQ ID n~2794 Contig9 from ref |NP_059785.l| ync [Agrobacterium tumefaciens] SEQ ID n° 8146 PL-5993.1 2669097 to m 443 gb|AAD50321.lj (AF242881) ync [Agrobacterium

2669249 tumefaciens] #N/A

TABLEAU II

Contig9 from ref |NP__059786.l| ynd [Agrobacterium tumefaciens] SEQ ID n° 8147 PL-5994.1 2669275 to m 46% gb|AAF77152.l| (AF242881) ynd [Agrobacterium

2669517 tumefaciens] #N/A Contig9 from gb|AAG57842.l|AE005501_ll (AΞ005501) methyl- SEQ ID n° 8148 PL-1677.1 2669753 to p 89% directed mismatch repair [Ξscherichia coli

2672308 0157:H7] SEQ ID n~785 pir| |H82142 tRNA- (MS [2] 10 [6] A) -hydroxylase

Contig9 from VC1910 [imported] - Vibrio cholerae SEQ ID n° 8149 PL-1678.1 2672313 to p 83% (group 01 strain N16961) gb|AAF95058.l|

2673074 (AΞ004266) tRNA- (MS [2] IO[6]A) -hydroxylase

[Vibrio cholerae] SEQ ID n~786

Contig9 from dbj (BAB06239.1( (AP001515) transposase related SEQ ID n° 8150 PL-1679.1 2673556 to p 21% protein (20) [Bacillus halodurans]

2674581 SEQ ID n~787 Contig9 from gb[AAF20816.l|AF198628_2 (AF198628) RpoS SEQ ID n° 8151 PL-1680.1 2675594 to m 95% [Xenorhabdus nematophilus]

2676592 SEQ ID n~Y89 Contig9 from emb|CAA0688i.l| (AJ006131) nlpD [Salmonella SEQ ID n° 8152 PL-1681.1 2676644 to m 70% dublin]

2677639 SEQ ID n~790

TABLEAU II

sp|P24206|PIMT_ECOLI PROTEIN-L-ISOASPARTATE O-

MΞTHYLTRANSFERASE (PROTEIN-BΞTA-ASPARTATE

METHYLTRANSFERASE) (PIMT) (PROTEIN L-ISOASPARTYL

METHYLTRANSFERASE) (L-ISOASPARTYL PROTEIN

CARBOXYL METHYLTRANSFERASE) pir| |JH0242 protein-L-isoaspartate (D-aspartate)

O-methyltransferase (EC 2.1.1.77) type II - Escherichia coli gb[ AAA24302.l|

Contig9 from

(M63493) L-isoaspartyl protein carboxyl

SEQ ID n° 8153 PL-1682.1 2677791 to 833 methyltransferase [Ξscherichia coli]

2678417 gb|AAA69253.l| (U29579) L-isoaspartyl protein carboxyl methyltransferase type II

[Ξscherichia coli] gb |AAC75785.1 | (AE000358) L- isoaspartate protein carboxylmethyltransferase type II [Escherichia coli K12] gb|AAG57850.l|AE005502_4 (AE005502) L- isoaspartate protein carboxylmethyltransferase type II [Escherichia coli θl57:H7] SEQ ID n~V91 gb|AAA69254.l| (U29579) alternate name ygbC;

Contig9 from

ORF1 of L07942, has différent start

SEQ ID n° 8154 PL-1683.1 2678411 to 723 due to frameshift in L07942; ORF_f255

2679175

[Escherichia coli] SEQ ID n~792 sp|Q5726l|YGBO_ECOLI 39.1 KDA PROTEIN IN SURE- CYSC INTERGENIC REGION pir || 169731 hypothetical protein b2745 - Escherichia coli gb (AAA69255.1 |

Contig9 from (U29579) as ORF_f292 and ORF_f255 before SEQ ID n° 8155 PL-1684.1 2679153 to m 71% splice; ORF__f349 [Escherichia coli]

2680205 gb|AAA79838.l| (L07942) 0RF1 [Escherichia coli] gb|AAC75787.l| (AE000358) putative hydrogenase subunit [Escherichia coli K12] SEQ ID n~793

TABLEAU II

sp|P36663|lSPF__ECOLI 2C-METHYL-D-ΞRYTHRIT0L 2,4-

CYCLODIPHOSPHATE SYNTHASE (MECPS) pir [| 155083 hypothetical 16.9K protein (surΞ-cysC intergenic région) - Escherichia coli gb[AAA79837.l| (L07942) ORF0 [Ξscherichia coli] gb|AAA69256.l| (U29579) alternate gène name ygbB; ORF0 of L07942; ORF_fl59

Contig9 from

[Escherichia coli] gb| AAC75788.11 (AE000358) SEQ ID n° 8156 PL-3597.1 2680206 to m 80- orf, hypothetical protein [Escherichia coli K12]

2680679 gb]AAF44656.l|AF230738_l (AF230738) 2C-methyl-D- erythritol 2,4-cyclodiphosphate synthase

[Escherichia coli] dbj |BAA95145.1 | (AB038256) 2-

C-methyl-D-erythritol 2 , 4-cyclodiphosphate synthase [Escherichia coli] gb|AAG57853.l|AΞ005502_7 (AE005502) orf, hypothetical protein [Ξscherichia coli 0157 :H7] SEQ ID n~2795 sp [ Q46893 | ISPD_ECOLI 4-DIPHOSPHOCYTIDYL-2C-

METHYL-D-ERYTHRITOL SYNTHASE (MEP

CYTIDYLYLTRANSFΞRASΞ) (MCT) pir||G65055 hypothetical protein b2747 - Escherichia coli

(strain K-12) gb|AAA69257. l| (U29579) ORF_f236

Contig9 from [Escherichia coli] gb] AAC75789.l| (AE000358) SEQ ID n° 8157 PL- 1685.1 2680693 to m 693 orf, hypothetical protein [Escherichia coli K12]

2681424 dbj ]BAA90761.l| (AB037143) 2-C-methyl-D- erythritol 4-phosphate cytidylyltransferase

[Escherichia coli] gb| AAF43207. l|AF230736_l

(AF230736) 4-diphosphocytidyl-2C-methyl-D- erythritol synthase [Escherichia coli] SEQ ID n~794

Contig9 from gb]AAG42461.l|AF308468_2 (AF308468) YgbQ

SEQ ID n° 8158 PL-5998.1 2681430 to 713 [Klebsiella aerogenes]

2681750 #N/A

Contig9 from gb|AAG42463.l|AF308468_4 (AF308468) APS kinase

SEQ ID n° 8159 PL- 1686.1 2681897 to 73% [Klebsiella aerogenes]

2682529 SEQ ID n~795

TABLEAU II

Contig9 from gb|AAG42464.l|AF308468_5 (AF308468) ATP SΞQ ID n° 8160 PL-1687.1 2682531 to m 79% sulfurylase N subunit [Klebsiella aerogenes]

2683916 SΞQ ID n~796 Contig9 from gb|AAG42465.l]AF308468_6 (AF308468) ATP SEQ ID n° 8161 PL-1688.1 2683985 to m 93% sulfurylase D subunit [Klebsiella aerogenes]

2684893 SΞQ ID n~797 Contig9 from gb|AAG42466.l|AF308468_7 (AF308468) siroheme SEQ ID n° 8162 PL-1689.1 2684903 to m 73% synthetase [Klebsiella aerogenes]

2686315 SEQ ID n~Y98 Contig9 from SEQ ID n° 8163 PL-6000.1

Contig9 from gb|AAG58616.l|AE005572_14 (AE005572) Z4882 gène SΞQ ID n° 8164 PL-6001.1 2686855 to p 83% product [Escherichia coli 0157.-H7]

2687211 #N/A sp | P17853 | CYSH_SALTY PHOSPHOADENOSINE

PHOSPHOSULFATE REDUCTASE (PAPS REDUCTASE,

THIOREDOXIN DEPENDENT) (PADOPS REDUCTASE)

O'-PHOSPHOADENYLYLSULFATE REDUCTASE) (PAPS

Contig9 from

SULFOTRANSFERASE) pir]|C34354 3'- SEQ ID n° 8165 PL-1690.1 2687317 to m 783 phosphoadenosine 5 ' -phosphosulfate reductase (ΞC

2688051

1.8.99.4) - Salmonella typhimurium gb|AAA27048.l| (M23007) 3 ' -phosphoadenosine-5 ' - phosphosulfate sulfotransferase

[Salmonella typhimurium] SEQ ID n~800

ContigS from gb|AAG57871.l|AE005504_3 (AE005504) sulfite SEQ ID n° 8166 PL-1692.1 2688048 to m 87? reductase, alpha subunit [Ξscherichia coli

2689778 0157:H7] SEQ ID n~801 sp|P38038 |CYS _ECOLI SULFITE REDUCTASE [NADPH]

FLAVOPROTEIN ALPHA-COMPONENT (SIR-FP)

Contig9 from pir| |B34231 sulfite reductase (NADPH) (EC SEQ ID n° 8167 PL-1693.1 2689778 to m 813

1.8.1.2) - Escherichia coli gb|AAA23650. l|

2691580

(M23008) NADPH-sulfite reducatase flavoprotein component [Escherichia coli] SEQ ID n~802

TABLEAU II

sp|Q46903|PTPS_ΞCOLI PUTATIVΞ 6-PYRUVOYL

TΞTRAHYDROBIOPTERIN SYNTHASE (PTPS) (PTP

SYNTHASE) pir| |A65058 hypothetical protein b2765 - Escherichia coli (strain K-12)

Contig9 from gb|AAA69275.l| (U29579) ORF_ol21 [Escherichia SEQ ID n° 8168 PL-6002.1 2691847 to p 823 coli] gb|AAC75807.l| (AE000360) putative 6-

2692209 pyruvoyl tetrahydrobiopterin synthase

[Escherichia coli K12] gb|AAG57873.1 ]AE005504__5

(AE005504) putative 6-pyruvoyl tetrahydrobiopterin synthase

[Escherichia coli 0157.-H7] #N/A

Contig9 from gb|AAG57887.l|AE005505_5 (AE005505) orf,

SEQ ID n° 8169 PL-1694.1 2692254 to m 803 hypothetical protein [Escherichia coli 0157 :H7]

2692925 SEQ ID n~803

Contig9 from gb|AAB86967.l| (AF032970) inducible histidine

SEQ ID n° 8170 PL-1695.1 2693096 to 82% transporter [Pseudomonas putida]

2694481 SEQ ID n~804 pir||C64745 yafD protein - Escherichia coli

Contig9 from gb|AAC73314.l[ (AE000130) orf, hypothetical SEQ ID n° 8171 PL-1696.1 2694757 to m 761 protein [Escherichia coli K12]

2695539 gb|AAG54505.l|AE005196_3 (AE005196) orf, hypothetical protein [Ξscherichia coli 0157 :H7] SEQ ID n~805 sp|P31546|YAΞD_ECOLI HYPOTHETICAL 21.3 KD

PROTEIN IN ABC-RRSH INTERGENIC REGION pir| |H64744 yaeD protein - Escherichia coli gb|AAB08628.l| (U70214) hypothetical

[Escherichia coli] gb|AAC733ll.l| (AE000129)

Contig9 from putative phosphatase [Ξscherichia coli K12] SEQ ID n° 8172 PL-1578.1 2701657 to m 723 dbj |BAA77877.l| (D83536) Hypothetical 21.3 kd

2702223 protein in abc-rrnH intergenic région. [Escherichia coli] dbj |BAA93568. l|

(AB035926) phosphatase [Escherichia coli

0157:H7] gb|AAG5450 . l| AE005195_11 (AE005195) putative phosphatase [Escherichia coli 0157 :H7] SEQ ID n~S76

TABLEAU II

Contig9 from gb|AAG54501.l|AE005195_10 (AE005195) ATP-binding SEQ ID n° 8173 PL-1577.1 2702419 to 88% component of a transporter [Escherichia coli

2703450 0157 :H7] SΞQ ID n~β75 sp|P31547|YAEE_ΞCOLI HYPOTHETICAL ABC TRANSPORTΞR PERMEASE PROTEIN YAEE pir| JF64744 probable transport protein yaeΞ - Ξscherichia coli gb^"1 AAB08626Tr| ^"(U70214) hypothetical

Contig9 from

[Escherichia coli] gb|AAC73309.1 | (AE000129)

SEQ ID n° 8174 PL-1576.1 2703443 to p 92% putative transport system permease protein

2704096

[Ξscherichia coli K12] dbj |BAA77875-.l| (D83536) Hypothetical 23.3 kd protein in rcsF-abc intergenic région. [Ξscherichia coli] SΞQ ID n~Θ74 sp|P28635| AEC_ECOLI PUTATIVE LIPOPROTEIN YAEC

PRΞCURSOR pir] |E64744 probable lipoprotein yaeC

- Escherichia coli dbj |BAA03657.1 | (D15061)

ORF271 [Escherichia coli] gb|AAB08625.l|

Contig9 from

(U70214) hypothetical [Escherichia coli]

SEQ ID n° 8175 PL-1575.1 2704162 to 943 gb|AAC73308.l| (AΞ000129) putative lipoprotein

2704977

[Escherichia coli K12] dbj [BAA7787 . l| (D83536)

Hypothetical 29.4 kd lipoprotein in rcsF-abc intergenic région precursor.

[Escherichia coli] SEQ ID n~873 sp|P28633| CSF_ECOLI RCSF PROTEIN pir||B47040 exopolysaccharide synthesis regulator RcsF -

Contig9 from

Escherichia coli gb| AA24508.1 | (L04474) rcsF

SEQ ID n° 8176 PL-6032.1 2705120 to 55%

[Escherichia coli] dbj |BAA77873.1 | (D83536)

2705518

Exopolysaccharide synthesis regulator RcsF.

[Escherichia coli] #N/A

TABLEAU II

sp|P28634|YAΞB_ECOLI HYPOTHETICAL 26.4 KDA

PROTEIN IN PROS-RCSF INTERGENIC REGION (ORF3) pir| | C64744 yaeB protein - Escherichia coli dbj |BAA03655.1 | (D15061) ORF235 [Escherichia

Contig9 from coli] gb|AAB08623.l| (U70214) hypothetical SEQ ID n° 8177 PL-1574.1 2705515 to 753

[Escherichia coli] gb | AAC73306.1 | (AE000128) 27-06222 orf7 hypothetical protein [Escherichia coli K12] db |BAA77871.1 | (D83536) Hypothetical 26.4 kd protein in proS-rcsF intergenic région (orf3) . [Escherichia coli] SΞQ ID n~672

Contig9 from gb|AAG54496.l|AΞ005195_5 (AE005195) proline tRNA

SΞQ ID n° 8178 PL-1573.1 2706348 to 913 synthetase [Escherichia coli 0157 :H7]

2708066 SEQ ID n~071

Contig9 from gb|AAG54494.1 |AE005195_3 (AE005195) copper

SΞQ ID n° 8179 PL-1572.1 2708168 to 543 homeostasis protein (lipoprotein) [Escherichia

2708839 coli 0157 :H7] SEQ ID n~θ 70 pir| |E64743 yaeo protein - Escherichia coli emb|CAA90752.l| (Z50870) orf4 [Escherichia coli]

Contig9 from gb|AAC73300.l| (AE000128) orf, hypothetical SΞQ ID n° 8180 PL-6035.1 2709174 to 713 protein [Escherichia coli K12]

2709440 gb|AAG54491.l[AE005194_12 (AE005194) orf, hypothetical protein [Escherichia coli 0157.-H7] / sp|P52097|MESJ_ΞCOLI PUTATIVE CELL CYCLE PROTEIN

MESJ pir| |D64743 cell cycle protein mesJ -

Escherichia coli emb| CAA90751. l| (Z50870) similar to Ace. o. D26185 [Escherichia coli]

Contig9 from dbj |BAA08428.l| (D49445) YaeN [Escherichia coli] SEQ ID n° 8181 PL-1571.1 2709473 to m 643 gb|AAB08617.l( (U70214) hypothetical

2710801

[Escherichia coli] gb | AAC73299.1 | (AE000128) cell cycle protein [Escherichia coli K12] dbj |BAA77863.l| (D83536) Cell cycle protein

MesJ. [Ξscherichia coli] SEQ ID n~669

TABLEAU II

Sp|P30867|ACCA_ΞCOLI ACETYL-COENZYME A

CARBOXYLASE CARBOXYL_^TRANSFERASE SUBUNIT ALPHA pir| |A43452 acetyl-CoA carboxylase (EC 6.4.1.2) carboxyïtransferase ^~aïpha chain

[validated] - Escherichia coli gb| AA70370.l|

(M96394) acetyl-CoA carboxylase [Escherichia coli] gb | Â B ÏTTI (U70214) acetyl-CoA

Contig9 from carboxylase alpha subunit [Escherichia coli] SEQ ID n° 8182 PL-1570.1 2711140 to m 92^; dbj |BAA08425.l| (D49445) AccA, alpha subunit of

2712099 acetyl-coA carboxylase [Escherichia coli] gb|AAC73-296τl| (AΞ000127) acetylCoA carboxylase, carboxytransferase component, alpha subunit [Escherichia coli K12] gb|AAG54487.l|AE005194_8 (AE005194) acetylCoA carboxylase, carboxytransferase component, alpha subunit [Escherichia coli 0157 :H7] SEQ ID n~β68

Contig9 from gb|AAG54486.L AE005194_7 (AΞ005194) DNA SEQ ID n° 8183 PL-1569.1 2712113 to 923 polymerase III, alpha subunit [Escherichia coli

2715595 0157:H7] SEQ ID n~β66 sp|P10442|RNH2_ECOLI RIBONUCLEASE HIl (RNASE

HIl) pir||QQECBE ribonuclease H (EC 3.1.26.4)

Contig9 from II - Escherichia coli gb| AAB08612.1 | (U70214) SΞQ ID n° 8184 PL-3600.1 2715649 to 813 ribonuclease HIl [Escherichia coli]

2716239 gb|AAC73294.l] (AE000127) RNAse HIl, dégrades

RNA of DNA-RNA hybrids [Escherichia coli K12] SEQ ID n~2799 pir||SYECLA lipid-A-disaccharide synthase (ΞC

2.4.1.182) - Escherichia coli gb[AAB08611.l|

Contig9 from

(U70214) lipid A disaccharide synthase SΞQ ID n° 8185 PL-1568.1 2716239 to 85%

[Ξscherichia coli] gb |AAC73293.1 | (AE000127)

2717408 tetraacyldisaccharide-1-P; lipid A biosynthesis, penultimate step [Escherichia coli K12] SEQ ID n~θ65

TABLEAU II

sp | P72215 | LPXA_PROMI ACYL- [ACYL-CARRIER-PROTEIN]

Contig9 from -UDP-N-ACETYLGLUCOSAMINE _ 0_:, SΞQ ID n° 8186 PL-1567.1 2717428 to m _913 ACYLTRANSFERASE (UDP-N-ACETYLGLUCOSAMINE

2718216 ACYLTRANSFERASE) emb | CAA70456.11 (Y09 63) lpxA [Proteus mirabilis] SΞQ ID n~β64 sp | P32205 | FABZ_YERΞN (3R) -HYDROXYMYRISTOYL- [ACYL

CARRIER PROTEIN] DEHYDRATASE pir | | S35968 ^"(3R) -

Contig9 from hydroxymyristoyl- [acyl carrier protein] SEQ ID n° 8187 PL-6038.1 2718220 to m 89% dehydratase (EC 4.2.1.-) - Yersinia

2718672 enterocolitica emb| CAA80952. l| (Z25463) unknown

[Yersinia enterocôXiticâ] #N/A sp|P32203|LPXD_YEREN UDP-3-0- [3-

HYDROXYMYRISTOYL] GLUCOSAMINΞ N-ACYLTRANSFERASE

(FIRA PROTEIN) (RIFAMPICIN RESISTANCE

Contig9 from

PROTEIN) pir||S41752 UDP-3-0-[3- SΞQ ID n° 8188 PL-1565.1 2718835 to 883 hydroxymyristoyl] glucosamine N-acyltransferase

2719863

(EC 2.3.1.-) - Yersinia enterocolitica emb|CAA80951.l| (Z25463) FirA

[Yersinia enterocolitica] SEQ ID n~662

Contig9 from emb[CAB51930.l| (AJ236920) periplasmic protein SΞQ ID n° 8189 PL-1564.1 2719867 to 77% [Photorhabdus luminescens]

2720364 SEQ ID n~θ61 Contig9 from emb|CAB5l929. l| (AJ236920) outer membrane SEQ ID n° 8190 PL-1563.1 2720475 to 96? antigen [Photorhabdus luminescens]

2722868 SEQ ID n~θ60 sp|P37764|YAEL_ECOLI HYPOTHETICAL 49.1 KDA

PROTEIN IN CDSA-HLPA INTERGENIC REGION pir( (H64741 yaeL protein - Escherichia coli gb|AAB08605.l| (U70214) hypothetical

Contig9 from [Escherichia coli] gb|AAC73287.l| (AE000127) SEQ ID n° 8191 PL-1562.1 2722903 to 81% orf, hypothetical protein [Escherichia coli K12]

2724258 dbj |BAA77851.l| (D83536) Hypothetical 49.1 kd protein in cdsA-hlpA intergenic r gion. [Escherichia coli] gb|AAG54478.l|AE005193_8 (AE005193) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~β59

TABLEAU II

sp | PO6 66 | CDSA_ΞCOLI PHOSPHATIDATE

CYTIDYLYLTRANSFERASE (CDP-DIGLYCERIDE

SYNTHETASE) (CDP-DIGLYCERIDE

PYROPHOSPHORYLASE (CDP-DIACYLGLYCEROL SYNTHASE) (CDS) (CTP : PHOSPHATIDATE CYTIDYLYLTRANSFERASE (CDP-DAG

SΫNTHASΞ) (CDP-DG^~SYNTHETASΞ) pir| SYΞCDG phosphatidate cytidylyltransferase (EC 2.7.7.41)

Contig9 from - Escherichia coli gb|AAA23545.l| (M11330) CDP- SEQ ID n° 8192 PL-1561.1 2724287 to m 63% diglyceride synthetase [Escherichia coli] ^" 2725135 -gbt B08604:1 | (U70214) phosphatidate cytidylyltransferase [Escherichia coli] gb|AAC73286.l| (AE000127) CDP-diglyceride synthetase [Escherichia coli K12] dbj |BAA77850.l| (D83536) Phosphatidate cytidylyltransferase (EC 2.7.7.41)

[Ξscherichia coli] gb|AAG54477.1 | AΞ005193_7

(AE005193) CDP-diglyceride synthetase

[Escherichia coli 0157 :H7] SEQ ID n~β58 sp|Q47675|UPPS_EC0LI UNDΞCAPRENYL PYROPHOSPHATE

SYNTHETASE (UPP SYNTHETASE) (DI-TRANS-

POLY-CIS-DΞCAPRENYLCISTRANSFERASE)

Contig9 from (UNDΞCAPRENYL DIPHOSPHATE SYNTHASE) (UDS)

SEQ ID n° 8193 PL-1560.1 2725145 to m 793 pir] |F64741 conserved hypothetical protein bθl74

2725909 - Escherichia coli gb | AAC73285.1 | (AE000127) orf, hypothetical protein [Escherichia coli K12] gb|AAG54476.l|AE005193_6 (AE005193) orf, hypothetical protein [Escherichia coli 0157.-H7] SEQ ID n~057

Contig9 from gb|AAG54475.l|AE005l93_5 (AE005193) putative ATP-

SEQ ID n° 8194 PL-1559.1 2726124 to m 77? binding component of a transport system

2727320 [Escherichia coli θl57:H7] SEQ ID n~655

Contig9 from gb|AAK04071.l| (AE006235) Errf [Pasteurella

SEQ ID n° 8195 PL-3602.1 2727587 to 87% multocida]

2728144 SΞQ ID n-2801

TABLEAU II

sp|P29464|PYRH_ECOLI URIDYLATE KINASE (UK)

(URIDINE MONOPHOSPHATE KINASE) (UMP KINASE)

(SMBA PROTEIN) pir||B45269 uridine 5'- monophosphate kinase (EC 2.7.4.-) [validated] -

Escherichia coli dbj |BAA02598.l] (D13334) SmbA

[Escherichia coli] dbj | BAA05615.1 | (D26562)

Contig9 froπu

'mukB suppressor protein "smbA¹ [Escherichia

SEQ ID n° 8196 PL-1558.1 2728263 to m S53 coli] gb|AAB08600.l| (U70214) uridine 5'- 2728991 monophosphate (UMP) kinase [Escherichia coli] gb[AAC73282.l| (AE000126) uridylate kinase

[Ξscherichia coli KÏ21 dbj-|BAA77846. l| (D83536)

MukB suppressor protein. [Escherichia coli] gb|AAG54473.l|AE005193_3 (AE005193) uridylate kinase [Ξscherichia coli 0157 :H7] SΞQ ID n~S54 sp|P02997|ΞFTS_ECOLI ELONGATION FACTOR TS (EF- TS) pir||EFΞCS translation elongation factor EF Ts - Escherichia coli___emb| CAA23632.1 ( (V00343) elongation factor Ts [Escherichia coli] dbj |BAA05614.l| (D26562) 'elongation factor EF- Ts ' [Escherichia coli] gb| AB08599.1 | (U70214)

Contig9 from elongation factor EF-Ts [Escherichia coli] SEQ ID n^» 8197 PL-1557.1 2729146 to 823 gb|AAC73281.l( (AE000126) protein chain

2729997 elongation factor EF-Ts [Escherichia coli

K12] dbj |BAA77845.l| (D83536) Translation elongation factor TS . [Escherichia coli] gb(AAG54472.l|AE005193_2 (AE005193) protein chain elongation factor EF-Ts [Escherichia coli

0157 :H7] SEQ ID n~653

TABLEAU II

sp|P0235l|RS2_ECOLI 30S RIBOSOMAL PROTEIN S2 pir|-|R3EC2 ribosomal protein S2 [validated] -

Ξscherichia coli emb|CAA23631. il (V00343) ribosomal protein S2 [Escherichia coli] dbj |BAA05613.l| (D26562) ' ribosomal protein S2 '

Contig9 from

[Escherichia coli] gb | AB08598.1 | (U70214) SEQ ID n°-8-l-98r-Pirr-1556-.-l-~ 2730148 to m 923

^"ribosomal protein S2 [Escherichia coli]

2730873 gb|AAC73280. l| (AE000126) 30S ribosomal subunit protein S2 [Ξscherichia coli K12] gb|AAG54471.l|AE005193_l (AE005193) 30S ribosomal subunit protein S2 [EscherichïaTcoli^"

0157 :H7] SEQ ID n~θ52

Contig9 from SEQ ID n° 8199 PL-6039.1 2731065 to m No Hits found

2731232 #N/A sp|P10882|AMPM_SALTY METHIONINΞ AMINOPΞPTIDASΞ

Contig9 from (MAP) (PEPTIDASE M) pir||S12027 methionyl SEQ ID n° 8200 PL-1555.1 2731305 to 83% aminopeptidase (EC 3.4.11.18) - Salmonella

2732102 typhimurium emb |CAA39298. l| (X55778) peptidase

M [Salmonella typhimurium] SEQ ID n~651 sp | P27249 | GLND_ECOLI [PROTΞIN-PII]

URIDYLYLTRANSFERASE (PII URIDYLYL-TRANSFERASE)

(URIDYLYL REMOVING ENZYMΞ) (UTASΞ) pir | |G64740

Contig9 from uridylyltransferase (ΞC 2.7.7.59) - Escherichia SEQ ID n° 8201 PL-1554.1 2732240 to 77% coli gb|AAB08596.l| (U70214) PII uridylyl¬

2734888 transferase [Escherichia coli] gb| AAC73278.1 | (AE000126) protein PII; uridylyltransferase acts on regulator of glnA [Escherichia

TABLΞAU II

sp | P03948 | DAPDJ3COLI 2,3,4, 5-TETRAHYDROPYRIDINΞ-

2-CARBOXYLATE N-SUCCINYLTRANSFERASE

(TETRAHYDRODIPICOLINATΞ N-SUCCINYLTRANSFERASE)

(THP SUCCINYLTRANSFERASE)

(TETRAHYDROPICOLINATE SUCCINYLASE) pir] ( XNECSD

2,3,4,5- etrahydropyridine-2 -carboxylate N-

Contιg9 from succinyltrahsferase^~(EC ^{~ :} 2.3.1.117) - SEQ ID n° 8202 PL-1553.1 2735060 to 89% Escherichia coli dbj |BAA05610.l| (D26562)

2735884 ¹ tetrahydrodipicolinate N-succinyltransferase '

[Escherichia coli] gb |AAB08595.1 | (U70214) tetrahydrod±p±colinate N-succinyltransferase [Escherichia coli] gb|AAC73277. l|

(AEO00126) 2,3, 4, 5-tetrahydropyridine-2- carboxylate N-succinyltransferase

[Escherichia coli K12] SEQ ID n~β49 sp | P37048 | YAEH_ECOLI HYPOTHETICAL 15.1 KD

PROTEIN IN HTRA-DAPD INTERGENIC REGION pir| [S45230 yaeH protein - Ξscherichia coli dbj |BAA05609.l| (D26562) 'ORF' [Ξscherichia

Contig9 from coli] gb|AAB08593. l| (U70214) hypothetical SΞQ ID n° 8203 PL-6043.1 2736099 to 883

[Ξscherichia coli] gb|AAC73274.l( (AΞ000126)

2736485 putative structural protein [Escherichia coli

K12] gb|AAG54467.l|AΞ005192_9 (AΞ005192) putative structural protein [Escherichia coli

0157 :H7] #N/A

Contig9 from pir||S45108 hypothetical protein 2 - Erwinia

SEQ ID n° 8204 PL-3603.2 2736543 to m 763 carotovora emb| CAA55983. l| (X79474) ORF2

2736992 [Pectobacterium carotovorum] #N/A

Contig9 from gb|AAG43452.1 | AF188518_1 (AF188518) EmrB-like

SEQ ID n° 8205 PL-1552.2 2737363 to 373 protein SemB [Staphylococcus aureus]

2737965 #N/A sp|Q47417|YQCB_BR CA ΞXOENZYMΞ REGULATION

Contig9 from

REGULON ORFl pir | |S45107 hypothetical protein 1

SEQ ID n° 8206 PL-1551.1 2738457 to 683

- Ξrwinia carotovora emb | CAA55982.1 ] (X79474)

2739227

ORFl [Ξrwinia carotovora] SEQ ID n~647

TABLEAU II

sp|Q57152|YQCC_HAEIN HYPOTHETICAL PROTEIN HI1436

Contig9 from pιr| | 164171 hypothetical protein HI1436 - SΞQ ID n° 8207 PL-6045.1 2739229 to m 56% Haemophilus influenzae (strain Rd ^~~ 2739561 KW20) gb|AAC23085.l( u328^~22) conserved hypothetical protein [Haemophilus influenzae Rd] #N/A sp|P43526|SYDP_ECOLI SYD PROTEIN pir||A55944 syd protein - Escherichia coli âEfT|^'BA£θ^~7525 • 11

Contig9 from

(D38520) Syd protein [Escherichia coli] SEQ ID n° 8208 PL-3605.1 2740085 to m 653 gb|AAB40443.l| (U29581) GTG start [Escherichia

2740639 coli] gb|AAC75835.l| (AE000363) interacts with secY [Escherichia coli K12] ^~ SEQ ID n~280: sp|Q46920|YQCD_ECOLI HYPOTHETICAL 32.6 KD

PROTEIN IN SYD-SDAC INTERGENIC REGION

Contig9 from pir| |F65061 hypothetical protein b2794 - SEQ ID n° 8209 PL-1550.1 2740785 to 763 Escherichia coli (strain K-12) gb|AAB40444.l|

2741633 (U29581) ORF_o282 [Escherichia coli] gb|AAC75836.l| (AΞ000363) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~β46 sp|P37350|YGDH_ECOLI HYPOTHETICAL 51.0 KD

PROTEIN IN BARA-SDAC INTERGENIC REGION pir| |G65061 hypothetical protein b2795 -

Ξscherichia coli (strain K-12) gb| AAB40445. l|

Contig9 from

(U29581) TTG start; alternate gène name ygdH; SEQ ID n° 8210 PL-1549.1 2741756 to 833

ORF_o455 [Escherichia coli]

2743123 gb|AAC75837.l| (AE000363) orf, hypothetical protein [Escherichia coli K12] gb|AAG57909.l|AE005507_10 (AE005507) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~644

Contig9 from gb|AAG57912.l|AE005508_3 (AE005508) 5 ' -3 '

SEQ ID n° 8211 PL-1548.1 2743187 to 81% exonuclease [Escherichia coli 0157 :H7]

2743945 SEQ ID n~043

Contig9 from dbj |BAA25796.l| (D49826) LipD [Serratia

SEQ ID n° 8212 PL- 1547.1 2743942 to 71% marcescens]

2745318 SEQ ID n~842

TABLEAU II

SΞQ ID n^» 821

SΞQ ID n° 821

Contig9 from gb AAD49576Tl|AF141295_2 (AF141295) protease SEQ ID n° 8215 PL-3607.1 2748503 to m 423 inhibitor [Pectobacterium carotovorum subsp .

2748835 carotovorum] SEQ ID n~2804 Contig9 from pdb | 1AK | Alkaline Protease From Pseudomonas SEQ ID n° 8216^"TT-Fr5 471 2748962 to 633

Aeruginosa Ifo3080

2750404 ^a SEQ ID n~639

Sp|P32066|YGDE_ECOLI HYPOTHETICAL 41.9 KD

PROTEIN IN FUCR-GCVA INTERGΞNIC REGION (ORF3) pir] | 141067 hypothetical 41.9K protein (fucR-

Contig9 from gcvA intergenic région) - Escherichia SEQ ID n° 8217 PL-1543.1 2751589 to m 843 coli_ emb|CAA51815.l| (X73413) ORF3 [Escherichia

2752689 coli] gb|AAB40456.l| (U29581) alternate name

Orf2 of X73413 and U01030; ORF_f366

[Escherichia coli] gb| AAC75848.1 | (AΞ000364) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~β38 sp|P32065|YGDD_ΞCOLI HYPOTHETICAL 14.3 KD

PROTEIN IN FUCR-GCVA INTERGΞNIC REGION (ORF2) pir || 141066 hypothetical 14.3K protein (fucR- gcvA intergenic région) - Escherichia

Contig9 from coli emb|CAA51814.l] (X73413) 0RF2 [Escherichia SEQ ID n° 8218 PL-6047.1 2752682 to m 683 coli] gb|AAB40457.l| (U29581) alternate name

2753077 Orf3 of X73413; ORF_fl3l [Escherichia coli] gb|AAC75849.l| (AΞ000364) orf, hypothetical protein [Escherichia coli K12] gb|AAG57921.l|AE005508_12 (AE005508) orf, hypothetical protein [Escherichia coli 0157 :H7] #N/A

TABLEAU II

sp|P32064|GCVA_ECOLI GLYCINE CLEAVAGE SYSTEM

TRANSCRIPTIONAL ACTIVATOR _. (GCV OPERON

ACTIVATOR) pir || 141065 glycine cleavage system transcription activator - Ξscherichia coli emb|CAA51813.l| (X73413) glycine cleavage

Contig9 from activator protein [Escherichia coli]

SEQ ID n° 8219 PL-1542.1 2753138 To^" m 873 gb|AAC13742.l| (U0T03O ^"GcvA [Escherichia coli] 2754058 gb|AAB40458.l| (U29581) CG Site No. 28676

[Escherichia coli] gb|AAC75850.l| (AE000364) positive regulator of gcv operon [Escherichia coli K12] gb|AAG57922TXJAE005508_13 (AE005508) positive regulator of gcv operon [Escherichia coli 0157 :H7] SEQ ID n~837 pir| |F65063 hypothetical protein b2810 -

Escherichia coli (strain K-12) gb| AAB40460.l|

Contig9 from (U29581) ORF_o401 [Escherichia coli]

SEQ ID n° 8220 PL-1541.1 2754611 to p _ 69% gb[AAC75852.l| (AE000364) orf, hypothetical

2755864 protein [Ξscherichia coli K12] dbj |BAB21541.1 |

(AB055109) NifS-like cysteine sulfinate desulfinase [Ξscherichia coli] SEQ ID n~β36 sp|Q46926|YGDK_ECOLI HYPOTHETICAL 15.9 KD

PROTEIN IN GCVA-METZ INTERGΞNIC REGION (0147) pir| |G65063 hypothetical protein b2811 -

Contig9 from Ξscherichia coli (strain K-12) gb| AAB40461.l|

SEQ ID n° 8221 PL-3608.1 2755885 to 63% (U29581) ORF_O147 [Ξscherichia coli]

2756340 gb|AAC75853.l| (AΞ000364) orf, hypothetical protein [Ξscherichia coli K12] gb|AAG57925.l|AE005509_3 (AE005509) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~2805 sp|Q46927| GDL_ECOLI HYPOTHETICAL 28.6 KD

PROTEIN IN GCVA-MLTA INTERGENIC REGION

Contig9 from pir| |H65063 hypothetical protein b2812 -

SEQ ID n° 8222 PL-1540.1 2756343 to m 883 Escherichia coli (strain K-12) gb|AAB40462.l| 2757155 (U29581) ORF_f268 [Ξscherichia coli] gb|AAC75854.l| (AE000364) putative enzyme

[Escherichia coli K12] SEQ ID n~635

TABLEAU II

Contig9 from gb|AAB40463.l| (U29581) ORF_f432 [Escherichia SEQ ID n° 8223 PL-1539.1 2757204 to m 77? coli] 2758301 SEQ ID n~633

Contig9 from SEQ ID n° 8224 PL-6051.1 2758558 to m No Hits found

2758782 #N/A

Contig9 from SΞQ ID n° 8225 PL-6052.1 2759074 to p No Hits found

2759199 #N/A ref |NP_061700. l| conserved hypothetical protein

[Xylella fastidiosa] pir| |D82866~conserved

Contig9 from hypothetical protein XFa0045 [imported] - SEQ ID n° 8226 PL-6053.1 2759163 to 443

Xylella fastidiosa (strain 9a5c)

2759360 gb|AAF85613.l|AE003851_44 (AE003851) conserved hypothetical protein [Xylella fastidiosa] #N/A ref |NP_06l701.l| hypothetical protein [Xylella fastidiosa] pir|]E82866 hypothetical protein

Contig9 from

XFa0046 [imported] - Xylella fastidiosa SEQ ID n° 8227 PL-6055.1 2759357 to 71%

(strain 9a5c) gb|AAF85614. l| AΞ003851_45

2759497

(AΞ003851) hypothetical protein [Xylella fastidiosa] /

Contig9 from s | Q46929 | MIC_ECOLI N-ACETYLMURAMOYL-L-ALANINE

SEQ ID n° 8228 PL-153Î .1 2759575 to 843 AMIDASE AMIC PRECURSOR 2760819 SEQ ID n~832

TABLEAU II

sp|P08205|ARGA_ECOLI AMINO-ACID ACETYLTRANSFERASE (N-ACETYLGLUTAMATE SYNTHASE)

(AGS) (NAGS) pir| |χYECAA amino-acid

N-acetyltransferase (ΞC 2.3.1.1) - Ξscherichia coli emb|CAA68547.l| (Y00492) N-acetylglutamate synthase (AA l - 443) [Escherichia coli]

-Θon-t±g9—f-rom- gb|AAB404657l| ^" (U29581) N-acetylglutamate

SEQ ID n° 8229 PL-1537.1 2761064 to 873 synthase [Ξscherichia coli] gb| AAC75857.1 |

2762410

(AΞ000365) N-acetylglutamate synthase; amino acid acetyltransferase [Escherichia coli K12] ^"gb^"[AAG57929.l|AE005510_l (AE005510) N- acetylglutamate synthase; amino acid acetyltransferase [Escherichia coli

0157:H7] SEQ ID n~631

Contig9 from gb|AAB63525.l| (U12682) celfur protein SEQ ID n° 8230 PL-1535.1 2762642 to m 11% [Caenorhabditis elegans]

2769034 SEQ ID n~830 Contig9 from SEQ ID n° 8231 PL-3611.1 2769064 to m No Hits found

2769585 SEQ ID n~2808 Contig9 from SEQ ID n° 8232 PL-3612.1 2769634 to m No Hits found

2770155 SEQ ID n~2809 Contig9 from SEQ ID n° 8233 PL-3613.1 2770204 to No Hits found

2770725 SΞQ ID n~2810 Contig9 from SΞQ ID n° 8234 PL-3614.1 2770784 to No Hits found

2771314 SΞQ ID n~2811 Contig9 from SEQ ID n° 8235 PL-3615.1 2771373 to m No Hits found

2771894 SEQ ID n~2812 Contig9 from SEQ ID n° 8236 PL-3616.1 2771953 to m No Hits found

2772474 SEQ ID n~2813

TABLEAU II

Contig9 from SΞQ ID n° 8237 PL-3617.1 2772523 to No Hits found

2773044 SEQ ID n~2814 pir| |F82561 hemolysin secretion protein D XF2398

Contig9 from [imported] - Xylella fastidiosa SΞQ ID n° 8238 PL-1530.1 2773154 to 633 (strain 9a5c) gb| AAF85197. l| AE004049_2 = ^" 2774569 (AE004049) hemolysin secreTion protîeι^"n^" D

[Xylella fastidiosa] SEQ ID n~β26 pir| |E82561 toxin secretion ABC transporter ATP- binding protein XF2397 [imported] - Contig9 from_ Xylella fastidiosa—(strain 9a5c)

SEQ ID n° 8239 PL-1529.1 2774711 to m 773 gb|AAF85196.l|AE004049_l (AE004049) toxin

2776846 secretion ABC transporter ATP-binding protein

[Xylella fastidiosa] SEQ ID n~624 sp|P04993|EX5A_ECOLI EXODEOXYRIBONUCLEASE V ALPHA CHAIN (EXODEOXYRIBONUCLEASE V 67 KDA POLYPEPTIDE) pir| | CECXF exodeoxyribonuclease V

Contig9 from (EC 3.1.11.5) 67K chain - Escherichia coli SEQ ID n° 8240 PL-1528.1 2777712 to 68% gb|AAB40466.l| (U29581) exonuclease V alpha-

2779568 subunit [Escherichia coli] gb | AAC75858.1 | (AE000365) DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease [Ξscheriσhia coli K12] SΞQ ID n-823 sp|P08394|ΞX5B_BCOLI EXODEOXYRIBONUCLEASE V BETA

CHAIN (EXODEOXYRIBONUCLEASE V 135 KDA

POLYPEPTIDE) pir| |NCECX5 exodeoxyribonuclease V

(EC 3.1.11.5) 135K chain - Escherichia coli emb|CAA28250.l| (X04581) exonuclease V (AA 1-

Contig9 from

1180) [Escherichia coli] gb| AAB40467. l| SEQ ID n° 8241 PL-1527.1 2779565 to 733

(U29581) exonuclease V subunit [Escherichia

2783173 coli] gb|AAC75859.l| (AE000365) DNA helicase,

ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease [Escherichia coli

K12] gb|AAD56369.l|AF179304_l (AF179304)

RecB2l09 [Escherichia coli] SEQ ID n~β22

TABLEAU II

SEQ ID n° 8242 PL-1526.1

GAMMA CHAIN (EXODEOXYRIBONUCLΞASE V 125 KDA

POLYPEPTIDE) pir] |NCECXV exodeoxyribonuclease V (EC 3.1.11.5) 125K chain -^~ Escherichia coli ^~

Contig9 from emb|CAA27604.l| (X03966) recC protein (aa 1- SEQ ID n° 8243 PL-1525.1 2786077 to 74% 1122) [Escherichia coli] gb|AAB40469.l|

2789466 (U29581) exonuclease V subunit [Escherichia

—co-li] gb|AAC75861.l| (AE000366) DNA hel±Cérse, -

ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease [Escherichia coli

K12] SEQ ID n~θ20

Contig9 from SEQ ID n° 8244 PL-6060.1 2789459 to m No Hits found

2789836 #N/A Contig9 from SEQ ID n° 8245 PL-3619.2 2789827 to m No Hits found

2790312 #N/A gb|AAG57936.l|AE005511_4 (AE005511) prepilin

Contig9 from peptidase dépendent protein B [Escherichia coli SEQ ID n° 8246 PL-6062.2 2790318 to m 42% 0157:H7 EDL933] dbj |BAB37105.1 | (AP002563)

2790905 prepilin peptidase dépendent protein B

[Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG57937.l|AE005511_5 (AE005511) prepilin SEQ ID n° 8247 PL-3620.1 2791073 to 403 peptidase dépendent protein A [Escherichia coli

2791576 0157 :H7] SEQ ID n~2817 Contig9 from gb|AAG31734.l|AF264949_2 (AF264949) unknown SEQ ID n° 8248 PL-6064.1 2792068 to 33% [Erwinia amylovora] gb| AAG31738.1 | AF264951_2

2792400 (AF264951) unknown [Erwinia amylovora] #N/A Contig9 from gb|AAG31733.1 |AF264949_1 (AF264949) unknown SEQ ID n° 8249 PL-6065.1 2792397 to m 463 [Erwinia amylovora] gb| AAG31737.l| F264951_1

2792663 (AF264951) unknown [Erwinia amylovora] #N/A

TABLEAU II

pdb|lAX |A Chain A, Ξ. Coli Thymidylate Synthase

In Complex With Methotrexate (Mtx)

And 2 ' -Deoxyuridine 5 ' -Monophosphate (Dump) pdb|lAXW|B Chain B, Ξ. Coli Thymidylate Synthase

^' In Complex With Methotrexate (Mtx)

And 2 ' -Deoxyuridine 5 ' -Monophosphate (Dump) pdb|lTRG| Er Coli Thy dylate Synthase In

Symmetric Complex With Cb37l7 And 2'-

Deoxyuπdine 5 ' -Monophosphate (Dump) pdb | ITSD j A

Chain A, Thymidylate Synthase Complex With ' -

Contig9 from Deoxyuridine 5 ' -Monophosphate (Dump)

SEQ ID n° 8250 PL-1524.1 2792791 to m 913 And Folate Analog 1843u89 pdb | ITSD |B Chain B,

2793585 Thymidylate Synthase Complex With 2 ' -

Deoxyuridine 5 ' -Monophosphate (Dump)

And Folate Analog 1843u89 pdb|lDDU|A Chain A,

E . Coli Thymidylate Synthase In Complex With

Cb37l7 And 2 ' , 5 ' -Dideoxyuridine

(Ddurd) pdb|lDDϋ|B Chain B, Ξ. Coli Thymidylate

Synthase In Complex With Cb3717 And

2 ' , 5 ' -Dideoxyuridine (Ddurd) pdb | 1TDU| A Chain

A, E. Coli Thymidylate Synthase In Complex With

Cb3717 And 2 ' -Deoxyuridine (Durd) pdb|lTDU|B Chain B, E. Coli Thymidylate Synthase SEQ ID n~819 s | Q07293 | LGT_SALTY PROLIPOPROTEIN

DIACYLGLYCΞRYL TRANSFΞRASE pir| |A47354 probable

Contig9 from prolipoprotein glyceryl transferase - Salmonella SΞQ ID n° 8251 PL-1523.3 2793582 to m 783 typhimurium gb|AAA20896. l| (L13259)

2794457 prolipoprotein diacylglyceryl transferase

[Salmonella typhimurium] #N/A gb|AAG57940.l|AE005511_8 (AE005511) PTS System, enzyme I, transcriptional regulator (with

Contig9 from

NPR and NTR proteins) [Escherichia coli 0157 :H7

SEQ ID n° 8252 PL-1522.3 2794533 to 82%

EDL933] dbj |BAB37109.l| (AP002563) PTS System

2796779 transcriptional regulator enzyme I

[Ξscherichia coli 0157:H7] #N/A

TABLEAU II

sp | Q46930 | NUDH__ECOLI PROBABLE (DI) NUCLEOSIDE

POLYPHOSPHATE HYDROLASE (AP4A

PYROPHOSPHATASE) pir| |G65065 hypothetical

Contig9 from protein b2830 - Escherichia coli (strain K-12) SEQ ID n° 8253 PL-3622.1 2796789 to 843 gb|AAB40477.l| (U29581) ORF_fl76 [Escherichia

2797319 coli] gb|AAC75869.l| (AE000366) putative invasion protein [Escherichia- coli7K12] gb|AAG57941.l|AE005511_9 (AE005511) putative invasion protein [Escherichia coli 0157 :H7] SEQ ID n~2818 pir||S40584 hypothetical protein - Escherichia coli pir| |T45293 thiamin-bind±ng protein

Contig9 from precursor [imported] - Ξscherichia coli SEQ ID n° 8254 PL-1521.1 2797610 to 77% db |BAA0l339.l| (D10483) sfuA protein

2798623 homolog (PIR:A35108) [Ξscherichia coli] gb|AAA18833.1] (U09984) thiamin binding protein

[Escherichia coli] SEQ ID n~816 sp|P31549|THIP_ECOLI THIAMINE TRANSPORT SYSTEM

PERMEASE PROTEIN THIP pir| |C64728 probable

Contig9 from membrane protem yabK - Escherichia coli SΞQ ID n° 8255 PL-1520.1 2798599 to p 83^! gb|AAC73l78.l| (AΞ000117) putative transport

2800209 system permease protein [Ξscherichia coli K12] SΞQ ID n~S15

Contig9 from gb|AAG54370.l|AΞ005183_7 (AΞ005183) putative ATP SEQ ID n° 8256 PL-1519.1 2800196 to p 60% binding component of a transport system

2800903 [Escherichia coli 0157 :H7] SEQ ID n~θl3 Contig9 from gb|AAG43149.l|AF063187_l (AF063187) DNA SEQ ID n° 8257 PL-6069.1 2801169 to p 52% polymerase II [Pseudomonas fluorescens]

2801363 #N/A sp|P23852|HEPA_ECOLI RNA POLYMERASE ASSOCIATED

PROTEIN (ATP-DEPΞNDΞNT HELICASE HEPA) pir| |C64727 probable ATP-dependent helicase hepA

Contig9 from

- Escherichia coli gb|AAC73170.1] (AE000116) SEQ ID n° 8258 PL-1518.1 2801561 to p 883 probable ATP-dependent RNA helicase [Escherichia

2804473 coli K12] gb|AAG54363.l|AE005182_12

(AE005182) Z0067 gène product [Escherichia coli

0157 :H7] SEQ ID n~612

TABLEAU II

sp|P39219|RLUA_ECOLI RIBOSOMAL LARGE SUBUNIT

PSEUDOURIDINΞ_ SYNTHASE A (PSEUDOURIDYLATE

Contig9 from

SYNTHASE) (URACIL HYDROLYASE) pir | |B64727 yabO

SEQ ID n° 8259 PL--15-1-7-.-1 2-8-045-70 -to- - 803 protein - Escherichia coli gb|AAC73169.l| ~

2805220 (AEO00116) pseudouridylate synthase [Escherichia

SEQ ID n° 8260 PL-

sp|P31554|0STA_EC0LI ORGANIC SOLVENT TOLERANCE

PROTΞIN—PRECURSOR pir| |F64726 organic solvent

Contig9 from tolérance protein precursor - Ξscherichia coli SEQ ID n° 8261 PL-1515.1 2806587 to p 79? gb|AAC73165. l| (AE000115) organic solvent

2808911 tolérance [Escherichia coli K12] dbj |BAA34130.l| (AB013134) ostA/imp [Ξscherichia coli] SEQ ID n~θ09 sp|P21202 |SURA_ECOLI SURVIVAL PROTEIN SURA

PRECURSOR (PEPTIDYL-PROLYL CIS-TRANS

ISOMERASE SURA) (PPIASE) (ROTAMASE C)

Contιg9 from p r| |E64726 probable peptidylprolyl isomerase SEQ ID n° 8262 PL-1514.1 2808981 to 79% (ΞC 5.2.1.8) surA precursor -

2810282 Escherichia coli gb| AAC73164.l| (AΞ000115) survival protein [Escherichia coli K12] gb|AAG54358.l|AΞ005182_7 (AE005182) survival protein [Escherichia coli 0157 :H7] SEQ ID n~β08 sp|P19624|PDXA_ECOLI PYRIDOXAL PHOSPHATE

BIOSYNTHΞTIC PROTEIN PDXA pir] | BVECXA pyridoxal

ContigS from phosphate biosynthetic protein pdxA - SEQ ID n° 8263 PL-1513.1 2810260 to 793

Escherichia coli gb| AAA24305.1 | (M68521) pdxA

2811279

[Escherichia coli] gb|AAC73163.ι| (AΞ000115) pyridoxine biosynthesis [Escherichia coli K12] SEQ ID n~607

TABLEAU II

sp | 06992 | KSGA_ECOLI DIMΞTHYLADENOSINE

TRANSFERASE (S-ADENOSYLMETHIONINE-6- ' ,

N'-ADENOSYL(RRNA) DIMETHYLTRANSFERASE) (16S RRNA

DIMETHYLASE) (HIGH LEVEL KASUGAMYCIN RESISTANCE

PROTEIN KSGA) (KASUGAMYCIN

DIMETHYLTRANSFERASE) pir | (XYECRO rRNA (adenine-

N6,N6-) -dimethyltransfeτase (EC 27I7Ï.-) -

Escherichia coli emb[CAA28417.l| (X04711) put.

Contig9 from

16S rRNA methyltransferase (ksgA) (AA 1-273)

SEQ ID n° 8264 PL-1512.1 2811272 to 89%

[Escherichia coli] gb| AAA24049.1 | (M11054)

2812090 methyltransferase~(ksgA)^~~ [Escherichia coli] dbj |BAA01327.l| (D10483) rRNA (adenosine-N6,N6-) dimethyltransferase [Escherichia coli] gb|AAC7 162.l| (AE000115) S- adenosylmethionine-6-N' ,N' -adenosyl (rRNA) dimethyltransferase [Escherichia coli K12] prf | | 1112172A methyltransferase [Escherichia coli] SEQ ID n~S06 sp|P05636|APAG_ECOLI APAG PROTEIN pir] |BVECAG apaG protein - Escherichia coli emb|CAA28418. l|

(X04711) URF (apaG) (AA 1-375) [Ξscherichia

Contig9 from coli] dbj |BAA01326.l| (D10483) apaG protein SΞQ ID n° 8265 PL-6070.1 2812103 to p 83^!

[Ξscherichia coli] gb|AAC73161.1 | (AE000115)

2812480 orf, hypothetical protein [Escherichia coli K12] gb|AAG54355.l|AΞ005182_4 (AE005182) orf, hypothetical protein [Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG54354.l|AΞ005182_3 (AΞ005182) diadenosine SEQ ID n° 8266 PL-1511.1 2812483 to p 793 tetraphosphatase [Escherichia coli 0157 :H7]

2813310 SEQ ID n~605

sp|P00379|DYR_ECOLI DIHYDROFOLATE REDUCTASE pir| |RDECD dihydrofolate reductase (EC 1.5.1.3) type I - Escherichia coli pdb | IDDR |B Chain B,

Molécule: Dihydrofolate Reductase (E.C.1.5.1.3)

Complexed With Methotrexate And Urea pdb|lDDS|B Chain B, Molécule: Dihydrofolate

Reductase (E.C.1.5.1.3) Complexed

With Methotrexate pdb | IDD | A Chain A, Molécule:

Contig9 from

Dihydrofolate Reductase (E.C.1.5.1.3) Complexed SEQ ID n° 8267 PL-3623.1 2813354 to 853

With Methotrexate And Urea pdb|lDDS|A Chain A, _ 2813839

^" Molécule: Dihydrofolate Reductase (E.CIT5.1.3)

Complexed With Methotrexate gb|AAA87976.l| (J01609) dihydrofolate reductase

[Escherichia coli] dbj |BAA01324.1 | (D10483) dehydrofolate reductase, type I [Escherichia coli] gb|AAC73159.l| (AE000115) dihydrofolate reductase type I; trimethoprim résistance

[Escherichia coli K12] SEQ ID n~2819 pir||F83306 hypothetical protein PA2710

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 8268 PL-1510.1 2814019 to 70% (strain PAOl) gb| AAG06098.1 | E004699_3

2814633 (AE004699) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~604 s | P14846 | CARB_SALTY CARBAMOYL-PHOSPHATE

Contigs from SYNTHASE LARGE CHAIN (CARBAMOYL-PHOSPHATE SEQ ID n° 8269 PL-1509.1 2814730 to m 95% SYNTHETASE AMMONIA CHAIN) gb| AAB39256.1 |

2817954 (U81260) carbamoylphosphate synthetase large subunit [Salmonella typhimurium] SEQ ID n~802

s | P00907 | CARA_ΞCOLI CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN -(-CARBAMOYL-PHOSPHATE SYNTHETASB GLUTAMINE CHAIN) pir| | SYECCS carbamoyi-phosphate synthase (glutamine- hydrolyzing) (EC 6.3.5.5) small chain [validated] - Escherichia coli dbj |BAA01310. l| (D10483) carËâ ôyr- hosphate ^"synthase small chain [Escherichia coli]

Contig9 from gb|AAA23538.l| (J01597) carbamoyi-phosphate

SΞQ ID n° 8270 PL-1508.2 2817970 to 863 synthetase subunit A (ttg start codon)

2819133 [EscherieJhTâ^~coïιT^" gb|AAC73143. l| (AE000113) carbamoyi-phosphate synthetase, glutamine

(small) subunit [Escherichia coli

K12] gb|AAG54334.l|AE005180_l (AΞ005180) carbamoyi-phosphate synthetase, glutamine

(small) subunit [Ξscherichia coli

0157.-H7 ΞDL933] . dbj |BAB33458.11 (AP002550) carbamoyi-phosphate synthetase small subunit

[Escherichia coli 0157 :H7] #N/A

sp | P04036 | DAPB_ECOLI DIHYDRODIPICOLINATΞ REDUCTASE- (DHPR) pir| | RDECPD— dihydrodipicolinate reductase (EC 1.3.1.26) -_

Ξscherichia coli pdb|lARZ|D Chain D,

Ξscherichia Coli Dihydrodipicolinate Reductase

In Complex With Nadh And 2 , 6 Pyridine

Dicarboxylate ^"pdb|lARZ|B ChaιnTB~E^""scHerichia

Coli Dihydrodipicolinate Reductase In Complex

With Nadh And 2 , 6 Pyridine Dicarboxylate pdb|lARZ|c Chain C, Escherichia Coli

Dihydrodipicolinate Reductase Tn Complex

Contig9 from

With Nadh And 2,6 Pyridine Dicarboxylate SEQ ID n° 8271 PL-1507.2 2819569 to m 883 pdb|lDIH| Mol_id: 1; Molécule:

2820390

Dihydrodipicolinate Reductase; Chain: Null;

Ec : 1.3.1.26; Engineered: Yes pdb | IDR |

Escherichia Coli DhprNHDH COMPLEX pdb|lDRU|

Escherichia Coli DhprNADH COMPLEX pdb|lDRV|

Escherichia Coli DhprACNADH COMPLEX pdb|lARZ|A

Chain A, Escherichia Coli Dihydrodipicolinate

Reductase In Complex With Nadh And

2,6 Pyridine Dicarboxylate gb ] AAA23666.l|

(M10611) dihydropicolinate reductase

[Escherichia coli] dbj |BAA01309.l] (D10483) dehydrodipicolinate reductase [Escherichia coli] /A

Contig9 from

SΞQ ID n^» 8272 PL-6073.1 2820660 to m No Hits found

2820821 #N/A sp|P43420|MTB6_BACSP MODIFICATION MΞTHYLASΞ BSP6I (CYTOSINB-SPECIFIC METHYLTRANSFΞRASE BSP6I) (M.BSP6I) pir||l40138 site-specific DNA-

Contig9 from methyltransferase (cytosine-specific) (EC SEQ ID n^» 8273 PL-1506.1 2821161 to 223 2.1.1.73) - Bacillus sp emb [CAA57293.1 [

2822300 (X81638) site-specific DNA-methyltransferase (cytosine-specific) [Bacillus sp.] prf | |2115268B methyltransferase Bsp6IM [Bacillus sp . ] SΞQ ID n~399

Contig9 from SEQ ID n° 8274 PL-1505.1 2822293 to No Hits found - ~

2823288 SEQ ID n~598 ContigS from SEQ ID n° 8275 PL-1504.1 2823343 to

2824911

Contig9 from gb|AAK01530.l| (AF241171) hypothetical prote SEQ ID n° 8276 PL-1503.1 2824896 to 113 [Pseudomonas aeruginosa]

2825927 SΞQ ID n~396 sp|P33997|ALPA_ΞCOLI PROPHAGE CP4-57 REGULATORY

PROTEIN ALPA pir| |B65041 prophage cp4-57 regulatory protein AlpA - Escherichia coli

Contig9 from

(strain K-12) gb|AAA18418.1 | (U03737) AlpA SEQ ID n° 8277 PL-6078.1 2826089 to 673

[Escherichia coli] gb|AAA79793.1 | (U36840) AlpA

2826202

[Escherichia coli] gb|AAC75672.1 | (AE000348) prophage CP4-57 regulatory protein alpA

[Escherichia coli K12] #N/A

Contig9 from gb|AAC26596.l| (U83995) putative protease SEQ ID n° 8278 PL-6079.1 2826265 to 333 [Porphyromonas gingivalis]

2826528 #N/A sp|P2 565 |LYTB_ECOLI LYTB PROTEIN pir|| E0403 lytB protein - Ξscherichia coli emb |CAA38707. l|

(X54945) ORF 2 [Fscherichia coli] dbj |BAA01307.1 | (D10483) hypothetical 34.8K

Contig9 from protein (PIR.-JE0403) [Ξscherichia coli] SEQ ID n° 8279 PL-1502.1 2826541 to 833 gb|AAC73140.l| (AΞ000113) control of stringent

2827494 response; involved in penicillin tolérance [Escherichia coli K12] gb|AAG54331.l|AE005179_8 (AE005179) control of stringent response; involved in penicillin tolérance [Escherichia coli 0157 :H7] SEQ ID n~595

Contig9 from gb|AAF19641.l|AF201388_3 (AF201388) FkbB-type SEQ ID n° 8280 PL-3624.1 2827475 to m 71? peptidyl-propyl cis-trans isomerase

2827945 [Klebsiella pneumoniae] SΞQ ID n~2820

Contig9 from gb|AAG54329.l|AΞ005179_6 (AE005179) SEQ ID n° 8281 PL-3625.1 2827951 to 803 prolipoprotein signal peptidase (SPase II)

2828454 [Escherichia coli 0157 :H7] SEQ ID n~2821 sp|P00956|SYI_ECOLI ISOLΞUCYL-TRNA SYNTHETASE

(ISOLΞUCINΞ--TRNA LIGASE) (ILERS) pir]|SYECIT

Contig9 from isoleucine--tRNA ligase (EC 6.1.1.5) - -SΞQ-ID n° 8282 PL-1501.1 2828454—to ΠL. _8S

Escherichia coli^{" "~}gb|AAC73137.^"l| (AEO00113 )

2831267 isoleucine tRNA synthetase [Escherichia coli

K12] SEQ ID n~594 sp|P0839l|RIBF_ΞCOLI RIBOFLAVIN BIOSYNTHESIS

PROTEIN RIBF fINCLUDΞST RIBOFLAVIN KINASΞ

(FLAVOKINASΞ) ; FMN ADENYLYLTRANSFΞRASE (FAD

PYROPHOSPHORYLASE) (FAD SYNTHETASE) ]

Contig9 from pir| IQQECIL conserved hypothetical protein, SΞQ ID n° 8283 PL-1500.1 2831292 to m 78% 34.6K (rpsT-ileS intergenic région)

2832236

Escherichia coli gb|AAC73136.l| (AE000113) putative regulator [Escherichia coli K12] gb|AAG54327.l|AE005179_4 (AE005179) putative regulator [Escherichia coli 0157 :H7] SEQ ID n~S93 sp[P02378 |RS20_ECOLI 30S RIBOSOMAL PROTEIN S20 pir| |R3EC20 ribosomal protein S20/L26

[validated] - Escherichia coli dbj |BAA01302.l|

(D10483) ribosomal protein S20 [Escherichia

Contig9 from coli] emb|CAA27968.l| (X04382) ribosomal SEQ ID n° 8284 PL-6082.1 2832587 to 833 protein S20 [Escherichia coli] gb|AAC73134.l|

2832850 (AEO00113) 3OS ribosomal subunit protein S20

[Escherichia coli K12] gb|AAG54325.l|AE005179_2 (AE005179) 30S ribosomal subunit protein Ξ20 [Ξscherichia coli

0157 :H7] #N/A pir| |QQEC3R transcription activator nhaR -

Contig9 from

Escherichia coli gb|AAC73131.l| (AE000112)

SEQ ID n° 8285 PL-1499.1 2832921 to 813 transcriptional activator of nhaA [Escherichia

2833835 coli K12] SEQ ID n~590

pir| |B8 177 Na+/H+ antiporter protem VC1627 [imported] - Vibrio cholerae (group .

Contig9 from 01 Strain N16961) gb| AAC33562.l| (AF051158)

SEQ ID n° 8286 PL-1498.1 2834059 to 71? sodium-proton antiporter affecting protein

2835225 [Vibrio cholerae] gb| AAF94778.1 |

(AEO04240) Na+/H+ antiporter protein [Vibrio cholerae]^{" "}SEQ ID n~389

ContigS from SEQ ID n° 8287 PL-6083.1 2835474 to m No Hits found

2835899 #N/A sp|P 0739|PTBA_BACSU PTS SYSTEM, BETA^GLUCOSIDΞS

SPΞCIFIC IIABC COMPONBNT (ΞIIABC-BGL)

Contig9 from (BBTA-GLUCOSIDES-PERMEASE IIABC COMPONENT) SΞQ ID n° 8288 PL-1496.2 2836340 to m 593 (PHOSPHOTRANSFERASE ENZYME II, ABC COMPONENT)

2838187 (EII-BGL) pir] | 140406 beta-glucoside permease -

Bacillus subtilis emb| CAA84286.l| (Z34526) beta glucoside permease [Bacillus subtilis] #N/A sp|P39805|LICT__BACSU TRANSCRIPTION

Contig9 from ANTITERMINATOR LICT pir||S47216 transcription SEQ ID n° 8289 PL-1495.1 2838417 to m 53% antiterminator licT - Bacillus subtilis

2839271 emb|CAA82194.l| (Z28340) antiterminator

[Bacillus subtilis] SΞQ ID n~586 sp|P26207|PTBA_ERWCH PTS SYSTEM, BETA-GLUCOSIDES

SPECIFIC IIABC COMPONENT (EIIABC-BGL)

(BETA-GLUCOSIDES-PERMEASE IIABC COMPONENT)

ContigS from (PHOSPHOTRANSFΞRASE ENZYMΞ II, ABC COMPONENT) SEQ ID n° 8230 PL-1494.1 2839844 to 69% (EII-BGL) pir| |B42603 beta-glucoside-specific

2841286 phosphotransferase system-dépendent permease - Erwinia chrysanthemi gb|AAA24814.1 |

(M81772) beta-glucoside permease [Pectobacterium chrysanthemi] SEQ ID n~585

Contig9 from gb|AAG46031.l|AF309637_l (AF309637) 6-phθSpho-

SEQ ID n° 8291 PL-1493.1 2841362 to 82% beta-glucosidase-like protein [Leishmania

2842783 infantum] SEQ ID n~384

Contigθ from gb|AAG60975.l]AF322013_94 (AF322013) ID668 SEQ ID n° 8292 PL-1492.1 2842812 to 433 [Bradyrhizobium japonicum]

2844071 SEQ ID n~383

Contig9 from gb]AAG54315.l|AE005178_5 (AΞ005178) chaperone SEQ ID n° 8293 PL-1491.1 2844168 to m 91% with DnaK; heat shock protein [Ξscherichia

2845286 COli 0157:H7] SEQ ID n~382

^~'^"Contig9^" from sp|Q56073|DNAK_SALTY DNAK^""PROTEIN -(HEAT SHOCK SΞQ ID n° 8294 PL-1489.1 2845400 to 943 PROTEIN 70) (HSP70) gb | AAB02910.1 | (U58360)

2847310 DnaK [Salmonella typhimurium] SΞQ ID n~379 sp | 28695 | YAAH_ECOLI HYPOTHETICAL 20.1 KD

PROTEIN-IN-MOG-ΗTGA INTERGENIC REGION (ORF5) pir| |E56688 protein yaaH - Escherichia coli

Contig9 from emb|CAA4793l.l| (X67700) ORF5 [Escherichia coli] SEQ ID n° 8295 PL-3628.1 2847740 to p 78% gb|AAC73121.l| (AE000111) orf, hypothetical

2848309 protein [Escherichia coli K12] gb|AAG54310.l|AE005177_10 (AE005177) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~2822 pir| |E82181 aldose 1-epimerase VC1594 [imported]

Contig9 from

- Vibrio cholerae (group 01 strain SΞQ ID n° 8236 PL-1487.1 2848387 to m 643

N16961) gb|AAF94748.l| (AE004236) aldose 1-

284S448 epimerase [ ibrio cholerae] SEQ ID n~577 pir||F82181 galactokinase VC1595 [imported] -

ContigS from

Vibrio cholerae (group 01 strain SΞQ ID n° 8237 PL-1486.1 2849481 to m 743

N16961) gb|AAF94749.l| (AE004236) galactokinase

2850671

[Vibrio cholerae] SEQ ID n~376 pir] |G82181 galactose-1-phosphate

Contig9 from uridylyltransferase VC1596 [imported] - SEQ ID n° 8298 PL-1485.1 2850664 to m 84% Vibrio cholerae (group 01 strain N16961)

2851737 gb|AAF94750.l| (AE004236) galactose-1-phosphate uridylyltransferase [Vibrio cholerae] SEQ ID n~375 ref |NP_066722.l| hypothetical protein

Contig9 from

[Agrobacterium rhizogenes] dbj |BAB16260.1 [ SEQ ID n° 8299 PL-1484.2 2852146 to m 61%

(AP002086) hypothetical protein [Agrobacterium

2853624 rhizogenes] #N/A

Contig9 from gb|AAC26596.l| (U83995) putative protease SEQ ID n° 8300 PL-1483.2 2853564 to 593 [Porphyromonas gingivalis]

2854448 #N/A ref |NP_066722.1 | hypothetical protein

Contig9 from

[Agrobacterium rhizogenes] dbj |BAB16260.1 | SEQ ID n° 8301 PL-1482.1 2854436 to 453

(AP002086) hypothetical protein [Agrobacterium _ - 2855377 rhizogeriesj SEQ ID n~372 ref |NP_066721.1 | similar to orf300 gène (putative

AAA-family ATPase gène) in

Contig9 from

Escherichia coli [Agrobacterium rhizogenes] SEQ ID n° 8302 PL-1481.1 2855383 to m 683 dbj |BAB16259.l| (AP002086)—similar to orf300

2856489 gène (putative AAA-family ATPase gène) in Escherichia coli [Agrobacterium rhizogenes] SEQ ID n~37l sp|P42517|CHMU_ΞRWHΞ MONOFUNCTIONAL CHORISMATΞ

Contig9 from MUTASΞ PRΞCURSOR (CM-F) pir | | A40607 SΞQ ID n° 8303 PL-3629.1 2856925 to m 553 monofunctional chorismate mutase AroQ - Ξrwinia

2857485 herbicola gb[AAA73360.l| (M95628) chorismate mutase [Erwinia herbicola] SEQ ID n~2823 sp|P28694|MOG_ECOLI MOLYBDOPTERIN BIOSYNTHESIS

MOG PROTEIN pir| |B56688 molybdopterin biosynthesis protein mog - Escherichia coli emb|CAA47930.l| (X67700) ORFl [Ξscherichia coli]

Contig9 from gb|AAC73120.l| (AE000111) required for the SEQ ID n° 8304 PL-3630.1 2857623 to m 90% efficient incorporation of molybdate

2858198 into molybdoproteins [Escherichia coli K12] gb|AAG54309.l|AΞ005177__9 (AE005177) required for the efficient incorporation of molybdate into molybdoproteins [Escherichia coli 0157 :H7] SEQ ID n~2825

sp|P30148| ALB_ECOLI TRANSALDOLASE B pir||S40535 transaldolase (EC 2.2.1.2) B - Escherichia coli dbj |BAA01290.l| (D10483) transaldolase homolog (SWISS:P15019) [Escherichia coli] gb|AAC73119.l| (AEOOOlll) transaldolase B

[Escherichia coli K12] gb [AAB4702 .1 | (S80045)

-ContigS from

^"transaldolase B, D-sedoheptulose~7-—

SEQ ID n° 8305 PL- 1480.1 2858280 to m 85% phosphate : D-glyceraldehyde-3 -phosphate 2859233 dihydroxyacetone transferase {EC 2.2.1.2}

[Escherichia coli, K-12, Peptide, 317 ââ]^~ dbj |BAA21822.l| (D13161) transaldolase^"

[Escherichia coli] gb|AAG54308.l|AE005177_8

(AEO05177) transaldolase B [Ξscherichia coli

0157 :H7] SΞQ ID n~370 pιr| |H81390 probable intégral membrane protein

Contig9 from Cj 0461c [imported] - Campylobacter SEQ ID n° 8306 PL-1479.1 2859957 to 41% _ jejuni (strain NCTC 11168) emb|CAB75099.l|

2861168 (AL139075) putative intégral membrane protein

[Campylobacter jejuni] SEQ ID n~S68 sp|P11288 |YAAA_ECOLI PROTEIN YAAA pιr||Q3ECTC

Contig9 from yaaA protein - Escherichia coli dbj |BAA0128S. l| SEQ ID n° 8307 PL-1478.1 2861669 to 703 (D10483) Hypothetical protein 126: PIR:Q3ECTC

2862445 [Ξscherichia coli] gb| AAC73117.l| (AEOOOlll) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~S67 sp|P27735|THRC_SERMA THREONINE SYNTHASE pir| |S16043 threonine synthase (EC 4.2.99.2) -

Contig9 from

Serratia marcescens emb|CAA43214. l| (X60821) SEQ ID n° 8308 PL-1477.1 2862496 to m 873 threonine synthase [Serratia marcescens]

2863794 dbj |BAA01222.l| (D10387) threonine synthase

[Serratia marcescens] SEQ ID n~366 sp]P27722 |KHSE_SERMA HOMOSERINE KINASE (HK) pir| |C47057 homoserine kinase (EC 2.7.1.39) -

Contig9 from

Serratia marcescens emb| CAA43213. l| (X60821) SEQ ID n° 8309 PL-1476.1 2863798 to m 823 homoserine kinase [Serratia marcescens]

2864727 dbπ |BAA3848 .1 | (D10387) homoserine kinase

[Serratia marcescens] SEQ ID n~565

Contig9 from dbj ]BAA38477.l| (D10386) aspartokinase I- SEQ ID n° 8310 PL-1475.1 2864730 to m 86% homoserine dehydrogenase I [Serratia

2867189 marcescens] SEQ ID n~564 sp|P03026|ARCA_ΞCOLI AEROBIC RΞSPIRATION CONTROL

PROTΞIN ARCA (DYE RESISTANCΞ PROTΞIN) pir| | JYΞCR dye résistance protein - Ξscherichia coli gb|AAA23718^"". l| ^~(M10044) dye [Escherichia coli] gb|AAA97297.l| (U14003) alternate gène

Co SEQ ID n° 8311 PL-1474.1 2

and CpxA) [Escherichia coli K12] gb|AAG59581.l|AE005671_5 (AE005671) négative response regulator of gènes in aérobic pathways, (sensors, ArcB and CpxA) [Escherichia coli 0157 :H7] SEQ ID n~S63

Sp|P08367|CREA_ECOLI CREA PROTEIN pir||QQECFl creA protein - Ξscherichia coli gb|AAA24373.1 |

(M13608) 17 kd protein [Escherichia coli]

Contig9 from gb|AAA97293.1] (U14003) creA [Escherichia coli] SEQ ID n° 8312 PL-3633.1 2868780 to m 823 gb|AAC77350.l| (AE000510) orf , hypothetical

2869265 protein [Ξscherichia coli K12] gb[AAG59577.l|AΞ005671_l (AE005671) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~2826 sp|P27292 |ROB_ECOLI RIGHT ORIGIN-BINDING PROTΞIN pir| |JU0158 right oriC-binding protein - Ξscherichia coli gb| AA24569. l| (M97495) right

Contig9 from origin-binding protein [Ξscherichia coli]

SEQ ID n° 8313 PL-1473.1 2869649 to 72% gb|AAA97292.l| (U14003) rob [Escherichia coli]

2870524 gb|AAC77349.l| (AE000509) right origin-binding protein [Escherichia coli K12] gb|AAG59576.l|AE005670_9 (AE005670) right origin- binding protein [Escherichia coli 0157 :H7] SEQ ID n~362

pir| |S56619 gpmB protein - Escherichia coli

Contig9 from gb|AAA97291.l| (U14003) Kenn Rudd identifies as SEQ ID n° 8314 PL-1472.1 2870521 to m 853 gpmB [Escherichia coli] gb|AAC77348. l|

2871168 (AEO 00509) phosphoglyceromutase 2 [Escherichia coli K12] SEQ ID n~361

Contig9 from

— -gb|AAG59574.l|AE005670_7 (AE00-56-7-0-)—©r-f-

SΞQ ID n° 8315 PL-3634.1 2871223 to 643 hypothetical protein [Ξscherichia coli 0157.-H7]

2871753 SEQ ID n~2827 sp|P39439|TRPR_ΞNTAΞ TRP OPΞRON REPRESSOR

Contig9 from pir| |S45254 trp operon repressor - Enterobacter SEQ-.ID n° 8316 PL-6091.1 2871789 to m 7.6% aerogenes gb | AAC368S2.11 (L 65 2^") tryptophan

2872109 repressor [Enterobacter aerogenes] #N/A pir||S56616 soluble lytic transglycosylase -

Escherichia coli pir] ]QQECW1 soluble lytic transglycosylase (EC 3.2.1.-) precursor - Escherichia coli gb |AAA97288.1 |

Contig9 from (U14003) soluble lytic transglycosylase SEQ ID n° 8317 PL-1471.1 2872169 to m 693 [Escherichia coli] gb| AC77345.l| (AΞ000509)

2874109 soluble lytic murein transglycosylase

[Escherichia coli K12] gb|AAG59572.l|AE005670_5 (AΞ005670) soluble lytic murein transglycosylase [Escherichia coli

0157 :H7] SEQ ID n~360

ContigS from gb|AAK02509.l| (AEO 06078) unknown [Pasteurella SEQ ID n° 8318 PL-1470.1 2874582 to 903 multocida]

2876249 SEQ ID n~359 pir| |H72342 ABC transporter, ATP-binding protein

Contig9 from - Thermotoga maritima (strain MSB8) SΞQ ID n° 8319 PL-1469.1 2876288 to m 46% gb|AAD35787.l|AΞ001742_2 (AΞ001742) ABC

2877028 transporter, ATP-binding protein [Thermotoga maritima] SEQ ID n~557 pir| |S56614 transcription regulator nadR -

Contig9 from Escherichia coli gb| AA97286.l| (U14003) nadR SEQ ID n° 8320 PL-1468.1 2877709 to m 853 [Escherichia coli] gb| AAC77343.1 | (AΞ000509)

2878965 probable nadAB transcriptional regulator

[Escherichia coli K12] SEQ ID n~S56

sp|P2 554|RADA_ECOLI DNA REPAIR PROTEIN RADA (DNA REPAIR PROTEIN SMS) pir | | JC1417 DNA repair protein sms - Escherichia coli gb| AAA97285.l| Con-t-ig-9-from - -

(U14003) sms [Escherichia coli] emb|CAA44856.l|

SEQ ID n° 8321 PL-1467.1 2878958 to m 963 (X63155) sms [Escherichia coli] gb|AAC44380.l|

2880340 (U59449) RadA [Escherichia coli] gb|AAC7734 . l|

(AE0005O3) probable ATP-dependent protease

[Escherichia coli K12] SEQ ID n~355 sp|P06862|SERB_ECOLI PHOSPHOSERINE PHOSPHATASE

(PSP) (O-PHOSPHOSΞRINΞ PHOSPHOHYDROLAS )

(PSPASΞ) ^" pir| | PAECS phosphoserine phosphatase

Contig9 from (EC 3.1.3.3) - Escherichia coli emb | CAA26852. l] SEQ ID n° 8322 PL-1466.1 2880487 to m 82% (X03046) phosphoserine phosphatase (EC 3.1.3.3)

2881464 [Escherichia coli] gb|AAA97284.l| (U14003) phosphoserine phosphatase [Escherichia coli] gb|AAC77341.l| (AΞ000509) 3 -phosphoserine

_ phosphatase [Escherichia coli K12] SEQ ID n~554

Contig9 from gb|AAG59567.l|AΞ005669_ll (AE005669) putative SEQ ID n° 8323 PL-1465.1 2881580 to 643 lipoate-protein ligase A [Escherichia coli

2882224 0157 :H7] SEQ ID n~353 pir| |F82543 outer membrane hemolysin activator protein XF2550 [imported] - Xylella

Contig9 from fastidiosa (strain 9a5c) SEQ ID n° 8324 PL-1464.1 2882961 to 573 gb|AAF85347.l|AE004062_2 (AΞ004062) outer

2884652 membrane hemolysin activator protein [Xylella fastidiosa] SEQ ID n~352 pir||C83339 hypothetical protein PA2462

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 8325 PL-1463.3 2884711 to p 29% (strain PAOl) gb | AAG05850.1 |AE004573_10

2898459 (AE004673) hypothetical protein [Pseudomonas aeruginosa] #N/A pir| |A82955 hypothetical protein PA5527

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 8326 PL-6677.1 2898468 to p 563 (strain PAOl) gb|AAG08912.1 |AE004965_4

2898887 (AE004965) hypothetical protein [Pseudomonas aeruginosa] #N/A

sp|P39394|YJIW_ECOLI HYPOTHETICAL 14.6 KD

PROTEIN IN MCRB-HSDS INTERGENIC REGION

(F132) pir| |S56573 hypothetical 14.6K protein - Contig9 from-

(mcrB-hsdS intergenic région) ^"-

SΞQ ID n° 8327 PL-6676.1 2898933 to 41%

Escherichia coli gb| AA97244.l| (U14003)

2899175

ORF_fl32 [Escherichia coli] gb| AAC77303. l|

(AΞ000505) orf, ^"hypothetrcar- rotein

[Escherichia coli K12] #N/A

Contig9 from SΞQ ID n° 8328 PL-6675.1 2899198 to No Hits found 2899332 ^~ #N/A

Contig9 from emb|CAB53822.l| (AJ242593) putative repressor SEQ ID n° 8329 PL-6674.1 2899274 to m 293 protein [Bacteriophage A118]

2899609 #N/A sp | P47762 | PRIM_LISMO DNA PRIMASΞ gb |AAC43305.1 |

Contig9 from

(U13165) DNA primase [Listeria monocytogenes] SEQ ID n° 8330 PL-1699.1 2899797 to 163 prf] |2104269B DNA primase [Listeria

2903111 monocytogenes] SEQ ID n~808

Contig9 from gb|AAF89876.l| (AF173869) putative site-specific SEQ ID n° 8331 PL-1698.1 2903098 to 333 recombinase XerD [Staphylococcus

2904228 aureus] SEQ ID n~807 ref |NP_07363 .l| glutamate receptor, ionotropic,

N-methyl D-aspartate 2D [Rattus

Contig9 from norvegicus] pir|| 178557 N-methyl-D-aspartate SEQ ID n° 8332 PL-6916.2 2904050 to m 333 receptor chain NMDAR2D-2 - rat gb|AAC37647.l|

2904391

(L31612) NMDA receptor subunit NR2D [Rattus norvegicus] #N/A

Contig9 from SEQ ID n° 8333 PL-6667.1 2904421 to No Hits found

2904552 #N/A Contig9 from SEQ ID n° 8334 PL-6907.1 2904458 to m No Hits found

2904787 #N/A Contig9 from SEQ ID n° 8335 PL-6909.1 2904780 to No Hits found

2905046 #N/A

Contig9 from dbj |BAB07424.l| (AP001519) transposase (12) SEQ ID n° 8336 PL-3211.2 2905116 to 21% [Bacillus halodurans] 2906141 #N/A

Contig9 from SEQ ID n° 8337 PL-6469.1 2906177 to No Hits found

2906473 #N/A pir| [F81045 hemagglutinin/hemolysin-related protein NMB1768 [imported] -

Contig9 from

Neisseria meningitidis (group B strain MD58) SEQ ID n° 8338 PL-773.1 2906637 to 223 gb|AAF42109.l| (AE002526)

2908436 hemagglutinin/hemolysin-related prote±n~

[Neisseria meningitidis MC58] SEQ ID n~S608

Contig9 from SEQ ID n° 8339 PL-6467.1 2908433 to No Hits found

2908663 #N/A pir| |F81045 hemagglutinin/he olysin-related protein NMB1768 [imported] -

ContigS from

Neisseria meningitidis (group B strain MD58) SEQ ID n° 8340 PL-774.1 2908998 to 40% gb|AAF42109.l| (AE002526)

2911820 hemagglutinin/hemolysin-related protein

[Neisseria meningitidis MC58] SEQ ID n~3609

Contig9 from SEQ ID n° 8341 PL-6464.1 2911985 to No Hits found

2912137 #N/A Contig9 from SΞQ ID n° 8342 PL-3746.1 2912134 to No Hits found

2912649 SEQ ID n~2927 Contig9 from SEQ ID n° 8343 PL-3745.1 2913015 to No Hits found

2913374 SEQ ID n~2926 Contig9 from gb|AAG57523.l|AE005470_10 (AE005470) putative SEQ ID n° 8344 PL-6463.1 2915075 to m 753 virulence protein [Escherichia coli 0157 :H7]

2915326 #N/A Contig9 from SEQ ID n° 8345 PL-775.1 2915459 to No Hits found

2916082 SEQ ID n~3610

Contig9 from SEQ ID n° 8346 PL-6462.1 2916100 to No Hits found

2916252 #N/A ref |NP_052816.l| pXOl-120 [Bacillus anthracis]

Contig9 from pir| |H59105 hypothetical protein pXOl-120 - SEQ ID n° 8347 PL-6460.1 2916407 to 48% Bacillus anthracis virulence plasmid

2916565 pXOl gb|AAD32424 1-|ÂAD32424^" (AF065404) pXOl-120

[Bacillus anthracis] #N/A

Contig9 from SEQ ID n° 8348 PL-6459.1 2916643 to m No Hits found

^~ 2916801 #N/A Contig9 from SEQ ID n» 8349 PL-776.1 2917157 to No Hits found

2918233 SEQ ID n~3611 Contig9 from SΞQ ID n° 8350 PL-777.1 2918237 to No Hits found

2919016 SEQ ID n~3612 Contig9 from SEQ ID n° 8351 PL-778.1 2919511 to No Hits found

2920695 SEQ ID n~3613 pir| |E82459 probable acetyltransferase VCA0436

Contig9 from [imported] - Vibrio cholerae (group SEQ ID n° 8352 PL-3741.1 2920656 to 51

01 strain N16961) gb | AAF96342.1 | (AΞ004377)

2921198 acetyltransferase, putative [Vibrio cholerae] SEQ ID n~2924 pir| |E83595 cystathionine beta-synthase PA0399

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 8353 PL-779.1 2921528 to 703 (strain PAOl) gb | AAG03788.1 | AE004477_5

2922895 (AΞ004477) cystathionine beta-synthase

[Pseudomonas aeruginosa] SEQ ID n~3614 pir| |S52983 probable cystathionine gamma-lyase

Contig9 from (EC 4.4.1.1) - Erwinia herbicola SEQ ID n° 8354 PL-780.1 2922913 to 833 (fragment) gb|AAA64984.l| (M87280)

2924067 transcription must start in the vector; putative

ORF12 [Ξrwinia herbicola] SEQ ID n-3616

sp|P09743 |DE0D_EC0LI PURINE NUCLΞOSIDΞ

PHOSPHORYLASΞ (INOSINΞ PHOSPHORYLASΞ) (PNP) pir| |A27854 purine-nucleoside phosphorylase (ΞC

2.4.2.1) - Ξscherichia coli gb| AAA24401. l|

(M60917) purine nucleoside phosphorylase

Contig9 from [Ξscherichia coli] gb| AAA97280.1 | (U14003)

-SEQ—I-D-n-°r-8-355 -PL-781.1 2S24158 to m -8-9â purine-nucleoside phosphorylase [Escherichia

2S24874 coli] gb|AAC77337.l| (AE000508) purine- nucleoside phosphorylase [Escherichia coli K12] gb|AAG59565.l|AE005669_9 (AE005669) purine- nucleoside phosphorylase [Escherichia coli 0157:H7] SΞQ ID n~3617 sp | P07651 | DEOB_ΞCOLI PHOSPHOPENTOMUTASE

(PHOSPHODEOXYRIBOMUTASE) pir | |S56607 phosphopentomutase (EC 5.4.2.7) deoB -

ContigS from Ξscherichia coli gb| AAA97279.1 | (U14003)

SEQ ID n° 8356 PL-782.1 2S24S57 to m 913 phosphopentomutase [Escherichia coli] 2926180 gb|AAC77336.l| (AE000508) phosphopentomutase

[Escherichia coli K12] gb|AAG59564.l| AE00566S_8

(AE005669) phosphopentomutase [Ξscherichia coli

0157 :H7] SΞQ ID n~3618 sp | 00882 |DEOC_ΞCOLI DEOXYRIBOSE-PHOSPHATE ALDOLASE (PHOSPHODE0XYRIB0ALD0LASE) (DΞOXYRIBOALDOLASE) pir| |ADECD deoxyribose-

Contig9 from phosphate aldolase (EC 4.1.2.4) - Escherichia

SEQ ID n° 8357 PL-783.1 2926380 to m 833 coli gb|AAA97277.l| (U14003) deoxyribose- 2927159 phosphate aldolase [Escherichia coli] gb|AAC77334.l| (AE000508) 2-deoxyribθSe-5- phosphate aldolase [Ξscherichia coli K12] SEQ ID n~3619 pir| |H82087 NupC family protein VC2352

Contig9 from [imported] - Vibrio cholerae (group Ol

SΞQ ID n° 8358 PL-784.1 2927486 to m 83% strain N16961) gb| AAF95495. l| (AΞ004305) NupC 2928763 family protein [Vibrio cholerae] SEQ ID n~3620

sp|P46144|YEDJ_ECOLI HYPOTHETICAL 25.9 KDA

PROTEIN IN DCM-SERU INTΞRGΞNIC RΞGION pir| |F64960 membrane protein yedJ - Ξscherichia

-Contig9 from cόTï dbj | BAA1579Ô^".11^~ (D90835) ORF_ID:θ344#10 ;

SEQ ID n° 8359 PL-785.1 2929076 to 563 similar to [SwissProt Accession Number 2929771

P46144] [Bscherichia coli] gb| AAC75028.1 |

(AΕWCT-T8B^") ôrf7^"~hypothëtical protein

[Escherichia coli K12] SEQ ID n~3621

Contig9 from εp|P39408|YJJV_ECOLI PUTATIVE DEOXYRIBONUCLEASE

SEQ ID n° 8360 PL-786.1 2930005 to 76%

YJJV

2930778 —SΞQ—ID n~3622

Contig9 from

SEQ ID n° 8361 PL-6456.1 2930790 to m No Hits found

2930927 #N/A

Contιg9 from gb|AAC38623.l| (AF046867) insecticidal toxin

SΞQ ID n° 8362 PL-6455.1 2931241 to 57% complex protein TcaA [Photorhabdus

2931624 luminescens] #N/A

Contig9 from gb|AAC38625.l| (AF046867) insecticidal toxin

SEQ ID n° 8363 PL-787.1 2931689 to 953 complex protein TcaC [Photorhabdus

2936146 luminescens] SΞQ ID n~3623

Contig9 from gb|AAC38626.l| (AF046867) insecticidal toxin

SEQ ID n° 8364 PL-788.1 2936440 to m 953 complex protein TcaZ [Photorhabdus

2938032 luminescens] SEQ ID n~S624

Contig9 from

SΞQ ID n" 8365 PL-6450.1 2938661 to m No Hits found

2938852 #N/A pir| |G82578 conserved hypothetical protein

Contig9 from XF2273 [imported] - Xylella SEQ ID n° 8366 PL-789.1 2939099 to 82% fastidiosa (strain 9a5c)

2939767 gb|AAF85072.l|AE004039_7 (AE004039) conserved hypothetical protein [Xylella fastidiosa] SEQ ID n~3625 pir| | D64895 probable membrane protein bl433 -

Contig9 from

Escherichia coli gb | AAC74515 . l | (AE000240 ) SEQ ID n° 8367 PL-790.1 2940039 to 733 putative membrane transport protein [Escherichia

2941244 coli K12] SEQ ID n~3627

pir | | H82161 hypothetical protein VC1748

Contig9 from [imported] - Vibrio cholerae (group 01 SEQ ID n° 8368 PL-791.1 2941277 to p 38%

Strain N16961) gb] AAF94898.1 | (AE004252) - 2942398 hypothetical protein [Vibrio cholerae] SEQ ID n~3628 pir| |A82162 hypothetical protein VC1749

Contig9 from

[imported] - Vibrio cholerae (group 01

-SEQ ID n° 8369 PL-792.1 2942398 to. _ p S2-%- strain N16961) gb^~|^"AAF94^"899.1 |^~~(AE004252)

2943543 hypothetical protein [Vibrio cholerae] SEQ ID n~3629 pir] |B82162 hypothetical protein VC1750

Contig9 from

[imported] - ibrio cholerae (group 01

SEQ ID n° 8370 PL-793.1 2943540 to _p_ 51%

Strain N16S61) ^—gb~f7ffiF94900.l| (AΞ004252)

2944661 hypothetical protein [Vibrio cholerae] SΞQ ID n~3630

Contig9 from gb|AAG55653.l|AΞ005303_9 (AE005303) putative SEQ ID n° 8371 PL-794.1 2945494 to p 43% pilin subunit [Escherichia coli 0157 :H7]

2946075 SΞQ ID n~3631 sp|P33342]YΞHC_ECOLI HYPOTHETICAL 26.6 KD

FIMBRIAL CHAPERONE. IN GATY-MRP INTERGΞNIC

REGION PRECURSOR pir||E64978 hypothetical 26.6

Contig9 from kD fimbrial chaperone in mrp 5 ' région - SEQ ID n° 8372 PL-795.1 2946143 to p 61

Escherichia coli (strain K-12) gb]AAA60474. l|

2946841

(U00007) yehC [Escherichia coli] gb|AAC75l7l.l|

(AE000300) putative chaperone [Escherichia coli

K12] prf | | 2014253C yehC gène [Escherichia coli] SEQ ID n~3632 sp|P3334l| EHB_BCOLI HYPOTHETICAL OUTER MEMBRANE

USHER PROTEIN IN GATY-MRP INTERGENIC

REGION PRECURSOR pir||D64978 probable outer

Contig9 from membrane usher protein precursor (mrp 5 ' région) SEQ ID n° 8373 PL-796.1 2946867 to p 623 Escherichia coli (strain K-12)

2949341 gb|AAA60473.l| (U00007) yehB [Escherichia coli] gb|AAC75170.l| (AE000300) putative outer membrane protein [Escherichia coli K12] prf ( |2014253B yehB gène [Escherichia coli] SEQ ID n~3633

sp | 333 0 | YEHAJECOLI HYPOTHETICAL 36.9 KDA

PROTEIN IN GATY-MRP INTΞRGΞNIC RΞGION

SEQ ID n°_83

P33340] [Ξscherichia coli] gb | AAC75169.1 ]

(AE000300) putative type-1 fimbrial protein

[Escherichia coli K12] prf | |2014253A^~yehA gène

[Escherichia coli] SEQ ID n~3634

Contιg9 from gb|AAG58719.l|AE005584_l (AE005584) putative ATP SEQ ID n° 8375 PL-798.1 2951712 to p 55? binding protem [Escherichia coli 0157 :H7]

2952503 SEQ ID n~3635 pir| |C81103 alginate O-acetylation protein Algl, probable NMB1273 [imported] -

Contig9 from

Neisseria meningitidis (group B strain MD58) SEQ ID n° 8376 PL-799.1 2952709 to p 601 gb|AAF41650.l| (AΞ002475) alginate O-acetylation

2954130 protein Algl, putative [Neisseria meningitidis MC58] SEQ ID n~3636 pir| |A81839 probable periplasmic protein NMA1479

Contιg9 from [imported] - Neisseria meningitidis SEQ ID n° 8377 PL-800.1 2954117 to p 47% (group A strain Z2491) emb] CAB84712. l|

2955253 (AL162756) putative periplasmic protein

[Neisseria meningitidis Z2491] SEQ ID n~3639 pir| |B81839 probable periplasmic protein NMA1480

Contig9 from [imported] - Neisseria meningitidis SEQ ID n° 8378 PL-801.1 2955240 to p 43% (group A strain Z2491) emb|CAB84713.l|

2956460 (AL162756) putative periplasmic protein

[Neisseria meningitidis Z2491] SEQ ID n~36 0

Contig9 from gb|AAG31201.l|AF020810_2 (AF020810) Mig-14 SEQ ID n° 8379 PL-802.1 2956671 to p 51% [Salmonella enterica]

2957591 SEQ ID n~3641

sp|P46858|GNTU_ΞCOLI LOW-AFFINITY GLUCONATE

TRANSPORTER GLUCONATE PERMEASE) (GNT-I

SYSTEM) pir| | JC4989 gluconate permease

—eonxn-g9— rom- component U - Escherichia coli dbj |BAA12326.l| SΞQ ID n° 8380 PL-803.1 2957681 to 893

(D84362) low affinity gluconate permease

2959018

[Escherichia coli] gb| AAG58545.1] AE005567_6

(AEO 05567) ^~lc5w^~ affinity gluconate permease

[Escherichia coli 0157 :H7] SEQ ID n~3642 sp | P46859 | GNTK__ECOLI THΞRMORΞSISTANT

Contig9 from

GLUCONOKINASE (GLUCONATE KINASE 2)

SEQ ID n° 8381 PL-3739.1 2559018 to m 793 dbj | BAAÏ2325 1 | (D84362) thermorésistant

2959557 gluconokinase [Ξscherichia coli] SEQ ID n~2922 s | P 6860 | GNTR_ECOLI GLUCONATE UTILIZATION

ContigS from

SYSTEM GNT-I TRANSCRIPTIONAL REPRESSOR SEQ ID n° 8382 PL-804.1 2959726 to m 823 dbj ]BAA12324.l| (D84362) repressor [Ξscherichia

2960721 coli] SEQ ID n~3643

Contig9 from SΞQ ID n^» 8383 PL-3737.1 2967190 to No Hits found

2967633 SEQ ID n~2920 gb(AAG59203.l[AE005632_4 (AE005632)

Contig9 from phosphoribosylaminoimidazolecarboxamide SEQ ID n° 8384 PL-771.2 2967709 to 87% formyltransferase = AICAR formyltransferase; IMP

2969298 cyclohydrolase [Ξscherichia coli 0157 :H7] SΞQ ID n~3606

Contig9 from gb|AAG59202.l|AE005632_3 (AΞ005632) SEQ ID n° 8385 PL-770.1 2969320 to 83% phosphoribosylglycinamide synthetase = GAR

2970603 synthetase [Ξscherichia coli 0157 :H7] SEQ ID n~3605 Contig9 from gb|AAG59198.l|AE005631_13 (AE005631) orf, SEQ ID n° 8386 PL-769.1 2970622 to m 583 hypothetical protein [Escherichia coli 0157 :H7]

2971326 SEQ ID n~3603

sp|P0234 |DBHA_ECOLI DNA-BINDING PROTEIN HU- ALPHA (NS2) (HU-2) pir| |DNECS2 DNA-binding protein HU-2 - Ξscherichia coli emb|CAA29412.1 (

(X05994) HU 2 -protein (AA^~l-90^~) [Ξscherichia

Contig9 from coli] gb]AAC43098.l| (U00006) histonelike DNA-

SEQ ID n° 8387 PL-6426.1 2971332 to m 893 binding protein HU-alpha (NS2) (HU-2) 2971604 ^"~ [Escherichia cσli] gb|AAC76974.τT| (AE00Ô473J DNA-binding protein HU-alpha (HU-2) [Escherichia coli K12] gb|AAG59197.l|AE005631_12

(AEO05631) DNA-binding protein HU-alpha (HU-2) [Escherichia coli 0157 :H7] #N/A gb|AAF33519.l| (AF170176) 95% identity over 196

ContigS from amino acids with E. colihypothetical

SΞQ ID n° 8388 PL-3736.1 2971791 to m 873 22.6 kD protein in heme-hupa intergenic

2972381 région (yjag) (SW:P32680) [Salmonella typhimurium LT2] SEQ ID n~2919 pir| |A65207 hypothetical 24.9 kD protein in heme^ hupa intergenic région - Escherichia coli (strain K-12) gb| AAC43096.1 | (U00006)

Contig9 from similar to O.berteriana itochon. protein

SEQ ID n° 8389 PL-768.1 2972458 to 53% involved in cytochrome c biogenesis

2973126

[Escherichia coli] gb|AAC7697 .l| (AE000473) endonuclease V (deoxyinosine 3 'endoduclease) [Escherichia coli K12] SEQ ID n~3602 sp | P29680 | DCUP_ECOLI UROPORPHYRINOGΞN DECARBOXYLASE (URO-D) (UPD) pir| |H55206

Contig9 from uroporphyrinogen decarboxylase (EC 4.1.1.37) -

SEQ ID n° 8390 PL-767.1 2973131 to 91% Escherichia coli gb|AAC76971.l| (AE000473)

2974195 uroporphyrinogen decarboxylase [Ξscherichia coli

K12] SΞQ ID n~3601

Contig9 from gb|AAG59193.l|AE005631_8 (AE005631) orf,

SΞQ ID n° 8391 PL-766.1 2974308 to m 79% hypothetical protein [Escherichia coli 0157 :H7]

2975081 SΞQ ID n~3600

pir| |D8213S conserved hypothetical protein

Contig9 from VC1940 [imported] - Vibrio cholerae SEQ ID n° 8392 PL-765.1 2975366 to 67% (group Ol strain N16961) gb | AAF95088.1 j

2976028 (AE004269) conserved hypothetical protein

[Vibrio cholerae] SEQ ID n~3599 sp|P30136|THIC_ECOLI THIAMINΞ BIOSYNTHESIS

PROTEIN THIC pir| |E65206 thiamin biosynthesis^

Contig9 from protein thiC - Ξscherichia coli gb|AAC43092.l| SEQ ID n° 8393 PL-764.1 2976328 to (U00006) CG Site No. 115 [Escherichia coli]

2978265 gb|AAC76968.l| (AE000473) thiamin biosynthesis,

^{^"}pyrimidine moiety [Escherichia colï~

K12] SEQ ID n~3598 sp | 30137 | HIE_ΞCOLI THIAMINΞ-PHOSPHATΞ

PYROPHOSPHORYLASE (TMP PYROPHOSPHORYLASE)

(TMP-PPASE) (THIAMINΞ-PHOSPHATΞ SYNTHASE) pir||S35118 thiamin-phosphate pyrophosphorylase

Contig9 from

(EC 2.5.1.3) thiE - Escherichia coli SEQ ID n° 8394^" PL-762.1 2978249 to p 71 gb|AAC4309i.l| (U00006) thiE [Escherichia coli]

2978899 gb|AAB95617.lj (M88701) thiE [Escherichia coli] gb|AAC76967.l| (AE000473) thiamin biosynthesis, thiazole moiety [Escherichia coli

K12] SEQ ID n~3597

Contig9 from

SEQ ID n° 8395 PL-761.1 2978910 to 74% sp|P30138|THIF_ECOLI THIF PROTΞIN

2979659 SEQ ID n~3596

Contig9 from gb|AAG59188.l|AE005631_3 (AE005631) thiamin

SEQ ID n° 8396 PL-6424.1 2979656 to 56% biosynthesis, probable sulfur donor

2979856 [Escherichia coli 0157 :H7] #N/A

Contig9 from pir| |D49695 4-methyl-5- (beta-

SEQ ID n° 8397 PL-760.1 2979858 to 76 hydroxyethyl) thiazole monophosphate synthesis

2980625 protein ThiG - Escherichia coli SEQ ID n~3595 gb|AAD48429.l|AF154064_l (AF154064) ThiH

Contig9 from [Salmonella typhimurium] gb| AF33524.1] SEQ ID n° 8398 PL-759.1 2980673 to 77% (AF170176) 89% identity over 377 amino acids

2981764 with E. coli THIH (SW:P30140)

[Salmonella typhimurium LT2] SEQ ID n~35S3

Contig9 from SEQ ID n° 8399 PL-3735.1 2982169 to No Hits found

2982645 SEQ ID n~2918

Contig9 from SEQ ID n° 8400 PL-3734.1 2982957 to No Hits found

2983442 SEQ ID n~2917

Contig9 from- dbj |BAB06239.l| (AP001515) transposase related SEQ ID n° 8401 PL-758.1 2983476 to m 21% protein (20) [Bacillus halodurans]

2984501 SEQ ID n~3592 ref |NP_012318.l| Yjl217wp [Saccharomyces cerevisiae] sp |-P40893 |ΥJV7_YEAST HYPOTHETICAL

22.0 KD PROTEIN IN HXT11-HXT8 INTERGΞNIC RΞGION

Contig9 from pir||S5071O hypothetical protein YJL217W - yeast SΞQ ID n° 8402 PL-757.1 2984729 to m 64%

(Saccharomyces cerevisiae) emb| CAA83993.l|

2985310

(Z34098) ORF [Saccharomyces cerevisiae] emb|CAA89514.l| (Z49492) ORF YJL217W

[Saccharomyces cerevisiae] SEQ ID n~3591 pir| |B83205 hypothetical protein PA3532

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 8403 PL-756.1 2985325 to m 483 (Strain PAOl) gb|AAG06920.l| AΞ004773_9

2986476 (AE004773) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~3590

Contig9 from emb|CAC18787.l| (AL499607) putative hydrolase SEQ ID n° 8404 PL-755.1 2986548 to m 433 [Streptomyces coelicolor]

2987189 SEQ ID n~3589 pir] |T36915 probable zinc-binding dehydrogenase

Contig9 from Streptomyces coelicolor emb| CAB46402.1 | SEQ ID n° 8405 PL-754.1 2987194 to 44% (AL096743) putative zinc-binding dehydrogenase

2988255

[Streptomyces coelicolor A3 (2)] SEQ ID n~3588 pir] |G75036 4-aminobutyrate transaminase (EC

Contig9 from 2.6.1.19) PAB2386 - Pyrococcus abyssi SEQ ID n° 8406 PL-753.1 2988255 to m 51% (strain Orsay) emb|CAB50188.l| (AJ248287) 4-

2989508 AMINOBUTYRATB qui se dilate AMINOTRANSFΞRASE (EC

2.6.1.19) [Pyrococcus abyssi] SEQ ID n~3587

pir||E82367 probable multidrug résistance

Contig9 from protein VC0069 [imported] - Vibrio SΞQ ID n° 8407 PL-752.1 2990187 to p 533 cholerae (group 01 strain N16961)

^" 2991380 gb|AAF93247.1| (AE004098) multidrug résistance protein, putative [Vibrio cholerae] SΞQ ID n~3586 pir| |RGECMT regulatory protein malT - ₌ Contig9 from

⁼ Escherichia coli ^"" gb | AAC76443.11 ^""(AE000418)

SΞQ ID n° 8408 PL- 751.1 2991389 to m 79% positive regulator of mal regulon [Ξscherichia

2994103 coli K12] SΞQ ID n~3585

Contig9 from gb|AAG58518.l|AE005564_3 (AE005564) maltodextrin SΞQ^"ID-n°-8409 PL-750.1 2994645 to p 82% phosphorylase [Escherichia coli 0157 :H7]

2997047 SΞQ ID n~3584 s | P15977 |MALQ_ECOLI 4-ALPHA-GLUCANOTRANSFΞRASΞ

(AMYLOMALTASE) (DISPROPORTIONATING

ENZYMΞ) (D-ENZYME) pir||C65137 4-alpha-

Contig9 from glucanotransferase (ΞC 2.4.1.25) - Ξscherichia SEQ ID n° 8410 PL-749.1 2997057 to p 753 coli gb|AAA58 l4.l| (U18997) amylomaltase

2999144

[Ξscherichia coli] gbj AAC76441.1 | (AΞ000417) 4- alpha-glucanotransferase (amylomaltase)

[Ξscherichia coli K12] SΞQ ID n~3582 ref |NP_073225.l| ransposase of IS630 [Salmonella enterica serovar Choleraesuis] dbj |BAA01531. l|

Contig9 from

(D10689) M5 protein [Salmonella choleraesuis] SEQ ID n° 8411 PL-748.1 3000459 to 72% dbj |BAB20556.l| (AB040415) ransposase of IS630

3001472

[Salmonella enterica serovar

Choleraesuis] SEQ ID n~3581 pir| |H83457 hypothetical protein PA1508

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 8412 PL- 5412.1 3002417 to 443 (strain PAOl) gb] AAG04897.1] AΞ004579_9

3002689 (AE004579) hypothetical protein [Pseudomonas aeruginosa] #N/A pir| |E83542 hypothetical protein PA0821

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 8413 PL-747.1 3002693 to 283 (strain PAOl) gb|AAG04210.1 | AE004517_5

3003838 (AE004517) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~3580

pir| |E83542 hypothetical protein PA0821

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 8414 PL-746.1 3003876 to m 27% (strain PAOl) gb | AAG04210. l] AΞ004517_5

3005024 (AEO04517) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~3579 pir| |E83542 hypothetical protein PA0821

Contig9 from [importedJ- ^-^"Pseudomonas aeruginosa SEQ ID n° 8415 PL-745.1 3005059 to m 323 (strain PAOl) gb|AAG04210.1 |AΞ004517_5

3006054 (AE004517) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~3578

— Contig9 from SΞQ ID n° 8416 PL-744.1 3006221 to m No Hits found

3007579 SEQ ID n~3577 Contig9 from gb|AAG54536.l]AE005199_6 (AE005199) Z0267 gène SEQ ID n° 8417 PL-743.1 3007582 to m 41% product [Escherichia coli 0157 :H7]

3009723 SΞQ ID n~S576 pir] [D81308 probable intégral membrane protein

Contig9 from Cj 1055c [imported] - Campylobacter SEQ ID n° 8418 PL-742.1 3010416 to 46% jejuni (strain NCTC 11168) emb|CAB73311.l|

3012431 (AL139077) putative intégral membrane protein

[Campylobacter jejuni] SΞQ ID n~3575 sp|P07622|MALG_ECOLI MALTOSE TRANSPORT SYSTEM

PERMΞASΞ PROTΞIN MALG pir| |MMECMG maltose transport inner membrane protein malG -

Escherichia coli emb|CAA26528. l| (X02871) put. mal G protein (aa 1-296) [Escherichia coli]

Contig9 from gb|AAC43126.l| (U00006) maltose transport inner

SEQ ID n° 8419 PL-741.1 3012497 to m 923 membrane protein [Escherichia coli]

3013387 gb|AAC77002.l| (AE000476) part of maltose permease, inner membrane [Escherichia coli K12] gb|AAG59231.l|AE005636_3 (AΞ005636) part of maltose permease, inner membrane

[Ξscherichia coli 0157 :H7] SEQ ID n~3574

Contig9 from sp|P18812|MALF_ENTAE MALTOSE TRANSPORT SYSTEM

SEQ ID n° 8420 PL-740.1 3013400 to 803 PERMΞASE PROTEIN MALF pir| |S05332 inner

3014956 membrane protein malF - Enterobacter aerogenes SEQ ID n~S573

sp|P02928|MALE_ECOLI MALTOSE-BINDING PERIPLASMIC

PROTEIN PRΞCURSOR (MALTODEXTRIN-BINDING PROTEIN) (MMBP) pir| | JGECM periplasmic maltose- binding protein precursor - Escherichia coli gb|AAC43128.l| (U00006) periplasmic maltose- binding protein [Escherichia coli] gb|AAB59056. l| (J01648) periplasmic maltose-

Contig9 from binding protein [Escherichia coli]

SEQ ID n° 8421 PL-739.1 3015078 to m 87% gb|AAC77004.l| (AE000476) periplasmic maltose-

3016277 binding protein; substrate récognition for transport and chemotaxis [Escherichia coli K12] gb|AAG59233.l|AE005636_5 (AΞ005636) periplasmic maltose-binding protein; substrate récognition for transport and chemotaxis [Escherichia coli 0157 :H7] SEQ ID n~3571

Contig9 from SΞQ ID n° 8422 PL-6406.1 3016395 to No Hits found

3016511 #N/A pir| |MMECMK inner membrane protein malK -

Escherichia coli gb| AAC43129.l| (U00006) cytoplasmic membrane protein for maltose uptake

Contig9 from [Escherichia coli] gb|AAC77005.l| (AE000476)

SEQ ID n° 8423 PL-738.1 3016656 to 81% ATP-binding component of transport system for

3017765 maltose [Ξscherichia coli K12] gb[AAG59234.l|AE005636_6 (AE005636) ATP-binding component of transport System for maltose

[Escherichia coli 0157 :H7] SEQ ID n~3570 sp|P31242|LAMB_KLEPN MALTOPORIN PRECURSOR

Contig9 from (MALTOSE-INDUCIBLE PORIN) pir||S23581 lamB

SEQ ID n° 8424 PL-737.1 3017802 to 853 protein precursor - Klebsiella pneumoniae

3019088 emb|CAA47377.l| (X66952) maltoporm [Klebsiella pneumoniae] SEQ ID n~3569

sp|P0384l]MALM_ECOLI MALTOSE OPERON PERIPLASMIC

PROTEIN PRΞCURSOR pir| |BVECMM maltose operon

Contig9 from periplasmic protein malM - Escherichia coli

SEQ ID n° 8425 PL-736.1 3019337 to 70% emb|CAA28166.1 (X04477) periplasmic protein (AA

3020269 1-306) [Escherichia coli] gb|AAC77007.l| (AE000477) periplasmic protein of mal regulon

[Ξscherichia coli K12] SΞQ ID n~3568

Contig9 from

SEQ ID n° 8426 PL-734.1 3020945 to No Hits found

3021865 SΞQ ID n~3567

— sp|P27127|RFAB_ΞCOLI LIPOPOLYSACCHARIDE lr6--^~

GALACTOSYLTRANSFΞRASΞ (UDP-D-

GALACTOSE- - (GLUCOSYL) LIPOPOLYSACCHARIDE-ALPHA-1 ,

3 -D-GALACTOSYLTRANSFERASE) pir] |B42982 UDP-D- galactose-- (glucosyl) lipopolysaccharide-alpha-1,

3 -D-galactosyltransferase (EC 2.4.1.-) -

Contig9 from Escherichia coli gb|AAA24085.l|

SEQ ID n° 8427 PL-733.1 3022174 to 523 (M80599) lipopolysaccharide core biosynthesis

3023253 protein [Ξscherichia coli] gb]AAB18605.l| (U00039) UDP-D- galactose.- (glucosyl) lipopolysaccharide

-alpha-1, 3 -D-galactosyltransferase [Bscherichia coli] gb|AAC76652.l[ (AE000440) UDP-D- galactose: (glucosyl) lipopolysaccharide-1, 6-

D-galactosyltransferase [Ξscherichia coli K12] SEQ ID n~3566

Contig9 from pir| |T30588 hypothetical protein PCZA361.23 -

SEQ ID n° 8428 PL-732.1 3023264 to m 38% Amycolatopsis orientalis emb ] CAA11778.1 | 3024043 (AJ223998) PCZA361.23 [Amycolatopsis orientalis] SΞQ ID n~3565 Contig9 from

SΞQ ID n° 8429 PL-731.1 3024045 to m No Hits found 3024791 SΞQ ID n~3564 Contig9 from dbj |BAB02685.l| (AB018114)

SEQ ID n° 8430 PL-730.1 3024802 to m 493 gb| AAD14522. l~gene_id:MGF10.2~similar to unknown 3025428 protein [Arabidopsis thaliana] SΞQ ID n~S563

Contig9 from dbj ]BAB07775.l| (AP001520) aminotransferase

SEQ ID n° 8431 PL-729.1 3025910 to 493 required for NADjDiosynthesis (NifS

3027070 protein) [Bacillus halodurans] SΞQ ID n~3561

Contig9 from dbj |BAB14754.l| (AK023984) unnamed protein

SΞQ ID n° 8432 PL-728.1 3027070 to m 45% product [Homo sapiens]

3027726 SEQ ID n~3560

Contig9 from SEQ ID n° 8433 PL-727.1 3027739 to m No Hits found

3028617 SΞQ ID n~3559 Contig9 from emb|CAB53171.l| (AL109969) putative SEQ ID n° 8434 PL-6401.1 3029024^~to 573 transcriptional regulator [Yersinia pestis]

3029227 #N/A ref |NP_046944.l| gp48 [Bacteriophage N15]

Contig9 from pir| |T13135 protein gp48 - phage N15 SEQ ID n° 8435 PL-6400.1 302S351 to m 543 gb|AAC19087.l| (AF064539) gp48 [Bacteriophage

3029602

N15] #N/A ref |NP_046945^_l| gp49 [Bacteriophage N15]

Contig9 from pir| |T13136 protein gp49 - phage N15 SEQ ID n° 8436 PL-6399.1 3029619 to 553 gb|AAC19088.l| (AF064539) gp49 [Bacteriophage

3029942

N15] #N/A

Contig9 from emb | CAB53172 . l | (AL109969 ) hypothetical protein SEQ ID n° 8437 PL-6398.1 3030097 to 51% [Yersinia pestis]

3030396 #N/A sp | P00577 | RPOC_ECOLI DNA-DIRECTED RNA POLYMERASΞ BBTA' CHAIN (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASΞ BETA' SUBUNIT) pir | | RNECC DNA- directed RNA polymerase (EC 2 . 7. 7. 6) beta ' chain

Contig9 from - Escherichia coli emb | CAA23626 . l | SEQ ID n° 8438 PL-725.1 3030410 to 94%

(V00339) rpoC [Escherichia coli] gb | AAC7696 . 1 |

3034630

(AE000472 ) RNA polymerase , beta prime subunit

[Escherichia coli K12] gb | AAG59184 . l | AE005630_4

(AE005630 ) RNA polymerase , beta prime subunit

[Escherichia coli 0157 : H7] SEQ ID n~3558

sp] O 0575 ]RPOB_BCOLI DNA-DIRECTED RNA POLYMERASE BETA CHAIN (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) pir] | RNECB DNA-

Contig9 from directed RNA polymerase (BC 2.7.7.6) beta chain

SEQ ID n° 8439 PL-724.1 3034761 to 97% Escherichia coli gb|AAB18647.1]

3038789 (U76222) RNA polymerase beta subunit

[Ξscherichia coli] gb[AAC76961^"".T|^": AE000472^")

RNA polymerase, beta subunit [Escherichia coli

K12] SEQ ID n~3557 sp|P1808l|RL7_SALTY 50S RIBOSOMAL PROTEIN L7/L12

(L8) pir| |R5EB12 ribosomal protein- L7/L12 - Salmonella typhimurium emb |CAA37246. l| (X53072) ribosomal protein L7 /L12 (AA 1-121) [Salmonella

Contig9 from typhimurium] gb| AAF33498.1 | (AF170176) SEQ ID n° 8440 PL-6391.1 3039129 to 86%

Salmonella typhimurium 50S ribosomal protein L7

3039500

(RPLL) (SW:P18981) ; contains similarity to Pfam domain _^PF00542

(Ribosomal_L12) , Score=133.2, E=4.6e-36, N=l

[Salmonella typhimurium LT2] #N/A sp|P02408|RL10_ECOLI 50S RIBOSOMAL PROTEIN L10

(L8) pir| |R5ΞC10 ribosomal protein L10 [validated] - Ξscherichia coli emb|CAA23623.l|

(V00339) rplJ (L10) [Ξscherichia coli]

Contig9 from gb|AAC43083.l| (U00006) 50S ribosomal subunit

SEQ ID n° 8441 PL-3732.1 3039564 to m protein L10 [Ξscherichia coli] gb| AC76959. l| 3040070

(AE000472) 50S ribosomal subunit protein L10

[Escherichia coli K12] gb| AAG59181. l| AEO 05630_1

(AE005630) 50S ribosomal subunit protein L10

[Escherichia coli 0157 :H7] SEQ ID n~2916

sp|P02384|RLl_ΞCOLI 50S RIBOSOMAL PROTBIN Ll pir| |R5ΞCl ribosomal protein Ll [validated] -

Escherichia coli emb ] CAA23522. l| (V00333) rplA

(Ll)^~TΞscherichia coli] gb| AAC43082. l| (U00006)

50S ribosomal subunit protein Ll [Escherichia

Contig9 from coli] gb|AAC76358.l| (AE000472) 50S ribosomal

SEQ ID n° 8442 PL-123_._1_ _- -0A0-3_a-7_to 963 sùbiunït -protein LIT régulâtes synthesis of 3041088

Ll and LU [Escherichia coli K12] gb|AAG59180.l|AE005629_9 (AE005629) 50S ribosomal subunit protein Ll, régulâtes synthesis—of — Ll and LU [Escherichia coli 0157 :H7] SΞQ ID n-3556

Sp|P09763 |RL11_SERMA 50S RIBOSOMAL PROTBIN LU

Contig9 from pir| |R5SEll ribosomal protein LU - Serratia SΞQ ID n° 8443 PL-3731.1 3041092 to m 80% marcescens emb | CAA31095. l| (X12584) LU protein

3041520

(AA 1-142) [Serratia marcescens] SΞQ ID n~2915 s | 16921 | USG_ECOLI TRANSCRIPTION

ANTITΞRMINATION PROTEIN NUSG pir| | TWECNG transcription antitermination factor nusG -

Escherichia coli gb| AAA24622.l| (M30610) nusG

ContigS from protein [Escherichia coli] gb|AAC43080.l| SΞQ ID n° 8444 PL-3730.1 3041682 to m 363 (U00006) nusG [Escherichia coli] gb [AAC76956.l|

3042227 (AE000472) component in transcription antitermination [Escherichia coli

K12] gb[AAG59178.l[AE005629__7 (AE005629) component in transcription antitermination [Escherichia coli 0157 :H7] SΞQ ID n~2914 gb|AAF33494.l| (AF170176) 96% identity over 127 amino acids with E. coli protein-

Contig9 from export protein (SΞCE) (SW:P16920) ; contains

SEQ ID n° 8445 PL-6389.1 3042229 to 803 similarity to Pfam domain PF00584 (SecE) ,

3042612 Score=96.3, E=6,2e-25, N=l

[Salmonella typhimurium LT2] #N/A

Contig9 from pir| |S13560 translation elongation factor EF-

SEQ ID n° 8446 PL-722.1 3042887 to m 323 Tu.A - Salmonella typhimurium

3044071 SΞQ ID n~3555

sp|P26229|EFG_SALTY ΞLONGATION FACTOR G (ΞF-G)

Contig9 from pir] | C1424 translation elongation factor EF-G -

SEQ ID n° 8447 PL-721.1 3044144 to 903 Salmonella typhimurium emb|CAA45880. l| (X64591) 3046252 elongation factor G [Salmonella typhimurium] SΞQ ID n~3554

Contig9 from gb|AAG58448.l|AE005558_l (AΞ005558) 30S SΞQ ID n° 8448 PL-3729.1 3046333 to m 873 ribosomal subunit protein S7, initi tes assembly

3046803 [Escherichi ^"coli 0157 :H7] SEQ ID n~2912 sp|P02367|RS12_ECOLI 30S RIBOSOMAL PROTBIN S12 pir| |R3EC12 ribosomal protein S12 [validated] -

Escherichia coli pir| | JH0443 ribosomal protein

S12 - Salmonella typhimurium emb | CAA23648.1 |

(V00355) reading frame (S12 protein)

[Escherichia coli] gb|AAA50988.l| (J01691) ribosomal protein S12 [Escherichia coli] gb|AAA27216.1] (M68548) ribosomal protein S12

[Salmonella typhimurium] gb | AAA72526.l]

Contig9 from

(M12787) ribosomal protein S12 [unidentified SEQ ID n° 8449 PL-3728.1 3046901 to m 723 cloning vector] gb| AAA58139.l| (U18997) 30S

3047275 ribosomal subunit protein S12 [Ξscherichia coli] gb]AAC76367.ι] (AE000410) 30S ribosomal subunit protein S12 [Ξscherichia coli K12] gb|AAC53716.l| (U87107) small ribosomal protein

[Cloning vector pAL-F] gb ] AAG30937.1 |

(AF312717) ribosomal protein S12 [Escherichia coli K12] gb|AAG58449.l|AE005558_2 (AE005558)

3 OS ribosomal subunit protein S12 [Escherichia

COli 0157:H7] SΞQ ID n~2911 sp|P45530|YHEL_ECOLI HYPOTHETICAL 10.7 KDA

PROTEIN IN RPSL-FKPA INTERGENIC REGION pir| |B65128 hypothetical 10.7 kD protein in rpsl

Contig9 from fkpa intergenic région - Escherichia SEQ ID n° 8450 PL-6383.1 3047412 to m 623 coli (strain K-12) gb| AAA58140. l| (U18997)

3047699

0RF_f95 [Escherichia coli] gb| AAC76368.11

(AΞ000410) orf, hypothetical protein

[Ξscherichia coli K12] #N/A

Contig9 from gb|AAG58451.l]AE005558_4 (AE005558) orf, SEQ ID n° 8451 PL-6382.1 3047720 to m 743 hypothetical protein [Escherichia coli 0157 :H7]

3048079 #N/A sp|P45532|YHEN_ECOLI HYPOTHETICAL 13.6 KD

PROTEIN IN RPSL-FKPA INTERGENIC REGION pir| |D65128 hypothetical 13.6 kD protein in rpsl-

ContigS from fkpa intergenic région - Escherichia

SEQ ID n° 8452 PL-6381.1 3048089 to 78% coli (strain K-12) gb[AAA58142.l| (U18997) 3048484

ORF_fl28 [Escherichia coli] gb|AAC76370.l]

(AΞ000410) orf, hypothetical protein

[Ξscherichia coli K12] #N/A

Contig9 from gb|AAG58453.l|AE005558_6 (AΞ005558) orf, SEQ ID n° 8453 PL-720.1 3048484 to 87% hypothetical protein [Ξscherichia coli 0157 :H7]

3049218 SΞQ ID n~3553 Contig9 from SEQ ID n° 8454 PL-6380.1 3049280 to No Hits found

3049483 #N/A Contig9 from gb|AAG58454.l|AE005558_7 (AE005558) FKBP-type SEQ ID n° 8455 PL-719.1 3049500 to m 81% peptidyl-prolyl cis-trans isomerase (rotamase)

3050264 [Ξscherichia coli 0157 :H7] SEQ ID n~3551 sp|P30857|SLYX_ECOLI SLYX PROTEIN pir||A49988 slyX protein - Escherichia coli gb|AAA18573.l|

(L13261) orf72 [Ξscherichia coli]

Contig9 from gb|AAA58145.l] (U18997) slyD [Ξscherichia coli] SEQ ID n° 8456 PL-6379.1 3050515 to 56% gb|AAC76373 ,l| (AE000411) host factor for lysis

3050733 of phiX174 infection [Ξscherichia coli K12] gb|AAG58455.l|AΞ005558_8 (AE005558) host factor for lysis of phiX174 infection

[Escherichia coli 0157 :H7] #N/A

sp|P30856|SLYD_ECOLI FKBP-TYPE PEPTIDYL-PROLYL

CIS-TRANS ISOMERASE SLYD (PPIASE)

(ROTAMASE) (HISTIDINE RICH PROTEIN) (WHP) pir| |A49987 probable fkbP-type peptidyl-prolyl cis-trans isomerase slyD -

Escherichia coli emb| CAA79705.1 | (Z21496) histidine rich protein [Escherichia coli]

Contig9 from gb|AAA18574.l| (L13261) sensitivity to lysis

SEQ ID n° 8457 PL-718.1 3050839 to m 843 gène [Escherichia coli] gb|AAA58146. l| (U18997)

3051411 histidine rich protein [Ξscherichia coli] gb|AAC4145^"8Tir (L28082) slyD gène product

[Escherichia coli] gb| AAC76374.l| (AE000411)

FKBP-type peptidyl-prolyl cis-trans isomerase

(rotamase) [Escherichia coli K12] gb|AAG58456.l|AE005558_9 (AE005558) FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase)

[Escherichia coli 0157 :H7] SEQ ID n~3550 sp|P56622|YHEV_ECOLI HYPOTHΞTICAL 7.6 KD PROTΞIN

Contig9 from

IN SLYD-KEFB INTERGENIC REGION SEQ ID n° 8458 PL-6377.1 3051500 to 67% gb|AAG58457.l|AΞ005558_10 (AΞ005558) Z4708 gène

3051703 product [Escherichia coli 0157 :H7] #N/A sp|P45535|YHΞS_ΞCOLI HYPOTHETICAL ABC

TRANSPORTER ATP-BINDING PROTEIN YHES pir| |C65129 hypothetical ABC transporter in kifb

Contig9 from prkb intergenic région - Escherichia

SEQ ID n° 8459 PL-717.1 3051996 to 823 coli (strain K-12) gb| AAA58149. l] (U18997)

3053921 ORF_o637 [Escherichia coli] gb|AAC76377.l|

(AΞ000411) putative ATP-binding component of a transport system [Ξscherichia coli

K12] SEQ ID n~354S

Contigg from emb|CAB61438.l| (Z32686) MrpI [Proteus

SEQ ID n° 8460 PL-716.1 3054256 to 773 mirabilis]

3054828 SΞQ ID n~3548

sp|P1342l|FMA__SERMA FIMBRIA A PROTEIN PRECURSOR

_ Contig9 from pir| |A31096 fimbrial protein precursor, mannose-

SEQ ID n° 8461 PL-3727.1 3055522 to 67% resistant - Serratia marcescens

3056088 (strain US46) gb| AAA26576.l| (M21161) SmfA protein [Serratia marcescens] SEQ ID n~2910

Contig9 from emb | CAA83634. 1 | (Z32686)_mrpB—[-Proteus

SEQ ID n° 8462 PL-715.1 3056218 to 35% mirabilis]

3056814 SEQ ID n~3547

Conti 9 from emb|CAA83635.l| (Z32686) mrpC [Proteus

SEQ ID n° 8463 PL-714.1 3056829 to 653 mirabilis]

3059417 SEQ ID n~3546

Contig9 from emb |CAA83636.l[ (Z32686) rpD [Proteus

SEQ ID n° 8464 PL-713.1 3059747 to 71% mirabilis]

3060505 SEQ ID n~3545

Contig9 from emb|CAA83639.2 | (Z32686) mrpG [Proteus

SEQ ID n° 8465 PL-712.1 3060548 to 43% mirabilis]

3061141 SEQ ID n~3544

Contig9 from emb|CAB61439.l| (Z32686) mrpH [Proteus

SEQ ID n° 8466 PL-711.1 3061184 to p 46% mirabilis]

3061981 SEQ ID n~3543

Contig9 from

SEQ ID n° 8467 PL-3724.1 3062014 to p No Hits found

3062553 SEQ ID n~2908

pir| |T20770 hypothetical protein F11C3.3 -

Caenorhabditis elegans pir| |MWKW myosin heavy chain B [similarity] - Caenorhabditis elegans emb|CAB04089.l| (Z81499) contains similarity to

Pfam domain: PF00063 (Myosin head

(motor domain)), Score=1558.5, E-value=0, N=l;

PF01576^" ~ (Myosin tail), Score=1727. f

Contig9 from E-value=0, N=3~cDNA EST EMBL:T02297

SEQ ID n° 8468 PL- 710.1 3062550 to P 29% cornes from this gène; cDNA EST ΞMBL:T00788

3063812 cornes from this gène; c> emb | CAB05505.1 |

^~(Z^"83107)^"""contains similarity to Pfam domain:

PF00063 (Myosin head (motor domain)), Score=1558.5, B-value=0, N=l; PF01576

(Myosin tail), Score=1727.6, Ξ-value=0, N=3~cDNA

ΞST ΞMBL:T02297 cornes from this gène; CDNA EST ΞMBL:T00788 cornes from this gène; c> SΞQ ID n~3542

Contig9 from emb|CAB6lS37.l| (AL133278) putative lysR-family

SEQ ID n° 8469 PL-709.1 3064015 to m 30% trancsriptional regulator

3064905 [Streptomyces coelicolor A3 (2)] SΞQ ID n~3540

Contig9 from

SEQ ID n° 8470 PL-3723.1 3065324 to No Hits found

3065776 SΞQ ID n~2907 sp|P77354|YAFU_EC0LI HYPOTHΞTICAL 12.1 KD

PROTΞIN IN DNAQ-GMHA INTERGΞNIC REGION

Contig9 from pir||C64746 yafU protein - Escherichia coli

SΞQ ID n° 8471 PL-708.1 3066594 to 143 gb|AAB08640.l| (U70214) hypothetical protein

3067424

[Escherichia coli] gb|AAC7332 .l] (AE000130) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~3539

Contig9 from

SEQ ID n° 8472 PL-6371.1 3067507 to m No Hits found

3067713 #N/A

Contig9 from gb|AAG54517.l|AΞ005197_6 (AE005197) Z0248 gène

SEQ ID n° 8473 PL-3722.1 3068059 to 65% product [Ξscherichia coli 0157 :H7]

3068538 SEQ ID n~2906

pir| |G82352 GckR family protein VC0206

Contig9 from

[imported] - Vibrio cholerae (group 01 SEQ ID n° 8474 PL-707.1 3068817 to p ^"813 strain N16961) gb|AAF93382. l| (AE004110) GckR 3069722 family protein [Vibrio cholerae] SEQ ID n~3538 pir||H82352 probable PTS system, sucrose- specific IIBC component VC0207

Contig9-.f-rem

[imported] - Vibrio cholerae (group όl strain

SEQ ID n° 8475 PL-706.1 3069753 to p 813

N16961) gb|AAF93383.l| (AE004110) PTS System,

3071231 sucrose-specific IIBC component, putative

[Vibrio cholerae] SEQ ID n~3537 pir| |B83356 conserved ^"hypothetical protein

Contig9 from PA2306 [imported] - Pseudomonas SEQ ID n° 8476 PL-705.1 3071272 to m 583 aeruginosa (strain PAOl)

3071880 gb|AAG05694.l| AEO04657_1 (AE004657) conserved hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~3536

Contig9 from gb|AAC26596.l( (U83995) putative protease SEQ ID n° 8477 PL-704.1 3071976 to m 593 [Porphyrόmonas gingivalis]

3072860 SEQ ID n~S535 sp|P45524|YHET_ECOLI HYPOTHETICAL 38.5 KD

PROTEIN IN KIFB-PRKB INTERGΞNIC REGION pir| |D65129 hypothetical 38.5 kD protein in kifb-

Contig9 from prkb intergenic région - Escherichia SEQ ID n° 8478 PL-703.1 3072981 to p 783 coli (strain K-12) gb| AAA58150.1 | (U18997)

3073958

ORF_o340 [Escherichia coli] gb| AC76378.1]

(AE000411) orf, hypothetical protein

[Escherichia coli K12] SEQ ID n~3534

sp|P45536|YHEU_EC0LI HYPOTHETICAL 8.5 KD PROTEIN

IN KIFB-PRKB INTERGENIC REGION pir | |E65129 hypothetical 8.5 kD protein in kifb-prkb intergenic région - Escherichia coli

Contig9 from (strain K-12) gb | AA58151.1 [ (U18997) ORF_o72; SEQ ID n° 8479 PL-6369.1 3073958 to 533 alternate ORF with good statistics, no ^{= "} 3074176 ^~ïrameshift found [Escherichia ^"cô Ï^"]^-" gb|AAC76379.l| (AE000411) orf, hypothetical protein [Escherichia coli K12] gb|AAG58462.l|AE005558_15 (AE005558) orf, hypothetical protein [Escherichia coli—0157 :H7] #N/A sp | P37307 | KPPR_ECOLI PROBABLE

PHOSPHORIBULOKINASE (PHOSPHOPENTOKINASΞ) (PRK)

Contig9 from pir] |F65129 phosphoribulokinase (EC 2.7.1.19) -

SEQ ID n° 8480 PL-702.1 3074195 to 933

Escherichia coli (strain K-12) gb|AAC76380 ,l|

3075064

(AΞ000411) probable phosphoribulokinase

[Escherichia coli K12] SEQ ID n~3533

Contig9 from emb|CAA6l607.l| (X89443) ORF2 [Erwinia

SEQ ID n° 8481 PL-6368.1 3075190 to m 86% chrysanthemi]

3075597 #N/A

sp|P03020|CRP_ΞCOLI CATABOLITE GΞNE ACTIVATOR

(CAMP RECEPTOR- PROTEIN) (CAMP-RΞGULATORY

PROTΞIN) pir| IQRΞCC cAMP receptor protein -

Escherichia coli pdb|lG6N|A Chain A, 2.1

Angstrom Structure Of Cap-Camp pdb|lG6N|B Chain

B, 2.1 Angstrom Structure Of Cap-Camp pdb| CGP^"|Â^"Cha rT A, Catabolite Gène Activator

ProteinDNA COMPLEX, ADENOSINΞ-3 ' , 5 ' -

Contιg9 from

Cyclic-Monophosphate gb|AAA23601.l| (J01598)

SEQ ID n° 8482 PL-701.1 3075918 to 953 cAMP receptor protein (crp) [Escherichia coli] 3076550 gb | AA26515. î | (M13772) catabolite gène activator protein [Shigella flexneri] gb]AAA58154.l| (U18997) cyclic AMP receptor protein [Escherichia coli] gb| AAC76382.1 |

(AEO00411) cyclic AMP receptor protein

[Escherichia coli K12] gb|AAG58465. l|AE005559_1

(AE005559) cyclic AMP receptor protein

[Escherichia coli 0157 :H7] SEQ ID n~S532 sp | PI8335 |ARGD 3COLI ACETYLORNITHINΞ

AMINOTRANSFΞRASΞ (ACOAT) pir| |B65130 acetylornithine transaminase (BC 2.6.1.11) -

Contιg9 from

Ξscherichia coli gb|AAA58l56.l| (U18997)

SEQ ID n° 8483 PL-700.1 3076600 to 81% acetylornitine delta-aminotransferase

3077811

[Escherichia coli] gb|AAC76384.l| (AΞ000412) acetylornithine delta-aminotransferase

[Escherichia coli K12] SΞQ ID n~3531 sp|P06195|PABA_SΞRMA PARA-AMINOBΞNZOATΞ SYNTHASΞ

GLUTAMINE AMIDOTRANSFERASΞ COMPONENT II

Contig9 from

(ADC SYNTHASE) pir] |S09635 pabA protein - SEQ ID n° 8484 PL-3721.1 3077935 to m 85%

Serratia marcescens emb|CAA26452.l| (X02605)

3078510 pabA gène product (aa 1-191) [Serratia marcescens] SEQ ID n~2905

sp|P7600l|YCGJ_ECOLI HYPOTHETICAL 13.4 KDA

PROTEIN IN MINC-SHEA INTERGENIC REGION Contig9 from PRECURSOR pir] |F64863 ycgJ protein precursor -

Escherichia coli gb | AAC74261.1 | (AE000216) orf,

SEQ ID n° 8485 PL-6367.1 3078759 to 363 hypothetical protein [Escherichia coli K12]

3079109 dbj |BAA36011.1 | (D90751) 0RF_ID :θ243#9

[Escherichia coli] dbj |BAA36024.1 | (D90752)

ORF_lD:o243#9 [Escherichia coli] #N/A sp| 053021 |PPIA_ΞRWCH PEPTIDYL-PROLYL CIS-TRANS

Contig9 from ISOMERASE A PRECURSOR (PPIASE A)

SEQ ID n° 8486 PL-3720.1 3079209 to m 833 (ROTAMASE A) (CYCLOPHILIN A) emb j CAA70935.1 |

3079778 (Y09804) peptidylprolyl cis-trans isomerase

[Ξrwinia chrysanthemi] SΞQ ID n~2904

Contig9 from sp|P24253 |YIHA_ECOLI HYPOTHETICAL GTP-BINDING

SEQ ID n° 8487 PL-699.1 3080086 to 643 PROTEIN IN POLA-HEMN INTERGΞNIC REGION

3080718 SEQ ID n~3529

Contig9 from gb|AAC35427.l| (U97057) beta-lactamase

SEQ ID n° 8488 PL-698.1 3081191 to 233 inhibitory protein II precursor

3082483 [Streptomyces exfoliatus] SEQ ID n~3528

Contig9 from

SΞQ ID n" 8489 PL-6366.1 3082862 to No Hits found

3083080 #N/A

Contig9 from

SΞQ ID n° 8490 PL-6365.1 3083109 to No Hits found

3083330 #N/A sp|P00582 [DP01_ΞCOLI DNA POLYMERASE I (POL I) pir] |DJΞCI DNA-directed DNA polymerase (ΞC

2.7.7.7) I - Escherichia coli emb|CAA 3607. l|

(V00317) DNA polymerase I [Ξscherichia coli]

Contig9 from gb|AAA24402.l| (J01663) DNA polymerase I

SEQ ID n° 8491 PL-697.1 3083422 to 843

[Escherichia coli] gb| AB02998.1 | (L19201) DNA

3086211 polymerase I [Bscherichia coli] gb(AAC76861.1 j

(AE000461) DNA polymerase I, 3' --> 5' polymerase, 5' --> 3' and 3' --> 5' exonuclease [Escherichia coli K12] SEQ ID n~3527

ref |NP_073225. l| ransposase of IS630 [Salmonella enterica serovar Choleraesuis] dbj |BAA01531. l|

Contig9 from (D10689) M5 protein [Salmonella choleraesuis]

SEQ ID n° 8492—PL7=^"696τl 3086686 to 72% dbj |BAB20556.1 | (AB040415) ransposase of IS630

3087699

[Salmonella enterica serovar

Choleraesuis] SEQ ID n~3526

Contig9 from gb |AAG57162 . l |AE005436_9 (AE005436) Z3269 gene

SEQ ID n° 8493 PL-6363.1 3087825 to 71% product [Escherichia coli 0157 : H7]

3088064 #N/A

Contig9 from ref | NP_053136 . ,1| orf74 [Escherichia coli]

SEQ ID n° 8434 PL-695.1 3088092 to 69% ^"dbj^"| BAA84909 . l | (AB024946) orf74 [Escherichia^"

309071S coli] SEQ ID n~3525 pi |G75064 hypothetical protein PAB1002 -

Contig9 from Pyrococcus abyssi (strain Orsay)

SEQ ID n° 8495 PL-694.1 3090785 to 45% emb|CAB50412.l| (AJ248287) hypothetical protein 3091861

[Pyrococcus abyssi] SEQ ID n~3524

Contig9 from sp | Q9XBV2 | DSBA_YBRPΞ THIOL :DISULFIDE INTERCHANGE

SEQ ID n° 8496 PL-693.1 3092017 to 533 PROTEIN DSBA PRECURSOR gb | AAD38401.11 AF155130_1

3092640 (AF155130) DsbA [Yersinia pestis] SΞQ ID n~3523

Contig9 from gb|AAD47614.l|AF146615_2 (AF146615) YihE

SEQ ID n° 8497 PL-692.1 3092661 to 773 [Pectobacterium carotovorum subsp. carotovorum]

3093653 SEQ ID n~3522 pdb|lE5K]A Chain A, Crystal Structure Of The

ContigS from

Molybdenum Cofactor Biosynthesis

SEQ ID n° 8498 PL-691.1 3093862 to 583

Protein Moba (Protein Fa) From Escherichia Coli 3094461

At Near Atomic Resolution SΞQ ID n~S521

Contig9 from sp | P32125 | MOBB_ECOLI MOLYBDOPTERIN-GUANINE

SEQ ID n° 8499 PL-3718.1 3094458 to 67% DINUCLEOTIDE BIOSYNTHESIS PROTEIN B

3094976 SEQ ID n~2902

Contig9 from sp|Q0217l|MYSP_ONCVO PARAMYOSIN gb|AAA29431.l|

SEQ ID n° 8500 PL-690.1 3095057 to 25% (M95813) paramyosin [Onchocerca volvulus]

3096709 SEQ ID n~3520

Contig9 from

SEQ ID n° 8501 PL-689.1 3096706 to m No Hits found

3097794 SEQ ID n~3518

Contig9 from gb| AAG58632.l|AE005575_l (AE005575) glutathione SΞQ ID n° 8502 PL-688.1 3098060 to m. 903 oxidoreductase [Escherichia coli 0157 :H7]

3099430 SEQ ID n~3517 sp|P37634] HIR_ECOLI HYPOTHΞTICAL 31.9 KD

PROTEIN IN PRLC-GOR INTERGENIC REGION (0280A)

Contig9 from pir||S47719 hypothetical 31.9K protein (prlC-gor

SEQ ID n° 8503 PL-687.1 3099526 to m 79% intergenic région^")^"- Escherichia coli 3100358 gb|AAB18475.l| (U00039) No définition line found

[Escherichia coli] gb|AAC76524.l| (AE000426) orf, hypothetical protein [Escherichia coli K12] SΞQ ID n~S516

Contig9 from SEQ ID n° 8504 PL-6359.1 3100289 to m No Hits found

3100441 #N/A Contig9 from gb|AAC32476.l| (AF044503) hep [Escherichia coli] SΞQ ID n° 8505 PL-3715.1 3101007 to 86% gb|AAG54535.l|AE005199_5 (AE005199) Z0266 gène

3101525 product [Escherichia coli 0157 :H7] SEQ ID n~2901 pir] [F82498 conserved hypothetical protein

Contig9 from VCA0107 [imported] - Vibrio cholerae SEQ ID n° 8506 PL-3714.1 3102426 to 71% (group 01 strain N16961) gb|AAF96021.l|

3102923 (AE004353) conserved hypothetical protein

[Vibrio cholerae] SEQ ID n~2900 pir| |G82498 conserved hypothetical protein

Contig9 from VCA0108 [imported] - Vibrio cholerae SEQ ID n° 8507 PL-686.1 3102947 to 84% (group 01 strain N16961) gb|AAF96022.1 |

3104425 (AΞ004353) conserved hypothetical protein

[Vibrio cholerae] SEQ ID n~3515 pir| |H82498 hypothetical protein VCA0109

Contig9 from

[imported] - Vibrio cholerae (group SEQ ID n° 8508 PL-6357.1 3104432 to 54%

01 Strain N16961) gb |AAF96023.1 | (AE004353)

3104872 hypothetical protein [Vibrio cholerae] #N/A

Contig9 from gb|AAG54529.l|AE005198_10 (AE005198) Z0260 gène SEQ ID n° 8509 PL-685.1 3104874 to 66% product [Ξscherichia coli 0157 :H7]

3106721 SEQ ID n~3514 Contig9 from gb|AAG54528.l|AE005198_9 (AE005198) Z0259 gène SEQ ID n° 8510 PL-684.1 3106757 to 64% product [Escherichia coli 0157 :H7]

3107737 SEQ ID n~3513

Contig9 from gb|AAG54527.l|AE005198_8 (AE005198) Z0258 gène

SΞQ ID n° 8511_ PL-683.1 3107743 to p 60% product [Escherichia coli 0157 :H7]

3109029 SΞQ ID n~3512

Contig9 from gb|AAG54526.l|AE005198_7 (AE005198) Z0257 gène

SEQ ID n° 8512 PL-3713.1 3109029 to p 603 product [Escherichia coli 0157 :H7]

3109595 SΞQ ID n~2899

Contig9 from gb|AAG54525.l|AE005198_6 (AE005198) Z0256 gène

SEQ ID n° 8513 PL-682.1 3109598 to p 683 product [Escherichia coli 0157 :H7]

3110950 SΞQ ID n~S511

Contig9 from gb|AAG54524.l|AE005198_5 (AE00519_8_Z0255 gène

SEQ ID n° 8514 PL- 681.1 3110950 to p ^"703 product [Escherichia coli 0157 :H7]

3111720 SΞQ ID n-3510

Contig9 from gb|AAG54523.1 |AΞ005138_4 (AE005198) putative

SEQ ID n° 8515 PL-680.1 3111731 to p 803 protease [Escherichia coli 0157 :H7]

3114376 SEQ ID n~3509

Contig9 from

SEQ ID n° 8516 PL-679.1 3114373 to No Hits found

3115173 SEQ ID n-3507

Contig9 from gb|AAG54522.l|AE005198_3 (AE005198) Z0253 gène

SEQ ID n° 8517 PL-678.1 3115170 to P 583 product [Ξscherichia coli 0157:H7]

3115817 SΞQ ID n~3506

Contig9 from gb|AAG54520.l|AΞ005198_l (AE005198) Z0251 gène

SEQ ID n° 8518 PL-677.1 3115823 to p 31% product [Escherichia coli 0157.-H7]

3117256 SΞQ ID n-3505

Contig9 from gb|AAG54519.l[AE005197_8 (AΞ005197) putative

SEQ ID n° 8519 PL-674.1 3117253 to p 683 macrophage toxin [Ξscherichia coli 0157:H7]

3120798 SEQ ID n~3503

Contig9 from gb|AAG54518.l|AE0051S7_7 (AE005137) Z0249 gène

SEQ ID n° 8520 PL-672.1 3120891 to p 58% product [Escherichia coli 0157 :H7]

3121607 SEQ ID n-3501

Contig9 from pdb|lF3l|A Chain A, Crystal Structure Of Tn5

SEQ ID n° 8521 PL-671.1 3121582 to m 573 Transposase Complexed With Transposon

3122964 End Dna SEQ ID n~3500

Contig9 from gb | AAG54518 . l | AE005197_7 (AE005197 ) Z0249 gène

SEQ ID n° 8522 PL-670.1 3123054 to p 46% product [Escherichia coli 0157 :H7]

3123731 SEQ ID n~3499

Contig9 from gb|AAC62387.l| (AF044506) VgrG protein

SEQ ID n° 8523 PL-669.1 3123813 to p 60% [Escherichia coli]

3125648 SΞQ ID n~3 97

Contig9 from gb|AAG54901.l|AE005236_2 (AE005236) Z0706 gène

SEQ ID n° 8524 PL-3709.1 3125696 to p 37% product [Escherichia coli 0157 :H7]

3126115 SEQ ID n~2894

-ContιgsT^~from gb|AAG54900.l]AE005236_l (AE005236) Z0705 gène

SEQ ID n° 8525 PL-667.1 3126137 to p 48% product [Escherichia coli 0157 :H7]

3130552 SEQ ID n~3495

Contig9 from

SEQ ID n° 8526

^"31.30537 to p No Hits found

3130872 #N/A

Contig9 from

SEQ ID n° 8527 PL-3705.1 3131440 to p No Hits found

3131991 SEQ ID n~2892

Contig9 from

SEQ ID n° 8528 PL-6340.1 3132095 to m No Hits found

3132292 #N/A

Contig9 from

SEQ ID n° 8529 PL-7143.1 3132412 to p No Hits found

3132561 #N/A

Contig9 from

SEQ ID n° 8530 PL-6339.1 3132583 to p No Hits found

3132963 #N/A

Contig9 from

SEQ ID n° 8531 PL-3704.1 3133434 to p No Hits found

3133661 SEQ ID n~2891

Contig9 from

SEQ ID n° 8532 PL-666.1 3133968 to p No Hits found

3134675 SΞQ ID n~3494

ContigS from dbj |BAB06239.l| (AP001515) transposase related

SEQ ID n° 8533 PL-665.1 3134874 to m 21% protein (20) [Bacillus halodurans]

31358S9 SEQ ID n~3493

Contig9 from

SEQ ID n° 8534 PL-7142.1 3136340 to p No Hits found

3136507 #N/A

pir| |C69899 conserved hypothetical protein yobL •

Bacillus subtilis gb|AAB84464.1 |_ (AF027868)

Contig9 from

Topl homolog [Bacillus subtilis] -SEQ—I-D-n° 8535 PL-6337.1 3137012 to -34%- emb|CAB13792. ι| (Z99114) similar to hypothetical

3137371 proteins from B. subtilis [Bacillus subtilis] #N/A pir| |B59899 hypothetical protein yobK - Bacillus

Contig9 from subtilis gb| AAB84463. l| (AF027868) spore coat

SEQ ID n° 8536 PL-3703.1 3137508 to 47% protein [Bacillus subtilis] emb[CAB13791.l|

3137S78

(Z99114) yobK [Bacillus subtilis] SEQ ID n-2890

Contig9 from^"

SEQ ID n° 8537 PL-6336.1 3138260 to No Hits found

3138502 #N/A

Contig9 from

SEQ ID n^» 8538 PL-664.1 3138580 to m No Hits found

3139899 SEQ ID n~3492 sp ( PO918 |VSR_EC0LI .VERY SHORT PATCH REPAIR PROTEIN (DNA MISMATCH ENDONUCLEASE) (VSR MISMATCH ENDONUCLEASE) (V.ECOKDCM) pir[ (JS0264

DNA mismatch endonuclease vsr (EC 3.1.-.-) -

Escherichia coli emb] CAA31707. l| (X13330) ORF 2

Contig9 from

(AA 1 - 156) [Escherichia coli] gb|AAA03724.l|

SEQ ID n° 8539 PL-3702.1 3140097 to m 743

(M32307) pot. patch repair protein [Escherichia

3140570 coli] dbj |BAA15787.l| (D90835) Patch repair protein (DNA mismatch endonuclease) (EC

3.1.-.-) [Escherichia coli] gb] AAC75026.l|

(AE000287) DNA mismatch endonuclease, patch repair protein [Escherichia coli K12] SEQ ID n~2889 sp|P0510l|MTE2_ΞCOLI MODIFICATION MΞTHYLASE

ECORII (CYTOSINΞ-SPΞCIFIC MΞTHYLTRANSFΞRASΞ

Contig9 from ECORII) (M. ECORII) pir] |XYECR2 site-specific

SEQ ID n° 8540 PL-663.1 3140578 to m 81% DNA-methyltransferase (cytosine-specific) (EC

3142014 2.1.1.73) EcoRII - Escherichia coli (strain

HB101) emb|CAA28725.l| (X05050) EcoRII cytosine methylase (AA 1-477) [Ξscherichia coli] SΞQ ID n~S491

Contig9 from gb|AAG54520.l|AE005198_l (AE005198) Z0251 gène SEQ ID n° 8541 PL-662.1 3142116 to 51% product [Escherichia coli 0157 :H7] 3142799 SEQ ID n~3490

Contig9 from gb|AAG54519.l|AE005197_8 (AE005197) putative SΞQ ID n° 8542 PL-660.1 3142796 to 683 macrophage toxin [Escherichia coli 0157 :H7]

3146341 SΞQ ID n~3489

Contig9 from gb]AAG54518.l|AΞ005197_7 (AΞ005197) Z0249 gène SΞQ ID n° 8543 PL-658.1 3146437 to 57% product [Ξscherichia coli 0157 :H7]

3147330 ^ SΞQ ID n~3486 Contig9 from pdb[lF3l|A Chain A, Crystal Structure of Tn5 SEQ ID n° ^""8544 PL-657.1 3147341 to 573 ^""Transposase Complexed With Transposon

3148723 End Dna SΞQ ID n~3485 sp|P42296|YXID_BACSU HYPOTHETICAL 64.3 KD

PROTEIN IN HUTP-BGLP INTERGENIC REGION

Contig9 from pir| |H70076 hypothetical protein J3D [imported] SΞQ ID n° 8545 PL-3700.1 3149120 to 36% Bacillus subtilis dbj |BAA06649. l| (D31856)

3149554 hypothetical protein [Bacillus subtilis] emb|CAB15966.l| (Z99124) yxiD [Bacillus subtilis] SΞQ ID n~2888

Contig9 from SΞQ ID n° 8546 PL-3699.1 3149556 to p No Hits found

3150035 SΞQ ID n~2885 Contig9 from SEQ ID n° 8547 PL-656.1 3150341 to p No Hits found

3151048 SΞQ ID n~3484 Contig9 from SEQ ID n° 8548 PL-6324.1 3151774 to p No Hits found

3151917 #N/A ContigS from SEQ ID n° 8549 PL-3698.1 3152035 to p No Hits found

3152529 SΞQ ID n~2884 Contig9 from gb|AAC26596.1] (U83995) putative protease SEQ ID n° 8550 PL-655.1 3152687 to p 59% [Porphyromonas gingivalis]

3153571 SΞQ ID n~S483

Contig9 from

SEQ ID n° 8551 PL-6323.1 3153810 to No Hits found

3154202 #N/A

Contig9 from dbj |BAB06239.l| (AP001515) transposase related

SEQ ID n° 8552 PL-654.1 3154721 to m 21% protein (20) [Bacillus halodurans]

3155746 SΞQ ID n~3482

Contîg9 from

SEQ ID n° 8553 PL-6321.1 3155838 to No Hits found

3156191 #N/A

Contig9 from

SEQ ID n° 8554 PL-7141.1 ^~ 3156790 to No Hits found

3156957 #N/A

Contig9 from

SEQ ID n° 8555 PL-6320.1 3157445 to m No Hits found

3157642 #N/A

Contig9 from

SEQ ID n° 8556 PL-6318.1 3157656 to m No Hits found

3157790 #N/A

Contig9 from gb|AAG56610.l|AΞ005386_l (AE005386) PTS System,

SEQ ID n° 8557 PL-6317.1 3157818 to 72% maltose and glucose-specific II ABC

3158165 [Escherichia coli 0157 :H7] #N/A

Sp|P07026|SDIA_ECOLI SDIA REGULATORY PROTEIN pir| IQQΞCUI probable transcription regulator

Contig9 from sdiA - Escherichia coli dbj |BAA15736.1 | SΞQ ID n° 8558 PL-653.1 3158595 to 45% (D90832) SdiA regulatory protein. [Ξscherichia

3159323 coli] gb|AAC74983.1 | (AE000284) transcriptional regulator of ftsQAZ gène cluster

[Ξscherichia coli K12] SEQ ID n~3481

Contig9 from gb|AAG00942.l|AF272977_2 (AF272977) transposase SEQ ID n° 8559 PL-652.1 3159745 to 29% [Mycoplasma hyopneumoniae]

3161361 SEQ ID n~3480 Contig9 from gb|AAC45946.l| (AF021840) AidA [Ralstonia SΞQ ID n° 8560 PL-3697.1 3161611 to 46% solanacearum]

3162201 SEQ ID n~2883

sp]P1532l]HLYB_SΞRMA HEMOLYSIN ACTIVATOR PROTEIN

Contig9 from

PRECURSOR pir| |B28182 hemolysin B - Serratia SEQ ID n° 8561 PL-651.1 3162870 to 763 marcescens gb| AA50322.1 | (M22618) hemolysin 3164537 déterminant [Serratia marcescens] SΞQ ID n~3479

C SEQ_ID_n£_8-562 PL-650.1 SEQ ID n~3478

Contig9 from SΞQ ID n° 8563 PL-3695.1 3169384 to No Hits found 3169932 SΞQ ID n~2882

Conti g 9 from gb|AAG48301.l|AF310136_l (AF310136) TnlO SEQ ID n° 8564 PL-649.1 3170280 to 503 transposase [Plaspoεon NKBOR]

3170858 SEQ ID n~3476 ref |NP_0530S0.1] orf28 [Escherichia coli] gb|AAB36834.l| (L42638) orf5 ; open reading frame

Contig9 from with no significant homology tq. any SEQ ID n° 8565 PL-648.2 3170859 to 583 proteins in the database [Ξscherichia coli]

3171569 dbj |BAA84863.l| (AB024946) orf28 [Eschenchia coli] SEQ ID n~3475 dbj |BAB03895.1 | (AP001507) transposase (09)

[Bacillus halodurans] dbj [BAB03988.1]

(AP001507) transposase (09) [Bacillus halodurans] dbj |BAB05361. l| (AP001512) transposase (09) [Bacillus halodurans] dbj |BAB05614.l] (AP001513) transposase (09)

Contig9 from

[Bacillus halodurans] dbj |BABO6561.1 | SΞQ ID n° 8566 PL-3694.1 3171600 to 733

(AP001516) transposase (09) [Bacillus

3172055 halodurans] dbj |BAB0695 . l| (AP001518) transposase (09) [Bacillus halodurans] dbj |BABO7185.1 | (AP001518) transposase ( 09 )

[Bacillus halodurans] dbj |BAB07197.l|

(AP001518) transposase (09) [Bacillus halodurans] SEQ ID n~2881

pir| [F81045 hemagglutinin/hemolysin-related protein NMB1768 [imported] -

Contig9 from

Neisseria meningitidis (group B strain MD58)

SΞQ ID n° 8567 PJ.--64-7-.-1 3-1-7-2203 to 223 gb]AAF4^"2109.l| (AE002526)

3173597 hemagglutinin/hemolysin-related protein

[Neisseria meningitidis MC58] SEQ ID n~3474

^"^ Contig9 from dbj |BAB06239.l| (AP001515) transposase related SΞQ ID n° 8568 PL-646.1 3173998 to 223 protein (20) [Bacillus halodurans]

3175050 SEQ ID n~3473 Contig9 from SEQ ID n° 8569- Prr~-7139.1 3175236 to No Hits found ^"

3175427 #N/A Contig9 from gb|AAG58663.l|AΞ005577_8 (AΞ005577) orf, SEQ ID n° 8570 PL-644.1 3175578 to 723 hypothetical protein [Ξscherichia coli 0157.-H7]

3176570 SEQ ID n~3471 sp|P45418 | YKDK_ΞRWCH HYPOTHETICAL 8.1 KD PROTEIN

_IN KDGK 5 'REGION (K2 ORF) pir] |B55215 4-

Contig9 from oxalocrotonate tautomerase (EC 5.3.2.-) SEQ ID n° 8571 PL-6315.1 3176626 to 583

[similarity] - Erwinia chrysanthemi

3176832 emb|CAA52960.l[ (X75047) K2 ORF [Ξrwinia chrysanthemi] #N/A

Contig9 from gb|AAG58668.l|AE005578_5 (AE005578) orf, SEQ ID n° 8572 PL-643.1 3176876 to 67% hypothetical protein [Ξscherichia coli 0157 :H7]

3178366 SEQ ID n~3470 sp]P37649|YHJK_EC0LI PROTEIN YHJK pir||S47750 hypothetical protein (dctA-dppF intergenic

Contig9 from région) - Ξscherichia coli SEQ ID n° 8573 PL-642.1 3178545 to m 61% gb|AAB18506.l| (U00039) No définition line found

3179258

[Escherichia coli] gb| AAC76554.l| (AE000429) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~3469

Contig9 from gb |AAG58684. l| AEO 05580_6 (AE005580) putative ATP SEQ ID n° 8574 PL- 641.1 3179615 to m 84% binding component of dipeptide transport

3180595 system [Ξscherichia coli 0157 :H7] SΞQ ID n-3468

sp|P37314|DPPD_ECOLI DIPEPTIDΞ TRANSPORT ATP- BINDING PROTBIN DPPD pir| |S61404 dipeptide transport protein dppD - Ξscherichia coli gb|AAA23705.l| (L08399) peripheral membrane protein [Ξscherichia coli] gb] AAB18519. l|

Contig9 from

(U00039) dppD [Bscherichia coli] gb| AAC76566.1 |

-SEQ ID n° 8575 PL-640.1 3180631-tp—. -m_ -9-0%

(AE000431) putative -ATP-binding^"" component of 3181611 dipeptide transport system

[Escherichia coli K12] gb] AAG58685.1 j AΞ005580_7

(AΞ005580) putative ATP-binding component of dipeptide transport^" system

[Escherichia coli 0157 :H7] SEQ ID n~3467 sp[P37315|DPPC_ΞCOLI DIPEPTIDE TRANSPORT SYSTΞM

PERMEASE PROTEIN DPPC pir] |S47764 dipeptide transport system permease protein dppC -

Escherichia coli gb| AAA23704.l| (L08399)

Contig9 from_. transmembrane protein [Escherichia coli]

SEQ ID n° 8576 PL-639.1 3181624 to i73 gb |AAB18520. l| (U00039) dppC [Escherichia coli]

3182523 gb|AAC76567.l[ (AE000431) dipeptide transport system permease protein 2

[Escherichia coli K12] gb| AAG58686.1 |AE005580_8

(AE005580) dipeptide transport System permease protein 2 [Escherichia coli 0157 :H7] SΞQ ID n~3465 sp|P37316]DPPB_BCOLI DIPEPTIDE TRANSPORT SYSTEM

PERMEASE PROTEIN DPPB pir | [S47765 dipeptide transport system permease protein dppb -

Escherichia coli gb| AAA23703.l| (L08399)

Contig9 from transmembrane protein [Escherichia coli]

SEQ ID n° 8577 PL-638.1 3182534 to 923 gb] AAB18521.l| (U00039) dppB [Ξscherichia coli]

3183553 gb|AAC76568.l| (AΞ000431) dipeptide transport system permease protein 1

[Escherichia coli K12] gb|AAG58687. l|AE005580_9

(AEO 05580) dipeptide transport system permease protein 1 [Escherichia coli 0157 :H7] SEQ ID n~3464

sp|P23847|DPPA_ΞCOLI PΞRIPLASMIC DIPΞPTIDΞ

TRANSPORT PROTEIN PRECURSOR

(DIPEPTIDΞ-BINDING PROTEIN) (DBP) pir||A39194 periplasmic dipeptide transport protein precursor dppA - Escherichia coli

Contig9 from emb|CAA410S0.l| (X58051) dipeptide binding

SEQ ID n°^"~8378 PL-637.1 3183672 to 84% protein (DBP) [Bscherichia coï ]

3185279 gb| AAA23707.l| (M35045) dipeptide transporter protein [Ξscherichia coli] gb|AAA23702. l[

(L0839S) dipeptide-binding protein [Escherichia coli] gb|AABl8522.l| (U0003S) dppA^" [^"Escherichia coli] gb|AAC76569.l| (AE000431) dipeptide transport protein [Escherichia coli K12] SEQ ID n~3463

Contig9 from gb|AAG61057.l|AF322013_176 (AF322013) ID870

SEQ ID n° 857S PL-636.1 3185882 to m 463 [Bradyrhizobium japonicum]

3186802 SEQ ID n~3462

Sp|P37887|CYSK_BACSU CYSTEINE SYNTHASE_ (0-

ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSΞRINΞ

(THIOL) -LYASE) (CSASE) (SUPEROXIDE-INDUCIBLE

Contig9 from PROTEIN 11) (SOI11) pir] |S66103

SEQ ID n° 8580 PL-6312.1 3186781 to 34% cysteine synthase (EC 4.2.99.8) A - Bacillus

3187110 subtilis dbj |BAA05308.l| (D26185) cysteine synthetase A [Bacillus subtilis] emb|CAB11849.l| (Z99104) cysteine synthetase A

[Bacillus subtilis] #N/A pir] |A70044 conserved hypothetical protein yvmC

Bacillus subtilis gb |AAC67279.1 | (AF017113)

Contig9 from YvmC [Bacillus subtilis] emb|CABl5512. l|

SΞQ ID n° 8581 PL-635.1 3187553 to 51% (Z99121) similar to hypothetical proteins

3188257 [Bacillus subtilis] emb | CAB15524.1 | (Z99122) similar to hypothetical proteins [Bacillus subtilis] SEQ ID n~S461

sp| 034926 |CYPX_BACSU PUTATIVE CYTOCHROME P450

CYPX pir | |F69611- cytochrome P450 cypX -

Contig9 from Bacillus subtilis gb|AAC67280. l| (AF017113) SEQ ID n° 8582 PL-634.1 3188343 to 64% CypB [Bacillus subtilis] emb|CAB15511.1 |

3189566 (Z99121) cytochrome P450-like enzyme [Bacillus subtilis] emb|CAB15523.l| (Z99122) cytochrome

P450-like enzyme [Bacillus subtilis] SΞQ ID n~3460

Contig9 from SEQ ID n° 8583 PL-7138.1 3189707 to p No Hits found

3189835 #N/A Contig9 from ref |NP_053144.l| ORF11 [Yersinia pestis] SEQ ID n° 8584 PL-6311.1 3189909 to m 763 gb|AAF05107.l|AF152923_ll (AF152923) ORF11

3190073 [Yersinia pestis] #N/A sp P0096l|SYGB_ECOLI GLYCYL-TRNA SYNTHETASE BETA

CHAIN (GLYCINE--TRNA LIGASE BETA CHAIN)

(GLYRS) pir| |SYECGB glycine--tRNA ligase (EC

Contig9 from

6.1.1.14) beta chain - Escherichia coli SEQ ID n° 8585 PL-633.1 3190184 to 893 gb|AAB18536.l| (U00039) glycine-tRNA synthetase,

3192253 beta subunit [Escherichia coli] gb| AAC76583.1 |

(AE000433) glycine tRNA synthetase, beta subunit

[Ξscherichia coli K12] SEQ ID n~3459

Contig9 from gb|AAG58708.l|AΞ005582_ll (AE005582) glycine SEQ ID n° 8586 PL-632.1 3192263 to m 85% tRNA synthetase, alpha subunit [Escherichia coli

3193177 0157 :H7] SEQ ID n~3458

sp | O5100 | 3MG1_EC0LI DNA-3 -METHYLADΞNINE

GLYCOSYLASE I (3-METHYLADENINE-DNA GLYCOSYLASE

I, CONSTITUTIVE) (TAG I) (DNA-3 -MΞTHYLADENINE

GLYCOSIDASΞ I) pir| | DGECMl 3-methyladenine-DNA glycosylase (EC 3.2.2.-) I - Escherichia coli Contig9 from emb|CAA27472.l| (X03845) TAGI (aa 1-187)

^"SEQ ID n° 8587 PL-3693.1 31S3374 to 74% [Escherichia coli] gb|AAA24^~658. l| (J02606) 3-

3133946 methyladenine-DNA glycosylase I (tag)

[Escherichia coli] gb |AAB18526. l| (U00039) 3- methyladenine DNA glycosylase I, constitutive

[Escherichia coli] gb | AC76573.1 | (AEO 00432) 3- methyl- denine DNA glycosylase I, constitutive

[Escherichia coli K12] SΞQ ID n~2880 gb|AAG58721.l|AE005584_3 (AE005584) alanine-

Contig9 from alpha-ketoisovalerate (or valine-pyruvate) SEQ ID n° 8588 PL-631.1 3194152 to 82% transaminase, transaminase c [Escherichia coli

3195405

0157 :H7] SEQ ID n~3457

Contig9 from SEQ ID n° 8589 PL-6309.1 3195624 to No Hits found

3195746 #N/A Contig9 from gb|AAG58890.l|AΞ005600_8 (AE005600) yidQ gène SEQ ID n° 8590 PL-3692.1 3196158 to 403 product [Ξscherichia coli 0157 :H7]

3196613 SΞQ ID n~2879 sp]P31455|YIDR_ΞC0LI HYPOTHΞTICAL 46.4 KD

PROTEIN IN IBPA-GYRB INTERGENIC REGION

Contig9 from pir] |B65171 hypothetical protein yidR - SEQ ID n° 8591 PL-630.1 3196676 to 703

Escherichia coli (strain K--12) gb | AAC76712.11

3197965

(AE000446) orf, hypothetical protein

[Escherichia coli K12] SEQ ID n~3456

Contig9 from gb|AAG58790.1JAE005592_l (AE005592) orf, SEQ ID n° 8592 PL-629.1 3198099 to 74% hypothetical protein [Escherichia coli 0157 :H7]

3198716 SEQ ID n~3454 Contig9 from sp]P25772|YICF_ECOLI HYPOTHETICAL 63.2 KD SEQ ID n° 8593 PL-628.1 3198710 to 50% PROTEIN IN RPH-GMK INTERGENIC REGION

3200452 SEQ ID n~3453

Contig9 from SΞQ ID n° 8594 PL-6307.1 .3200953 to p No Hits found

3201042 #N/A pir| |C82602 hypothetical protein XF2068

Contig9 from [imported] - Xylella fastidiosa SΞQ ID n° 8595 PL-3691.1 3201104 to p 40% (strain 9a5c) gb | AF84867.l| Ξ004023_3 ^{: :} 3201559 (AE004023) hypothetical protein [Xylella ^{" "} fastidiosa] SEQ ID n~2878

Contig9 from ref |NP_052451.l| yacB [Plasmid ColIb-P9]

SEQ ID n° 8596 PL-6305.1

C

SΞQ ID n° 8597 PL-6304.1

Contig9 from

SΞQ ID n° 8598 -PL-7137.1 3202485 to p No Hits found

Contig9 from

SΞQ ID n° 8599 PL-627.1 3203447 to p No Hits found

3204106 SEQ ID n~3452

Contig9 from

SEQ ID n° 8600 PL-7136.1 3204997 to m No Hits found

3205383 #N/A

Contig9 from

SEQ ID n° 8601 PL-626.1 3205458 to p No Hits found

3206198 SEQ ID n~3451

Contig9 from

SEQ ID n° 8602 PL-625.1 3206736 to p No Hits found

3207425 SEQ ID n~3450

Contig9 from gb|AAF50913.2| (AE003571) HERC2 gène product

SEQ ID n° 8603 PL-623.1 3208192 to p 27% [Drosophila melanogaster]

3209415 SEQ ID n~3448

Contig9 from

SEQ ID n° 8604 PL-6300.1 3209500 to m No Hits found

3209676 #N/A

Contig9 from gb(AAF50913.2| (AE003571) HERC2 gène product SEQ ID n° 8605 PL-622.1 3209652 to 21% [Drosophila melanogaster]

3210947 SEQ ID n~3447

ContigS from emb|CAB41498.l| (AJ238399) hypothetical

SEQ ID n° 8606 PL-6298.1 3211027 to 543 transposase [Escherichia coli]

3211239 #N/A

Contig9 from

SEQ ID n° 8607 PL-6297.1 3211357 to m No Hits found

3211518 #N/A sp]P24234|KGUAJECOLI GUANYLATE KINASE (GMP KINASE) pirï^"|^~KTECGU guanylate kinase (EC

Contig9 from 2.7.4.8) - Escherichia coli gb| AAB88711.l|

SEQ ID n° 8608 PL-6 1.1 3211648 to 79% (M84400) GMP kinase [Escherichia coli]

3212271 gb|AAA62001.l| (L10328) 5'guanylate kinase

[Escherichia coli] gb]AAC76672.l| (AΞ000442) guanylate kinase [Ξscherichia coli K12] SEQ ID n~3446 sp|P08374|RPOZ_ECOLI DNA-DIRECTED RNA POLYMERASE OMEGA CHAIN (TRANSCRIPTASΞ OMΞGA CHAIN) (RNA POLYMERASE OMEGA SUBUNIT) pir] ] RNECO DNA- directed RNA polymerase (EC 2.7.7.6) oméga chain - Escherichia coli gb|AAA24229.l[

(M15266) oméga protein [Escherichia coli]

Contig9 from gb]AAB00159.l| (M24503) oméga protein SEQ ID n° 8609 PL-6296.1 3212326 to 78% [Escherichia coli] gb| AAA62002. l| (L10328) RNA

3212601 polymerase oméga subunit [Escherichia coli] gb|AAC76673.l| (AE000442) RNA polymerase, oméga subunit [Ξscherichia coli K12] gb|AAG58793.l|AE005592_4 (AΞ005592) RNA polymerase, oméga subunit [Escherichia coli

0157 : H7] #N/A

sp | P17580 | SPOT_ECOLI GUANOSINE-3 ' , 5 ' -

BIS (DIPHOSPHATB) 3 ' -PYROPHOSPHOHYDROLAΞE

(( PPGPP) ASE) (PENTA-PHOSPHATE

GUANOSINΞ-3 ' -PYROPHOSPHOHYDROLASΞ) pir | SHECGD guanosine 3 ' , 5 ' -bis (diphosphate) 3¹ pyrophosphatase (ΞC 3.1.7.2) -

Escherichia coli gb|AAA62003.l| (L10328)

(p)ppGpp 3 ' -pyrophosphohydrolase [Escherichia

Contig9 from coli] gb|AAB00160.l| (M24503) (p)ppGpp 3'-

SΞQ ID n° 8610 PL-620.1 3212619 to 883 pyrophosphohydrolase [Escherichia coli]

3214736 gb|AAC76674.l| (AE000442) (p) ppGpp^~"synthetase

II; also guanosine-3 ' , 5' -bis pyrophosphate 3 ' -pyrophosphohydrolase

[Escherichia coli K12] gb|AAG58794.l|AE005592_5 (AE005592) (p)ppGpp synthetase II; also guanosine-3 ' , 5 ' -bis pyrophosphate 3 ' -pyrophosphohydrolase

[Escherichia coli 0157:H7] SEQ ID n~3445

Contig9 from

SΞQ ID n° 8611 PL-3690.1 3214668 to m No Hits found

3215159 SEQ ID n~2877 ref |NP_073234.l| orf10 [Salmonella enterica

Contig9 from serovar Choleraesuis] dbj ]BAB20517. l|

SEQ ID n° 8612 PL-3689.1 3215174 to 313

(AB040415) orflO [Salmonella enterica serovar

3215674

Choleraesuis] SEQ ID n~2875

Contig9 from

SEQ ID n° 8613 PL-619.1 3215806 to m No Hits found

3217131 SΞQ ID n~3443 sp|P30130 |FIMD_ECOLI OUTER MEMBRANE USHΞR

PROTΞIN FIMD PRΞCURSOR pir]|S56542 outer membrane usher protein fi D precursor -

Contig9 from

Escherichia coli gb| AA97213.1 | (U14003) CG SEQ ID n° 8614 PL-618.1 3217300 to 543

Site No. 18349 [Escherichia coli]

3219930 gb|AAC77273.l| (AE000502) outer membrane protein; export and assembly of type 1 fimbriae, interrupted [Ξscherichia coli K12] SEQ ID n~3442

Contig9 from gb|AAG55424.l|AE005284_2 (AE005284) putative

SEQ ID n° 8615 PL- 617.1 3220114 to 473 chaperone [Escherichia coli 0157 :H7]

3220308 SEQ ID n~3441

Contig9 from gb|AAG59498.l|AE005662_10 (AE005662) periplasmic

SEQ ID n° 8616 PL-616.1 3220945 to 503 chaperone, required for type 1 fimbriae

3221664 [Ξscherichia coli 0157 :H7] SΞQ ID n~3440

Contιg9 from

SEQ ID n° 8617 PL-615.1 3221745 to m No Hits found

3222401 SEQ ID n~3439

Contig9 from

SEQ ID n° 8618 PL-614 I^" - 3222491 to No Hits found

3223213 SEQ ID n~3438

Contig9 from

SEQ ID n° 861S PL-613.1 3223281 to m No Hits found

3223853 #N/A

Contig9 from gb|AAG58694.l|AE005581_6 (AE005581) putative

SEQ ID n° 8620 PL- 612.1 3223891 to 45% fimbrial chaperone [Escherichia coli 0157 :H7]

3224631 SEQ ID n~3437

Contig9 from gb|AAB41914.l| (U31413) FotA precursor

SEQ ID n° 8621 PL-611.1 3224758 to m 36% [Escherichia coli]

3225363 SEQ ID n~3436 sp|P04742|FIMB_ΞCOLI TYPE 1 FIMBRIAE REGULATORY

PROTEIN FIMB pir||S56537 recombinase fimB

(involved in phase variation) - Ξscherichia coli pir||RGECFF type 1 fimbriae regulatory protein fimB - Escherichia coli gb [AAA97208. l| (U14003)

Contιg9 from recombinase involved in phase variation

SEQ ID n° 8622 PL-610.1 3225789 to m 703 [Escherichia coli] gb]AAC77268.l| (AE000502)

3226355 recombinase involved in phase variation; regulator for fi A [Escherichia coli

K12] gb|AAG59494.l|AΞ005662_6 (AE005662) recombinase involved in phase variation; regulator for fimA [Escherichia coli

0157 :H7] SEQ ID n~3435

gb|AAG58796.l|AΞ005592_7 (AE0055S2) DNA

Contig9 from helicase, resolution of Holliday junctions,

SEQ ID n° 8623 PL-609.1 3226767 to 863 branch migration [Escherichia coli

3228878

0157 :H7] SEQ ID n~3433

Contig9 from

SEQ ID n° 8624 PL-6289.1 3

ContigS from

SEQ ID n° 8625 PL-6288.1 322SS06 to No Hits found

3230166 #N/A

Contig9 from^"

SEQ ID n° 8626 PL-6287.1 3230826 to No Hits found

3231041 #N/A

Contig9 from gb|AAC84004.l| (AF072126) stability protein StbE

SEQ ID n° 8627 PL-6286.1 3231155 to 74% [Morganella morganii]

3231445 #N/A sp|P07007|RΞLB_ECOLI RELB PROTEIN pir|[BVBCRB relB protein - Escherichia coli emb | CAA26250.1 |

(X02405) relB protein (aa 1-79) [Ξscherichia

Contig9 from coli] dbj |BAA15263.l] (D90798) RelB protein SEQ ID n° 8628 PL-6285.1 3231435 to m 51% [Escherichia coli] dbj |BAA15273.l| (D90799)

3231689 RelB protein [Ξscherichia coli] dbj |BAA15295.1 |

(D90800) RelB protein [Bscherichia coli] gb|AAC74637.l| (AE000253) négative regulator of translation [Ξscherichia coli K12] #N/A pir| |C81019 hypothetical protein NMB1983

[imported] - Neisseria meningitidis

Contig9 from (group B strain MD58, group A strain Z2491)

SEQ ID n° 8629 PL-608.1 3232096 to m 39% gb|AAF4231l.l] (AE002547) hypothetical protein

3232863 [Neisseria meningitidis MC58] emb|CAB83756.l|

(AL162753) hypothetical protein [Neisseria meningitidis Z2491] SEQ ID n~3432

pir| |B82474 hypothetical protein VCA0312 VCA0386 [imported] - Vibrio cholerae (group 01 Contig9 from strain N16961) gb | AC38426.11 (AF055586)

SEQ ID n° 8630 PL-6283.1 3233779 to 423 unknown [Vibrio cholerae] gb|AAF96220.1 |

3234048 (AE004370) hypothetical protein [Vibrio cholerae] gb| AAF9629 . l| (AE004374) hypothetical protein [ ibrio cholerae] #N/A pir| |F82466 conserved hypothetical protein

VCA0385 VCA0311 [imported] - Vibrio

Contig9 from cholerae (group 01 strain N16961) SEQ ID n° 8631-PL-6282.1 3234051 to 35% gb|AAF96219.l| (AE004370) hypothetical protein

3234458

[Vibrio cholerae] gb|AAF96291.l| (AE004374) conserved hypothetical protein [Vibrio cholerae] #N/A

Contιg9 from dbj |BAAS2862.l| (AB040403) TRP-1 [Burkholderia SΞQ ID n° 8632 PL-607.1 3234734 to 603 glumae]

3235477 SEQ ID n~3431 Contig9 from SEQ ID n° 8633 PL-6281.1 3236121 to m No Hits found

3236345 #N/A sp|PlS933 |GLTS_ECOLI SODIUM/GLUTAMATΞ SYMPORT

CARRIER PROTEIN (GLUTAMATE PERMΞASE) pir((si4031 gtlS protein - Escherichia coli pιr| |Y0ECNQ sodium--glutamate symport carrier protein - Escherichia coli emb | CAA35540.l|

(X17499) gltS protein [Escherichia coli]

Contig9 from gb|AAA62006.1 | (L10328) glutamate permease

SEQ ID n° 8634 PL-606.1 3236589 to 89%

[Escherichia coli] gb] AAC76677.1 | (AE000442)

3237797 glutamate transport [Escherichia coli K12] emb|CAA06472.l| (AJ005325) glutamate permease

[synthetic construct] emb]CAA06475.l]

(AJ005328) glutamate permease [synthetic construct] emb|CAA06485. l| (AJ005339) glutamate permease [synthetic construct] SEQ ID n~3430

sp|P27432 |YICE_ECOLI PUTATIVE PURINE PERMΞASΞ

YICE pir| |H65166 hypothetical 48.9 kD protein in gltS 3 ' région - Escherichia coli

Contig9 from (strain K-12) gb|AAA62007. l| (L10328) o463

SΞQ ID n° 8635 PL-605.1 3238040 to 863 [Escherichia coli] gb| AAC76678.1 | (AE000443)

3239425 putative transport protein [Escherichia coli

K12] gb|AAG5^"8799.l|AE005593_l (AE005593) putative transport protein [Escherichia coli

0157 :H7] SEQ ID n~3429

Contιg9 from gb |AAC38324._1.| (AF031325) phénol hydroxylase

SEQ ID n° 8636 PL-604.1 3~239634 to m 70%

[Bacillus thermoleovorans]

3241187 SEQ ID n~3428 sp|P31433|YICH_ECOLI HYPOTHΞTICAL 62.3 KD

PROTEIN IN GLTS-SELC INTERGENIC REGION

Contig9 from pir] ]A65167 hypothetical 62.3K protein (gltS-

SEQ ID n° 8637 PL-603.1 3241659 to 55% selC région) - Escherichia coli

3243365

(strain K-12) —gb[AAC76679.1 | (AE000443) orf, hypothetical protein [Ξscherichia coli K12] SEQ ID n~3427 pir[ (F69044 mutator MutT protein homolog -

Me hanobacterium thermoautotrophicum

ContigS from

(strain Delta H) gb|AAB858l4.l | (AE000897) SEQ ID n° 8638 PL-6280.1 3243536 to 443 mutator MutT protein homolog

3243S58

[Methanother obacter thermautotrophicus] #N/A sp|P32148 JYIID_EC0LI HYPOTHETICAL 37.1 KD

PROTEIN IN RBN-FDHE INTERGENIC REGION (0329) pir] |S40832 hypothetical 37. IK protein (glnA-

Contig9 from fdhE intergenic région) - Escherichia

SEQ ID n° 8639 PL-602.1 3243996 to 803 coli gb|AAB03021.l| (L19201) ORF_o32S

3244913

[Escherichia coli] gb| AAD13450.l| (AE000464) putative acetyltransferase (EC 2.3.1.18)

[Escherichia coli K12] SEQ ID n~3426

sp|P32147|YIHZ_ECOLI HYPOTHΞTICAL 15.9 KD

PROTΞIN IN RBN-FDHΞ INTΞRGΞNIC RΞGION (0145) pir| |S40831 hypothetical 15.9K protein (glnA-

Contig9 from fdhΞ intergenic région) - Escherichia SΞQ ID n° 8640 PL-6278.1 3244986 to m 85% coli gb|AAB03020.l| (L19201) 0RF_ol45

3245423 _^[Escherichia coli] gb| AAD13449.l| (AΞ000464) orf, hypothetical protein [Escherichia coli K12] gb|AAG59077.l|AΞ005619_10 (AE005619) orf, hypothetical protein [Escherichia coli 0157 :H7] #N/A

Contig9 from gb | AAG59075.11 AΞ005619_8 (AΞ0.0.5.619.)..putative

SΞQ ID n° 8641 PL-601.1 3245467 to 68% phosphatase [Escherichia coli 0157 :H7]

3246093 SEQ ID n~3425

Contig9 from gb|AAK02216.l| (AΞ006048) unknown [Pasteurella

SEQ ID n° 8642 PL-600.1 3246250 to 77% multocida]

3247704 SEQ ID n~3424

Contig9 from emb] CAB56502.1 | (AJ249744) putative membrane

SEQ ID n° 8643 PL-599.1 3248759 to 41% protein CjaE [Campylobacter jejuni]

3249328 SEQ ID n~3421 emb]CAC20136.l| (AJ278218) BipA protein

Contig9 from

[Escherichia coli] gb | AAG59060.1 | AE005618_1

SEQ ID n° 8644 PL-598.1 3249391 to m 923

(AΞ005618) putative GTP-binding factor

3251211

[Escherichia coli 0157:H7] SEQ ID n~S420

Contig9 from

SEQ ID n° 8645 PL-6275.1 3251333 to m No Hits found

3251566 #N/A sp | 28786 | GLNA_PROVU GLUTAMINE SYNTHETASE

Contig9 from (GLUTAMATΞ--AMMONIA LIGASΞ) pir||S23899 SEQ ID n° 8646 PL-596.1 3251671 to 86% glutamate--ammonia ligase (ΞC 6.3.1.2) - Proteus

3253080 vulgaris emb|CAA48234 ,l| (X68129) glutamate-- ammonia ligase [Proteus vulgaris] SΞQ ID n~3418 sp|P06218|NTRB_KLΞPN NITROGEN REGULATION PROTEIN

Contig9 from NTRB pir| |A24114 nitrogen régulation protein II SEQ ID n° 8647 PL-595.1 3253234 to 833 (EC 2.7.3.-) ntrB - Klebsiella

3254283 pneumoniae emb] CAA26923.1 | (X03146) ntrB protein (aa 1-349) [Klebsiella pneumoniae] SEQ ID n~3417

sp|P41789|NTRC_SALTY NITROGEN REGULATION PROTEIN

Contig9 from NR(I) pir| |S53024 nitrogen régulation protein I SEQ ID n° 8648 PL-594.1 3254293 to 83% ntrC - Salmonella typhimurium emb |CAA59425.1 |

3255765 (X85104) nitrogen regulatory protein C

[Salmonella typhimurium] SEQ ID n~3416

Contig9 from gb.|AAC82S2.3_._l (AF0 7768) TnpA [Serratia SEQ ID n° 8649 PL-5937Ï 3255831 to m 483 marcescens]

3257240 SEQ ID n~3415 ref |NP_051667. l| conserved hypothetical protein [Deinococcus radiodurans] pir| |D75633 conserved Contig9 from hypothetical protein - Deinococcus radiodurans

SEQ ID n° 8650 PL-592.1 3257144 to

(strain RI)

3260350 gb|AAF12566.l|AE001826_35 (AΞ001826) conserved hypothetical protein [Deinococcus radiodurans] SEQ ID n~3414 sp | P37129 | HEMN_SALTY OXYGΞN-INDEPΞNDΞNT

COPROPORPHYRINOGEN III OXIDASE

Contig9 from

(COPROPORPHYRINOGENASE) (COPROGEN OXIDASE) SEQ ID n° 8651 PL-591.1 3261907 to 86% gb|AAAlS6S0. l| (U0677S) putative oxygen-

3263280 independent coproporphyrinogen III oxidase

[Salmonella typhimurium] SEQ ID n~3413

Contig9 from

SEQ ID n° 8652 PL-6269.1 3263283 to m No Hits found

3263447 #N/A sp|P37130|YIHI_SALTY HYPOTHETICAL 19.2 KD

Contig9 from

PROTEIN IN POLA-HEMN INTERGENIC REGION

SEQ ID n° 8653 PL-3688.1 3263474 to 66% gb|AAA19691.l| (U06779) putative protein

3263983

[Salmonella typhimurium] SEQ ID n~2874

ContigS from pir] |B70367 hypothetical protein aq_765 -

SEQ ID n° 8654 PL-589.1 3264177 to 243 Aquifex aeolicus gb| AAC06926.l| (AE000706)

3265640 putative protein [Aquifex aeolicus] SEQ ID n~3410

Contig9 from

SEQ ID n° 8655 PL-6268.1 3265685 to m No Hits found

3265795 #N/A

Contig9 from gb|AAC31980.l| (L39897) HecB [Pectobacterium

SEQ ID n° 8656 PL-588.1 3266032 to 603 chrysanthemi]

3267711 SEQ ID n~3409

pir] |G81044 hemagglutinin/hemolysin-related protein NMB1779 [imported] -

Contig9 from

Neisseria meningitidis (group B strain MD58) -SEQ-ID n° 8657 PL-587.1 3267687""^"tθ^"— -403 gb|AAF42119.l| (AΞ002527)

3272900 hemagglutinin/hemolysin-related protein

[Neisseria meningitidis MC58] SΞQ ID n~3408

Contig9 from SEQ ID n° 8658 PL-3687.1 3272906 to No Hits found

3273451 SΞQ ID n~2873 Contig9 from SEQ ID n° 8659 PL-6266.1 3273582~tδ No Hits found

3273866 #N/A Contig9 from SEQ ID n° 8660 PL-3686.1 3273990 to No Hits found

3274358 SΞQ ID n~2872 pir||G83371 probable amino acid permease PA2202

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 8661 PL-585.1 3274785 to 71% (Strain PAOl) gb| AAG05590.l| AE004646_11

3275528 (AE004646) probable amino acid permease

[Pseudomonas aeruginosa] SΞQ ID n~3406 pir[ |H83371 probable amino acid permease PA2203

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 8662 PL-584.1 3275530 to 69% (strain PAOl) gb| AAG05591. l| AΞ004646_12

3276267 (AΞ004646) probable amino acid permease

[Pseudomonas aeruginosa] SEQ ID n~3405 pir| |C83369 probable binding protein component of ABC transporter PA2204 [imported]

Contig9 from

Pseudomonas aeruginosa (strain PAOl) SEQ ID n° 8663 PL-583.1 3276349 to 703 gb|AAG05592.l|AΞ004647_l (AΞ004647) probable

3277185 binding protein component of ABC transporter

[Pseudomonas aeruginosa] SEQ ID n~3404

sp|P07656|PHOU_ΞCOLI PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU pir| |BVECPU peripheral membrane protein U - Escherichia coli emb|CAA26510. l|

Contig9 from (X02723) phoU gène product (aa 1-241)

SEQ ID n° 8664 PL-582.1 3277354 to 88% [Ξscherichia coli] gb| AAA24382. l| (K01992)

3278085 peripheral membrane protein U [Ξscherichia coli] gb|AAC76747.l| (AΞ000449) négative regulator for pho regulon and putative enzyme in phosphate metabolism [Ξscherichia coli K12] SEQ ID n~3403 sp|P07655|PSTB_ECOLI PHOSPHATE TRANSPORT ATP- BINDING PROTEIN PSTB pir| ] BVECZB^" ABC-type phosphate transport system ATP-binding protein pstB [validated] - Ξscherichia coli emb|CAA26509.l| (X02723) pstB gène product (aa 1- 257) [Escherichia coli] gb |AAA24381. l| (K01992) peripheral membrane protein B [Bscherichia coli]

Contig9 from gb|AAA62076.l| (L10328) peripheral membrane

SEQ ID n° 8665 PL-581.1 3278088 to 92% protein B [Escherichia coli] gb| AC76748.1 |

3278864 (AE000449) ATP-binding component of high- affinity phosphate-specific transport system [Escherichia coli K12] gb|AAG58921.l|AΞ005603_7 (AE005603) ATP-binding component of high-affinity phosphate- specific transport system [Escherichia coli 0157 :H7] SEQ ID n~S402

Contig9 from dbj [BAA22863.l| (D89963) intégral membrane

SΞQ ID n° 8666 PL-580.1 3278891 to m 89% protein A [Enterobacter cloacae]

3279775 SEQ ID n~S401

Contig9 from dbj |BAA22862.l| (D89963) peripheral membrane

SEQ ID n° 8667 PL-579.1 3279777 to 89% protein C [Enterobacter cloacae]

3280748 SEQ ID n~S399

sp | PO6128 | PSTS_ECOLI PHOSPHATΞ-BINDING

PERIPLASMIC PROTEIN PRECURSOR (PBP) pir| | BYECPR phosphate-repressible phosphate-binding protein precursor [validated] - Escherichia

Contιg9 from coli gb|AAA24378.l| (K01992) phosphate-binding

SEQ ID n° 8668 PL-577.1 3280865 to 85% prote [Escherichia coli] gb|AAC76751.l| 3- 8-1-905- -

(AE000449) ^""High-affinity phosphate-specific transport system periplasmic phosphate-binding protein [Ξscherichia coli

K12] SEQ ID n~3398 sp|P08982 |ENVZ_SALTY OSMOLARITY SENSOR PROTEIN

Contig9 from ENVZ pir||S01357 inner membrane protein envZ -

SEQ ID n° 8669 PL-576.1 3282244 to m 76% Salmonella typhimurium emb| CAA30935.1 | (X12374)

3283575 envZ inner membrane protein (AA l - 450)

[Salmonella typhimurium] SΞQ ID n~3397 sp|P03025 |θMPR_ECOLI TRANSCRIPTIONAL REGULATORY

PROTΞIN OMPR pir| |RGΞCOR osmosensor response regulator ompR - Escherichia coli gb|AAA16241.l| (J01656) OmpR protein

[Escherichia coli] emb|CAA54510.l| (X77305) ompR [Salmonella typhi] gb| AAA58202.1 | (U18997)

CG Site No. 434; alternate name ompB

Contig9 from

[Escherichia coli] gb| AAC76430. l] (AE000416)

SEQ ID n° 8670 PL-575.1 3283572 to m 753 response regulator (sensor, EnvZ) affecting

3284291 transcription of ompC and ompF: outer membrane protein synthesis [Ξscherichia coli

K12] gb|AAG58506.l|AΞ005562_9 (AΞ005562) response regulator (sensor, EnvZ) affecting transcription of ompC and ompF : outer membrane protein synthesis [Escherichia coli

0157:H7] SEQ ID n~3 96

pir| |A65136 transcription elongation factor greb

- Escherichia coli (strain K-12)

Contig9 from gb|AAA58203.il (U18997) ORF_ol70 [Escherichia

-SEQ -I-D-n°-8671 PL-3684.1 3285145 to -p- -863 coli] gb|AAC7643l.l| (AE000416) transcription

3285618 elongation factor and transcript cleavage

[Escherichia coli K12] SEQ ID n~2871

Contig9 from sp P46837|YHGF_ECOLI 85.1 KDA PROTEIN IN GREB-

SEQ ID n° 8672 PL-574.1 3286041 to FEOA INTERGENIC REGION

3288371 SEQ ID n-3395

Sp|P33649|FEOA_ECOLI FERROUS IRON TRANSPORT

PROTEIN A pir| |B36932 iron(II) transport system protein feoA - Escherichia coli emb | CAA50386.1 |

(X71063) feoA [Escherichia coli] gb] AAA58206.l|

Contig9 from

(U18997) CG Site No. 28964 [Escherichia coli] SEQ ID n° 8673 PL-6263.1 3288769 to p 683 gb|AAC76433.l| (AΞ000416) ferrous iron transport

328S002 protein A [Escherichia coli K12] gb|AAG58509.l|AE005563_3 (AE005563) ferrous iron transport protein A [Escherichia coli

0157 :H7] #N/A

Contig9 from gb|AAG58510.l|AE005563_4 (AE005563) ferrous iron

SEQ ID n° 8674 PL-573.1 3283055 to p 85% transport protein B [Escherichia coli

3291367 0157 :H7] SEQ ID n~3394 sp|P46845|YHGG_EC0LI HYPOTHETICAL 8.7 KD PROTEIN

IN FEOB-BIOH INTERGENIC REGION (078) pir] |E65136 hypothetical 8.7 kD protein in feoB- bioH intergenic région - Escherichia

Contig9 from coli (strain K-12) gb| AAA58208. l| (U18997) SEQ ID n° 8675 PL-6262.1 3291377 to p 53%

ORF_o78 [Ξscherichia coli] gb|AAC76435.l|

3291616

(AE000416) orf, hypothetical protein

[Escherichia coli K12] gb]AAG58511.l|AE005563_5

(AΞ005563) orf, hypothetical protein

[Ξscherichia coli 0157 :H7] #N/A ref |NP_046944.l| gp48 [Bacteriophage N15]

Contig9 from pir| |T13135 protein gp 8 - phage N15

SEQ ID n° 8676 PL-3683.1 3291739 to m 29% gb|AAC19087.l| (AF064539) gp48 [Bacteriophage

3292041

N15] SEQ ID n~2870

ref |NP_046945.l[ gp49 [Bacteriophage N15]

Contig9 from pir| |T13136 protein gp49 - phage N15 SΞQ ID n° 8677 PL-6261.1 ^"3292034 to 483 gb|AAC19088.l| (AF064539) gp49 [Bacteriophage 3292366

N15] #N/A sp|P1300l|BIOH_ECOLI BIOH PROTBIN pir||BVΞCBH bioH protein - Escherichia coli emb] CAA33612.1 |

TX15587) bioH protein (AA 1-256) [Escherichia^"

Contig9 from coli] gb|AAA58210.l| (U18997) CG Site No. 954;

SEQ ID n° 8678 PL-572.1 3292443 to 74% alternate name bioB [Escherichia coli]

3293228 gb[AAC76437.l| (AE000417) biotin biosynthesis;

^"réaction prior to pimeloyl CoA

[Escherichia coli K12] SΞQ ID n~3393

Contig9 from SEQ ID n° 8679 PL-6260.1 3293228 to No Hits found

3293521 #N/A gb|AAC71703.l| (AF060183) putative

Contig9 from methyltransferase [Mycobacterium avium] SEQ ID n° 8680 PL-3681.1 3294028 to 243 gb|AAD20365.l| (AF125999) methyltransferase mtfC

3294471 [Mycobacterium avium] gb|AAD44210 ,l|AF143772_12

(AF143772) MtfC [Mycobacterium avium] SEQ ID n~2868 pir||S16426 tyrosine- -tRNA ligase (EC 6.1.1.1)

Contig9 from TyrZ - Bacillus subtilis emb|CAA51565.l| SEQ ID n° 8681 PL-571.1 3294482 to m 61% (X73124) ipa-9r [Bacillus subtilis]

3295681 emb|CAB15872.l| (Z99123) tyrosyl-tRNA synthetase

[Bacillus subtilis] SΞQ ID n~3392

Contig9 from gb|AAG58513.1JAE005563_7 (AE005563) biotin SEQ ID n° 8682 PL-6258.1 3295793 to m biosynthesis; reaction prior to pimeloyl CoA

3295990 [Escherichia coli 0157 :H7] #N/A pir| |H65136 hypothetical 27.7 kD protein in bioh gntt intergenic région - Escherichia

Contig9 from coli (strain K-12) gb|AAA58211.l| (U18997) SEQ ID n° 8683 PL-570.1 3296009 to 51%

0RF_o243 [Escherichia coli] gb| AAC76438.1 |

3296713

(AE000417) orf, hypothetical protein

[Escherichia coli K12] SEQ ID n~33Sl

sp|P46847|YHGI_ECOLI PROTEIN YHGI pir||A65137 hypothetical 21.0 kD protein in bioh-gntt intergenic région - Escherichia coli

Contig9-from-

(strain K-12) gb | AAA58212. l| (U18997) 0RF_ol91 SEQ ID n° 8684 PL-3680.1 3296773 to 933

[Escherichia coli] gb| AAC76439.1] (AE000417)

3297348 orf, hypothetical protein [Escherichia coli K12] gb|AAG58515. |AÈ00B563_9 (ÂË005563) orf, hypothetical protein [Escherichia coli 0157 :H7] SΞQ ID n~2867

Contig9 from gb|AAG58529.l|AΞ005565_4 (AE005565) protein of

SEQ ID n° 8685 PL-6255.1 3297479 to 533 glp regulon._[Ξs_cherichia coli 0157 :H7]

32_T78T4^~-" #N/A

Contig9 from gb]AAG58528.l]AE005565_3 (AE005565) protein of

SEQ ID n° 8686 PL-569.1 3297823 to 66% glp regulon [Escherichia coli 0157 :H7]

3298671 SEQ ID n~3389

Contig9 from gb|AAG58527.l|AE005565_2 (AE005565) repressor of

SEQ ID n° 8687 PL-568.1 3298689 to 87% the glp operon [Escherichia coli 0157 :H7]

3299447 SEQ ID n~3388

Contig9 from gb|AAG58530.l|AE005565_5 (AE005565) sn-glycerol-

SEQ ID n° 8688 PL-567.1 3299688 to 843 3 -phosphate dehydrogenase (aérobic)

3301190 [Escherichia coli 0157 :H7] SEQ ID n~3387

Contig9 from gb|AAG59083.l|AE005620_5 (AΞ005620) orf,

SEQ ID n° 8689 PL-6253.1 3301467 to m 483 hypothetical protein [Ξscherichia coli 0157 :H7]

3301697 #N/A pir|]C82284 hypothetical protein VC0764

Contig9 from

[imported] - Vibrio cholerae (group 01 SΞQ ID n° 8690 PL-566.1 3302031 to 453 strain N16961) gb | AAF93929.l| (AΞ004161)

3302930 hypothetical protein [Vibrio cholerae] SEQ ID n~3386

Contig9 from

SEQ ID n° 8691 PL-565.1 3303153 to No Hits found

3303707 SEQ ID n~3385

SΞQ ID n° 86Θ2 PL-6252.1

SEQ ID n° 8693 PL-3679.1

Contig9 from gb|AAD38235.l| (U17224) CarG [Pectobacterium

SEQ ID n° 8694 PL-3678.1 3304817 to 55% carotovorum]

3305353 SΞQ ID n~2864

Contig9 from gb|AAD38234.l] (U17224) CarF [Pectobacterium

SΞQ ID n° 8695 PL-3677.1 3305343 to 58% carotovorum]

3306191 SΞQ ID n~2863

Contig9 from gb|AAD38233.l| (U17224) CarE [Pectobacterium

SΞQ ID n° 8696 PL-6951.1 3306199 to 623 carotovorum]

3306453 #N/A

Contig9 from Sp|Q9XB58 |CARD_ERWCA CARBAPENEM ANTIBIOTICS

SΞQ^""ID n° 8697 PL-3101.1 3306440 to 62% BIOSYNTHBSIS PROTΞIN CARD gb | AAD38232.1 |

3307624 (U17224) CarD [Pectobacterium carotovorum] SΞQ ID n~2342

Contig9 from gb|AAD38231.l| (U17224) CarC [Pectobacterium

SEQ ID n° 8698 PL-3100.1 3307701 to m 893 carotovorum]

3308522 SΞQ ID n~2341

Contig9 from gb|AAD38230.l| (U17224) CarB [Pectobacterium

SEQ ID n° 8699 PL-3099.1 3308536 to 78% carotovorum]

3309285 SΞQ ID n~2338

Contig9 from gb|AAD38229.l| (U17224) CarA [Pectobacterium

SEQ ID n° 8700 PL-3098.1 3309288 to m 703 carotovorum]

3310793 SEQ ID n~2337

ContigS from

SEQ ID n° 8701 PL-6251.1 3311570 to m No Hits found

3311740 #N/A

Contig9 from gb|AAG58522.l|AΞ005564_7 (AE005564) orf;

SEQ ID n° 8702 PL-6250.1 3311929 to 73% hypothetical protein [Escherichia coli 0157 :H7]

3312201 #N/A

Contigθ from gb|AAG58523.l|AE005564_8 (AΞ005564) orf ;

SEQ ID n° 8703 PL-3676.1 3312192 to 663 hypothetical protein [Escherichia coli 0157:H7]

3312680 ΞΞQ ID n~2862

sp|P44480[ALKH_HAEIN PUTATIVΞ KHG/KDPG ALDOLASE

[INCLUDES : 4 -HYDROXY-2 -OXOGLUTARATE

ALDOLASΞ (2-KETO-4-HYDROXYGLUTARATE ALDOLASΞ)

(KHG-ALDOLASΞ) ; 2-DΞHYDRO-3-

DΞOXYPHOSPHOGLUCONATΞ ALDOLASE

(PHOSPHO- -DEHYDRO-3 -DΞOXYGLUCONATE ALDOLASE) reontig9—from

(PHOSPHO-2-KΞTO-3-DEOXYGLUCONATΞ ALDOL>

SΞQ ID n° 8704 PL-3097.1 3312763 to m 753 pir] |A64045 KHG-KDPG bifunctional aldolase 3313395

HI0047 [similarity] - Haemophilus influenzae (strain Rd KW20) gb |AAC21725.1 |

(U32690) -hydroxy-2 -oxoglutarate aldolase/2 -deydro-3 -deoxyphosphogluconate aldolase (eda) [Haemophilus influenzae Rd] SΞQ ID n~2336 sp | P44482 | DGK_HAEIN 2 -DEHYDRO-3 -

DEOXYGLUCONOKINASΞ (2 -KΞTO-3 -DΞOXYGLUCONOKINASΞ)

(3-DΞOXY-2-OXO-D-GLUCONATΞ KINASE) (KDG KINASE)

Contig9 from pir| |C64045 2-dehydro-3-deoxygluconokinase SΞQ ID n° 8705 PL-3096.1 3313410 to m 67% homolog - Haemophilus influenzae

3314354

(strain Rd KW20) gb|AAC21727.l| (U32690) 2- dehydro-3-deoxygluconokinase (kdgK) [Haemophilus influenzae Rd] SEQ ID n~2335 sp|P42607|UXAC_ECOLI URONATE ISOMERASE (GLUCURONATE ISOMΞRASΞ) (URONIC ISOMERASE)

Contig9 from pir| |A65098 glucuronate isomerase (EC 5.3.1.12) SEQ ID n° 8706 PL-3095.1 3314351 to 76% Escherichia coli dbj |BAA02587.1 | (D13328)

3315775 Uronate isomerase [Escherichia coli] gb|AAC76127.l| (AΞ000391) uronate isomerase

[Escherichia coli K12] SEQ ID n~2334

Contig9 from gb|AAG59505.l|AE005663_3 (AEO 05663) mannonate SEQ ID n° 8707 PL-3094.1 3315772 to 75% oxidoreductase [Escherichia coli 0157 :H7]

3317253 SEQ ID n~2333 Contig9 from sp | P40800 | YGIK_SALTY HYPOTHΞTICAL 46.1 KD SEQ ID n° 8708 PL-3093.1 3317281 to m 79% PROTEIN IN PLSC 3 'REGION gb | AAA56680.1 |

3318594 (U0930S) YgiK [Salmonella typhimurium] SEQ ID n~2332

Contig9 from gb|AAF01413.l|AF186091_l (AF186091) putative SEQ ID n° 8709 PL-3675.1 3318622 to m 51%- small intégral C4 -dicarboxylate membrane 3319128 transport protein DctQ [Klebsiella pneumoniae] SEQ ID n~ 86l

Contig9 from dbj |BAB04420.1[ (AP001509) C4-dicarboxylate SEQ ID n° 8710 PL-3092.1 3319426 to 543 transport system (C4-dicarboxylate-

3320406 binding protein) [Bacillus halodurans] SEQ ID n~2331 sp|P3916l|UXUR_ECOLI UXU OPERON TRANSCRIPTIONAL REGULATOR pir| |S56549 regulatory protein uxuR -

Contig9 from Escherichia coli gb|AAA97220.l| (U14003) CG SΞQ ID n» 8711 PL-3091.1 3320525 to 71% Site No. 12 [Escherichia coli] dbj |BAA02592.1 |

3321268 (D13329) uxu regulon repressor [Escherichia coli] gb|AAC77280.l| (AE000503) regulator for uxu operon [Escherichia coli K12] SEQ ID n~2330 sp|P44488 |UXUA_HAΞIN MANNONATΞ DΞHYDRATASE (D-

MANNONATΞ HYDROLASE) pir] |E64045 mannonate

Contig9 from dehydratase (EC 4.2.1.8) - Haemophilus SEQ ID n° 8712 PL-3090.1 3321306 to 833 influenzae - (strain Rd KW20)

3322493 gb| AC21733.l| (U32690) mannonate dehydratase

(uxuA) [Haemophilus influenzae Rd] SEQ ID n~2329

Contig9 from SΞQ ID n° 8713 PL-6247.1 3322835 to No Hits found

3323005 #N/A pir| |B82354 deoxycytidylate deaminase-related protein VC0175 [imported] - Vibrio

Contig9 from cholerae (group Ol strain N16961) SEQ ID n° 8714 PL-3089.1 3323260 to m 51% gb|AAF93351.l| (AE004108) deoxycytidylate

3324459 deaminase-related protein [Vibrio cholerae] SEQ ID n~2327

Contig9 from emb|CAB08016.l| (Z94043) penicillin-binding SEQ ID n° 8715 PL-3088.1 3325119 to m 26% protein [Bacillus subtilis]

3326708 SEQ ID n-2326 Contig9 from emb|CAB08016 ,l| (Z94043) penicillin-binding SEQ ID n° 8716 PL-3087.1 3326801 to m 243 protein [Bacillus subtilis]

3328396 SEQ ID n~2325

Contig9 from emb|CAB08016. l| (Z94043) penicillin-binding SEQ ID n° 8717 PL-3086.2 3328705 to 29% protein [Bacillus subtilis]

3330294 #N/A Contig9 from emb | CAB08016 . l | ( Z94043 ) penicillin-binding SEQ ID n° 8718 PL-3085.1 3330732 to 31% protein [Bacillus subtilis]

3332324 SEQ ID n~2323 Contig9 from SEQ ID n° 8719 PL-3674.1 3332817 to m No Hits found

3333320 SEQ ID n~2860 Contig9 from emb]CAB080l6. l| (Z94043) penicillin-binding SEQ ID n° 8720 PL-3084.1 3333483 to 29% protein [Bacillus subtilis]

3335075 SEQ ID n~2322 pir] |H83306 hypothetical protein PA2712

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 8721 PL-3083.1 3335448 to m 64% (strain PAOl) gb|AAG06100.l|AE004699_5

3336329 (AE004699) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2321

Contig9 from dbj |BAB06652.l| (AP001517) BH2933-unknown

SEQ ID n° 8722 PL-3082.1 3336489 to m 2£ [Bacillus halodurans]

3337679 SEQ ID n~2320

Contig9 from gb|AAD56249.l|AF186235_l (AF186235) L-

SEQ ID n° 8723 PL-3080.1 3338464 to m 733 arginine: lysine amidinotransferase [Pseudomonas

3339564 syringae pv. phaseolicola] SEQ ID n~2318

Contig9 from gb| AAC46152. l| (U89925) crystalline inclusion

SΞQ ID n° 8724 PL-4066.2 3340328 to 86% protein [Photorhabdus luminescens]

3340630 #N/A

Contig9 from

SΞQ ID n° 8725 PL-3079.2 3341566 to m No Hits found

3342504 #N/A

Contig9 from pir] |A48494 3 -methyladenine DNA glycosylase

SΞQ ID n° 8726 PL-3078.3 3342649 to 32% Bacillus subtilis

3343548 #N/A

Contig9 from

SEQ ID n° 8727 PL-6242.1 3343937 to No Hits found

3344362 #N/A

Contig9 from emb|CAB65593.l| (AL136058) putative helicase SBQ ID n° 8728 PL-1944.1 3344359 to m 24% [Streptomyces coelicolor A3 (2)]

3346218 SEQ ID n~î075

Contig9 from SEQ ID n° 8729 PL-1943.1 3346757 to m No Hits found

3347338 SEQ ID n~î074 pir| |F81045 hemagglutinin/hemolysin-related protein NMB1768 [imported] -

Contig9 from

Neisseria meningitidis (group B strain MD58) SEQ ID n° 8730 PL-6241.1 3347319 to 443 gb|AAF42109.l| (AE002526)

3347492 hemagglutiniri/hemolysin-related protein

[Neisseria meningitidis MC58] #N/A

Contig9 from SEQ ID n° 8731 PL-6240.1 3347556 to No Hits found

3347789 #N/A Contig9 from SΞQ ID n° 8732 PL-6239.1 3347838 to No Hits found

3347978 #N/A Contig9 from SEQ ID n° 8733 PL-6238.1 3348071 to No Hits found

3348241 #N/A pir| |A83056 hypothetical protein PA4711

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 8734 PL-3673.1 3348230 to m 27% (Strain PAOl) gb|AAG08097.1 |AE004885_2

3348616 (AE004885) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2859

Contig9 from SΞQ ID n° 8735 PL-6237.1 3348613 to m No Hits found

3348795 #N/A Contig9 from gb|AAG1 159.l| (AY007371) beta-ketoadipyl CoA SΞQ ID n° 8736 PL-1941.1 3348810 to m 77% thiolase [Burkholderia pseudomallei]

3350021 SEQ ID n~î073

sp | Q45072 | TFTE_BURCE MALEYLACETATE REDUCTASE

Contig9 from pir| | 140177 maleylacetate reductase (EC SEQ ID n° 8737 PL- 1940.1 3350079 to 67% _ 1.3.1.32) [validated] - Pseudomonas

3351143 cepacia gb |AAC43333.1 | (U19883) maleylacetate reductase [Burkholderia cepacia] SΞQ ID n~î072 pir||C83618 probable CoA transferase, subunit B

PA0227 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 8738 PL-1939.1 3351140 to m 683 gb|AAG03616.l|AE004460_9 (AE004460) probable CoA

3351919 transferase, subunit B [Pseudomonas aeruginosa] SEQ ID n~î070 pir| |B83618 probable CoA transferase, subunit A

PA0226 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 8739 PL-1938.1 3351916 to m 803 gb|AAG03615.l|AE004460_8 (AE004460) probable CoA

3352779 transferase, subunit A [Pseudomonas aeruginosa] SEQ ID n~î069

Contιg9 from dbj |BAB04258.l| (AP001508) ADP-dépendent

SEQ ID n° 8740 PL-1937.1 3352801 to m 623 aldéhyde dehydrogenase [Bacillus

3354270 halodurans] SEQ ID n~ï068

Contig9 from

SEQ ID n° 8741 PL-1936.1 3354290 to m No Hits found

3355141 SEQ ID n~ï067

Contig9 from

SΞQ ID n° 8742 PL-3671.1 3355311 to m No Hits found

3355811 SΞQ ID n~2858

Contig9 from gb|AAC38247.l[ (AF003947) PcaR [Rhodococcus

SEQ ID n° 8743 PL-1935.1 3355956 to 56% opacus]

3356726 SEQ ID n~î066

Contig9 from gb|AADl6952.l| (AF106566) RhuM [Salmonella

SΞQ ID n° 8744 PL-6229.1 3357088 to m 603 typhimurium]

3357240 #N/A

Contig9 from gb|AAD16952.l| (AF106566) RhuM [Salmonella

SEQ ID n° 8745 PL-1934.1 3357391 to m 573 typhimurium]

3358038 SEQ ID n~2065

gb|AAG55370.l|AE005277_ll (AE005277) unknown

Contig9 from

[Escherichia coli 0157.-H7] SEQ ID n° 8746 PL-1933.1 3358516 to 573 gb]AAG55778.l|AE005314 6 (AE005314) unknown 3359349

[Ξscherichia coli 0157 :H7] SEQ ID n-2064 sp|P77692|YKFI_ΞC0LI HYPOTHΞTICAL 12.9 KD

PROTEIN IN PROA-PBRR INTΞRGΞNIC REGION

Contig9 from pir| |E64749 hypothetical protein b0245 - SEQ ID n° 8747 PL-6226.1 3359463 to 84% Escherichia coli gb| AAB08664.1 | (U70214)

3359750 similar to E. coli ORF_ol09 [Escherichia coli] gb]AAC73348.l| (AΞ000132) orf, hypothetical protein [Escherichia coli K12] ~ ^""#N/A sp|P5214l]YFJZ_ECOLI HYPOTHETICAL 11.7 KDA

PROTΞIN IN ALPA-GABD INTBRGENIC RΞGION (O105) pir] |T08656 yfiz protein - Escherichia coli

Contig9 from gb|AAA79813.l| (U36840) ORF_ol05 [Escherichia SEQ ID n° 8748 PL-6224.1 3359825 to m 73% coli] gb|AAC75693.l] (AE000349) orf,

3360151 hypothetical protein [Ξscherichia coli K12] dbj |BAA16513.l| (D90889) similar to [SwissProt

Accession Number P52141] [Escherichia coli] #N/A sp|Q47685|YKFG_ECOLI HYPOTHETICAL 18.1 KD

PROTEIN IN PROA-PERR INTΞRGΞNIC REGION pir| |G64749 hypothetical protein b0247 -

Escherichia coli gb|AAB08667.l| (U70214)

Contig9 from similar to E. coli ORF_ol60, also similar to SEQ ID n° 8749 PL-3670.1 3360194 to 56% radC [Escherichia coli]

3360667 gb|AAC73350.l[ (AE000133) putative DNA repair protein [Escherichia coli K12] dbj |BAA779l6.l|

(D83536) Hypothetical 18.0 kd protein in alpA- gabD intergenic région (ol60) .

[Escherichia coli] SEQ ID n~2857

Contig9 from

SEQ ID n° 8750 PL-1932.1 3360805 to m No Hits found

3361554 SEQ ID n~S063

sp|P28912]YHHI_ECOLI H REPΞAT-ASSOCIATΞD PROTEIN

IN RHSB-PIT INTERGENIC REGION (ORF-H) pir| [S47703 H repeat-associated protein homolog

Contig9 from b3484 - Escherichia coli gb] AAC61885. l|

SEQ ID n° 8751 PL-1931.1 3361587 to 603 (L02370) H repeat-associated protein

3362717 [Escherichia coli] gb| AAB18459.1 | (U00039) alternate gène name^""^yhhl^" [Escherichia coli] gb|AAC76509.l| (AE000424) putative receptor

[Escherichia coli K12] SEQ ID n~î062

Contig9 from

SEQ ID n° 8752 PL-366S.1 3362997 to^" No Hits found

3363593 SEQ ID n~2855

Contig9 from

SEQ ID n° 8753 PL-6222.1 3363845 to No Hits found

3363979 #N/A pir||C82470 conserved hypothetical protein

VCA0347 VCAO506_._[imported] - Vibrio

Contig9 from cholerae (group Ol strain N16961) SEQ ID n° 8754 PL-621S.1 3364127 to 67% gb|AAF96255.l| (AE004372) conserved hypothetical

33643S3 protein [Vibrio cholerae] gb|AAF96409.l|

(AΞ004381) conserved hypothetical protein

[Vibrio cholerae] m/A

Contig9 from gb|AAG00942.l|AF272977_2 (AF272377) transposase SEQ ID n° 8755 PL-1930.1 3364576 to m 29% [Mycoplasma hyopneumoniae]

3366192 SEQ ID n-î.061 Contig9 from SEQ ID n° 8756 PL-1929.1 3366381 to No Hits found

3369632 SEQ ID n~!060 Contig9 from gb]AAD54663.l|AF097520_l (AF097520) Sai SEQ ID n° 8757 PL-1928.1 336S695 to m 863 integrase [Shigella flexneri]

3370909 SEQ ID n~î.05S

sp|P27298|0PDA_ΞC0LI OLIGOPEPTIDASE A pir||S47718 oligopeptidase A (EC 3.4.24.-) -

ContigS from

Escherichia coli gb| AAB18474. l| (U00039_)__CG_ SEQ ID ή^{0 ~}875O^~

. 1 3371402 to 81%

Site No. 18031 [Escherichia coli]

3373444 gb|AAC76523. l| (AE000426) oligopeptidase A

[Escherichia coli K12] SEQ ID n~2058 pir]|S477l7 hypothetical protein f285 -

Contig9 from Ξscherichia coli gb|AAB18473.l] (U00039) gtg SEQ ID n° 8759 PL-1926.1 3373451 to 843 start, alternate starts possible [Escherichia

3374194 coli] SEQ ID n~2057 sp|P14657|DHE4_UNKP NADP-SPECIFIC GLUTAMATE

DEHYDROGΞNASΞ (NADP-GDH) pir] |S06938 glutamate

Contig9 from dehydrogenase (NADP+) (ΞC 1.4.1.4) - SEQ ID n° 8760 PL-1925.1 3374232 to 91% unidentified bacterium

3375575 emb |CAA3443 . l| (X16399) glutamate dehydrogenase

(AA 1-446) [unidentified bacterium] SEQ ID n~î056 pir] [S47715 universal stress protein A -

Ξscherichia coli gb| AB18471.l| (U00039) uspA

[Ξscherichia coli] gb|AAC76520.1 | (AE000425)

Contig9 from universal stress protein; broad regulatory SEQ ID n° 8761 PL-3668.1 3375837 to m 733 function? [Escherichia coli K12]

3376268 gb|AAG58627.l|AE005574_4 (AΞ005574) universal stress protein; broad regulatory function?

[Escherichia coli 0157.-H7] SEQ ID n~2854

Contig9 from SEQ ID n° 8762 PL-6216.1 3376386 to m No Hits found

sp|P37632|uSPB_ECOLI UNIVERSAL STRESS PROTEIN B pir||S477l4 hypothetical 13K protein (pit-uspA intergenic région) - Escherichia coli

Contig9 from gb|AAB18470.l| (U00039) No définition line found SEQ ID n° 8763 PL-3667.1 3376733 to 56%

[Escherichia coli] gb| AAC76519. l| (AE000425)

3377068 orf, hypothetical protein [Escherichia coli K12] gb]AAG58626.l|AΞ005574_3 (AE005574) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n-2853

sp|P37308|PITA_ECOLI LOW-AFFINITY INORGANIC

PHOSPHATΞ TRANSPORTΞR 1 pir| |S47713 pitA protein - Ξscherichia coli gb| AAB18469.1 [

Contig9 from (U00039) CG Site^{^}No. 385 [Escherichia coli] SΞQ ID n° 8764 PL-1924.1 3377123 to 823 gb] AAC76518.1] (AΞ000425) low-affinity phosphate

3378613 transport [Escherichia coli K12] gb | AAG58625.1 |^"AE005574_2 (AE005574) low-affinity phosphate transport [Ξscherichia coli

0157 :H7] SBQ ID n~£055

Contig9 from gb|AAG58624.l[AB005574_l (AΞ005574) orf, SΞQ ID n° 8765 PL-1923.1 ^{~ "}3378883 to 803 hypothetical protein [Ξscherichia coli 0157 :H7]

3380067 SΞQ ID n~£054 pir| |F83493 probable MFS transporter PA1212

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 8766 PL-1922.1 3380348 to m 66% (strain PAOl) gb | AAG04601.1 ] AΞ004551_5

3381559 (AΞ004551) probable MFS transporter [Pseudomonas aeruginosa] SΞQ ID n~î053

Contig9 from emb|CABS2560. l| (AL356812) putative carboxylase, SEQ ID n° 8767 PL-1921.1 3381584 to m 39% [Streptomyces coelicolor A3 (2)]

3382777 SΞQ ID n~£052 Contig9 from SEQ ID n° 8768 PL-6211.1 3383725 to m No Hits found

3383823 #N/A Contig9 from SΞQ ID n° 8769 PL-3666.1 3384630 to m No Hits found

3385103 SΞQ ID n~2852 Contig9 from SΞQ ID n° 8770 PL-3665.1 3385103 to No Hits found

3385600 SΞQ ID n~2851 Contig9 from pir||S76456 hypothetical protein - Synechocystis SEQ ID n° 8771 PL-1920.1 3386354 to 233 sp. (strain PCC 6803) dbj |BAA18585.1 | (DS0915)

3387229 hypothetical protein [Synechocystis sp.] SΞQ ID n~î051 pir||C83390 cyanate lyase PA2052 [imported] -

Contig9 from Pseudomonas aeruginosa (strain PAOl) SEQ ID n° 8772 PL-3664.1 3387385 to m 80% gb|AAG05440.l|AE004631_9 (AE004631) cyanate

3387855 lyase [Pseudomonas aeruginosa] SΞQ ID n~2850

sp|P17582|CYNT_ΞCOLI CARBONIC ANHYDRASB pir| |QRΞCTC carbonate dehydratase (ΞC 4.2.1.1) -

Ξscherichia coli gb|AABl8063 ,ι| (U73857)

ContigS from — cyanate anhydrase [Bscherichia coli] SEQ ID n° 8773 PL-1S19.1 3387883 to m 733 gb|AAC73442. l| (AE000141) carbonic anhydrase

3388542

[Escherichia coli K12] gb| AG54688. l|AΞ005213_4

(AE005213) carbonic anhydrase [Escherichia coli

0157 :H7] SΞQ ID n-2.049 pir| |C83388 transcription regulator CynR PA2054

Contιg9 from [imported] - Pseudomonas aeruginosa SE ID n° 8774 PL-1918.1 3388887 to p 723 (strain PAOl) gb | AAG05442T1 |AE004632_1

3389789 (AΞ004632) transcriptional regulator CynR

[Pseudomonas aeruginosa] SΞQ ID n~3L048 pir| |E82521 hypothetical protein XF2735

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 8775 PL-1917.1 3389831 to m 44% (strain 9a5c) gb| AAF85520.1 | Ξ004080_2

3391006 (AΞ004080) hypothetical protein [Xylella fastidiosa] SΞQ ID n~2047 pir| |D82521 hypothetical protein XF2734

Contig9 from

[imported] - Xylella fastidiosa (strain SΞQ ID n° 8776 PL-1916.1 3391024 to m 44%

9a5c) gb|AAF85519.l|AE004080_l (AE004080)

3394425 hypothetical protein [Xylella fastidiosa] SEQ ID n~î046

^* Contig9 from SΞQ ID n° 8777 PL-1915.1 3394433 to m No Hits found

3395326 SEQ ID n~î045 pir| |F82523 hypothetical protein XF2733

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 8778 PL-1914.1 3395378 to m 423 (strain 9a5c) gb] AF85518.1 |AE004079_9

3396838 (AΞ004079) hypothetical protein [Xylella fastidiosa] SEQ ID n~î044

Contig9 from gb|AAA25124.l| (M16187) pullulanase precursor SEQ ID n° 8779 PL-1913.1 3397193 to m 77%

[Klebsiella aerogenes]

3400465 SEQ ID n~1043 Contig9 from emb|CAA74718.l| (Y14336) putative extracellular SEQ ID n° 8780 PL-3663.1 3401169 to m 46% protem containing predicted 35aa

3401663 signal peptide [Streptomyces reticuli] SEQ ID n~2849

Contig9 from gb|AAD12185.l| (U57900) utilizing regulatory SEQ ID n° 8781 PL-1912.1 3401771 to m 593 protein tutB [Thauera aromatica]

3402397 SEQ ID n~2042

^~sp \ P23222 | FIXL_BRAJA SENSOR PROTEIN FIXL pir||S13330 fixL protein - Bradyrhizobium

Contig9 from japonicum emb|CAA40143. l| (X56808) ttg start

SEQ ID n° 8782 PL_^19X1 3402397 to m 27% codon^" [Bradyrhizobium japonicum]

3403761 emb|CAA06276.l| (AJ005001) FixL protein

[Bradyrhizobium japonicum] SEQ ID n~î041 sp|P45852|YHHW_ECOLI PROTEIN YHHW pir||B65140

- ^~ -hypothetical 26.3 kD protein in gntR-ggt

Contig9 from intergenic région - Escherichia coli SΞQ ID n° 8783 PL-1910.1 3404452 to 86%

(Strain K-12) gb|AAA58237.l| (U18997) ORF_f231

3405147

[Escherichia coli] gb| AC76464.l| (AΞ000420) orf, hypothetical protein [Ξscherichia coli K12] SΞQ ID n~î040

Contig9 from SΞQ ID n° 8784 PL-1909.1 3405195 to 903 pdb | 1AYL | Phosphoenolpyruvate Carboxykinase

3406814 SΞQ ID n~î038 pir] (D65135 hypothetical 32.8 kD protein in rcA pckA intergenic région - Ξscherichia coli (strain K-12) gb|AAA58198.l| (U18997)

Contigθ from

0RF_o294 [Fscherichia coli] gb] AAC76426.1 |

SEQ ID n° 8785 PL-1908.1 3407054 to m 79%

(AΞ000415) orf, hypothetical protein

3407926

[Escherichia coli K12] gb|AAG585Ol.l|AE0O5562_4

(AΞ005562) orf, hypothetical protein

[Ξscherichia coli 0157 :H7] SEQ ID n~î037

Contig9 from gb|AAK03630.l| (AE006191) unknown [Pasteurella SEQ ID n° 8786 PL-6201.1 3407949 to m 74% multocida]

3408365 #N/A Contig9 from SEQ ID n° 8787 PL-1907.1 3408433 to m 68% gb|AAC28926.l| (U66822) UmoB [Proteus mirabilis]

3410565 SEQ ID n~î036 Contig9 from gb|AAG58497.l|AE005561_10 (AE005561) orf, SEQ ID n° 8788 PL-1906.1 3411042 to p 73% hypothetical protein [Escherichia coli 0157 :H7]

3411590 SEQ ID n~î035

Contig9 from gb|AAG584S6.1JAE005561_9 (AE005561) SΞQ ID n° 8789 PL-1905.1 3411634 to m 853 peptidoglycan synthetase; penicillin-binding 3414162 protein 1A [Escherichia coli 0157:H7] SΞQ ID n~î034

Contig9 from sp|P45753 |YRFD_ECOLI HYPOTHETICAL 29.0 KDA SEQ ID n° 8790 PL-1904.1 3414282 to p 403 PROTEIN IN HOFQ-MRCA INTERGENIC REGION

3415112 SΞQ ID n~î033 pir G82053 probable fimbrial assembly protein

PiIN VC2633 [imported] - Vibrio

Contig9 from cholerae (group 01 strain N16961) SEQ ID n° 8791 PL-3661.1 3415112 to 463 gb|AAF95774.l| (AΞ004329) fimbrial assembly

3415666 protein PïlN,^" putative [Vibrio cholerae] SΞQ ID n~2848

Contig9 from SEQ ID n° 8792 PL-3660.1 3415653 to No Hits found

3416198 SΞQ ID n~2847 sp|P3 749|HOFQ__ECOLI PROTEIN TRANSPORT PROTEIN

HOFQ PRΞCURSOR pir| |B65134 protein transport

Contig9 from protein hofq precursor - Bscherichia coli SEQ ID n° 8793 PL-1903.1 3416131 to 533 (strain K-12) gb] AAA58188.l| (U18997) hopQ

3417225 [Escherichia coli] gb|AAC76416.l| (AE000414) putative transport portein [Ξscherichia coli

K12] SΞQ ID n~2032

ContigS from gb|AAG58490.l|AE005561_3 (AE005561) shikimate SEQ ID n° 8794 PL-3659.1 3417595 to 943 kinase I [Escherichia coli 0157 :H7]

3418116 SΞQ ID n~2845 sp | O7639 | AROB_ΞCOLI 3 -DΞHYDROQUINATΞ SYNTHASΞ pir||SYECQ 3-dehydroquinate synthase (EC

4.6.1.3) - Escherichia coli emb|CAA27495.l|

(X03867) 3-dehydroquinate synthase (aa 1-362)

ContigS from [Escherichia coli] emb | CAA79666.1 [ (Z19601) SEQ ID n° 8795 PL-1902.1 3418164 to 85% ORF, aroB. Millar G., Coggins J.R. ; FEBS Lett.

3419264 200:11-17(1986) [Ξscherichia coli] gb|AAA58186.l| (U18997) 3 -dehydroquinate synthase [Ξscherichia coli] gb| AAC76414.1 j

(AΞ000414) 3 -dehydroquinate synthase

[Ξscherichia coli K12] SEQ ID n~2031

Contig9 from gb|AAG58488.l|AE005561_l (AΞ005561) putative SΞQ ID n° 8796 PL-1901.1 3419557 to 55% membrane protein; interfères with cell division

3420483 [Escherichia coli 0157 :H7] SΞQ ID n~2030 sp|P45454|DMA_SERMA DNA ADΞNINE METHYLASE

(DEOXYADENOSYL-METHYLTRANSFΞRASΞ) (M. SMADAM)

Contig9 from pir||S47099 site-specific DNA-methyltransferase SΞQ ID h^0" 8797 PL-1900.1 3420568 to 363 (adenine-specific) (ΞC 2.1.1.72) dam

3421380 Serratia marcescens emb|CAA55177.l| (X78412)

Deoxyadenosyl-methyltransferase [Serratia marcescens] SEQ ID n~5c.029 sp|P3266l|RPE_ECOLI RIBULOSE-PHOΞPHATΞ 3-

EPIMERASE (PENTOSΞ-5 -PHOSPHATE 3 -EPIMERASE)

(PPE) (R5P3E) pir| |E65133 ribulose-phosphate 3- epimerase (EC 5.1.3.1) - Escherichia coli

Contig9 from gb|AAA58183.l| (U18997) 24 kD protein

SEQ ID n° 8798 PL-1899.1 3421441 to 833

[Escherichia coli] gb] AAC76411.1] (AΞ000414) D-

3422121 ribulose-5 -phosphate 3 -epimerase [Escherichia coli K12] gb|AAG58486.l|AE005560_12

(AΞ005560) D-ribulose-5-phosphate 3-epimerase

[Escherichia coli 0157 :H7] SEQ ID n-î.026 sp|P32662|GPH_ΞCOLI PHOSPHOGLYCOLATΞ PHOSPHATASΞ

(PGP) pir| |S55288 phosphoglycolate phosphatase

(ΞC 3.1.3.18) [validated] -

Contig9 from Escherichia coli emb|CAA79664.l| (Z19601) ORF SEQ ID n° 8799 PL-1898.1 3422111 to 593 for 27kD protein. [Ξscherichia coli]

3422815 gb|AAA58182.l| (U18997) 27 kD protein in

ECDAMOPRA [Escherichia coli] gb|AAC764lo .l|

(AE000414) phosphoglycolate phosphatase

[Escherichia coli K12] SEQ ID n~î025

Contig9 from gb|AAG42458.l|AF308467_4 (AF308467) tryptophanyl

SEQ ID n° 8800 PL-1897.1 3422820 to 843 tRNA synthetase [Klebsiella aerogenes]

3423857 SEQ ID n~î024

Contig9 from

SEQ ID n° 8801 PL-6198.1 3424123 to m No Hits found

3424344 #N/A

Contig9 from SΞQ ID n° 8802 PL-6197.1 3424560 to No Hits found 3424853 #N/A

Contig9 from gb]AAK02295.l| (AE006055) unknown [Pasteurella SΞQ ID n° 8803 PL-1896.1 3424881 to 503 multocida]

3425804 SEQ ID n~i023 Contιg9 from SEQ ID n° 8804 PL-1895.1 3425773 to No Hits found

3426522 SEQ ID n~£022 sp|P4427θ|YG02_HAΞIN HYPOTHΞTICAL PROTΞIN HI1602 pir| [A64038 hypothetical protein HI1602 -

Contig9 from

Haemophilus influenzae (strain Rd SEQ ID n° 8805 PL-3658.1 3426524 to 283

KW20) gb|AAC23261.l] (U32834) H. influenzae

3427003 predicted coding région HI1602 [Haemophilus influenzae Rd] SΞQ ID n~2844

Contig9 from SEQ ID n° 8806 PL-6196.1 3427014 to No Hits found

3427187 #N/A sp|P45215|YΞ59_HAΞIN PROBABLE RNA POLYMBRASΞ

SIGMA FACTOR HI1459 pir| ]G64124 transcription

Contιg9 from initiation factor sigma homolog HI1459 - SEQ ID n° 8807 PL-1894.1 3427207 to 54%

Haemophilus influenzae (strain Rd

3427797

KW20) gb|AAC23107.l] (U32824) sigma factor, putative [Haemophilus influenzae Rd] SEQ ID n~î021

Contιg9 from gb|AAG59104.l|AE005622_6 (AE005622) orf, SEQ ID n° 8808 PL-1893.1 3428182 to 773 hypothetical protein [Ξscherichia coli 0157 :H7]

3428853 SΞQ ID n~ï020 Contιg9 from sp|P53655[SODM_YΞRΞN SUPΞROXIDΞ DISMUTASΞ [MN] SEQ ID n° 8809 PL-1892.1 3428972 to 81% emb|CAA65596.l| (X96852) sodA [Yersinia

3429598 enterocolitica] SΞQ ID n~î019

sp|P27550|ACSA_ECOLI ACΞTYL-COΞNZYMΞ A

SYNTHETASE (ACETATE--COA LIGASE) (ACYL-

ACTIVATING ENZYME) pir] D65215

Contig9 from acétate- -CoA ligase (EC 6.2.1.1) - Ξscherichia SEQ ID n° 8810 PL-1891.1 3429972 to 90% coli gb|AAC43163.l| (U00006) acetyl-CoA

3431927 sythetase [Ξscherichia coli] gb|AAC77039. l|

(AE000480) acetyl-CoA synthetase [Escherichia coli K12] SEQ ID n~2018

Contig9 from gb|AAG59266.l|AE005639_10 (AE005639) orf, SEQ ID n° 8811 PL-1890.2 3431992 to 753 hypothetical protein [Ξscherichia coli 0157 :H7]

3432303 #N/A pir| |F83241 probable sodium: soluté symporter

PA3234 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 8812 PL-6906.1 3432300 to 863 gb|AAG06622.l|AE004746_6 (AΞ004746) probable

3433949 sodium: soluté symporter [Pseudomonas aeruginosa] #N/A

Contig9 from SEQ ID n° 8813 PL-3657.1 3434198 to No Hits found

3434737 #N/A Contig9 from gb] AAA96312.l| (U50906) outer membrane adhérence SEQ ID n° 8814 PL-1888.1 3434737 to 563 protein-associated protein

3435810 [Escherichia coli] SEQ ID n-2.014 Contig9 from gb|AAF65225.l|AF249895__l (AF249895) putative SEQ ID n° 8815 PL-3656.1 3436141 to 623 transposase [Xanthomonas pv. mangiferaeindicae]

3436653 SEQ ID n~2843 Contig9 from gb|AAF61102.l|AF225215_l (AF225215) putative SEQ ID n° 8816 PL-3655.1 3436569 to 56% transposase [Xanthomonas oryzae pv. oryzae]

3437084 SEQ ID n~2842

ref |NP_047570.l| unknown [Yersinia pestis] pir| |T42852 hypothetical protein Y0012 -

Yersinia pestis plasmid pCDl gb] AAC69767. l|

(AF074612) unknown [Yersinia pestis]

Contig9 from emb|CAB54945.l| (AL117189) YPCD1.68C, Y0012, SEQ ID n° 8817 PL-6191.1 3437364 to 69% hypothetical protein, len: 68 aa; ^: 3437618 identical to corresponding CDS from Y. pestis

KIM5 pCDl (EMBL:AF074612) (68 aa) , fasta scores, opt: 453 z-score: 678.5

E(): 2e-30 98.5% identity in 68 aa overlap. Similar to parts of hypothe> ^{" "} - #N/A gb|AAC31494.l| (AF071034) L0015 [Fscherichia

COli] gb|AAG54625.l|AE005206_13 (AE005206) unknown protein encoded in ISEc8 [Ξscherichia coli 0157 :H7] gb|AAG56018.l|AΞ005334_5 (AE005334) unknown protein encoded by ISEcδ in prophage CP-933X

[Escherichia coli 0157 :H7] gb|AAG56196.l|AE005348_13 (AE005348) putative IS

ContigS from encoded protein encoded within prophage SEQ ID n° 8818 PL-1887.1 3437603 to m 50%

CP-9330 [Escherichia coli 0157 :H7]

3438868 gb|AAG57057.l|AE005425_7 (AE005425) unknown protein encoded by ISΞc8 [Ξscherichia coli

0157:H7] gb | AG58121.1 | AE005528_11 (AE005528) unknown protein encoded by ISEcδ [Escherichia coli 0157 :H7] gb|AAG58813.l|AE005594_8 (AE005594) unknown protein encoded by ISEcδ within prophage CP-933L

[Escherichia coli 0157 :H7] SEQ ID n~2013 gb|AAG55308.1 | E005273_1 (AE005273) unknown in

Contig9 from

ISEc8 [Escherichia coli 0157 :H7] SEQ ID n° 8819 PL-6188.1 3438932 to m 73% gbjAAG55717.l|AE005309_7 (AE005309) unknown in

3439267

ISEc8 [Escherichia coli 0157 :H7] #N/A

Contig9 from SEQ ID n° 8820 PL-6187.1 3439261 to m No Hits found

3439563 #N/A

Contig9 from SEQ ID n° 8821 PL-7386.1 3442463 to No Hits found

3442597 #N/A

Contig9 from gb|AAG58958.l|AΞ005607_4 (AΞ005607) yieP gène SEQ ID n° 8822 PL-6164.1 3445247 to 633 product [Ξscherichia coli 0157 :H7]

3445468 #N/A

Contig9 from gb|AAG58958.l|AΞ005607_4 (AΞ005607) yieP gène SEQ ID n° 8823 PL-6163.1 3445449 to p 52% product [Escherichia coli 0157 :H7]

3445694 #N/A Contig9 from gb|AAG58957.l]AΞ005607_3 (AE005607) putative SEQ ID n° 8824 PL-805.1 3445764 to p 843 transport protein [Escherichia coli 0157 :H7]

3447155 SEQ ID n~3644 sp|P2555l|RBSR_ECOLI RIBOSΞ OPΞRON RΞPRESSOR pir| |B65179 ribose operon repressor -

Escherichia coli dbj |BAA01259.l| (D10466) rbs

Contig9 from repressor [Escherichia coli] gb| AAC76776. l| SΞQ ID n° 8825 PL-806.1 3447152 to m 79%

(AEO 00452) regulator for rbs operon [Escherichia

3448153 coli K12] gb|AAG58956.l|AE005607_2 (AE005607) regulator for rbs operon [Escherichia coli

0157 : H7] SEQ ID n~3645

sp | O5054 | RBSK_ECOLI RIBOKINASE pir | | IECRB ribokinase (EC 2.7.1.15) [validated] -

Escherichia coli pdb[lRK2(B Chain B, Ξ. Coli

Ribokinase Complexed With Ribose And Adp, Solved

In Space Group P212121 pdb|lRKD| E. Coli

Ribokinase Complexed With Ribose And Adp pdb|lRK2]C Chain c, E. Coli Ribokinase Complexed

With Ribose And Adp, Solved In Space

Group P212121 pdb|lRK2|A Chain A, E. Coli

Ribokinase Complexed With Ribose And Adp, Solved

Contig9 from

In Space Group P212121 pdb]lRK2|D Chain D, Ξ.

SEQ ID n° 8826 PL-807.1 3448156 to 79%

Coli Ribokinase Complexed with Ribose And Adp,

3449085

Solved In Space Group P212121 pdb|lRKA|A Chain A, The Apo Form Of E. Coli

Ribokinase pdb | 1RKS | A Chain A, E . Coli

Ribokinase in Complex with D-Ribose gb(AAA51476.l| (M13163) ribokinase [Escherichia coli] gb|AAA62105.l| (L10328) ribokinase

[Escherichia coli] gb] AAC76775.l] (AΞ000452) ribokinase [Escherichia coli K12] gb|AAG58355.l(AE005607_l (AE005607) ribokinase

[Escherichia coli 0157 :H7] SEQ ID n~S 46

Contig9 from gb|AAG58954.l|AE005606_10 (AE005606) D-ribose SEQ ID n° 8827 PL-808.1 3449149 to m 86% periplasmic binding protein [Escherichia coli

3450039 0157 :H7] SEQ ID n~3647 sp|P04984|RBSC_ECOLI RIBOSE TRANSPORT SYSTEM

PERMΞASE PROTΞIN RBSC pir | |G65178 high affinity ribose transport protein rbsC - Ξscherichia coli

ContigS from gb|AAA62103.l| (L10328) high affinity ribose SEQ ID n° 8828 PL-809.1 3450064 to m 89% transport protein [Escherichia coli]

3451035 gb|AAC76773.l| (AE000452) D-ribose high-affinity transport system [Escherichia coli

K12] SEQ ID n~3648

sp|P04983|RBSA_ΞCOLI RIBOSΞ TRANSPORT ATP- BINDING PROTEIN RBSA pir| |B26304 ribose transport protein rbsA - Escherichia coli eont-ig9 from gb|AAA51473.l| ^M13169) high affinity ribose

SEQ ID n° 8829 PL-810 .1 3451042 to m 86% transport protein [Escherichia coli] 3452547 gb|AAC76772.l| (AE000452) ATP-binding component of D-ribose high-affinity transport system [Ξscherichia coli K12] SEQ ID n~3650 gb|AAG58951.l|AE005606_7 (AE005606) D-ribose

Contig9 from high-affinity transport system; SEQ ID n° 8830 PL-6161..1 3452555 to m 783 membrahe-associated protein [Escherichia coli

3452974

0157 :H7] #N/A

Contig9 from gb|AAG58949.l|AE005606_5 (AE005606) putative 2-

SEQ ID n° 8831 PL-811.1 3453227 to 713 component regulator [Escherichia coli

3454738 0157 :H7] SEQ ID n~3651

Contig9 from gb]AAG58948.l|AE005606_4 (AΞ005606) yieM gène

SEQ ID n° 8832 PL-812.1 3454743 to P 763 product [Ξscherichia coli 0157 :H7]

3456200 SEQ ID n~3652

Contig9 from gb|AAG58947.l|AΞ005606_3 (AE005606) asparagine

SΞQ ID n° 8833 PL-813.1 3456207 to m 783 synthetase A [Escherichia coli 0157 :H7]

3457199 SEQ ID n~3653 sp|P03809|ASNC_ECOLI REGULATORY PROTEIN ASNC pir| |QQECΞ1 regulatory protein asnC -

Ξscherichia coli gb|AAA62095.l| (L10328) regulatory protein [Ξscherichia coli]

Contig9 from gb|AAA24252.l| (K00826) 17K protein [Ξscherichia SEQ ID n° 8834 PL-3652.1 3457366 to 853 coli] gb|AAC76766.l| (AE000451) regulator for

3457827 asnA, asnC and gidA [Ξscherichia coli K12] gb|AAG58946.l|AΞ005606_2 (AΞ005606) regulator for asnA, asnC and gidA [Ξscherichia coli

0157-.H7] prf | |1002215B protein 17KD

[Bscherichia coli] SEQ ID n~2841

sp | P03817 | IOC_ΞCOLI MIOC PROTEIN pir ] | QQEC16 mioC protein - Escherichia coli gb| AAA62094.1 | (L10328) involved in modulation of initiation at

Contig9 from oric [Escherichia coli] SEQ ID n^» 8835 PL-3651.1 3457919 to 733 gb |AAA2425l.l| (K00826) 16K protein [Escherichia

3458359 coli] gb|AAC76765.l| (AE000451) initiation of chromosome réplication^" [Escherichia coli K12] prf | |l002215A protein 16kD [Escherichia coli] SEQ ID n~2840 sp|P17112|GIDA_ΞCOLI GLUCOSΞ INHIBITΞD DIVISION

PROTEIN A pir| | BVECςÂTglucose inhibited

Contig9 from division protein - Escherichia coli

SEQ ID n° 8836 PL-814.2 3458740 to 90% gb|AAC76764. l| (AE000451) glucose-inhibited

3460629 division,- chromosome réplication?

[Escherichia coli K12] SEQ ID n~3654 sp|P17113]GIDB_ECOLI GLUCOSΞ INHIBITΞD DIVISION

PROTΞIN B pir | | BVBCQB gidB protein -

Escherichia coli gb| AAA6209 . l| (L10328) glucose inhibited division protein [Escherichia

Contig9 from coli] emb|CAA25774.l| (X01631) gidB protein

SEQ ID n° 8837 PL-815.1 3460643 to 813 [Ξscherichia coli] gb| AAC76763.l| (AE000451)

3461263 glucose-inhibited division; chromosome réplication? [Escherichia coli K12] gb|AAG58943.l|AE005605_ll (AΞ005605) glucose- inhibited division; chromosome réplication? [Escherichia coli θl57:H7] SEQ ID n~3655

pir] |BVECUI uncl protein - Escherichia coli gb|AAA24730.l| (J01594) ATP synthase Uncl polypeptide (atp-1; gtg start codon)

[Escherichia coli] ggbb||AAAAAA662200SSll..ll|| (L10328) ATP synthase subunit? [Escherichia coli] emb|CAA25640.l[ (X01383) atpj gène product (AA 1-

128) [Escherichia coli] emb| CAA23513.l|

(V00264) reading frame gène 1 (A) [Escherichia

Contig9 from coli] emb|CAA25775.l| (X01631) uncl protein SEQ ID n° 8838 PL-3650.1 3461874 to 523

[Ξscherichia coli] gb| AAC76762.1 | (AE000450)

3462251 membrane-bound ATP synthase, dispensable protein, affects expression of atpB

[Escherichia coli K12] gb |AAF13355.l| AF188265_1

(AF188265) ATP synthase subunit i [Salmonella typhimurium] gb | AAG58942.1 | Ξ005605_10

(AΞ005605) membrane-bound ATP synthase, dispensable protein, affects expression of atpB [Ξscherichia coli 0157 :H7] SEQ ID n~2839 sp|P00855|ATP6_ECOLI ATP SYNTHASE A CHAIN

(PROTEIN 6) pir| |LWEC6 H+-transporting ATP synthase (EC 3.6.1.34) protein 6 - Ξscherichia coli emb|CAA23514.l| (V00264) reading frame gène 2 (A) [Escherichia coli] emb| CAA25776.1 |

(X01631) uncB protein [Escherichia coli] gb|AAA24731.l| (J01594) ATP synthase a subunit

Contig9 from

(atp-2) [Escherichia coli] gb|AAA62090. l|

SΞQ ID n° 8839 PL-816.1 3462282 to 87%

(L10328) ATP synthase FO subunit a [Escherichia

3463106 coli] emb] CAA23520.l| (V00266) alternate atpB

CDS [Escherichia coli] gb| AAC76761.l|

(AE000450) membrane-bound ATP synthase, FO sector, subunit a [Escherichia coli

K12] gb|AAG58941.l|AΞ005605_9 (AΞ005605) membrane-bound ATP synthase, FO sector, subunit a [Escherichia coli θl57:H7] SEQ ID n~3656

sp|P00844|ATPL_ECOLI ATP SYNTHASE C CHAIN (LIPID-

BINDING PROTEIN)

(DICYCLOHEXYLCARBODIIMIDE-BINDING PROTEIN) pir| |LWECA H+-transporting ATP synthase (EC

3.6.1.34) lipid-binding protein

Escherichia coli pdb|lC17|A Chain A, Alcl2

Subcomplex Of Fifo Atp Synthase pdb | 1C17 | B

Chain B, Alcl2 Subcomplex Of Fifo Atp Synthase pdb|lC17|C Chain C, Alcl2 Subcomplex Of Fifo Atp

Synthase pdb|lC17|D Chain D, Alcl2 Subcomplex

Contig9 from Of Fifo Atp^"Syhthase pdb|lC17|E Chain Ξ, Alcl2 SEQ ID n° 8840 PL-6159.1 3463160 to 91% Subcomplex Of Fifo Atp Synthase pdb | 1C17 | F

3463399 Chain F, Alcl2 Subcomplex Of Fifo Atp Synthase pdb|lC17|G Chain G, Alcl2 Subcomplex Of Fifo Atp

Synthase pdb|lC17|H Chain H, Alcl2 Subcomplex

Of Fifo Atp Synthase pdb|lC17|l Chain I, Alcl2

Subcomplex Of Fifo Atp Synthase pdb | 1C17 ]

Chain J, Alcl2 Subcomplex Of Fifo Atp Synthase pdb|lC17|κ Chain K, Alcl2 Subcomplex Of Fifo Atp

Synthase pdb]lC17|L Chain L, Alcl2 Subcomplex

Of Fifo Atp Synthase pdb(lA9l| Subunit C Of

The Fifo Atp Synthase Of Ξscherichia Coli; Nmr,

10 Structures pdb|lC99|A Chain A, #N/A

sp|P00859|ATPFJΞCOLI ATP SYNTHASE B CHAIN pir| |LWECB H+-transporting ATP synthase (EC

3.6.1.34) chain b - Escherichia coli gb|AAA8387l.l| (M25464) intégral membrane proton channel FO subunit B [Ξscherichia coli] gb|AAA24733.l| (J01594) ATP synthase b subunit (atp-4; gtg start codônT^" [Ξscherichia coli] gb|AAA62088.l| (L10328) ATP

Contig9 from synthase FO subunit b [Escherichia coli]

SΞQ ID n° 8841 PL-3649.1 3463458 to 933 emb|CAA23516.l| (V00264) reading frame gène 4

3463928 (B) [Ξscherichia coli] emb| CAA23523.1 | (V00266) atpF [Ξscherichia coli] emb|CAA25778. l(

(X01631) uncF protein [Escherichia coli] gb|AAC76759.l| (AE000450) membrane-bound ATP synthase, FO sector, subunit b

[Escherichia coli K12] gb| AG58939. l|AE005605_7

(AEO05605) membrane-bound ATP synthase, FO sector, subunit b [Ξscherichia coli

0157 : H7] SΞQ ID n~2837

sp|P0083l|ATPD_ECOLI ATP SYNTHASE DELTA CHAIN pir| [PWECD H+-transporting ATP synthase (EC 3.6.1.34) delta chain - Ξscherichia coli emb|CAA23517.1 | (V00264) reading frame gène 5 (delta) [Escherichia coli] emb|CAA23524.l| (V00266) atpH [Escherichia coli] emb|CAA25779.l| (X01631) uncH protein [Escherichia coli] gb| AAA83872.l| (M25464) H+

Contig9 from ATPase FO delta subunit [Escherichia coli] SΞQ ID n° 8842 PL-3648.1 3463941 to 87% gb|AAA24734.l| (J01594) ATP synthase delta

3464474 subunit (atp-5) [Escherichia coli] gb|AAA62087.l| (L10328) ATP synthase FI delta subunit [Ξscherichia coli] gb|AAC76758.1 | (AE000450) membrane-bound ATP synthase, FI sector, delta-subunit [Escherichia coli K12] gb|AAG58938.l|AΞ005605_6 (AΞ005605) membrane-bound ATP synthase, FI sector, delta- subunit [Escherichia coli 0157.-H7] SΞQ ID n~2836 sp|P00822|ATPA_ECOLI ATP SYNTHASE ALPHA CHAIN pir| |PWECA H+-transporting ATP synthase (ΞC 3.6.1.34) alpha chain - Escherichia coli gb|AAA62086.l| (L10328) ATP synthase Fl

Contig9 from alpha subunit [Ξscherichia coli] gb|AAC76757.1 |

SEQ ID n° 8843 PL-817.1 3464489 to 92% (AΞ000450) membrane-bound ATP synthase, Fl

3466030 sector, alpha-subunit [Escherichia coli K12] gb(AAG58937.l|AE005605_5 (AE005605) membrane-bound ATP synthase, Fl sector, alpha- subunit [Ξscherichia coli 0157 :H7] SΞQ ID n~3657

Contig9 from gb|AAF19361.l|AF188265_7 (AF188265) ATP synthase

SEQ ID n° 8844 PL-818.1 3466089 to 933 subunit gamma [Salmonella typhimurium]

3466S52 SΞQ ID n~S658

sp|P00824|ATPB_ECOLI ATP SYNTHASE BETA CHAIN pir] |PWECB H+-transporting ATP synthase (ΞC

3.6.1.34) beta chain - Ξscherichia coli emb|CAA23527.l| (V00267) reading frame beta [Escherichia coli] emb|CAA23594.l|

(V00311) reading frame papB [Escherichia coli] gb|AAA83875.l| (M25464 )~H+^~ATPase Fl beta subunit [Escherichia coli] gb| AAA24737.1 |

Contig9 from

(J01594) ATP synthase beta subunit (atp-8)

SEQ ID n° 8845 PL-813.1 3466987 to 95%

[Escherichia coli] gb|AAA62084.l| (L10328) ATP

3468369 synthase Fl beta^"" subunit [Escherichia coli] emb[CAA25782.l| (X01631) uncD protein [Escherichia coli] gb|AAC76755.l| (AE000450) membrane-bound ATP synthase, Fl sector, beta- subunit [Escherichia coli K12] gb|AAG58935.l|AE005605_3 (AE005605) membrane- bound ATP synthase, Fl sector, beta-subunit [Ξscherichia coli θl57:H7] SEQ ID n~3659 pdb|lBSH|A Chain A, Solution Structure Of The Epsilon Subunit Of The Fl- Atpsynthase From Escherichia Coli And Orientation Of The Subunit Relative

Contig9 from To The Beta Subunits Of The Complex pdb|lBSN|A SEQ ID n° 8846 PL-6157.1 3468391 to 88%

Chain A, Solution Structure Of The Epsilon

3468813

Subunit Of The Fl- Atpsynthase From

Escherichia Coli And Orientation Of The

Subunit Relative To The Beta Subunits Of The

Complex / sp | P17114 | GLMU_ECOLI UDP-N-ACETYLGLUCOSAMINE

PYROPHOSPHORYLASE (N-

Contig9 from ACETYLGLUCOSAMINE-1- HOSPHATE URIDYLTRANSFERASE)

SΞQ ID n° 8847 PL-820.1 3468942 to 86% pir| |C65176 glmU protein - Escherichia coli

3470315 (strain K-12) gb| AAC76753. l| (AE000450) N- acetyl glucosamine-1-phosphate uridyltransferase

[Escherichia coli K12] SEQ ID n~S661

sp ] P17169 | GLMS_JECOLI GLUCOSAMINE- -FRUCTOSE- 6- PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] (HEXOSΞPHOSPHATΞ AMINOTRANSFERASE) __ _ (D- FRUCTOSΞ-6-PHOSPHATE AMIDOTRANSFERASE) (GFAT)

(L-GLUTAMINE-D-FRUCTOSF-6-PHOSPHATΞ

Contig9 from AMIDOTRANSFERASE) (GLUCOSAMINΞ-6- SEQ ID n-V-8-845—-PL-822.1 3470423 to p 85%

PHOSPHATE SYNTHASΞ) pir] |XNΞCGM glutamine- -

3472252 fructose-6-phosphate transaminase (isomerizing)

(EC 2.6.1.16) - Ξscherichia coli gb|AAC7675 . l| (AE000450) L-glutamine:D-fructose-

6-phosphate aminotransferase

[Escherichia coli K12] SEQ ID n~3662

Contig9 from gb|AAB18024.l] (U73857) hypothetical protein SEQ ID n° 8849 PL-6156.1 3472401 to 62% [Ξscherichia coli]

3472655 #N/A pir] |D82269 probable ribosomal protein L36

Contig9 from VC0879 [imported] - ibrio cholerae SEQ ID n° 8850 PL-6155.1 3472675 to 37% (group Ol strain N16961) gb | AAF94041.1 |

3472815 (AEO04172) ribosomal protein L36, putative

[ ibrio cholerae] #N/A

Contig9 from pir| |S18689 Sc/SvP protein - Escherichia coli SEQ ID n° 8851 PL-823.1 3473230 to 22% plasmid pl5B emb|CAA44052.l| (X62121) DNA

3474285 inversion product [Escherichia coli] SEQ ID n~9663 sp|Q47427|TFAB_ΞCOLI TAIL FIBER ASSEMBLY PROTEIN

Contig9 from HOMOLOG pir| |S18684 gène T protein - SEQ ID n° 8852 PL-824.1 3474333 to 573 Ξscherichia coli plasmid pl5B emb| CAA440 7.1 |

3474917

(X62121) T [Ξsσherichia coli] SΞQ ID n~3664

Contig9 from sp|P40784]YCDD_SALTY HYPOTHETICAL PROTEIN IN SEQ ID n° 8853 PL-6154.1 3475336 to 373 NANH 3 ' EGION

3475677 #N/A Contig9 from dbj |BAA76527.2| (AB017338) tail fiber SEQ ID n° 8854 PL-825.1 3475687 to m 20% [Pectobacterium carotovorum]

3476697 SEQ ID n~3665

sp|P03013|HIN_SALTY DNA-INVΞRTASE HIN pir| | JWEBT DNA-invertase - Salmonella sp emb|CAA24652.l| (V01369) reading frame (HIN)

Gθnfeig-9— f-rom

[Salmonella typhimurium] emb|CAA24654.1 | SEQ ID n° 8855 PL- 3647 . 1 3476777 to 833

(V01370) hin gène [Salmonella typhimurium]

3477349 gb|AAA27073.l| (J01801) hin protein [Salmonella typhimurium] jb] AAA27140.1 | (M12293) flagellar protein [Salmonella typhimurium] SΞQ ID n~2835 sp|P 1323 |YR7I_ECOLI HYPOTHETICAL 21.9 KD

Contig9 from PROTEIN (ORFl) (RΞTRON EC67) pir] | JQ0864 SΞQ ID n° 8856 PL-826.2 3477632 to m 523 hypothe^"tical 21.9K protein - Ξscherichia coli

3478246 retron Ec67 gb|AAA23390. l| (M55249) unknown

[Escherichia coli] SΞQ ID n~3666

Contig9 from SEQ ID n° 8857 PL-6152.1 3478628 to No Hits found

3478810 #N/A ref |NP_046763. l| gpX [Bacteriophage P2]

Contig9 from sp|P51772]VPX_BPP2 TAIL PROTBIN X (GPX) SEQ ID n° 8858 PL-6151.1 3479093 to 653 pir| |B55855 tail protein - phage P2

3479296 gb|AAD03274.l| (AF063097) gp [Bacteriophage P2] #N/A ref |NP_04677l.l | gpV [Bacteriophage P2]

Contig9 from sp|P3134θ|VPV_BPP2 BASBPLATE ASSΞMBLY PROTBIN V SEQ ID n° 8859 PL-827.1 3479793 to 433

(GPV) gb|AAD03282.l| (AF063097) gpV

3480635

[Bacteriophage P2] SEQ ID n~3667

Contig9 from ref |NP_052264.l( M protein [Enterobacteria phage SEQ ID n° 8860 PL-6150.1 3480635 to 523 186] gb|AAC34161.l| (U32222) M protein

3480976 [Ξnterobacteria phage 186] /A ref |NP_0 6773.1 | gpJ [Bacteriophage P2]

Contig9 from sp|P51767|VPJ_BPP2 BASEPLATE ASSEMBLY PROTEIN

SEQ ID n° 8861 PL-828.1 3480981 to p 683

(GPJ) gb|AAD03284.l| (AF063097) gpJ

3481979

[Bacteriophage P2] SEQ ID n~3668

Contig9 from ref |NP_046774.l| gpl [Bacteriophage P2]

SEQ ID n° 8862 PL-829.1 3481972 to 663 sp|P2670l|VPI_BPP2 TAIL PROTEIN I (GPI)

3482586 gb|AAD03285.l| (AF063097) gpl [Bacteriophage P2] SEQ ID n~3669

ref |NP_052267.l| similar to P2 tail fiber protein H, PIR Accession Number B42291

ContigS from

[Enterobacteria phage 186] gb]AAC34164.l] -SΞQ—ID-n° 8863 PL-830.1 3482583 to -p 43%-

(U32222) similar to P2 tail fiber protein H, PIR

3483710

Accession Number B42291

[Enterobacteria phage 186] SΞQ ID n~3671

ContigS from pir||si8687 Sc/SvN protein^" -^"Escherichia coli SΞQ ID n° 8864 PL-3645.1 3483710 to 543 plasmid pl5B emb|CAA44050.l| (X62121) DNA

34841S8 inversion product [Escherichia coli] SEQ ID n-2834 sp]P09153|TFAE_ECOLI TAIL FIBΞR ASSΞMBLY PROTΞIN

ContigS from HOMOLOG FROM LAMBDOID PROPHÂGΞ E14 pir| |A64861 SΞQ ID n° 8865 PL-831.1 34841S8 to 603 ycfA protein, phage protein-related -

3484794 Escherichia coli gb|AAC74240.1 | (AEO 00214) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~3672 ref |NP_046776.l| gpG [Bacteriophage P2]

Contig9 from sp[P26699|TFA_BPP2 PROBABLE TAIL FIBΞR ASSΞMBLY SΞQ ID n° 8866 PL-3644.1 3485024 to m 64% PROTEIN (GPG) pir||C42291 tail fiber assembly

3485554 protein G - phage P2 gb|AAD03287.1 | (AF063097) gpG [Bacteriophage P2] SEQ ID n~2833 pir] |A42463 hypothetical protein Bcv (pinB 5'

Contig9 from région) - Shigella boydii (fragment) SΞQ ID n° 8867 PL-832.1 3485570 to m 333 dbj |BAA00552.l| (D00660) Bcv gène product

3486121

[Shigella boydii] SEQ ID n~3673

Contig9 from

SEQ ID n^» 8868 PL-6148.1 3486118 to m No Hits found

3486324 #N/A

Contig9 from gb|AAD54236.l|AF153829_2 (AF153823) unknown

SΞQ ID n° 8869 PL-833.1 3486539 to 82% [Salmonella typhi]

3487711 SEQ ID n~3674

ref |NP_052270.1 | similar to P2 tail tube protein Fil, Swiss-Prot Accession Number

_P22502 [Enterobacteria phage 186] ContigS from gb|AAC34167.l] (U32222) similar to P2 tail tube

SΞQ ID n^» 8870 PL-3643.1 3487722 to p 75= protein Fil, Swiss-Prot Accession

3488237

Number P22502 [Enterobacteria phage 186] prf | |2122413B tail tube protein [Bacteriophage

186] SEQ ID n~2832

Contig9 from gb | AAC02075 . l ] (AF043239) unknown [Salmonella

SEQ ID n° 8871 PL-6145.1 3488264 to p 643 typhimurium]

3488581 #N/A

Contig9 from ref |NP_046780.1 | gpE+E' [Bacteriophage P2]

SEQ ID n° 8872 PL-6144.1 3488596 to 653 gb|AAD03292.l| (AF063097) gpE+E ' [Bacteriophage

3488715 P2] #N/A

ContigS from gb|AAG56919.l|AE005413_13 (AE005413) putative

SEQ ID n° 8873 PL-834.1 3488636 to 333 tail fiber component of prophage CP-933T

3491134 [Escherichia coli 0157 :H7] SEQ ID n~3675

Contig9 from ref |NP_052274.l| F protem [Enterobacteria phage

SEQ ID n° 8874 PL-3641.1 3491137 to 703 186] gb|AAC34171.l| (U32222) F protein

3491601 [Ξnterobacteria phage 186] SEQ ID n~2831 ref |NP_052275.l| D protein [Enterobacteria phage

Contig9 from

186] sp|P21679 | PD_BP186 LATE CONTROL GENE D

SΞQ ID n° 8875 PL-835.1 3491598 to 663 PROTEIN (GPD) gb |AAC34172.1 | (U32222) D protein

3492683

[Enterobacteria phage 186] SEQ ID n~3676

Contig9 from gb|AAC48864.l| (U49731) late gène activator Pag

SEQ ID n° 8876 PL-6143.1 3492760 to 61% [Bacteriophage PSP3]

3492981 #N/A gb]AAG22005.l|AF282316_l (AF282316) aspartate semialdehyde dehydrogenase [Yersinia

ContigS from pseudotuberculosis] gb| AG22006.1 | AF282317_1 SEQ ID n° 8877 PL-836.1 3493188 to p 87% (AF282317) aspartate semialdehyde dehydrogenase

3494297 [Yersinia pseudotuberculosis] gb|AAG22007.l|AF282318_l (AF282318) aspartate semialdehyde dehydrogenase [Yersinia pestis] SEQ ID n~3677

Contig9 from gb|AAG58551.l|AΞ005568_l (AE005568) orf;

SΞQ ID n° 8878 PL-837.1 3494464 to 313 hypothetical protein [Escherichia coli 0157 :H7]

3495219 SEQ ID n~3678

Contig9 from gb|AAG54517.l|AE005197_6 (AE005197) Z0248 gène

SEQ ID n° 8879 PL-3640.1 3496338 to m 66% product [Escherichia coli 0157.-H7]

34S6817 SEQ ID n~2830

ContigS from sp|P06982|GYRB ECOLI DNA GYRASE SUBUNIT B

SEQ ID n° 8880 PL-838.1 3496958 to m 903 emb|CAA27871.l| (X04341) gyrase B (AA 1-804)

3499372 [Escherichia coli] SEQ ID n~3679

Contig9 from sp]P22839|RECF_PROMI RECF PROTEIN pir|| Q0735

SEQ ID n° 8881 PL-839.1 3 99^"3^""92 to m 83% recF protein - Proteus mirabilis gb|AAA83960. l|

3500483 (M58352) putative [Proteus mirabilis] SEQ ID n~3680 sp|P00583|DP3B_BCOLI DNA POLYMERASE III, BETA

CHAIN pir] |DJEC3B DNA-directed DNA polymerase

(EC 2.7.7.7) III beta chain - Ξscherichia coli pdb|2POL|A Chain A, Pol lii (Beta Subunit) .(E.C.2.7.7.7) pdb|2POL|B Chain B, Pol lii (Beta Subunit) (E.C.2.7.7.7)

Contig9 from gb|AAB59150.l| (J01602) DNA polymerase III beta-

SΞQ ID n° 8882 PL-840.1 3500505 to 91% subunit [Escherichia coli] gb|AAA6 052.l|

3501605 (L10328) DNA polymerase III beta-subunit [Escherichia coli] gb|AAC76724.l| (AE000447) DNA polymerase III, beta-subunit [Escherichia coli K12] gb|AAG58898.l|AΞ005601_4 (AE005601) DNA polymerase III, beta-subunit [Escherichia coli 0157 :H7] SEQ ID n~3682

Contig9 from sp|P 9440|DNAA_SΞRMA CHROMOSOMAL REPLICATION

SΞQ ID n° 8883 PL-841.1 3501610 to 93? INITIATOR PROTEIN DNAA gb| AA02924.1 | AAA02924

3502998 (M17353) DnaA [Serratia marcescens] SEQ ID n~3683

sp|P02437|RL34_ΞCOLI 50S RIBOSOMAL PROTEIN L34 pir] |R5ΞC34 ribosomal protein L34 [validated] -

__Ξscherichia coli emb] CAA2598 . l| (X01861) L34

(rpmH) (aa 1-46) [Escherichia coli] gb|AAB59148.l| (J01602) ribosomal protein L34

[Ξscherichia coli] gb|AAA24566 ,l| (M11056)

Contιg9 from ribosomal protein L34 [Ξscherichia coli] SEQ ID n° 8884 PL-6138.1 3503687 to 883 gb| AAA62054.l| (L10328) 50S ribosomal subunit

3503827 protein L34 [Ξscherichia coli] gb] AAC76726.1 |

(AE000447) 50S ribosomal subunit protein L34

[Escherichia coli ^" KÏ2] gb]AAG58900.l|AE005601_6 (AE005601) 50S ribosomal subunit protein L34 [Escherichia coli θl57:H7] prf | |763072A ribosomal protein L34

[Ξscherichia coli] #N/A sp|P22835|RNPA_PROMI RIBONUCLEAΞΞ P PROTEIN

Contig9 from COMPONΞNT (PROTEIN C5) (RNASE P) pir|]jQ0731 SEQ ID n° 8885 PL-6137.1 3503844 to 853 ribonuclease P (EC 3.1.26.5) protein component -

3504203 Proteus mirabilis gb| AAA83956.1 | (M58352)

RNaseP C5 subunit [Proteus mirabilis] #N/A

Sp|P22834[YIDD_PROMI HYPOTHETICAL S .6 KD PROTEIN

ContigS from

IN RNPA 3 'REGION pir] |JQ0730 9K protein - SEQ ID n° 8886 PL-6136.1 3504200 to 893

Proteus mirabilis gb]AAA83955. l| (M58352) ORF2 ;

3504427

9 kDa protein; putative [Proteus mirabilis] #N/A

Contigs from gb|AAG58902.l|AE005601_8 (AΞ005601) 60 KD inner- SEQ ID n° 8887 PL-842.1 3504430 to p 853 membrane protein [Escherichia coli 0157 :H7]

3506070 SEQ ID n~3684 sp|P25522|THDF_ECOLI THIOPHΞNΞ AND FURAN

OXIDATION PROTΞIN THDF pir||C65173 thiophene

ContigS from and furan oxidation 50 kD protein thdF - SEQ ID n° 8888 PL-843.1 3506317 to 903 Escherichia coli (strain K-12)

3507681 gb|AAC76729.l| (AE000447) GTP-binding protein in thiophene and furan oxidation

[Escherichia coli K12] SEQ ID n~3685

sp| 050224 |RECG_THIFE ATP-DΞPΞNDENT DNA HELICASE

Contig9 from RECG pir] |T45499 probable DNA recombinase recG

SEQ ID n° 8889 PL-844.1 3507915 to m 283 [imported] - Thiobacillus

3509135 ferrooxidans gb|AAC21662.l| (AF032884) RecG

[Acidithiobacillus ferrooxidans] SEQ ID n~3686

Contig9 from re |NP_053136.I| orf74 [Escherichia coli]

SEQ ID n° 8890 PL-845.1 ^~~3509162 to 433 dbj |BAA8490S.r| ^"(AB024946) orf74 [Escherichia

3511825 coli] SEQ ID n~3687

Contig9 from gb|AAG57162.l[AE005436_9 (AE005436) Z3269 gène

SEQ ID n° 8891 PL-6132.1 3511894 to m 47% _p_r<qduct [Escherichia coli 0157 :H7]

3512136 #N/A sp|P23873 |HIPB_ECOLI HIPB PROTEIN pir||A38112 hipB protein - Escherichia coli gb | AAA56877.1 |

(M61242) hipB [Escherichia coli] dbj |BAA15180.l| (D307S2) HipB protein

Contig9 from [Escherichia coli] dbj |BAA15188.l| (D90793) SEQ ID n° 8892 PL-6131.1 3512486 to 433 HipB protein [Escherichia coli] dbj |BAA15195. l|

3512791 (D90794) HipB protein [Ξscherichia coli] gb|AAC74581.l| (AE000248) persistenσe to inhibition of murein or DNA biosynthesis; regulatory protein [Ξscherichia coli K12] #N/A pir| |F64904 hipA protein - Escherichia coli

Contig9 from gb|AAC74580.l| (AE000248) persistence to

SEQ ID n° 8893 PL-846.1 35127S1 to 673 inhibition of murein or DNA biosynthesis,

3514110

DNA-binding regulator [Escherichia coli K12] SΞQ ID n~3688 pir||C81957 probable intégral membrane protein

NMA0408 [imported] - Neisseria

Contig9 from meningitidis (group A strain Z2491)

SΞQ ID n° 8894 PL-847.1 3514307 to m 533 emb|CAB83707.l| (AL162753) putative intégral

3515956 membrane protein [Neisseria meningitidis Z2491] SΞQ ID n~368S

sp | P14081 | SELB_ECOLI SΞLENOCYSTEINE-SPECIFIC

ΞLONGATION FACTOR (SELB TRANSLATION FACTOR) pir| |EFΞCSB translation _^elongation factor EF-

Contig9 from selB - Escherichia coli emb|CAA34637.1 |

SEQ ID n° 8835 PL-348.1 3516064 to m 733 (X16644) SEL B (AA 1-614) [Ξscherichia coli] 3517923 gb|AAC76614.l| (AE000436) selenocysteinyl-tRNA- specific translation factor

[Escherichia coli K12] prf | | 1602238A translation factor [Escherichia coli] SEQ ID n~3690 sp|P23328|SELA_ECOLI L-SERYL-TRNA(SEC) SELENIUM

TRANSFERASE (CYSTÉ^'INYL-TRNA(SEC)

Contig9 from SΞLENIUM TRANSFERASE) (SΞLENOCYSTΞINΞ SYNTHASE)

SEQ ID n° 8896 PL-849.1 3517957 to m 71% (SELENOCYSTEINYL-TRNA(SEC) SYNTHASE)

3519348 pir| | A38730 selA protein - Escherichia coli gb|AAA24624.l| (M64177) selenocysteine synthase

[Ξscherichia coli] SEQ ID n~3691

Contig9 from gb|AAG59084.l]AΞ005620_6 (AΞ005620) affects

SEQ ID n° 8897 PL-850.1 3519359 to 80% formate dehydrogenase-N [Escherichia coli

3520288 0157 :H7] SEQ ID n~3693 sp|P16559|TCMN_STRGA MULTIFUNCTIONAL CYCLASΞ-

DEHYDRATASΞ-3-O-MΞTHYL TRANSFΞRASΞ TCMN

Contig9 from pir| |S27696 tcmN protein - Streptomyces

SEQ ID n° 88S8 PL-851.1 3520802 to 333 glaucescens gb |AAA67518.1 | (M80674) possible

3521755 internai translational start site at position

9950; SAM binding site at position 10617 to

10636 [Streptomyces glaucescens] SEQ ID n~3694

Contig9 from gb|AAG51615.l|AC010795_20 (AC010795) caffeic O-

SEQ ID n° 8899 PL-852.3 3522468 to 383 methyltransferase, putative; 68744-70102

3523421 [Arabidopsis thaliana] #N/A

pιr| |C81839 probable transposase for IS1655

NMA1481 [imported] - Neisseria meningitidis (group B strain MD58, group A_ contig9 from

Strain Z2491) emb|CAB84714.l| (AL162756)

SΞQ ID n° 8900 PL-6129.1 3523710 to p 583 putative transposase for IS1655 [Neisseria

3524678 meningitidis Z2491] emb | CAB84719.1 |

(AL162756) putative transposase for IS1655

[Neisseria meningitidis Z2491] #N/A

Contig9 from gb|AAG51676.l|AC010704_20 (AC010704) putative

SΞQ ID n° 8901 PL-4030.2 3525387 to 3ξ caffeic acid 3-0-methyltransferase; 41078-42528

3526340 [Arabidopsis thaliana] #N/A

Contig9 from gb|AAG51676. ,l|AC010704_20 (AC010704) putative

SΞQ ID n° 8902 PL-2730.2 3526970 to 383 caffeic acid 3-O-methyltransferase; 41078-42528

3527923 [Arabidopsis thaliana] SEQ ID n~2933

Contig9 from gb|AAG51616.l|AC010795_20 (AC010795) caffeic 0-

SΞQ ID n° 8903 PL-2729.1 3528845 to 31% methyltransferase, putative; 68744-70102

3529840 [Arabidopsis thaliana] SEQ ID n~2931 sp ] 3217 | FDOI_ECOLI FORMATE DEHYDROGΞNASE ,

CYTOCHROME B556 (FDO) SUBUNIT (FORMATE

DEHYDROGENASE-O GAMMA SUBUNIT) (FDH-Z GAMMA

SUBUNIT) (AEROBIC FORMATE

DEHYDROGENASE CYTOCHROME B556 SUBUNIT) pir[|S40836 formate dehydrogenase (ΞC 1.2.1.2) O

Contig9 from (aérobic) gamma chain - Ξscherichia SEQ ID n° 8904 PL-2728.1 3530241 to 74% coli gb|AAB03025.l| (L19201) formate

3530882 dehydrogenase-O gamma subunit [Ξscherichia coli] gb|AAD13 54.l| (AΞ000464) formate dehydrogenase, cytochrome B556 (FDO) subunit [Escherichia coli K12] gb | AG59085.1 | AE005620_7

(AE005620) formate dehydrogenase, cytochrome B556 (FDO) subunit [Escherichia coli

0157:H7] SEQ ID n~2930

sp|P32175|FDOH_ECOLI FORMATE DEHYDROGENASE-O,

IRON-SULFUR SUBUNIT (FORMATE

DEHYDROGENASE-O BETA SUBUNIT) (FDH-Z BETA

SUBUNIT) (AEROBIC FORMATE

Contig9 from DEHYDROGΞNASΞ IRON-SULFUR SUBUNIT) pir||S40837

SEQ ID n° 8905 PL-2727.1 3530879 to m 863 formate dehydrogenase (ΞC 1.2.1.2) O (aérobic)

3531808 beta chain- - ^' Ξscherichia coli gb| AAB03026.l| (L19201) formate dehydrogenase-O beta subunit [Ξscherichia coli] gb|AADi3 55.l|

(AΞ000464) formate dehydrogenase-o, iron-sulfur subunit [Escherichia coli K12] SBQ ID n~1929

Contig9 from gb|AAD13456.l| (AE000464) formate dehydrogenase-

SEQ ID n° 8906 PL-2726.1 3531819 to 91% O, major subunit [Escherichia coli

3534278 K12] SΞQ ID n-3.928

Contig9 from gb|AAD13456.l| (AΞ000464) formate dehydrogenase-

SEQ ID n° 8907 PL-2725.1 3534279 to 91% O, major subunit [Escherichia coli

3534866 K12] SΞQ ID n~2927

Contig9 from gb[AAG59088.l|AE005620_10 (AE005620) affects

SEQ ID n° 8908 PL-2724.1 3535064 to 733 formate dehydrogenase-N [Ξscherichia coli

3535894 0157 :H7] SEQ ID n~29 6

Contig9 from emb|CAB67714.l| (AJ271405) putative transferase

SEQ ID n° 8909 PL-2723.1 3536006 to 383 enzyme [Streptomyces rochei]

3536773 SEQ ID n~2925

Contig9 from gb|AAG57157.l|AE005436_4 (AE005436) putative

SEQ ID n° 8910 PL-2722.1 3537384 to 51% kinase [Escherichia coli 0157 :H7]

3538304 SEQ ID n~2924

Contig9 from emb|CAA63510.1 | (X92346) acrolide efflux

SEQ ID n° 8911 PL-2721.1 3538352 to 523 protein [Lactococcus lactis]

3539569 SEQ ID n~2923 pir] ]H70559 hypothetical protein Rvl634 -

Contig9 from

Mycobacterium tuberculosis (strain

SEQ ID n° 8912 PL-6127.1 3539671 to 453

H37RV) emb]CAB08887.l| (Z95554) hypothetical

3539832 protein Rvl634 [Mycobacterium tuberculosis] #N/A

pir| |G81857 hypothetical protein NMA1635

Contig9 from [imported] - Neisseria meningitidis SEQ ID n° .8913 PL-2720.2 3540052 to 68% (group A strain Z2491) emb|CAB84863 ,l|

3540993 (AL162756) hypothetical protein [Neisseria meningitidis Z2491] #N/A pir| |G81857 hypothetical protein NMA1635

Contig9 from [imported] - Neisseria meningitidis SEQ ID n° 8914 PL-6126.1 3541039 to 71% (group A strain Z2491) emb|CAB84863.l|

3541158 (AL162756) hypothetical protein [Neisseria meningitidis Z2491] #N/A

Contig9 from

SEQ ID n° 8915 PL-2719.1 3541685 to No Hits found

3542635 SEQ ID n~î920

Contig9 from

SEQ ID n° 8916 PL-7127.1 3542676 to m No Hits found

3542843 #N/A

Contig9 from

SEQ ID n° 8917 PL-4029.1 3543347 to No Hits found

3543814 SEQ ID n~3178

Contig9 from gb|AAB70880.l| (U66703) reverse transcriptase

SEQ ID n° 8918 PL-2718.1 3543866 to m 51% [Escherichia coli]

3545047 SEQ ID n~2919

Contig9 from

SEQ ID n° 8919 PL-6125.1 3545097 to p No Hits found

3545285 #N/A

ContigS from gb|AAG55936.l|AΞ005327_6 (AE005327) unknown

SEQ ID n° 8920 PL-6124.1 3545536 to 36% protein encoded by prophage CP-933C

3545730 [Escherichia coli 0157 :H7] #N/A

ContigS from ref |NP_046805.l| unknown [Pantoea citrea]

SEQ ID n° 8921 PL-4028.1 3545958 to 46% gb|AAC17959.l| (AF022806) unknown [Pantoea

3546389 citrea] SEQ ID n~3177

Contig9 from

SEQ ID n° 8922 PL-6123.1 3546650 to m No Hits found

3546823 #N/A

gb|AAA17980.l| (L11583) putative protein

Contig9 from [Pseudomonas putida] gb|AAA18510.1 | (L11585) SΞQ ID n° 8923 PL-6122.1 3546902 to 333 putative protein [Pseudomonas putida]

3547132 gb|AAD44274.l|AF151431_3 (AF151431) putative transposase [Pseudomonas putida] #N/A sp | P23839 | YICC_ECOLI PROTΞIN YICC pir||F65165

33.2 kD protein in dinD-rph intergenic région

Contig9 from

(orf x) - Escherichia coli (strain K- SΞQ ID n° 8924 PL-2717.1 3547091 to m 833

12) gb|AAA61997.l| (L10328) o287 [Escherichia

3547954 coli] gb|AAC76668.l| (AE000441) putative alpha hélix protein [Escherichia coli K12] SEQ ID n~î918

Contig9 from sp|P03842|RNPH_ECOLI RIBONUCLEASE PH (RNASE PH) SEQ ID n° 8925 PL-2716.1 3548081 to 87% (TRNA NUCLEOTIDYLTRANSFERASΞ)

3548809 SEQ ID n~2917 sp | PO 8870 | PYRE_SALTY OROTATE

PHOSPHORIBOSYLTRANSFERASE (OPRT) (OPRTASE) pir||S32801 orotate phosphoribosyltransferase

(EC 2.4.2.10) pyrE [validated] -

Contig9 from

Salmonella typhimurium pdb|lOPR| Mol_id: 1; SΞQ ID n° 8926 PL-2715.1 3548894 to 82%

Molécule: Orotate Phosphoribosyltransferase;

3549535

Chain: Null; Synonym: Oprtase; Ec:

2.4.2.10; Engineered: Yes emb | CAA79607. l|

(Z19547) orotate phosphoribosyltransferase

[Salmonella typhimurium] SEQ ID n~i916 pir||C65l65 ttk protein - Escherichia coli gb|AAA61994.l| (L10328) 23 kD protein

Contig9 from [Escherichia coli] gb|AAC76665. l| (AE000441) SEQ ID n° 8927 PL-2714.1 3549595 to m 81% putative transcriptional regulator [Escherichia

3550194 coli K12] gb|AAG58785.l|AE005591_9

(AE005531) putative transcriptional regulator

[Ξscherichia coli 0157 :H7] SEQ ID n~2915

Contig9 from gb|AAG58784.l|AΞ005591_8 (AE005591) SΞQ ID n° 8928 PL-4025.1 3550435 to m 90% deoxyuridinetriphosphatase [Escherichia coli

3550893 0157:H7] SEQ ID n~3176

sp|P24285|DFP_ECOLI DNA/PANTOTHENATE METABOLISM

FLAVOPROTEIN pir| |A65165 pantothenate metabolism flavoprotein dfp - Ξscherichia coli

(Strain K-12) gb|AAC76663.l| (AE000441)

Contig9 from flavoprotein affecting synthesis of DNA and

SEQ ID n° 8929 PL-2713.1 3550871 to m 78% pantothenate metabolism [Escherichia 3552088 coli K12] gb|AAG58783Tl|AΞ005591_7 (AE005591) flavoprotein affecting synthesis of DNA and pantothenate metabolism [Escherichia coli 0157 :H7] SΞQ ID n~2914

Contig9 from gb|AAG58782.l|AΞ005591_6 (AΞ005591) DNA repair

SEQ ID n° 8930 PL-2712.1 3552287 to p 68% protein [Ξscherichia coli 0157 :H7]

3552979 SEQ ID n-1913 sp]P02428 |RL28_EC0LI 50S RIBOSOMAL PROTEIN L28 pir| |R5EC28 ribosomal protein L28 [validated] -

Escherichia coli gb|AAA74099. l| (J01677) ribosomal protein L28 [Escherichia coli]

Contig9 from gb|AAA61990.l| (L10328) 50S ribosomal subunit SEQ ID n° 8931 PL-6118.1 3553219 to p 873 protein L28 [Escherichia coli] gb| AC7666l.l|

3553455 (AE000441) 50S ribosomal subunit protein L28

[Escherichia coli K12] gb|AAG58781.l|AE005591_5 (AE005591) 50S ribosomal subunit protein L28 [Ξscherichia coli

0157 :H7] #N/A sp|P02436|RL33_ΞCOLI 50S RIBOSOMAL PROTEIN L33 pir| |R5EC33 ribosomal protein L33 [validated] -

Escherichia coli gb|AAA74100.l| (J01677) ribosomal protein L33 [Escherichia coli] gb|AAA6l989.l| (L10328) 50S ribosomal subunit

Contig9 from protein L33 [Escherichia coli] gb| AC76660.l| SEQ ID n° 8932 PL-6117.1 3553467 to 943

(AE000441) 50S ribosomal subunit protein L33

3553634

[Escherichia coli K12] gb|AAC01772.l|

(U23405) L33 [Salmonella typhimurium] gb|AAG58780.l|AE005591_4 (AE005591) 50S ribosomal subunit protein L33 [Escherichia coli

0157:H7] #N/A

pir| |A82676 conserved hypothetical protein

Contig9 from XF1470 [imported] - Xylella SEQ ID n° 8933 PL-2711.1 3553805 to p 44% fastidiosa (strain 9a5c)

3554326 gb|AAF84279.l|AE003977_2 (AE003977) conserved hypothetical protein [Xylella fastidiosa] SEQ ID n~2912

ContigS from gb|AAD37767.l|AF146532_7 (AF146532) putative SEQ ID n^"°^" 8934^"T?L-2710.1 3555114 to p 39% heptosyl III transferase WaaQ [KlebsiëTTa

3556136 pneumoniae] SEQ ID n~2911 pir||F71196 probable hexosyltransferase (EC

Contig9 from 2.4.1.-) PH1844 - Pyrococcus SEQ ID n° 8935 PL-2709.1 3556117 to p 33% horikoshii dbj |BAA30S65.l| (AP000007") 381aa

3557235 long hypothetical protein [Pyrococcus horikoshii] SEQ ID n~2909

ContigS from emb|CAB58324.l| (AL121855) hypothetical protein SEQ ID n° 8936 PL-2708.1 3557216 to p 31% SCF62.0S [Streptomyces coelicolor

3558391 A3 (2)] SEQ ID n-2908 sp|P2647l|RFAL_SALTY O-ANTIGEN LIGASE

Contig9 from pir] |B41317 0-antigen ligase complex protein SΞQ ID n° 8937 PL-2707.1 3558425 to m 57% rfaL - Salmonella typhimurium gb|AAA27206. l|

3559651 (M73826) O-antigen ligase [Salmonella typhimurium] SEQ ID n~2907

Contig9 from gb|AAG58779.l|AΞ005591_3 (AΞ005591) SEQ ID n° 8938 PL-2706.1 3559762 to p 83% formamidopyrimidine DNA glycosylase [Ξscherichia

3560571 coli 0157 :H7] SΞQ ID n~2906 sp | Q9X980 | COAD_SERMA PHOSPHOPANTETHEINE

Contig9 from ADENYLYLTRANSFΞRASΞ (PANTETHΞINE-PHOSPHATE SΞQ ID n° 8939 PL-4024.1 3560650 to m 75% ADΞNYLYLTRANSFΞRASΞ) (PPAT) (DΞPHOSPHO-COA

3561135 PYROPHOSPHORYLASE) gb |AAD28804.1 | (U52844) KdtB

[Serratia marcescens] SEQ ID n~3175 sp|Q54435|KDTX_SERMA LIPOPOLYSACCHARIDΞ CORE

Contig9 from

BIOSYNTHESIS GLYCOSYL TRANSFERASE KDTX SEQ ID n° 8940 PL-2705.1 3561132 to m 75% gb|AAC44433.l| (U52844) glucosyl transferase

3561905

[Serratia marcescens] SEQ ID n~2905

Contig9 from gb|AAC44432.l| (U52844) 3-deoxy-manno- SΞQ ID n° 8941 PL-2704.1 3561906 to m 83% octulosonic acid transferase [Serratia

3563183 marcescens] SEQ ID n~2904

Contig9 from gb(AAD37767.l|AF146532_7 (AF146532) putative SEQ ID n° 8942 PL-2703.1 3563412 to 633 heptosyl III transferase WaaQ [Klebsiella 3564476 pneumoniae] SEQ ID n~ÎS03 Contig9 from gb|AAD28801.l] (U52844) putative SΞQ ID n° 8943 PL-2702.1 3564473 to 803 glycosyltransferase [Serratia marcescens]

3565603 SEQ ID n~2902

Contig9 from gb|AAD28802.l] (U52844) putative

SEQ ID n° 8944 PL-2701.1 3565600 to 603 glycosyltransferase [Serratia marcescens]

3566703 SEQ ID n~2901 Contig9 from

SΞQ ID n° 8945 PL-2700.1^{" "} 3566971 to No Hits found

3567930 SEQ ID n~2900 sp ] P24173 | RFAC_ECOLI LIPOPOLYSACCHARIDE

HΞPTOSYLTRANSFΞRASE-1 pir] |A40619 lipopolysaccharide heptosyltransferase (EC

2.4.99.-) I rfaC [similarity] -

Contig9 from

Ξscherichia coli emb| CAA44391. l| (X62530) rfa-2

SΞQ ID n° 8946 PL-2699.1 3568055 to 723

[Escherichia coli] gb|AAB18598.l| (U0003S)

3569020 alternate gène name rfa2 [Bscherichia coli] gb|AAC76645.l| (AΞ000440) heptosyl transferase

I; lipopolysaccharide core biosynthesis [Ξscherichia coli K12] SEQ ID n-2.897

Contig9 from gb|AAD37762.l|AF146532_2 (AF146532) heptosyl II SΞQ ID n° 8947 PL-2698.1 3569020 to m 833 transferase WaaF [Klebsiella pneumoniae]

3570069 SEQ ID n~1896

sp|P17963 |RFAD_ECOLI ADP-L-GLYCERO-D-MANNO-

HΞPTOSΞ-6-ΞPIMERASΞ (ADP-GLYCΞROMANNO-HEPTOSΞ

6-ΞPIMΞRASΞ) pir| | JU0299 ADPglyceromanno- heptose 6-epimerase (EC 5.1.3.20) rfaD

[validated] - Ξscherichia coli emb|CAA38364.l| (X54492) acidic 34,893Da HtrM

Contig9 from protein [Escherichia coli] gb|AAA24525.l| SΞQ ID n° 8948 PL-2637.1 3570080 to m 73% (M33577) rfaD protein [Escherichia coli]

3571018 gb]AAB18596.l| (U00039) ADP-L-Glycero-D- mannoheptose-6-epimerase [Escherichia coli] gb|AAC76643.l| (AΞ000^"440) ADP-L-glycero-D- mannoheptose-6-epimerase [Escherichia coli K12] gb|AAG58766.l|AΞ005590_l (AΞ005590)

ADP-L-glycero-D-mannoheptose-6-epimerase

[Escherichia coli 0157 :H7] SEQ ID n~2895 sp | P07912 | KBL_EC0LI 2 -AMINO-3 -KETOBUTYRATΞ

COENZYME A LIGASE (AKB LIGASB) (GLYCINE

ACETYLTRANSFERASE) pir] |XUECGA glycine C- acetyltransferase (EC 2.3.1.29) - Escherichia coli gb|AAB18594.l| (U00039) glycine

ContigS from acetyltransferase [Escherichia coli]

SEQ ID n° 8943 PL-2636.1 3571253 to 90% gb|AAC7664i.l| (AE000439) 2-amino-3-ketobutyrate

3572449

CoA ligase (glycine acetyltransferase) [Escherichia coli K12] gb|AAG58764.l|AE005589_4 (AE005589) 2-amino-3- ketobutyrate CoA ligase (glycine acetyltransferase) [Escherichia coli 0157 :H7] SEQ ID n-2894 sp | PO 7913 | TDH_ΞC0LI THRΞONINE 3 -DEHYDROGENASΞ pir| |DΞECTH L-threonine 3 -dehydrogenase (EC

Contig9 from 1.1.1.103) - Escherichia coli emb | CAA2988 .1 | SEQ ID n° 8950 PL-2695.1 3572459 to 95% (X06690 ) tdh gène [Escherichia coli]

3573484 gb| AAB18593.1 | (U00039) threonine dehydrogenase

[Bscherichia coli] gb]AAC76640.1 | (AΞ000439) threonine dehydrogenase [Escherichia coli K12] SEQ ID n~2893

pir| |H82128 3 -oxoacyl- (acyl-carrier-protein) synthase III VC2023 [imported] -

Contig9 from

Vibrio cholerae (group 01 strain N16961) SEQ ID n° 8951 PL^~2^"6^"9TE7T^" 3573773 to m 423 gb|AAF95l7i.l| (AE004276) 3 -oxoacyl- (acyl-

3574834 carrier-protein) synthase III [Vibrio cholerae] SEQ ID n~2892

Contig9 from

SEQ ID n° 8952 PL-6115.1 3575483 to No Hits found

3575587 #N/A pir| |F75337 transposase - Deinococcus

Contig9 from radiodurans (strain RI)

SEQ ID n° 8953 PL-4023.1 3575707 to 623 gb|AAF11477.l|AE002031_6 (AE002031) transposase

3576135

[Deinococcus radiodurans] SEQ ID n~3174

Contig9 from gb[AAG58761.l|AE005589_l (AE005589) yibQ gène

SEQ ID n° 8954 PL-2693.1 3576182 to 61% product [Escherichia coli 0157.-H7]

3576997 SΞQ ID n~2891

Contig9 from sp|P37690|YIBP_ΞCOLI HYPOTHETICAL 46.6 KD

SEQ ID n° 8955 PL-2692.1 3576987 to 713 PROTEIN IN SΞCB-TDH INTERGENIC REGION

3578294 SEQ ID n~2830 sp|P37688|YIBN_BCOLI HYPOTHΞTICAL 15.6 KDA

PROTEIN IN SΞCB-TDH INTERGENIC REGION pir]|S47832 hypothetical 15.6K protein (secb-tdh

Contig9 from intergenic région) - Ξscherichia coli SEQ ID n° 8956 PL-4021.1 3578843 to 71% gb|AAB18588.l| (U00039) No définition line found

3579280 [Ξscherichia coli] gb|AAC76635.l| (AE000439) orf, hypothetical protein [Escherichia coli K12] gb|AAG58758.l|AE005588_9 (AE005588) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~3173

sp|P15040|SΞCB_ΞCOLI PROTEIN-EXPORT PROTEIN SECB pir[ |VXΞCS protein-export protein secB -

Escherichia coli gb | AAA83907.1] (M24489) export protein [Escherichia coli] gb |AAB18586.1 |

Contig9 from (U00039) CG Site No. 17896 [Escherichia coli] SΞQ ID n° 8957 PL-4020.1 3579350 to 863 gb|AAC76633.l| (AE000439) protein export;

3579826 ^"" molecular chaperone^"; may bind to signel séquence [Escherichia coli K12] gb|AAG58756.l|AΞ005588_7 (AΞ005588) protein export ; molecular chaperone; may bind to signel séquence ^"[Escherichia coli 0157:H7] SEQ ID n~317^"2 sp | 37606 | GPDA_ΞCOLI GLYCEROL-3 -PHOSPHATE

DEHYDROGENASE [NAD+] pir| |S47829 glycerol-3- phosphate dehydrogenase (NAD+) (EC 1.1.1.8) -

Escherichia coli gb|AAB18585.l| (U00039) L-

Contig9 from glycerol 3 -phosphate dehydrogenase [Escherichia SΞQ ID n° 8958 PL-2691.1 3579826 to 86% coli] gb|AAC76632.l| (AE000439) glycerol-3-

3580848 phosphate dehydrogenase (NAD+) [Escherichia coli K12] gb]AAG58755.l|AE005588_6 (AE005588) glycerol-3 -phosphate dehydrogenase (NAD+)

[Escherichia coli 0157 :H7] SEQ ID n~2889 sp|P05796|CYSΞ_ECOLI SERINE ACETYLTRANSFFRASE

(SAT) pir| |XYECSA serine O-acetyltransferase

(EC 2.3.1.30) - Escherichia coli gb| AAA23648.l|

(M15745) serine acetyltransferase [Ξscherichia

Contig9 from coli] gb|AAA23659.l| (M34333) 33 Kd protein SΞQ ID n° 8959 PL-2690.1 3580892 to 883 (cysE) [Escherichia coli] gb|AABl8584.l|

3581713 (U00039) serine acetyltransferase [Escherichia coli] gb|AAC76631.l| (AE000438) serine acetyltransferase [Escherichia coli K12] gb|AAG58754.l|AE005588_5 (AE005588) Serine acetyltransferase [Ξscherichia coli 0157 :H7] SEQ ID n~2888

pir| ]C64572 conserved hypothetical protein

Contig9 from HP0419 - Helicobacter pylori (strain SEQ ID n° 8960 PL-2689.1 3581938 to m 333 26635) gb|AAD07484.l| (AE000557) conserved

3582657 hypothetical protein [Helicobacter pylori

26695] SEQ ID n~2886 Contig9 from

SEQ ID n° 8961 PL-6112.1 3582935 to No Hits found

3583165 #N/A sp|P33899|YIBK_EC0LI HYPOTHΞTICAL TRNA/RRNA METHYLTRANSFERASE YIBK pir | |S47827 yibK protein Contig9 from - Escherichia coli gb |AAB18583.l| (U00039)

SEQ ID n° 8962 PL-4019.1 3583204 to 74% alternate gène name yibK [Escherichia coli]

3583710 gb|AAC76630.l] (AE000438) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~3170

Contig9 from SEQ ID n» 8963 PL-2688.1 3583891 to m No Hits found

3584589 SEQ ID n~2885 Contig9 from gb|AAG54897.l|AE005235_4 (AE005235) putative SEQ ID n° 8964 PL-6111.1 3584809 to m 40% receptor [Escherichia coli 0157 :H7]

3585060 #N/A Contig9 from gb|AAK02370.l| (AEO 06063) GalΞ [Pasteurella SEQ ID n° 8965 PL-2687.1 3585202 to m 803 multocida]

3586224 SEQ ID n~£884 pir| |H82888 methionyl-tRNA formyltransferase

Contig9 from UU463 [imported] - Ureaplasma SEQ ID n° 8966 PL-2686.1 3586425 to 32% urealyticum gb|AAF30875.l| AΞ002142_9 (AE002142)

3587597 methionyl-tRNA formyltransferase [Ureaplasma urealyticum] SEQ ID n~2883 pir||C8l839 probable transposase for IS1655

NMA1481 [imported] - Neisseria meningitidis (group B strain MD58, group A

Contig9 from strain Z2491) emb [ CAB8471 .1 | (AL162756) SEQ ID n° 8967 PL-6108.1 3588134 to 543 putative transposase for IS1655 [Neisseria

3588475 meningitidis Z2491] emb|CAB84719. l|

(AL162756) putative transposase for IS1655

[Neisseria meningitidis Z2491] #N/A

Contig9 from gb|AAC987 0.l| (AF052750) transposase SEQ ID n° 8968 PL-7123.1 3588877 to m 51% [Pseudomonas putida]

3589008 #N/A Contig9 from gb|AAC98740.l| (AF052750) transposase

SEQ ID n° 8969 PL-4018.1 3589056 to m 63% [Pseudomonas putida]

3589526 SEQ ID n~316 Contig9 from gb|AAD29044.l|AF130439_4 (AF130439) transposase

SEQ ID n° 8970 PL-6107.1 3589638 to m 56% [Pseudomonas putida]

3589817 #N/A Contig9 from gb|AAK03811.l| (AE006210) unknown [Pasteurella. SEQ ID n° 8971 PL-4017.1 3589869 to m 58% multocida]

3590420 SEQ ID n~316 pir] |G81287 probable sugar-phosphate nucleotidyltransferase Cj 1423c [imported]

Contig9 from - Campylobacter jejuni (strain NCTC 11168) SEQ ID n° 8972 PL-2685.1 3590402 to m 62% emb|CAB73847.l| (AL139078) putative sugar-

3591079 phosphate nucleotidyltransferase [Campylobacter jejuni] SEQ ID n-288 pir| |H81287 probable phosphoheptose isomerase

Contig9 from Cj 1424c [imported] - Campylobacter SEQ ID n° 8973 PL-2684.1 3591083 to m 72% jejuni (strain NCTC 11168) emb[CAB73848. l|

3591673 (AL139078) putative phosphoheptose isomerase [Campylobacter jejuni] SEQ ID n~188 pir| |A81288 probable sugar kinase Cjl425c

Contigθ from [imported] - Campylobacter jejuni SEQ ID n° 8974 PL-2683.1 3591661 to m 62% (strain NCTC 11168) emb]CAB7384S.l [ (AL13S078)

3592689 putative sugar kinase [Campylobacter jejuni] SEQ ID n~288

ContigS from gb[AAG35360.l|AF317224_2 (AF317224) GDP-mannose SEQ ID n° 8975 PL-6105.1 3593313 to m 43% 4, -dehydratase [Aneurinibacillus

3593558 thermoaerσphilus] #N/A ContigS from gb|AAD50490.l|AF172324_8 (AF172324) WbnE SEQ ID n° 8976 PL-2682.1 3593566 to m 38% [Escherichia coli]

3594675 SEQ ID n~£87 Contig9 from dbj |BAB07433.l| (AP001519) exopolysaccharide SEQ ID n° 8977 PL-2681.2 3594685 to m 37% biosynthesis [Bacillus halodurans]

3595533 #N/A

Contig9 from gb[AAC60769.l[ (U46859) WbcF [Yersinia SEQ ID n° 8978 PL-6998.1 3595987 to m 583 enterocolitica (type 0:8)]

3596988 #N/A Contig9 from gb|AAC60768.l| (U46859) WbcE [Yersinia

SEQ ID n° 8979 PL-4635.1 3596985 to m 50% enterocolitica (type 0:8)]

3598013 #N/A

Contig9 from__ pir| |A44396 P-type catiorî^trans oσating ATPase -

SEQ ID n° 8980 PL-4636.1 3597991 to m 35% malaria parasite (Plasmodium

3599271 falciparum) #N/A Contig9 from dbj |BAB06239.11 (AP00jL_515) transposase related

SΞQ ID n° 8981 PL-2493.3 3599413 tθ_ m 20% protein (20) [Bacillus halodurans]

3600438 #N/A gb|AAF33461.l| (AF233324) 83% identity with E.

Contig9 from coli lipopolysaccharide biosynthesis SEQ ID n° 8982 PL-2494.1 3600752 to m 49% protein (WZXΞÎ (SP:P2783) [Salmonella

3601957 typhimurium LT2] SΞQ ID n~i67

Contig9 from gb|AAB81632.l[ (AF025396) putative amino SBQ ID n° 8383 PL-2495.1 3602002 to ^" m 74% transferase [Vibrio anguillarum]

3603129 SΞQ ID n~∑67 sp [ P27831 |RFFH_ΞCOLI GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASΞ (DTDP-GLUCOSE SYNTHASE) (DTDP-GLUCOSE PYROPHOSPHORYLASE) pir| |H65182

ContigS from glucose-1-phosphate thymidylyltransferase (EC SEQ ID n° 8984 PL-2496.1 3603585 to m 82%

2.7.7.24) - Escherichia coli

3604457 gb|AAC767S4.l| (AE000455) glucose-1-phosphate thymidylyltransferase [Escherichia coli K12] SEQ ID n~268 sp|P14182 |LICB_HAEIN LICB PROTEIN pir||C64128

Contig9 from lic-1 operon protein (licB) homolog - SEQ ID n° 8985 PL-2497.1 3605233 to m 523 Haemophilus influenzae (strain Rd

3606192 KW20) gb|AAC23188.l| (U32829) lic-1 operon protein (licB) [Haemophilus influenzae Rd] SEQ ID n~268

pir| |T44517 trsG protein homolog [imported]

Contig9 from Plesiomonas shigelloides dbj |BAA85014.l| SΞQ ID n° 8986 PL-2498.1 3606602 to m 73% (AB025970) ORF3P [Plesiomonas shigelloides]. _ - _ 3608476 ^"gb|AAG17 16.l|AF285970_10 (AF285370) WbgZ [Plesiomonas shigelloides] SEQ ID n~26

Contig9 from

_ b |AAG17415.11AF285970_9 (AF285970)— bgY~ SΞQ ID n° 898_7.P_L=2499.1 3608486 to m 76% [Plesiomonas shigelloides]

3609097 SEQ ID n-26 Contig9 from gb|AAG17414.l|AF285970_8 (AF285970) WbgX SΞQ ID n° 8988 PL-2500.1 3609098 to 843 [Plesiomonas shigelloides]

3610255 SEQ ID n~26 Contig9 from gb|AAG17423.l|AF285971_7 (AF285971) WbgW SΞQ ID n° 8989 PL-2501.1 3610266 to m 533 [Shigella sonnei]

3611276 SEQ ID n~26 Contig9 from emb|CAA07667.l| (AJ007747) putative transferase SEQ ID n° 8990 PL-2502.1 3611446 to m 613 [Bordetella bronchiseptica]

3612684 SΞQ ID n~£6 pir||C83253 probable UDP-N-acetylglucosamine 2- epimerase Wbpl PA3148 [imported]

Contig9 from

Pseudomonas aeruginosa (strain PAOl) SEQ ID n° 8991 PL-2503.1 3612681 to m 72% gb[AAG06536.l|AE00 738_10 (AE004738) probable

3613751

UDP-N-acetylglucosamine 2 -epimerase Wbpl

[Pseudomonas aeruginosa] SEQ ID n~26 pir| |D83253 probable glycosyltransferase WbpH

PA3149 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) gb|AAC45862.l| SEQ ID n° 8992 PL-2504.1 3613757 to 75% (U50396) WbpH [Pseudomonas aeruginosa]

3614860 gb|AAG06537.l|AE004738__ll (AE004738) probable glycosyltransferase WbpH [Pseudomonas aeruginosa] SΞQ ID n~î6

Contιg9 from SEQ ID n° 8993 PL-2505.1 3614857 to m No Hits found

3616086 SEQ ID n~26

sp|P46555|YKG5_CAΞΞL HYPOTHETICAL 71.9 KD

SΞQ ID n° 8994 PL-2506.1

elegans] SEQ ID n~26_92_ pir| |C83251 O-antigen translocase PA3153

[imported] - Pseudomonas aeruginosa

Contig9 from

(strain PAOl) gb| AAC45858. l| (U50396) WbpF SEQ ID n° 8995 PL-2507.1 3617190 to m

[Pseudomonas aeruginosa] -3618407 gb|AAG06541.l|AE004739_3 (AE004739) O-antigen translocase [Pseudomonas aeruginosa] SΞQ ID n~î693 pir||Ξ83251 probable aminotransferase WbpE

ContigS from PA3155 [imported] - Pseudomonas SEQ ID n° 8S36 PL-2508.1 3618413 to m 823 aeruginosa (strain PAOl)

3613483 gb|AAG06543.l| AEO 04739_5 (AEO 04739) probable aminotransferase WbpE [Pseudomonas aeruginosa] SEQ ID n~2694 pir||S70673 acetyl transferase homolog -

Bordetella pertussis emb|CAA62246.l| (X90711)

Contig9 from gène referred to as bplB in Mol. Microbiol. SEQ ID n° 8997 PL-3217.1 3619498 to m 773 19:37-52(1996) [Bordetella pertussis]

3620085 emb|CAA07670.l| (AJ007747) putative acetyltransferase [Bordetella bronchiseptica] prf | |2210367D bplB gène [Bordetella pertussis] SEQ ID n~2470

Contig9 from gb(AAD45293.l|AF156256_l (AF156256) putative SEQ ID n° 8998 PL-2509.1 3620104 to m 71% dehydrogenase [Vibrio anguillarum]

3621153 SEQ ID n~2695 pir] |A83252 probable UDP-glucose/GDP-mannose dehydrogenase WbpA PA3159 [imported]

Contig9 from Pseudomonas aeruginosa (strain PAOl) SEQ ID n° 8399 PL-2510.1 3621168 to m 823 gb|AAC45852.l| (U50396) WbpA [Pseudomonas

3622478 aeruginosa] gb| AAGO6547.1|AE0O473S__9 (AE004739) probable UDP-glucose/GDP-mannose dehydrogenase

WbpA [Pseudomonas aeruginosa] SEQ ID n~î697

sp|P08336|CPXA_ECOLI SENSOR PROTEIN CPXA pir| |S40855 chemotaxis protein cpxA (EC 2.7.3.-) . ContigS from - Escherichia coli gb| AB03044.l| (L19201) CG

SEQ ID n° 9000 PL-2511.1 3622880 to m 873 Site No. 908 [Escherichia coli] gb|AAC76893.l|

3624250 (AE000466) probable sensor protein (histidine

protein kinase) , acting on arc

[Ξscherichia coli K12] SEQ ID n~2698 s | 16244 | CPXR_ECOLI TRANSCRIPTIONAL REGULATORY

PROTEIN CPXR pir |] 153679 transcription factor -

Escherichia coli pir||C65197 transcription regulator cpxR - Ξscherichia coli (strain κ-12) gb|AAC36868.l| (L14579) transcription factor

ContigS from

[Ξscherichia coli] gb]AAC76894.l| (AE000466) SΞQ ID n° 9001 PL-2512.1 3624247 to m 923 transcriptional regulator in 2-component system

3624942

[Escherichia coli K12] gb| AAG59106.ι|AEθθ5622_8

(AEO05622) transcriptional regulator in 2- σomponent system [Escherichia coli

0157 :H7] prf | |2004283A membrane sensor regulator [Escherichia coli] SEQ ID n~1699 pir||S40857 hypothetical protein ol67 -

Contig9 from Escherichia coli gb|AAB03046.l| (L19201) SEQ ID n° 9002 PL-3218.1 3625100 to p 52% ORF_O167 [Escherichia coli]

3625594 gb|AAG59107.l|AΞ005622_3 (AE005622) yiiO gène product [Escherichia coli 0157 :H7] SΞQ ID n~2471

Contig9 from emb|CAB54522.l| (AJ245S59) Int protein SEQ ID n° 9003 PL-3219.1 3625837 to m 65% [Bacteriophage WPhi]

3626271 SEQ ID n~2472 gb|AAG58617.l|AE005572_15 (AE005572) Z4883 gène

ContigS from product [Escherichia coli 0157 :H7 EDL933] SEQ ID n° 9004 PL-6997.1 3626284 to p 54% dbj |BAB37780.l| (AP002565) HicA-like protein

3626460

[Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG58616.l|AE005572_14 (AE005572) Z4882 gène SΞQ ID n° 9005 PL-4645.1 3626453 to p 65% product [Escherichia coli 0157 :H7]

3626800 #N/A

Contig9 from emb |CAB5 522.1] (AJ245959) Int protein SΞQ ID n° 9006 PL-4646.1 3627288 to m 83% [Bacteriophage WPhi] 3627710 - #N/A.

ContigS from ref |NP_046787.l| gpC [Bacteriophage P2] SΞQ ID n° 9007 PL-4648.1 3627732 to m 46%

gb|AAD03298.l| (AF063097) gpC [Bacteriophage P2] 3627920 pir| | JC4694 proteic killer active protein hig B

ContigS from plasmid Rtsl gb| AAC43983.l| (U43847) antidote SEQ ID n° 9008 PL-4649.1 3627945 to m 75% protein [Plasmid Rtsl] gb|AAD00516. l| (U81366)

3628259 antidote protein [Plasmid Rtsl] prf | |2210234B higA gène [Escherichia coli] #N/A pir| |JC4693 proteic killer suppression protein

Contig9 from hig A - plasmid Rtsl gb| AAC43982.l| (U43847) SEQ ID n° 9009 PL-4650.1 3628259 to m 18 ' killer protein [Plasmid Rtsl] gb| AAD00515.l|

3628411 (U81366) killer protein [Plasmid Rtsl] prf | |2210234A higB gène [Escherichia coli] #N/A pir| | JC4693 proteic killer suppression protein

ContigS from hig A - plasmid Rtsl gb| AC43982.l| (U43847) SEQ ID n° 9010 PL-4651.1 3628353 to m 62% killer protein [Plasmid Rtsl] gb|AAD00515.1 |

3628538 (U81366) killer protein [Plasmid Rtsl] prf | | 2210234A higB gène [Escherichia coli] #N/A

Contig9 from gb|AAG54758.l|AΞ005220_7 (AE005220) unknown SEQ ID n° 9011 PL-4653.1 3629323 to m 61% [Escherichia coli 0157:H7]

3629625 #N/A Contig9 from gb|AAG54757.l|AE005220_6 (AE005220) unknown SEQ ID n° 9012 PL-4654.1 3629618 to m 85% [Ξscherichia coli 0157 :H7]

3629860 #N/A Contig9 from SEQ ID n° 9013 PL-7121.1 3623961 to p No Hits found

3630095 #N/A Contig9 from gb|AAG55936.l|AΞ005327_6 (AE005327) unknown SEQ ID n° 9014 PL-4655.1 3630174 to p 423 protein encoded by prophage CP-933C

3630308 [Ξscherichia coli 0157 :H7] #N/A Contig9 from gb] AAF33487.1| (AF233324) hypothetical protein SEQ ID n° 9015 PL-4656.1 3630386 to m 753 predicted by Glimmer [Salmonella

3630724 typhimurium LT2] #N/A

gb|AAF33478.l[ (AF233324) contains similarity to

Contig9 from Bacteriophage N15 (GP 9) SΞQ ID n° 9016 PL-4657.1 3630721 to .m .5? (GB:AF064539) and Yersinia_pestis unfinished

3631038 genomic séquence (TBLASTX)

[Salmonella typhimurium LT2] #N/A

Contig9 from gb|AAD54236.l|AF153829~2^"—(AF153829) unknown SEQ ID n° 9017 PL-3220.1 3631318 to 71%

[Salmonella typhi]

3631725 SEQ ID n~2474 ref |NP_046344.l| gp48 [Bacteriophage N15]

Contig9 from pir| |T13135 protein gp48 - phage N15 SEQ ID n° 9018 PL-4659.1 3631925 to — m 42% gb|AACl3087.ι| (AF064539) gp48 [Bacteriophage

3632218

N15] #N/A ref |NP_046945.l| gp49 [Bacteriophage N15]

Contig9 from pir| ]T13136 protein gp49 - phage N15 SEQ ID n° 9019 PL-4660.1 3632227 to m 47? gb|AAC19088.l| (AF064539) gp49 [Bacteriophage

3632577

N15] #N/A pir| |G82138 CDP-diacylglycerol--glycerol-3- phosphate 3 -phosphatidyltransferase- related protein VC1935 [imported] -

Contig9 from

Vibrio cholerae (group Ol strain N16961) SEQ ID n° 9020 PL-2513.1 3633062 to p 48% gb|AAF95083.l| (AE004269) CDP-diaσylglycerol--

3633736 glycerol-3 -phosphate 3- phosphatidyltransferase-related protein [Vibrio cholerae] SEQ ID n~2700 pir| |B83329 probable acyltransferase PA2537

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 9021 PL-2514.1 3633729 to p 56? (strain PAOl) gb| AAG05925.l| E004681_7

3634370 (AE004681) probable acyltransferase [Pseudomonas aeruginosa] SEQ ID n~2.70l pir| |A83329 probable phosphatidate cytidylyltransferase PA2536 [imported] -

Contig9 from

Pseudomonas aeruginosa (strain PAOl) SΞQ ID n° 9022 PL-2515.1 3634367 to p 72% gb|AAG05924.l|AE004681_6 (AE004681) probable

3635311 phosphatidate cytidylyltransferase [Pseudomonas aeruginosa] SEQ ID n~2702

Contig9 from gb|AADl6l79.l| (AF098509) phosphofructokinase SEQ ID n° 9023 PL-2516.1 3635693 to p 86% [Enterobacter cloacae] 3636664 SEQ ID n~2703 pir| (S40860 periplasmic sulphate binding protein - Escherichia coli pir| |BYΞC sulfate binding

. Contig9 from protein precursor, periplasmic - Escherichia coli gb|AAB03049.ι| (L19201) periplasmic

SEQ ID n° 9024 PL-2517.1 3636836 to p 823 sulphate binding protein [Ξscherichia coli]

3637831 gb[ AAC76899.l| (AΞ000466) periplasmic sulf te- binding protein [Ξscherichia coli

K12] SEQ ID n~2704

Contig9 from sp|Q9Z6B9|TPIS_ENTCL TRIOSΞPHOSPHATΞ ISOMERASE SEQ ID n° 9025 PL-2518.1 3637884 to m 853 (TIM) gb|AAD16183.l| (AF098509) triose

3638651 phosphate isomerase [Enterobacter cloacae] SΞQ ID n~2705

Sp|P32160 |YIIQ_ΞCOLI HYPOTHETICAL 21.8 KD

PROTEIN IN TPIA-FPR INTERGENIC REGION

Contig9 from PRECURSOR pir] |S40863 hypothetical 21.8K SEQ ID n° 9026 PL-2519.1 3638786 to m 53% protein (tpia 3 'région) precursor - Escherichia

3639388 coli gb|AAB03052.l| (L19201) ORF_fl99

[Escherichia coli] gb |AAC76902.1 | (AE000466) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~2706 sp|P3216l|YIIR_ECOLI HYPOTHETICAL 16.5 KD

PROTEIN IN TPIA-FPR INTERGΞNIC REGION (0146) pir] |S40864 hypothetical 16.5K protein (tpia-fpr

Contig9 from intergenic région) - Escherichia coli SEQ ID n° 9027 PL-4661.1 3639456 to 683 gb|AAB03053.l] (L19201) 0RF_ol46 [Escherichia

3639830 coli] gb|AAC76903.l| (AΞ000466) orf, hypothetical protein [Escherichia coli K12] gb[AAG59114.1 |AE005623_5 (AE005623) orf, hypothetical protem [Escherichia coli 0157 :H7] #N/A

Contig9 from gb]AAG59117.l]AE005623_8 (AE005623) ferredoxin-

SEQ ID n° 9028 PL-2520.1 3639893 to 853 NADP reductase [Escherichia coli 0157:H7]

3640639 SΞQ ID n~1708 Contig9 from gb|AAG59119.l|AΞ005623_10 (AΞ005623) glycerol

SEQ ID n° 9029 PL-2521.1 3641048 to 89% kinase [Ξscherichia coli 0157 :H7]

3642571 SEQ ID n~2709

Contig9 from sp P31140|GLPF_SHIFL GLYCEROL UPTAKE FACILITATOR SEQ ID n° 9030 PL-2522.1 3642602 to 803 PROTΞIN

_ 3643.432 SΞQ ID n~2-73.-0 sp|P32164|YIIU_ΞCOLI HYPOTHΞTICAL 9.6 KD PROTEIN

IN GLPF-HSLU INTERGENIC RΞGION (081)

pir| |S4087l hyp.o.the.tical 9.6K protein (glpf-hslu

Contig9 from intergenic région) - Ξscherichia coli SEQ ID n° 9031 PL-4663.1 3643738 to p 583 gb|AAB03060.l| (L19201) 0RF_o8l [Escherichia

3643980 coli] gb|AAC76910.l| (AΞ000467) orf, hypothetical protein [Escherichia coli K12] gb|AAG59121.l|AE005623_12 (AE005623) orf, hypothetical protein [Ξscherichia coli 0157 :H7] #N/A sp | P32165 | MΞNG_EC0LI S-ADΞNOS LMETHIONINE : 2-

DEMΞTHYLMENAQUINONE METHYLTRANSFΞRASE pir| |s40872 2-demethylmenaquinone 2-C- ethyltransferase (EC 2.1.1.-) menG

[validated] - Escherichia coli gb| AAB03061.1 |

ContigS from (L19201) ORF_fl6l [Escherichia coli] SEQ ID n° 9032 PL-3222.1 3644041 to m 84% gb|AAB01208.l| (U56082) S-adenosylmethionine : 2-

3644550 demethylmenatquinone methyltransferase

[Escherichia coli] gb|AAC76311. l| (AE000467) menaquinone biosynthesis, unknown [Escherichia coli K12] gb(AAG59124.l|AE005623_15 (AΞ005623) menaquinone biosynthesis, unknown [Ξscherichia coli 0157 :H7] SEQ ID n~2476

Contig9 from gb]AAG59125.l|AE005624_l (AE005624) 1,4-

SΞQ ID n° 3033 PL-2523.1 3644700 to 743 dihydroxy-2 -naphthoate --> dimethylmenaquinone

3645617 [Escherichia coli 0157 :H7] SEQ ID n~2711

sp|P32168|HSLU_ECOLI ATP-DEPENDENT HSL PROTEASE

ATP-BINDING SUBUNIT HSLU (HEAT SHOCK

PROTEIN HSLU) pir | |JT0761 heat-shock-protein hslU - Escherichia coli gb| AB03063.l| (L19201) matches PS00017: ATP_GTP_A; similar to

Pasteurella haemoly_tlc_a hypoth.

Contig9 from protein ORFl; heat shock induced

SΞQ ID n° 9034 PL-2524.1 3645713 to m 91%

[Escherichia coli] gb | AAC76913. l| (AE000467)

3647044 heat shock protein hslVU, ATPase subunit, homologous to chaperqnes [Escherichia coli K12] gb|AAG59126.l|AE005624_2 (AΞ005624) heat shock protein hslVU, ATPase subunit, homologous to chaperones [Escherichia coli 0157 :H7] SΞQ ID n~2712

Contig9 from emb|CAC00719.l| (AJ295709) heat shock protein

SΞQ ID n° 9035 PL-3223.1 3647056 to 803 [Salmonella typhimurium]

3647586 SΞQ ID n~2477 sp|P2913l|FTSN_EC0LI CELL DIVISION PROTEIN FTSN

Contig9 from pir| |A47122 cell division protein FtsN - SΞQ ID n° 9036 PL-2525.1 3647710 to m 663

Escherichia coli gb|AAA23814.l| (L14281) cell

3648537 division protein [Escherichia coli] SΞQ ID n~2713

Sp]P06964|CYTR_ΞCOLI TRANSCRIPTIONAL REPRΞSSOR

CYTR pir| |RPΞCCT cyt transcription repressor cytr - Ξscherichia coli gb] AAB03066.1] (L19201)

CG Site No. 887 [Ξscherichia coli]

ContigS from emb | CAA27318.1 | (X03683) put. Cyt repressor (aa SEQ ID n° 9037 PL-2526.1 3648607 to m 783 1-341) [Escherichia coli] gb|AAC76916.l|

3649535 (AE000467) regulator for deo operon, udp, cdd, tsx, nupc, and nupG [Escherichia coli

K12] gb|AAG59129.l|AE005624_5 (AΞ005624) regulator for deo operon, udp, cdd, tsx, nupC, and nupG [Ξscherichia coli 0157:H7] SΞQ ID n-2714

Contig9 from gb|AAG59130.l|AE005624_6 (AE005624) primosomal SEQ ID n° 9038 PL-2527.1 3649962 to 76% protein N' (= factor Y) (putative helicase)

3652181 [Escherichia coli 0157 :H7] SEQ ID n~2715

sp|P02 32|RL31_ECOLI 50S RIBOSOMAL PROTEIN L31 pir| |R5EC31 ribosomal protein L31 [validated] -

Escherichia--coli gb|AAB03068.l| (L19201) 50S ribosomal protein L31 [Escherichia coli]

Contig9 from emb]CAA55286.l] (X78541) ribosomal protein L31

SEQ ID n° 9039 PL-4667.1 3652370 to 773

[Escherichia.. coli] gb|AAC76918. l| (AE000467) ... ^~ 3652585 50S ribosomal subunit protein L31 [Escherichia coli K12] gb|AAG59131.l|AE005624_7

(AE005624) 50S ribosomal subunit protein L31 [Escherichia coli 0157 :H7] #N/A sp|P06 03 |METJ_SALTY MET REPRESSOR (MET REGULON REGULATORY PROTEIN METJ) pir| |A23081 regulatory

Contig9 from protein metJ - Salmonella typhimurium SEQ ID n° 9040 PL-4669.1 3652713 to 91% emb|CAA25997.l| (X01961) etJ gène pot.

3653030 repressor (aa 1-104) [Salmonella typhimurium] #N/A sp|P00935|METB_ECOLI CYSTATHIONINE GAMMA- SYNTHASE (CGS) (O-SUCCINYLHOMOSERINE (THIOL) -LYASE) pir|| SYECCG O-succinylhomoserine (thiol) -lyase (EC 4.2.99.9) - Escherichia coli

Contig9 from gb|AAA24167.l| (K01547) cystathione gamma-

SΞQ ID n° 9041 PL-2528.1 3653306 to 84% synthase [Escherichia coli] gb| AAB03071.l|

3654478

(L19201) cystathionine gamma-synthase

[Escherichia coli] gb| AC76921. l| (AE000468) cystathionine gamma-synthase [Escherichia coli

K12] SEQ ID n~2716

sp | PO0562 | AK2H_ECOLI BIFUNCTIONAL

ASPARTOKINASE/HOMOSERINE DEHYDROGENASE II (AKII-

HDII) [INCLUDES..: _.ASPARTOKINASE II ;

HOMOSERINE DEHYDROGΞNASΞ II ]

Contig9 from pir] |DΞΞCK2 metL bifunctional enzyme -

SEQ ID n° 9042 PL-2529.1 3654481 to 863 Escherichia coli gb| AAB03072.l| (L1S201)

3656916 aspartokinase II/homoserine dehydrogenase II

[Escherichia coli] gb|AAC76S22.l|

(AEO00468) aspartokinase II and homoserine dehydrogenase II [Escherichia coli i2] SEQ ID n~2717

Contig9 from pir| |S03169 S , 10-methylenetetrahydrofolate

SEQ ID n° 9043 PL-2530.1 3657261 to p 873 reductase (FADH2) (EC 1.7.99.5) -

3658145 Salmonella typhimurium SEQ ID n~2719

ContigS from

SΞQ ID n° 9044 PL-6947.1 3658524 to No Hits found

3658856 #N/A

Contig9 from dbj |BAB06239.1 | (AP001515) transposase related

SEQ ID n° 9045 PL-6946.1 3658914 to 353 protein (20) [Bacillus halodurans]

3659069 #N/A

Contig9 from dbj |BAB06239.l| (AP001515) transposase related

SEQ ID n° 9046 PL-2531.2 3659604 to p 223 protein (20) [Bacillus halodurans]

3660563 SΞQ ID n~ 20

Contig9 from

SEQ ID n° 9047 PL-2533.1 3661575 to No Hits found

3662525 SEQ ID n~2722

Contig9 from

SEQ ID n° 9048 PL-4680.1 3662528 to No Hits found

3662923 #N/A

Contig9 from

SEQ ID n° 9049 PL-3225.1 3663217 to No Hits found

3663798 SEQ ID n~2478

Contig9 from

SΞQ ID n° 9050 PL-4682.1 3663915 to m No Hits found

3664019 #N/A

Sp | PO0864 | CAPP_ECOLI PHOS HOENOLPYRUVATE CARBOXYLASE (PEPCASE) (PEPC) pir| | QYEC phosphoenolpyruvate carboxylase (EC . l_.1.__3_l}_

Escherichia coli pdb|lFIY| Three-Dimensional

Structure Of Phosphoenolpyruvate Carboxylase

Contig9 from From Escherichia Coli At 2.8 A Resolution emb|CAA29332.l| (X05903) PEP carboxylase (AA 1-

SΞQ ID n° 9051 PL-2534.1 3664113 to m 84%

883) [Ξscherichia coli] gb|AAC4306 .l| (U00006)

3666749 phosphoenolpyruvate carboxylase [Escherichia coli] gb|AAC76938.l| (AE000469) phosphoenolpyruvate carboxylase [Escherichia coli K12] prf | |1005213A carboxylase,phosphoenolpyruvate [Ξscherichia coli] SEQ ID n~2723 sp ( P23S08 |ARGΞ_ΞCOLI ACΞTYLORNITHINE DEACΞTYLASΞ

(ACΞTYLORNITHINASΞ) (AO) (N-

ACETYLORNITHINASΞ) (NAO) pir| |B42377 acetylornithine deacetylase (ΞC 3.5.1.16) -

Ξscherichia coli emb|CAA44625.l| (X62807)

Contig9 from acetylornithine deacetylase subunit a2 SFQ ID n° 9052 PL-2535.1 3667032 to m 853

[Escherichia coli] emb |CAA33076. ι| (X55417) N-

3668189 acetylornithinase [Escherichia coli] gb|AAC43063.l| (U00006) acetylornithine deacetylase [Escherichia coli] gb| AAC76939.l|

(AΞ000470) acetylornithine deacetylase

[Ξscherichia coli K12] SEQ ID n~2724

s | P11446 | ARGC_ECOLI N-ACETYL-GAMMA-GLUTAMYL- PHOSPHATE REDUCTASE (AGPR) (N-ACETYL¬

GLUTAMATE SEMIALDEHYDE DEHYDROGENASE) (NAGSA DΞHYDROGΞNASE) pir| |RDECEP N-acetyl-gamma- glutamyl-phosphate reductase (EC 1.2.1.38) -

Contig9 from Escherichia coli gb|AAA23477.l| (M21446) argC SEQ ID n° 9053 PL-2536.1 3668292- to 823 (EC 1.2.1.38) [Ξscherichia coli] gb| AAC4306 .1 |

3669296 (U00006) N-acetyl-gamma-glutamyl-phosphate reductase [Ξscherichia coli] gb|AAC76940.l| (AE000470) N-acetyl-gamma- glutamylphosphate reductase [Escherichia coli K12] SEQ ID n~2725 sp|P11445|ARGB_EC0LI ACΞTYLGLUTAMATE KINASE (NAG

KINASE) (AGK) (N-ACETYL- -GLUTAMATE 5

PHOSPHOTRANSFERASE) pir| |KIECAE acetylglutamate kinase (EC 2.7.2.8) - Ξscherichia coli

Contig9 from gb]AAA23478.l| (M21446) argB (EC 2.7.2.8) SEQ ID n° 9054 PL-2537.1 3669322 to p 853 [Escherichia coli] gb| AAC43065.1 | (U00006)

3670095 acetylglutamate kinase [Escherichia coli] gb|AAC76941.l| (AE000470) acetylglutamate kinase

[Escherichia coli K12] gb |AAG59161.1 (AEO 056 7_5

(AE005627) acetylglutamate kinase [Escherichia coli 0157 :H7] SEQ ID n~2726 pir| |A82052 argininosuccinate synthase VC2642

Contig9 from

[imported] - Vibrio cholerae (group SEQ ID n° 9055 PL-2538.1 3670164 to p 81%

01 strain N16961) gb| AAF95783.1 | (AΞ004330)

3671378 argininosuccinate synthase [Vibrio cholerae] SEQ ID n-2727

Contig9 from gb|AAG59162.l|AΞ005627_6 (AE005627) SEQ ID n° 9056 PL-2539.1 3671531 to p 83% argininosuccinate lyase [Escherichia coli

3672910 0157 :H7] SEQ ID n~2728 sp|P71318[0XYR_ERWCA HYDROGEN PΞROXIDΞ-INDUCTBLΞ

Contig9 from

GΞNΞS ACTIVATOR gb | AAC72241.1 | (U74302) SEQ ID n° 9057 PL-2540.1 3673190 to p 84% oxidative stress transcriptional regulator

3674095

[Pectobacterium carotovorum] SEQ ID n-2.730

Contigs from sp|P27306|STHA_ECOLI SOLUBLE PYRIDINE NUCLEOTIDΞ SEQ ID n° 3058 PL-2541.1 3674087 to m 87% TRANSHYDROGΞNASE (STH) (NAD(P) (+) 3675484 TRANSHYDROGENASE [B-SPECIFIC] ) SΞQ ID n-2731

ContigS from gb|AAG59167.l]AE005628_3 (AE005628) orf, SΞQ ID n° 3059 PL-3227.1 3675859 to 91%

hypothetical protein [Escherichia coli 0157 :H7]

3676407 SEQ ID n~2479 sp|P27308|YIJD_ECOLI HYPOTHETICAL 13.0 KD

PROTEIN IN UDHA-TRMA INTERGENIC REGION (ORFB) pir| |G65203 yijD protein - Escherichia coli

Contig9 from (strain K-12) gb|AAC4307θ .l| (U00006) alternate ^"SΞQ ID n° 9060 PL-4686.1 3676524 to 69% name yijD [Escherichia coli] gb| AAC76946.l|

3676895 (AE000470) orf, hypothetical protein

[Escherichia coli K12] gb | AAG59168.1 | AE005628_4

(AEO05628) orf, hypothetical protein

[Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG5916S.l|AΞ005628_5 (AΞ005628) tRNA (uracil SEQ ID n° 9061 PL-2542.1 3676958 to m 79% 5-) -methyltransferase [Escherichia coli

3678058 0157 :H7] SΞQ ID n~2732 gb|AAG59170.l|AE005628_6 (AE005628) outer

Contig9 from membrane receptor for transport of vitamin B12, SEQ ID n° 9062 PL-2543.1 3678242 to 73%

E colicins, and bacteriophage BF23

3680101

[Escherichia coli 0157 :H7] SΞQ ID n~2733 gb|AAG53171.l|AΞ005628_7 (AE005628) glutamate

Contig9 from racemase, required for biosynthesis of SEQ ID n° 9063 PL-2544.1 3680046 to 773

D-glutamate and peptidoglycan [Ξscherichia coli

3680909

0157 :H7] SEQ ID n~2734 sp]P37417|MURB_SALTY UDP-N-

ACETYLENOLPYRUVOYLGLUCOSAMINΞ REDUCTASE (UDP-N-

ACΞTYLMURAMATΞ DΞHYDROGENASE) gb|AAA27163.l| (L14816) UDP-N-

ContigS from acetylenolpyruvoylglucosamine reductase SEQ ID n° 9064 PL-3060.1 3686724 to 76%

[Salmonella typhimurium]

3687749 gb|AAF33492.l| (AF170176) Salmonella typhimurium

UDP-N-acetylenolpyruvoylglucosamine reductase

(MURB) (SW.-P37417) [Salmonella typhimurium LT2] SEQ ID n~2296

Contig9 from gb|AAF33493.l| (AF170176) Salmonella typhimurium SEQ ID n° 9065 PL-3061.1 3687746 to 813 - bifunctional protein (BIRA)

3688705 (S.WLP3_7416) [Salmonella typhimurium LT2] SΞO ID n~2297 sp | Q9LSK3 | COAA_SALTY PANTOTHENATE KINASE (PANTOTHENIC ACID KINASE) gb | AAF33512.1 |

Contig9 from

(AF170176) 96% identity over 316 amino acids SEQ ID n° 9066 PL-3062-.1 3688749 to m 803 with E. coli pantothenate kinase

3689699

(SW:P15044) [Salmonella typhimurium

LT2] SEQ ID n~2298

Contig9 from SΞQ ID n° 9Ô^"67^~PL-4709.1 3690503 to No Hits found

3690682 #N/A sp|P21694|EFTU_SALTY ELONGATION FACTOR TU (EF- TU) pir| |S13561 translation elongation factor

ΞF-Tu.B - Salmonella typhimurium emb|CAA389l3.l| (X55117) elongation factor Tu

[Salmonella typhimurium] emb | CAA38912.11

Contig9 from

(X55116) elongation factor Tu [Salmonella

SEQ ID n° 9068 PL-3063.1 3690675 to 963 typhimurium] gb | AF33513.1 | (AF170176)

3691859

Salmonella typhimurium translation elongation factors TU (EF-TU) (SW:P216S4) ; contains similarity to PFam domain

PF0000S (GTP_BFTU, Score=541.8 E=4.6e-153, N=l

[Salmonella typhimurium LT2] SEQ ID n~229S

Contig9 from sp | 068934 | BFD_SERMA BACTERIOFERRITIN-ASSOCIATED SEQ ID n° 9069 PL-4710.1 3692613 to 633 FERREDOXIN gb | AAC14292.1 | (AF058451) YheAp

3692807 [Serratia marcescens] #N/A sp| 068935 |BFR_SERMA BACTERIOFERRITIN (BFR)

Contig9 from

(CYTOCHROME B-l) (CYTOCHROME B-557) SΞQ ID n° 9070 PL-3229.1 3692884 to 33% gb|AACl4293.l| (AF058451) bacterioferritin

3693360

[Serratia marcescens] SEQ ID n~2481 sp|P44378 |RS10_HAΞIN 3 OS RIBOSOMAL PROTEIN S10

Contig9 from pir| |D64092 ribosomal protein S10 - Haemophilus SEQ ID n° 9071 PL-4711.1 3693664 to 97% influenzae (strain Rd KW20) gb| AAC22435.1 |

3693975 (U32761) ribosomal protein S10 (rpSIO)

[Haemophilus influenzae Rd] #N/A

sp|P02386|RL3_ECOLI 50S RIBOSOMAL PROTEIN L3 pir] |R5EC3 ribosomal protein L3 [validated] -

Escherichia col. emb.|.CAA26 60.l| (X02613) ribosomal protein L3 (rplC) (aa 1-209)

[Ξscherichia coli] gb|AAA58117. l| (U18997) 50S

Contig9 from ribosomal subunit protein L3 [Escherichia coli]

SEQ ID n° 9072 PL-3064.1 369400^"8-to— 943 gb|AAC76345.l[ (AE000408) 50S ribosomal subunit 3694637 protein L3 [Ξscherichia coli K12] gb|AAG58441.l|AΞ005557_10 (AE005557) 50S ribosomal subunit protein L3 [Ξscherichia coli

0157 :H7] prf | |0509226A protein L3 [Ξscherichia coli] SEQ ID n~2300 sp|P11253 |RL4_YΞRPS 50S RIBOSOMAL PROTBIN L4

Contig9 from pir| |R5ΞB4Y ribosomal protein L4 - Yersinia SEQ ID n° 9073 PL-3065.1 3694654 to 923 pseudotuberculosis emb] CAA32543. l| (X14363)

3695259 ribosomal protein L4 (AA 1 - 201) [Yersinia pseudotuberculosis] SΞQ ID n~2301 sp|P02424|RL23_ECOLI 50S RIBOSOMAL PROTEIN L23 pir] |R5EC23 ribosomal protein L 3 [validated] -

Escherichia coli emb|CAA26 62.1 | (X02613) ribosomal protein L23 (rplW) (aa 1-100)

Contig9 from [Escherichia coli] gb| AAA58115.l| (U18997) 50S SEQ ID n° 9074 PL-4713.1 3695256 to 92% ribosomal subunit protein L23 [Escherichia coli]

3695558 gb]AAC76343.l| (AE000408) 50S ribosomal subunit protein L23 [Ξscherichia coli K12] gb|AAG58439.l|AΞ005557_8 (AE005557) 50S ribosomal subunit protein L23 [Escherichia coli

0157 :H7] #N/A

Contig9 from Sp|P49239 |RL2_YERΞN SOS RIBOSOMAL PROTEIN L2 SΞQ ID n° 9075 PL-3066.1 3635578 to 97% gb|AAC43513.l| (U11251) ribosomal protein L2

3696402 [Yersinia enterocolitica] SΞQ ID n~2302

sp|P02375|RS19_ECOLI 30S RIBOSOMAL PROTEIN S19 pir] |R3EC19 ribosomal protein SIS [validated] - Ξscherichia coli emb|CAA26 64.l| (X02613) ribosomal protein SIS (rpsS) (aa 1-273)

Contig9 from [Escherichia coli] gb) AAA58113.l|

SEQ ID n° 9076 PL-4714.1 3696417 to 97% (U18S97) 30S ribosomal subunit protein S19

3696695 [Escherichia coli] gb | AAC76341. l| (AEθ^"θÔ408)

3OS ribosomal subunit protein S19 [Escherichia coli K12] gb|AAG58437.l|AΞ005557_6

(AE005557) 30S ribosomal subunit protein S19

[Escherichia coli OT57:H7] #N/A sp[P02 23 |RL22_ECOLI 50S RIBOSOMAL PROTEIN L22 pir| ]R5EC22 ribosomal protein L22 [validated] -

Escherichia coli emb] CAA26465.l| (X02613) ribosomal protein L22 (rplV) (aa 1-110)

ContigS from [Escherichia coli] gb| AAA58112. l| (U18997) 50S SEQ ID n° 9077 PL-4715.1 36S6710 to 34% ribosomal subunit protein L22 [Ξscherichia coli]

3637042 gb|AAC76340.l[ (AΞ000408) 50S ribosomal subunit protein L22 [Ξscherichia coli K12] gb|AAG58436.l|AE005557_5 (AE005557) SOS ribosomal subunit protein L22 [Escherichia coli

0157:H7] #N/A sp|P02352|RS3_ΞCOLI 30S RIBOSOMAL PROTEIN S3 pir||R3EC3 ribosomal protein S3 [validated] -

Escherichia coli emb|CAA26466.l| (X02613)

Contig9 from ribosomal protein S3 (rpsC) (aa 1-233)

SEQ ID n° 9078 PL-3067.1 3697060 to 803

[Escherichia coli] gb|AAA58111.1 | (U18997) 30S

3637761 ribosomal subunit protein Ξ3 [Escherichia coli] gb|AAC76339.l| (AΞO00408) 3OS ribosomal subunit protein S3 [Escherichia coli K12] SEQ ID n~2303

sp|P02414]RL16_ΞCOLI 50S RIBOSOMAL PROTEIN L16 pir| |R5EC16 ribosomal protein L16 [validated] -

Ξscherichia coli emb|CAA26467. l| (X02613) ribosomal protein L16 (rplP) (aa 1-136)

ContigS from [Escherichia coli] gb |AAA58110. l| (U18997) 50S

SEQ ID n° S07S PL-4716.1 36S7774 to 943 ribosomal subunit protein L16 [Escherichia coli]

3698184 gb|AAC76338^". l| (AE000408) 50S ribosomal subunit protein L16 [Escherichia coli K12] gb|AAG58434.l|AE005557_3 (AΞ005557) 50S ribosomal subunit protein L16 [Escherichia coli

0157 :H7] ^{' "}#N/A sp|P02429| L29_ECOLI 50S RIBOSOMAL PROTEIN L2S pir| |R5EC29 ribosomal protein L29 [validated] - Ξscherichia coli emb|CAA26468.l| (X02613) ribosomal protein L29 (rpmC) (aa 1-63)

[Escherichia coli] gb | AAA58109.1 |

Contig9 from (U18997) 50S ribosomal subunit protein L29

SΞQ ID n° 9080 PL-4717.1 3698184 to [Escherichia coli] gb |AAC76337.1 | (AE000408)

3698375 50S ribosomal subunit protein L29 [Escherichia

COli K12] gb|AAG58433.l|AE005557_2

(AE005557) 50S ribosomal subunit protein L29

[Escherichia coli 0157 :H7] prf | |0612186A ribosomal protein L29 [Escherichia coli] #N/A

Sp|P02373 |RS17_ECOLI 30S RIBOSOMAL PROTEIN S17 pir] ]R3EC17 ribosomal protein S17 [validated] - Ξscherichia coli emb|CAA26469.l| (X02613) ribosomal protein S17 (rpsQ) (aa 1-84)

Contig9 from [Escherichia coli] gb |AAA58108.1 | SEQ ID n° 9081 PL-4718.1 3698375 to 91% (U18S37) 30S ribosomal subunit protein S17

3638623 [Escherichia coli] gb|AAC76336. l| (AE000408)

30S ribosomal subunit protein S17 [Escherichia coli K12] gb|AAG58432.l|AΞ005557_l

(AΞ005557) 30S ribosomal subunit protein S17

[Ξεcherichia coli 0157 :H7] #N/A

sp|P0241l|RL14_ΞCOLI 50S RIBOSOMAL PROTEIN L14 pir] |R5EC14 ribosomal protein

Escherichia coli emb | CAA2571

(rplN) (aa 1-123) [Ξsche

gb|AAA58107.l| (U18997) 50S ribosomal subunit

Contig9 from protein L14 [Escherichia coli] gbj AAC76335.l| -SEQ ID n° 9082 PL-4720.1 3698809 to p -93^"?

(AE000408) 50S ribosomal subunit protein L14

3699180

[Escherichia coli K12] gb|AAG58431.l|AΞ005556_24 (AE005556) 50S ribosomal subunit protein L14 [Ξscherichia coli

0157 :H7] prf | |θ806153A ribosomal protein L14

[Escherichia coli] #N/A sp|P024 5|RL24_ECOLI 50S RIBOSOMAL PROTΞIN L24 pir| |R5EC24 ribosomal protein L24 [validated] -

Escherichia coli emb| CAA25716.l| (X01563) L24

(rplX) (aa 1-104) [Escherichia coli]

Contig9 from gb]AAA58106.l] (U18997) 50S ribosomal subunit SΞQ ID n° 9083 PL-4721.1 3699191 to p 863 protein L2 [Ξscherichia coli] gb| AAC76334.l|

3699505 (AE000408) 50S ribosomal subunit protein L24

[Escherichia coli K12] gb|AAG58430.l[AE005556_23 (AE005556) 50S ribosomal subunit protein L24 [Escherichia coli

0157:H7] #N/A

Sp|P46178 |RL5_BUCAK 50S RIBOSOMAL PROTEIN L5

Contig9 from pir] | JC2278 ribosomal protein L5 - pea aphid SΞQ ID n° 9084 PL-3232.1 3699520 to 923 symbiont bacterium dbj |BAA06587. l| (D31786)

3700059 ribosomal protein L5 [Acyrthosiphon kondoi endosymbiont] SEQ ID n~2484

Contig9 from gb|AAK03486.l| (AE006177) RpS14 [Pasteurella SΞQ ID n° 9085 PL-4722.1 3700072 to 89% multocida]

3700377 #N/A

sp|P0236l|RS8_ECOLI 30S RIBOSOMAL PROTEIN S8 pir| |R3EC8 ribosomal protein S8 [validated] -

_Escherichia coli gb] AAA58103.l| (U18997) 30S ribosomal subunit protein S8 [Ξscherichia coli]

Contig9 from gb|AAC76331.l| (AE000408) 30S ribosomal subunit

SEQ ID n° 9086 PL-4724.1 3700411 to 943 3700803 protein S8, and regulator

[Escherichia coli K12] gb|AAG58427.l|AE005556_20 (AE005556) 30S ribosomal subunit protein S8, and regulator

[Escherichia coli 0157 :H7] #N/A sp|P02390|RL6_ΞCOLI 50S RIBOSOMAL PROTEIN L6 pirj |R5EC6 ribosomal protein L6 [validated] -

Escherichia coli gb[AAA58l02.l| (U18997) 50S

Contig9 from ribosomal subunit protein L6 [Escherichia coli] SEQ ID n° 9087 PL-3068.1 3700818 to 84% gb|AAC76330.l| (AE000408) 50S ribosomal subunit

3701351 protein L6 [Escherichia coli K12] gb|AAG58426.l|AE005556_19 (AE005556) 50S ribosomal subunit protein L6 [Escherichia coli

0157 :H7] SEQ ID n~2 sp| P02 19 |RL18_ECOLI 50S RIBOSOMAL PROTEIN L18 pir( [R5EC18 ribosomal protein L18 [validated] - Escherichia coli emb | CAA25721.1 | (X01563) L18

(rplR) (aa 1-117) [Escherichia coli]

Contig9 from gb|AAA58lθl.l| (U18997) 50S ribosomal subunit SEQ ID n° 9088 PL-4725.1 3701361 to 943 protein L18 [Escherichia coli] gb| AAC76329.l|

3701714 (AΞ000408) 50S ribosomal subunit protein L18

[Ξscherichia coli K12] gb|AAG58425.l|AE005556_18 (AE005556) 50S ribosomal subunit protein L18 [Ξscherichia coli

0157 : H7] #N/A

sp|P02356|RS5_ECOLI 30S RIBOSOMAL PROTEIN S5 pir| |R3EC5 ribosomal protein S5 [validated] - Ξscherichia coli _eπώ|_ÇAA25722.l| (X01563) S5

(rpSE) (aa 1-167) [Escherichia coli]

Contig9 from gb|AAA58100.l| (U18997) 30S ribosomal subunit

SEQ ID n° 9089 PL-3234.1 3701729 to 923 protein S5 [Ξscherichia coli] gb|AAC76328.ι|

3702229 (AE000408) 30S ribosomal subunit protein S5

[Ξscherichia coli K12] gb(AAG58424.l|AΞ005556_17 (AE005556) 30S ribosomal subunit protein S5 [Ξscherichia coli

0157 :H7] SEQ ID n~2485 sp|P46184|RL30_BUCAK 50S RIBOSOMAL PROTBIN L30 pir| |JC2284 ribosomal protein L30 - pea aphid

Contig9 from symbiont bacterium dbj |BAA03985.l| (D16555) SΞQ ID n° 3090 PL-4726.1 3702235 to 84% ribosomal protein L30 [Acyrthosiphon kondoi

3702414 endosymbiont] dbj |BAA06593.l| (D31786) ribosomal protein L30 [Acyrthosiphon kondoi endosymbion ] /A sp|P46185| L15_BUCAK 50S RIBOSOMAL PROTBIN L15 pir| |JC2272 ribosomal protein L15 - pea aphid

Contig9 from symbiont bacterium dbj |BAA03986.1 | (D16555) SΞQ ID n° 3031 PL-4727.1 3702418 to 933 ribosomal protein L15 [Acyrthosiphon kondoi

3702852 endosymbiont] dbj |BAA0659 . l| (D31786) ribosomal protein L15 [Acyrthosiphon kondoi endosymbiont] / sp|P03844|SECY_ECOLI PREPROTEIN TRANSLOCASE SECY

SUBUNIT pir| IQQECSY preprotein translocase secY

[validated] - Escherichia coli emb |CAA25725.l|

(X01563) SecY (PrlA) polypeptide (aa 1-443)

Contig9 from [Escherichia coli] gb | AAA58097.1 | (U18997) secY

SEQ ID n° 9092 PL-3069.1 3702860 to P 98% [Escherichia coli] gb|AAC76325.l| (AE000408)

3704191 putative ATPase subunit of translocase

[Escherichia coli K12] gb|AAG58421.l|AE005556_14 (AE005556) putative

ATPase subunit of translocase [Ξscherichia coli

0157 :H7] SEQ ID n~2305

Contig9 from gb|AAK03477.l| (AE006177) RpS13 [Pasteurella SΞQ ID n° 9093 PL-4730.1 3704490 to 91% multocida] _ 3704846 #N/A sp|P02356|RSll_ECOLI 30S RIBOSOMAL PROTEIN SU pir] [R3ΞC11 ribosomal protein SU [validated] -

Ξscherichia coli emb|CAA26393 ,l| (X02543) ribosomal protein SU (aa 1-129) [Ξscherichia

Contig9 from coli] gb|AAA58095.l] (U18997) 30S ribosomal

SEQ ID n° 9094 PL-4732.1 3704862 to 953 subunit protein SU [Ξscherichia coli]

3705251 gb|AAC76322.l| (AΞ000407) 30S ribosomal subunit protein SU [Escherichia coli K12] gb|AAG58418.l|AE005556_ll (AE005556) 30S ribosomal subunit protein SU [Ξscherichia coli

0157:H7] #N/A sp|P02354 |RS4_ECOLI 30S RIBOSOMAL PROTEIN S4 pir| |R3EC4 ribosomal protein S4 [validated] -

Escherichia coli emb|CAA26394.l| (X02543) ribosomal protein S4 (aa 1-206) [Escherichia

Contig9 from coli] gb|AAA58094.l| (U18997) 3OS ribosomal SΞQ ID n° 9095 PL-3070.1 3705289 to 85% subunit protein S4 [Ξscherichia coli]

3705909 gb|AAC76321.l| (AΞ000407) 30S ribosomal subunit protein S4 [Escherichia coli K12] gb|AAG58417.l|AE005556_10 (AE005556) 30S ribosomal subunit protein S4 [Escherichia coli

0157.- H7] SEQ ID n~2307

sp|P00574|RPOA_ECOLI DNA-DIRECTΞD RNA POLYMERASE ALPHA CHAIN (TRANSCRIPTASΞ ALPHA CHAIN) (RNA POLYMΞRASΞ ALPHA SUBUNIT) pir | |RNECA DNA- directed RNA polymerase (EC 2.7.7.6) alpha chain - Ξscherichia coli pir| |A41658 DNA-

directed RNA polymerase (ΞC 2.7.7.6) alpha chain - Salmonella typhimurium emb|CAA25337.l| (X00766) RNApolymerase alpha

ContigS from subunit [Escherichia coli] gb|AAA24577.l| SEQ ID n° 3036 PL-3071.1 3705935 to 97? (J01685) RNA polymerase alpha subunit

3706S24 [Escherichia coli] gb|AAA27214 ,l| (M77750) RNA^~ polymerase alpha-subunit [Salmonella typhimurium] gb| AA58092.l| (U18997) CG Site

No. 234 [Escherichia coli] gb |AAC76320. l|

(AE000407) RNA polymerase, alpha subunit

[Escherichia coli K12] gb|AAG58416.l|AE005556__9

(AEO05556) RNA polymerase, alpha subunit

[Ξscherichia coli 0157 :H7] SΞQ ID n~2308 sp|P02416|RL17_ECOLI 50S RIBOSOMAL PROTΞIN L17 pir| |R5EC17 ribosomal protein L17 [validated] -

Escherichia coli emb|CAA26396.l| (X02543) ribosomal protein L17 (aa 1-127) [Escherichia coli] emb|CAA25338.l| (X00766) ribosomal component L17 [Escherichia coli] gb|AAA24578. l|

Contig9 from (J01685) ribosomal protein L17 [Escherichia SEQ ID n° 9097 PL-4734.1 3706965 to P 86% coli] gb|AAA5809i.l| (U18997) 50S ribosomal

3707357 subunit protein L17 [Escherichia coli] gb|AAC76319.l| (AE000407) 50S ribosomal subunit protein L17 [Ξscherichia coli K12] gb|AAG58415.l|AE005556_8 (AE005556) 50S ribosomal subunit protein L17 [Ξscherichia coli

0157:H7] pr | | 0901236A protein L17 [Ξscherichia

sp|P36676|ZNTR_ECOLI ZN (II) -RESPONSIVE REGULATOR

OF ZNTA pir || 167892 hypothetical transcription regulator mscL-rplQ intergenic région -

Contig9 from Ξscherichia coli gb(AAA24773.1 ] (L29458) SΞQ ID n° 9098 PL-3236.1 3707492 to 73? similar to merR (Hg résistance) proteins

3707308 [Escherichia coli] gb|AAA58089.1 |

(U18997) yhdM [Escherichia coli] gb|AAC76317.1 |

(AE000407) putative transcriptional regulator

[Escherichia coli K12] SΞQ ID n~2487 sp]P36675|YHDL_ECOLI HYPOTHΞTICAL 8.1 KD PROTEIN

Contig9 from

IN MSCL-RPLQ INTERGENIC RΞGION pir] | 167891 yhdL SEQ ID n° 9099 PL-4735.1 3707988 to 613 protein - Escherichia coli gb|AAA24772. l|

3708188

(L29458) yhdL [Escherichia coli] #N/A sp|P23868 |TRKA_ΞCOLI TRK SYSTΞM POTASSIUM UPTAKE

PROTEIN TRKA pir] |S36252 potassium transport

System trkG/trkH protein trkA [validated] -

Escherichia coli emb |CAA36359. l| (X52114) TrkA protein of the constitutive K+ -transport

Contig9 from system Trk [Escherichia coli]

SEQ ID n° 9100 PL-3072.1 3708525 to 90% emb|CAA54371.l| (X77091) trkA [Ξscherichia coli]

3709901 gb|AAA58087.l] (U18997) TrkA protein of the constitutive K+ transport system Trk

[Ξscherichia coli] gb] AAC76315. l| (AE000407) transport of potassium [Ξscherichia coli K12] gb]AAG58411.l|AΞ005556_4 (AΞ005556) transport of potassium [Escherichia coli 0157 :H7] SEQ ID n~2309 sp|P36929|sUN_ECOLI SUN PROTΞIN (FMU PROTΞIN)

Contig9 from pir| |D65121 f u protein - Escherichia coli SEQ ID n° 9101 PL-3073.1 3709958 to 77% emb[CAA71359.l| (Y10307) sun [Escherichia coli]

3711247 gb|AAC76314.l| (AE000407) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~2310

s | P23882 | FMT_EC0LI METHIONYL-TRNA

FORMYLTRANSFΞRASΞ pir]]S23108 methionyl-tRNA formyltransferase (EC 2.1.2.9) - Escherichia_. coli emb|CAA45207.l| (X63666) methionyl-tRNA

Contig9 from formyltransferase [Ξscherichia coli]

SΞQ ID n° 9102 PL-3074.1 3711318 to m 82%

__ _.emb] CAA54368.11 (X77091) met ionyl-tRNAMetf. _

3712265 formyltransferase [Ξscherichia coli] gb|AAC76313.l| (AE000407) 10- formyltetrahydrofolate:L-methionyl-tRNA(fMet)

N-formyltransferase [Escherichia coli K12] SEQ ID n~2311 sp|P2725l|DEF_ΞCOLI POLYPΞPTIDE DEFORMYLASE

(PDF) (FORMYLMETHIONINE DΞFORMYLASE) pir( |S23107 N-formylmethionylaminoacyl-tRNA deformylase (EC 3.5.1.27) -

Escherichia coli emb| CAA45206.1 | (X63666) fms

[Ξscherichia coli] emb] CAA54367.1 ] (X77091)

ContigS from peptide deformylase [Ξscherichia coli]

SEQ ID n° 9103 PL-3237.1 3712290 to m 92? emb|CAA54826.l| (X77800) deformylase 3712802

[Escherichia coli] gb| AAA58084.l| (U18997) N- formylmethionylaminoacyl-tRNA deformylase

[Escherichia coli] gb|AAC76312. l|

(AE000407) peptide deformylase [Escherichia coli

K12] gb|AAG58408.l|AΞ005556_l (AΞ005556) peptide deformylase [Escherichia coli 0157 :H7] SEQ ID n~2488

ContigS from gb|AAG58407.l|AE005555_7 (AE005555) smf gène

SEQ ID n° 9104 PL-3075.1 3712S36 to 59% product [Escherichia coli 0157 :H7]

3714021 SΞQ ID n~2312

Contig9 from gb|AAG58405.l[AΞ005555_5 (AΞ005555) putative DNA

SEQ ID n° 9105 PL-3076.1 3714095 to 66% topoisomerase [Escherichia coli 0157 :H7]

3714625 SΞQ ID n~2313

Contig9 from gb|AAG58404.l|AE005555_4 (AΞ005555) orf,

SEQ ID n° 9106 PL-3238.1 3714639 to 753 hypothetical protein [Ξscherichia coli 0157 :H7]

3715208 SΞQ ID n~2489

sp | P15770 | AR0E_EC0LI SHIKIMATE 5 -DEHYDROGENASE

C SEQ ID n° 9107 PL-3077.1

(AΞ000406) dehydroshikimate reductase

[Escherichia coli K12] SEQ ID n~2314 sp|P45795|YRDB_ECOLI HYPOTHETICAL 10.0 KD

PROTEIN IN RRND-AROΞ INTERGENIC RΞGION (F85) pir| |C65120 hypothetical 10.0 kD protein in rrnd

Contig9 from aroe intergenic région - Ξscherichia

SEQ ID n° 9108 PL-4738.1 3716036 to 55% coli (strain K-12) gb|AAA58077.lJ (U18997)

3716299

ORF_f85 [Fscherichia coli] gb|AAC76305.1]

(AΞ000406) orf, hypothetical protein

[Escherichia coli K12] #N/A

ContigS from gb|AAG58401.l|AE005555_l (AE005555) putative SEQ ID n° 9109 PL-3239.1 3716275 to m 823 transferase [Ξscherichia coli 0157 :H7]

3716820 SEQ ID n~2490 gb|AAF33488.l| (AF233324) 83% identity with Ξ. coli hypothetical protein (YIFA)

Contig9 from

(SP:P22788) and 95% identity with amino acids 1- SEQ ID n° 9110 PL-3184.1 3723408 to 733

80 of Ξ. coli possible regulatory

3724244 protein (PSSR) (SP:P27826)

[Salmonella typhimurium LT2] SΞQ ID n~2433

Sp|P27827|YIFΞ_ECOLI PROTEIN YIFE pir||G65179 hypothetical 13.1 kD protein in pssR-ilvL

ContigS from intergenic région - Escherichia coli

SEQ ID n° 9111 PL-4762.1 3724370 to 73% (strain K-12) gb |AAC77485.1 | (AE000453) orf,

3724708 hypothetical protein [Escherichia coli K12] gb|AAG58960.l|AΞ005608_l (AΞ005608) orf, hypothetical protein [Escherichia coli 0157 :H7] #N/A pir| |S30663 hypothetical protein f516 -

Contig9 from

Ξscherichia coli gb | AAA67569. l| (M87049) SEQ ID n° 9112 PL-3185.1 3724755 to 773 similar to Mg chelatase subunit of Rhodobacter

3726278 capsulata [Escherichia coli] SEQ ID n~2434

Contig9 from

SEQ ID n° 9113 PL-4763.1 3727267 to No Hits found

3727350 #N/A

SΞQ ID n° 9114 PL-1954.2

SΞQ ID n° 9115 PL-4764.1 3728944 to 68% coli acetolactate synthase ) ILVM)

3729201 (SP:P13048) [Salmonella typhimurium LT2] #N/A pdb|lA3G|A Chain A, Branched-Chain Amino Acid

Aminotransferase From Escherichia

Contig9 from Coli pdb|lA3G|B Chain B, Branched-Chain Amino SΞQ ID n° 9116 PL-1955.1 3729225 to 923 Acid Aminotransferase From

3730151 Bscherichia Coli pdb|lA3G|C Chain C, Branched- Chain Amino Acid Aminotransferase From Escherichia Coli SΞQ ID n~2087 Sp|P0579l|lLVD_ECOLI DIHYDROXY-ACID DEHYDRATASE

(DAD) pir| |DWECDA dihydroxy-acid dehydratase

Contig9 from (ΞC 4.2.1.9) - Ξscherichia coli gb | AAB59053.1 | SEQ ID n° 9117 PL-1956.1 3730344 to 843 (M10313) dihydroxyacid dehydrase [Ξscherichia

3732194 coli] emb|CAA28576.l| (X04890) dihydroxy acid

[Escherichia coli] prf | | 1312306A gène ilvGMΞDA cluster [Escherichia coli] SΞQ ID n-2088 gb|AAF33473.l| (AF233324) S. typhimurium threonine deaminase (ILVA) (SP:P20506) ;

Contig9 from contains similarity to Pfam families PF00291

SEQ ID n° 9118 PL-1957.2 3732199 to 893 (Pyridoxal-phosphate dépendent enzyme,

3733599 score=467.9, E=8.4e-137, N=l) and

PF00585 (C-terminal domain of

Threonine dehydratase, score=329.2, E=> #N/A

sp|P27304|EMRB_ECOLI MULTIDRUG RESISTANCE

PROTEIN B pir| |G65048 multidrug résistance proteinJ.-: Bscherichia coli gb| AAC75733.l|

Contig9 from (AΞ000353) multidrug résistance; probably SΞQ ID n° 9119 PL-1958.1 3733939 to m 783 membrane translocase [Escherichia

3735456 coli Ki2]_ dbj |BAA16548.1| (D90891) multidrug résistant protein emrB [Escherichia coli] dbj |BAA16553.l| (D90892) multidrug résistant protein emrB [Ξscherichia coli] SEQ ID n~2090 pir| | JC1344 multidrug résistant protein emrA - Contig9 from

Escherichia coli gb|AAA23724.l| (M86657)

SEQ ID n° 9120 PL-1959.1 3735464 to m 72% multidrug résistance; putative [Escherichia

3736636 coli] SEQ ID n~2091

Contig9 from dbj |BAB20935.2| (D85817) ORF [Staphylococcus SEQ ID n° 9121 PL-1S60.1 3736S53 to m 57% aureus]

3737702 SEQ ID n-2093 pir| |A70613 hypothetical protein Rv0636 -

ContigS from

Mycobacterium tuberculosis (strain SEQ ID n° 9122 PL-1961.1 3737759 to m 15%

H37RV) emb|CAB07125.l] (Z92772) hypothetical

3738574 protein Rv0636 [Mycobacterium tuberculosis] SEQ ID n~2094 pir| |B70448 3 -oxoacyl- [acyl-carrier-protein]

Contig9 from synthase (EC 2.3.1.41) II - Aquifex SΞQ ID n° 9123 PL-1962.1 3738571 to m 553 aeolicus gb|AAC07574.l| (AE000752) 3 -oxoacyl-

3739836 [acyl-carrier-protein] synthase II [Aguifex aeolicus] SEQ ID n~2095 pir| ]B81052 acyl carrier protein NMB1696

Contig9 from [imported] - Neisseria meningitidis SΞQ ID n° 9124 PL-4767.1 3739992 to m 463 (group B Strain MD58) gb|AAF42044.l| (AEÛ02520)

3740228 acyl carrier protein [Neisseria meningitidis

MC58] #N/A

Contig9 from gb|AAG01802.l|AF276772_l (AF276772) cysteine SΞQ ID n° 9125 PL-1963.1 3740261 to 54% desulfurase NifS [Methanosarcina thermophila]

3741451 SΞQ ID n~î096 Contig9 from gb|AAG20546.l| (AE005125) nitrogen fixation SΞQ ID n° 9126 PL-4768.1 3741448 to m 493 protein; NifU [Halobacterium sp. NRC-

pir] |S15161 long-chain-fatty-acid--luciferin-

Contig9 from component ligase (EC 6.2.1.19) luxE - SΞQ ID n° 9127 PL-1964.1 3741821 to _ 393 Photobacterium phosphoreum emb | CAA39107.1 |

3742999 (X55459) fatty acyl-protein synthetase

[Photobacterium phosphoreum] SEQ ID n~1097

pir| |E69725 potassium uptake trkA - Bacillus

Contig9 from subtilis gb|AAB80908.l| ^"(U93876) hypothetical SΞQ ID n° 9128 PL-1965.1 3743393 to p 48% protein YrdP [Bacillus subtilis]

3744478 emb|CAB14605.l| (Z99117) alternate gène name: yrdP [Bacillus subtilis] SEQ ID n~2098 sp|Q51872|LUMQ_PHÔLB ^"PROBABLB TRANSCRIPTIONAL

RBGULATOR LUMQ pir| | JC4504 porin

Contig9 from thermoregulatory protein ΞnvY homolog - SΞQ ID n° 9129 PL-1966.1 3744859 to m 33%

Photobacterium leiognathi

3745713 gb|AAA87846.l| (U35231) lu Q gène product

[Photobacterium leiognathi] SEQ ID n~2099

Contig9 from gb|AAG58968.l|AE005608_9 (AE005608) positive SΞQ ID n° 9130 PL-1967.1 3746294 to m 77% regulator for ilvC [Escherichia coli 0157:H7]

3747175 SEQ ID n~£100 Contig9 from gb|AAG58969.l|AE005609_l (AE005609) ketol-acid SΞQ ID n° 9131 PL-1968.1 3747365 to p 90% reductoisomerase [Escherichia coli 0157 :H7]

3748843 SEQ ID n~2101 ContigS from gb|AAG58972.l|AE005609_4 (AΞ005609) rep SΞQ ID n° 9132 PL-1969.1 3749053 to p 88% helicase, a single-stranded DNA dépendent ATPase

3751080 [Ξscherichia coli 0157 :H7] SΞQ ID n~2102 Contig9 from gb|AAG58973.l|AΞ005609_5 (AE005609) guanosine SΞQ ID n° 9133 PL-1970.1 3751131 to m 80% pentaphosphatase ; exopolyphosphatase

3752633 [Ξscherichia coli 0157:H7] SEQ ID n~2104 sp|P24229|RHLB_BCOLI PUTATIVE ATP-DEPENDENT RNA

Contig9 from HELICASE RHLB pir] |G65181 rhlB protein - SEQ ID n° 9134 PL-1971.1 3752639 to m 88% Escherichia coli (strain κ-12) gb| AAC76785.l|

3753925 (AE000454) putative ATP-dependent RNA helicase

[Escherichia coli K12] SEQ ID n~2105

gb|AAA67270.l| (U16857) Derived from E. coli

Contig9 from thioredoxin gène; normal translation SΞQ ID n° 9135 PL-4771.1 3754044 to 88% termination codon following nucleotide 3050 has 3754370 been removed [Cloning vector pTRXFUS] #N/A sp|P03002|RHO_ECOLI TRANSCRIPTION TERMINATION

FACTOR RHO pir| | TWΞCR transcription termination factor rho - Escherichia coli gb|AAA24532.l|

Contig9 from (J01673) transcription termination factor SEQ ID n° 9136 PL-1972.1 3754847 to 983 [Escherichia coli] gb|AAA67583.1] (M87049)

3756106 transcription termination factor rho

[Escherichia coli] gb|AAC76788.1 | ^" (AE000454) transcription termination factor Rho,- polarity suppressor [Ξscherichia coli K12] SEQ ID n~£106 gb]AAG58979.l|AΞ005610_3 (AΞ005610) UDP-

Contig9 from GlcNAc :undecaprenylphosphate GlcNAc-1-phosphate SEQ ID n° 9137 PL-1973.1 3756527 to 83% transferase; synthesis of enterobacterial common

3757612 antigen (ΞCA) [Escherichia coli

0157:H7] SEQ ID n~il07 sp | P25905 | WZZΞ_JECOLI LIPOPOLYSACCHARIDE

BIOSYNTHESIS PROTEIN WZZE pir| |D65182 hypothetical 39.5K protein (rfe 5' région) -

Contig9 from

Ξscherichia coli gb|AAC76790.1 | (AΞ000454) SEQ ID n° 9138 PL-1974.1 3757642 to 723 putative transport protein [Escherichia coli

3758697

K12] gb|AAG58980.l|AE005610_4 (AE005610) putative transport protein [Escherichia coli

0157:H7] SEQ ID n~2108 gb|AAG58981.l|AΞ005610_5 (AΞ005610) UDP-N-acetyl

Contig9 from glucosamine -2 -epimerase; synthesis of SEQ ID n° 9139 PL-1975.1 3758794 to 85% enterobacterial common antigen (ECA)

3759945

[Escherichia coli 0157 :H7] SEQ ID n-2.109 pir| |B49350 hypothetical protein 379 (nfrC 3' région) - Escherichia coli

ContigS from gb|AAG58982.l|AΞ005610_6 (AΞ005610) UDP-N-acetyl- SΞQ ID n° 9140 PL-1S76.1 3759950 to 86%

D-mannosaminuronic acid dehydrogenase;

3761227 synthesis of enterobacterial common antigen

(ΞCA) [Ξscherichia coli 0157 :H7] SEQ ID n~2110

sp|P27830|RFFG_ΞCOLI DTDP-GLUCOSE 4,6-

DEHYDRATASE pir[[G65182 dTDPglucose 4,6-

SEQ ID n° 9141 PL-1977.1

(DTDP-GLUCOSE PYROPHOSPHORYLASE) pir[|H65182

Contig9 from glucose-1-phosphate thymidylyltransferase (EC SEQ ID n° 9142 PL-1978.1 3762316 to p 883

2.7.7.24) - Escherichia coli

3763197 gb|AAC76794.l| (AE000455) glucose-1-phosphate thymidylyltransferase [Escherichia coli K12] SEQ ID n~2112

Contig9 from SEQ ID n° 9143 PL-1979.1

gb|AAF33462.l| (AF233324) 92% identity with E. coli lipopolysaccharide biosynthesis

Contig9 from protein (WΞCΞ) (SP:P27833) ,- contains SEQ ID n° 9144 PL-1980.1 3763896 to p 803 similarity to Pfam family PF01041

3765026 (DegT/DnrJ/ΞryCl/StrS family) , εcore=295.0, Ξ=S.2e-85, N=l [Salmonella typhimurium LT2] SEQ ID n~2115 gb|AAF33461.l| (AF233324) 8S% identity with E.

Contig9 from coli lipopolysaccharide biosynthesis SEQ ID n° 9145 PL-1981.1 3765028 to p 843 protein (WZXE) (SP:P2783) [Salmonella

3766278 typhimurium LT2] SEQ ID n~2116

Contig9 from sp|P56258|YIFM_ECOLI HYPOTHETICAL 40.6 KDA SΞQ ID n° 9146 PL-1982.1 3766275 to p 753 PROTEIN IN WZXE-WΞCF INTERGENIC REGION

3767360 SΞQ ID n~2117

gb|AAG58989.l|AΞ005610_13 (AE005610) TDP-

Contig9 from

Fuc4NAc:lipidII transferase; synthesis of

SΞQ ID n° 3147 PL- 1983.1 3767357 to 823 enterobacterial common antigen_. (ΞCA)

3768736

[Ξscherichia coli 0157 :H7] SΞQ ID n~ïll8 sp|P37457[WΞCG_SALTY PROBABLE UDP-N-ACETYL-D-

MANNOSAMINURONIC ACID TRANSFERASE

(UDP-MANNACA TRANSFERASE) pir| |S27727 hypothetical protein - Salmonella typhimurium

Contig9 from gb|AAAS2025.l| (MS5047) rffM gène product SEQ ID n° 9148 PL-1984.1 3768727 to 833

[Salmonella typhimurium] gb|AAF33458.l|

3769464

(AF233324) S. typhimurium putative UDP-N-acetyl-

D-mannosamine transferase (WECG)

(SP:]P37457) [Salmonella typhimurium

LT2] SEQ ID n~211S sp|P37456|YIFK_SALTY PROBABLΞ TRANSPORT PROTEIN

Contig9 from

YIFK pir||S27728 probable transport protein -

SEQ ID n° 9149 PL-1985.1 3769708 to 81%

Salmonella typhimurium gb (AAAS2026.1 | (M95047)

3771099 transport protein [Salmonella typhimurium] SEQ ID n~2120

Contig9 from

SΞQ ID n° 9150 PL-4776.1 3771506 to m No Hits found

3771607 #N/A

ContigS from gb|AAG00942.l|AF272977_2 (AF272977) transposase

SEQ ID n° 9151 PL-1986.1 3772820 to 293 [Mycoplasma hyopneumoniae]

3774436 SEQ ID n~2121

ContigS from pir||S75993 hypothetical protein - Synechocystis

SΞQ ID n° 9152 PL-4778.1 3774504 to 503 sp. (strain PCC 6803) dbj |BAA10840.l| (D64006)

3774677 hypothetical protein [Synechocystis sp.] #N/A sp|P09128|HEMY_ECOLI HEMY PROTEIN pir||S01694 hemY protein - Escherichia coli emb |CAA31135. l|

(X12614) ORF Y (AA 1 - 398) [Escherichia coli]

ContigS from gb|AAA67598.l| (M87049) hemY [Escherichia coli] SΞQ ID n° 3153 PL-1387.1 3774743 to m 783 gb|AAC76805.l| (AΞ000456) a late step of

3775981 protoheme IX synthesis [Escherichia coli

K12] gb|AAG58994.l|AE005611_4 (AE005611) a late step of protoheme IX synthesis [Escherichia coli

0157:H7] SEQ ID n~2122

ContigS from gb|AAG58995.l|AE005611_5 (AE005611) SEQ ID n° 3154 PL-1388.1 3775S85 to 763 uroporphyrinogen III methylase [Ξscherichia coli

377710S 0157 :H7] SEQ ID n~2123 ContigS from gb(AAG58996.l|AE005611_6 (AΞ005611) SEQ ID n° 9155 PL-1989.1 3777130 to 663 uroporphyrinogen III synthase [Ξscherichia coli

3777870 0157.-H7] SEQ ID n~ïl24 sp|Q59684|HEM3_PROMI PORPHOBILINOGEN DΞAMINASΞ

Contig9 from (PBG) (HYDROXYMETHYLBILANE SYNTHASE) SEQ ID n° 9156 PL-1990.1 3777867 to m 86% (HMBS) (PRE-UROPORPHYRINOGEN SYNTHASE)

3778808 gb|AAC44329.l| (U22969) porphobilinogen deaminase [Proteus mirabilis] SEQ ID n~2126 sp]Q59685|CYAA_PROMI ADENYLATE CYCLASE (ATP

Contig9 from

PYROPHOSPHATΞ-LYASE) (ADENYLYL CYCLASE) SEQ ID n° 9157 PL-1991.1 3779407 to p 85% gb|AAC44330.l] (U22969) adenylate cyclase

3781977

[Proteus mirabilis] SΞQ ID n~2127 sp|P401 8 |CYAY_ERWCH CYAY PROTEIN pir||S23700

Contig9 from cyaY protein - Erwinia chrysanthemi SEQ ID n° 9158 PL-4779.1 3782006 to m 81% emb|CAA44892.l| (X63207) cyaY [Erwinia

3782326 chrysanthemi] #N/A sp|P33166]YIFL_EC0LI HYPOTHETICAL 7.2 KD PROTEIN

Contig9 from

IN CYAY-DAPF INTERGENIC REGION SEQ ID n° 9159 PL-4780.1 3782405 to p 47% gb|AAG59001.l|AE005612_4 (AE005612) Z5325 g ne

3782590 product [Escherichia coli 0157 :H7] #N/A pir||S0l313 diaminopimelate epimerase (ΞC

5.1.1.7) - Ξscherichia coli (strain

Contig9 from K-12) gb|AAC76812.l| (AE000457) diaminopimelate SEQ ID n° 9160 PL-1992.1 3782639 to p 863 epimerase [Escherichia coli K12]

3783463 gb|AAG59002. diaminopimelate

Contig9 from gb|AAF33444.l| (AF233324) 86% identity with E. SEQ ID n° 9161 PL-1993.1 3783496 to p 693 coli hypothetical protein (YIGA)

3784200 (SP:P23305) [Salmonella typhimurium LT2] SΞQ ID n~îl29 Contig9 from gb|AAC46276.l| (AF028736) site spécifie SEQ ID n° 9162 PL-1994.1 3784197 to p 833 recombinase [Serratia marcescens]

3785108 SEQ ID n~2130

Contig9 from gb|AAC46277.l| (AF028736) No définition line SEQ ID n° 9163 PL-1995.1 3785108 to p 68% found [Serratia marcescens]

3785824 SEQ ID n~£131 gb|AAF33441.l| (AF233324) 98% identity with E.

Contig9 from coli DNA helicase (UVRD) (SP:P03018) ,-

SEQ ID n° 9164 PL-1996.1 3785891 to p 91% contains similarity to Pfam family PF00580

3788053 (UvrD/REP helicase)^", score=8l2.9, E=l.2e-240,

N=l [Salmonella typhimurium LT2] SEQ ID n~2132 sp]P31138|CORA_SALTY MAGNESIUM AND COBALT

TRANSPORT PROTEIN CORA pir| ]A47157 magnésium transport protein CorA - Salmonella typhimurium

Contig9 from gb|AAA02966.l| (L11043) Mg2+ transport protein SEQ ID n° 9165 PL-1997.1 3788149 to p 923

[Salmonella typhimurium] gb| AAF33440. l|

3789099

(AF233324) s. typhimurium magnésium transport protein (CORA) (SP:P31138)

[Salmonella typhimurium LT2] SEQ ID n~2133

Contig9 from SΞQ ID n° 9166 PL-4782.1 3789665 to m No Hits found

3789814 #N/A Contig9 from SΞQ ID n° 9167 PL-4783.1 3789865 to m No Hits found

3790245 #N/A gb|AAF33437.l| (AF233324) 90% identity with E. coli rarD gène product (RARD)

Contig9 from

(SP:P27844) ; contains similarity to pfam family SΞQ ID n° 9168 PL-1998.1 3790253 to m 783

PF00892 (Intégral membrane protein) ,

3791143 score=17.4, E=0.05, N=l [Salmonella typhimurium LT2] SEQ ID n-2134

Contig9 from sp|P27845|YIGI_ECOLI HYPOTHETICAL 17.1 KD SΞQ ID n° 9169 PL-3241.1 3791255 to m 793 PROTEIN IN RARD-PLDA INTERGΞNIC REGION

3791725 SEQ ID n~2493 pir| |T44595 alcaligin synthesis protein alcC

Contig9 from

[validated] - Bordetella SΞQ ID n° 9170 PL-1999.1 3792021 to m 51% bronchiseptica gb|AAB40620.1 j (U61153) AlcC

3794438

[Bordetella bronchiseptica] SEQ ID n~2135

Contig9 from emb|CAB87220.l| (AL163641) putative SEQ ID n° 9171 PL-2000.1 3794438 to m 68% onooxigenase [Streptomyces coelicolor A3 (2)] 3795739 SEQ ID n~2139

Contig9 from emb|CAB8721S . l| (AL163641) putative pyridoxal- SEQ ID n° 9172 PL-2001.1 3795770 to 63% dependent decarboxylase [Streptomyces

3797314 _ coelicolor A3 (2) ] SΞQ ID n~2140 sp|P39405|FHUF_ECOLI FERRIC IRON REDUCTASE

PROTEIN FHUF pir||S56534 ferrichrome-iron

Contig9 from reductase (EC 1.6.99.-) fhuF [validated] - SEQ ID n° 9173 PL-2002.1 3797673 to m 46% Escherichia coli gb| AAA97266.1 | (U14003)

3798452 ORF_f262b [Escherichia coli] gb| AC77323.1 |

(AE000507) orf, hypothetical protein

[Ξscherichia coli K12] SEQ ID n~2141 pir| |T36888 probable iron-siderophore uptake

System ATP-binding component -

Contig9 from

Streptomyces coelicolor emb|CAB52849.l| SEQ ID n° 9174 PL-2003.1 3798627 to m 683

(AL109848) putative iron-siderophore uptake

3799439 system ATP-binding component

[Streptomyces coelicolor A3 (2)] SEQ ID n~2142 pir| |C82281 ferrie vibriobactin ABC transporter, permease protein VC0778 [imported] -

Contig9 from Vibrio cholerae (group 01 strain N16961) SEQ ID n° 9175 PL-2004.1 3799424 to m 50% gb|AAD48882.l| (U52150) cytoplasmic membrane

3800530 permease [Vibrio cholerae] gb|AAF93943.l|

(AEO 04163) ferrie vibriobactin ABC transporter, permease protein [vibrio cholerae] SEQ ID n~£143 pir] |T36890 probable iron-siderophore uptake

System transmembrane component -

Contig9 from

Streptomyces coelicolor emb| CAB52851. l| SEQ ID n° 9176 PL-2005.1 3800469 to m 62?

(AL109848) putative iron-siderophore uptake

3801482 system transmembrane component

[Streptomyces coelicolor A3 (2) ] SEQ ID n~2144

ContigS from gb|AAB97475.l| (U02617) DtxR/iron regulated SΞQ ID n° 3177 PL-2006.1 3801473 to m 46% lipoprotein precursor [Corynebacterium

3802435 diphtheriae] SEQ ID n-2145

Contig9 from gb|AAD26430.l|AF135154_l (AF135154) ferrie SEQ ID n° 9178 PL-2007.1 3802564 to m 55% alcaligin siderophore receptor [Bordetella

_ ^1804807 pertussis] SEQ ID n~1146 pir| |T44595 alcaligin synthesis protein alcC

Contig9 from

[validated] - Bordetella

SEQ ID n° 917S PL-2008.1 3804858 to m 64% bronchiseptica gb|AAB40620. l| (U61153) AlcC 3806681 [Bordetella bronchiseptica] SEQ ID n~2147

ContigS from gb|AAG59018.l|AE005613_ll (AE005613) ATP- SΞQ ID n° 9180 PL-2009.1 3807130 to p 84% dependent DNA helicase [Escherichia coli

3808956 0157 :H7] SEQ ID n~2148 Contig9 from emb]CAÂ26932.l| (X03155) lysophospholipase L2 SEQ ID n° 9181 PL-2010.1 3808971 to p 66% (aa 1-340) [Escherichia coli] prf | ] 1111247A

3809969 lysophospholipase L2 [Escherichia coli] SEQ ID n~2150 Contig9 from gb|AAG59022.l|AE005614_2 (AΞ005614) Z5347 gène SEQ ID n° 9182 PL-2011.1 3809992 to p 71% product [Escherichia coli 0157 :H7]

3810792 SΞQ ID n~2151 dbj |BAB03895.l| (AP001507) transposase (09)

[Bacillus halodurans] dbj |BAB03988. l|

(AP001507) transposase (09) [Bacillus halodurans] dbj |BAB05361.1 | (AP001512) transposase (09) [Bacillus halodurans] dbj |BAB05614.l| (AP001513) transposase (09)

Contig9 from

[Bacillus halodurans] dbj |BAB06561.l| SEQ ID n° 9183 PL-3242.1 3810993 to p 743

(AP001516) transposase (09) [Bacillus

3811448 halodurans] dbj |BAB06952.l| (AP001518) transposase (09) [Bacillus halodurans] dbj |BAB07185.l| (AP001518) transposase (09)

[Bacillus halodurans] dbj |BAB07197. l|

(AP001518) transposase (09) [Bacillus halodurans] SEQ ID n~2494

sp|P03829|lSA2_SHIDY INSΞRTION ELEMENT ISO-ISIN

PROTEIN INSA pir | | IEΞBB9 insA protein -

Shigella dysenteriae insertion séquence IS1-N

Contig9 from gb|AAA25031.l| (J01737) insa (putative); SEQ ID n° 9184 PL-4788.1 3811641 to m 683 putative [unidentified insertion

3811943 séquence] gb|AAF28118. l|AF153317_14 (AF153317)

InsA [Shigella dysenteriae] gb|AAF28138.l|AF153317_35 (AF153317) InsA

[Shigella dysenteriae] #N/A

ContigS from

SEQ ID n° 9185 PL-2012.1 3812121 to m ^" No Hits found

3813614 SΞQ ID n~2152

ContigS from

SEQ ID n° 9186 PL-3243.1 3813657 to m No Hits found

3814106 SEQ ID n~2495

Contig9 from

SEQ ID n° 9187 PL-4790.1 3814239 to No Hits found

3814313 #N/A ref ]NP_046004.l| ORF H0646 [Halobacterium sp.

NRC-l] ref |NP_046095.l| ORF H170S

[Halobacterium sp. NRC-l] pir||T08276 probable transposase H0646 - Halobacterium sp. (strain

NRC-l) insertion séquence ISH8 plasmid pNRClOO gb]AAC82843.l| (AF016485) ORF

H0646 [Halobacterium sp . NRC-l] gb | AAC82934.1 |

Contig9 from (AF016485) ORF H1709 [Halobacterium sp. NRC-l]

SEQ ID n° 9188 PL-2013.1 3814494 to 31% gb|AAG18697.l| (AE004975) Vng0059h

3815435 [Halobacterium sp. NRC-l] gb|AAGl89lθ.l|

(AΞ004993) Vng0337h [Halobacterium sp. NRC-l] gb|AAG20310.l| (AE005105) Vng2175h

[Halobacterium sp. NRC-l] gb| AAG20766.l|

(AE005145) Vng6079h [Halobacterium sp. NRC-l] gb|AAG20820.l| (AE005150) Vng6147h

[Halobacterium sp. NRC-l] gb| AAG2104 .l|

(AE005169) Vng6447h [Halobacterium s . NRC-l] SEQ ID n~2153

gb|AAG13907.l| (AE005074) Vngl653h

[Halobacterium sp. NRC-l] gb| AG20788.l|

Contig9 from

(AΞ005147) Vng6106h [Halobacterium sp. NRC-l] SEQ ID n° 9189 PL-3-244.1 3815507 to 353 gb|AAG20832.l| (AE005152) Vng6161h

3815761

[Halobacterium sp. NRC-l] gb| AAG20970.l|

(AE005164) Vng6345h [Halobacterium sp . NRC-l] SEQ ID n~2496

Contig9 from SEQ ID n° 9190 PL-2014.1 3815813 to m No Hits found

3816547 SΞQ ID n~ïl54 pir|]H83457 hypothetical protein PA1508

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 9191 PL-4794.1 3817364 to m 43% (strain PAOl) gb|AAG04897.1 |AE004579_9

3817627 (AEO 04579) hypothetical protein [Pseudomonas aeruginosa] #N/A

Contig9 from SEQ ID n° 9192 PL-2016.1 3817630 to No Hits found

3818364 SEQ ID n~ïl55 pir]|C83157 hypothetical protein PA3907

Contig9 from [imported] - Pseudomonas aerugmosa SEQ ID n° 9193 PL-2017.1 3818413 to m 33% (Strain PAOl) gb|AAG07294.l|AE004808_4

3819045 (AE004808) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n-î.156 pir||H83457 hypothetical protein PA1508

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 9134 PL-4795.1 3819209 to 443 (strain PAOl) gb | AAG04897. l| Ξ004579_9

3819472 (AE004579) hypothetical protem [Pseudomonas aeruginosa] #N/A pir| |D83157 hypothetical protein PA3908

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° S1S5 PL-2018.1 3819475 to m 36% (strain PAOl) gb| AG07295.1 ] E004808_5

38201S7 (AE004808) hypothetical protem [Pseudomonas aeruginosa] SEQ ID n~2157

pir||C83157 hypothetical protein PA3907

Contig9 from [imported] - Pseudomonas aeruginosa

SEQ ID n° 9196 PL-2019.1 3820221 to m 363 (Strain PAOl)_._ gbjAAGO7294.l|AΞ004808_4

382082S (AE004808) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2158

ContigS from__ SEQ ID n° 9197 PL-4796.1 3820831 to m No Hits found

3821175 #N/A pir| |A83157 hypothetical protein PA3905

ContigS from [imported] - Pseudomonas aeruginosa SEQ ID n° 3138 PL-3245.1 3821178 to m 21% (Strain PAOl) ~ gb| AAG0729 .l| AΞ004808_2

3821663 (AΞ004808) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2497 pir| |F82511 vgrG protein VCA0018 [imported] -

ContigS from

Vibrio cholerae (group 01 strain SEQ ID n° 3199 PL-2020.1 3821666 to m 533

N16961) gb|AAF95932.l| (AΞ004345) vgrG protein

3823642

[Vibrio cholerae] SEQ ID n~2160 pir] |A82499 hypothetical protein VCA0110

Contig9 from

[imported] - Vibrio cholerae (group SEQ ID n° 9200 PL-2021.1 3823657 to m 43%

01 Strain N16961) gb| AAF96024.l| (AΞ004353)

3825417 hypothetical protein [Vibrio cholerae] SEQ ID n~2161 pir| [H83457 hypothetical protein PA1508

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 9201 PL-4798.1 3825659 to p 34% (strain PAOl) gb|AAG04897.l|AE004579_9

3825931 (AE004579) hypothetical protein [Pseudomonas aeruginosa] #N/A

Contig9 from emb(CAC18672.l| (AJ251781) BspA protein SΞQ ID n° 9202 PL-2022.1 3825999 to m 793 [Pectobacterium chrysanthemi]

3829334 SEQ ID n~£162

sp | 10740 | DPSD_ECOLI PHOSPHATIDYLSΞRINE

DECARBOXYLASB PROENZYME pir| |A29234 phosphatidylserine decarboxylase (ΞC.j il • 1.65) precursor [validated] - Escherichia coli gb|AAA97059.l| (U14003) phosphatidylserine

Contig9 from decarboxylase [Escherichia coli] gb[AAA83896.l| SEQ ID n° 9203 PL-2023.1 3829361 to m 733 (J03916) phosphatidylserine decarboxylase

3830254 [Escherichia coli] gb]AAC77i20.l| (AΞ000488) phosphatidylserine decarboxylase; phospholipid synthesis [Escherichia coli K12] gb|AAG59359.l|AΞ005649_4^~~(AEO05649) phosphatidylserine decarboxylase; phospholipid synthesis [Escherichia coli 0157 :H7] SEQ ID n~2163

Contig9 from sp|P39286|YJEQ_EC0LI HYPOTHETICAL 39.2 KD SEQ ID n° 9204 PL-2024.1 3830329 to m 82% PROTEIN IN PSD-AMIB INTERGΞNIC REGION

3831384 SEQ ID n~2164 pir| |S56390 hypothetical 23.5K protein (psd-amiB

Contig9 from intergenic région) - Escherichia coli SEQ ID n° 9205 PL-3247.1 3831478 to p 85% gb|AAA3706l.l| (U14003) ORF_o204a [Escherichia

3832023 coli] gb|AAC77122.l| (AΞ000488) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~2498 pir| |A83235 hypothetical protein PA2819

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 9206 PL-4800.1 3832234 to m 403 (strain PAOl) gb JAAG06207.l|AE004708_13

3832380 (AΞ004708) hypothetical protein [Pseudomonas aeruginosa] #N/A pir| |F82453 conserved hypothetical protein

Contig9 from VCA0489 [imported] - Vibrio cholerae SEQ ID n° 9207 PL-4801.1 3832582 to m 453 (group Ol strain N16961) gb| AAF96393.l|

3832914 (AE004380) conserved hypothetical protein

[Vibrio cholerae] #N/A pir| |E82462 conserved hypothetical protein

Contig9 from VCA0422 [imported] - Vibrio cholerae SEQ ID n° 9208 PL-4802.1 3832914 to m 333 (group 01 strain N16961) gb|AAF96328.l|

3833189 (AΞ004376) conserved hypothetical protein

[Vibrio cholerae] #N/A

Sp|P42594|YGJM_EC0LI HYPOTHETICAL 15.0 KD

PROTEIN IN EBGC-UXAA INTERGENIC REGION

ContigS from pir| |G65096 hypothetical protein ygjM - SEQ ID n° 9209 PL-4803.1 3833447 to p 653 Escherichia coli (strain K-12) gb] AAA57883 ,l|

3833803 (U18997) ORF_fl38 [Ξscherichia coli]

gb|AAC76117.l| (AΞ000390) orf, hypothetical protein [Ξscherichia coli K12] ttN/A

Contig9 from dbj |BAB04109.l( (AP001508) BH0390-unknown SEQ ID n° 9210 PL-2025.1 3834067 to m 47% conserved protein [Bacillus halodurans]

3835062 SEQ ID n~2165 pir] |T27169 hypothetical protein Y54G11A.4

Contig9 from

Caenorhabditis elegans emb | CAA22449.1 | SEQ ID n° 9211 PL-2026.1 3835081 to m 31%

(AL034488) predicted using Genefinder

3836271

[Caenorhabditis elegans] SEQ ID n~2166 sp ] 032255 | YVBU_BACSU HYPOTHBTICAL

TRANSCRIPTIONAL REGULATOR YVBU pir| |E70030

Contig9 from transcription regulator LysR family homolog yvbU SEQ ID n° 9212 PL-2027.1 3836420 to 46%

- Bacillus subtilis emb | CAB1540 .1 |

3837337

(Z99121) similar to transcriptional regulator

(LysR family) [Bacillus subtilis] SΞQ ID n~2167

Contig9 from SEQ ID n° 9213 PL-4806.1 3837467 to m No Hits found

3837898 #N/A ContigS from SΞQ ID n° 9214 PL-4807.1 3838086 to p No Hits found

3838280 #N/A Contig9 from gb|AAG59362.l|AE005650_l (AE005650) orf, SΞQ ID n° 9215 PL-2374.2 3838767 to m 81% hypothetical protein [Escherichia coli 0157 :H7]

3839948 SEQ ID n~2547

sp|P31805|YJΞE_ECOLI HYPOTHΞTICAL 16.9 KDA

PROTΞIN IN PSD-AMIB INTΞRGΞNIC RΞGION (URF2) pir| |S56393 hypothetical 16. SK protein (psd-amiB intergenic région) - Escherichia coli gb|AAA20096.l| (L19346) urf2 [Escherichia coli]

ContigS from gb|AAA97064.l| (U14003) urf2 of GenBank ^'SEQ ID n° 9216 PL-3248.2 3840096 to ^_ 753 Accession Number L19346 [Escherichia coli]

3840560 gb|AAC77125.l| (AE000489) orf, hypothetical protein [Escherichia coli K12] gb|AAG59364.l|AE005650_3 (AE005650) orf, hypothetical proteiιr^"""[Ξscherichia coli 0157 :H7

EDL933] dbj |BAB38567.1| (AP002568) hypothetical protein [Escherichia coli 0157 :H7] #N/A gb]AAG59365.l|AE005650_4 (AΞ005650) N- acetylmuramoyl-1-alanine amidase II; a murein

Contig9 from hydrolase [Ξscherichia coli 0157 :H7 EDL933] SΞQ ID n° 9217 PL-2373.3 384053S to 68% dbj |BAB38568.l] (AP002568) N-acetylmuramoyl-1-

3841858 alanine amidase II [Ξscherichia coli

0157 :H7] #N/A

Sp|P1416l|MUTL_SALTY DNA MISMATCH REPAIR PROTEIN

ContigS from MUTL pir| |A33588 mismatch repair protein mutL - SΞQ ID n° 9218 PL-2372.1 3841868 to 753 Salmonella typhimurium gb|AAA27166.1 | (M29687)

3843763 mismatch repair protein [Salmonella typhimurium] SEQ ID n~2545

Contig9 from gb|AAG59367.l|AE005650_6 (AE005650) delta(2)- SΞQ ID n° 9219 PL-2371.1 3843756 to 84% isopentenylpyrophosphate tRNA-adenosine

3844697 transferase [Escherichia coli 0157.-H7] SEQ ID n~2544

sp|P2552l]HFQ_ΞCOLI HOST FACTOR-I PROTEIN (HF-I) pir||S56397 host factor I - Escherichia coli

_dbj |BAA00644.l| (D00743) host factor-I protein

[Escherichia coli] gb|AAC433S7.1 | (U00005) Host

Factor-I (HF-I) [Escherichia coli]

Contig9 from gb|AAA97068.l| (U14003) Host Factor-I (HF-I) SΞQ ID n° 922(T1?L-4810.1 3844808 to 813 TÉscherichia coli] gb|AAC77123.l| (AE00048S^")

3845116 host factor I for bacteriophage Q beta réplication, a growth-related protein

[Ξscherichia coli K12] gb|AAG59368.1 |AΞ005650_7

(AΞ005650) host factor I for bacteriophage Q beta réplication, a growth-related protein [Ξscherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG59369.l|AΞ005650_8 (AΞ005650) GTP - SΞQ ID n° 9221 PL-2370.1 3845213 to 903 binding subunit of protease spécifie for phage

3846493 lambda cil repressor [Escherichia coli 0157 :H7] SEQ ID n~2543 sp|P 5662|HFLK_ECOLI HFLK PROTEIN pir||B43653 probable intégral membrane proteinase (ΞC 3.4.-.-

) hflK - Escherichia coli gb|AAC43399.l| (U00005) putative intégral membrane protein required for high frequency lysogenization by bacteriophage lambda

[Escherichia coli] gb| AAA97070.l| (U14003) CG

Contig9 from Site No. 639; alternate gène name hflA; putative SΞQ ID n° 9222 PL-2369.1 3846599 to 81% intégral membrane protease required for high

3847819 frequency lysogenization by bacteriophage lambda [Ξscherichia coli] gb|AAC77i3l.ι| (AE000489) protease spécifie for phage lambda cil repressor

[Escherichia coli K12] gb |AAG59370.1 |AΞ005650_9

(AE005650) protease spécifie for phage lambda cil repressor [Ξscherichia coli

0157 : H7] SEQ ID n~2541

sp|P12283|PURA__ECOLI ADΞNYLOSUCCINATΞ SYNTHETASE

c SΞQ ID n° 9223 PL-2366.1

Contig9 from pir| |B31965 hypothetical 16K protem (purA 3'

SΞQ ID n° 9224 PL-4814.1 3850472 to 81% _ région) - Escherichia coli

3850897 #N/A pir| [S56404 virulence-associated protein vacB

Contig9 from homolog - Escherichia coli gb |AAA97075.l| SEQ ID n° 3225 PL-2365.1 3850942 to 823 (U14003) vacB [Escherichia coli] gb|AAC77136.l |

3853383 (AΞ000490) putative enzyme [Escherichia coli

K12] SEQ ID n~£538 sp|P3929θ|YJFH_ΞCOLI HYPOTHΞTICAL TRNA/RRNA

METHYLTRANSFERASE YJFH pir||S56405 hypothetical

26.6K protein (vacB-aidB intergenic région) -

ContigS from Escherichia coli gb |AAA97076.1 | (U14003) SEQ ID n° 3226 PL-2364.1 3853511 to 853 ORF_o243 [Escherichia coli] gb|AAC77137.1 |

3854245 (AΞO00490) orf, hypothetical protein

[Escherichia coli K12] gb |AAG59376.1 |AE005651_5

(AΞ005651) orf, hypothetical protein

[Ξscherichia coli 0157 :H7] SEQ ID n~£537

Contig9 from

SEQ ID n° 9227 PL-4815.1 3854549 to sp|P0 358|RS6_ECOLI 30S RIBOSOMAL PROTEIN S6

3854944 #N/A

ContigS from gb|AAG59397.l|AE005652_14 (AE005652) primosomal

SEQ ID n° 9228 PL-4817.1 3854950 to p 83% réplication protein N [Escherichia coli

3855267 0157 :H7] #N/A

sp|P02374|RS18_ΞCOLI 30S RIBOSOMAL PROTEIN S18 pir]|R3ΞC18 ribosomal protein S18 [validated] -

— C

SEQ ID n° 9229 PL-4818.1

protein S18 [Escherichia coli K12] #N/A sp|P02418|RLS_ECOLI 5OS RIBOSOMAL PROTEIN LS pir| |S56428 50S ribosomal chain protein L9 -

Escherichia coli pir[ (R5EC9 ribosomal protein

L9 [validated] - Escherichia coli (strain K-12) emb [CAA27655. l| (X04022) ribosome protein L9 (aa

Contig9 from

1-149) [Escherichia coli] gb|AAA97099.1 | SΞQ ID n° 9230 PL-3250.1 3855538 to p 903

(U14003) 5OS ribosomal subunit protein L9

3855990

[Escherichia coli] gb|AAC77160.1 | (AE000491)

50S ribosomal subunit protein L9 [Ξscherichia

COli K12] gb|AAG59399.l| AE005652_16 (AE005652)

5OS ribosomal subunit protein L9 [Escherichia coli 0157 :H7] SEQ ID n~2501

Contigg from gb|AAC26596.l| (U83S95) putative protease SΞQ ID n° 9231 PL-2363.1 3856282 to 593 [Porphyromonas gingivalis]

3857166 SEQ ID n~2536 Contig9 from gb|AAG28533.l|AF138621_4 (AF198621) cysteine SEQ ID n° 9232 PL-2362.1 3857953 to 503 synthase [Bacillus stearothermophilus]

3858981 SEQ ID n~î535 Contig9 from dbj |BAB06906.l| (AP001518) argininosuccinate SΞQ ID n° 9233 PL-2361.1 3858971 to 57% synthase (citrulline-asparate ligase)

3860161 [Bacillus halodurans] SEQ ID n~£534 Contig9 from pir| \ S16729 hypothetical protein - Synechocystis SΞQ ID n° 9234 PL-2360.1 3860158 to 563 sp. (strain PCC 6803) dbj |BAA18641. l| (D90916)

3860961 hypothetical protein [Synechocystis sp.] SΞQ ID n~2533

sp[P74178(YB78_ΞYNY3 HYPOTHETICAL 69.1 KD

Contig9 from PROTEIN SLL1178 pir||S75808 nodulation protein SΞQ ID n° 9235 PL-2359^1 3860985 to 583 Synechocystis sp. (strain PCC 6803)

3862682 dbj |BAA18267.l| (D90913) nodulation protein

[Synechocystis sp . ] SEQ ID n-2531

Contig9 from emb|CAB92558. l| (AL356812) putative intégral SEQ ID n° 9236 PL-235^~87l7 3862895 to 37% membrane protein. [Streptomyces

3864121 coelicolor A3 (2) ] SEQ ID n~£530 Contig9 from SEQ ID n° 9237 PL-2357.1 3864132 to No Hits found 3865442 SEQ ID n~£529 pir| |D83407 probable transcription regulator

PA1898 [imported] - Pseudomonas aeruginosa (strain PAOl)

Contig9 from gb|AAF01471.l|AF190630_l (AF190630) PhzR SEQ ID n° 9238 PL-2356.1 3865479 to m 423

[Pseudomonas aeruginosa]

3866195 gb|AAG05287.l|AE004616_l (AE004616) probable transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~2528 pir| |S56432 peptidylprolyl isomerase (EC

5.2.1.8) - Escherichia coli gb| AAA97103.l|

Contig9 from

(U14003) ORF_o259a [Ξscherichia coli] SEQ ID n° 9239 PL-2355.1 3866448 to 85% gb|AAC77164.l| (AΞ000492) FKBP-type 22KD

3867086 peptidyl-prolyl cis-trans isomerase

(rotamase) [Ξscherichia coli K12] SEQ ID n~2527

Contig9 from dbj |BAB06239.l[ (AP001515) transposase related SΞQ ID n° 9240 PL-2354.1 3867529 to 21% protein (20) [Bacillus halodurans]

3868554 SEQ ID n~2526 gb]AAG59412.1 ] AΞ005654_1 (AΞ005654) affects pool

Contig9 from of 3 ' -phosphoadenosine-5 ' -phosphosulfate in SEQ ID n° 9241 PL-2353.1 3869408 to 793 pathway of sulfite synthesis [Ξscherichia coli

3870151

0157:H7] SEQ ID n~2525

pir] ]F82061 conserved hypothetical protein

Contig9 from VC2550 [imported] - Vibrio cholerae SΞQ ID n° 9242 PL-2352.1 3870232 to 63? (group 01 strain N16961) gb| AAF95691. l|

3870786 (AE004324) conserved hypothetical protein

[Vibrio cholerae] SEQ ID n-2524

Contig9 from pir| (S56442_hypothetical protein o81 - SΞQ ID n° 9243 PL-4823.1 387107 tcT^~ 793 Escherichia coli

3871283 #N/A sp|P39319|YTFL_ECOLI HYPOTHΞTICAL 49.8 KD

PROTEIN IN CYSQ-MSRA INTERGENIC REGION pir||S56443 hypothetical 49.8K protein (cysq- msra intergenic région) - Escherichia

Contig9 from coli gb|AAA97114.l| (U14003) 0RF_f447 SΞQ ID n° 9244 PL-2351.1 3871395 to 843

[Escherichia coli] gb| AAC77175.1 | (AE000433)

3872726 putative transport protein [Escherichia coli

K12] gb|AAG53416.l|AE005654_5 (AE005654) putative transport protein [Escherichia coli

0157 :H7] SEQ ID n~2523 sp|P2711θ|MSRA_ΞCOLI PEPTIDE METHIONINE

SULFOXIDE REDUCTASΞ (PROTEIN-METHIONINE-S-OXIDE

REDUCTASE) (PEPTIDE MET(O) REDUCTASE) pir||S56444 protein-methionine-S-oxide reductase

(ΞC 1.8.4.6) - Escherichia coli

Contig9 from gb|AAA24399.l| (M89992) peptide methionine SEQ ID n° 9245 PL-2350.1 3872881 to m 71% sulfoxide reductase [Escherichia coli]

3873528 gb|AAA97115.l| (U14003) peptide methionine sulfoxide reductase [Escherichia coli] gb|AAC77l76.l| (AE000493) peptide methionine sulfoxide reductase [Escherichia coli

K12] SEQ ID n~£522

sp|P39320 |YTFM_ECOLI HYPOTHΞTICAL 64.8 KD

C SEQ ID n° 9246 PL-2349.1

[Escherichia coli K12] SΞQ ID n~2520 sp|P3932l| TFN_ECOLI HYPOTHΞTICAL 136.8 KD

Contig9 from PROTΞIN IN MSRA-CHPB INTBRGENIC REGION

SEQ ID n° 9247 PL-2348.1 3875382 to P 73% pir| |H65233 ytfN protein - Escherichia coli

3879155 (Strain K-12) gb|AAC77178. l| (AB000493) orf, hypothetical protein [Ξscherichia coli K12] SΞQ ID n~2519 sp|P39323 |YTFP_ΞCOLI HYPOTHETICAL 12.9 KDA PROTEIN IN MSRA-CHPBI INTERGENIC REGION pir||S56448 hypothetical 12.9K protein (msra- chpbi intergenic région) -

Contig9 from Ξscherichia coli gb| AAA97119. l| (U14003) SEQ ID n° 9248 PL-4825.1 3879158 to 71% 0RF_oll3 [Ξscherichia coli] gb|AAC77179.l|

3879505 (AΞ000493) orf, hypothetical protein [Escherichia coli K12] gb |AAG59420.1|AE005654_9 (AΞ005654) orf, hypothetical protein [Ξscherichia coli 0157.-H7] #N/A sp|P17288|lPYR_ECOLI INORGANIC PYROPHOSPHATASΞ (PYROPHOSPHATE PHOSPHO-HYDROLASE) (PPASE) pir | | PWEC inorganic pyrophosphatase (EC 3.6.1.1) - Escherichia coli gb | AAB88583.1 | (M23550)

ContigS from inorganic pyrophosphatase [Escherichia coli] SEQ ID n° 9249 PL-2347.1 3879605 to m 76% gb| AAA97123.l| (U14003) ppa [Escherichia coli]

3880135 gb|AAC77183.l| (AE000494) inorganic pyrophosphatase [Escherichia coli K12] gb|AAG59424.1 | AΞ005655_3 (AE005655) inorganic pyrophosphatase [Escherichia coli 0157 :H7] SEQ ID n~1518

sp | P09200 | F16P_ECOLI FRUCTOSE-1, 6-BISPHOSPHATASE

(D-FRUCTOSE-1,6-BISPHOSPHATE 1-

PHOSPHOHYDROLASE) (FBPASE) pir | | PAEC fructose- bisphosphatase (EC 3.1.3.11) - Escherichia coli

Contig9 from emb|CAA31062.l| (X12545) fructose-1, 6-

SEQ ID n° 9250 PL-2346.1 3880753 to m 86% bisphosphatase (AA 1-332) [Escherichia coli] —3881757 gb|AAA97Î29.l| (U14003) fructose-1, 6- bisphosphatase [Ξscherichia coli] gb]AAC77189.l| (AΞ000494) fructose- bisphosphatase [Escherichia coli K12] SEQ ID n~SL517

ContigS from gb|AAG59430.l|AE005655_9 (AΞ005655) putative SEQ ID n° 9251 PL-2345.1 3881923 to 823 ligase [Escherichia coli 0157 :H7]

3883293 SEQ ID n~2516 sp|P15282 |ARGR_ECOLI RGININΞ REPRΞSSOR pir| (A33888 arginine repressor protein -

Ξscherichia coli emb|CAA32148.l| (X13968) xerA gène product (AA l - 156) [Escherichia coli] gb|AAA23486.l| (M17532) arginine regulatory protein [Ξscherichia coli] gb|AAA58039.l|

Contig9 from

(U18997) CG Site No. 1011; alternate name Rarg

SEQ ID n° 9252 PL-3253.1 3883338 to m 873

[Escherichia coli] gb |AAC76269. l| (AE000403) 3883808 repressor of arg regulon; cer-mediated site spécifie recombination [Escherichia coli K12] gb|AAG58365.l|AΞ005551_8 (AΞ005551) repressor of arg regulon; cer-mediated site spécifie recombination [Ξscherichia coli 0157:H7] SΞQ ID n~2503 gb|AAG21998.l|AF282309_l (AF282309) malate

ContigS from dehydrogenase [Yersinia pestis]

SEQ ID n° 9253 PL-2344.1 3884263 to 92% gb|AAG21999.l|AF282310_l (AF282310) malate

3885201 dehydrogenase [Yersinia pseudotuberculosis] SEQ ID n~2515

sp|P18837|SFSB_ΞCOLI SUGAR FΞRMΞNTATION

STIMULATION PROTEIN B (NΞR-LIKE PROTEIN) pir| |BVECNP nlp protein - Escherichia coli emb|CAA48736.l| (X58873) Ner-like protein, homologous to Ner protein of

bacteriophages Mu and D108 [Escherichia coli] Contig9 from gb|AAA57383.l| (U18S97) Ner^ïike protein

SEQ ID n° 9254 PL-3254.1 3885430 to m 34%

[Escherichia coli] gb[AAC76220.1 | (AE00039S)

3885696 regulatory factor of maltose metabolism; similar to Ner repressor protein of phage Mu

[Escherichia coli K12] ^~gb|AAG58322.1 |AE005547_8

(AEO05547) regulatory factor of maltose metabolism; similar to Ner repressor protein of phage Mu [Escherichia coli 0157 :H7] SEQ ID n~2504 sp|P0704θ|RPCl_BPD10 REPRESSOR PROTEIN CI

Contig9 from pir| |S07370 probable repressor protein - phage SEQ ID n° 9255 PL-4828.1 3885921 to p 48% D108 emb|cAA27474.l| (X03847) put. repressor

3886229 protein (aa 1-174) [Bacteriophage D108] #N/A sp|P07040|RPClJ3PD10 RΞPRΞSSOR PROTEIN CI

ContigS from pir] |S07370 probable repressor protein - phage SEQ ID n° 3256 PL-4823.1 3886285 to p 24% D108 emb|CAA27474.l] (X03847) put. repressor

3886686 protein (aa 1-174) [Bacteriophage D108] #N/A sp | 13641 | ISPB_ΞCOLI OCTAPRENYL-DIPHOSPHATE

SYNTHASE (OCTAPRENYL PYROPHOSPHATE

SYNTHETASE) (OPP SYNTHETASE) pir| |E65109

ContigS from octaprenyl-diphosphate synthase (EC 2.5.1.-) - SEQ ID n° S257 PL-2343.1 3886708 to 85?

Escherichia coli gb|AAA57988. l| (U18997)

3887673

ORF_o323 [Ξscherichia coli] gb] AAC76219.l|

(AE000399) octaprenyl diphosphate synthase

[Escherichia coli K12] SEQ ID n~2514

sp|P02422 |RL21_ECOLI 50S RIBOSOMAL PROTEIN L21 pir| |R5EC21 ribosomal protein L21 [validated] -

Ξscherichia coli dbj |BAA02525.l| (D13267) ribosomal protein L21 [Bscherichia coli]

Contig9 from gb|AAA57987.l| (U18997) 50S ribosomal subunit

SEQ ID n° 9258 PL-4831.1 3887931 to p 84% protein L21 [Ξscherichia coli] gb|AAC76218.1 ]

3888239

(AΞ000339) 50S ribosomal subunit protein L21

[Escherichia coli K12] gb |AAG58320.1 |AE005547_6

(AΞ005547) 50S ribosomal subunit protein L21

[Ξscherichia coli 0157 :H7] #N/A sp|P02427|RL27_ΞCOLI 50S RIBOSOMAL PROTEIN L27 pir| |R5EC27 ribosomal protein L27 [validated] -

Ξscherichia coli dbj |BAA0 526.l| (D13267) ribosomal protein L27 [Escherichia coli]

ContigS from gb|AAA57386.l| (U18S37) 50S ribosomal subunit SΞQ ID n° 9259 PL-4833.1 3888259 to 92% protein L27 [Escherichia coli] gb| AAC76 17.l|

3888516 (AΞ000399) 50S ribosomal subunit protein L27

[Ξscherichia coli K12] gb|AAG58319.l|AE005547_5 (AE005547) 50S ribosomal subunit protein L27 [Escherichia coli

0157:H7] #N/A

Contig9 from gb|AAG58317.l|AΞ005547_3 (AΞ005547) putative GTP

SΞQ ID n° 9260 PL-2342.1 3888769 to 81% binding factor [Ξscherichia coli 0157:H7]

3889944 SΞQ ID n~2513

sp|P24228| BP4_ECOLI PENICILLIN-BINDING PROTEIN

4 PRECURSOR (PBP-4) [INCLUDES: D-

ALANYL-D-ALANINΞ CARBOXYPEPTIDASE (DD-PEPTIDASE)

(DD-CARBOXYPEPTIDASE) ; D-ALANYL-D-ALANINE-

ENDOPEPTIDASΞ (DD-ENDOPEPTIDASE) ]

pir| |A54535 serine-type D-Ala-D-Ala carboxypeptidase (EC 3.4.16.4) precursor -

Escherichia coli emb|CAA42070.l| (X59460)

Contig9 from penicillin-binding protein 4 (PBP4) SEQ ID n° 9261 PL-2341.1 3890012 to m 753 [Bscherichia coli] emb|CAA42643. l| (X60038) D-

3891538 alanyl-D-alanme carboxypeptidase [Escherichia coli] gb|AAA57383.l| (U18S97) D-alanyl-D- alanine carboxypeptidase, fraction B

[Escherichia coli] gb| AAA97505.1 | (U01376) ampicillin-binding protein [Escherichia coli] gb|AAC76214.l| (AE000399) D-alanyl-D-alanine carboxypeptidase, fraction B; penicillin-binding protein 4 [Escherichia coli

K12] SEQ ID n~2512 Sp|P 1346|GRΞA_EC0LI TRANSCRIPTION ELONGATION

FACTOR GREA (TRANSCRIPT CLΞAVAGΞ FACTOR

GRΞA) pir| | JQ0752 suppressor protein greA -

Contig9 from Ξscherichia coli pdb | 1GR | Gréa Transcript SEQ ID n° 9262 PL-3256.1 3891721 to 94% Cleavage Factor From Ξscherichia Coli

3892197 emb|CAA38521.l| (X54718) GreA protein

[Escherichia coli] gb| AAA97506.1 | (U01376) transcription elongation factor [Ξscherichia coli] SEQ ID n~2505

sp|P 2550|YHBY_ECOLI HYPOTHETICAL 10.8 KD

PROTEIN IN FTSJ-GREA INTERGΞNIC REGION (097) pir| |F65108 hypothetical 10.8 kD protein_in ftsj gréa intergenic région - Ξscherichia

Contig9 from coli (strain K-12) gb|AAA57981.l| (U183S7)

SEQ ID n° 9263 PL-4835.1 3892330 to m 82%

ORF_o97 [Ξscherichia coli] gb|AAC76212. l| 3892623

(AΞ000398) orf, hypothetical protein

[Ξscherichia coli K12] gb | AG58314.1 |AE005546_8

(AΞ005546) orf, hypothetical protem

[Ξscherichia coli 0157 :H7] #N/A

Contig9 from

SΞQ ID n° 9264 PL-4836.1 3892661 to m No Hits found

3892795 #N/A sp|P28692|RRMJ_ΞCOLI RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J (RRNA (URIDINE- '

0-) -MΞTHYLTRANSFΞRASΞ) (23S RRNA M2U2552

MΞTHYLTRANSFERASE) (CΞLL DIVISION PROTEIN FTSJ) pir||S35108 23S rRNA methyltransferase (ΞC

Contig9 from 2.1.1.-) [validated] - Ξscherichia SEQ ID n° 9265 PL-2340.1 3892764 to 923 coli gb|AAA23812.l| (M83138) ftsJ [Ξscherichia

3893393 coli] gb|AAA57980.l| (U18997) ftsJ [Ξscherichia coli] gb|AAA97507.l| (U01376) regulatory protein [Ξscherichia coli] gb|AAC76211.l|

(AΞ000398) cell division protein [Escherichia coli K12] gb|AAG58313.l|AΞ005546_7 (AΞ005546) cell division protein [Escherichia coli 0157 :H7] SΞQ ID n~2511

Contig9 from gb|AAA97508.l| (U01376) ATP-binding protein SEQ ID n° 9266 PL-2339.1 3893442 to 923 [Ξscherichia coli]

3895403 SEQ ID n-2509 gb|AAA57978 ,l| (U18997) dihydropteroate synthase

[Ξscherichia coli] gb|AAC76209.l| (AE000398)

ContigS from

7 , 8 -dihydropteroate synthase [Escherichia coli SEQ ID n° 9267 PL-2338.1 3895486 to 823

K12] gb|AAG58311.l|AE005546_5 (AE005546) 7,8-

3896331 dihydropteroate synthase [Escherichia coli

0157:H7] SEQ ID n~2508

Contig9 from gb|AAG58310.l|AE005546_4 (AE005546) similar to SEQ ID n° 9268 PL-2337.1 3896328 to 873 phosphoglucomutases and phosphomanno utases

3897665 [Escherichia coli 0157:H7] SEQ ID n~î.507 sp|P33582]^~SÊCG_ECOLI PROTEIN-ΞXPORT MΞMBRANE

PROTEIN SECG (PREPROTEIN TRANSLOCASE BAND 1

SUBUNIT) (P12) pir| |S40402 protein-export

Contig9 from protein âëcGT^" Escherichia coli dbj |BAA03930. l| SEQ ID n° 9269 PL-4839.1 3897842 to 81% (D16463) pl2 [Escherichia coli] gb|AAA57976.l|

3898180 (U18997) pl2 [Escherichia coli] gb | AAA97511.1 j

(U01376) membrane protein [Escherichia coli] gb|AAC76207.l| (AE000398) protein export - membrane protein [Ξscherichia coli K12] #N/A

Contig9 from SEQ ID n° 9270 PL-4840.1 3898280 to No Hits found

3898468 #N/A pir] |WMΞCN5 nus operon 15K protein - Ξscherichia coli gb|AAA57973.l| (U18997) gtg start;

Contig9 from différences from database entry [Ξscherichia

SEQ ID n° 9271 PL-3257.1 3898660 to 893 coli] gb|AAC76204.l| (AE000397) orf,

3899124 hypothetical protein [Escherichia coli K12] gb|AAG58306.l|AE005545_8 (AE005545) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~2506 sp|P03003 |NUSA_ECOLI N UTILIZATION SUBSTANCE

PROTEIN A (NUSA PROTEIN) (L FACTOR) pir| | FJEC transcription termination-antitermination factor nusA - Escherichia coli

Contig9 from gb|AAA57972.l| (U18997) L factor [Escherichia SEQ ID n° 9272 PL-2336.1 3899146 to 91% coli] gb|AAC76203.l| (AΞ000397) transcription

3900654 pausing; L factor [Escherichia coli K12] gb|AAG58305.l|AE005545_7 (AE005545) transcription pausing; L factor [Escherichia coli 0157 :H7] SEQ ID n~2506 sp|Q9ZF3l|lF2_SALTY TRANSLATION INITIATION

Contig9 from

FACTOR IF-2 emb| CAA05549.1 | (AJ002552) SEQ ID n° 9273 PL-2334.1 3900679 to 89% initiation factor IF2-alpha [Salmonella

3903408 typhimurium] SEQ ID n-2504

ContigS from sp | 034272 |RBFA_YEREN RIBOSOMB-BINDING FACTOR A SEQ ID n° 9274 PL-3259.1 3903474 to 733 emb[CAA71698.l| (Y10692) yhbB [Yersinia

3903884 sp|P0317l

B

(PS155

(URACIL HYDROLYASΞ) (P35 PROTEIN) pir| |QSEC35 tRNA-pseudouridine synthase (EC

5.4. SS.-) truB [validated] -

Contig9 from

Escherichia coli emb | CAA32021.1 | (X13775) P35

SΞQ ID n° 9275 PL-2332.1 3S03884 to 78% gène product (AA I^""-^""314) [Escherichia coli]

3304831 emb|CAA31635.l| (X13270) P35 gène product (AA 1 •

314) [Escherichia coli] gb| AAC76200.1]

(AE000397) tRNA pseudouridine 5S synthase

[Escherichia coli K12] gb| AAG58302.1 | AE005545_4

(AEO05545) tRNA pseudouridine 5S synthase

[Escherichia coli 0157 :H7] SEQ ID n~2502 sp|P41120 |RS15_PHOLU 30S RIBOSOMAL PROTEIN S15

Contig9 from pir|[S38882 ribosomal protein S15 - Xenorhabdus SEQ ID n° 9276 PL-4844.1 3904954 to p 88% luminescens emb|CAA53670.l| (X76069) ribosomal

3905223 protein S15 [Photorhabdus luminescens] #N/A sp | P41121 | PNP_PHOLU POLYRIBONUCLΞOTIDΞ

NUCLEOTIDYLTRANSFERASE (POLYNUCLEOTIDE

Contig9 from PHOSPHORYLASE) (PNPASE) (CAP87K) pir|[S38883 SEQ ID n° 9277 PL-2331.1 3905469 to p 96% polyribonucleotide nucleotidyltransferase (EC

3307538 2.7.7.8) - Xenorhabdus luminescens emb|CAA53671.l| (X 6069 ) polynucléotide phosphorylase [Photorhabdus luminescens] SEQ ID n-2501

sp|P3S833|NLPI_ΞCOLI LIPOPROTΞIN NLPI PRECURSOR pir| |G65106 hypothetical 33.6 kD protein in dead pnp intergenic région - Escherichia

Contig9 from coli (strain K-12) gb| AAA57366.1 ] (U18997) SΞQ ID n° 9278 PL-2330.1 3907846 to 87% 0RF_f 34 [Escherichia coli] gb | AAC76137.1 |

3908730 (AEO 00397) putative control proteins lEscherichia coli K12] gb | AAG58299.1 | AΞ005545_1

(AΞ005545) putative control proteins

[Ξscherichia coli 0157 :H7] SΞQ ID n~£500

ContigS from gb|AAG58298.l|AE005544_12 (AE005544) inducible

SΞQ ID n^σ 9279 PL-2329.1 3308887 to 86% ATP-independent RNA helicase [Escherichia coli

3910821 0157 :H7] SΞQ ID n~2498 sp|P94532|CSTA_BACSU CARBON STARVATION PROTEIN A

HOMOLOG pir| |A69609 carbon starvation protein

Contig9 from cstA [similarity] - Bacillus subtilis

SΞQ ID n° 9280 PL-2328.1 3910960 to m 83% emb|CAA99596.l| (Z75208) carbon starvation

3912762 induced protein [Bacillus subtilis] emb|CAB14831.l| (Z99118) carbon starvation- induced protein [Bacillus subtilis] SEQ ID n~2497 sp|P33356|YEHT_ECOLI HYPOTHΞTICAL 27.3 KD PROTEIN IN MOLR-BGLX INTERGENIC RΞGION pir| |D64380 yehT protein - Escherichia coli (strain K-12) gb]AAA60488. l] (U00007) yehT

Contig9 from [Escherichia coli] gb|AAC75186.l| (AE000301)

SEQ ID n° S281 PL-2327.1 3912S33 to m 86% orf, hypothetical protein [Ξscherichia coli K12]

3313655 dbj |BABlS554.l| (AP000400) hypothetical protein [Ξscherichia coli 0157 :H7] gb|AAG571S3.l|AE00543S_12 (AE005439) orf, hypothetical protein [Escherichia coli 0157.-H7] prf | | 2014253V yehT gène [Escherichia coli] SΞQ ID n~24S6

sp|P33357]YEHU_ECOLI HYPOTHETICAL 62.1 KD

PROTEIN IN MOLR-BGLX INTERGENIC REGION

ContigS from PRECURSOR pir| |E64980 hypothetical 62.1 kD SEQ ID n° 9282 PL-2326.1 3913652 to m 803 protein in molR-bglX intergenic région -

3914683 Ξscherichia coli (strain K-12) gb|AAC75187.l|

(AΞ000301) putative 2-component sensor protein

[Ξscherichia coli K12] SEQ ID n~2495

Contig9 from gb|AAG53985.l|AF327444_l (AF327444) putative SEQ ID n° 9283 PL-4846.1 3914803 to p 753 transposase A [Ξrwinia herbicola]

3915243 #N/A ContigS from gb|AAG53986.l|AF327444_2 (AF327444) putative SEQ ID n° 3284 PL-3260.1 3315246 to p 773 transposase B [Ξrwinia herbicola]

3315641 SEQ ID n~2510 dbj |BAB19555.l| (AP000400) hypothetical protein

Contig9 from [Escherichia coli 0157 :H7] SEQ ID n° 9285 PL-2325.1 3915625 to m 783 gb|AAG57134.l|AE005433_13 (AΞ005433) putative 2 -

3916272 component sensor protein [Ξscherichia coli

0157:H7] SEQ ID n~£494 pir| |G83220 hypothetical protein PA3402

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 9286 PL-2324.1 3916510 to 76% (strain PAOl) gb| AAG06790.l|AΞ004761_6

3917481 (AE004761) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2493 pir|[F83220 hypothetical protein PA3401

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 3287 PL-2323.1 3317489 to 663 (strain PAOl) gb] AAG06789.1 | AE004761_5

3918634 (AE004761) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2492 pir| |E83220 hypothetical protein PA3400

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 9288 PL-2322.3 3918634 to 643 (strain PAOl) gb] AAG06788.1] AE004761_4

3919782 (AE004761) hypothetical protein [Pseudomonas aeruginosa] #N/A

ref |NP_046944.l| gp48 [Bacteriophage N15]

ContigS from pir| |T13135 protein gp48 - phage N15 SΞQ ID n° 9289 PL-4850.2 3920067 to 643 gb|AAC19087.l| (AF064539) gp48 [Bacteriophage

3920354

N15] ^" #N/A

ContigS from

SΞQ ID n° 9290 PL-2321.1 3920465 to No Hits found

3921007 SEQ ID n~2490 sp|P39823 |PSΞ_BACSU CDP-DIACYLGLYCEROL--SΞRINE O

PHOSPHATIDYLTRANSFERASE

(PHOSPHATIDYLSERINE SYNTHASΞ) pir | |A55537

CDPdiacylglycerol- -^"serine 0-

Contig9 from phosphatidyltransferase (ΞC 2.7.8.8) SΞQ ID n° 9291 PL-2320.1 3920997 to m 28% pssA [validated] - Bacillus subtilis

3921620 dbj |BAA07225.l| (D38022) phosphatidylserine synthase [Bacillus subtilis] emb|CAB12021. l|

(Z99105) phosphatidylserine synthase [Bacillus subtilis] dbj |BAA33124.l| (AB006424)

PHOSPHATIDYLSΞRINΞ SYNTHASΞ [Bacillus subtilis] SEQ ID n~2489 pir] [B82579 peptide synthase XF2276 [imported] -

ContigS from

Xylella fastidiosa (strain 9a5c) SΞQ ID n° 9232 PL-2313.1 3321617 to 42% gb|AAF85075.l|AE004039_10 (AE004039) peptide

3923203 synthase [Xylella fastidiosa] SEQ ID n~2487 pir| |C65084 hypothetical protein b2981 -

Contig9 from Escherichia coli (strain K-12) gb|AAA69l48.1 |

SΞQ ID n° 9293 PL-2318.1 3923200 to m 17% (U28377) ORF_f390 [Escherichia coli]

3924255 gb|AAC76017.l| (AE000381) orf, hypothetical protein [Escherichia coli K12] SEQ ID n-2 86 ref |NP_069544. l| phosphoenolpyruvate synthase

(ppsA) [Archaeoglobus fulgidus] sp | 029548 | PPSA_ARCFU PROBABLΞ

Contig9 from PHOSPHOENOLPYRUVATE SYNTHASE (PYRUVATE, WATER

SΞQ ID n° 9294 PL-2317.1 3924248 to 183 DIKINASE) (PEP SYNTHASE) pir]|F69338

3927013 pyruvate, ater dikinase (EC 2.7.9.2) -

Archaeoglobus fulgidus gb| AAB9053 .1 |

(AE001056) phosphoenolpyruvate synthase (ppsA)

[Archaeoglobus fulgidus] SEQ ID n~2485

sp | Q58116 | HMDH_MΞTJA 3 -HYDROXY-3 -METHYLGLUTARYL-

COENZYME A REDUCTASE (HMG-COA REDUCTASE)

Contig9 from pir| |A64388 3 -hydroxy-3 -methylglutaryl coenzyme SΞQ ID n° 9295 PL-2316.1 3927158 to 26% A reductase (EC 1.1.1.-) -

(U67517) 3 -hydroxy-3 -methylglutaryl coenzyme A reductase [Methanococcus jannaschii] SEQ^" i n~^~î484

Contig9 from

SΞQ ID n° 9296 PL-2315.1 3929680 to m No Hits found

3930570 SΞQ ID n-2483

ContigS from

SΞQ ID n° 9297 PL-4853.1 3930710 to m No Hits found

3930943 #N/A sp|P45474|YHBT_BCOLI HYPOTHETICAL 19.7 KD

PROTΞIN IN SOHA-MTR INTERGENIC REGION (F174) pir| |A65106 hypothetical 19.7 kD protein in sohA mtr intergenic région - Escherichia

Contig9 from coli (strain K-12) gb|AAA57960.l| (U18997) SΞQ ID n° 9298 PL-4854.1 3931245 to

ORF_fl74 [Ξscherichia coli] gb| AAC76191.1 |

3931487

(AE000396) orf, hypothetical protein

[Escherichia coli K12] gb | AAG58293.1 | AE005544_7

(AΞ005544) orf, hypothetical protein

[Ξscherichia coli 0157 :H7] #N/A sp|P45473 |YHBS_ECOLI HYPOTHETICAL 18.5 KDA

PROTEIN IN SOHA-MTR INTΞRGΞNIC REGION pir] [H65105 hypothetical protein b3156 -

Escherichia coli (strain K-12) gb| AA57959.1 |

Contig9 from (U18997) ORF_fl67; end overlaps end of olOO by SEQ ID n° 9299 PL-3261.1 3931537 to 70% 14 bases,- start overlaps fl74, other

3932040 starts possible [Escherichia coli] gb|AAC76130.l| (AB000336) orf, hypothetical protein [Escherichia coli K12] gb|AAG58292.l|AΞ005544_6 (AΞ005544) orf, hypothetical protein [Ξscherichia coli 0157 :H7] SΞQ ID n~2511

sp|P45472|YHBQ_ECOLI HYPOTHETICAL 11.3 KD

C SΞQ ID n° 9300 PL-4855.1

[Ξscherichia coli K12] #N/A

Contig9 from gb]AAG55174.l|AΞ005261_4 (AΞ005261) orf, SEQ ID n° 9301 PL-4856.1 3932598 to 603 hypothetical protein.. [Escherichia coli 0157 :H7]

3932849^" #N/A sp|P4547l|YHBP_ECOLI HYPOTHETICAL 16.8 KD

PROTEIN IN SOHA-MTR INTERGENIC REGION (F1 7) pir]|F65105 hypothetical protein yhbP -

Contig9 from

Escherichia coli (strain K-12) gb|AAA57957.l| SEQ ID n° 9302 PL-3262.1 3932973 to 603

(U18997) ORF_fl47; end overlaps end of ol86 by

3933404

20 bases [Escherichia coli] gb]AAC76188.l| (AE000336) orf, hypothetical protein [Escherichia coli K12] SΞQ ID n~2512 sp|P3S32S|NRDG_ECOLI ANAEROBIC RIBONUCLEOSIDE-

TRIPHOSPHATE REDUCTASΞ ACTIVATING PROTΞIN

(CLASS III ANAEROBIC RIBONUCLEOTIDE REDUCTASE

SMALL COMPONENT) pir| |A55692 anaerobic ribonucleotide reductase aetivase (EC

1.97.1.-) - Ξscherichia coli

Contig9 from gb|AAA97134.l| (U14003) ORF_fl54 [Escherichia

SEQ ID n° 9303 PL-3263.1 3933407 to m 80% coli] emb|CAA86937.l| (Z46865) aetivase for

3933871 anaerobic ribonucleoside triphosphate reductase [Escherichia coli] gb| AAC77194. l|

(AΞ000495) anaerobic ribonucleotide reductase activating protein [Escherichia coli

K12] gb|AAG59434.l|AΞ005656_2 (AΞ005656) anaerobic ribonucleotide reductase activating protein [Escherichia coli 0157 :H7] SEQ ID n~2513

Contig9 from gb|AAG5S435.l|AE005656_3 (AΞ005656) anaerobic SEQ ID n° S304 PL-2314.1 33338S1 to m 87% ribonucleoside-triphosphate reductase

3936029 [Escherichia coli 0157 :H7] _ SEQ ID n~£482 pir| |S5646S hypothetical 13.5K protein (mgtA-

Contig9 from pyrl intergenic région) - Ξscherichia

SEQ ID n° 9305 PL-4857.1 3936280 to m 843 coli gb|AAAS7140.l| (U14003) ORF_fl41

3936666 [Escherichia coli] gb| AC77200.1 | (AE000495) orf, hypothetical protein [Escherichia coli K12] #N/A sp | PO84211 PYRI_SALTY ASPARTATE

CARBAMOYLTRANSFERASE REGULATORY CHAIN

- - Contig9 from pir| | DTEBCT aspartate carbamoyltransferase (BC

SEQ ID n° 9306 PL-3264.1 3936884 to m 733

2.1.3.2) regulatory chain -

3937348 Salmonella typhimurium emb|CAA29130.l| (X05641) pyrl (AA 1-153) [Salmonella typhimurium] SEQ ID n~2514

Contig9 from SEQ ID n° 9307 PL-4859.1 3937332 to m No Hits found

3937511 #N/A Contig9 from SEQ ID n° 3308 PL-1S53.1 3S38404 to No Hits found

3939924 SEQ ID n~2085 pir| |A82295 conserved hypothetical protein

Contig9 from VC0673 [imported] - Vibrio cholerae SEQ ID n° 9309 PL-1952.1 3940341 to 433 (group 01 strain N16961) gb|AAF93838.l|

3S41135 (AE004153) conserved hypothetical protein

[Vibrio cholerae] SΞQ ID n~2084

Contig9 from pdb|lF3l|A Chain A, Crystal Structure of Tn5 SΞQ ID n° 9310 PL-1951.1 3941327 to m 57% Transposase Complexed With Transposon

3942709 Ξnd Dna SΞQ ID n~2083 Contig9 from SΞQ ID n° 9311 PL-4863.1 3942720 to m No Hits found

3343031 #N/A ContigS from gb|AAF01338.l|AF190426_2 (AF190426) aspartate SΞQ ID n° 9312 PL-1S50.1 3S4385S to 91% transcarbamylase catalytic subunit [Erwinia

3344782 herbicola] SEQ ID n~2082

Contig9 from gb|AAG59453.l|AΞ005657_13 (AΞ005657) ornithine SEQ ID n° 9313 PL-1S49.1 3945089 to m 843 carbamoyltransferase 1 [Ξscherichia coli

3946105 . 0157:H7] SΞQ ID n~2080 sp | 37163 | YJGD_ΞCOLI HYPOTHΞTICAL 15.6 KD

PROTEIN IN ARGI-VALS INTERGΞNIC REGION (0138)

pir| |S56480 hypothetical 15.6K protein (argl-

Contigg from valS intergenic région) - Escherichia SEQ ID n° 9314 PL-3265.1 3946270 to p 67* coli gb|AAA97151.l| (U14003) 0RF_O138

3946677 [Escherichia coli] gb |AAC77212.1 | (AE000496) orf, hypothetical protein [Escherichia coli K12] gb|AAG59454.l|AE005657_14 (AΞ005657) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~2515

Contig9 from gb|AAC38630.l| (AF047028) insecticidal toxin

SEQ ID n° 9315 PL-1948.1 3946792 to m 563 complex protein TccC [Photorhabdus

3949602 luminescens] SEQ ID n~2079

Contig9 from dbj |BAB03889.l| (AP001507) amino acid ABC

SEQ ID n≈ 9316 PL-1947.1 3349959 to m 61% transporter (amino acid-binding protein)

3950732 [Bacillus halodurans] SEQ ID n-2078

Contig9 from gb|AAG24255.l| (AY009114) Yckl [Bacillus

SEQ ID n° 9317 PL-1946.1 3950820 to m 703 subtilis]

3951584 SEQ ID n~2077

Contig9 from dbj |BAB03890.1| (AP001507) amino acid ABC

SEQ ID n° 9318 PL-1945.2 3951562 to 683 transporter (permease) [Bacillus

3952263 halodurans] SEQ ID n~2076

Contig9 from dbj |BAB03889.1| (AP001507) amino acid ABC

SEQ ID n° 9319 PL-2262.2 3952659 to 62? transporter (amino acid-binding protein)

3953432 [Bacillus halodurans] SEQ ID n~£425

Contig9 from gb|AAG59457.l|AE005657_17 (AE005657) valine tRNA

SΞQ ID n° S320 PL-2263.1 3953869 to 88% synthetase [Escherichia coli 0157:H7]

3956766 SEQ ID n~2426

Contig9 from gb|AAG59458.l|AΞ005657_18 (AE005657) DNA

SEQ ID n° 3321 PL-3267.1 3956780 to m 67% polymerase III, chi subunit [Escherichia coli

3957229 0157 :H7] SEQ ID n~2516

sp|P11648|AMPA_ECOLI CYTOSOL AMINOPEPTIDASE

(LEUCINE AMINOPEPTIDASE) (LAP) (LEUCYL

AMINOPEPTIDASΞ) (AMINOPΞPTIDASΞ A/l) pir| | APΞCA leucyl aminopeptidase (ΞC 3.4.11.1) A -

Ξscherichia coli emb| CAA33225. l| (X15130)

Contig9 from aminopeptidase A/I (AA 1 - 503) [Ξscherichia SEQ ID n^< 9322 PL-2264.1 3357233 to 92? coli] gb|AAA97157.l| (U14003) aminopeptidase

3958813 A/l [Ξscherichia coli] emb|CAA60164.l| (X86443) aminopeptidase A [Ξscherichia coli] gb|AAC77217.l| (AΞ000496) aminopeptidase A/l

[Escherichia coli K12] gb [ AAG59459.1 | AΞ005658_1

(AE005658) aminopeptidase A/l [Escherichia coli

0157:H7] SEQ ID n~2427 sp|P3934θ|YJGP_ECOLI HYPOTHETICAL 40.4 KD

PROTEIN IN PEPA-GNTV INTERGENIC REGION (0366) pir]|S56487 hypothetical 40.4K protein (pepa-

Contig9 from gntv intergenic région) - Escherichia

SEQ ID n° 9323 PL-2265.1 3959099 to 77% coli gb|AAA37158.l] (U14003) ORF_o366

3960199 [Escherichia coli] gb|AAC77218.l| (AE000437) orf, hypothetical protein [Ξscherichia coli K12] gb|AAG53460.l[AΞ005658_2 (AΞ005658) orf, hypothetical protein [Ξscherichia coli 0157.-H7] SΞQ ID n~2428 sp|P3334l|YJGQ_ΞC0LI HYPOTHETICAL 39.8 KD

PROTEIN IN PEPA-GNTV INTERGENIC REGION (0361) pir| | S56488 hypothetical 39.8K protein (pepa-

Contig9 from gntv intergenic région) - Escherichia SΞQ ID n° 9324 PL-2266.1 396019S to p 83% coli gb|AAA97159.l| (U14003) ORF_o361

3361278 [Escherichia coli] gb|AAC77219.l| (AE000497) orf, hypothetical protein [Escherichia coli K12] gb[AAG59461.l|AE005658_3 (AE005658) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~2429 pir] |H64765 yaiH protein - Ξscherichia coli

ContigS from gb|AAC73479.l| (AE000144) putative enzyme SEQ ID n° 3325 PL-2267.1 3961391 to 603 [Escherichia coli K12]

3962653 gb|AAG54722.l|AE005216_10 (AΞ005216) putative enzyme [Ξscherichia coli 0157 :H7] SΞQ ID n~2430

Contigs from SEQ ID n° 9325 PL-4867.1 3963089 to No Hits found

3963184 #N/A

Sp|P39347|lNTB_ECOLI PROPHAGΞ P4 INTEGRASE

(INT(P4)) pir||S56496 prophage P4 integrase -

ContigS from

Escherichia coli gb]AAA97l67.l| (U14003) SEQ ID n° S327 PL-2268.1 - —3363402 to 733

ORF_o396 [Escherichia coli] gb| AAC77227.l|

3964658

(AE000498) prophage P4 integrase [Escherichia coli K12] SEQ ID n-2431

Contig9 from

SEQ ID n° 9328 PL-2269.1 3964709 to No Hits found

3965656 SEQ ID n~2432

Contig9 from gb|AAF06963.l|AF157599_2 (AF157599) Eco0109IREP

SEQ ID n° 9329 PL-4870.1 3965759 to m 65% [Ξscherichia coli]

3966022 #N/A

Contig9 from gb|AAF22961.l]AF157489_l (AF157489) Pin

SEQ ID n° 9330 PL-4871.1 3966139 to 53% [Photorhabdus luminescens]

3966426 #N/A

Contig9 from

SEQ ID n° 9331 PL-4872.1 3966491 to No Hits found

3966664 #N/A

Contig9 from gb|AAF06963.l|AF157599_2 (AF157599) ΞcoOlOSIREP

SEQ ID n° 9332 PL-4873.1 3966693 to m 65% [Ξscherichia coli]

3966953 #N/A

Contig9 from pir| | A36134 RepA protein - Escherichia coli

SΞQ ID n° 9333 PL-2270.1 3967488 to m 223 plasmid TF-FC2 gb|AAA27381.l| (M73777)

3968630 réplication protein A [Plasmid pTF-FC2] SΞQ ID n~2434

Contig9 from ref |NP_052245.l| Orf3 [Francisella tularensis]

SEQ ID n° 9334 PL-2271.1 3968784 to 403 gb|AAC12337.l| (AF055345) Orf3 [Francisella

3969650 tularensis] SEQ ID n~2435

Contig9 from

SΞQ ID n° 9335 PL-4877.1 3970142 to p No Hits found

3970270 #N/A

Contig9 from

SEQ ID n° 9336 PL-4878.1 3970239 to p No Hits found

3970550 #N/A

Contig9 from gb|AAG5885S.l|AE005538_3 (AE005598) orf;

SEQ ID n° 9337 PL-4879.1 3970653 to 78? hypothetical protein [Escherichia coli 0157 :H7]

3971012 #N/A

Contig9 from gb|AAG58860.l|AΞ005598_4 (AE005598) orf;

SEQ ID n° 9338 PL-4881.1 3970996 to 81%

hypothetical protein [Escherichia coli 0157 :H7]

3971319 #N/A

ContigS from

SEQ ID n° 9339 PL-4882.1 3971322 to No Hits found

3971504 #N/A

Contig9 from

SΞQ ID n° 9340 PL-2272.1 3S71437 ter p No Hits found

3972873 SEQ ID n~2436

Contig9 from

SΞQ ID n° 9341 PL-4883.1 3972863 to No Hits found

3973174 #N/A

Contig9 from

SEQ ID n° 9342 PL-2273.1 3973224 to No Hits found

3973979 SEQ ID n~2437

Contig9 from

SEQ ID n° 9343 PL-2274.1 3973976 to p No Hits found

3974968 SEQ ID n~2438

Contig9 from gb|AAF06962.l|AF157599_l (AF157599) P4 integrase

SEQ ID n° 9344 PL-2275.1 3975465 to 81% like protem [Escherichia coli]

3976730 SΞQ ID n~2439 ref |NP_050966.l| P5 [Bacteriophage APSE-l]

Contig9 from sp|Q9TlU3|REGQ_BPAPS PROBABLE ANTITERMINATION

SEQ ID n° 9345 PL-3268.1 3977144 to 513

PROTEIN Q (P5) gb| AAF03993.1 | F157835_56

3977575

(AF157835) P5 [Bacteriophage APSB-i] SΞQ ID n~2517

Contig9 from gb|AAA64865.l| (U23723) orf732 [Escherichia

SΞQ ID n° 9346 PL-2276.1 3977669 to m 563 coli]

3979894 SEQ ID n~2440

Contig9 from gb|AAA64864.l| (U23723) orf300 [Ξscherichia

SΞQ ID n° 9347 PL-2277.1 3979917 to m 453 coli]

3981038 SEQ ID n~î441

ref |NP_058387.l| orf; hypothetical protein

Contig9 from

[Salmonella typhi] gb] AAF70012.l| AF250878_173 SΞQ ID n° 9348 PL-4886.1 3981383 to p 29%

(AF250878) orf; hypothetical protein [Salmonella

3981805 typhi] #N/A

Contig9 from

dbj |BAB0623S.l| (AP001515) transposase related SEQ ID n° 9349 PL-2279.1 3981762 to m 26% protein (20) [Bacillus halodurans] -

3982670 SEQ ID n~2443 ref |NP_042044.l| psu gène product (AA 1-190)

Contig9 from [Bacteriophage P4] sp | P05460 |VPSU_BPP4 POLARITY SEQ ID n° 9350 PL-4888.1 3983156 to m 57% SUPPRESSION PROTEIN (AMBER MUTATION-SUPPRESSING

3983518 PROTEIN) emb|CAA35906.l| (X51522) psu gène product (AA 1-190) [Bacteriophage P4] #N/A

Contig9 from gb |AAG58541. l |AE005567_2 (AE005567) putative DNA SΞQ ID n° 9351 PL-2280.1 3984034 to m 53% processing protein [Escherichia coli

3985455 0157 :H7] SEQ ID n~2445 pir| JT35189 probable ATP-dependent DNA helicase •

Streptomyces coelicolor emb|CAA18513. l|

(AL022374) SC5B8.05, probable ATP-dependent DNA

Contig9 from helicase, len:7 19 aa similar in N- SΞQ ID n° 9352 PL-2281.1 3985452 to 563 terminal half to many e.g. RECQ_ΞC0LIP1

3987554 5043 atp-dependent dna helicase recq (607 aa) , fasta score s,- opt: 546 z-score:

615.9 Ξ() : 4.1e-27, 35.9% identity in

362 aa ov> SEQ ID n~2446

Contig9 from gb|AAK00458.l| (AF200692) unknown [Shigella SΞQ ID n° 9353 PL-2282.1 3987722 to flexneri 2a]

3991036 SEQ ID n~2447 sp|P1503l|FECE_ECOLI IRO (III) DICITRATE

TRANSPORT ATP-BINDING PROTEIN FECE pir| | QRECM3 membrane-bound iron(III) dicitrate transport

Contig9 from protein - Escherichia coli SEQ ID n° 9354 PL-2283.1 3S91562 to m 823 gb|AAA23765.l| (M26397) fecE [Escherichia coli]

3992329 gb|AAAS7183.l| (U14003) fecE [Escherichia coli] gb|AAC77243.l| (AΞ000499) ATP-binding component of citrate-dependent iron (III) transport protein [Ξscherichia coli K12] SΞQ ID n~2448

sp|P15029|FΞCD_ECOLI IRON (III) DICITRATE

TRANSPORT SYSTEM PΞRMΞASE PROTEIN FΞCD pir||S56513 citraterdependent iron transport protein fecD - Ξscherichia coli pir||QRΞCD2

Contig9 from iron (III) dicitrate transport protein 2,

SEQ ID n° 9355 PL-2284.1 3992330 to 60* cytosolic - Ξschejrichia coli 3993286— gb|AAA97184.l| (U14003) CG Site No. 18394

[Ξscherichia coli] gb | AAC77244.l| (AE000499) citrate-dependent iron transport, membrane-bound protein [Escherichia coli K12] SΞQ ID n-2449

Sp | P15030 | FΞCC_ECOLI IRO (III) DICITRATE

TRANSPORT SYSTEM PERMΞASE PROTEIN FECC pir| |S56514 fecC protein - Escherichia coli

Contig9 from pir| |QRECDi iron (III) dicitrate transport SEQ ID n° 9356 PL-2285.1 3993283 to m 83? protein 1, cytosolic - Escherichia

3994281 coli gblAAA97185.l| (U14003) fecC [Ξscherichia coli] gb|AAC77245.l| (AE000499) citrate- dependent iro (III) transport protein, cytosolic

[Escherichia coli K12] SEQ ID n~2450

Contig9 from sp|P15028|FECB_ECOLI IRO (III) DICITRATΞ-BINDING SEQ ID n° 9357 PL-2286.1 3994278 to 82? PΞRIPLASMIC PROTEIN PRECURSOR

3995186 SΞQ ID n~1451 sp|P13036|FECA_ECOLI IRO (III) DICITRATE TRANSPORT PROTEIN FECA PRECURSOR pir| | QRECFA iro (III) dicitrate transport System outer

Contig9 from membrane receptor precursor - SEQ ID n° 9358 PL-2287.1 3995246 to 893 Escherichia coli (strain K-12) gb| AAC77247.1]

3997606 (AE000499) outer membrane receptor; citrate- dependent iron transport, outer membrane receptor [Ξscherichia coli K12] SΞQ ID n~2452

SΞQ ID n° 9359 PL-2288.1

SEQ ID n° 9360 PL-3274.1

polymerase sigma factor [Escherichia coli

K12] SΞQ ID n~2521

Contig9 from SEQ ID n° 9361 PL-4896.1 4001628 to No Hits found

4001792 #N/A ref |NP_073225.l| ransposase of IS630 [Salmonella enterica serovar Choleraesuis] dbj |BAA01531.l|

ContigS from

(D10689) M5 protein [Salmonella choleraesuis] SEQ ID n° 9362 PL-2289.1 4002228 to 72% dbj |BAB20556.l| (AB040415) ransposase of IS630

4003241

[Salmonella enterica serovar

Choleraesuis] SΞQ ID n-H.454

Contig9 from SEQ ID n° 9363 PL-4899.1 4004161 to No Hits found

4004436 #N/A Contig9 from gb|AAG55972.l|AE005330_4 (AΞ005330) putative SEQ ID n° 9364 PL-4902.1 4005243 to 66% holin protein of prophage CP-933X [Ξscherichia

4005569 coli 0157:H7] #N/A Contig9 from dbj |BAB06239.1 | (AP001515) transposase related SEQ ID n° 9365 PL-2290.1 4006115 to 21% protein (20) [Bacillus halodurans]

4007140 SΞQ ID n~2456 Contig9 from SΞQ ID n° 9366 PL-3275.1 4007482 to No Hits found

4007916 SΞQ ID n~2522

Contig9 from gb|AAC63217.l| (AF039135) juvénile hormone SΞQ ID n° 9367 PL-2291.1 4007955 to 53% esterase-related protein [Leptinotarsa

4009208 decemlineata] SEQ ID n~1457 Contig9 from SEQ ID n° 9368 PL-4907.1 4

Contig9 from gb|AAG60892.l|AF322013_ll (AF322013) ID459 SEQ ID n° 9369 PL-3276.1 4009726 to 413 [Bradyrhizobium japonicum]

4010271 SEQ ID n~2523 Contig9 from gb|AAC82519.l| (AF027768) RetA [Serratia SΞQ ID n° 9370 PL-4909.1 4010183 to 293 marcescens]

4010407 #N/A Contig9 from SEQ ID n° 9371 PL-4910.1 4010500 to No Hits found

4010706 #N/A pir| |C83234 hypothetical protein PA3290

ContigS from [imported] - Pseudomonas aeruginosa SEQ ID n° 9372 PL-22S2.1 4010636 to 153 (strain PAOl) gb|AAG06678.1 | Ξ004751_4

40121S8 (AΞ004751) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~2 58 pir] |G83403 conserved hypothetical protein

Contig9 from PA1938 [imported] - Pseudomonas SEQ ID n° 9373 PL-4916.1 4012623 to m 83% aeruginosa (strain PAOl)

4012745 gb|AAG05326.l|AΞ004620_5 (AE004620) conserved hypothetical protein [Pseudomonas aeruginosa] #N/A pir] |G83403 conserved hypothetical protein

PA1S38 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 9374 PL-4917.1 4012810 to 603 gb|AAG05326.l|AΞ004620_5 (AΞ004620) conserved

4013010 hypothetical protein [Pseudomonas aeruginosa] #N/A

Contig9 from SΞQ ID n° 9375 PL-4919.1 4013177 to m No Hits found

4013401 #N/A

Contig9 from SΞQ ID n° 9376 PL-4920.1 4013895 to m No Hits found

4014044 #N/A pir| |Ξ83174 hypothetical protein PA3775

Contig9 from [imported] - Pseudomonas aeruginosa

SΞQ ID n° 9377 PL-2293.1 4014172 to 663 (strain PAOl) gb| AAG07162.l| AE004796_7

4014924 (AΞ004796) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2459 pir| |G82983 probable MFS transporter PA5311

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 9378 PL-2294.1 4015033 to 533 (strain PAOl) gb|AAG08^"696. l| AΞ004943_12

4016229 (AΞ004943) probable MFS transporter [Pseudomonas aeruginosa] SEQ ID n~2460

Contig9 from gb|AAG58013.l|AΞ005518_7 (AΞ005518) Z4223 gène SΞQ ID n° 9379 PL-2295.1 4016587 to 87% product [Escherichia coli 0157 :H7]

4017957 SEQ ID n~2461 sp | P32703 | YJCE_ΞCOLI PUTATIVE NA(+) /H (+)

ΞXCHANGER YJCΞ pir||H65214 hypothetical 60.5 kD

Contig9 from protein in soxR-acs intergenic région - SEQ ID n° 9380 PL-2296.1 4018230 to 843 Escherichia coli (strain K-12) gb| AAC43159.l|

4019879 (U00006) similar to eukaryotic Na+/H+ exchangers

[Escherichia coli] gb|AAC77035.1 | (AE000480) orf, hypothetical protein [Ξscherichia coli K12] SΞQ ID n~2462

Contig9 from gb(AAA67624.l| (M87049) trans-activator of metE SEQ ID n° 9381 PL-2297.1 4020106 to m 83% and etH [Escherichia coli]

4021041 SEQ ID n~2463

sp|P25665|MΞTE_ECOLI 5-

METHYLTΞTRAHYDROPTΞROYLTRIGLUTAMATΞ--

HOMOCYSTEINE METHYLTRANSFERASE

(METHIONINE SYNTHASE, VITAMIN-B12

INDΞPENDENT ISOZYME) (COBALAMIN-INDEPENDENT

Contig9 from

METHIONINΞ SYNTHASE) pir||A42863 5- SEQ ID n° 9382-PL-2298.1 4021150 to 87% methyltetrahydropteroyltriglutamate--

4023426 homocysteine S-methyltransferase (ΞC

2.1.1.14) - Ξscherichia coli (strain

K-12) gb|AAC76832.l| (AE000458) tetrahydropteroyltriglutamate methyTtfansferase

[Ξscherichia coli K12] SEQ ID n~£464

Contig9 from pir| |T36711 probable dioxygenase - Streptomyces SEQ ID n° 9383 PL-2299.1 4023669 to 19% coelicolor emb|CAB45209. l| (AL079308) putative

4024502 dioxygenase [Streptomyces coelicolor A3 (2) ] SEQ ID n~2465 sp ] P28618 | CP_BACΞU PYRROLIDONE-CARBOXYLATE

PEPTIDASE (5-OXOPROLYL-PEPTIDASE)

(PYROGLUTAMYL-PEPTIDASE I) (PGP-I) (PYRASE) pir] ]S23432 pyroglutamyl-peptidase I (EC

Contig9 from

3.4.19.3) pep - Bacillus subtilis SΞQ ID n° 9384 PL-2300.1 4024747 to m 61% emb|CAA46833.l| (X66034) TRANSFERRED ΞNTRY:

4025403

3.4.19.3 [Bacillus subtilis] dbj |BAA06485.1 |

(D30808) pyrrolidone carboxy-peptidase [Bacillus subtilis] emb|CAB12059.l| (Z99105) pyrrolidone- carboxylate peptidase [Bacillus subtilis] SEQ ID n~ï468

Contig9 from emb| CAB94934.l| (AJ278525) uridine phosphorylase

SΞQ ID n° 9385 PL-2301.1 4026254 to p 89% [Yersinia pseudotuberculosis]

4027009 SΞQ ID n~2469

Contig9 from db^ |BAA81645.l| (AB028630) protein-tyrosine

SEQ ID n° 9386 PL-2302.1 4027104 to p 52% phosphatase [Clostridium perfringens]

4027886 SEQ ID n~£470

Contig9 from gb|AAG54369.l[AE005183_6 (AE005183) orf,

SEQ ID n° 9387 PL-2303.1 4028025 to P 413 hypothetical protein [Escherichia coli 0157 :H7]

4028615 SEQ ID n~2471

ContigS from gb|AAF33423.l| (AF233324) 88% identity to E. SΞQ ID n° 9388 PL-2304.1 4028721 to 77% coli hypothetical protein (YIGN)

SEQ ID n° 9389 PL-2305

sp|P27852 |YIGP_ECOLI HYPOTHETICAL 22.2 KD

PROTEIN IN UBIΞ-RFAH INTERGENIC REGION

Contig9 from pir| |C65188 hypothetical 22.3 kD protein in udp- SEQ ID n° 9390-PL-2306.1 4030921 to 623 rfaH inte^"rgenic région - Ξscherichia

4031556 coli (strain K-12) gb|AAC76837.l| (AE000459) orf, hypothetical protein [Ξscherichia coli K12] SΞQ ID n~2474 sp | 007443 |AARF_PR0ST UBIQUINONE BIOSYNTHΞSIS

PROTΞIN AARF (AMINOGLYCOSIDE

ACETYLTRANSFERASE REGULATOR) pir| |T51162

Contig9 from aminoglycoside acetyltransferase regulator SEQ ID n° 9391 PL-2307.1 4031543 to 903

[imported] - Providencia stuartii

4033180 gb|AAB36577.l| (AF002165) aminoglycoside acetyltransferase regulator [Providencia stuartii] SEQ ID n~2475 sp|P57045|TATA_SALTY SEC-INDEPENDENT PROTEIN

TRANSLOCASE PROTEIN TATA gb] AAF33419.1 |

Contig9 from

(AF233324) 83% identity with amino acids 10-79

SEQ ID n° 9392 PL-4925.1 4033407 to 783 of E. coli hypothetical protein (YIGT)

4033667

(SP:P27856) [Salmonella typhimurium

LT2] #N/A sp| 069415 |TATB_ECOLI SEC-INDEPENDENT PROTEIN

Contig9 from TRANSLOCASE PROTEIN TATB emb | CAA06725.1 | SEQ ID n° 9393 PL-4926.1 4033671 to p 723 (AJ005830) TatB protein [Escherichia coli]

4034114 gb|AAC19241.l| (AF067848) MttA2 [Escherichia coli] #N/A

gb|AAF33418.l| (AF233324) 90% identity to E.

SEQ—ID-n° 9394 PL-2308.-1

SΞQ ID n° S395 PL-2309.1 4035028 to p 853 cholerae (group 01 strain N16961)

4036041 gb|AAF93283.l| (AE004101) delta-aminolevulinic acid dehydrata^~se^~~[Vibrio cholerae] SEQ ID n~2477^~

Contig9 from gb|AAF33417.l| (AF233324) 88% identity to E. SΞQ ID n° 9396 PL-3278.1 4036091 to 793 coli transcriptional activator RFAH)

4036579 (SW:P26614) [Salmonella typhimurium LT2] SEQ ID n~2525 Contig9 from gb|AAF33412.l| (AF233324) 92% identity to E. SEQ ID n° 9397 PL-2310.1 4037197 to 92% coli hyopthetical protein (YIGC)

4038678 (SW:P26615) [Salmonella typhimurium LT2] SEQ ID n~2479 sp | P43129 | FRE_PHOLU NAD (P) H-FLAVIN REDUCTASE

Contig9 from

(NAD(P)H:FLAVIN OXIDOREDUCTASE) dbj |BAA04597.1 | SEQ ID n° 9398 PL-2311.1 4038689 to 933

(D17745) NAD(P)H-flavin reductase, Fre

4039390

[Photorhabdus luminescens] SEQ ID n~2480

ContigS from gb|AAG59039.l|AE005615_7 (AΞ005615) thiolase I; SEQ ID n° 9399 PL-2312.1 4039474 to 823 3-ketoacyl-CoA thiolase; acetyl-CoA

4040640 transferase [Ξscherichia coli 0157 :H7] SEQ ID n~2481

sp|P21177|FADB_ΞCOLI FATTY OXIDATION COMPLEX ALPHA SUBUNIT [INCLUDES: ENOYL-COA HYDRATASE ; DELTA(3) -CIS-DΞLTA(2) -TRANS-ENOYL-

COA ISOMERASE^{" ~} 3 -HYDROXYACYL-COA

DEHYDROGENASE 3 -HYDROXYBUTYRYL-COA

ΞPIMΞRASΞ ] pir| | A39592 fatty acid beta oxidation compÏ x^""alpha^""chain - Bschexicfiia coïT^"

Contig9 from gb|AAA62777.l| (M74164) 73 -kDa multifunctional SΞQ ID n° 9400 PL-3149.2 4040652 to m 83^! protein [Escherichia coli] gb| AAA67643. l|

4042838 (M8704S) large (alpha) subunit of the fatty acid- oxidizing multienzyme^"complex

[Escherichia coli] gb|AAC7684S.l| (AE000460) 4- enzyme protein: 3-hydroxyacyl-CoA dehydrogenase;

3 -hydroxybutyryl-CoA epimerase; delta(3) -cis-delta (2) -trans-enoyl-CoA isomerase; enoyl-CoA hydratase [Escherichia coli K12] SEQ ID n~2394 sp|P21165|PEPQ_ΞCOLI XAA-PRO DIPEPTIDASE (X-PRO

DIPEPTIDASE) (PROLINE DIPEPTIDASΞ)

Contig9 from

(PROLIDASΞ) (IMIDODIPΞPTIDASE) pir| |H65183 X- SEQ ID n° 9401 PL-3148.1 4043112 to P 83% ..

Pro dipeptidase (EC 3.4.13.3) - Ξscherichia coli

4044446

(strain K-12) gb |AAC76850.1 | (AE000460) proline dipeptidase [Escherichia coli K12] SΞQ ID n~ 393

Contig9 from gb|AAG5S042.l|AE005615_10 (AΞ005615) orf, SEQ ID n° 9402 PL-3147.1 4044446 to 73% hypothetical protein [Escherichia coli 0157 :H7]

4045057 SEQ ID n~2392 sp]P21166|TRKH_ECOLI TRK SYSTEM POTASSIUM UPTAKE

PROTEIN TRKH pir| |A5615l trkH protein

Contig9 from

(corrected) - Escherichia coli SΞQ ID n° 9403 PL-3146.1 4045095 to 92% gb|AAG53043.l|AΞ005615_ll (AE005615) potassium

4046546 uptake protein, reguires TrkE [Escherichia coli 0157 :H7] SEQ ID n~2391

Contig9 from SΞQ ID n° 9404 PL-3279.1 4046570 to p 673 gb|AAA67647.l| (M8704S) ol81 [Escherichia coli]

4047106 SEQ ID n~2526

Contig9 from gb|AAG59205.l|AE005633_2 (AΞ005633) homoserine SEQ ID n° 9405 PL-2853.1 4053768- to P 86% transsuccinylase^"" [Escherichia coli 0157 :H7]

4054697 _SΞQ ID n~2067

Sp|P08997|MASY_ECOLI MALATE SYNTHASΞ A (MSA) pιr| |SYECMA malate synthase (ΞC 4.1.3.2) A -

ContigS from Ξscherichia coli emb| CAA30973 ,l| (X12431)

SEQ ID n° 9406 PL-2854.1 4054997 to 87% ~maïâte synthase [Ξscherichia coli]

4056595 gb|AAC43108.l| (U00006) malate synthase A

[Ξscherichia coli] gb |AAC76984.1 | (AΞ000474) malate synthase A [Escherichia coli K12] SEQ ID n~2068

^~~ sp | P053^"13^""|ACΞA_ECOLI ISOCITRATE LYASE

(ISOCITRASE) (ISOCITRATASE) (ICL) pir| |WZECIC isocitrate lyase (EC 4.1.3.1) - Escherichia coli

Contig9 from emb]CAA30974.1| (X12431) isocitrate lyase SEQ ID n° 9407 PL-2855.1 4056632 to 90%

[Escherichia coli] g | AAC43109.1 | (U00006)

4057999 isocitrate lyase [Escherichia coli] gb|AAC76985.l| (AE000474) isocitrate lyase

[Escherichia coli K12] SEQ ID n~2069 gb|AAC43891.l| (U43356) isocitrate dehydrogenase

Contig9 from kinase/phosphatase [Salmonella SEQ ID n° 9408 PL-2856.1 4058051 to 81% enterica] gb|AAC43893.l| (U43357) isocitrate

405S808 dehydrogenase kinase/phosphatase [Salmonella enterica] SEQ ID n~2070

ContigS from SEQ ID n° 9403 PL-2857.1 4060230 to No Hits found

4060796 SEQ ID n~2071 pir| |RPΞCIR acétate operon repressor -

Escherichia coli gb|AAA50561.l| (M63914) repressor of the aceBAK operon [Escherichia

ContigS from coli] gb]AAC43112.l| (U00006) CG Site No. 614 SEQ ID n° 3410 PL-2858.1 4061088 to m 82%

[Escherichia coli] gb|AAC76988. l| (AE000475)

4061318 repressor of aceBA operon [Escherichia coli K12] gb|AAG59210.l|AE005633_7 (AE005633) repressor of aceBA operon [Escherichia coli 0157 :H7] SEQ ID n~2072

Contig9 from gb|AAF57570.l| (AE003796) CG10073 gène product _SEQ_ID n° 9411 PL-2859.1 4062683 to 34J [Drosophila mëlànogas^"ter]^""

4064182 SEQ ID n~ 073 pir| |H83490 hypothetical protein PA1239

Contig9 from [imported] - Pseudomonas aeruginosa

SEQ ID n° 9412 PL-2860.1 4064984 to p 34% (strain PAOl) gb| AG04628.l| AΞ004553_5 " ^" 4065820 ===== (AΞ00:553 ) ^" hypothetical protein—[Pseudomonas aeruginosa] SBQ ID n~2075

Contig9 from emb|CAB99168.l] (AL390188) putative intégral SEQ ID n° 9413 PL-4963.1 4065813 to p 46% membrane protein [Streptomyces ^{~ "} 4066196 coelicolor A3^~"(2)^""] #N/A

Contig9 from SEQ ID n° 9414 PL-2861.1 4066244 to No Hits found

4067140 SEQ ID n~2076 Contig9 from gb|AAC44790.l| (U76606) isobutylamine N- SEQ ID n° 9415 PL-2862.1 4067189 to p 313 hydroxylase [Streptomyces viridifaciens]

4068235 SEQ ID n~2077 sp | 066442 | ARGD_AQUAΞ ACΞTYLORNITHINΞ

AMINOTRANSFΞRASΞ (ACOAT) pir | [G70301 N-

Contig9 from acetylornithine aminotransferase - Aquifex SΞQ ID n° 9416 PL-2863.1 4068328 to p 183 aeolicus gb|AAC063S0.l| (AΞ00066S) N-

4070895 acetylornithine aminotransferase [Aguάfex aeolicus] SBQ ID n~2078

Contig9 from emb | CAB99l67 . l | (AL390188 ) hypothetical protein SEQ ID n° 9417 PL-2864.1 4070879 to p 453 2SCG18 .34c [Streptomyces coelicolor

4071916 A3 (2 ) ] SBQ ID n~2079 Contig9 from gb|AAD01342.l| (AF032440) D-alanine-D-alanyl SEQ ID n° 9418 PL-2865.1 4072124 to m 533 carrier protein ligase; DltA

4073587 [Staphylococcus xylosus] SEQ ID n~2080 sp|P33580|DLTB_BACSU DLTB PROTBIN pir||S39659

ContigS from dltB protein - Bacillus subtilis SEQ ID n° 9419 PL-2866.1 4073584 to m 48% emb|CAA51560.l| (X73124) ipa-4r [Bacillus

4074708 subtilis] emb|CAB15877.l| (Z99123) alternate gène name: ipa-4r [Bacillus subtilis] SEQ ID n~2081

Contig9 from emb|CAB51922.l| (AJ012255) extramembranal SΞQ ID n° 9420 PL-2867.1 4074852 to m 43% protein [Listeria monocytogenes]

4076054 SEQ ID n~2082 sp|P39579|DLTC_BACSU D-ALANYL CARRIER PROTEIN

(DCP) pir| |S39658 D-alanine carrier protein dite - Bacillus subtilis emb| CAA5l559.l|

.Contig9 from

^~(X73124F ipa-3r^~[Bacillus subtilis]

SΞQ ID n° 9421 PL-4964.1 4076051 to 433 gb|AAB34706. l| D-alanyl carrier protein, 4076362 Dcp=dltC product [Bacillus subtilis, Peptide, 78 aa] emb|CAB15878.l| (Z99123) D- alanyl ^"""carrier protein (Dcp) [Bacillus subtiïis]^""" #N/A

Contig9 from gb|AAG59223.l|AΞ005635_3 (AE005635) SΞQ ID n° 9422 PL-2868.1 4077253 to m 80% aspartokinase III, lysine sensitive [Ξseherichia

4078632 coli 0157.-H7] SEQ ID n~2083 ContigS from sp | P11243 | G6PI_CLAUN GLUCOSE-6 -PHOSPHATΞ SΞQ ID n° 9423 PL-2869.1 4078931 to 873 ISOMERASE, CHLOROPLAST (GPI) (PHOSPHOGLUCOSE

4080577 ISOMERASE) (PGI) (PHOSPHOHEXOSE ISOMERASE) . (PHI) SΞQ ID n~2084 Contig9 from gb|AAG59238.l|AE005637_2 (AE005637) Chorismate SΞQ ID n° 9424 PL-3280.1 4080879 to 57% lyase [Escherichia coli 0157 :H7]

4081397 SEQ ID n~2528 sp [ 052366 | UBIA_PROST 4-HYDROXYBENZOATE

OCTAPRENYLTRANSFERASΞ (4-HB

Contig9 from

POLYPRBNYLTRANSFERASE) gb | AAB88868.11 SEQ ID n° 9425 PL-2870.1 4081420 to p 84%

(AF036909) 4-hydroxybenzoate

4082286 octaprenyltransferase [Providencia stuartii] SEQ ID n~2086 pir| |XUECAG glycerol-3 -phosphate 0-

Contig9 from acyltransferase (EC 2.3.1.15) - Escherichia SEQ ID n° 9426 PL-2871.1 4082330 to m 843 coli gb|AAC77011.l| (AE000477) glycerol-3-

4084786 phosphate acyltransferase [Ξscherichia coli

K12] SEQ ID n~2087

sp|P00556|KDGL_ΞCOLI DIACYLGLYCΞROL KINASΞ

(DAGK) (DIGLYCΞRIDΞ KINASΞ) (DGK) pir| | KIECDG probable diacylglycerol kinase (ΞC 2.7.1.107) -

Ξscherichia coli gb |AAC43136.1 | (U00006)

Contig9 from diacylglycerol kinase [Ξscherichia coli]

SΞQ ID n° 9427 PL-4966.1 4084916 to 793 gb|AAA2 394.l| (KO0127) diglyceride kinase — - -408:5≤-8τ=-=-

[Ξschérichia^"coIîT ~ gb | AAC77012 . 11 (AΞ000477) diacylglycerol kinase [Escherichia coli K12] gb|AAG59241.l|AΞ005637_5 (AΞ005637) diacylglycerol kinase [Ξscherichia coli 0157 :H7] #N/A sp|Q07267|LΞXA_PRORΞ LΞXA RΞPRΞSSOR pir||S33693

Contig9 from lexA protein - Providencia rettgeri SΞQ ID n° 9428 PL-2872.1 4085407 to 903 emb]CAA50300.l| (X70965) LexA repressor

4086012

[Providencia rettgeri] SEQ ID n~2088 pir| |E65212 hypothetical 21.7 kD protein in dinF

ContigS from qor intergenic région - Escherichia

SΞQ ID n° 9429 PL-3281.1 4086172 to m 73% coli (strain-K-12) -gb| AAC77016.l| (AΞ000478)

4086684 putative regulator [Ξscherichia coli K12] SΞQ ID n~2529

ContigS from sp|P76228|YNJI_ECOLI HYPOTHETICAL 40.3 KDA

SEQ ID n° 9430 PL-2873.1 4086904 to 39% PROTEIN IN GDHA-TOPB INTERGENIC REGION

4088046 SΞQ ID n~2089

Contig9 from pir |] 139549 Lactate oxidase - Aerococcus

SEQ ID n° 9431 PL-2874.1 4088374 to m 55% viridans dbj |BAA09172.l| (D50611) lactate

4089462 oxidase [Aerococcus viridans] SΞQ ID n~2090

Contig9 from gb|AAG54576.l|AΞ005203_5 (AΞ005203) unknown

SEQ ID n° 9432 PL-2875.1 4090064 to 17% protein from prophage CP-933H [Escherichia

4090900 coli 0157-.H7] SEQ ID n~2091 ref ]NP_050998.l| P37 [Bacteriophage APSΞ-1]

Contig9 from sp | Q9T1R1 | TFA_BPAPS PROBABLΞ TAIL FIBBR ASSEMBLY

SEQ ID n° 3433 PL-3282.1 4090879 to 623

PROTEIN (P37) g ] AAF03980.1 | AF157835_37

4091328

(AF157835) P37 [Bacteriophage APSE-1] SEQ ID n~2530

Contig9 from

SEQ ID n° 9434 PL-2876.1 4091483 to No Hits found

4092073 SEQ ID n~2092

sp | P37668 | YIAG_ECOLI HYPOTHETICAL 11.0 KD - PROTEIN IN BISC-CSPA INTERGΞNIC REGION—(096) pir| |S47776 hypothetical 11K protein (bisC-cspA

Contig9 from intergenic région) - Escherichia coli SEQ ID n° S435 PL-4968.1 4092276 to p 46% gb|AAB18532.l| (U00039) No définition line found

4092572 [Ξscherichia coli] gb | AAC76579. l| (AE000433) orf, hypothetical protein [Eschenchia cc5li K12] gb|AAG58704.l|AΞ005582_7 (AE005582) orf, hypothetical protein [Escherichia coli 0157 :H7] #N/A ref (NP_046945. I| gp49 [Bacteriophage N15]

Contig9 from pir| |τi3l36 protein gp^"4S^" - phage Ni5

SEQ ID n° 9436 PL-4S71.1 40S28S7 to p 63% gb|AAClS088.l| (AF06453S) gp49 [Bacteriophage

40S3016

N15] #N/A ref |NP_046944.l| gp48 [Bacteriophage N15]

ContigS from pir| |T13135 protein gp48 - phage N15 SEQ ID n° 9437 PL-4372.1 4033013 to p 78% gb|AAC19087.l| (AF064539) gp48 [Bacteriophage

4093297

NI5] #N/A pir] |H65212 hypothetical 38.4 kD protein in dinF

Contig9 from qor intergenic région - Bscherichia SEQ ID n° 9438 PL-2877.1 4093714 to p 81% coli (strain K-12) gb|AAC77013.1 | (AE000478)

4094751 orf, hypothetical protein [Escherichia coli K12] SEQ ID n~20S3 ref |NP_071813.1 | unknown [Methanothermobacter

Contig9 from wolfeii prophage psiMIOO] SΞQ ID n° 9439 PL-4973.1 4095332 to p 41% gb|AAG39352.l|AF301375_12 (AF301375) unknown

4095778 [Methanothermobacter wolfeii prophage psiMIOO] #N/A

Contig9 from dbj |BAB06239.l| (AP001515) transposase related SEQ ID n° 9440 PL-2878.1 4095828 to p 21% protein (20) [Bacillus halodurans]

4096853 SEQ ID n~2094 ref | NP_071814.1 | unknown [Methanothermobacter

Contig9 from wolfeii prophage psiMIOO] SEQ ID n° 9441 PL-4975.1 4097470 to p 60% gb|AAG39953.l|AF301375_13 (AF301375) unknown

4097847

[Methanothermobacter wolfeii prophage psiMIOO] #N/A

Contig9 from gb|AAG59249.l]AE005638_3 (AΞ005638) quinone SEQ ID n° 9442 PL-2880.1 4098058 to m 83% oxidoreductase [Escherichia coli 0157 :H7]

4099041 SEQ ID n~2097

ContigS from

SEQ ID n° 3443 PL-2881.1 403.9212 to p 89% sp[P10338|DNAB__SALTY REPLICATIVΞ DNA HΞLICASE

4100621 SΞQ ID n~2098 sp|P29743|ALRl_ΞCOLI ALANINΞ RACEMASE,

Contig9 from BIOSYNTHETIC pir||PC1296 alanine racemase (EC

SEQ ID n° 9444 PL-2882.1 4100661 to 783 5.1.1.1), biosynthetic - Escherichia coli

4101740 (^"straih^~I-^"i2^"P gb [AAC77^~023. l] (ÀE000478) alanine^" racemase 1 [Escherichia coli K12] SΞQ ID n~2099 sp|P04693 |TYRB_ECOLI AROMATIC-AMINO-ACID

AMINOTRANSFERASE (AROAT) (ARAT) pir| |XNECY

^{^}ârômât^"îc^"-amino-acid transaminase (ΞC 2.6.1.57) tyrB [validated] - Ξscherichia coli pdb|3TAT]A Chain A, Tyrosine Aminotransferase

From Ξ. Coli pdb|3TAT|B Chain B, Tyrosine

Aminotransferase From E . Coli pdb | 3TAT | C Chain

C, Tyrosine Aminotransferase From E. Coli pdb_|3TAT|D Chain D, Tyrosine Aminotransferase .

Contig9 from From Ξ. Coli pdb|3TAT|Ξ Chain Ξ, Tyrosine SEQ ID n° 9445 PL-2883.1 4101790 to 81? Aminotransferase From E. Coli pdb|3TAT|F Chain

4102989 F, Tyrosine Aminotransferase From E. Coli gb]AAA24703.l| (M12047) tyrosine aminotransferase [Escherichia coli] gb|AAC43148.l| (U00006) tyrosine aminotransferase [Escherichia coli] emb|CAA27278.l| (X03628) aromatic aminotransferase (tyrB) [Escherichia coli] gb|AAC77024.l| (AE000478) tyrosine aminotransferase, tyrosine repressible

[Escherichia coli K12] SΞQ ID n~2100 ref |NP_073225. l| ransposase of IS630 [Salmonella enterica serovar Choleraesuis] dbj |BAA01531.1 |

Contig9 from

(D10689) M5 protein [Salmonella choleraesuis] SEQ ID n° 9446 PL-2884.1 4103382 to 723 dbj |BAB20556.l| (AB040415) ransposase of IΞ630

4104395

[Salmonella enterica serovar

Choleraesuis] SΞQ ID n~ 101

ContigS from pir| |S49177 colicin Ξ4 immunity protein - _j_E_Q__ID n° S447 PL-4376.1 4104444 to .803 Escherichia coli plasmid ColΞ4 emb(CAA45168.1 |

4104698 (X63621) immunity protein [Escherichia coli] m/A

Contig9 from gb|AAG56337.l|AΞ005362_7 (AE005362) orf, SEQ ID n° 9448 PL-3284.1 4104770 to m 59%

hypothetical protein [Escherichia coli 0157 :H7]

4105189 SEQ ID n~2532

ContigS froπr SEQ ID n° 9449 PL-7102.1 4105229 to m No Hits found

4105405 #N/A Contig9 from gb|AAG57304.1JAΞ005449_2 (AΞ005449) putative SEQ ID n° 9450 PL-2885.1 4106094 ^"to— 583 kinase [Escherichia coli 0157:H7]

4107179 SΞQ ID n~2102 Contig9 from gb|AAG57303.l|AΞ005449_l (AΞ005449) orf, SEQ ID n° 9451 PL-2886.1 4107182 to 79% hypothetical protein [Ξscherichia coli 0157 :H7]

4108120 SEQ ID n~2103 ContigS from sp|P37434|UVRA_SALTY ΞXCINUCLΞASΞ ABC SUBUNIT A SΞQ ID n° 9452 PL-2887.1 4108181 to 943 gb|AAA27250.l| (M93014) DNA repair enzyme

4111015 [Salmonella typhimurium] SEQ ID n~2104 sp|P25762|SSB_SERMA SINGLE-STRAND BINDING

PROTEIN (SSB) (HELIX-DESTABILIZING PROTEIN)

Contig9 from pir| | N0632 single-stranded DNA-binding protein SEQ ID n° 9453 PL-2888.1 4111374 to 74%

Serratia marcescens emb|CAA46208.1 | (X65080)

4111910 single-stranded DNA-binding protein [Serratia marcescens] SEQ ID n~2105 ref ]NP_049098.l| GroupII intron-associated maturase [Sphingomonas aromaticivorans]

Contig9 from pir| |T31170 maturase-related protein (group II SEQ ID n° 9454 PL-4980.1 4112274 to 503 intron) - Sphingomonas

4112462 aromaticivorans plasmid pNLl gb| AD03894.1 |

(AF079317) GroupII intron-associated maturase

[Sphingomonas aromaticivorans] #N/A

ContigS from emb|CAB46587.l| (AJ132945) hypothetical protein SΞQ ID n° 9455 PL-2889.1 4112824 to p 42% [Yersinia enterocolitica]

4113906 SEQ ID n~2106

Contig9 from SΞQ ID n° 9456 PL---2890.1 4113941 to No Hits found

_ _ 4114873 _ SΞQ ID n~2108

Contig9 from SEQ ID n° 9457 PL-3285.1 4115212 to No Hits found

4115772 SΞQ ID n~2533

^{"" "} Contig9 from emb|CAA71688.l| (Y10687) purine NTPase SEQ ID n° 3458 PL-416.2 4115773 to 403 [Sulfolobus acidocaldarius]

4118931 SEQ ID n~3222 ContigS from sp|P21683 |CRTB_PANAN PHYTOΞNΞ SYNTHASΞ

SEQ ID n° 3459 PL-415.1 4119695 to 633 pir| ]E37802 crtB protein - Erwinia uredovora

4120621 dbj |BAA14128.l| (D30087) crtB [Pantoea ananas] SΞQ ID n~S221 sp|P21685|CRTI_PANAN PHYTOENE DEHYDROGENASE

Contig9 from (PHYTOENE DΞSATURASΞ) pir] |D37802 phytoene SEQ ID n° 9460 PL-414.1 4120618 to 82% dehydrogenase (EC 1.3.-.-) crtl - Erwinia

4122099 uredovora dbj |BAA141 7.l| (DS0087) crtl

[Pantoea ananas] — - SEQ ID n~3220

ContigS from pir] [S52585 dycopene cyclase - Brwinia herbicola SEQ ID n° 9461 PL-413.1 4122092 to 633 gb|AAA21262. ι| (MS0638) dycopene cyclase

4123267 [Ξrwinia herbicola] SEQ ID n~321S sp|Q01335]YCR6_ΞRWHE HYPOTHETICAL 37.2 KD

PROTΞIN IN CRTE-CRTX INTΞRGΞNIC REGION (0RF6)

Contig9 from pir||S5237S hypothetical protein 6 - Ξrwinia SEQ ID n° 9462 PL-412.1 4123381 to 69% herbicola gb|AAA64S78.1 j (M87280) gène not

4124037 found in Ξrwinia uredovora crt gène cluster,-

0RF6 [Erwinia herbicola] SEQ ID n~3218

Contig9 from gb|AAC26596.l| (U83995) putative protease SEQ ID n° 9463 PL-411.1 4124089 to 59% [Porphyromonas gingivalis]

4124973 SΞQ ID n~3217 sp | Q01335 | YCR6_ERWHE HYPOTHETICAL 37.2 KD

PROTEIN IN CRTE-CRTX INTΞRGΞNIC REGION (0RF6)

Contig9 from pir| |S52979 hypothetical protein 6 - Ξrwinia SEQ ID n° 9464 PL-3286.1 4124986 to 61% herbicola gb|AAA64978. l| (M87280) gène not

4125408 found in Ξrwinia uredovora crt gène cluster,-

ORF6 [Ξrwinia herbicola] SEQ ID n~2534

sp|P21684[CRTE_PANAN GΞRANYLGΞRANYL

Contig9 from- PYROPHOSPHATΞ SYNTHETASE (GGPP SYNTHETASE) SEQ ID n° 9465 PL-410.1 4125431 to 553 (FARNΞSYLTRANSTRANSFΞRASΞ) pi | | A37802 crtΞ

4126333 protein - Ξrwinia uredovora dbj |BAA14124.l|

(D90087) crtE [Pantoea ananas] SEQ ID n~3216

pir| |S76169 hypothetical protein - Synechocystis

-eont±g9—froπr sp. (Strain PCC 6803) ddbbjjl|BBAAAAÏ188442288..îlp| (D90914)

SEQ ID n° 9466 PL-409.1 4126568 to m 463 lignostilbene-alpha,beta-dioxygenase

4128040 [Synechocystis sp . ] SEQ ID n~3214

Contig9 from

SΞQ ID n° 9467 PL-4984.1 4128133 to m No Hits found

4128327 #N/A

Contig9 from

SEQ ID n" 9468 PL-4985.1 4128400 to No Hits found

4128729 #N/A

Contig9 from pir||S75249 esterase sllOSS2 - Synechocystis sp.

SEQ ID n° 9469 PL-408.1 —4-129641 to 70% (strain— CC 6803)- dbj (BAA17163.1 | (DS0904)

4130489 esterase [Synechocystis sp.] SEQ ID n~3213

Contig9 from gb|AAD46162.1 |AF130307_1 (AF130307) glutathione-

SEQ ID n° 9470 PL-407.1 4130612 to m 91% dependent formaldehyde dehydrogenase

4131721 [Acmetobacter baumannii] SEQ ID n~3 12

Contig3 from

SEQ ID n^» 9471 PL-4986.1 4132050 to m No Hits found

4132208 #N/A

Contig9 from

SEQ ID n° 9472 PL-4987.1 4132229 to m No Hits found

4132534 #N/A

Contig9 from

SEQ ID n° 9473 PL-4988.1 4132636 to No Hits found

4132893 #N/A pir| |B82317 hypothetical protein VC0492

Contig9 from

[imported] - Vibrio cholerae (group 01

SEQ ID n° 9474 PL-406.1 4133326 to 383 strain N16961) gb| AAF93665.1 | (AE004135)

4134534 hypothetical protein [Vibrio cholerae] SEQ ID n~3205

Contig9 from SEQ ID ni 9475 PL-3287.1 4134537 to No Hits found 4135019 SEQ ID n~2J535_

Contig9 from ref |NP_059777.1| yme [Agrobacterium tumefaciens]

SEQ ID n° 9476 PL-405.1 4135022 to 48% gb|AAB91579.2 | (AF242881) yme [Agrobacterium

4137007 tumefaciens] SEQ ID n~S195

Contig9 from gb]AAG59478.l|AE005659_13 (AE005659) Z5892 gène

SEQ ID n° 9477 PL-404.1 4137205 to 693 product [Escherichia coli 0157 :H7]

4138077 SEQ ID n~3188 pir| |T13261 hypothetical protein 536 -

Contig3 from

Lactococcus lactis phage BK5-T gb|ÂAÂ3858 .1 |

SEQ ID n° 9478 PL-403.2 4138907 to 543

(L445S3) 0RF536; putative [Lactococcus phage BK5

4140532

T] SEQ ID n~3179

Contig9 from gb|AAF22S61.l]AF157483_l (AF157489) Pin SΞQ ID n° 9479 PL-4990.1 4140747 to m 67% [Photorhabdus luminescens]

41408S9 #N/A sp|P10486|TlRl_ECOLI TYPE I RESTRICTION ENZYME

EC0R124II R PROTEIN (R.ECOR124II) pir||S02168

Contig9 from type I site-specific deoxyribonuclease (ΞC SEQ ID n° 9480 PL-402.1 4141304 to m 88% 3.1.21.3) ECOR124/3 chain hsdR -

4144420 Escherichia coli plasmid R124/3 emb|CAA31543. l|

(X13145) hsdR protein (AA 1-1033) [Escherichia coli] SEQ ID n~S171 pir| |H81152 anticodon nuclease NMB0832

Contig9 from

[imported] - Neisseria meningitidis SEQ ID n° 9481 PL-401.1 4144446 to 703

(group B strain MD58) gb|AAF41243. l] (AE002436)

4145600 anticodon nuclease [Neisseria meningitidis MC58] SEQ ID n~S160 pir] | 141084 type I site-specific

Contig9 from deoxyribonuclease (EC 3.1.21.3) EcoDXXI chain SEQ ID n° 9482 PL-400.1 4145602 to m 58% hsdS - Escherichia coli emb|CAA52162.l|

4146699

(X73984) hsdS [Escherichia coli] SEQ ID n~S156

sp|P10484]TlMl_ECOLI TYPΞ I RΞSTRICTION ΞNZYMΞ

ECOR124II_.M PROTΞIN (M.ECOR124II) pir|]S02166

Contig9 from type I site-specific deoxyribonuclease (EC

SΞQ ID n° 9483 PL-399.1 4146696 to m 913 3.1.21.3) EcoR124/3 chain hsdM - 4148252 Escherichia coli plasmid R124/3 emb |CAA31541.1 |

(X13145) hsdM protein (AA 1-520) [Ξscherichia

= coli] — ^"SΞQ ID n-3146

Contig9 from gb|AAG54584.1JAΞ005203_13 (AE005203) integrase

SEQ ID n° 9484 PL-4S92.1 4148577 to 583 protein for prophage CP-933I [Ξscherichia coli

4148876 0157:H7] #N/A gb^~|AAG54886.l|AΞ005234_2 (AE005234) 5,10-

Contig9 from methylene-tetrahydrofolate dehydrogenase ;

SEQ ID n° 9485 PL-398.1 4149168 to 823

5, 10-methylene-tetrahydrofolate cyclohydrolase

4150043

[Escherichia coli 0157 :H7] SEQ ID n~3138

Contig9 from gb|AAG54885.l|AE005234_l (AE005234) orf,

SEQ ID n° 9486 PL-4993.1 4150043 to 66% hypothetical protem [Escherichia coli 0157 :H7]

4150255 #N/A

Contig9 from gb|AAC26596.l| (U83995) putative protease

SEQ ID n° 9487 PL-397.1 4151036 to 59% [Porphyromonas gingivalis]

4151980 SEQ ID n~S128

Sp| P3929l|YJFI_ECOLI HYPOTHETICAL 14.9 KD

PROTEIN IN VACB-AIDB INTERGENIC REGION (0133A) pir| |S56406 hypothetical 14.9K protein b4181 -

Contig9 from Escherichia coli gb|AAA97077. l| (U14003) SEQ ID n° 9488 PL-4994.1 4152349 to 38% ORF_ol33a [Escherichia coli] gb| AAC77138.1 |

4152765 (AΞ000490) orf, hypothetical protein

[Ξscherichia coli K12] gb |AAG59377.1 | AΞO05651_6

(AE005651) orf, hypothetical protein

[Escherichia coli 0157 :H7] #N/A pir| |C83179 conserved hypothetical protein

Contig9 from PA3731 [imported] - Pseudomonas SEQ ID n° 9489 PL-396.1 4152786 to 593 aeruginosa (strain PAOl)

4153469 gb|AAG07118.l|AE004792_3 (AE004792) conserved hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~3118

sp|P39293 ]YJFK_ΞCOLI HYPOTHETICAL 25.0 KD

PROTEIN IN VACB-AIDB INTERGENIC REGION (0219)

Contig9 from pir|_Ls56408 hypothetical 25.0K protein (vacB-

SEQ ID n° 9490 PL-395.1 4153535 to 373 aidB intergenic région) - Escherichia 4154197 coli gb|AAA97079.l| (U14003) ORF_o219

[Escherichia coli] gb|AAC77l40.l| (AΞ000490)

^"orf, hyp theticâTTp o ëïή [Ξscherichia coli K12] SΞQ ID n~3107 sp | P3929 | JFL_ECOLI HYPOTHETICAL 1 .2 KD

PROTΞIN IN VACB-AIDB INTERGENIC REGION (0132) pir||S56409 hypothetical 14.2K protein (vacB-

Coritig -from^" aidB intergenicT^~rsgïon) ^~^^{" "} Ξscherichia

SΞQ ID n° 9491 PL-4995.1 4154198 to 553 coli gb|AAA97080.l| (U14003) 0RF_ol32

4154635 [Escherichia coli] gb[AAC77141.l | (AE000490) orf, hypothetical protein [Ξscherichia coli K12] gb|AAG59380.l|AE005651_9 (AE005651) yjfL gène product [Ξscherichia coli 0157 :H7] #N/A

Contig9Jroπi gb|AAG58176.l|AΞÔ0^"5533_9 (AΞ005533) orf,

SΞQ ID n° 9492 PL-393.1 4154648 to 263 hypothetical protein [Escherichia coli 0157:H7]

4155535 SΞQ ID n~3092 sp|P24196|YGIC_ECOLI HYPOTHETICAL 45.0 KD

PROTEIN IN TOLC-RIBB INTERGENIC REGION (ORFA)

(0386) pir| |S22361 hypothetical protein A -

Escherichia coli gb|AAA71876. l] (M77129) ORFA

Con ig9 from [Escherichia coli] gb| AAA69206.1] (U28377)

SΞQ ID n° 9493 PL-392.1 4155655 to 703 ORF_o386; alternate name ygiC; orfA of M77129

4156821 [Ξscherichia coli] gb| AAC76074.1 |

(AΞ000385) putative synthetase/amidase

[Escherichia coli K12] gb|AAG58177.l|AE005533_10 (AE005533) putative synthetase/amidase [Escherichia coli 0157 :H7] SEQ ID n~3084 pir| |D83072 conserved hypothetical protein

Contig9 from PA4584 [imported] - Pseudomonas

SΞQ ID n° 94S4 PL-331.1 4157046 to m 52% aeruginosa (strain PAOl)

4157876 gb|AAG07972.1 |AE004872_3 (AE004872) conserved hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~3075

pir| |C83072 conserved hypothetical protein

Contig9 from PA4583 [imported] - Pseudomonas SEQ ID n° 9495 PL-330.1 4157882 to m 81j aeruginosa (strain PAOl)

4159108 gb|AAG07971.l|AE004872_2 (AΞ004872) conserved hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~3068

pirj |_S71006 biotin carboxylase protein Al -

Contig9 from Saccharopolyspora erythraea emb | CAA63308.1 | SΞQ ID n° 9496 PL-389.1 4160365 to m 723 (X92556) biotin carboxylase and biotin carboxyl

4162143 carrier protein [Saccharopolyspora erythraea] SEQ ID n~S058

Contig9 from gb|AAC46262.l| (AF006000) unknown [Bordetella SEQ ID n° 9497 PL-388.1 4162152 to m 433 pertussis]

4163765 SEQ ID n~3049 Contig9 from emb ] CAB56671. l | (AL121596) hypothetical protein SΞQ ID n° 9498 PL-387.1 4163783 to m 623 SCF51A. 19 [Streptomyces coelicolor

4164559 A3 (2 ) ] SEQ ID n~3041 sp | P42673 | CP_PSBFL PYRROLIDONΞ-CARBOXYLATΞ

PEPTIDASE (5-OXOPROLYL-PEPTIDASE)

Contig9 from (PYROGLUTAMYL-PEPTIDASΞ I) (PGP-I) (PYRASE) SΞQ ID n° 9499 PL-386.1 4164646 to m 66% pir| |A55583 pyroglutamyl-peptidase I (ΞC

4165308 3.4.19.3) - Pseudomonas fluorescens emb|CAA53519.l| (X75319) TRANSFERRED ENTRY:

3.4.19.3 [Pseudomonas fluorescens] SEQ ID n~3031 pir| |A81 02 probable intégral membrane protein

Contig9 from CJ0553 [imported] - Campylobacter SΞQ ID n° 9500 PL-385.1 4165318 to m 60% jejuni (strain NCTC 11168) emb|CAB75183.l|

4166334 (AL133075) putative intégral membrane protein

[Campylobacter jejuni] SEQ ID n~S022

Contig9 from emb|CAB56670.l| (AL121536) possible intégral SEQ ID n° 9501 PL-384.1 4166334 to m 60% membrane protein [Streptomyces

4167062 coelicolor A3 (2)] SEQ ID n~3012 Contig9 from emb|CAB6168l.l| (AL133213) putative GntR-family SΞQ ID n° 9502 PL-383.1 4167524 to p 47% transcriptional regulator.

4168294 [Streptomyces coelicolor A3 (2)] SΞQ ID n~3004

Contig9 from gb|AAG5S474.l|AΞ00565S_3 (AΞ005653) Z5888 gène

SΞQ ID n° 9503 PL-5000.1 4168646 to 62% product—[Escherichia coli 0157 :H7]

4168882 #N/A

Contig9 from emb|CAB56727.l| (AL121600) hypothetical protein

SEQ ID n° 9504 PL-382.1 4169118 to m 51% SCF76.07 [Streptomyces coelicolor

4169759 A3 (2)] SEQ ID n~2996 pir| |T35271 probable ^"transcription regulator -

Contig9 from

Streptomyces coelicolor emb | CAB40696.1 |

SEQ ID n° 9505 PL-381.1 4169874 to 52% (AL049587) putative transcriptional regulator

4170863 [Streptomyces coelicolor A3 (2)] SEQ ID n~2987

^~Contig9 from

SEQ ID n» 9506 PL-5004.1 4170809 to m 523 emb|CAC05852.l| (AL391753) ORF173, CcdB,

4171033 #N/A

Contig9 from

SEQ ID n» 9507 PL-5005.1 4171034 to m 573 emb|CAC05851.l| (AL391753) ORF173a,

4171252 #N/A

ContigS from gb|AAF22961.l|AF157489_l (AF157489) Pin

SEQ ID n° 9508 PL-5006.1 4171413 to m 84% [Photorhabdus luminescens]

4171628 #N/A

Contig9 from gb|AAG59474.l|AE005659_9 (AΞ005659) Z5888 gène

SEQ ID n° S503 PL-5007.1 4171778 to 433 product [Ξscherichia coli 0157 :H7]

4172014 #N/A

Contig9 from

SEQ ID n° 3510 PL-380.1 4172148 to No Hits found

4172759 SEQ ID n~2977

Contig9 from

SEQ ID n° 9511 PL-373.1 4172929 to m No Hits found

4174125 SEQ ID n~2968

Contig9 from gb | AAD37770.1 | AF146532_10 (AF146532 )

SEQ ID n° 9512 PL-378.1 4174505 to 71% glycosyltransferase [Klebsiella pneumoniae]

4175494 SEQ ID n~2958

Contig9 from gb|AAK0385l.l| (AΞ006214) lunH [Pasteurella

SEQ ID n° 9513 PL-377.1 4175548 to 803 multocida]

4176438 SEQ ID n~2947

-SEÇT^"TD-n° ^" 9514^"" PL-376.1

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 9515 PL-375.1 4177752 to p 80% (strain PAOl) gb|AAG05705.1 ]AE004657_12

4179056 (AE004657) probable oxidoreductase [Pseudomonas aeruginosa] SEQ ID n~2929 pir| JF83357 hypothetical protein PA2318

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 9516 PL-3289.1 4179061 to p 423 (Strain PAOl) gb|AAG05706.1 | Ξ004657_13

4179489 (AΞ004657) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2537

Contig9 from - emb | CAA66106.1 [ (X97453J^~phenylacetaldehyde

SEQ ID n° 9517 PL-374.1 4179642 to p 653 dehydrogenase [Ξscherichia coli]

4181135 SEQ ID n~2923 pir|]G83574 hypothetical protein PA0574

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 9518 PL-373.1 4181217 to m 673 (strain PAOl) gb| AG03963.1 | E004493_8

4182314 (AΞ004493) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2913 pir| |F82602 conserved hypothetical protein

ContigS from XF2071 [imported] - Xylella fastidiosa SEQ ID n° 9519 PL-5009.1 4182545 to p 44? (strain 9a5c) gb| AAF84870.l| E004023_6

4182814 (AE004023) conserved hypothetical protein

[Xylella fastidiosa] #N/A pir| |A82602 conserved plasmid protein XF2066

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 9520 PL-5011.1 4182811 to p 453 (strain 9a5c) gb| AAF84865.l| AΞ004023_1

4183098 (AΞ004023) conserved plasmid protein [Xylella fastidiosa] #N/A

Contig9 from SΞQ ID n° 9521 PL-5012.1 4183280 to p No Hits found _ _4183711 _M/A pιr| |F83310 conserved hypothetical protein

Contig9 from PA2684 [imported] - Pseudomonas

SΞQ ID n° p 323 aeruginosa (strain PAOl)

gb | AAG06072 . 1 | AE004636_6 (AE004696 ) conserved hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2303

Contig9 from SEQ ID n° 9523 PL-5014.1 4188023 to p No Hits found

4188328 #N/A Contig9 from gb|AAG54899.l|AΞ005235_6 (AE005235) Z0702 gène SEQ ID n° 9524 PL-3291.1 4188424 to 23? product [Escherichia coli 0157 :H7]

4188948 SΞQ ID n~2539 Contig9 from SEQ ID n° 9525 PL-371.1 4188964 to No Hits found — 4189575 SEQ ID n~2895

Contig9 from gb|AAC26596.l| (U83995) putative protease SEQ ID n° 9526 PL-370.1 4189678 to 53% [Porphyromonas gingivalis]

4190562 SEQ ID n~2887 Contig9 from SEQ ID n° 9527 PL-7100.1 4190602 to p No Hits found

sp|P5 794|MOAR_KLEAE MONOAMINE REGULON

Contig9 from TRANSCRIPTIONAL REGULATOR pir| | A36937 monoamme SΞQ ID n° 9528 PL-369.1 4191012 to m 61% regulon positive regulator MoaR - Klebsiella

4191671 pneumoniae dbj |BAA03667.1 | (D15072) regulator protein [Klebsiella aerogenes] SEQ ID n~2876 pιr| |G83136 probable amino acid permease PA4072

ContigS from [imported] - Pseudomonas aeruginosa SΞQ ID n° 9529 PL-368.1 4192245 to 79% (strain PAOl) gb|AAG07459.l|AE004823_5

41S3738 (AEO 04823) probable amino acid permease

[Pseudomonas aeruginosa] SEQ ID n~2866

pir| |F83136 hypothetical protein PA4071

Conti 9 from [imported] — Pseudomonas aeruginosa SΞQ ID n° 9530 PL-367.1 4193809 to 343 . ( strain PAOl) qb|AAG07458. l_j_AE_004823_4

4194309 (AΞ004823) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2856

Contig9 from SEQ ID n° 9531 PL-5017.1 419439T Ô^" No Hits found

4194792 #N/A Contig9 from SΞQ ID n° 9532 PL-366.1 41S4785 to No Hits found

4Ï35747 SΞQ ID n~2846 ContigS from emb|CAB71551.l| (AJ270937) aromatic amino acid SΞQ ID n° 3533 PL-365.1 4196090 to 32% decarboxylase [Sorangium cellulosum]

4197538 SEQ ID n~2838 Contig9 from gb]AAG27518.l]AF230494_l (AF230494) L-ornithine SΞQ ID n° 9534 PL-364.1 4197563 to m N5 -hydroxylase [Pseudomonas sp. Bio]

4198864 SEQ ID n~28-29 sp|P21175|BRAC_PSEAE LEUCINΞ-, ISOLΞUCINΞ-, VALINE-, THREONINE-, AND ALANINE-BINDING PROTEIN PRΞCURSOR (LIVAT-BP) (LEU/ILE/VAL/THR/ALA-BINDING PROTEIN) pir| |A36125 ABC-type transport system branched- chain amino acid-binding protein braC

Contig9 from precursor [validated] - Pseudomonas aeruginosa SΞQ ID n° 9535 PL-363.1 4198867 to 333 (strain PAO) pir| |H83509 branched-chain amino

4199832 acid transport protein BraC PA1074 [imported] - Pseudomonas aeruginosa (strain PAOl) dbj |BAA14254.l| (D90223) BraC (periplasmic protein) [Pseudomonas aeruginosa] gb|AAG04463.l|AΞ004539_5 (AE004533) branched- chain amino acid transport protein BraC [Pseudomonas aeruginosa] SΞQ ID n~2824

pir| JG75122 sarcosine oxidase, chain beta (soxb) ContigS from PAB1843 - Pyrococcus abyssi - (strain

SΞQ ID n° 9536 PL-362.1 4199843 _tθ _„__ m 38% Ors.ay) emb|CAB49696. l| (AJ248285) sarcosine

4200970 oxidase, subunit beta (soxB) [Pyrococcus abyssi] SEQ ID n~2816

pir| |T35923 probable tRNA synthetase -

Contig9 from

Streptomyces coelicolor emb|CAA22745.l|

SEQ ID n° 9537 PL-361.1 4200973 to m 403

(AL035206) putative tRNA synthetase

4202466

[Streptomyces coelicolor A3 (2) ] SEQ ID n~2806 pir[ |T35922 hypothetical protein SC9B5.02 - Contig9 from

Streptomyces coelicolor emb| CAA22744.l|

SΞQ ID n° 9538 PL-5019.1 4202469 to 383

(AL035206) hypothetical protein SC9B5.02

4202837

[Streptomyces coelicolor A3 (2)] #N/A

Contig9 from dbj |BAB06343.l| (AP001516) diaminobutyrate- - SΞQ ID n° 3533 PL-360.1 4202834 to 56% pyruvate transaminase [Bacillus

4204201 halodurans] SΞQ ID n~2798 sp | Q51548 | PVDA_PSEAΞ L-ORNITHINΞ-5 -MONOOXYGENASE

(L-ORNITHINE N5-OXYGENASΞ) pir | |D83346 L-

Contig9 from ornithine N5-oxygenase PA2386 [imported] - -SEQ ID n° 9540 PL-359.1 4204203 to m 52%

Pseudomonas aeruginosa (strain PAOl)

4205528 gb|AAG05774.l|AΞ004665_l (AE004665) L-ornithine

N5-oxygenase [Pseudomonas aeruginosa] SΞQ ID n~2789 pirj |Ξ83496 hypothetical protein PA1186

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 9541 PL-358.1 4205581 to m 663 (Strain PAOl) gb| AAG04575.l| AΞ004549_2

4206540 (AΞ004549) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2780 pir| |E83498 probable transcription regulator

PA1184 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 9542 PL-357.1 4206941 to 63% gb|AAG04573.l|AE004548_7 (AΞ004548) probable

4207879 transcriptional regulator [Pseudomonas aeruginosa] SΞQ ID n~2771

pir| |D83496 probable glutathione S-transferase

SΞQ ID n° 9543 ^~P

SΞQ ID n° 9544 PL-355.1 4209216 to 52? hydroxylase component A [Bacillus

4210661 ther oglucosidasius] SEQ ID n~2750 pir| |B83340 hypothetical protein PA2451

Contig9 from [imported] - Pseudomonas aeruginosa ΞΞQ ID n° 9545 PL-354.1 4210956 to 223 (strain PAOl) gb] AAG0583S .l| E004672_7

4212584 (AΞ004572) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2741

ContigS from gb|AAG54729.l|AE005217_7 (AE005217) alkaline SEQ ID n° 9546 PL-353.1 4212689 to 783 phosphatase [Escherichia coli 0157 :H7]

4214131 SEQ-ID n~2734 pir] |D71676 bicyclomycin résistance protein

Contig9 from (bcr2) RP698 - Rickettsia prowazekii SΞQ ID n° 9547 PL-352.1 4214475 to 463 emb|CAA15134.l| (AJ235272) BICYCLOMYCIN

4215695 RESISTANCΞ PROTEIN (bcr2) [Rickettsia prowazekii] SEQ ID n~2729

ContigS from SEQ ID n° 9548 PL-5022.1 4215740 to No Hits found

4215937 #N/A Contig9 from SΞQ ID n° 9549 PL-3293.1 4216051 to m No Hits found

4216266 SEQ ID n~2540 ContigS from SΞQ ID n° 9550 PL-5023.1 4216214 to No Hits found

4216426 #N/A Contig9 from SΞQ ID n° 9551 PL-5024.1 4216613 to No Hits found

4216738 #N/A

sp|P39406|RSMC_ΞCOLI RIBOSOMAL RNA SMALL SUBUNIT

MΞTHYLTRANSFΞRASΞ C (RRNA _ _ _ (GUANINE-N2

) -METHYLTRANSFERASE) (16S RRNA M2G1207

Contig9 from METHYLTRANSFΞRASΞ) pir| |S56595 hypothetical

SEQ ID n° 9552 PL-351.1 4216896 to m 66% 37.6K protein (dnaT-holD intergenic région) -

4217912 Ξscherichia coli gb]AAA97267.l| (U14003) ORF_f343b^" [Escheric5hïâ^" côli] gb |^"AAC77324. l | (AΞ000507) putative enzyme [Escherichia coli

K12] SΞQ ID n~2722 sp|P28632 |H0LD_EC0LI DNA POLYMERASE III, PSI

SUBUNIT pir| |A48647^" DNA-directed DNA polymerase

(EC 2.7.7.7) III psi chain -

Escherichia coli gb|AAA03076. l| (L05387) DNA

Contig9 from polymerase III psi subunit [Escherichia coli] SΞQ ID n° 9553 PL-3294.1 4218043 to 48? gb|AAA24435.l| (L04575) DNA polymerase III psi

4218456 subunit [Ξscherichia coli] gb| AAA97268.1]

(U14003) DNA polymerase III psi subunit

[Ξscherichia coli] gb |AAC77325. l| (AE000507)

DNA polymerase III, psi subunit [Escherichia coli K12] SΞQ ID n~2541 sp | 09453 | RIMI_ΞCOLI RIBOSOMAL-PROTEIN-ALANINE

ACΞTYLTRANSFFRASΞ (ACΞTYLATING ENZYME FOR

N-TERMINAL OF RIBOSOMAL PROTEIN S18) pir| |D65252 ribosomal-protein-alanine N- acetyltransferase (EC 2.3.1.128) riml -

Escherichia coli (strain K-12) gb| AAC77326.l|

ContigS from

(AE000507) acyltransferase for 30S ribosomal

SΞQ ID n° 9554 PL-3295.1 4218425 to 693 subunit protein S18 ,- acetylation of N

4218871 terminal alanine [Escherichia coli K12] gb|AAG59553.l]AE005668_8 (AΞ005668) acyltransferase for 3 OS ribosomal subunit protein S18; acetylation of N- terminal alanine [Escherichia coli

0157 :H7] SΞQ ID n~2542

Contig9 from sp|Q5612l|RF3_SALTY PEPTIDE CHAIN RΞLΞASE FACTOR

SEQ ID n° 9555 PL-350.1 4219028 to 92% ,_3 (RF-3) dbj |BAA09090.l| (D50496) peptide

4220617 release factor 3/RF3 [Salmonella typhimurium] SEQ ID n~2715

Contig9 from gb|AAG59556.l|AE005668_ll (AE005668)

SΞQ ID n° 9556 PL-5025.1 4221004 to 62? hyperosmotically inducible periplasmic protein

4221381 [Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG59558.l|AE005669_2 (AΞ005669) orf,

SEQ ID n° 9557 PL-343.1 4221577 to 693 hypothetical protein [Escherichia coli 0157 :H7]

4222584 SΞQ ID n~2705

Contig9 from emb|CAB41498.l| (AJ238399) hypothet_ica,l_

SEQ iτrn^c~355^"8 PL-5026.1 4222600 to 77% transposase [Bscherichia coli]

4222746 #N/A

Contig9 from

SΞQ ID n° 9559 PL-5028.1 4222791 to m No Hits found

4222922 #N/A

Contig9 from

SEQ ID n°__5560 PL-348.1 4222962 to No Hits_ found

4223618 SΞQ ID n~2696

Contig9 from gb|AAF97408.l| (AY004320) photopexin B

SEQ ID n° 9561 PL-347.1 4224065 to m 95% [Photorhabdus luminescens]

4225087 SEQ ID n~2687

Contig9 from gb|AAF97407.l| (AY004319) photopexin A

SEQ ID n° 9562 PL-346.1 4225181 to m 963 [Photorhabdus luminescens]

4226875 SΞQ ID n~2676

Contig9 from

SΞQ ID n° 9563 PL-345.1 4227200 to p No Hits found

4228081 SΞQ ID n~2665

Contig9 from

SEQ ID n° 9564 PL-3296.1 4228582 to m No Hits found

4229001 SEQ ID n~2543

Contig9 from

SΞQ ID n° 9565 PL-344.1 4229589 to No Hits found

4230377 SEQ ID n~2656

Contig9 from gb|AAF97407.l| (AY004319) photopexin A

SΞQ ID n° 3566 PL-343.1 4230696 to m 31% [Photorhabdus luminescens]

4231658 SΞQ ID n~2648

Contig9 from gb|AAF81206.l]AF247502_l (AF247502) Ytl2

SEQ ID n° 9567 PL-342.1 4232400 to 663 [Salmonella dublin]

4233410 SEQ ID n~2642 ref ]NP_047874.l] putative transposase [Yersinia pestis] pir] |T14989 probable transposase -

Contig9 from

Yersinia pestis plasmid pMTl gb|AAC8273 .l| SEQ ID n° 3568 PL-5032. l__ 23_3S4-0—tθ— -p.-- 723

(AF07461D putative transposase [Yersinia

4233764 pestis] emb|CAB55253.l| (AL117211) hypothetical protein YPMT1.71 [Yersinia pestis] #N/A ref |NP_047874.l| putative transposase [Yersinia pestis^"] pï^~rp[^"Tl4989 probable transposase -

ContigS from

Yersinia pestis plasmid pMTl gb| AAC8273 .l| SEQ ID n° 3569 PL-5033.1 4233834 to 723

(AF074611) putative transposase [Yersinia

4234118 pestis] emb|CAB55253.l| (AL117211) hypothetical protein YPMT1.71 [Yersinia pestis] #N/A ref |NP_073225.l| ransposase of IS630 [Salmonella enterica .serovar Choleraesuis] dbj |BAA01531. l|

ContigS from

(D10689) M5 protein [Salmonella choleraesuis] SΞQ ID n° S570 PL-5034.1 4234348 to 70% dbj |BAB20556.l] (AB040415) ransposase of IS630

4234584

[Salmonella enterica serovar

Choleraesuis] #N/A

Contig9 from pir]|S76748 hypothetical protein - Synechocystis

SEQ ID n° 9571 PL-3297.1 4234796 to 543 sp. (strain PCC 6803) dbj |BAA18660. l| (D90916)

4235356 hypothetical protein [Synechocystis sp.] SEQ ID n~2544 pir| |G70852 hypothetical protein Rv3083 -

Contig9 from

Mycobacterium tuberculosis (strain

SEQ ID n° 9572 PL-341.1 4235418 to m 683

H37RV) emb|CAA16141.l| (AL021309) hypothetical

4236866 protein Rv3083 [Mycobacterium tuberculosis] SEQ ID n~2637

Contig9 from gb|AAF97407.l| (AY004319) photopexin A

SEQ ID n° 9573 PL-340.1 4237406 to m 743 [Photorhabdus luminescens]

4238407 SEQ ID n~2631

Contig9 from gb|AAF97407.l| (AY004319) photopexin A

SEQ ID n° 9574 PL-339.1 4238827 to m 293 [Photorhabdus luminescens]

4239765 SEQ ID n-2624

ContigS from gb|AAF63418.l| (AF146029) putative multidrug- SEQ ID-n°- 3575 PL-338.1 4240182 to 433 resistance protein [Aeromonas — 4241393 hydrophila] SΞQ ID n~2614_

Co SEQ ID n° 3576 PL-5035.1 4

ContigS from VCA0108 [imported] - Vibrio cholerae SEQ ID n° 3577 PL-337.1 4243020 to 573 (group 01 strain N16961) gb | AAF96022.1 |

4244552 (AΞO 04353) conserved hypothetical protein

[vibrio cholerae] SΞQ ID n~2603 pir| |D83634 hypothetical protein PAO079

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 9578 PL-336.1 4244569 to 41% (strain PAOl) gb |AAG03469.1 | AE004447_2

4245930 (AE004447) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2596 pir| |F82499 hypothetical-protein VCA0115

Contig9 from

[imported] - Vibrio cholerae (group SEQ ID n° 9579 PL-335.1 4245973 to p 363

01 strain N16961) gb| AAF96029.1 | (AE004353)

4246617 hypothetical protein [Vibrio cholerae] SΞQ ID n~2586 pir| ]B82819 outer membrane protein XF0343

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 9580 PL-334.1 4246634 to 11% (strain 9a5c) gb|AAF83153.l|AE003886_12

4248310 (AΞ003886) outer membrane protein [Xylella fastidiosa] SEQ ID n-2578 pir| |E83349 probable ClpA/B-type proteinase

Contig9 from PA2371 [imported] - Pseudomonas SEQ ID n° 9581 PL-333.1 4248559 to 60% aeruginosa (strain PAOl)

4251240 gb|AAG05759.l|AE004663_5 (AE004663) probable

ClpA/B-type protease [Pseudomonas aeruginosa] SEQ ID n~2569 pir| ]C83458 conserved hypothetical protein

Contig9 from PA1511 [imported] - Pseudomonas SΞQ ID n° 9582 PL-332.1 4251237 to 41% aeruginosa (strain PAOl)

4253615 gb|AAG04900.l|AΞ004579_12 (AΞ004579) conserved hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~255S

Contig9 from SΞQ ID n° 9583 PL-331.1 _4253626 to No Hits found

4254666 SEQ ID n~2554

Contig9 from SEQ ID n° 9584

SEQ ID n° 9585 PL-329.1 4257263 to No Hits found

4258273 SEQ ID n~2538 Contig9 from SEQ ID n° 9586^"—PL=328.1 4258351 to No Hits found

425S340 SEQ ID n~2527 Contig9 from SEQ ID n° 3587 PL-327.1 4259526 to p No Hits found

4260134 SEQ ID n~251S pir| |H83457 hypothetical protein PA1508

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 9588 PL-5042.1 4260222 to p 383 (Strain PAOl) gb|AAG04897.l|AE004579_9

4260497 (AE004579) hypothetical protein [Pseudomonas aeruginosa] #N/A

Contig9 from SEQ ID n° 9589 PL-326.1 4260500 to No Hits found

4261675 SEQ ID n~2503 pir| |G83637 hypothetical protein PA0077

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 9590 PL-325.1 4261668 to 26% (Strain PAOl) gb|AAG03467.l|AE004446_15

4265027 (AEO 04446) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2500

Contig9 from SΞQ ID n° 9591 PL-5044.1 4265440 to No Hits found

4265628 #N/A Contig9 from SΞQ ID n° 9592 PL-5045.1 4265629 to No Hits found

4265799 #N/A

pir] |B83613 secreted protein Hep PA0263

[imported] - Pseudomonas -aeruginosa

(strain PAOl) pir|]C83455 secreted protein Hep

PA1512 [imported] - Pseudomonas aeruginosa

(strain PAOl) pir| |G82987 secreted protein Hep

Contig9 from

PA5267 [imported] - Pseudomonas aeruginosa

-SΞQ ID n° 9593 PL-3301.1 265 72— o≈z -rp- - 8%

(strain PAOlI^-gE^"!AAG03652.11AE004464_5 4266263

(AEO04 64) secreted protein Hep [Pseudomonas aeruginosa] gb| AAG04901.1 | AΞ004580_1 (AΞ004580) secreted protein Hep [Pseudomonas aeruginosa] gb|AAG08652.l|AΞ00493^"9_4 (AΞ004939) secreted protein Hep [Pseudomonas aeruginosa] SΞQ ID n~2547

Contig9 from

SΞQ ID n° 9594 PL-322.1 4266364 to No Hits found

4268970 SEQ ID n~2473

Contig9 from

SΞQ ID n° 9595 PL-321.1 4268967 to No Hits found

4269575 SΞQ ID n~2462

Contig9 from pdb|lF3l|A Chain A, Crystal Structure Of Tn5

SΞQ ID n° 9596 PL-320.1 4269576 to 573 Transposase Complexed With Transposon

4270958 End Dna SΞQ ID n~2451

Contig9 from

SΞQ ID n° 9597 PL-5049.1 4271128 to No Hits found

4271451 #N/A

Contig9 from

SΞQ ID n° 9598 PL-319.1 4271528 to p No Hits found

4272529 SEQ ID n~2439

Contig9 from

SEQ ID n° 9599 PL-318.1 4272740 to p No Hits found

4273483 SEQ ID n~2428

Contig9 from

SΞQ ID n° 9600 PL-5050.1 4273521 to p No Hits found

4273646 #N/A

pir] |B83439 hypothetical protein PA1656 Contig9 from

SΞQ ID n° 9601 PL-317.1 4273649 t p

4275247

aeruginosa] SΞQ ID n~2417

pir| |A82499 hypothetical protein VCAOIIO

— Contig9 from

[imported] - Vibrio cholerae (group

SΞQ ID n° 9602 PL-315.1 4275326 to 48%

01 strain N16961) gb | AAF96024.1 | (AE004353)

4277092 hypothetical protein [Vibrio cholerae] SΞQ ID n~ 395

Contig9 from gb|AAG54528.1 AE005198_9 (AE005198_._Z0 .59 gène SΞQ ID h°^~~9603 PL-314 . 1 4277092 to 403 product [Ξscherichia coli 0157 :H7]

4278132 SΞQ ID n~2384 pir| |E83437 hypothetical protein PA1666

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 9604 PL-3302.1 4278113 to p 27% (strain PAOl) gb ( AAG05055.1 | AE004594_7

4278649 (AΞ004594) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2548 pir| |Ξ83439 hypothetical protein PA1659

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 9605 PL-5051.1 4278653 to p 31% (strain PAOl) gb| AAG05048.1 | Ξ004593_10

4279087 (AΞ004593) hypothetical protein [Pseudomonas aeruginosa] /A

Contig9 from gb|AAG54518.l|AΞ005197_7 (AE005197) Z0249 gène SEQ ID n° 9606 PL-313.1 4279139 to p 48% product [Escherichia coli 0157 :H7]

4280518 SEQ ID n~2373 sp|P33562|T2BB_BACSU TYPE II RESTRICTION ENZYME

BSUBI (ENDONUCLΞASΞ BSUBI) (R.BSUBI)

Contig9 from pir||S35516 type II site-specific SEQ ID n° 9607 PL-3304.1 4280704 to p 223 deoxyribonuclease (BC 3.1.21.4) BsuBI -

4281198

Bacillus subtilis gb|AAA18170.1] (L01541) restriction endonuclease [Bacillus subtilis] SEQ ID n~2549

Contig9 from gb|AAG57124.l|AE005432_5 (AE005432) Z3230 gène SEQ ID n° 9608 PL-5052.1 4281718 to p 29% product [Escherichia coli 0157 :H7]

4282131 #N/A

Contig9 from gb |AAG57125.1 | AE005432_6 (AΞ005432) Z3231 gène SEQ ID n° 9603 PL-5053.1 4282222 to 383 product [Ξscherichia coli 0157 :H7]

4282539 -#H/_- pir| |S35196 hypothetical protein 3 -

Contig9 from

Saccharopolyspora hirsuta gb|AAA26487.1 |

SEQ ID n° 9610 PL-312.2 4283514 to 623

(M98258) polyketide reductase [Saccharopolyspora -42-8-4-290—— hirsuta] SEQ ID n~2362

Contig9 from SΞQ ID n° 9611 PL-311.1 4284293 to 333 gb|AAD10395.l] (U46488) NrpG [Proteus mirabilis]

4285006 SΞQ ID n~2351 Contig9 from gb|AAF01818.l|AF187532_14 (AF187532) putative SEQ ID n° 9612 PL-310.1 4284S99 to 573 polyketide cyclase [Streptomyces nogalater]

4285814 SΞQ ID n-2340 sp|Q02578|KASl_STRCN PUTATIVΞ POLYKETIDΞ BΞTA-

KΞTOACYL SYNTHASΞ 1 pir||jC1210 polyketide beta ketoacyl synthase (EC 2.3.1.-) chain 1 -

Contig9 from

Streptomyces cyaneus gb|AAA26726.l| (M33704) SEQ ID n° 9613 PL-309.1 4286466 to 59% curA protein [Streptomyces curacoi]

4287752 emb]CAA44380.l| (X62518) beta-ketoacyl synthase

[Streptomyces cyaneus] prf | ] 1807129B curA gène

[Streptomyces cyaneus] SΞQ ID n~2328 pir| |H82776 3 -oxoacyl- [ACP] synthase II XF0673

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 9614 PL-308.1 4287745 to 34% (strain 9a5c) gb| AAF83483. l| AE003911_5

4288860 (AΞ003911) 3 -oxoacyl- [ACP] synthase II [Xylella fastidiosa] SEQ ID n~2317

Contig9 from SEQ ID n° 9615 PL-5054.1 4288895 to No Hits found

4289143 #N/A Contig9 from dbj ]BAB05725.l| (AP001514) long-chain acyl-CoA SEQ ID n° 9616 PL-307.1 4289167 to 44% synthetase (ligase) [Bacillus

4290714 halodurans] SBQ ID n~2306 Contig9 from gb|AAF00205.l|AF164S60_l (AF164S60) cyclase SΞQ ID n° 9617 PL-306.1 4290714 to 27% [Streptomyces fradiae]

4292156 SEQ ID n~22 S5

Contig9 from pir] [T30216 hypothetical protein Z -

SEQJDm⁰ 9618 PL- 305 . 1 4292176 to p -23%^- Streptomyces hygroscopicus emb|CAA60450.l|

4293330 (X86780) orfz [Streptomyces hygroscopicus] SΞQ ID n~2284 pir| ]Ξ75566 probable repressor protein -

Contig9 from

Deinococcus radiodurans (strain RI)

SEQ ID n° 9619 PL-304.1 4294283 to 27% gb|AAF09645.l|AE001868_7 (AB001868) repressor 4294984 - protein, putative [Deinococcus radiodurans] SEQ ID n~2273

Contig9 from SEQ ID n° 9620 PL-5055.1 4295628 to m No Hits found

4295972 #N/A sp|P53554|BIOI_BACSU BIOTIN BIOSYNTHESIS;

CYTOCHROMB P450-LIKΞ ΞNZYME pir[|G69594 cytochrome P450 biol - Bacillus subtilis

Contig9 from gb|AABl7462.l| (U51868) cytochrome P450-like SEQ ID n° 9621 PL-303.1 4297001 to 20% enzyme [Bacillus subtilis] gb|AAC00266.l|

4298104

(AF008220) cytochrome P450 enzyme [Bacillus subtilis] emb|CAB14997.1-|- (Z99119) cytochrome

P450-like enzyme [Bacillus subtilis] SEQ ID n~2262

ContigS from gb|AAC38630.1] (AF047028) insecticidal toxin

SEQ ID n° 9622 PL-302.1 4298421 to m 53% complex protein TccC [Photorhabdus

4301318 luminescens] SΞQ ID n~2251

Contig9 from pir] |S28478 rfbN protein - Vibrio cholerae

SEQ ID n° 9623 PL-301.1 4303031 to 383 emb|CAA42144.l| (XΞ9554) rfbN [Vibrio cholerae]

4304161 prf | [2203284D rfbN gène [Vibrio cholerae] SΞQ ID n~2241 pir] |A42951 fatty-acyl-CoA reductase (EC 1.2.1.-

Contig9 from

) luxC - Xenorhabdus luminescens

SEQ ID n° 9624 PL-300.1 4304163 to 17% gb]AAD05355.l| (M90092) fatty acid reductase

4306568

[Xenorhabdus luminescens] SΞQ ID n~2230

Contig9 from dbj |BAA75335.l| (AB011837) ORF12 [Bacillus

SEQ ID n° 9625 PL-299.1 4306538 to 43% halodurans]

4307869 SΞQ ID n~2217

ContigS from gb|AAC44553.l| (U34346) unknown [Paracoccus

SEQ ID n° 9626 PL-2S8.1 4307866 to 19% denitrificans]

4308789 SΞQ ID n~2206

Contig9 from pir| |A56394 pyocin S3 - Pseudomonas aeruginosa SΞQ ID n° 9627 PL-296.1__ 4309190 to 27% (strain P12) emb| CAA54958.1 | (X77996) killer

4310851 protein of pyocin S3 [Pseudomonas aeruginosa] SEQ ID n~2184 pir| |B563S4 pyocin S3 immunity protein -

Contig9 from

Pseudomonas aeruginosa (strain P12)

SΞQ ID n° 9628 PL-3306.1 4310848 to 433 emb| CAA54959.1 | (X77996) immunity protein of 4311306 pyocιn^"~S3 [Pseudomonas aeruginosa] — ^"SΕQ ID n~^"2550 pir| |B56394 pyocin S3 immunity protein -

Contig9 from

Pseudomonas aeruginosa (strain P12) SΞQ ID n° 9629 PL-3307.1 4311415 to p 35% emb|CAA54959.l| (X77996) immunity protein of 4311882

^~ pyocin S3 [Pseudomonas aerugmosa] -SEQ ID n~2551 pir| |B56394 pyocin S3 immunity protein -

Contig9 from

Pseudomonas aeruginosa (strain P12) SΞQ ID n° 9630 PL-3308.1 4311991 to p 32% emb| CAA54S53.l| (X77336) immunity protein of

4312458 pyocin S3 [Pseudomonas aeruginosa] SEQ ID n~2552 pir| |B563Θ4 pyocin S3 immunity protein -

Contig9 from

Pseudomonas aeruginosa (strain P12) SΞQ ID n° 9631 PL-3309.1 4312566 to p 45% emb|CAA54959.l| (X77996) immunity protein of

4313027 pyocin S3 [Pseudomonas aeruginosa] SEQ ID n~2553 pir] |B56394 pyocin S3 immunity protein -

Contig9 from

Pseudomonas aeruginosa (strain P12) SEQ ID n° 9632 PL-3310.1 4313137 to p 54% emb|CAA54959.l| (X77336) immunity protein of

4313604 pyocin S3 [Pseudomonas aeruginosa] SΞQ ID n~2555 pir| |B56334 pyocin S3 immunity protein -

Contig9 from

Pseudomonas aeruginosa (strain P12)

SEQ ID n° 9633 PL-3311.1 4313696 to p 31% emb| CAA5435S.l| (X773S6) immunity protein of

4314163 pyocin S3 [Pseudomonas aeruginosa] SEQ ID n~2556 pir| |B56334 pyocin S3 immunity protein -

Contig9 from

Pseudomonas aeruginosa (strain P12) SΞQ ID n° S634 PL-3312.1 4314272 to 34% emb| CAA54959.l| (X77996) immunity protein of

4314739 pyocin S3 [Pseudomonas aeruginosa] SEQ ID n~2557

Contig9 from gb|AAC38628.l| (AF047028) insecticidal toxin SΞQ ID n° 9635 PL-295.1 4315167 to 93% complex protein TccA [Photorhabdus

4318067 luminescens] SΞQ ID n-2173

Contig9 from gb|AAC38629.l| (AF047028) insecticidal toxin

SΞQ ID n° 9636 PL-294.1 4318162 to 963 complex protein TccB [Photorhabdus

4322856 luminescens] SΞQ ID n~2_162

Contig9 from gb|AAC38630.l| (AF047028) insecticidal toxin

SΞQ ID n° 9637 PL-293.1 4322990 to 96% complex protein TccC [Photorhabdus

4326121 luminescens] SΞQ ID n~2152

Coriti 3^~"ffom gb] AAC38631.11 (AF0470^~28) insecticidal toxin

SEQ ID n° 9638 PL-5065.1 4326202 to m 693 complex protein TccZ [Photorhabdus

4326357 luminescens] #N/A Contig9 from

SEQ ID n° 9639 PL-5066.1 4^~3^"26445 to No Hits found

4326747 #N/A gb|AAG55308.l|AΞ005273_l (AE005273) unknown in

Contig9 from

ISΞc8 [Ξscherichia coli 0157 :H7]

SEQ ID n° 9640 PL-5067.1 4326741 to 733 gb|AAG557l7.l|AEθ0530S_7 (AE005309) unknown in

4327076

ISEcδ [Ξscherichia coli 0157 :H7] #N/A

Contig9 from ref |NP_053113- l| orf51 [Escherichia coli]

SEQ ID n° 3641 PL-292.1 4327140 to 533 dbj ]BAA84886.l| (AB024946) or 51 [Escherichia

4328645 coli] SEQ ID n~2141 Contig9 from gb|AAC38631.l| (AF047028) insecticidal toxin

SEQ ID n° 9642 PL-5069.1 4328684 to 79% complex protein TccZ [Photorhabdus

4328950 luminescens] #N/A sp|P37535| AAN_BACSU HYPOTHETICAL 43.8 KD

PROTEIN IN XPAC-ABRB INTERGENIC REGION

Contig9 from pιr||S66056 yaaN protein - Bacillus subtilis SEQ ID n° 9643 PL-291.2 4329677 to 58% dbj |BAA05262.l| (D26185) unknown [Bacillus

4330780 subtilis] emb|CAB11802.l| (Z99104) similar to toxic cation résistance [Bacillus subtilis] #N/A

Contig9 from SEQ ID n° 9644 PL-290.1 4330841 to No Hits found

4331890 SΞQ ID n~2119 pιr||F75337 transposase - Deinococcus

Contig9 from radiodurans (strain RI) SEQ ID n° 9645 PL-3319.1 4332262 to m 623 gb|AAF11477.l|AE002031_6 (AE002031) transposase

4332690

[Deinococcus radiodurans] SΞQ ID n~2558

Contig9 from gb|AAG12476.l|AC037197_l (AC037197) Putatitve SΞQ ID n° 9646 PL-289.1 4333081 to 363 histidine decarboxylase [Oryza sativa] 4334163 .SBQ ID n~2107 pir||F75337 transposase - Deinococcus

Contig9 from radiodurans (strain RI)

SEQ ID n° 9647 PL-3320.1 4334232 to 623

_gb_|AAF11477.l]AΞ0_02031_6_ (AΞ002031) transposase

^~ — - - 4334660

[Deinococcus radiodurans] SΞQ ID n~2560

Contig9 from emb|CAA70530.l| (Y09356) pyridoxal-dependent SΞQ ID n° 9648 PL-3321.1 4334762 to 39% histidine decarboxylase [Pseudomonas

4335220 fluorescens] SEQ ID n~2561 pir| |T36373 hypothetical protein SCE94.13 -

Contig9 from

Streptomyces coelicolor emb|CAB40862. l| SEQ ID n° 9649 PL-288.1 4335562 to m 603

(AL049628) hypothetical protein [Streptomyces

4336176 coelicolor A3 (2)] SEQ ID n~2096 pir| |T36372 probable asnC-family transcription regulator - Streptomyces coelicolor Contig9 from emb|CAA10328.l| (AJ131213) putative

SΞQ ID n° 9650 PL-3322.1 4336438 to 71% transcriptional regulator [Streptomyces

4336902 coelicolor A3 (2)] emb|CAB40861.l| (AL049628) putative AsnC-family transcriptional regulator

[Streptomyces coelicolor A3 (2)] SEQ ID n-2562

Contig9 from SΞQ ID n° 3651 PL-5072.1 4337118 to m No Hits found

4337408 #N/A ContigS from SEQ ID n° 3652 PL-287.1 4337326 to No Hits found

43335S3 SEQ ID n~2085 ContigS from dbj |BAB06239.l| (AP001515) transposase related SΞQ ID n° 3653 PL-286.1 4340154 to 21% protein (20) [Bacillus halodurans]

434117S SEQ ID n~2074 ContigS from dbj |BAB18040.l| (AB033991) BtrA [Bacillus SΞQ ID n° 3654 PL-285.1 4341677 to 453 circulans]

4345360 SEQ ID n~2064 ContigS from SΞQ ID n° 9655 PL-5077.1 4345379 to No Hits found

4345732 #N/A

Contig9 from

SEQ ID n° 9656 PL-5079.1 .4345737 to No Hits found 4345853 -J_CLN/A-

Contig9 from

SEQ ID n° 9657

SEQ ID n° 9658

SEQ ID n° 9659

pir| JD82414 agmatinase VCA0814 [imported] -

Contig9 from Vibrio cholerae (group 01 strain

SEQ ID n° 3660 PL-282.1 4348897 to 253 N16961) gb|AAFS6712.l| (AΞ004409) agmatinase

4350156 - — [Vibrio cholerae] SEQ -ID n~2032

Contig9 from emb CAC19891.1 (AJ011301) toxin B [Clostridium

SEQ ID n» 9661 PL-281.1 4350900 to P 7% difficile]

4360028 SEQ ID n~2021

Contig9 from

SEQ ID n° 9662 PL-5089.1 4360068 to p No Hits found

4360391 #N/A pir] |S56363 divalent cation tolérance protein cutA3, inner membrane - Escherichia coli gb|AAA37034.l| (U14003) yjdC [Escherichia

Contig9 from coli] emb|CAA85376.l| (Z36305) 133 residue SEQ ID n° 9663 PL-278.1 4360973 to m 723 polypeptide [Escherichia coli] gb] AAC77095.1 |

4361566 (AΞ000486) orf, hypothetical protein

[Ξscherichia coli K12] gb| AG59334.l| AE005647_3

(AΞO056 7) orf, hypothetical protein

[Ξscherichia coli 0157 :H7] SEQ ID n~2987

Co

-SΕ@-ïD-n°-9664 PL-277.1 4

TRANSPORTER DCUA pir||S56366 dicarboxylate membrane-transporter protein A - Ξscherichia coli pir||QQΞC94 dicarboxylate membrane- transporter protein A - Escherichia coli emb|CAA56259.l| (X79887) dicarboxylate membrane- transporter protein [Escherichia

Contig9 from coli] gb|AAA97037.1| (U14003) genA [Escherichia

SEQ ID n° 9665 PL-276.1 4363475 to 903 coli] gb| AB30213.1] GenA=integral inner-

4364776 membrane protein involved in anaerobic

C4-dicarboxylic acid- transport [Escherichia coli, K12, Peptide, 433 aa] gb|AAC77098.l| (AE000486) anaerobic dicarboxylate transport [Escherichia coli K12] gb|AAG59337.l|AΞ005647_6 (AΞ005647) anaerobic dicarboxylate transport [Ξscherichia coli

0157 :H7] SEQ ID n-3.965 sp|P33109|ASPA_SERMA ASPARTATE AMMONIA-LYASE

Contig9 from (ASPARTASΞ) pir| | JS0764 aspartate ammonia-lyase

SEQ ID n° 9666 PL-275.1 4364917 to m 913 (ΞC 4.3.1.1) - Serratia marcescens

4366341 dbj |BAA02518.l| (D13252) aspartase [Serratia marcescens] SEQ ID n-2954

Contig9 from sp|P37147|FXSA_ECOLI FXSA PROTEIN (SUPPRESSOR OF SEQ ID n° 9667 PL-3324.1 4366719 to 69% F EXCLUSION OF PHAGE T7) gb|AAB36686.1 |

4367207 (U78484) FxsA [Escherichia coli] SΞQ ID n~2563

sp|P0538θ|CH10_ECOLI 10 KD CHAPERONIN (PROTEIN CPN10)— (PROTEIN GROES) pιr||BVECGS chaperonin groES - Escherichia coli pdb ] 1AO | O Chain O,

Crystal Structure Of The Asymmetric Chaperonin

Complex GroelGROES (ADP) 7 pdb ] 1AON | P

Chain P, Crystal Structure Of The Asymmetric

Chaperonin Complex GroelGROES (ADPT7^™ pdb|lAON|Q Chain Q, Crystal Structure Of The

Asymmetric Chaperonin Complex

GroelGROES (ADP) 7 pdb | 1A0N]R Chain R, Crystal

Contig9 from

Structure Of The Asymmetric Chaperonin Complex

SEQ ID n° 9668 PL-5094.1 4367405 to 77%

GroelGROES (ADP) 7 pdb|lAON|S Chain S, Crystal

43676S8

Structure of The Asymmetric Chaperonin Complex

GroelGROES (ADP) 7 pdb|lAON|τ Chain T, Crystal

Structure Of The Asymmetric Chaperonin Complex

GroelGROES (ADP) 7 pdb | 1A0N|U Chain U, Crystal

Structure Of The Asymmetric Chaperonin Complex

GroelGROΞS (ADP) 7 emb | CAA30697.1 | (X07850) groES protein (AA 1-97) [Escherichia coli] gb|AAA97041.l| (U14003) GroES protein

[Escherichia coli] gb|AAC77102.l| (AΞ000487)

GroES, 10 Kd chaperone binds to Hsp60 in près. #N/A sp(P48 17|CH60_SALTI 60 KD CHAPERONIN (PROTEIN

ContigS from

CPN60) (GROEL PROTEIN) gb |AAA85277.1 | (U01039)

SEQ ID n° 9669 PL-274.1 4367748 to 94?

GroΞL [Salmonella typhi] db_] |BAA94286.l|

436S334

(AB033231) groEL [Salmonella typhimurium] SEQ ID n~2943 pir| |B83256 probable transcriptional regulator

PA3124 [imported] - Pseudomonas

ContigS from aeruginosa (strain PAOl)

SEQ ID n° 9670 PL-273.1 4370041 to 67% gb|AAG06512.l|AE004736_9 (AE004736) probable

4370949 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~2932

sp|P39 78|YJΞI_EC0LI HYPOTHΞTICAL 13.1 KD

PROTEIN IN MOPA--EFP- INTERGENIC REGION

PRECURSOR (0128) pir||S56372 hypothetical

Contig9 from protein ol28 - Escherichia coli gb| AAA97043. l| SEQ ID n° 9671 PL-50S7.1 4371733 to 70% (U14003) ORF_ol28 [Escherichia coli]

4372077 gb]AAC77l04.l| (AE000487) orf, hypothetical protein [Ξscherichia coli K12] gb|AAG59343.l|AE005648_5 (AE005648) orf, hypothetical protein [Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG59345.l|AE005648_7 (AE005648) orf,

SΞQ ID n° 3672 PL-272.1 4372137 to m 83% hypothetical protein [Escherichia coli θl57:H7] 4373165 SΞQ ID n~2921 sp|P33398 |EFP_EC0LI ΞLONGATION FACTOR P (EF-P) pir||S34443 translation elongation factor ΞF-P -

Escherichia coli emb| CAA43851.1 | (X61676)

ContigS from elongation factor P [Escherichia coli] SEQ ID n° 3673 PL-3325.1 4373203 to 923 gb|AAA97046.l| (U14003) elongation factor P

4373763

[Escherichia coli] gb| AAC77107.l| (AE000487) elongation factor P (ΞF-P) [Escherichia coli

K12] SEQ ID n~2564 sp|P20928|SUGE_PROVU SUGE PROTEIN HOMOLOG

Contig9 from pir| |S00120 hypothetical protein D - Proteus

SEQ ID n° 9674 PL-3326.1 4373995 to 60% vulgaris emb |CAA 9512.1 | (X06151) put. OrfD (AA 4374309

1-104) [Proteus vulgaris] SEQ ID n~2565

Contig9 from gb|AAC26596.l| (U83995) putative protease

SEQ ID n° 3675 PL-271.1 437449S to m 59% [Porphyromonas gingivalis]

4375383 SEQ ID n~2910

Sp|P20924|FRDD_PROVU FUMARATE RΞDUCTASE 13 KD

Contig9 from

HYDROPHOBIC PROTEIN pir| (RDEB13 fumarate

SEQ ID n° 3676 PL-50S9.1 4375586 to 80% reductase (ΞC 1.3.99.1) 13K protein - Proteus

4375939 vulgaris #N/A

sp|P03805|FRDC_ECOLI FUMARATE REDUCTASΞ 15 KDA

HYDROPHOBIC PROTEIN pir||S56380 succinate _.dehydrogenase (EC 1.3.99.1) frdC - Escherichia coli emb|CAA23535.l| (V00277) unknown gène [Escherichia coli] gb| AAA23439.1| (J01611) gl5

protein [Ξscherichia coli] gb|AAA9705l. l|

Contig9 from - - (U14003) fumarate reductase, membrane anchor

SEQ ID n° 9677 PL-5100.1 4375956 to m 763 polypeptide [Escherichia coli]

4376348 gb|AAC7711 .l| (AE000487) fumarate reductase, anaerobic, membrane anchor polypeptide [Escherichia coli K12] gb|AAG59353.l|AE005648_15 (AΞ005648) fumarate reductase, anaerobic, membrane anchor polypeptide [Escherichia coli 0157 :H7] #N/A sp|P2092l|FRDB_PROVU FUMARATE REDUCTASE IRON-

Contig9 from SULFUR PROTEIN pir| JRDEBIV fumarate reductase SBQ ID n° 9678 PL-270.1 4376365 to -843 (EC 1.3.99.1) iron-sulfur protein - Proteus

4377099 vulgaris emb|CAA29502.l| (X06144) frdB (AA 1-

245) [Proteus vulgaris] SBQ ID n~2899 sp|P209 2|FRDA_PROVU FUMARATE REDUCTASΞ

Contig from FLAVOPROTΞIN SUBUNIT pir( | RDEBF fumarate SΞQ ID n° 9679 PL-269.1 4377092 to m 91% reductase (ΞC 1.3.99.1) flavoprotein - Proteus

4378888 vulgaris emb| CAA23501. l| (X06144) frdA (AA 1-

538) [Proteus vulgaris] SΞQ ID n-2887

Contig9 from dbj |BAB06239.l[ (AP001515) transposase related SEQ ID n° 9680 PL-268.1 4379827 to 21% protein (20) [Bacillus halodurans]

4380852 SΞQ ID n~2876 Contig9 from SΞQ ID n° 9681 PL-5104.1 4381170 to No Hits found

4381583 #N/A

pir||S56383 lysine--tRNA ligase (ΞC 6.1.1.6) genx - Ξscher-ichia coli gb|AAA97054.11 (U14003)

—

SEQ ID n° 968

0157:H7] SEQ ID n~2865 gb|AAG57370.l|AΞ005456_7 (AE005456)

Contig9 from glycerophosphodiester phosphodiesterase,

SEQ ID n° 9683—-BL--266.-1 4383142 to m 84% periplasmic [Escherichia coli

4384218 0157:H7] SEQ ID n~2855

Contig9 from gb |AAG5737i . ι |AΞ005456_8 (AΞ005456) sn-glycerol-

SEQ ID n° 9684 PL-265.1 4384398 to 913 3 -phosphate permease [Ξscherichia coli

4385750 0157. -H7] SEQ ID n~2846

Contig9 from ref |NP_052313.l| ORF C8 [Ralstonia solanacearum]

SΞQ ID n° 9685 PL-3327.1 4386254 to 553 --dbj |BAA32221.l| (AB015669) ORF C8 [Ralstonia

4386685 solanacearum] SEQ ID n~2566 pir| |B82736 hemolysin-type calcium binding protein XF1011 [imported] - Xylella

Contig9 from fastidiosa (strain 9a5c) SEQ ID n° 9686 PL-264.1 4387112 to 30% gb|AAF83821.l|AE003938_12 (AE003938) hemolysin-

4388269 type calcium binding protein [Xylella fastidiosa] SEQ ID n~2836

Contig9 from gb|AAF78381.l|AC069551_14 (AC069551) T10022.22

SΞQ ID n° 9687 PL-3328.1 4388266 to 293 [Arabidopsis thaliana]

4388847 SEQ ID n~2567

Contig9 from sp]P4551l|GLDA_CITFR GLYCEROL DEHYDROGENASE

SEQ ID n° 9688 PL-263.1 4389038 to 723 (GLDH) gb|AAB48844.l| (U09771) glycerol

4390138 dehydrogenase [Citrobacter freundii] SEQ ID n~2825

Contig9 from gb|AAG57917.l|AE005508_8 (AE005508) L-

SEQ ID n° 9689 PL-5108.1 4390335 to 393 fuculokinase [Escherichia coli oi57:H7]

4390577 #N/A

s | P11553 | FUCK_ΞCOLI L-FUCULOKINASE pir | | KIECFK fucokinase (ΞC 2.7.1.52) - Ξscherichia coli

ContigS from emb|CAA33128.l| (X15025) fucK ORF (AA 1-482)

SEQ ID n° 9630 PL-5109.1 43S0711 to 603 [Ξscherichia coli] gb] AAB40453.l] (U29581) L- 43S0953 fuculose kinase [Ξscherichia coli]

gb|AAC75845.l| (AE000364) L-fuculokinase

[Escherichia coli K12] #N/A

Contig9 from

SEQ ID n° 9691 PL-5110.1 4391089 to m No Hits found 4391268 #N/A Contig9 rrom^" gb|AAG57919.l|AΞ005508_10 (AΞ005508) positive

SΞQ ID n° 9692 PL-3329.1 4391316 to p 803 regulator of the fuc operon [Escherichia coli 4391768 0157 :H7] SEQ ID n~2568 Contig9 from gb|AAC26596.l| (U83995) putative protease

SEQ ID n° 9693 PL-26 .1 4391765 to m 59% [Porphyromonas gingivalis] 4392649 SEQ ID n-2814 Contig9 from gb|AAG58580.l|ÀË005570__7 (AE005570) orf,

SEQ ID n° 9694 PL-261.1 4392946 to m 71% hypothetical protein [Escherichia coli 0157:H7] 4393620 SEQ ID n~2803 sp|P37618 |YHHP_ECOLI HYPOTHETICAL 9.1 KDA

PROTEIN IN FTSY-NIKA INTERGΞNIC RΞGION pir]|s47689 hypothetical 9. IK protein (ftsY-nikA

Contig9 from intergenic région) - Ξscherichia coli

SEQ ID n° 9695 PL-5111.1 4393805 to 803 gb|AAB18445.l| (U00039) No définition line found

4394059 [Bscherichia coli] gb| AAC764S5.1 [ (AE000423) orf, hypothetical protein [Escherichia coli K12] gb|AAG58573.l|AE005570__6 (AΞ005570) orf, hypothetical protein [Ξscherichia coli 0157 :H7] #N/A

Contig9 from emb|CAA04762.l| (AJ001437) putative P-type

SEQ ID n° 9696 PL-260.1 4394209 to m 76% cation-translocating membrane ATPase 4396494 [Proteus mirabilis] SEQ ID n~2792

sp|P37616|YHHN_ΞCOLI HYPOTHΞTICAL 23.8 KD

PROTEIN IN FTSY-NIKA INTERGENIC REGION (0208)

ContigS fro pir| S47687 hypothetical protein o208 -

SEQ ID n° 9697 PL-259.1 4396639 to m 693 Escherichia coli gb| AAB18443.l| (U00039) No

4397265 définition line found [Ξscherichia coli]

gb|AAC76493.l| (AE000422) putative enzyme [Escherichia coli K12] ^"~ SEQ ID n-2782 pir| |S47685 hypothetical protein ol30 -

Contig9 from

Escherichia coli gb | AAB18441.1] (U00039) SEQ ID n° 9698 PL-5113.1 4397536 to m 64% overlaps previous ORF, probably uses downstream 4397817 start [Fscherichia cόTi] #N/A

Contig9 from gb|AAG58574.l|AΞ005570_l (AΞ005570) orf,

SEQ ID n° 9699 PL-258.1 4397841 to 743 hypothetical protein [Escherichia coli 0157 :H7]

4398425 SΞQ ID n~2771

ContigS from gb|AAG58573.l[AΞ005563_13 (AΞ005569) cell

SEQ ID n° 3700 PL-257.1 43S8585 to 85% division membrane protein [Escherichia coli

43SS853 0157:H7] SEQ ID n-S.761 sp|P10115|FTSE_ΞCOLI CΞLL DIVISION ATP-BINDING

PROTBIN FTSΞ pir| | CEΞCFE cell division ATP- bindmg protein ftsE - Ξscherichia coli emb ]CAA27985. l| (X04398) ORF 2 (AA 1-222); 25 kD

(put. ftsΞ) [Ξscherichia coli] gb| AAB18438.1 |

ContigS from (U00039) CG Site No. 736 [Bscherichia col ]

SΞQ ID n° 3701 PL-256.1 43S9866 to 893 gb|AAC76488.l| (AE000422) ATP-binding component

4400531 of a membrane-associated complex involved in cell division [Ξscherichia coli K12] gb|AAG58572.l|AE005569_12 (AE005569) ATP-binding component of a membrane-associated complex involved in cell division [Escherichia coli

0157:H7] SEQ ID n~2751

Contig9 from gb | AAG58571. l | AE005569_ll (AΞ005569) cell

SΞQ ID n° 3702 PL-255.1 4400524 to 77% division membrane protein [Ξscherichia coli

4401498 0157:H7] SEQ ID n~2740

Contig9 from

SEQ ID n° 3703 PL-5115.1 4401628 to m No Hits found

4401876 #N/A

sp]P50508]RP32_ENTCL RNA POLYMERASE SIGMA-32

Contig9 from FACTOR pir | |S60165- transcription initiation SEQ ID n° 9704 PL-254.1 4401935 to p 943 factor sigma 32 - Enterobacter cloacae

4402792 dbj |BAA09440.l| (D50829) sigma-32 homolog

[Enterobacter cloacae] SΞQ ID n~2729

sp ] P42100 | GRK BACSU GLYCERATΞ KINASE pir| |A70071 conserved hypothetical protein yxaA

Contig9 from Bacillus subtilis dbj |BAA21580.l| (AB005554) SEQ ID n° 9705 PL-253.1 4402889 to 71% homologs are found in E. coli and H. influenzae;

4404028 see SWISS_PROT ACC#: P42100 [Bacillus subtilis] emb|CAB16041.l| (Z99124) similar to hypothetical proteins [Bacillus subtilis] SEQ ID n~2718

Contig9 from gb|AAG58566.l|AE005569_6 (AΞ005569) orf, SEQ ID n° 9706 PL-5116.1 4404016 to 56% hypothetical protein [Escherichia coli 0157 :H7]

4404414 #N/A pir| |BLECL leucine-specific binding protein precursor - Escherichia coli gb | AAB18433.1 [

Contig9 from (U00039) CG Site No. 550 [Escherichia coli] SEQ ID n° 9707 PL-252.1 44047S4 to 823 gb|AAC76483.l| (AE000421) high-affinity leucine-

4405S06 specific transport system,- periplasmic binding protein [Escherichia coli

K12] SEQ ID n~2707 pir] [S47676 livH protein - Escherichia coli pir| IQRECLH leucine transport protein livH -

Escherichia coli gb|AAB18432.l| (U00039) CG

Site No. 552 [Escherichia coli] gb | AAC76482.1 |

Contig9 from (AEO00421) high-affinity branched-chain amino

SEQ ID n° 9708 PL-251.1 4405968 to 87% acid transport system,- membrane

4406894 component [Escherichia coli K12] gb]AAG58564.l|AE005569_4 (AE005569) high- affinity branched-chain amino acid transport System; membrane component [Ξscherichia coli 0157:H7] SEQ ID n~2696

Contig9 from gb|AAG58563.l|AE005569_3 (AE005569) high-

SΞQ ID n° 9709 PL-250.1 4406891 to 803 affinity branched-chain amino acid transport

4408168 [Ξscherichia coli 0157 :H7] SEQ ID n~2685

sp|P30293|LIVG_SALTY HIGH-AFFINITY BRANCHED- CHAIN AMINO ACID TRANSPORT ATP-BINDING ^ Contig9 from_ _PROTΞIN LIVG (LIV-I_PROTΞIN_G)__pir.|_|_JH.Q_6.70_high

SEQ ID n° 9710 PL-249.1 4408165 to 82% affinity branched-chain amino acid transport LIV

4408938 I system LivF protein - Salmonella

_ typhimurium dbj |BAA02131.l| (D12589) LivF protein [Salmonella typhimurium] SΞQ ID n~£673

Contig9 from gb|AAG58561.l]AΞ005569_l (AE00556S) ATP-binding SEQ ID n° 9711 PL-248.1 4408941 to p 843 component of leucine transport [Escherichia 4409642 coli 0157 :H7] SΞQ ID n~2662

Contig9 from SΞQ ID n° 9712 PL-5118.1 4410745 to No Hits found

4411146 #N/A Contig9 from gb|AAC63079.l[ (AF035423) putative juvénile SEQ ID n° 9713 PL-247.1 4411176 to 553 hormone esterase [Leptinotarsa

4412435 decemlineata] SEQ ID n-2651 pir| |C82481 transcription—regulator AraC/XylS family VCA0266 [imported] - Vibrio

Contig9 from cholerae (group Ol strain N16961) SEQ ID n° 9714 PL-246.1 4412695 to m 623 gb|AAF96177.l| (AE004366) transcriptional

4413474 regulator, AraC/XylS family [Vibrio cholerae] SΞQ ID n~£640 pir| |D82481 multidrug résistance protein D

ContigS from VCA0267 [imported] - Vibrio cholerae SEQ ID n° 3715 PL-245.1 4413578 to p 64? (group 01 strain N16961) gb | AAF36178.1 |

4414741 (AE004366) multidrug résistance protein D

[Vibrio cholerae] SEQ ID n~262S

sp|P11028|FIS_ECOLI DNA-BINDING PROTEIN FIS

(FACTOR-FOR-INVERSION STIMULATION PROTEIN)

_XHIN_RE_CQMBINATIONAL ENHANCER BINDING PROTEIN.)_ pir| |DNECFS DNA-binding protein fis -

Escherichia coli pir| |B56267 fis protein -

Salmonella typhimurium pdb | 1ΞTY | A Chain A, The

Crystal Structure of Ξ. Coli Wild-Type Fis pdb|lETY|B Chain B, The Crystal Structure Of E.

Coli Wild-Type Fis pdb|lFIA|A Chain A, Fis

Protem (Factor For Inversion Stimulation)

Cσntig9 from pdb|lFlA|B Chain B, Fis Protein (Factor For SEQ ID n^» 9716 PL-5120.1 4415217 to m 773 Inversion Stimulation) pdb|3FIs|A Chain A, Fis

4415513 Protein (Factor For Inversion Stimulation) pdb|3FIs|B Chain B, Fis Protein (Factor For

Inversion Stimulation) gb|AAA83856.l| (J03245)

Hin recombinational enhancer binding protein - [Escherichia coli] gb|AAA38812.1]

(J03816) factor-for-inversion protein

[Escherichia coli] gb| AAA23783.l| (MS5784) 'Fis

ORF start' [Escherichia coli] gb| AAA63020.1 |

(U03101) Fis [Salmonella typhimurium] gb|AAA58065.l| (U18997) CG Site No. 18328

[Ξscherichia coli] gb|AAC76293.l| (AΞ000405) #N/A

Contig9 from gb|AAC77884.l| (AF040379) yhdG homolog [Proteus

SEQ ID n° 9717 PL-244.1 4415539 to 88% vulgaris]

4416504 SEQ ID n~2619 sp|P28637|PRMA_ECOLI RIBOSOMAL PROTΞIN LU

METHYLTRANSFERASE pir| |B43924 ribosomal protein

Contig9 from

LU methyltransferase (EC 2.1.1.-) - Ξscherichia

SEQ ID n° 9718 PL-243.1 4416788 to 84% coli gb[AAB28769.l| (S67010) ribosomal protein

4417678

LU methyltransferase; PrmA [Escherichia coli] SEQ ID n~2608

pir| |D65118 pantothenate permease [validated] -

Escherichia coli -gb|AAA58061.l| (U18997) pantothenate permease [Ξscherichia coli]

— — - Contig9^~frσπr gb|AAC76290.l| (AE000404) sodium/pantothenate

SEQ ID n° 9719 PL-242.1 4417721 to m 85% symporter [Escherichia coli K12]

4419172 gb|AAG58386.l|AE005553_8 (AE005553) sodium/pantothenate symporter [Ξscherichia coli

0157 :H7] SEQ ID n~2597

Contig9 from gb|AAG58385.l|AΞ005553_7 (AΞ005553) orf,

SEQ ID n° 9720 PL-5121.1 4419156 to 75% hypothetical protein—[Ξscherichia coli 0157 :H7]

~44Î9398~ #N/A pir| |F81419 probable efflux protein Cj 0035c

ContigS from

[imported] - Campylobacter πejuni

SEQ ID n° 9721 PL-241.1 4420093 to 47%

(strain NCTC 11168) emb|CAB72528.l| (AL139074)

4421280 putative efflux protein [Campylobacter jejuni] SEQ ID n~î586

Contig9 from

SEQ ID n° 9722 PL-5122.1 4421319 to p No Hits found

4421492 #N/A

Contig9 from gb|AAG00942.l|AF272977_2 (AF272977) transposase

SEQ ID n° 9723 PL-240.1 4421600 to 29% [Mycoplasma hyopneumoniae]

4423216 SEQ ID n~î575 pir] |B70567 probable mhpE protein -

Contig9 from

Mycobacterium tuberculosis (strain H37RV) SEQ ID n° 9724 PL-239.1 4423222 to 363 emb|CAB08693.l] (Z95390) mhpB [Mycobacterium

4424031 tuberculosis] SEQ ID n~2563

Contig9 from

SEQ ID n° 9725 PL-238.1 4424028 to No Hits found

4424771 SEQ ID n~2553 sp Q48806|DLPA_LEGPN DLPA PROTEIN pir] j S61390

Contig9 from dlpA protein - Legionella pneumophila

SEQ ID n° 9726 PL-237.1 4424768 to 363 gb|AAA79904.ι| (U07940) DlpA [Legionella

4426933 pneumophila] SEQ ID n~2542 sp Q48806|DLPA_LEGPN DLPA PROTEIN pir| |S61390

Contig9 from dlpA protein - Legionella pneumophila SΞQ ID n° 9727 PL-236.1 4426855 to 553 gb|AAA79904.l| (U07940) DlpA [Legionella

4427610 pneumophila] SEQ ID n~2532

pir||C69122 hypothetical protein MTH1911 -

Contig9 from

Methanobacterium thermoautotrophicum

SBQ ID n° 9728 PL-235.1 4427607 to 353 J[Strain Delta H) gb |AAB86371.1_|—(-AEOO-0942)-

4428488^{^} unknown [Methanothermobacter thermautotrophicus] SΞQ ID n~2521 ref [NP_073225.l| ransposase of IS630 [Salmonella

enterica serovar Choleraesuis] db_j_|BAA01531.l|

Contig9 from

(D10689) M5 protein [Salmonella choleraesuis]

SEQ ID n° 9729 PL-234.1 4429534 to 36% dbj |BAB20556.l| (AB040415) ransposase of IS630

4430586

[Salmonella enterica serovar

Choleraesuis] SEQ ID n~2510 sp|P24182|ACCC_ECOLI BIOTIN CARBOXYLASE (A SUBUNIT OF ACΞTYL-COA CARBOXYLASΞ (ACC) pir| | JS0632 acetyl-CoA carboxylase (ΞC 6.4.1.2) biotin carboxylase chain [validated] -

Escherichia coli pdb[lDVi|A Chain A, Structure Of Biotin Carboxylase (Apo) pdb|lDVl|B Chain B,

Structure Of Biotin Carboxylase- (Apo) pd | IBNC |A Chain A, Mol_ιd: 1; Molécule: Biotin

Contig9 from

Carboxylase; Chain: A, B; Bc:

SEQ ID n° 9730 PL-232.1 4431061 to m 943

6.3.4.14 pdb | IBNC |B Chain B, Mol_id: 1; 4432410

Molécule: Biotin Carboxylase; Chain: A, B; Ec:

6.3.4.14 gb|AAA23409.l| (M80458) biotin carboxylase [Bscherichia coli] gb| AAA23746.1 | (M83198) biotin carboxylase [Ξscherichia coli] gb|AAA58059.l] (U18997) biotin carboxylase [Escherichia coli] gb |AAC76288. l| (AE000404) acetyl CoA carboxylase, biotin carboxylase subunit [Escherichia coli K12] SEQ ID n~2488

sp|P02905|BCCP_ΞCOLI BIOTIN CARBOXYL CARRIBR PROTΞIN OF-ACETYL-COA CARBOXYLASB (BCCP) pir] ]BKΞC9 acetyl-CoA carboxylase (EC_6.4.1.2) biotin carboxyl carrier protein

[validated] - Escherichia coli emb|CAA32933.l|

(X14825) Acetyl-CoA carboxylase (AA 1 - 156)

[EscT-ër£chia^"cό^'lI]^" gb|AAA23408.l| (M80458) biotin carboxyl carrier protein [Ξscherichia

Contig9 from coli] gb|AAA23744.l| (M32214) biotin carboxyl

SΞQ ID n° 9731 PL-3331.1 4432423 to 71% carrier protein (fabΞ) [Ξscherichia coli]

4432893 gb | AÂA23745.1 | (M83198) biotin carboxyl carrier^" protein [Ξscherichia coli] gb] AAA58058. l|

(U18997) biotin carboxyl carrier protein

[Escherichia coli] gb| AAC76287.l| (AΞ000404) acetylCoA carboxylase, BCCP subunit; carrier of biotin [Bscherichia coli K12] gb|AAG58383.l|AE005553_5 (AE005553) acetylCoA carboxylase, BCCP subunit,- carrier of biotin

[Ξscherichia coli 0157 :H7] SEQ ID n~2570

Contig9 from gb|AAD10235.l| (AF011408) type II 3- SΞQ ID n° 9732 PL-3332.1 4432923 to m 743 dehydroquinase [Aeromonas salmonicida subsp .

4433375 salmonicida] SEQ ID n~2571 sp|P26646| HDH_FCOLI PROTEIN YHDH pir|| S0688 hypothetical 35K protein (fabE 5' région) -

Contig9 from Ξscherichia coli gb| AA23407.l| (M80458) 35 kDa

SΞQ ID n° 9733 PL-231.1 4433585 to 71% protein [Ξscherichia coli] gb|AAA58056.1 |

4434562 (U18997) 0RF_o324; orf of ECOACOAC [Escherichia coli] gb|AAC76285.l| (AΞ000404) putative dehydrogenase [Ξscherichia coli K12] SEQ ID n~2478 pir| |BVECEB rod shape-determining protein envB -

Bscherichia coli gb | AAA58054. l| (U18997)

Contig9 from frameshifts changes start relative to ECOMREB

SΞQ ID n° 9734 PL-230.1 4435064 to 92% [Escherichia coli] gb|AAC76283.1]

4436167 (AΞ000404) regulator of ftsi, penicillin binding protein 3, septation function

[Ξscherichia coli K12] SEQ ID n~2467

Contig9 from gb|AAG58377.l|AE005552_7 (AE005552) rod shape- _SEQ ID n° 9735 PL-229.1 4436279 to p 75% determining protein [Escherichia coli 0157 :H7]

4437313 SEQ ID n~2455 sp|P16927 |MRED_ΞCOLI ROD SHAPΞ-DΞTΞRMINING PROTΞIN MRED pir||JV0060 rod shape-determining

protein mreD - Ξscherichia coli gb|AAA24156.l|

(M31792) MreD protein gtg start codon)

Contig9 from [Ξscherichia coli] gb|AAA58052. l] (U18S97) mreD SΞQ ID n° 9736 PL-3333.1 4437313 to p 82%

[Escherichia coli] gb|AAC76281.1 | (AΞ000404)

4437801 rod shape-determining protein [Ξscherichia coli

K12] gb|AAG58376.l|AΞC055^"52_6 (AE005552) rod shape-determining protein [Escherichia coli

0157:H7] SEQ ID n~2572

Contig9 from gb]AAA58051.l| (U18997) ORF_f217; orfΞ of SΞQ ID n° 9737 PL-3334.1 4437967 to p 71% ECMRΞD, uses 2nd start [Ξscherichia

4438554 coli] SEQ ID n~2573 pir| |A65117 cytosolic axial filament protein cafA - Ξscherichia coli gb |AAA58050. l| (U18997)

0RF_f495; orfF of ECMRED, uses 2nd start

Contig9 from

[Ξscherichia coli] gb] AAC76279.l| SΞQ ID n° 9738 PL-228.1 4438551 to p 923

(AE000404) bundles of cytoplasmic filaments

4440020

[Ξscherichia coli K12] gb|AAG58374. l]AΞ005552_

(AEO05552) bundles of cytoplasmic filaments

[Escherichia coli θl57:H7] SEQ ID n~2444

Contig9 from gb|AAG58373.l|AE005552_3 (AΞ005552) Z4604 gène SΞQ ID n° 9739 PL-227.1 4440068 to p 62% product [Escherichia coli 0157 :H7]

4443862 SEQ ID n~2433 pir| |F82325 conserved hypothetical protein

Contig9 from VC0421 [imported] - Vibrio cholerae SΞQ ID n° 9740 PL-226.1 4443859 to p 61% (group 01 strain N16961) gb] AAF3353 .1 |

4444716 (AEO04129) conserved hypothetical protein

[Vibrio cholerae] SEQ ID n~2422

sp|P46473]TLDD_ΞCOLI TLDD PROTΞIN pir||F65116 tldD-protein - Ξscherichia coli (strain K-12)

Contig9 from gb|AAA58046.l| (U18997) ORF_f481 [Ξscherichia

SEQ ID n° 9741 PL-225.1 4444722 to 903 coli] dbj |BAA07913.l| (D44451) TldD protein 4446167 [Escherichia coli] gb| AAC76276.1 | (AE000403)

suppresses inhibitory activity of CsrA

[Escherichia coli K12] SEQ ID n~2411 pdb|lBNE|C Chain C, Barnase A43cS80C DISULFIDE

Contig9 from

MUTANT pdb|lBNE|B Chain B, Barnase A43cS80C SEQ ID n° 9742 PL-3335.1 4446210 to p 46%

DISULFIDE MUTANT pdb|lBNE|A Chain A, Barnase _ 4446674

A43CS80C DISULFIDE MUTANT SΞQ ID n~2574 sp|P4648θ|YHCO_ECOLI HYPOTHETICAL 10.8 KD

PROTEIN IN ARGR-CAFA INTERGΞNIC REGION (F90) pir| |A65116 hypothetical protein b3239 -

Contig9 from Escherichia coli (strain K-12) gb |AAA58041. l| SEQ ID n° 9743 PL-5130.1 4446679 to p 61% (U18997) ORF_f90; small but good stats

4446948 [Escherichia coli] gb| AAC76271.l| (AE000403) orf, hypothetical protein [Escherichia coli K12] gb|AAG58367.l|AE005551_10 (AE005551) orf, hypothetical protein [Escherichia coli 0157 :H7] /A sp|P26650 |YJGA_ΞCOLI HYPOTHETICAL 21.4 KD

PROTEIN IN FBP-PMBA INTERGENIC REGION (X96

PROTEIN) (F183) pir||S56460 hypothetical 21.4K protein (fbp-pmba intergenic région) -

Escherichia coli gb|AAA24760.l| (M95096) X96

Contig9 from [Escherichia coli] gb|AAA97131. l| (U14003)

SEQ ID n° 9744 PL-224.1 4446980 to m 743 alternate gène name yjgA [Escherichia coli] 4447519 dbj |BAA07914.l| (D44452) 2IK protein

[Escherichia coli] gb| AAC77191.1 | (AE000494) putative alpha hélix protein [Escherichia coli

K12] gb|AAG59431.l|AE005655_10 (AΞ005655) putative alpha hélix protein [Escherichia coli

0157 :H7] SEQ ID n~2400

sp|P2423l|pMBA_ΞCOLI PMBA PROTEIN (TLDE PROTΞIN) pir| |S13730 pmbA protein - Ξscherichia coli emb|CAA38091. l| (X54152) pmbA is involved in the production of antibiotic MccB17 [Escherichia coli] gb|AAA97132. l| (U14003) pmbA

Contig9 from

[Escherichia coli] dbj |BAA07915.1 | (D44452)

TldE protem H:Ξschê^"r e5hia^" coli] gb JAAC77192.l|

4449061 (AE000494) maturation of antibiotic MccB17, see tld gènes [Escherichia coli K12] gb|AAG59432.l]AΞ005655_ll (AΞ005655) maturation of antibiotic MccB17, see tld gènes

[Bscherichia coli 0157 :H7] SΞQ ID n~2389

Contig9 from SEQ ID n° 9746 PL-5132.1 4449263 to p No Hits found

4449613 #N/A ref ]NP_043500.l| orf29 [Bacteriophage HPl] sp|P51733 |-Y029_BPHP1 HYPOTHBTICAL 44.2 KD

Contig9 from

PROTΞIN IN LYS 3'RΞGION (0RF29) pir||S69537 SΞQ ID n° 9747 PL-5133.1 4449725 to p 46% hypothetical protein 29 - phage HPl

4450141 gb|AAB09216.l| (U24159) orf29 [Bacteriophage

HPl] #N/A ref |NP_043501.l| orf30 [Bacteriophage HPl] sp|P51734|YO30_BPHPl HYPOTHBTICAL 20.8 KD

Contig9 from

PROTΞIN IN LYS 3'RΞGION (ORF30) pir|]S69538 SEQ ID n° 9748 PL-3336.1 4450236 to p 543 hypothetical protein 30 - phage HPl

4450790 gb|AAB03217.l[ (U24159) orf30 [Bacteriophage

HPl] SBQ ID n~2575 ref | NP_043502 . l | orf31 [Bacteriophage HPl]

Contig9 from sp|P51735 |VPH_BPHP1 PROBABLE TAIL FIBER PROTEIN SEQ ID n° 9749 PL-222.1 4450800 to p 28% (ORF31) pir||S69539 hypothetical protein 31 -

4452608 phage HPl gb|AAB09218.l| (U24159) orf31

[Bacteriophage HPl] SΞQ ID n~2378

Contig9 from ref |NP_037719.1 | Gp29 [Bacteriophage HK97] SΞQ ID n° 9750 PL-5134.1 4452608 to p 33% gb] AAF31112.1 | (AF069529) Gp29 [Bacteriophage

4452880 HK97] #N/A

sp|P77699|TFAD_ECOLI TAIL FIBΞR ASSΞMBLY PROTΞIN

HOMOLOG FROM-LAMBDOID PROPHAGE DLP12 Contig9 from pir| |G6 788 ybcX protein, phage protein-related •

SΞQ ID n° 9751 PL-5135.1 4452922 to 603 Escherichia coli gb| AAB40757.1 | (U82598)

4453224 hypothetical protein [Escherichia coli]

gb|AAC73662.l| (AE000161) orf, hypothetical protein [Escherichia ceDlï^"κ 2^"] #N/À

ContigS from

SEQ ID n° 9752 PL-5136.1 4453223 to No Hits found

4453381 #N/A ref |NP_043504.l| orf33 [Bacteriophage HPl] sp|P51737|Y033_BPHPl HYPOTHETICAL 28.3 KD

Contig9 from

PROTEIN IN LYS 3 'REGION (ORF33) pir||S69541

SEQ ID n° 9753 PL-221.1 4453344 to 423 hypothetical protein 33 - phage HPl

4453952 gb|AAB09220.l| (U24159) or 33 [Bacteriophage

HPl] SEQ ID n~2367 ref |NP_043505.l] orf34 [Bacteriophage HPl]

Sp|P51738 |Y034_BPHP1 HYPOTHBTICAL 20.8 KD

ContigS from

PROTΞIN IN LYS 3 ' REGION (ORF34) pir| |S69542

SEQ ID n° 9754 PL-3337.1 4453S42 to 55% hypothetical protein 34 - phage HPl

4454460 gb|AAB09221.l[ (U24159) orf34 [Bacteriophage

HPl] SΞQ ID n~2576 ref |NP_043506.l| orf35 [Bacteriophage HPl] sp|P51739|Y035_BPHPl HYPOTHETICAL 58.7 KD

Contig9 from

PROTEIN IN LYS 3 ' REGION (ORF35) pir||S69543

SEQ ID n° 3755 PL-220.1 4454460 to 59% hypothetical protein 35 - phage HPl

4456109 gb|AAB09222.l| (U24153) orf35 [Bacteriophage

HPl] SΞQ ID n~2357 pir[ |F81815 Ner-like DNA-binding protein NMA1883

[imported] - Neisseria meningitidis

Contig9 from (group A strain Z2431) emb| CAB71360.l] SΞQ ID n° 9756 PL-5138.1 4457112 to m 51% (AJ331256) putative DNA-binding protein

4457237 [Neisseria meningitidis] emb| CAB85106.1 |

(AL162757) Ner-like DNA-binding protein

[Neisseria meningitidis Z24S1] #N/A

sp|P18837|SFSB_BCOLI SUGAR FΞRMΞNTATION

STIMULATION_.._.PROTEIN B (NER-LIKΞ PROTΞIN) pir| |BVECNP nlp protein - Escherichia coli emb|CAA48736.l| (X68873) Ner-like protein, homologous to Ner protein of

bacteriophages Mu and D108 [Escherichia coli]

- - - - Contig9^""from ^" —gb|AAA57989. l| (U18997) Ner-like protein SEQ ID n° 9757 PL-5139.1 4457253 to 453 [Escherichia coli] gb|AAC76220.l| (AE00039S)

4457381 regulatory factor of maltose metabolism; similar to Ner repressor protein of phage Mu

[Ξscherichia coli K12] ^{"" "} gb[AAG58322.l|AE005547_8 (AΞ005547) regulatory factor of maltose metabolism; similar to

Ner repressor protein of phage Mu [Escherichia coli 0157 :H7] #N/A

Contig9 from

SEQ ID n° 9758 PL-5140.1 4457438 to No Hits found

4457587 #N/A sp|P40679|RNK_ΞCOLI RΞGULATOR OF NUCLΞOSIDΞ

DIPHOSPHATE KINASE pir || 157917 nucleoside diphosphate kinase regulator - Escherichia coli gb|AAC36933.l| (L37900) rnk gène product

[Escherichia coli] dbj |BAA35239.l| (D90701) Rnk protein [Escherichia coli] dbj |BAA35248.l |

Contig9 from

(D90702) Rnk protein [Ξscherichia coli]

SΞQ ID n° 9759 PL-3339.1 4458122 to m 693 gb|AAB40810.l| (U82598) regulator of nucleoside

4458532 diphosphate kinase [Ξscherichia coli] gb|AAC7 711.l| (AE000166) regulator of nucleoside diphosphate kinase [Ξscherichia coli K12] gb|AAG54945.l|AE005240_ll (AE005240) regulator of nucleoside diphosphate kinase

[Escherichia coli 0157 :H7] SEQ ID n~2577

sp|P33996|PTSO_ΞCOLI PHOSPHOCARRIER PROTΞIN NPR

(NITROGΞN RΞLATED HPR) pir] ] 176722 phosphocarrier protein Npr (nitrogen related hpr) - Escherichia coli emb[CAA816 1.l| (Z27094) ORFV [Ξscherichia coli]

gb]AAB60167.l| (U12684) NPr [Escherichia coli] gb| AAA58008.l| ^"(u 89^""9^"7T^""similar to nitrogen- related HPr phosphocarrier protein of

Contig9 from the phosphotransferase system, Swiss-Prot SEQ ID n^» 9760 PL-5141.1 4458721 to m 62? Accession Number P33996 [Escherichia

4458 3 ^~ coli] gb|AAC7623^""8 r| fAEO^~O0400) phosphocarrier protein HPr-like NPr, nitrogen related, exchanges phosphate with Ξnzy e I, Hpr

[Ξscherichia coli K12] gb|AAG58340.l| EO05548_11 (AEO05548) phosphocarrier protein HPr-like NPr, nitrogen related, _exchanges phosphate with

Enzyme I, Hpr [Escherichia coli

0157 :H7] #N/A

Sp|P17163 |YHBJ_KLΞPN HYPOTHΞTICAL 32.5 KD

Contig9 from PROTEIN IN PTSN-PTSO INTERGENIC REGION (ORF4) SΞQ ID n° 9761 PL-219.1 4458993 to m 95% pir||S60666 probable ATP-binding protein -

4459844 Klebsiella pneumoniae emb|CAA90684. l| (Z50803) orfiv [Klebsiella pneumoniae] SEQ ID n~2345 gb|AAG58338.l|AΞ005548_3 (AE005548)

Contig9 from phosphotransferase system enzyme IIA, régulâtes SEQ ID n° 9762 PL-3340.1 4459928 to m 84%

N metabolism [Ξscherichia coli

4460335

0157 :H7] SEQ ID n~2579 sp | P1716l ] RP5M_KLEPN PROBABLE SIGMA ( 54)

Contig9 from MODULATION PROTEIN (ORFS5) pir | | S07660 SEQ ID n° 9763 PL-5142.1 4460519 to m 82? hypothetical protein 95 (rpoN 3 ' région) -

4460806 Klebsiella pneumoniae emb ] CAA3 391. l | (X16335 )

0RF95 peptide (AA 1-95) [Klebsiella pneumoniae] #N/A

gb|AAG58336.l|AE005548_7 (AE005548) RNA

Contig9 from polymerase, sigma (54 or 60) factor,- nitrogen and SEQ ID n° 9764 PL-218.1 4460830 to m fermentation régulation [Escherichia coli 4462272

^{~ ~} 0157 :H7] SEQ ID n~2334 pir| |C65111 probable ABC transporter (ntrA/rpoN

5' région) - Escherichia coli (strain

- K^l^)^{^} gb|AAA58003.11 (U18997)^""0RF_o241

Contig9 from [Escherichia coli] gb|AAC76233.l| (AΞ000399) SEQ ID n° 9765 PL-217.1 4462300 to m 91% putative ATP-binding component of a transport

4463025 System [Escherichia coli K12] gb|AAG58335.l|AE005548_6 (AEO055 8)—putative ATP binding component of a transport system

[Escherichia coli 0157 :H7] SEQ ID n~2323

Sp|P38685|YHBN_ECOLI PROTEIN YHBN PRECURSOR pir| (B65111 17.3 kD protein in rpoN 5' égion precursor (orf185) - Ξscherichia coli

(strain K-12) gb| AAB60161.1 | (U12684 orfl85

Contig9 from

[Bscherichia coli] gb|AAA58002.1 | (U18937)

SEQ ID n° 9766 PL-3341.1 4463032 to m 71%

0RF_ol85 [Ξscherichia coli] gb| AAC76232.l]

4463565

(AΞ0003S9) orf, hypothetical protein

[Ξscherichia coli K12] gb]AAG5833 . l| E005548_5

(AEO05548) orf, hypothetical protein

[Escherichia coli 0157 :H7] SEQ ID n~2580 sp|P453S7|YRBK_ΞCOLI HYPOTHΞTICAL 21.7 KD

PROTΞIN IN MURA-RPON INTΞRGΞNIC RΞGION (0191) pir| |A65111 hypothetical 21.7 kD protein in murZ rpoN intergenic région - Ξscherichia

Contig9 from coli (strain K-12) gb|AAA58001.l| (U18997)

SEQ ID n° 9767 PL-3342.1 4463546 to m 723

0RF_ol91 [Ξscherichia coli] gb | AAC76231.1 |

4464124

(AΞ000399) orf, hypothetical protein

[Ξscherichia coli K12] gb|AAG58333. l|AΞ005548_4

(AE005548) orf, hypothetical protein

[Escherichia coli 0157:H7] SΞQ ID n~2581

sp|P45396]YRBI_ΞC0LI HYPOTHΞTICAL 20.0 KD

PROTEIN IN MURArRPON INTERGΞNIC RΞGION

SEQ ID n° 9768 PL-3343

hypothetical protein [Escherichia coli 0157:H7] SΞQ ID n~2582

Contig9 from gb|AAG58331.l|AE005548_2 (AΞ005548) putative

SEQ ID n° S763 PL-215.1 4464726 to 863 isomerase [Ξscherichia coli 0157 :H7]

4465694 SΞQ ID n~2301

Contig9 from gb|AAG58330.l|AE005548_l (AE005548) orf,

SEQ ID n° 9770 PL-214.1 4465719 to m 623 hypothetical protein [Escherichia coli 0157 :H7]

4466693 SΞQ ID n~2290 sp| P45393 |YRBF_ECOLI HYPOTHETICAL ABC TRANSPORTER ATP-BINDING PROTEIN IN MURA-RPON INTERGΞNIC REGION pir| |E55110 hypothetical protein b3195 - Escherichia coli (strain K-12)

Contig9 from gb|AAA57996.l| (U18997) ORF_f269 [Escherichia

SΞQ ID n° 9771 PL-213.1 4466922 to 87% coli] gb|AAC76227.l| (AΞ000399) putative ATP-

4467725 binding component of a transport system [Ξscherichia coli K12] gb|AAG58329.l|AE005547_15 (AΞ005547) putative ATP-binding component of a transport system [Ξscherichia coli 0157 :H7] SΞQ ID n~2279 sp]P45392|YRBB_ΞC0LI HYPOTHETICAL 27.9 KD PROTEIN IN MURA-RPON INTERGENIC REGION (F260) pir] |D65110 hypothetical 27.9 kD protein in murz rpon intergenic région - Escherichia

Contig9 from coli (strain K-12) gb| AAA57995. l| (U18937)

SΞQ ID n° 9772 PL-212.1 4467736 to 89% ORF_f260 [Escherichia coli] gb|AAC76226.1 |

4468518 (AE0003S9) orf, hypothetical protein [Escherichia coli K12] gb|AAG58328.l|AΞ005547_14 (AE005547) orf, hypothetical protein [Ξscherichia coli 0157 :H7] SEQ ID n~2268

sp|P4539l|YRBD_ΞCOLI HYPOTHΞTICAL 19.6 KD PROTΞIN IN MURA-RPON INTERGENIC REGION PRECURSOR (F183) pir||C65H0 hypothetical

Contig9 from protein b3193 - Escherichia coli (strain K-12) SEQ ID n° 9773 PL-3345.1 4468523 to 77% gb|AAA579S4.l| (U18997) ORF_fl83 [Escherichia

4469029 coli] gb|AAC75225.l] (AE000399) orf, hypothetical ^"protein [Escherichia coli K12] gb|AAG58327.l]AE005547_13 (AE005547) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~2583 s | P45390 | YRBC_ECOLI HYPOTHBTICAL 24.0 KD

PROTEIN IN MURA-RPON INTERGENIC REGION

PRECURSOR (F211) pir||B65110 hypothetical 24.0 kD protein in murZ-rpoN intergenic région -

ContigS from

Escherichia coli (strain κ-12) gb|AAA57993. l|

SEQ ID n° 9774 PL-211.1 4463063 to 84%

(U18997) 0RF_f211 [Ξscherichia coli]

4469692 gb|AAC76224.l| (AE000399) orf, hypothetical protein [Escherichia coli K12] gb|AAF21249.l|AF053073_2 (AF053073) YrbC

[Shigella flexneri] SΞQ ID n~2257

Conti 9 from gb|AAG58325.l|AΞ005547_ll (AE005547) yrbB gène

SEQ ID n° 9775 PL-5145.1 4469694 to 553 product [Ξscherichia coli 015 :H7]

4469987 #N/A

Contig9 from sp|P4378l|YRBA_ECOLI 9.5 KDA PROTEIN IN MURZ-

SΞQ ID n° 9776 PL-5146.1 4470386 to 833 RPON INTERGΞNIC RΞGION

4470640 #N/A

sp|P33038|MURA_ΞNTCL UDP-N-ACETYLGLUCOSAMINE 1- CARBOXYVINYLTRANSFΞRASΞ (ΞNOYLPYRUVATΞ TRANSFERASE) (UDP-N-ACETYLGLUCOSAMINE

ENOLPYRUVYL TTRRAANNSSFFEERRAASSEE)) (EPT) pir||S22372 UDP-N-acetylglucosamine 1-

Contιg9 from

carboxyvinyl ransferase (ΞC 2.5.1.7) -

SEQ ID n° 9777 PL-210.1 44706S2 to 923

— -Enterobacter cloacae pdb|lNAW|A Chain A7 ^~

4471957

Enolpyruvyl Transferase pdb|lNAW|B Chain B,

Enolpyruvyl Transferase emb| CAA77856.1 |

(Z11835) UDP-N-acetylglucosamine 1-

^""carboxyvinyltransferase [Enterobacter- cloacae] SEQ ID n~£247

Contιg9 from gb[AAC08739.l[ (AF021839) 4-hydroxyphenylacetic

SEQ ID n° 9778 PL-20S.1 4472382 to 883 acid hydroxylase [Photorhabdus

4473941 luminescens] SEQ ID n~2235

Contιg9 from

SEQ ID n° 3773 PL-3347.1 4474045 to No Hits found

4474533 SEQ ID n~2584 pir| |S72284 DNA-directed RNA polymerase (EC

Contig9 from 2.7.7.6) beta' -2 chain - Plasmodium

SEQ ID n° 3780 PL-208.1 4474700 to m 26% falciparum plastid emb|CAA64574.l| (X95275)

4477195 frameshift [Plasmodium falciparum] SEQ ID n~2224

Contig9 from gb|AAC72032. l| (AF047554) unknown [Myxococcus

SEQ ID n° 9781 PL-207.1 4477204 to xanthus]

4478646 SEQ ID n~2213

Contιg9 from

SΞQ ID n° 9782 PL-7084.1 4478704 to No Hits found

4478817 #N/A

sp|P31137|DΞGS_ΞCOLI PROTEASE DΞGS PRECURSOR pir| | C6052 trypsin-like proteinase (ΞC 3.4.21.-

) hhoB - Escher±chia-JcoU—gb|AAC43993.11

Contig9 from (U15661) HhoB [Bscherichia coli] gb| AAA58037.1 | SEQ ID n° 9783 PL-206.1 4479433 to m 79% (U18997)

4480491 gb | AAC44006.11_

gb| AAC76267.l| (AΞ000402) protease [Ξscherichia coli K12] prf | |2206396B hhoB gène [Bscherichia coli] SΞQ ID n~£202

Contig9 from sp | Q05459 |VAΘc^SALDU-VIRULΞNCE-ASSOCIATED SEQ ID n° 9784 PL-5150.1 4481353 to m 82% PROTEIN VAGC

4481541 #N/A ref |NP_052816.l| pXOl-120 [Bacillus anthracis]

Contig9 from pir| |H59105 hypothetical protein pXOl-120 - SEQ ID n° 3785 PL-3348.1 4481746 to 593 Bacillus anthracis virulence plasmid

4482318 pXOl gb|AAD32424.l|AAD32424 (AF065404) pXOl-120

[Bacillus anthracis] SEQ ID n~2585

Contig9 from dbj |BABl603l.l| (AB030747) transposase SEQ ID n° 9786 PL-205.1 4482435 to p 42%

[Streptococcus pyogenes]

4483139 SEQ ID n~2191 sp|P390S9|DEGQ_ECOLI PROTEASE DEGQ PRECURSOR pir| ] JC6051 trypsin-like proteinase (ΞC 3.4.21.-

) hhoA precursor - Escherichia coli

Contig9 from gb|AAC43992.l| (U15661) HhoA [Escherichia coli] SEQ ID n° 9787 PL-204.1 4483291 to 833 gb|AAA58036.l| (U18997) ORF_o455 [Escherichia

4484667 coli] gb|AAC44005.l| (U32495) DegQ [Escherichia coli] gb]AAC76266.l| (AΞ000402) serine endoprotease [Escherichia coli K12] prf | (2206396A hhoA gène [Escherichia coli] SEQ ID n~2180

sp|P39436|YHCB_EC0LI HYPOTHETICAL 15.2 KD — PROTEIN IN RPLM-HHOA INTERGΞNIC REGION (0134) _pir |-|C65115 hypothetical 15.2 kD._proteixr jι_rplM^_. _ hhoA intergenic région -

Contig9 from coli (strain K-12) gb | AAA58035.1 | (U18997)

SEQ ID n° 9788 PL-5154.1 4484905 to m 72% ORF_ol34 [Escherichia coli] gb] AAC76265.1]

-- — -- 4485309

(AΞ000402) orf, hypothetical protein

[Escherichia coli K12] gb | AAG58361.l|AE005551_4

(AΞ005551) orf, hypothetical protein

[Ξscherichia coli 0157:H7] __^ #N/A sp]P46442 |YHCM_ECOLI HYPOTHΞTICAL 43.1 KD

PROTΞIN IN RPLM-HHOA INTERGENIC REGION (F375) pir| |B65115 hypothetical 43.1 kD protein in rplM- hhoA intergenic région - Escherichia

Contig9 from coli (strain K-12) gb] AAA58034.l| (U18997)

SEQ ID n° 9789 PL-203.1 4485653 to 73%

ORF_f375 [Escherichia coli] gb|AAC76264.l|

4486783

(AΞ000402) orf, hypothetical protein

[Escherichia coli K12] gb] AAG58360.1 |AE005551_3

(AE005551) yhcM gène product [Ξscherichia coli

0157 :H7] SEQ ID n~2 sp|P0241θ|RL13_ECOLI 50S RIBOSOMAL PROTEIN L13 pir| |R5ΞC13 ribosomal protein L13 [validated] - Ξscherichia coli emb|CAA26041.l| (X02130) L13

(rplM) (aa 1-129) [Ξscherichia coli]

Contig9 from gb|AAA58033.l| (U18997) 50S ribosomal subunit SEQ ID n° 9790 PL-5156.1 4487038 to 97% protein L13 [Ξscherichia coli] gb|AAC76263.l|

4487466

(AΞ000402) 50S ribosomal subunit protein L13

[Ξscherichia coli K12] gb|AAG58359.l|AΞ005551_2

(AE005551) 50S ribosomal subunit protein L13

[Escherichia coli 0157 :H7] #N/A

sp|P02363|RS9_ECOLI 30S RIBOSOMAL PROTEIN S9 pir| |R3EC9 ribosomal protein S9 [validated] -

Ξsche_ή.chia_cΩl.i emb|CAA26042.l| (X02130) S9

(rpsl) (1-130) [Escherichia coli]

Contig9 from gb|AAA58032.l| (U18997) 30S ribosomal subunit

SEQ ID n° 9791 PL-5158.1 4487482 to 953 protein S9 [Escherichia coli] gb|AAC76262. l| -8^-8^-4

(AΞ000402) 30S ribosomal subunit protein S9

[Escherichia coli K12] gb | AG58358.1 | AΞ005551_1

(AΞ005551) 30S ribosomal subunit protein S9

[Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG01334.l|AF288218_l (AF288218) SspA

SΞQ ID n° 9792 PL-202.1 4488221 to 89% [Providencia stuartii]

4488862 SEQ ID n~2159 sp|P25663 |SSPB_ECOLI STRINGENT STARVATION PROTEIN B pir| [JS0666 stringent starvation protein B, SspB - Escherichia coli gb|AAA24650.l| (M69028) stringent starvation

Contig9 from protein [Escherichia coli] gb|AAA58030.1 |

SEQ ID n° 9793 PL-3351.1 4488866 to 783 (U183S7) stringent starvation protein B

4489381 [Ξscherichia coli] gb | AAC76260. l| (AE000402) stringent starvation protein B [Bscherichia coli

K12] gb|AAG58356.l|AΞ005550_9 (AE005550) stringent starvation protein B [Escherichia coli

0157:H7] SEQ ID n~2588

Contig9 from

SEQ ID n° 9794 PL-3352.1 4489433 to m No Hits found

4489951 SΞQ ID n~2589

Contig9 from gb|AAG58347.l|AE005549_4 (AΞ005549) glutamate

SEQ ID n° 9795 PL-201.1 44S0178 to 893 synthase, small subunit [Ξscherichia coli

4431596 0157 :H7] SΞQ ID n~214S

sp|P0983l|GLTB_ΞCOLI GLUTAMATE SYNTHASE [NADPH]

LARGE CHAIN PRECURSOR (GLUTAMATE -SYNTHASE

ALPHA SUBUNIT) (NADPH-GOGAT) (GLTS ALPHA CHAIN)

Contig9 from pir||F65112 glutamate synthase (NADPH) (EC

SEQ ID n° 9796 PL-200.1 4491606 to m 89% 1.4.1.13 ) large chain precursor -

4496114 Escherichia coli gb |AAA58014. l| (U18997) glutamate synthase, large subunit [Ξscherichia coli] gb|AAC76244.l| (AΞ000400) glutamate synthase, large subunit [Ξscherichia coli K12] SΞQ ID n~2138

Contig9 from SEQ ID n° 9797 PL-199.1 44S6811 ^~tô^~ 843 emb|CAA37397.l| (X53315) arcB [Ξscherichia coli]

4499156 SΞQ ID n~2125 Contig9 from sp | 26428 | LBB_ECOLI ENHANCING LYCOPΞNE SΞQ ID n° 9798 PL-198.1 4499394 to 77% BIOSYNTHESIS PROTEIN 2 (SIGMA CROSS-REACTING

4500047 PROTEIN 27A) (SCRP-27A) SΞQ ID n~2114 sp|P46022|MTGA_ECOLI MONOFUNCTIONAL BIOSYNTHETIC

PΞPTIDOGLYCAN TRANSGLYCOSYLASΞ

(MONOFUNCTIONAL TGASE) pir] |B65112 hypothetical

Contig9 from

27.3 kD protein in ptsO-arcB intergenic région - SEQ ID n° 9799 PL-197.1 4500052 to 73%

Escherichia coli (strain K-12) gb|AAA58010.1 |

4500777

(U18997) ORF_f242 [Escherichia coli] gb|AAC76240.l| (AΞ000400) putative peptidoglycan enzyme [Escherichia coli K12] SEQ ID n~2103

Sp|P45467 |YRAP_ECOLI HYPOTHETICAL 20.0 KD PROTEIN IN AGAI-MTR INTΞRGΞNIC REGION PRECURSOR (OISl) pir||B65105 hypothetical 20.0 kD protein in agai-mtr intergenic région -

ContigS from Ξscherichia coli (strain K-12) gb|AAA57953.1 |

SEQ ID n° 9800 PL-136.1 4500909 to 74%

(U18997) ORF_ol91 [Escherichia coli]

4501484 gb|AAC76184.l| (AΞ000396) putative periplasmic protein [Escherichia coli K12] gb|AAG58286.l|AΞ005543_16 (AΞ005543) putative periplasmic protein [Ξscherichia coli 0157 :H7] SΞQ ID n~2092

sp|P45466|YRA0_EC0LI HYPOTHETICAL 21.1 KDA

PROTEIN IN AGAI-MTR INTERGENIC REGION (0136) p.ir_]_]_A6_5_l05 phosphoheptose isomerase homologie

ContigS from Escherichia coli (strain K-12) gb | AAA57352. l|

SEQ ID n° 3801 PL-3353.1 4501495 to m 91% (U18397) ORF_ol96 [Escherichia coli]

4502085 gb|AAC76183.l] (AΞ000396) orf, hypothetical protein [Escherichia coli K12] gb|AAG58285.l|AΞ005543_15 (AE005543) orf, hypothetical protein [Escherichia coli 0157 :H7] SΞQ ID n~2590

Sp|P45465]YRAN_EC0LI HYPOTHETICAL 14.8 KDA

PROTΞIN IN AGAI-MTR INTΞRGΞNIC RΞGION (0131) pir] |H65104 hypothetical 14.8 kD protein in agai-

ContigS from mtr intergenic région - Ξscherichia SEQ ID n° 3802 PL-5161.1 4502110 to m 563 coli (strain κ-12) gb|AAA5795l.l| (U18997)

4502430

0RF_ol31,- overlaps o678, other starts possible

[Ξscherichia coli] gb| AAC76182.1 | (AΞ000396) orf, hypothetical protein [Escherichia coli K12] #N/A sp|P45464|YRAM_ECOLI HYPOTHETICAL 72.8 KD

PROTEIN IN AGAI-MTR INTERGΞNIC RΞGION (0678) pir| |G65104 hypothetical 72.8 kD protein in agai-

ContigS from mtr intergenic région - Escherichia

SEQ ID n° 9803 PL-195.1 4502567 to m 58% coli (strain K-12) gb|AAA57950.1 | (U18997)

4504360

0RF_o678 [Escherichia coli] gb| AAC76181.l|

(AE000396) putative glycosylase [Escherichia coli K12] SΞQ ID n~2081 sp|P45528]YRAL_ΞCOLI HYPOTHΞTICAL 31.3 KD

PROTΞIN IN AGAI-MTR INTΞRGΞNIC RΞGION (F286) pir| |F65104 hypothetical 31.3 kD protein in agai- mtr intergenic région - Ξscherichia

Contig9 from coli (strain K-12) gb|AAA57949.l| (U18997)

SEQ ID n° 3804 PL-134.1 4504373 to 84%

ORF_f 86 [Escherichia coli] gb ]AAC76180.1 |

4505239

(AΞ000395) orf, hypothetical protein

[Ξscherichia coli K12] gb|AAG58282.l|AE005543_12 (AE005543) orf, hypothetical protein [Ξscherichia coli 0157 :H7] SEQ ID n~£071

pir| |G81001 hypothetical protein NMB2137

Contig9 from [imported] - Neisseria meningitidis SΞQ ID n° 9805 PL-5162.1 4505481 to _.433 (group B strainJ_iπ5_8_l____gb_|_AAF42445.l] (AΞ002562)

4505624 hypothetical protein [Neisseria meningitidis

sp|P42624|YHAK ΞCOLI HYPOTHETICAL 25.9 KD

PROTEIN IN EXUR-TDCC INTERGENIC RΞGION (0233) pir| |G65099 hypothetical 25.9 kD protein in exuR

Contig9 from tdcC intergenic région - Escherichia SΞQ ID n° 9806 PL-192.1 4505735 to 703 coli (strain K-12) gb|AAA57910.l] (U18997) 4506436

ORF_o233 [Fscherichia coli] gb | AAC76141.1 ]

(AΞ0003S2) orf, hypothetical protein

[Escherichia coli K12] SEQ ID n~2050 sp|P4 623|YHAJ_ECOLI HYPOTHΞTICAL

TRANSCRIPTIONAL REGULATOR IN EXUR-TDCC

INTERGENIC REGION pir||F65099

Contig9 from hypothetical -transcription regulator exuR-tdcC SΞQ ID n° 9807 PL-191.1 4506547 to 863 intergenic région - Escherichia coli

4507443 (strain K-12) gb | AAA57909.1 [ (U18997) ORF_f298

[Ξscherichia coli] gb| AAC76140.l| (AΞ000392) putative transcriptional regulator LYSR-type

[Escherichia coli K12] SEQ ID n~2039

Contig9 from gb|AAG58234.l|AE005539_ll (AE005539) orf, SΞQ ID n° 9808 PL-5164.1 4508114 to m 81% hypothetical protein [Escherichia coli 0157 :H7]

4508509 #N/A Contig9 from gb|AAG58233.l]AE005539_10 (AE005539) orf, SΞQ ID n° 9809 PL-5165.1 4508729 to 39% hypothetical protein [Escherichia coli 0157 :H7]

4508989 #N/A sp|P42618|YQJE_ECOLI HYPOTHETICAL 15.1 KD

PROTEIN IN EXUR-TDCC INTERGENIC REGION pir| |H65098 hypothetical protein yqjE -

Contig9 from

Ξscherichia coli (strain K-12) gb|AAC76l3 .l| SΞQ ID n° 9810 PL-5166.1 4508982 to m 73?

(AΞ000332) orf, hypothetical protein

4509383

[Ξscherichia coli K12] gb| AAG58232. l| AΞ005539_9

(AE005539) yqjE gène product [Escherichia coli

0157 :H7] #N/A

sp|P42617|YQJD_ECOLI HYPOTHETICAL 11.1 KD

PROTEIN IN EXUR-TDCC INTERGENIC REGION

. pir| |G65098 hypothetical 11.1—kD_prQ_tein_in_exuR _ tdcC intergenic région - Ξscherichia

Contig9 from coli (strain K-12) gb|AAA57902.1 | (U18997) SEQ ID n° 9811 PL-5167.1 4509385 to m 66?

ORF_olθl [Escherichia coli] gb]AAC76133 ,l| = 4509690

(AE000392) orf, hypothetical protein

[Ξscherichia coli K12] gb | AAG58231.l|AE005539_8

(AE005539) orf, hypothetical protein

[Escherichia coli 0157 :H7] #N/A sp|P42614|YQJA_EC0LI HYPOTHΞTICAL 24.6 KDA

PROTΞIN IN ΞXUR-TDCC INTΞRGΞNIC RΞGION pir| |D65098 hypothetical protein b3095 -

Contig9 from Ξscherichia coli (strain K-12) gb| AAA57899.l|

SΞQ ID n° 9812 PL-190.1 4509885 to m 85% (U18997) ORF_o220 [Escherichia coli] 4510556 gb|AAC76130.l| (AΞ000391) orf, hypothetical protein [Escherichia coli K12] gb|AAG58228.l|AΞ005539_5 (AΞ005539) orf, hypothetical protem [Escherichia coli 0157 :H7] SEQ ID n~2028

ContigS from gb|AAG58221.l|AE005538_8 (AE005538) putative

SΞQ ID n° 9813 PL-189.1 4511208 to p 73% transport protein [Escherichia coli 0157 :H7] 4512170 SEQ ID n-2016 sp|P42602|YGJU_ECOLI HYPOTHΞTICAL SYMPORTΞR YGJU pir| |F65097 hypothetical 43.5 kD protein in ebgC exuT intergenic région - Ξscherichia coli (strain K-12) gb|AAA57891.l| (U18997)

ContigS from

ORF_o414; Geneplot suggests frameshift near

SΞQ ID n° 9814 PL-188.1 4512587 to p 83% start but none found [Escherichia 4513834 coli] gb|AAC76124.l| (AE000391) putative transport protein [Escherichia coli K12] gb]AAG58222.l|AE005538_9 (AE005538) putative transport protein [Ξscherichia coli 0157 :H7] SEQ ID n~2005

Contig9 from gb|AAG58214.l|AE005538_l (AE005538) putative

SEQ ID n° 9815 PL-187.1 4513954 to m 77% NADPH dehydrogenase [Ξscherichia coli 0157 :H7] 4515975 SΞQ ID n~994

Contig9 from gb|AAC03422.l| (U81516) unknown [Myxococcus SEQ ID n° 9816 PL-186.1 4516369 to 54% xanthus] 451696.8 SEQ_ID_n___a_8 sp|P75829|YBJX_EC0LI HYPOTHΞTICAL 38.4 KDA PROTEIN IN AQPZ-CSPD INTERGENIC REGION

Contig9 from pir| ]E64826 ybj protein - Ξscherichia coli

SEQ ID n° 9817 PL^185— 1 45^"17022 to 58% gb] AAC73964.1 | (AE000189) putative enzyme

4517957 [Escherichia coli K12] dbj |BAA35595.1 | (D90725)

VirK protein [Escherichia coli] SEQ ID n~974 sp | Q9X7Q6 | IDI_STRCO PROBABLE ISOPENTENYL-

DÎPHOSPHATE^{^}DELTA-ISOMERASE (IPP ISOMERASET

Contig9 from (ISOPENTENYL PYROPHOSPHATE ISOMERASΞ) SEQ ID n° 9818 PL-3354.1 4518535 to 523 pιr| |T35275 probable IPP isomerase -

4519068 Streptomyces coelicolor emb(CAB40700.l|

(AL049587) putative IPP isomerase [Streptomyces coelicolor A3 (2) ] SEQ ID n~2591

Contig9 from gb|AAD02882.l| (AF104220) gamma-tocopherol SΞQ ID n° 9819 PL-184.1 451S206 to 26% methyltransferase [Arabidopsis

4520150 thaliana] SEQ ID n~S63 ref |NP_043506.l| orf35 [Bacteriophage HPl] sp | 51739 | Y035_BPHP1 HYPOTHETICAL 58.7 KD

ContigS from

PROTEIN IN LYS 3 'REGION (ORF35) pir||S69543 SΞQ ID n° S820 PL-183.1 4520271 to 52% hypothetical protein 35 - phage HPl

4521200 gb|AAB09222.l| (U24159) orf35 [Bacteriophage

HPl] SΞQ ID n~952

ContigS from SΞQ ID n° 9821 PL-5173.1 4521427 to m No Hits found

4521603 #N/A ContigS from SΞQ ID n° 9822 PL-5175.1 4521802 to m No Hits found

4521891 #N/A Contig9 from SΞQ ID n° 9823 PL-5176.1 4521945 to No Hits found

4522046 #N/A

sp|P37668|YIAG_ECOLI HYPOTHETICAL 11.0 KD

PROTEIN IN BISC-CSPA INTΞRGΞNIC REGION (036) pir||S47776 hypothetical 11K protein (bisC-cspA

Contig9 from intergenic région) - Escherichia coli SΞQ ID n° 9824 PL-5177.1 4522214 to m 423 gb|AAB18532.l| (U00039) No définition line found

4522510 [Escherichia coli] gb| AAC76579.1 | (AEO 00433) orf, hypothetical protein [Escherichia coli K12] gb|AAG58704.l|AE005582_7 (AΞ005582) orf, hypothetical protein [Escherichia coli 0157 :H7] #N/A pir| |D82455 hypothetical protein VCA0468

Contig9-from - _ _ _

[imported] - Vibrio cholerae (group SEQ ID n° 9825 PL-5178.1 4522558 to m 53%

01 strain N16961) gb | AAF96372.1 | (AΞ004379)

4522881 hypothetical protein [Vibrio cholerae] #N/A

Contig9 from gb|AAG55918.1 | AΞ005325_11 (AΞ005325) putative SEQ ID n° 9826 PL-182.1 4523265 to p 45% antirepressor protein encoded by prophage

4523837 CP-933N [Ξsσherichia coli 0157 :H7] SΞQ ID n~942 sp|P07336|RPSD_SALTY RNA- OLYMΞRASΞ SIGMA FACTOR

Contig9 from RPOD (SIGMA-70) pir] |RNΞBST transcription SEQ ID n° 9827 PL-181.1 4524660 to m 90% initiation factor sigma 70 - Salmonella

4526504 typhimurium gb| AA27242.1 | (M14427) rpoD protein [Salmonella typhimurium] SEQ ID n~932 sp|P02923|PRIM_ECOLI DNA PRIMASE pir]|RYEC2 DNA primase (ΞC 2.7.7.-) - Escherichia coli gb|AAA24600.l| (J01687) DNA primase [Escherichia

Contig9 from coli] gb|AAA89146.l| (U28379) CG Site No. 847; SΞQ ID n° 9828 PL-180.1 4526675 to m 81% alternate gen name dnaP, parB

4528420 [Escherichia coli] emb| CAA23531. l| (V00274) DNA primase [Ξscherichia coli] gb|AAC76l02. ι| (AE000388) DNA biosynthesis; DNA primase

[Escherichia coli K12] SEQ ID n~92l

sp|P02379|RS21_ΞCOLI 30S RIBOSOMAL PROTBIN S21 pir| |R3ΞC21 ribosomal protein S21 [validated] -- Ξscherichia coli pir| |R3EB21 ribosomal protein S21 - Salmonella typhimurium emb| CAA23635. l|

(V00346) coding séquence [Escherichia coli]

gb|AAA24599 ,l| (J01687) ribosomal protein S21

Contig9 from

[Escherichia coli] gb|AAA272 0.l| (M14427^") rpsU

SEQ ID n° 9823 PL-5173.1 4528541 to m 933 protein [Salmonella typhimurium] gb|AAA89145.l|

4528756

(U28379) 30S ribosomal subunit protein S21

[Escherichia coli] gb| AAC76101.1 | (AE000388)

30S ribosomal subunit protein S21 [Escherichia coli K12] gb|AAG58199.l|AE005535_ll

(AΞ005535) 30S ribosomal subunit protein S21

[Escherichia coli 0157 :H7] #N/A

Contig9 from

SΞQ ID n° 9830 PL-5180.1 4528769 to No Hits found

4528933 #N/A pir||QQECR6 O-sialoglycoprotein endopeptidase

(ΞC 3.4.24.57) - Ξscherichia coli

Contig9 from gb(AAA89144.l| (U28379) 0RF_f337 [Ξscherichia

SEQ ID n° 3831 PL-173.1 4529051 to coli] gb|AAC76100.1 ] (AE000388) putative O-

4530064 sialoglycoprotein endopeptidase [Ξscherichia coli K12] SEQ ID n~909

Sp|P31056 |YGIH_ECOLI HYPOTHETICAL 22.2 KD

PROTΞIN IN BACA-TTDA INTΞRGΞNIC REGION (0205) pir| |A65094 ygiH protein - Escherichia coli

Contig9 from (strain K-12) gb|AAA89139.l] (U28379) alternate

SΞQ ID n° 3832 PL-178.1 4530123 to 783 name ygiH; ORF_o205 [Escherichia coli]

4530779 gb|AAC76095.l| (AE000387) orf, hypothetical protein [Escherichia coli K12] gb|AAG58193.l|AΞ005535_5 (AΞ005535) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~898

pir| |H65033 probable dihydroneopterin aldolase

SEQ ID n° 9833 PL-5182

PROTEIN (PUTATIVE UNDΞCAPRENOL KINASE) pir| |G650S3 bacitracin résistance protein bacA -

Contig9 from

Escherichia coli gb| AAA8S137.l| (U 8373) CG

SEQ ID n° 9834 PL-177.1- —4531413 to 823

Site NO. 2S733 [Escherichia coli] 4532231 gb|AAC76093.l[ (AΞ000387) bacitracin résistance,- possibly phosphorylates undecaprenol

[Escherichia coli K12] SEQ ID n~887 sp|P0696l|CCA_ECOLI TRNA NUCLEOTIDYLTRANSFERASΞ

(TRNA ADΞNYLYLTRANSFERASΞ) (TRNA CCA-

PYROPHOSPHORYLASΞ) (CCA-ADDING ΞNZYMΞ) pir| |RNECTA tRNA adenylyltransferase (EC

ContigS from

2.7.7.25) - Escherichia coli gb| AAA23541.l|

SEQ ID n° 9835 PL-176.1 45322S6 to m 813

(M12788) tRNA nucleotidyltransferase

4533546

[Escherichia coli] gb|AAA89136.l| (U28379) CG

Site No. 933 [Escherichia coli] gb | AAC76092.1 |

(AE000387) tRNA nucleotidyl transferase

[Escherichia coli K12] SEQ ID n~876

Sp|P39202 |YGIM_ECOLI HYPOTHBTICAL 23.1 KD

PROTEIN IN GLNΞ-CCA INTΞRGΞNIC REGION

PRECURSOR pir| |E65093 hypothetical protein in

ContigS from glne-cca intergenic région - Ξscherichia

SEQ ID n° 9836 PL-175.1 4533562 to m 783 coli (strain K-12) (fragment) gb |AAA89135.1 |

4534182

(U28379) alternate name ygiM; ORF_o206 [Ξscheπchia coli] gb| AAC76091.l| (AΞ000387) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~865

s | P308711 YGIF_ECOLI HYPOTHΞTICAL 48. KD

PROTEIN IN GLNE-CCA INTERGΞNIC RΞGION (ORFXΞ)

Contig9 from pir||S37754 ygiF protein—^Escherichάa—coli_

SEQ ID n° 9837 PL-174.1 4534444 to p 533 emb|CAA79891.l| (Z21844) open reading frame

4535382 upstream glnΞ [Ξsσherichia coli] gb| AAC76090.l|

(AE000387) orf, hypothetical protein

[Escherichia coli K12] SEQ ID n~854 sp | P30870 | GLNE_ECOLI GLUTAMATE-AMMONIA-LIGASE

ADENYLYLTRANSFERASΞ (GLUTAMINE-S NTHETASΞ

ADENYLYLTRANSFERASE) (ATASΞ) pir||C65093

— Contig9 from

[glutamate- -ammonia-ligase] adenylyltransferase

SEQ ID n° 9838 PL-173.1 4535416 to p 77%

(ΞC 2.7.7.42) - Ξscherichia coli

4538286 gb|AAC76089.l| (AE000387) adenylylating enzyme for glutamine synthetase [Escherichia coli K12] SEQ ID n~843

Contig9 from gb|AAG58186.l|AE005534_8 (AΞ005534) putative -SEQ ID n° 9839 PL-172.1 4538374 to p 87% kinase [Escherichia coli 0157 :H7]

45397S8 SEQ ID n~832 pir| |H83639 hypothetical protein PA0045

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 9840 PL-171.1 4540388 to p 84% (strain PAOl) gb | AAG03435.1 | AΞ004444_4

4541059 (AEO04444) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~821 pir| |A83640 hypothetical protein PA0046

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 9841 PL-5183.1 4541081 to p 61% (strain PAOl) gb |AAG03436.l|AE004444_5

4541440 (AE004444) hypothetical protein [Pseudomonas aeruginosa] #N/A

Contig9 from gb|AAF42718.l|AF226570_l (AF226570) putative SEQ ID n° 9842 PL-170.1 4541437 to p 62% lipoprotein GNA1162 [Neisseria meningitidis]

4542099 SEQ ID n~810 Contig9 from gb|AAG5818 . l| AΞ005534_4 (AΞ005534) Z4400 gène SEQ ID n° 9843 PL-5184.1 4542179 to m 69 product [Ξscherichia coli 0157:H7]

4542469 #N/A

sp | P24199 | RIBB_BCOLI 3 , 4 -DIHYDROXY-2 -BUTANONB 4 -

PHOSPHATE-SYNTHASΞ (DHBP SYNTHASE) pir||S22364

—3 _r4—dihyd-rox-y-2 -butanone 4 -phosphate synthase——

Escherichia coli emb|CAA47252.l| (X66720) 3,4- dihydroxy-2 -butanone 4-phosphate synthase

j!Echerichia—coli] gb|AAA71879.l| (M77129) lu

— — Contιg9 from gène product [Escherichia coli] gb| AAA69209.1 | SEQ ID n° 9844 PL-169.1 4542929 to 87%

(U28377) 3, 4-dihydroxy-2 -butanone 4-phosphate

4543582 synthase [Escherichia coli] gbjAAC76077.l| (AΞ000386) 3,4 dihydroxy-2 butanone- -phosphate synthase [Escherichia coli K12] gb| AAG58181. l|AΞ005534_3 (AE005534) 3,4 dihydroxy-2-butanone- -phosphate synthase [Escherichia coli 0157 :H7] SEQ ID n~799

Contig9 from gb|AAG58178.l|AΞ005533_ll (AΞ005533) orf,

SΞQ ID n° 9845 PL-168.1 4543777 to 78% _.hypothetical protein [Ξscherichia coli 0157 :H7]

4544562 SEQ ID n~788 pir| |B83043 hypothetical protein PA4816

Contig9 from [imported] - Pseudomonas aeruginosa

SΞQ ID n° 9846 PL-5188.1 4544629 to 51% (strain PAOl) gb |AAG08201.l|AΞ004895_l

4544787 (AΞO04895) hypothetical protein [Pseudomonas aeruginosa] m/A ref |NP_052677.l| unnamed protein product

[Escherichia coli] pir| |T00308 hypothetical protein L7011 - Escherichia coli plasmid p0157

Contig9 from pir| |T42111 hypothetical protein L7011 - SΞQ ID n° 9847 PL-5189.1 4544801 to m 54%

Escherichia coli plasmid p0157 dbj |BAA31827.l|

4545076

(AB011549) unnamed protein product [Ξscherichia coli] gb|AAC70079.l| (AF074613) hypothetical protein [Escherichia coli 0157 :H7] #N/A

- Co

SΞQ ID n° 9848 PL-5190.1 4

[Escherichia coli 0157.-H7] #N/A

Contig9 from dbj |BAB06233.l| (AP001515) transposase related

SEQ ID n° 9849 PL-167.1 4545718 to m 21% protein- (-20-)—[Bac-i-llus halodurans]

4546743 SEQ ID n~Y77 sp|P24136|YGIC_BCOLI HYPOTHΞTICAL 45.0 KD

PROTΞIN IN TOLC-RIBB INTERGENIC REGION (ORFA)

(0386) pir| |S22361 hypothetical protein A -

Escherichia coli gb|AAA71876.1 | (M77123) ORFA

Contig9 from [Ξscherichia coli] gb|AAA69206.1 | (U28377)

SΞQ ID n° 9850 PL-166.1 4546897 to m 883 ORF_o386; alternate-name ygiC; orfA of M77129

4548057 [Escherichia coli] gb|AAC76074.l|

(AE000385) putative synthetase/amidase [Ξscherichia coli K12] gb|AAG58177.l|AΞ005533_10 (AΞ005533) putative synthetase/amidase [Escherichia coli 0157.-H7] SEQ ID n~766

Contig9 from gb|AAG58176.l|AE005533_9 (AΞ005533) orf,

SEQ ID n° 9851 PL-165.1 4548064 to m 75% hypothetical protein [Escherichia coli 0157.-H7]

4548768 SEQ ID n~755 sp | P27842 | YIGF_ECOLI HYPOTHETICAL 14.5 KD

PROTEIN IN CORA-RARD INTERGENIC REGION (F126) pir| |S30707 hypothetical 14.5K protein (corA 3'

ContigS from région) - Escherichia coli gb|AAD15039.1 | SEQ ID n° 9852 PL-3356.1 4549180 to 39%

(L02122) ORF [Escherichia coli] gb | AAA67613.1 |

4549593

(M87049) fl26 [Ξscherichia coli] gb|AAC76820. l|

(AE000457) orf, hypothetical protein

[Escherichia coli K12] SEQ ID n~2592

pir| |T48674 hasA export system outer membrane

Contig9 from protein hasF [validated] - Serratia

SΞQ ID n° 9853 PL-164.1 4549842 to 823 __marcescens emb | CAA67136._11 (X98513) HAS ABC

4551215 exporter outer membrane component [Serratia marcescens]

sp | P366511 ADPP_ECOLI ADP-RIBOSE PYROPHOSPHATASE

(ADP-RIBOSE DIPHOS^'PHATASE) (ADENOSINE^"""

DIPHOSPHORIBOSΞ PYROPHOSPHATASΞ) (ADPR-PPASΞ)

SΞQ._ID n°. 9854 PL-163.1

orf, hypothetical protein [Ξscherichia coli K12] gb|AAG58173.l|AΞ005533_6 (AE005533) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~Y34 sp|P36650|lCC_ECOLI ICC PROTEIN pir||F65090

3 ' , 5 ' -cyclic-nucleotide phosphodiesterase (EC

3.1.4.17) cpdA - Escherichia coli

Contig9 from

(strain K-12) dbj |BAA0398S .l| (D16557) Icc

SΞQ ID n° 9855 PL-162.1 4552316 to 74%

[Escherichia coli] gb | AAC76068. l| (AE000385)

4553155 regulator of lacZ [Escherichia coli K12] gb|AAG58171.l|AE005533_4 (AΞ005533) regulator of lacZ [Ξscherichia coli 0157 :H7] SΞQ ID n~723 sp | P36653 | YQIA_ECOLI HYPOTHETICAL 21.6 KD

PROTEIN IN PARE-ICC INTERGENIC REGION (F1S3) pir] |E650S0 hypothetical 15.2 kD protein in icc

Contig9 from 3 'région - Escherichia coli (strain K-

SΞQ ID n° 9856 PL-161.1 4553284 to 65? 12) gb|AAA63133.l( (U28377) ORF_ l33

4553892 [Ξscherichia coli] gb |AAC76067.1 j (AE000385) orf, hypothetical protein [Ξscherichia coli K12] gb|AAG58170.1 | AE005533_3 (AE005533) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~Y12

sp |P 0083 |PARE_ΞCOLI TOPOISOMΞRASΞ IV SUBUNIT B pir| |D65090 topoisomerase IV subunit (EC 5.99.1.

Contιg9 from

) - Escherichia coli gb | AAA69198.1 | (U28377)

SEQ ID n° 9857 PL-16θrl 45^"53^"9^"65 to p 92% topoisomerase IV subunit [Escherichia coli]

4555860 gb|AAC760S6.l| (AE000385) DNA topoisomerase IV

subunit B [Escherichia coli K12] SEQ ID n~701

Contig9 from gb|AAF90006.l|AF227958_l (AF227958) DNA SEQ ID n° 3858 PL-159.1 4555902 to 90% topoisomerase IV subunit [Serratia marcescens]

4558169 SEQ ID n~889 Contig9 from gb|AAG58154.l|AE005531_7 (AE005531) 1-acyl-sn-

SEQ ID n° 9859 PL-158.1 4558192 to 803 glycerol-3 -phosphate acyltransferase

4558920 [Escherichia coli 0157 :H7] SEQ ID n~878 Co SEQ ID n° 9860 PL- 157.1 4 Co SEQ ID n° 9861 PL-156.1 4

sp|P33196]YGHB_ΞCOLI HYPOTHΞTICAL 24.1 KD

PROTEIN IN METC-SUFI INTERGΞNIC REGION pir| |G65087 hypothetical 24.1 kD protein in metC sufl intergenic région - Escherichia

ContigS from coli (strain K-12) gb| AAA69176.1 | (U28377) SEQ ID n° 9862 PL-155.1 4562159 to m 773

ORF_o219; alternate name yghB [Escherichia coli]

4562830 gb|AAC76045.l| (AΞ000383) orf, hypothetical protein [Escherichia coli K12] gb|AAG58145.l|AE005530_ll (AΞ005530) orf, hypothetical protein [Escherichia coli 0157:H7] SEQ ID n~S45 pir||S74520 hypothetical protein slr0725 -

ContigS from

Synechocystis sp. (strain PCC 6803) SEQ ID n° 3863 PL-3358.1 4562975 to 553 dbj |BAA16672.l| (D30839) hypothetical protein

4563463

[Synechocystis sp.] SEQ ID n~259

ContigS from gb|AAG58259.l|AE005542_l (AΞ005542) putative SEQ ID n° S864 PL-5196.1 4563469 to 543 protease; htrA suppressor protein [Ξscherichia

4563819 coli 0157 :H7] #N/A

Contig9 from gb|AAK02878.l| (AΞ006118) MetC [Pasteurella

SΞQ ID n° 9865 PL- 154.1 4563968 to 79%— multocida]

4565158 SEQ ID n~θ34 sp|P18783|EXBB_ECOLI BIOPOLYMER TRANSPORT EXBB

PROTEIN pir| |BVECXB biopolymer transport exbB

protein - Escherichia coli gb|AAA69173.1 |

(U28377) exbB gène product [Escherichia coli]

Contig9 from gb|AAC76042.l| (AE000383) uptake of

SEQ ID n° 9866 PL-153.1 4565442 to 503 enterochelin; tonB-dépendent uptake of B

4566476 colicins [Escherichia coli K12] gb|AAG58142.l|AEOC)553^"(rir7AE005530) uptake of enterochelin; tonB-dependent uptake of B colicins [Escherichia coli 0157 :H7] SEQ ID n~625 sp|P18784|ΞXBD_BCOLI BIOPOLYMER TRANSPORT EXBD

PROTEIN pir| | BVECΞD biopolymer transport exbD protein - Escherichia coli gb|AAA23733.1 j

(M28819) exbD peptide—[Escherichia coli]

Contig9 from gb|AAA69172.l| (U28377) exbD gène product

SEQ ID n° 9867 PL-5138.1 4566480 to 833 [Escherichia coli] gb|AAC76041.l| (AE000383)

4566905 uptake of enterochelin; tonB-dependent uptake of

B colicins [Escherichia coli K12] gb|AAG58141.l|AΞ005530_7 (AΞ005530) uptake of enterochelin; tonB-dependent uptake of B colicins [Escherichia coli 0157 :H7] #N/A pir] ]T36177 probable DNA-binding protein -

Contig9 from

Streptomyces coelicolor emb| CAB41077.1 |

SEQ ID n° 3868 PL-152.1 4567052 to 433

(AL049645) putative DNA-binding protein

4568167

[Streptomyces coelicolor A3 (2)] SEQ ID n~814

Contig9 from

SEQ ID n° S863 PL-151.1 4568178 to m No Hits found

4568777 SEQ ID n~603

Contig9 from gb|AAG57790.l|AE005497_l (AE005497) putative

SEQ ID n° 3870 PL-150.1 4569111 to m 473 transport protein [Escherichia coli 0157 :H7]

4570349 SEQ ID n~392

Contig9 from gb|AAD55884.l|AF130250_l (AF130250) hypothetical SEQ ID n° 9871 PL-149.1 4570473 to 503 protein [Ralstonia eutropha] 4571366 -SΞQ—ID n~380

Sp|Q9ZFM2 |XYNB_BACST BETA-XYLOSIDASE (1,4 -BETA-D

Contig9 from

XYLAN XYLOHYDROLASE) (XYLAN 1,4-BETA-

SΞQ ID n° 9872 PL-148.1 4571752 to 16% XYLOSIDASE) gb-|AAC98129.l| (AF098273)- beta=—— = ^{"" "} 4573500 xylosidase [Bacillus stearothermophilus] SEQ ID n~369 sp | QSZFM2 | XYNB_BACST BETA-XYLOSIDASE (1,4-BETA-D

Contig9 from XYLAN XYLOHYDROLASE) (XYLAN 1,4-BΞTA- SΞQ ID n° 9873 PL-147.1 4574024 to 153 _ 4575778 XYLOSIDASE) gb |AAC98129.1 | (AF098273) beta- xylosidase [Bacillus stearothermophilus] SEQ ID n~558

Contig9 from ref |NP_052313.l| ORF C8 [Ralstonia solanacearum]

SΞQ ID n° 9874 PL-5203.1 4576278 to 803 dbj |BAA32221.l| (AB015669) ORF C8 [Ralstonia

4576709 solanacearum] #N/A

Contig9 from

SΞQ ID n° 9875 PL-146.1 4576930 to m No Hits found

4577850 SEQ ID n~347

Contig9 from

SΞQ ID n° 9876 PL-3359.1 4577840 to No Hits found

4578409 SEQ ID n~25S5

Contig9 from gb|AAH01342.l|AAH013 2 (BC001342) Unknown

SΞQ ID n° 9877 PL-145.1 4578625 to m 22% (protein for MGC:5623) [Homo sapiens]

4579785 SEQ ID n~336

Contig9 from gb|AAB18117.l] (U73857) hypothetical 34.0 kd

SΞQ ID n° 9878 PL-144.1 4579905 to 87% protein in araJ-aroM intergenic

4580816 région [Escherichia coli] SEQ ID n~S 5 s | Q3ZDF8 | SYK_RICPR LYSYL-TRNA SYNTHETASE

(LYSINΞ--TRNA LIGASΞ) (LYSRS) pir| |D716S4

Contig9 from lysine--tRNA ligase (EC 6.1.1.6) (lysS) RP371 - SΞQ ID n° 9879 PL-143.1 4581022 to 233

Rickettsia prowazekii

4583928 emb|CAA14830.l| (AJ235271) LYSYL-tRNA SYNTHETASΞ

(lysS) [Rickettsia prowazekii] SEQ ID n~514

sp | P53052 | CN16_YEREN 2 ' , 3 ' -CYCLIC-NUCLEOTIDΞ 2 ' - PHOSPHODIESTΞRASΞ PRΞCURSOR pir||S52695 2',3'-

ContigS--f-rom- cyc-lic-nuc-l-eoti-de-2-^!— hosphodiesterase (EC

SEQ ID n° 9880 PL-142.1 4584506 to 81%

4586461

cyclic-nucleotide—2-L_^-phosphodiesterase [Yersinia ₌ enterocolitica] SEQ ID n~303 sp|P44012|RN26_HAEIN PROBABLE RIBONUCLEASE HI0526 PRECURSOR pir| |C64009 ribonuclease

Contig9 from homolog HI0526 - Haemophilus influenzae (strain SEQ ID n° 9881 PL-141.1 ^"4586501 to 45%

Rd KW20) gb|AAC22192.l| (U32735) H.

4587319 influenzae predicted coding région HI0526

[Haemophilus influenzae Rd] SEQ ID n~492 pir| |T35714 hypothetical protein SC7H1.19 -

Contig9 from

Streptomyces coelicolor emb| CAA16206. l| SEQ ID n° 9882 PL-140.1 4587790 to 40% (AL021411) hypothetical protein [Streptomyces

4588395 coelicolor A3 (2)] SEQ ID n~481 pir] ]H83486 probable MFS transporter PA1282

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 9883 PL-139.1 4588435 to 63% (Strain PAOl) gb|AAG04671.l(AE004557_12

4589958 (AE004557) probable MFS transporter [Pseudomonas aeruginosa] SΞQ ID n~469 pir||F83345 probable non-ribosomal peptide synthetase PA2402 [imported] -

Contig9 from Pseudomonas aeruginosa (strain PAOl) SEQ ID n° 9884 PL-138.1 4590504 to 383 gb|AAG05790.l|AΞ004667_l (AΞ004667) probable non-

4591091 ribosomal peptide synthetase [Pseudomonas aeruginosa] SEQ ID n~458

Contig9 from SEQ ID n° 9885 PL-5208.1 4591124 to p No Hits found

4591306 #N/A Contig9 from emb| CAC01604.l| (AJ269505) peptide synthetase SEQ ID n° 9886 PL-137.1 4591564 to 35% [Anabaena sp. 90]

4593417 SEQ ID n~448

Contig9 from

SΞQ ID n° 9887 PL-5211.1 4593419 to No Hits found

4593553 #N/A

Contig9 from dbj |BAB12211.l| (AB032543) polykeitde synthase

SEQ ID n° 9888 PL-136.1 4593604 to 51% and peptide synthetase [Microcystis

4595346 aeruginosa] _ SΞQ ID n~438

Contig9 from

SΞQ ID n° 9889 PL-3361.1 4595476 to No Hits found

4535964 SΞQ ID n~25S7 sp ( 059185 | PYRD_PYRHO ϋlHYDROOROTATE DEHYDROGENASE (DIHYDROOROTATE OXIDASE) (DHODEHASΞ) (DHODASΞ) (DHOD)

Contig9 from pir| |H71027 probable dihydroorotate

SΞQ ID n° 9830 PL-135.1 4596061 to 493 dehydrogenase - Pyrococcus horikoshii

4596930 dbj |BAA30624.l| (AP000006) 303aa long hypothetical dihydroorotate dehydrogenase

[Pyrococcus horikoshii] SEQ ID n~428 pir| |T4425l creatininase (EC 3.5.2.10)

Contig9 from

[validated] - Arthrobacter sp. (strain

SΞQ ID n° 3891 PL-134.1 4596327 to 463

TE1826) dbj |BAA25929.l| (AB007122) creatininase

4537697

[Arthrobacter sp . ] SEQ ID n~417 ref |NP_047874.1 | putative transposase [Yersinia pestis] pir| |T14989 probable transposase -

ContigS from

Yersinia pestis plasmid pMTl gb| AAC82732.l|

SΞQ ID n° 9892 PL-133.1 4599955 to 70%

(AF074611) putative transposase [Yersinia

4600869 pestis] emb|CAB55253.l| (AL117211) hypothetical protein YPMT1.71 [Yersinia pestis] SEQ ID n~406

Contig9 from

SEQ ID n° 9893 PL-5214.1 4600894 to No Hits found

4601190 #N/A

sp|P13458|SBCC_ECOLI EXONUCLEASE SBCC pir| |BVECSC exonuclease (EC 3.1.15.-) sbcC -

SEQ ID n° 9834

prf | |2204364A sbcC gène [Escherichia coli] SEQ ID n~395

ContigS from gb|AAB18122.l| (U73857) exonuclease SbcD SEQ ID n° S8S5 PL-131.1 4604383 to m 723 - [Ξscherichia coli]

^" 4606218 SΞQ ID n~384 sp|P45606|PHOB_SHIDY PHOSPHATE RΞGULON

Contig9 from TRANSCRIPTIONAL RΞGULATORY PROTΞIN PHOB SEQ ID n° 38S6 PL-130.1 4606605 to 873 pir| |A44753 phoB protein - Shigella dysenteriae

4607234 gb|AAA26535.l| (M31793) phosphate regulatory protein phoB [Shigella dysenteriae] SEQ ID n~374

ContigS from gb|AAG54746.l|AE005219_2 (AE005219) positive and SEQ ID n° 9897 PL-129.1 4607318 to 72% négative sensor protein for pho regulon

4608658 [Escherichia coli 0157 :H7] SEQ ID n~362 sp|P3701l|BRNQ_ECOLI BRANCHBD-CHAIN AMINO ACID

TRANSPORT SYSTΞM II CARRIΞR PROTEIN

(LIV-II) pir| |A64759 branched-chain amino acid transport system II carrier protein brnQ

- Escherichia coli gb|AAB18125. l| (U73857)

Contig9 from similar to S . typhimurium brnQ [Escherichia SEQ ID n° 9898 PL-128.1 4609009 to 773 coli] gb|AAC73504.l| (AE000146) branched chain

4610340 amino acid transport system II carrier protein [Escherichia coli K12] gb|AAG54747.l]AΞ005219_3 (AΞ005219) branched chain amino acid transport system II carrier protem [Ξscherichia coli 0157 :H7] SΞQ ID n~351

sp | P36267 | GGT_PSΞSP GAMMA-GLUTAMYLTRANSPEPTIDASE

C -SEQ-ID n° 9899 PL-127.1

[Pseudomonas sp.] SEQ ID n~340

Contig9 from gb]AAK02879.l| (AΞ006118) TsaA [Pasteurella SEQ ID n° 9900 PL-126.1 4612451 to m 923 multocida]

4613053 SΞQ ID n~329 Contig9 from gb|AAG54751.l|AΞ00S2-l-9—-(AΞ005219) putative

SEQ ID n° 9901 PL-125.1 4613338 to m 643 glycoprotein [Ξscherichia coli 0157 :H7] 4613934 SΞQ ID n~318

S | P21516 | QUΞA_ECOLI S-ADENOSYLMΞTHIONINE : TRNA RIBOSYLTRANSFERASE-ISOMERASE (QUΞUOSINE BIOSYNTHESIS PROTEIN QUEA) pir| |B38530 S- adenosylmethionine--tRNA ribosyltransferase- isomerase (EC - 5.4.99.-) queA

[validated] - Escherichia coli gb| AAA16114.1 | (M37702) gueuosine biosynthesis [Escherichia coli] gb|AAB40161.l| (U82664) S-

Contig9 from adenosylmethionine : tRNA ribosyltransferase-

SEQ ID n° 9902 PL-124.1 4614039 to 903 isomerase [Ξscherichia coli]

4615106 gb|AAC73508.l| (AE000147) synthesis of trueuine in tRNA; probably S- adenosylmethionine : tRNA ribosyltransferase- isomerase [Escherichia coli K12] gb]AAG54752.l|AE005220_l (AE005220) synthesis of queuine m tRNA; probably S- adenosylmethionine : tRNA ribosyltransferase- isomerase [Escherichia coli 0157 :H7] SEQ ID n~307 sp|Q54177|TGT_SHIFL QUEUINE TRNA- RIBOSYLTRANSFERASE (TRNA-GUANINE

Contig9 from TRANSGLYCOSYLASE) (GUANINE INSERTION

SEQ ID n° 9903 PL-123.1 4615257 to 93-

ENZYME) (VIRULENCE-ASSOCIATED PROTEIN

4616381 VACC) ό_bj ]BAA05482.l| (D26469) VacC [Shigella flexneri] SΞQ ID n~297

sp|P19677|YAJC_ECOLI HYPOTHETICAL 11.9 KDA PROTEIN IN TGT-SECD INTΞRGΞNIC RΞGION (ORF12) - pir| |P38530 preprotein translocase chain yajc -

Ξscherichia coli gb|AAA24668.1 | (M63939) ORF

[Ξscherichia coli] gb|AAC60468. l| (S68715) YajC

[Escherichia coli, Peptide, 110 aa]

Contig9 from dbj ]BAA05483.l| (D26469) ORF [Shigella ^"flexneri]^"

SΞQ ID n° 9904 PL-5216.1 4616473 to 743 gb|AAB40163.l| (U82664) hypothetical 11.9 kd

4516802 protein [Escherichia coli] gb|AAC73510,l|

(AE000147) orf, hypothetical protein

[Escherichia coli K12] gb|AAG54754^"7T|^'ÂË005220_3

(AΞ005220) orf, hypothetical protein

[Escherichia coli 0157 :H7] prf | |2005253A yacJ protein [Escherichia coli] #N/A

Contig9 from gb|AAD44348.l| (AF163861) SecD protein

SEQ ID n° 9905 PL-122.1 4616830 to 88% [Enterobacter aerogenes]

4618677 SΞQ ID n~286

Contig9 from gb|AAB40l65.l | (U82664) protein-export membrane

SEQ ID n° 9906 PL-121.1 4618688 to 853 protein secF [Escherichia coli]

4619656 SEQ ID n-275 sp|P25538|YBAD_ECOLI HYPOTHΞTICAL 17.2 KD

PROTEIN IN TS -RIBG INTERGENIC REGION (ORFl) pir| |S26200 ybaD protein - Escherichia coli emb|CAA45734.l| (X64395) orfl [Escherichia coli]

Contig9 from gb|AAB40169.l| (U82664) hypothetical 17.2kd SEQ ID n° 9907 PL-3365.1 4619772 to 92% protein [Escherichia coli] gb|AAC73516.l|

4620221

(AE000148) orf, hypothetical protein

[Escherichia coli K12] gb|AAG54762.l|AΞ005220_ll (AE005220) orf, hypothetical protein [Escherichia coli 0157 :H7] SΞQ ID n~2598 gb|AAG54763.l|AE005220_12 (AE005220)

Contig9 from bifunctional pyrimidine deaminase/reductase in

SEQ ID n° 9908 PL-120.1 4620226 to 76% pathway of riboflavin synthesis

4621335

[Escherichia coli 0157 :H7] SEQ ID n~264

Contig9 from gb|AAB40171.l| (U82664) probable riboflavin SEQ ID n° 9909 PL-3366.1 4621462 to . 84% synthase beta ^"chain [Ξscherichia coli]

4621932 SEQ ID n~2599 sp|P0438l|NUSB_BCOLI N UTILIZATION SUBSTANCE

PROTEIN B (NUSB PROTEIN) pir || 151822 nusB

protein - Ξscherichia coli pir||FJΞCB transcription^" termination factor nusB

[validated] - Ξscherichia coli pdb|lΞYl[A Chain A, Solution Structure Of

Escherichia Coli Nusb pdb | 1BAQ |

Antitérmiha^~ti^"δh^~"~Fâctor Nusb From Escherichia

Coli, Nmr, 18 Structures

Contig9 from gb|AAA24228.l| (M26839) nusB [Escherichia coli] SEQ ID n° 9910 PL-5217.1 4621959 to 80% emb|CAA45737.l| (X64395) nusB (ssyB)

4622375

[Ξscherichia coli] emb | CAA25289.1 | (X00681) nusB protein [Escherichia coli] gb| AAB40172.1 |

(U82664) N .utilization substance protein B

[Escherichia coli] gb| AAC7351S .l| (AE000148) transcription termination; L factor [Ξscherichia

COli K12] gb|AAG54765.l|AΞ005221_2

(AΞ005221) transcription termination; L factor

[Escherichia coli 0157 :H7] prf] |2111328A NusB protein [Escherichia coli] #N/A sp | P77785 | THIL_ECOLI THIAMINE-MONOPHOSPHATΞ

KINASE (THIAMINE-PHOSPHATE KINASE) pir | |A64771

Contig9 from thiamin-phosphate kinase (ΞC 2.7.4.16) - SΞQ ID n° 9911 PL-119.1 4622476 to p 80% Escherichia coli gb| AAB40173.1 | (U82664)

4623465 similar to H. influenzae HI1305 [Ξscherichia coli] gb|AAC73520.l| (AΞ000148) thiamin- monophosphate kinase [Ξscherichia coli K12] SΞQ ID n~252

Contig9 from gb|AAG54767.l|AΞ005221_4 (AE005221) SEQ ID n° 9912 PL-3367.1 4623458 to 76% phosphatidylglycerophosphatase [Ξscherichia coli

4623949 0157 :H7] SEQ ID n~2600 Contig9 from ref | NP_053144 .1 | 0RF11 [Yersinia pestis] SEQ ID n° 9913 PL-5220.1 4624229 to 633 gb|AAF05107.l|AF152323_ll (AF152923) 0RF11

4624501 [Yersinia pestis] #N/A

sp|Q 7149JYAFQ_ECOLI HYPOTHETICAL 10.8 KD

-

SΞQ ID n° 9914 PL-5221.1

[Escherichia coli] #N/A

Contig9 from emb|CAA75664.l| (Y15510) transposase SΞQ ID n° 9915 PL-5222.1 4624961 to 573 [Pasteurella_multocida] _ 4625254 #N/A

Contig9 from gb|AAG16999.l|AF184152_2 (AF184152) transposase SEQ ID n° 9916 PL-3368.1 4625260 to m 553 [Piscirickettsia salmonis]

4625760 SEQ ID n~2601 Contig9 from gb|AAG58523.l|AE005564_8 (AE005564) orf; SEQ ID n° 9917 PL-3369.1 4625871 to m 42% hypothetical protein [Escherichia coli 0157 :H7]

4626395 SEQ ID n~2602 Contig9 from gb|AAG58568.l|AΞ005569_8 (AΞ005569) orf; SΞQ ID n° 9918 PL-5223.1 4626392 to m 503 hypothetical protein [Escherichia coli 0157:H7]

4626670 #N/A sp|P77488 |DXS_EC0LI 1-DΞOXYXYLULOSE-5-PHOSPHATE

SYNTHASE (DXP SYNTHASE) pir | |D64771 dxs protein

- Escherichia coli gb|AAB40176.1 | (U82664)

Contig9 from similar to H. influenzae HI1439 [Escherichia SEQ ID n° 9919 PL-118.1 4627322 to 89% coli] gb|AAC73523.l| (AE000148) 1-deoxyxylulose

4629187 5-phosphate synthase,- flavoprotein

[Ξscherichia coli K12] gb|AAC46162.l|

(AF035440) D-1-deoxyxylulose 5-phosphate synthase [Ξscherichia coli] SΞQ ID n~241

Contig9 from gb|AAG54771.l|AE005221_8 (AE005221) SEQ ID n° 9920 PL-117.1 4629250 to 77% geranyltranstransferase (farnesyldiphosphate

4630167 synthase) [Escherichia coli θl57:H7] SEQ ID n~230

sp|P22938|EX7S_ΞCOLI EXODΞOXYRIBONUCLBASΞ VII

SMALL_SUBUNIT (BXONUCLEASE VII SMALL SUBUNIT) pir[ |JQ0664 exodeoxyribonuclease VII

(ΞC 3.1.11.6) small chain - Escherichia coli dbj |BAA005S8.1| (D00694) ORFl [Escherichia

Contig9 from

coli] gb|AAB40178.l] (U82664)

SEQ ID n° 9921 _PL-5225_. —4630172 to m 71% exσdeoxynbonuc ease small subunit [Escherichia 4630450 coli] gb]AAC73525.l| (AΞ000148) exonuclease

VII, small subunit [Escherichia coli K12] gb|AAG54772.l|AΞ00522l_9 (AE005221) exonuclease

VII, small subunit [Escherichia coli

0157.-H7] #N/A sp|P55913|THII_SALTY THIAMINE BIOSYNTHESIS

ContigS from PROTEIN THII pir | |T46944 thiamin biosynthesis

SΞQ ID n° 9922 PL-116.1 4630650 to 903 protein thil [validated] - Salmonella

46320S8 typhimurium gb|AAB63031.1 | (U94901) Thil

[Salmonella typhimurium] SEQ ID n~219 pir] |H64771 hydroxymethylpyrimidine kinase (ΞC

2.7.1.49) - Ξscherichia coli gb| AAA82704.l|

(U34923) ThiJ [Escherichia coli] gb|AAB40180. l|

ContigS from (U82664) 4-methyl-5 (b-hydroxyethyl) -thiazole

SΞQ ID n° 9923 PL-5228.1 4631941 to m 353 monophosphate biosynthesis protein

4632318 [Escherichia coli] gb |AAC73527.1 | (AΞ000148) 4- methyl-5 (beta-hydroxyethyl) -thiazole monophosphate synthesis [Escherichia coli K12] #N/A sp|P777 8|APBA_ECOLI 2-DEHYDROPANTOATΞ 2-

RΞDUCTASΞ (KΞTOPANTOATΞ REDUCTASΞ) (KPA

REDUCTASE) pir| |A64772 ketopantoate reductase -

Contig9 from

Escherichia coli gb |AAB40181.1 | (U82664)

SEQ ID n° 9924 PL-115.1 4632315 to 63^! similar to S. typhimurium apbA [Escherichia

4633187 coli] gb|AAC73528.l| (AE000148) involved in thiamin biosynthesis, alternative pyrimidine biosynthesis [Escherichia coli K12] SEQ ID n~208

sp|P77482|YAJQ_ECOLI PROTEIN YAJQ pir||B64772 yajQ protein - Escherichia coli gb] AAB40182.l|

ContigS from (U82664) similar to H. influenzae HI1034

SEQ ID n° 9S25 PL-3370.1 4633323 to 763 [Escherichia coïï] gb | AC7352 .11 (AE000149)

4633814 orf, hypothetical protein [Escherichia coli K12]

gb|AAG54776.l|AE005222_l (AE005222) orf, hypothetical proteιrr^"[Eschefichia coli 0157 :H7] SEQ ID n~2604 sp|P77726|YAJR_ECOLI HYPOTHETICAL 49.0 KD

PROTEIN IN ABPA-CYOE INTERGΞNIC RΞGION

Contig9 from pir| |C64772 probable transport protein yajR - SEQ ID n° 9326 PL-114.1 4633938^" tσ m 793 Ξscherichia ^"Coli— gb| AAB40183.11 (U82664)

4635317 hypothetical protein [Bscherichia coli] gb|AAC73530.l| (AΞO00149) putative transport protein [Escherichia coli K12] SEQ ID n~297

Contig9 from gb| AAB40184.l| (U82664) cytochrome o ubiquinol

SEQ ID n° 9927 PL-113.1 4635472 to 87% oxidase C subunit [Escherichia coli]

4636356 SΞQ ID n~286

Contig9 from gb| AB40185.l| (U82664) cytochrome o ubiquinol

SEQ ID n° 9928 PL-5230.1 4636369 to m 79% oxidase C subunit [Ξscherichia coli]

4636701 #N/A

Contig9 from gb|AAG54780.l|AΞ005222_5 (AE005222) cytochrome o

SEQ ID n° 9929 PL-112.1 4636701 to 84% ubiquinol oxidase subunit III [Escherichia

4637315 coli 0157 :H7] SΞQ ID n~275

sp|P1840l|CYOB_ECOLI UBIQUINOL OXIDASE . POLYPEPTIDE I (CYTOCHROME O SUBUNIT 1) (OXIDASB BO(3) SUBUNIT 1) (CYTOCHROME O UBIQUINOL OXIDASE

SUBUNIT 1) (UBIQUINOL OXIDASE CHAIN

A) pir] [B42226 bo-type ubiquinol oxidase (EC

1.10.3.-) chain I - Escherichia coli pdb|lFFT|A

Chain A, The Structure Of ubiquinol Oxidase From

Escherichia Coli pdb|lFFT|F Chain F, The

Contig9 from

Structure Of Ubiquinol Oxidase From Ξscherichia

SEQ ID n° 9930 PL-110.1 4637305 to m 903

Coli gb|AAA23632.l| (J054S2) cytochrome o

4639296 ubiquinol oxidase B subunit I ^"[Ξscherichia coli] gb|AAB40187.l| (U82664) cytochrome o ubiquinol oxidase [Escherichia coli] gb|AAC73534.l] (AΞ000149) cytochrome o ubiquinol oxidase subunit I [Ξscherichia coli

K12] gb|AAG54781.l|AΞ005222_6 (AΞ005222) cytochrome o ubiquinol oxidase subunit I

[Escherichia coli 0157 :H7] SEQ ID n~253 sp|P18400|CYOA_ECOLI UBIQUINOL OXIDASΞ

POLYPΞPTIDE II PRECURSOR (CYTOCHROME O SUBUNIT

2) (OXIDASB BO(3) SUBUNIT 2)

(CYTOCHROME O UBIQUINOL OXIDASE

SUBUNIT 2) (UBIQUINOL OXIDASE CHAIN B) pir| |A42226 bo-type ubiquinol oxidase (ΞC

1.10.3.-) chain II precursor -

Escherichia coli pdb|lFFT|B Chain B, The

Contig9 from

Structure Of Ubiquinol Oxidase From Escherichia

SEQ ID n° 9931 PL-109.1 4639301 to m 783

Coli pdb|lFFT|G Chain G, The Structure Of

4640236

Ubiquinol Oxidase From Escherichia Coli gb|AAA23631.l| (J05492) cytochrome o ubiquinol oxidase subunit II [Escherichia coli] gb| AAB40188.1] (U82664) cytochrome o ubiquinol oxidase subunit II [Escherichia coli] gb|AAC73535.l| (AE000149) cytochrome o ubiquinol oxidase subunit II [Ξscherichia coli

K12] SΞQ ID n~241

sp|P45564|YFΞN_ECOLI HYPOTHETICAL 29.2 KDA

PROTEIN IN -XAPA-LIG INTERGENIC REGION

(ORF254)_— ir_|_]-.G≤5.0_l_4. hypothetical 29.2K protein - b2408 - Ξscherichia coli (strain K-12)

Contig9 from emb|CAA52046.l| (X73828) or£254 [Ξscherichia

SΞQ ID n° 9932 PL-108.1 4640586 to m 71%

coli] gb|AAC75461.l] (AΞ000328) putative sugar 4-6-4-13-4-7- hydrolase [Escherichia coli K12] dbj |BAA16279.l| (D90870) similar to [SwissProt

Accession Number P45564] [Escherichia COli] SEQ ID n~231 sp|P3~667θ|AMPG_ECOLI AMPG PROTΞIN pir|]S37391 signal transducer ampG - Ξscherichia coli gb|AAB28884.l| (S67816) AmpG [Escherichia coli] gb] AAB40189.l| (U82664) beta-lactamase induction

Contig9 from signal transducer AmpG [Escherichia

SEQ ID n° 9933 PL-107.1 4641598 to m 773 coli] gb|AAC73536.l| (AE000149) régulâtes beta-

4643076 lactamase synthesis [Escherichia coli K12] gb|AAG54783.l|AE005222_8 (AE005222) régulâtes beta-lactamase synthesis [Escherichia coli 0157.-H7] SEQ ID n~220

Contig9 from gb[AAG54784.l|AΞ005222_9 (AE005222) yajG gène

SEQ ID n° 9934 PL-106.1 4643130 to m 733 product [Escherichia coli 0157 :H7]

4643708 SEQ ID n~20 S

Contig from

SEQ ID n° 9335 PL-5232.1 4643952 to 683 sp|P15298|B0LA_EC0LI BOLA PROTBIN

4644266 #N/A sp|P22 57|TIG_ΞC0LI TRIGGΞR FACTOR (TF) pir| |D64773 trigger factor [validated] -

Escherichia coli gb] AAB40192.l| (U82664) trigger factor [Ξscherichia coli]

Contig9 from gb|AAC73539.l| (AΞ000150) trigger factor; a

SEQ ID n° 3336 PL-104.1 4644645 to 89% molecular chaperone involved in cell

4645949 division [Ξscherichia coli K12] gb|AAG54786.l|AΞ005223_l (AΞ005223) trigger factor; a molecular chaperone involved in cell division [Escherichia coli 0157 :H7] SEQ ID n~87

sp|Q60107|CLPP_YERΞN ATP-DΞPENDENT CLP PROTEASE

Contig9 from PROTΞOLYTIC SUBUNIT (ΞNDOPΞPTIDASΞ CLP)

SEQ ID n° 3937 PL-103.1 4646223 to 94% gb|AAC45782.l| (U55059-)—G-l-pP—[Yersinia

4646846 enterocolitica] SEQ ID n~76

Contig9 from sp | 033873 |CLPX_YERΞN ATP-DΞPENDENT CLP PROTEASΞ

SEQ ID n? 9938 PL-102.1 4646983 to . -9.5_3 ATP-BINDING SUBUNIT

4648254 (U66330) Clp [Yersinia enterocolitica] SΞQ ID n~65

Contig9 from gbJAAB40195.l| (U82664) ATP-dependent protease

SEQ ID n° 9939 PL-101.1 4648463 to 95% LA [Escherichia coli]

4650817 SEQ ID n~S5 sp|P0234l|DBHB_ECOLI DNA-BINDING PROTEIN HU-BETA

(NSI) (HU-1) pir| |DNECS1 DNA-binding protein HU

1 - Ξscherichia coli emb|CAA34539.1 | (X16540)

HU-1 protein (AA 1-90) [Escherichia coli]

Contig9 from gb|AAB40l96.l| (U82664) DNA-binding protein NSI SEQ ID n° S940 PL-5235.1 4651046 to 803 [Escherichia coli] gb|AAC73543. l| (AE000150)

4651321 DNA-binding protein HU-beta, NSI (HU-1)

[Escherichia coli K12] gb|AAG54790.l|AE005223_5 (AE005223) DNA-binding protein HU-beta, NSI (HU-1) [Escherichia coli 0157 :H7] #N/A sp|P7724l|PPID_ECOLI PΞPTIDYL-PROLYL CIS-TRANS

ISOMERASE D (PPIASE D) (ROTAMASE D) pir| ]A64774 ybaU protein - Escherichia coli dbj |BAA11645.l|

Contig9 from

(D82943) YbaU [Escherichia coli] gb j AAB40197. l|

SEQ ID n° 9941 PL-100.1 4651615 to 67%

(U82664) similar to H. influenzae HI1004

4653486

[Escherichia coli] gb|AAC73544.1 | (AEO00150) putative protease maturation protein

[Ξscherichia coli K12] SEQ ID n~44

Contig9 from gb|AAG54792.l[AΞ005223_7 (AE005223) orf, SEQ ID n° 9942 PL-3371.1 4653637 to 41% hypothetical protein [Ξscherichia coli 0157 :H7]

4654011 SΞQ ID n~∑ 605

sp|P77712|YBAW_EC0LI HYPOTHETICAL 15.1 KD

PROTEIN IN HUPB-COF INTERGENIC REGION

. ContigS from -pir-|-]-C6-4774_ ybaW protein - Escherichia—col-i-

SEQ ID n° 9943 PL-5236.1 4654165 to p 663 dbj |BAA11647.l| (D82943) YbaW [Ξscherichia coli]

4654572 gb[AAB40199.l| (U82664) hypothetical protein

[Bscherichia coli] gb| AAC73546.11 (AE000L5.0) orf, hypothetical protein [Escherichia coli K12] #N/A

Contig9 from gb|AAG54794.l|AΞ005223_9 (AE005223) orf, SEQ ID n° 9944 PL-99.1 4654601 to m 833 hypothetical protein [Ξscherichia coli 0157 :H7]

4655299 SEQ ID n~S845 pir| |G82247 cysteine synthase/cystathionine beta- synthase family protein VC1061

Contig9 from [imported] - Vibrio cholerae (group 01 strain SEQ ID n° 9945 PL-98.1 4655332 to m 82% N16961) gb|AAF94220.l| (AE004187) cysteine

4656384 synthase/cystathionine beta-synthase family protein [Vibrio cholerae] SEQ ID n~3834 pir| |G64774 regulatory protein b0447 - Escherichia coli gb | AAB40203.1 ] (U82664)

Contig9 from similar to Z. obilis glutamate uptake SEQ ID n° 9946 PL-3372.1 4656512 to p 84% regulatory protein [Escherichia coli]

4656973 gb|AAC73550.l| (AE000151) putative LRP-like transcriptional regulator [Escherichia coli K12] SEQ ID n~2606 Sp|P77265|MDLA_ECOLI MULTIDRUG RESISTANCE-LIKΞ ATP-BINDING PROTEIN MDLA pir| |H64774 ABC-type transport protein mdlA - Escherichia coli

ContigS from gb|AAB40204. l| (U82664) multidrug resistance-

SEQ ID n^D 9947 PL-97.1 4657060 to p 813 like ATP-binding protein Mdl

4658829

[Escherichia coli] gb | AAC73551.l| (AE0001Ξ1)

ATP-binding component of a transport system

[Escherichia coli K12] SEQ ID n~3823

ContigS from gb]AAB40205.l| (U82664) multidrug résistance-

SEQ ID n° 9948 PL-96.1 4658822 to 81% like ATP-binding protein Mdl

4660606 [Escherichia coli] SEQ ID n~3812

Contig9 from gb|AAB40206.l| (U82664) glutamine synthetase SEQ ID n° 9949 PL-5238.1 4660787 to - —p 83% activity régulation protein

__—4_6_6_1125 [Escheή-chia—coli] - #N/A- sp|P37905|AMTB_ECOLI PROBABLE AMMONIUM

TRANSPORTER pir[|C64775 ammonium transport

protein amtB - Escjherichia coli gb] AAD14837.1]

(U40429) AmtB [Ξscherichia coli] gb |AAB40207.l|

ContigS from

(U82664) putative ammonium transporter

SEQ ID n° 9950 PL- 95.1 4661112 to 723

[Escherichia coli] gb | AAC73554.1 | (AΞ000151)

4662431 probable ammonium transporter [Escherichia coli

K12] gb|AAG54801.l|AE005224_6 (AE005224) probable ammonium transporter [Ξscherichia coli

0157 :H7] SEQ ID n~3801 sp|P2391l|TΞSB_ΞC0LI ACYL-COA THIOΞSTΞRASE II

(TEII) pir] |D64775 acyl-CoA thiolesterase (ΞC

3.1.2.-) II - Ξscherichia coli gb|AAA24665. l|

Contig9 from (M63308) thioesterase II [Ξscherichia coli] SEQ ID n° 9951 PL- 94.1 4662504 to m 793 gb|AAB40208.l| (U82664) acyl-coA thioesterase II

4663367 [Escherichia coli] gb|AAC73555.1 ( (AE000151) acyl -CoA thioesterase II [Escherichia coli K12] gb|AAG54802.l|AE005224_7 (AΞ005224) acyl-CoA thioesterase II [Escherichia coli 0157 :H7] SEQ ID n~3790

Contig9 from gb|AAG54803.l]AE005224_8 (AE005224) SEQ ID n° 9952 PL-3373.1 4663618 to 643 glycoprotein/polysaccharide metabolism

4664064 [Escherichia coli 0157 :H7] SEQ ID n~2607 sp|P2772θ|YMOA_YΞREN MODULATING PROTEIN YMOA

Contig9 from (HISTONE-LIKE PROTEIN) pir| |S15291 modulating SEQ ID n° 9953 PL-5239.1 4664376 to m 903 protein ymoA - Yersinia enterocolitica

4664579 emb|CAA41091.l| (X58058) ymoA [Yersinia enterocolitica] #N/A

sp|P31224|ACRB_ECOLI ACRIFLAVIN RESISTANCE

PROTEIN B pir| |B36938 acriflavin résistance

—protein acrB - Escherichia

ContigS from (M34248) acriflavine résistance protein

SEQ ID n° 9954 PL- 93.1 4665634 to m 893 [Ξscherichia coli] gb|AAA67135. l| (U00734) 114

4668783 kDa protein [Escherichia coli] _gb-|-AAB4-02-16 -11 .

(U82664) probable transmembrane protem AcrE

[Escherichia coli] gb|AAC73564.l| (AE000152) acridine efflux pump [Escherichia coli K12] SEQ ID n~3779 sp | P31 23 | ACRA_ΞCOLI ACRIFLAVIN RESISTANCE

PROTEIN A PRECURSOR pir | |A36S38 acriflavin résistance protein acrA precursor - Ξscherichia coli gb|AAA23410.l| (M94248) acriflavine résistance protein [Ξscherichia coli]

Contig9 from gb|AAA67l3 .l| (U00734) 42 kDa protein SEQ ID n° SS55 PL-32.1 4668811 to 8 =

[Ξscherichia coli] gb] AAB40217.1 ] (U82664)

4670004 lipoprotein AcrA precursor [Bscherichia coli] gb|AAC73565.l| (AΞ000152) acridine efflux pump

[Escherichia coli K12] gb| AAG54812.1 | AΞ005225_6

(AΞO 05225) acridine efflux pump [Ξscherichia coli 0157:H7] SΞQ ID n~3769

ContigS from gb|AAG54813.l|AΞ005225_7 (AE005225) acrAB operon SEQ ID n° SS56 PL-31.1 4670134 to 703 repressor [Ξscherichia coli 0157 :H7]

4670775 SEQ ID n~3758 pir| |B75270 ABC transporter, ATP-binding protein

ContigS from - Deinococcus radiodurans (strain RI) SEQ ID n° 3357 PL-30.1 467118S to 77% gb|AAF12012.l|AΞ002076_4 (AΞ002076) ABC

4671863 transporter, ATP-binding protein [Deinococcus radiodurans] SEQ ID n~3747 pir] |A75270 conserved hypothetical protein -

Contig9 from

Deinococcus radiodurans (strain RI) SΞQ ID n° 9958 PL-89.1 4671860 to p 63^: gb|AAF12011.l|AΞ002076_3 (AΞ002076) conserved

4672489 hypothetical protein [Deinococcus radiodurans] SEQ ID n~3735

pir| ]C75270 probable biotin synthase -

Contig9 from

Deinococcus radiodurans (strain Ri) SΞQ ID n° 9959 PL-3374 . 1 4672530 to 71% gb_|.AAF12.013_._l-|_AE002076_5 (AE002076) biotin

4^"6v3078 ^""" synthase, putative [Deinococcus radiodurans] SEQ ID n~2608

Contig9 from

gb|AAF17282.l| (AF204805) unknown [Nostoc sp. SEQ ID n° 9960 PL-88.1 4673197 to m 54% --= GSV224]

4673961 SEQ ID n~3724 ref |NP_070641. l| hypothetical protein

[Archaeoglobus fulgidus] pir| |E69476

Contig9 from hypothetical protein AF1814 - Archaeoglobus SEQ ID n° 9961 P -33-75.1 4674084 to 363 fulgidus gb] AAB89439. l| (AΞ000977) A. fulgidus

4674521 predicted coding région AF1814

[Archaeoglobus fulgidus] SEQ ID n-2609

Contig9 from gb|AAG54815.l|AΞ005225_9 (AE005225) Z0583 gène SΞQ ID n° 9962 PL-5243.1 4674650 to m 463 product [Escherichia coli 0157 :H7]

4674817 #N/A sp|P23862 |PRIC_ECOLI PRIMOSOMAL REPLICATION PROTEIN N" pir| | JQ1149 primosomal réplication factor N prie [validated] - Escherichia coli db (BAA03055. l| (D13958) primosomal réplication

Contig9 from protein n' (gtg start codon) SEQ ID n° 9963 PL-3376.1 4674840 to m 52%

[Ξscherichia coli] gb| AAB40221.1 | (U82664)

4675382 primosomal réplication protein n [Escherichia coli] gb|AAC73569.l| (AΞ000153) primosomal réplication protein N' ' [Ξscherichia coli

K12] SΞQ ID n~2610

Contig9 from gb|AAB40223.1j (U82664) adenine

SEQ ID n° 9964 PL-3377.1 4675526 to 833 phosphoribosyltransferase [Bscherichia coli]

4676077 SΞQ ID n~26U

Contig9 from gb |AAG54819. l | AE005226_2 (AE005226) DNA

SΞQ ID n° 9965 PL-87.1 4676174 to 76% polymerase III , tau and gamma subunits ; DNA

4678150 elongation factor III [Ξscherichia coli 0157 : H7] SΞQ ID n~3714

sp|P17577|YBAB_ECOLI HYPOTHBTICAL 12.0 KDA

- C

SΞQ ID n° 9966 PL-5244.1

hypothetical protein [Bscherichia coli 0157 :H7] #N/A sp]P12727]RECR_EC0LI RECOMBINATION PROTEIN RECR pir| |BVECRR recombination protein recR - Escherichia coli emb cAA33768.1 | (X15761) recR product (AA 1-201) [Escherichia coli]

Contig3 from gb|AAB40226.l| (U82664) recR [Ξscherichia coli]

SEQ ID n° 9967 PL-86.1 4678536 to 903 gb|AAC73574.l| (AΞ000153) recombination and

4673141 repair [Ξscherichia coli K12] gb|AAG54821.l|AE005226_4 (AE005226) recombination and repair [Escherichia coli

0157 :H7] SΞQ ID n~3703 sp|P44523|HXCl_HAΞIN HΞME-HEMOPE IN UTILIZATION

ContigS from PROTEIN C PRECURSOR pir| |B64049 outer membrane

SEQ ID n° 9968 PL-85.1 4679538 to 433 protein hxuC homolog - Haemophilus influenzae

4681610 (strain Rd KW20) gb|AAC21789. l| (U32696) he in receptor (hemR) [Haemophilus influenzae Rd] SΞQ ID n~S692

Sp|P10413 |HTPG_ECOLI HEAT SHOCK PROTEIN HTPG

(HIGH TEMPERATURE PROTEIN G) (HEAT SHOCK

PROTΞIN C62.5) pir| |HHΞC62 heat shock protein

Contig9 from C62.5 - Ξscherichia coli gb| AAA23460.1 |

SΞQ ID n° 3969 PL-84.1 4682135 to 91% (M38777) htpG ORF [Ξscherichia coli]

4684027 gb|AAB40227.l| (U82664) heat shock protein HtpG

[Escherichia coli] gb| AAC73575.1 | (AΞ000153) chaperone Hsp90, heat shock protein C 62.5

[Ξscherichia coli K12] SEQ ID n~3681

Contιg9 from gb|AAB40228.l| (U82664) adenylate kinase

SEQ ID n° 3970 PL-83.1 4684210 to [Ξscherichia coli]

4684854 SEQ ID n~S670

sp | 43 13 | HEMZ_YERΞN FERROCHELATASE ( PROTOHEME

Contig9 from FERRO-LYASΞ) (HEME SYNTHETASE) pir||S70735 SEQ ID n° 9971 PL-82.1 4685031 to 76% ferrochelatase (ΞC 4.99.1.1) - Yersinia

4686008 enterocolitica eemmbb||CCAAAA8877669977..lll| (Z47767) ferrochelatase [Yersinia enterocolitica]

Contig9 from emb|CAB63286.l| (AJ251713) O-antigen chain

SEQ ID n° 9972 PL-81.1 4686192 to 653 length déterminant-like protein

4687295 [Yersinia pestis] SEQ ID n~3649 sp|P22937|lNGK_EC0LI INOSINE-GUANOSINE KINASE pir|]jQ0812 inosine kinase (EC 2.7.1.73) -

Escherichia coli dbj |BAA00690. l| (DÔ0798)^"

Contig9 from inosine-guanosine kinase [Escherichia coli] SΞQ ID n° 9973 PL-80.1 46873S4 to P 893 gb|AAB40231.l| (U82664) inosine kinase

4688704 [Ξscherichia coli] gb |AAC73579.l| (AE000154) inosine-guanosine kinase [Ξscherichia coli K12] gb|AAG54826.l|AΞ005226_9 (AΞ005226) inosine- guanosine kinase [Ξscherichia coli 0157 :H7] SEQ ID n~3638

ContigS from pir||C55543 cmaU protein - Pseudomonas syringae SEQ ID n° 9374 PL-73.1 4689854 to 42% pv. syringae gb| AAC46034.1 [ (U14657) CmaU

4690465 [Pseudomonas syringae] SEQ ID n~3626 Contig9 from SΞQ ID n° 9975 PL-5247.1 4690663 to m No Hits found

4690881 #N/A

Contig9 from gb|AAG54827.l|AE005227_l (AE005227) putative

SEQ ID n° 9976 PL-78.1 46S0878 to m 833 transport protein [Escherichia coli 0157 :H7]

4692584 SΞQ ID n~3615

Contig9 from gb|AAG54828.l|AE005227_2 (AΞ005227) fosmidomycin

SEQ ID n° 9977 PL-77.1 4692826 to m 833 résistance protein [Ξscherichia coli

4694043 0157 :H7] SΞQ ID n~3604 pir||JC7221 UDP (uridine 5' -diphosphate) -sugar

Contig9 from hydrolase (ΞC 3.-.-.-) - Enterobacter SEQ ID n° 9378 PL-76.1 4634434 to p 803 aerogenes gb |AAF12718. l| AF068226_1 (AF068226)

4636092 UDP-sugar hydrolase precursor [Enterobacter aerogenes] SEQ ID n~3594

sp|P37175|YBAK_ECOLI PROTΞIN YBAK pir||H64778

ContigS from ybaK protein - Ξscherichia coli gb|AAB40235.1 |

SEQ ID n° 9S79 PL-3378.1 4-6a6154— o 693 (U82664)—simi-1-ar— o-H. influenzae HI1434

4696630 [Escherichia coli] gb| AAC73583.l| (AE000154) orf, hypothetical protem [Escherichia coli K12] SEQ ID n~2612

βp | P77301-|-YBAP—ECOLI-HYPOTHΞTICAL 29.9 KD —

PROTΞIN IN USHA-TΞSA INTERGENIC REGION

ContigS from pir| |A64779 ybaP protein - Escheπchia coli SEQ ID n° 9980 PL- 75.1 4696831 to 633 gb|AAB40236.l| (U82664) hypothetical protein

4697643

[Bscherichia coli] gb| AAC73584.l| (AΞ000154) putative ligase [Ξscherichia coli K12] SΞQ ID n~3583

Contig9 from SEQ ID n° 9981 PL-5249.1 4697925 to No Hits found

4698242 #N/A Contig9 from gb|AAG54833.l|AΞ005227_7 (AΞ005227) putative SEQ ID n° 9982 PL-74.1 4698369 to 77% ATPase_. [Ξscherichia coli 0157 :H7]

4701104 SΞQ ID^"n~3572 sp]P77565|YBBI_BCOLI HYPOTHETICAL

TRANSCRIPTIONAL REGULATOR IN USHA-TESA

INTERGΞNIC REGION pir| |F64779

Contig9 from probable transcription regulator ybbl - SEQ ID n° 9983 PL-5250.1 4701246 to 77% Escherichia coli gb|AAB40241.l| (U82664)

4701647 similar to H. influenzae HI0293 [Escherichia coli] gb|AAC73589.l| (AΞ000155) putative transcriptional regulator [Ξscherichia coli

K12] #N/A sp|P75709|YBBJ_ECOLI HYPOTHETICAL 16.8 KD

Contig9 from PROTEIN IN USHA-TΞSA INTΞRGΞNIC REGION SEQ ID n° 9984 PL-3379.1 4701641 to m 61% pir| |G64779 probable membrane protein ybbJ -

4702096 Escherichia coli gb] AAC73590. l| (AE000155) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~2613

sp|P77367|YBBK_ECOLI HYPOTHBTICAL 33.7 KD

PROTEIN IN USHA-TESA INTERGENIC RΞGION pir| |H64773 probable membrane— rotein-ybbK -

Contig9 from Escherichia coli gb | AAB40243.1 | (U82664)

SBQ ID n° 9985 PL-73.1 4702099 to 883 similar to M. tuberculosis MTCY277.0S

4703019 [Escherichia coli] gb |AAC7_3_5_3_1_._1_| (AE.000155) putative protease [Escherichia coli K12] gb|AAG54846.l|AE005230_6 (AE005230) putative protease [Escherichia coli 0157 :H7] SEQ ID n~3562

Contig9 from gb|AAG54849.l| AEO05230 9 (AΞ005230) putative

SEQ ID n° 9986 PL-72.1 4703044 to m 77% thioredoxin-like protein [Escherichia coli

4703901 0157:H7] SEQ ID n~3552

Contig9 from gb|AAG54850.l|AE005230_10 (AE005230) putative

SEQ ID n° 9987 PL-71.1 4703970 to m 78% oxidoreductase [Escherichia coli 0157 :H7]

4704755 SEQ ID n~3541

Contig9 from gb|AAB40248.l| (U82664) acyl-coA thioesterase I

SEQ ID n° 9988 PL-70.1 4704806 to m 65% precursor [Escherichia coli]

4705441 SEQ ID n~3530 sp|P31219|YBBA_EC0LI HYPOTHΞTICAL ABC

TRANSPORTER ATP-BINDING PROTEIN YBBA pir||F64780 probable ABC-type transport protein ybbA - Ξscherichia coli gb|AAB40249.l| (U82664)

Contig9 from hypothetical abc transporter [Escherichia coli]

SEQ ID n° 9989 PL-69.1 4705403 to 853 gb(AAC73597.l] (AE000155) putative ATP-binding

4706035 component of a transport System

[Ξscherichia coli K12] gb|AAG54852.l|AΞ005230_12 (AΞ005230) putative

ATP-binding component of a transport system

[Escherichia coli 0157 :H7] SEQ ID n-3519 sp|P77504|YBBP_ECOLI HYPOTHBTICAL 89.3 KD

PROTΞIN IN TΞSA-RHSD INTERGENIC RΞGION

ContigS from pir] |G64780 probable membrane protein ybbp -

SEQ ID n° 9990 PL-68.1 4706032 to 783 Ξscherichia coli gb| AAB40250.1 | (U82664)

4708524 hypothetical protein [Bscherichia coli] gb|AAC73598.l| (AE000155) putative oxidoreductase [Escheπchia coli K12] SEQ ID n~3508

pir| |B64843 hypothetical protein bl012 -

SEQ ID n° 9391 PL

—._— —.r gion. [Escherichia coli] .SBQ_ID_n~3498 sp|P37482| ΥCB_BACSU HYPOTHETICAL 43.2 KD

PROTEIN IN DNAC-RPLI INTERGENIC RΞGION

Contig9 from pir||S65973 transport protein homolog yycB - SΞQ ID n° 9992 _ SL- 66 . 1 4709869 to 383 Bacillus subtilis dbj JBAA05179.1] (D26185

4711143 unknown [Bacillus subtilis] emb|CABi6085. l |

(Z99124) similar to ABC transporter (permease)

[Bacillus subtilis] SΞQ ID n~3488 pir||C83625 hypothetical protein PA0165

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 9993 PL-65.1 4711199 to 33% (strain PAOl) gb|AAG03555. l|AE004454_7

4712113 (AEO04454) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~3477 sp|P45273 |RISA_HAEIN RIBOFLAVIN SYNTHASΞ ALPHA

CHAIN pir| |Ξ64132 riboflavin synthase (ΞC

Contig9 from

2.5.1.9) alpha cham - Haemophilus SEQ ID n° 9994 PL-64.1 4713134 to 53% influenzae gb| AAC23257.1 | (U32834) riboflavin

4713799 synthase, alpha chain (ribΞ) [Haemophilus influenzae Rd] SΞQ ID n~3466

Contig9 from gb[AAF81206.l|AF247502_l (AF247502) Ytl2 SEQ ID n° 9995 PL- 63.1 4714501 to 70% [Salmonella dublin]

4715463 SΞQ ID n~3455 ref |NP_047874.1 | putative transposase [Yersinia pestis] pir| |T14989 probable transposase -

Contig9 from

Yersinia pestis plasmid pMTl gb| AC82732.1 | SEQ ID n° 9996 PL-5253.1 4715614 to 493

(AF074611) putative transposase [Yersinia

4715817 pestis] emb|CABS5253. ι| (AL117211) hypothetical protein YPMT1.71 [Yersinia pestis] #N/A

Contig9 from SEQ ID n° 9997 PL-6968.1 4716279 to No Hits found

4716374 #N/A

sp | PO9029 | PURK_ΞCOLI PHOSPHORIBOSYLAMINOIMIDAZOLE-CARBOXYLASΞ ATPASE

SUBUNIT (AIR CARBOXYLASE) . (AIRC) pir| |DCΞCPK phosphoribosylaminoimidazole carboxylase (ΞC 4.1.1.21) carbon

dioxide-fixation chain - Ξscherichia coli

ContigS from gb |AAA24450.1 f (MÏS6577 5^~7 phosphoribosyl-5-

SΞQ ID n° 9998 PL-62.1 4716730 to m 76% amino- -imidazole carboxylase II

4717827 (purK, EC 4.1.1.21) [Ξscherichia coli] gb|AAB40275.l| (U82664) 5 ' -phosphoribosyl-5- amino-4-imidazole carboxylase II

[Ξscherichia coli] gb|AAC73624.1 | (AE000158) phosphoribosylaminoimidazole carboxylase = AIR carboxylase, CO(2)-fixing subunit [Escherichia coli K12] SΞQ ID n~3444 sp | PO90 8 | PUR6_ECOLI

PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE

CATALYTIC SUBUNIT (AIR CARBOXYLASE)

(AIRC) pir| | DΞΞCPΞ phosphoribosylaminoimidazole carboxylase (ΞC 4.1.1.21) catalytic chain - Ξscherichia coli emb| CAA31420.l|

(X12982) purE gène product (catalytic subunit)

(AA 1- 16S) [Escherichia coli] gb|AAA24449.l| (M19657) 5 ' -phosphoribosyl-5-

Contig9 from amino-4-imidazole carboxylase I (purE, SΞQ ID n° 9999 PL-3380.1 4717824 to 82%

ΞC 4.1.1.21) [Escherichia coli] gb] AB40276.l|

4718354

(U82664) phosphoribosylaminoimidazole carboxylase [Escherichia coli] gb|AAC73625.l| (AΞ000158) phosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit [Ξscherichia coli

K12] gb|AAG54880.l|AΞ005233_6 (AΞ005233) phosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit [Ξscherichia coli

0157 : H7] SΞQ ID n~2615

Contig9 from gb|AAG54881.l|AE005233__7 (AE005233) orf,

SEQ ID n° 10000 PL-61.1 4718502 to m 68% hypothetical protein [Escherichia coli 0157 :H7]

4719224 _SEQ ID n~S434

ContigS from gb|AAG54882.l|AΞ005233_8 (AΞ005233) peptidyl-

SEQ ID n° 10001 PL-3381.1 4719235 to m 77% prolyl cis-trans isomerase B (rotamase B)

4719729 [Escherichia coli 0157 :H7] SEQ ID n~2616

Contig9 from gb|AAB40278.l] (U82664) hypothetical protein

SEQ ID n° 10002 PL-5254.1 4719604 to 703 [Escherichia coli]

4719735 #N/A sp|P21888 |SYC_ECOLI CYSTEINYL-TRNA SYNTHΞTASΞ (CYSTEINE--TRNA LIGASE) (CYSRS) ^~pïr| |YYEC cysteine- -tRNA ligase (ΞC 6.1.1.16) -

Ξscherichia coli emb| CAA41983.l] (X59293)

Contig9 from cysteinyl-tRNA synthetase [Escherichia coli]

SΞQ ID n° 10003 PL-60.1 4719997 to 85% gb|AAA23658.l| (M59381) transfer RNA-Cys

4721382 synthetase [Ξscherichia coli] gb|AAB40279.l[

(U82664) cysteinyl-tRNA synthetase [Escherichia coli] gb|AAC73628.l| (AΞ000158) cysteine tRNA synthetase [Escherichia coli K12] prf | [1714234A

Cys-tRNA synthetase [Escherichia coli] SBQ ID n~3423

Contig9 from pir| |D42463 hypothetical protein Bcv' (pinB 5'

SΞQ ID n° 10004 PL-59.1 4721451 to 223 région) - Shigella boydii (fragment)

4723304 SΞQ ID n~3411

Contig9 from pir| |Ξ71694 hypothetical protein RP372 -

SΞQ ID n° 10005 PL-58.1 4723734 to m 583 Rickettsia prowazekii emb | CAA14831.1 |

4724651 (AJ235271) unknown [Rickettsia prowazekii] SΞQ ID n~3400

Contig9 from pir| (T36184 probable oxygenase - Streptomyces

SEQ ID n° 10006 PL-57.1 4724664 to 35% coelicolor emb|CAB38880. l| (AL035707) putative

4725668 oxygenase [Streptomyces coelicolor A3 (2)] SΞQ ID n~3390

sp|P76459|ATOA_ΞCOLI ACETATE COA-TRANSFERASE

BETA SUBUNIT (ACETYL-COA:ACΞTOACETATE COA

TRANSFERASELBΞTA—SUBUNIT) .pir| |D64992 butyrate-- acetoacetate CoA-transferase (EC 2.8.3.9) large

Contig9 from chain homolog atoA [similarity] -

SΞQ ID n° 10007 PL-56.1 4726512 to 72? Escherichia coli (strain K-12)

4727171 dbj |BAA16018.l| (D90851) Acetyl-CoA: acetoacetyl-

CoA transferase b subunit (EC 2.8.3.-

). [Escherichia coli] gb| AAC75282. l| (AE000311) acetyl-CoA:acetoacetyl-CoA transferase beta subunit [Escherichia coli K12] SEQ ID n~33 79 sp|P76458|ATOD_ΞCOLI ACΞTATE COA-TRANSFΞRASΞ

ALPHA SUBUNIT (ACΞTYL-COA: CΞTOACETATΞ COA

TRANSFERASE ALPHA SUBUNIT) pir] |C64992 atoD

Contig9 from protein - Escherichia coli (strain K-12)

SΞQ ID n° 10008 PL-55.1 4727174 to m 823 dbj |BAAl6017.l| (D90851) Acetyl-CoA: acetoacetyl- - - 4727833 CoA transferase a subunit (EC 2.8.3.-

). [Escherichia coli] gb| AAC75281.1 | (AΞ000311) acetyl-CoA:acetoacetyl-CoA transferase alpha subunit [Escherichia coli K12] SΞQ ID n~3368 sp|Q06065 |ATOC_ECOLI ACΞTOACETATE METABOLISM

RBGULATORY PROTΞIN ATOC (ORNITHINΞ/ARGININΞ

DΞCARBOXYLASB INHIBITOR) (ORNITHINB

DECARBOXYLASE ANTIZYME) pir| ]B64992 acetoacetate metabolism regulatory protein atoC -

Escherichia coli gb|AAA60332.l| (U17902)

Contig9 from

NtrC/NifA-like protein regulator [Escherichia

SEQ ID n° 10009 PL-5257.1 4727830 to m 66? coli] dbj |BAA160l6.l| (D90851) Acetoacetate

4728234 metabolism regulatory protein AtoC (Ornithine

/ Arginine decarboxylase inhibitor) (Ornithine decarboxylase antizyme) . [Escherichia coli] gb|AAC75280.l| (AE000311) response regulator of ato, ornithine decarboxylase antizyme

(sensor ATOS) [Ξscherichia coli K12] #N/A

Contig9 from

SΞQ ID.n° 10010 PL-54.1 4728459 to No Hits- found

4729538 SEQ ID n~3357.

Contig9 from pir||S46408 hypothetical protein - Aeromonas

SEQ ID n° 10011 PL-53.1 4730381 to 623 salmonicida gb | AAA72049.l| (L27156) [Aeromonas

4731478 salmonicida gène, complète cds . ] , gène product SEQ ID n~3346

Contig3 from

SΞQ ID n° 10012 PL-3382.1 4732125 to No Hits found

4732574 SEQ ID n~2617

ContigS from

^"SΞQ ID n° 10013 PL-52.1 4733044 to m No Hits found

4734072 SEQ ID n~3335

Contig9 from

SΞQ ID n° 10014 PL-525S.1 4735646 to No Hits found

4736083 #N/A

Contig9 from

SΞQ ID n° 10015 PL-51.1 4736961 to -m No Hits found

4737794 SEQ ID n~3324

Contig9 from

SEQ ID n° 10016 PL-5260.1 4738647 to No Hits found

4738829 #N/A

Contig9 from gb|AAB40924.l| (U82821) major cold shock protein

SEQ ID n° 10017 PL-5261.1 4739280 to 71% CSPA2 [Yersinia enterocolitica]

4739495 #N/A

Contig9 from ref |NP_052386.1 | YopT chaperone SycT [Yersinia

SΞQ ID n° 10018 PL-5262.1 4739724 to m 69% enterocolitica] gb|AAD16809.l| (AF102990) YopT

4740116 chaperone SycT [Yersinia enterocolitica] #N/A ref |NP_054620.l| unknown [Yersinia pestis] ref ]NP_04761S.l| Yop targeted effector [Yersinia pestis] pir| |T43601 yop targeted effector yopT •

Contig9 from Yersinia pestis plasmid pCDl gb [AAC62582.1 | SEQ ID n° 1001S PL-50.1 4740113 to 633 (AF053346) unknown [Yersinia pestis]

4741036 gb|AAC6S833.l| (AF074612) Yop targeted effector

[Yersinia pestis] emb|CAB54897.l| (AL117189) putative cytotoxic effector protein [Yersinia pestis] SEQ ID n~3313

Contig9 from gb |AAC37030. l | (M74011) putative [Yersinia SEQ ID n° 10020 PL-49.1 4741251 to m 79% 4741868 enterocolitica]

SEQ ID n~3301 pir| |D83431 type III export protein PscK PA1724

Contig9 from [imported] - Pseudomonas aeruginosa

SEQ ID n° 10021 PL-48.1 4741847 to m 45% (strain PAOl) gb] AAG05113.l] Ξ004598_12

4742473 (AΞ004598) type III export protein PscK [Pseudomonas aeruginosa] SEQ ID n~3290

Contig9 from gb(AAC44781.l| (U56077) PscJ [Pseudomonas SΞQ ID n° 10022 PL-47.1 4742473 to m 86% aeruginosa]

^" 4743210 SEQ ID n~3279 pir| |B83431 type III export protein Pscl PA1722

Contigs from [imported] - Pseudomonas aeruginosa SΞQ ID n° 10023 PL-5266.1 4743217 to m 70% (strain PAOl) gb j AG05111.1 | AE004538_10

4743555 (AE004598) type III export protein Pscl

[Pseudomonas aeruginosa] #N/A ref |NP__054587.11 Yop proteins translocation- protein H homolog [Yersinia pestis] ref |NP_047581.l| secreted protein [Yersinia pestis] sp|Q00923|YSCH_YERPS YOP PROTEINS

TRANSLOCATION PROTEIN H (LOW CALCIUM RESPONSE

LOCUS PROTEIN P) pir | |T43568

Contig9 from translocation protein H homolog - Yersinia SEQ ID n° 10024 PL-46.1 4743631 to m 383 pestis plasmid pCDl gb| AAA27649.l| (M83986)

4744197 IcrP [Yersinia pseudotuberculosis] gb|AAC62547.l] (AF053946) Yop proteins translocation protein H homolog [Yersinia pestis] gb|AAC69828.l| (AF074612) secreted protein [Yersinia pestis] emb| CAB54934.l|

(AL117189) putative type III secretion protein

[Yersinia pestis] SBQ ID n~3268

ref |NP_054588.l| Yop proteins translocation protein G homolog [Yersinia pestis] ref |NP_047582-.l|—type-IXl- secretion protein

[Yersinia pestis] pir| |T43569 translocation

Contig9 from protein G homolog - Yersinia pestis plasmid pCDl

SΞQ ID n° 10025 PL-5267.1 4744130 to m 58? gb | AAC6254S_..l_L_j;AF_0_5_3_946)_ Yop proteins

4744543 translocation protein G homolog [Yersinia pestis] gb|AAC69777.l| (AF074612) type III secretion protein [Yersinia pestis] emb[CAB54933_.l| (AL11718S) putative type III secretion protein [Yersinia pestis] #N/A pir||G83430 type III export protein PscF PA1719

[imported] - Pseudomonas aeruginosa

ContigS from

(strain PAOl) gb|AAC44777.1 | (U56077) PscF

SΞQ ID n° 10026 PL-5268.1 4744546 to m 60?

[Pseudomonas aeruginosa]

4744800 gb|AAG05108.l|AE004598_7 (AΞ004598) type III export protein PscF [Pseudomonas aeruginosa] #N/A ref |NP_054530.l| Yop proteins translocation protein E homolog [Yersinia pestis] ref |NP_047584.l| type III secretion protein

[Yersinia pestis] pir| |T43571 type III

ContigS from secretion protein yscE - Yersinia pestis plasmid SΞQ ID n° 10027 PL-5263.1 4744784 to m 483 pCDl gb|AAC62550.l| (AF053346) Yop proteins

4745002 translocation protein E homolog [Yersinia pestis] gb|AAC69779.l| (AF074612) type III secretion protein [Yersinia pestis] emb|CAB54931.l| (AL117183) putative type III secretion protein [Yersinia pestis] #N/A pir| |Ξ83430 type III export protein PscD PA1717

Contig9 from [imported] - Pseudomonas aeruginosa

SEQ ID n° 10028 PL-45.1 4745002 to m 653 (strain PAOl) gb| AAG05106.l| E0045S8_5 4746270 (AE0045S8) type III export protein PscD

[Pseudomonas aeruginosa] SEQ ID n~3257

ref |NP_052413.l| secretin YscC [Yersinia enterocolitica] sp|Q01244 | YSCC YΞRΞN YOP

__ PROTEINS TRANSLOCATION PROTEIN—C„PRE.C_URSQR.

ContigS from pir| |C40361 virC-region hypothetical protein

SEQ ID n° 10023 PL-44.1 4746267 to 73? yscC precursor - Yersinia

4748135 enterocolitica plasmid pYV gb|AAC37020.l|

(M74011) yscC gène product [Yersinia enterocolitica] gb|AAD16836.1 | (AF102SS0) secretin YscC [Yersinia enterocolitica] SBQ ID n~3246 pir| |C83430 type III export apparatus protein

PA1715 [imported] - Pseudomonas

ContigS from aeruginosa (strain PAOl) SBQ ID n° 10030 PL-3384.1 4748108 to m 483 gb|AAG05104.l|AΞ004538_3 (AE004598) type III

4748530 export apparatus protein [Pseudomonas aeruginosa] SΞQ ID n~2618 pir| |B83430 hypothetical protein PA1714

ContigS from [imported] - Pseudomonas aeruginosa SΞQ ID n° 10031 PL-43.1 4748545 to 53% (strain PAOl) gb | AAG05103.1 | AE004598_2

4749378 (AE004598) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~3237

Sp|P26SS3|EXSA_PSEAΞ EXOENZYME S SYNTHESIS

REGULATORY PROTEIN EXSA pir| |A83430

Contig9 from transcription regulator ΞxsA PA1713 [imported] -

SΞQ ID n° 10032 PL-42.1 4749493 to m 753 Pseudomonas aeruginosa (strain PAOl)

4750311 gb|AAG05102.l|AΞ004598_l (AE004598) transcriptional regulator ExsA [Pseudomonas aeruginosa] SEQ ID n~3226 pir| |B83434 translocation protein in type III secretion PA1690 [imported] -

ContigS from

Pseudomonas aeruginosa (strain PAOl)

SEQ ID n° 10033 PL-41.1 4751211 to m 793 gb|AAG05079.l|AΞ004596_5 (AE004596)

4752266 translocation protein in type III secretion

[Pseudomonas aeruginosa] SEQ ID n~3215

SΞQ ID n° 10034

protein S homolog [Yersinia pestis] ref |N _047593.1 | type III secretion protein

[Yersinia pestis] sp | P40298 j SCS_YΞRPS YOP

PROTΞINS TRANSLOCATION PROTΞIN S pir| |T43580 type III secretion protein yscS - Yersinia

Contig9 from pestis plasmid pCDl gb|AAA27679.l| (L25667)

SΞQ ID n° 10035 PL-5272.1 4753048 to m 763 yscS [Yersinia pseudotuberculosis]

4753314 gb|AAC62559.l| (AF053946) Yop proteins translocation protein S homolog [Yersinia pestis] gb|AAC69786.l| (AF074612) type III secretion protein [Yersinia pestis] gb|AAD16829.l| (AF102990) YscS [Yersinia enterocolitica] emb|CAB54922.l| (AL117189) putative type III secretion protein [Yersinia pestis] #N/A pir| |E83434 translocation protein in type III secretion PA1693 [imported] -

Contig9 from

Pseudomonas aeruginosa (strain PAOl)

SΞQ ID n° 10036 PL-39.1 4753317 to 87% gb]AAG05082.l|AΞ004596_8 (AΞ004596)

4753970 translocation protein in type III secretion

[Pseudomonas aeruginosa] SΞQ ID n~3067

Contig9 from ref |NP_052404.l| YSCQ [Yersinia enterocolitica]

SEQ ID n° 10037 PL-38.1 4753967 to m 603 gb|AAD16827.l| (AF102990) YscQ [Yersinia

4754899 enterocolitica] SΞQ ID n~2976

pir|]G83434 translocation protein in type III

Co SEQ—ID n° -10038 PL-37.1 4

protein O [Yersinia pestis] ref |NP_047597.l| type III secretion protein [Yersinia pestis] pir| |T43584 type III secretion protein yscO -

Yersinia pestis plasmid pCDl gb|AAB72198. l|

Contig9 from

(AF020214) YscO [Yersinia pestis]

SEQ ID n° 10039 PL-3385.1 4756038 to 58% gb|AAC62563.l| (AF053946) Yop proteins

4756499 translocation protein O [Yersinia pestis] gb|AAC69790.l| (AF074612) type III secretion protein [Yersinia pestis] emb|CAB54918.l|

(AL117189) putative type III secretion protein

[Yersinia pestis] SΞQ ID n~2619 ref |NP_052401.l| ATPase YscN [Yersinia enterocolitica] sp j P40290 | YSCN_YBRΞN PROBABLΞ

Conti 9 from

ATP SYNTHASΞ YSCN (YOPS SΞCRETION ATPASE)

SEQ ID n° 10040 PL-36.1 4756499 to m 893 pir) |A55520 yscN protein - Yersinia

4757821 enterocolitica gb|AAD16824.l| (AF102990) ATPase

YscN [Yersinia enterocolitica] SEQ ID n~2797 pir]]G83431 outer membrane protein PopN PA1638

[imported] - Pseudomonas aeruginosa

Contig9 from

(strain PAOl) gb|AAC45939.l| (AF010150) PopN

SEQ ID n° 10041 PL-35.1 4758251 to 75%

[Pseudomonas aeruginosa]

4759123 gb|AAG05087.l|AE004597_l (AE004597) outer membrane protein PopN [Pseudomonas aeruginosa] SΞQ ID n~ 714

pir| |H83431 conserved hypothetical protein in type III secretion PA1699 [imported] - Contig9 from Pseudomonas aeruginosa (strain PAθl_)

SEQ ID n° 10042 PL-5276.1 4759104 to 70% gb|AAC45940.l| (AF010150) Perl [Pseudomonas

4759391 aeruginosa] gb|AAG05088.l|AΞ004597_2 (AΞ004597)

conserved hypothetical protein in type III secretion [Pseudomonas aeruginosa] #N/A ref |NP_052398.l| YopN chaperone SycN [Yersinia

Contιg9 from enterocolitica] gb|AAA98431.l| (M32097) unknown

SEQ ID n° 10043 PL-5277.1 4759388 to 69% protein [Plasmid pYV03] gb|AADl682l.l|

4759759 (AF102990) YopN chaperone SycN [Yersinia enterocolitica] #N/A pir| |B83432 conserved hypothetical protein in type III secretion PA1701 [imported]

Contig9 from Pseudomonas aeruginosa (strain PAOl) SΞQ ID n° 10044 PL-5278.1 4759756 to 61% gb]AAC45342.l] (AF010150) Pcr3 [Pseudomonas

4760121 aeruginosa] gb|AAG05090.l|AΞ004597_4 (AΞ004597) conserved hypothetical protein in type III secretion [Pseudomonas aeruginosa] #N/A

Contig9 from gb|AAC45943.l| (AF010150) Pcr4 [Pseudomonas

SΞQ ID n° 10045 PL-5279.1 4760124 to 56% aeruginosa]

4760453 #N/A

Contig9 from dbj |BAA01770.l] (D10998) low calcium response

SΞQ ID n° 10046 PL-3 .1 4760450 to 883 protein [Yersinia enterocolitica]

4762567 SEQ ID n~2630 pir| |B83432 transcription regulator protein PcrR

PA1704 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) gb|AAC45945.1 | SΞQ ID n° 10047 PL-5281.1 4762564 to 683 (AF010150) PcrR [Pseudomonas aeruginosa]

4762998 gb|AAG05093.1 | E004597_7 (AE004597) transcriptional regulator protein PcrR

[Pseudomonas aeruginosa] #N/A

pir]|F83432 regulator in type III secretion

SEQ ID n° 10048 PL-5283.1

aeniginosa]- #N/A_

Contig9 from sp|P21206|LCRV_YERPΞ VIRULΞNCE-ASSOCIATΞD V SEQ ID n° 10049 PL-33.1 4763329 to 67% ANTIGΞN (LOW CALCIUM RESPONSE LOCUS PROTEIN

4764243 V) pir| |B33601 IcrV protein - Yersinia pestis SEQ ID n~2545 Contig9 from gb[AAC45936-τl|—(AF010149) PcrH [Pseudomonas SΞQ ID n° 10050 PL-3386.1 4764253 to 81% aeruginosa]

4764756 SEQ ID n~2620

Contig9 from gb|AAC46212.l| (AF035922) PepB [Pseudomonas

SEQ ID n° 10051 PL-32.1 4764743 to 61% aeruginosa]

4765921 SEQ ID n~2450

Contig9 from gb|AAC462l3.l| (AF035922) PepD [Pseudomonas

SEQ ID n° 10052 PL-31.1 4765933 to 633 aeruginosa]

4766817 SEQ ID n~2339

Contig9 from

ΞΞQ ID n° 10053 PL-5285.1 4766836 to No Hits found

4767207 #N/A sp|P26995|ΞXSC_PSΞAE ΞXOENZYME S SYNTHESIS

PROTΞIN C PRΞCURSOR pir| |A41047 exsC protein -

Pseudomonas aeruginosa pir| |C83433 exoenzyme S synthesis protein C precursor PA1710 [imported]

Contig9 from

Pseudomonas aeruginosa (strain PAOl) SΞQ ID n° 10054 PL-5286.1 4767204 to 75% gb|AAA25814.l| (M64975) S synthesis trans-

4767641 regulatory protein [Pseudomonas aeruginosa] gb] AAG05099.1 | AΞ004597_13

(AΞ004597) exoenzyme S synthesis protein C precursor [Pseudomonas aeruginosa] #N/A

Contig9 from SEQ ID n° 10055 PL-5287.1 4767638 to No Hits found

4767871 #N/A

ref |NP_052409.l| lipoprotein VirG (YscW)

Contig9 from [Yersinia enterocolitica] gb|AAD16832.1 | SEQ ID n° 10056 PL-5288.1 4767868 to p 603 (AF102990) lipoprotein VirG (YscW) [Yersinia

4768254 enterocolitica] prf ( | 2117313A lipoprotein

[Yersinia enterocolitica] #N/A

Sp|P11290 |YIBD_ECOLI HYPOTHETICAL 40.5 KDA

PROTEIN IN SΞCB-TDH INTERGENIC REGION pir| |S47836 hypothetical protein f344 -

Contig9 from

Escherichia coli pir| |Q3ECTH hypothetical 40.5K SEQ ID n° 10057 PL-30.1 4769131 to p 393 protein (secB-tdh 5' région) - Escherichia coli

4770120 gb|AAB185S2.l| (U0003S) alternate^" gène name yibD

[Escheπchia coli] gb]AAC76639.l| (AΞ00043S) putative regulator [Escherichia coli K12] SEQ ID n~2229

Contig9 from ref |NP_037752.l| holin [Bacteriophage HK37] SΞQ ID n° 10058 PL-5289.1 4770485 to p 63% gb|AAF310S6.l|AF063529_9 (AF069529) holin

4770811 [Bacteriophage HK97] #N/A ref |NP_049909.l | structural protein P5

Contig9 from

[Alteromonas phage PM2] SEQ ID n° 10059 PL-5290.1 4770821 to p 59% gb|AAD43555.l[AF155037_18 (AF155037) Structural

4771222 protein P5 [Alteromonas phage PM2] #N/A

Contig9 from emb CAA09702.1 (AJ011579) gpl5 [bacteriophage SEQ ID n° 10060 PL-3387.1 4771232 to p 58% PS3]

4771681 SEQ ID n~2621 sp|P37479]YYCE_BACSU HYPOTHETICAL 15.6 KD

PROTEIN IN PURA-DNAC INTERGΞNIC REGION

Contig9 from pir||S65969 yycΞ protein - Bacillus subtilis SEQ ID n° 10061 PL-3388.1 4771770 to m 40% dbj |BAA05175.1| (D26185) unknown [Bacillus

4772165 subtilis] emb|CABl6080.l| (Z99124) yycE

[Bacillus subtilis] SEQ ID n~2622 sp | Q 8450 | YC04_KLEPN PUTATIVΞ CAPSULΞ

POLYSACCHARIDE EXPORT PROTEIN PRECURSOR (ORF4)

Contig9 from pir| JB56146 probable polysaccharide export SEQ ID n° 10062 PL-29.1 4772846 to p 753 protein precursor - Klebsiella

4773991 pneumoniae dbj |BAA04775.1 | (D21242) ORF4

[Klebsiella pneumoniae] SEQ ID n~2118

sp|Q46630|AMSI_ΞRWAM PROBABLB LOW MOLBCULAR

SEQ ID n° 1006

SEQ ID n° 1006

pir] |T47009 hypothetical protein tehB [imported] - Yersinia pestis emb|CAA21352.l| (AL031866]

ORF29, len: 295 aa, probable tellurite

Contig9 from résistance protein (tehB) , highly SΞQ ID n° 10065 PL-27.1 4776876 to 66% similar to many, eg.

4777733 P25397|TEHB_ΞCOLI (197 aa) . 61.3% identity in

191 aa overlap Fasta scores: opt:

792, Ξ(): 0 or U32807_6 Haemophilus influenzae (286 a a), 58.2% ide> SEQ ID n~2898

Contig9 from emb|CAB81024.l| (AL161576) putative protein SΞQ ID n° 10066 PL-26.1 4777778 to m 623 [Arabidopsis thaliana]

4779370 SEQ ID n~2791 pir| |F83328 probable sodium.-alanine symporter

PA2533 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SΞQ ID n° 10067 PL-25.1 4780110 to 71% gb|AAG05921.l|AE004681_3 (AΞ004681) probable

4781477 sodium: alanine symporter [Pseudomonas aeruginosa] SEQ ID n~2684

Contig9 from gb|AAD45415.l| (U65001) salicylaldehyde SEQ ID n° 10068 PL-24.1 4781523 to m 653 dehydrogenase [Sphingomonas sp.]

4783007 SEQ ID n~2574 Contig9 from gb|AAK03233.l| (AEO06155) unknown [Pasteurella SEQ ID n° 10069 PL-23.1 4783573 to 33% multocida]

4784709 SEQ ID n~2466 Contig9 from SEQ ID n° 10070 PL-3383.1 4785112 to No Hits found

4785558 SEQ ID n~2623

Contig9 from gb|AAA85578.l| (U23806) extended ORF of gtE -SΞQ ID n° 10071 PL-22.1 4785981 to p - —7-7% gène; transcription from this start

4787051 point is unlikely [Providencia stuartii] SEQ ID n~2356 pir| |C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) _ -SEQ ID n° 10072 PL-21.1 4787565=t-0- -m-= -3-83 gb|AAG04736.l|AΞOÔ4564T5 (AE004564) probable

4788230 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~2246 pir||C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SΞQ ID n° 10073 PL-20.1 4789354 to 44% gb|AAG04736.l|AΞ004564_5 (AΞ004564) probable

4790028 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~2137

Contig9 from SEQ ID n° 10074 PL-5296.1 4790057 -to No Hits found

4790266 #N/A pir| |G82090 transcription regulator Lad family

Contig9 from VC2337 [imported] - Vibrio cholerae SEQ ID n° 10075 PL-19.1 4790259 to 603 (group Ol strain N16961) gb| AAF95481.1 |

4791260 (AE004303) transcriptional regulator, Lad family [Vibrio cholerae] SEQ ID n~2027 sp|Q57007|YB07_HAΞIN HYPOTHΞTICAL NA+/H+

ANTIPORTER HI1107 pir| | 164182 Na+/H+-exchanging

Contig9 from protein homolog - Haemophilus influenzae SEQ ID n° 10076 PL-18.1 4791418 to 67%

(strain Rd KW20) gb] AAC22762.l|

4792872

(U32790) Na+/H+ antiporter (nhaC) [Haemophilus influenzae Rd] SEQ ID n~920

sp|Q08432|PATB_BACSU PUTATIVE AMINOTRANSFERASE B

Co SEQ ID n° 10077 PL-17.1 4

ContigS from gb|AAF22961.l|AF157489_l (AF157489) Pin SEQ ID n° 10078 PL-5300.1 4734171 to m 82% [Photorhabdus luminescens-]

4794383 #N/A pir] |B82381 transcription regulator LuxR family

Contig9 from VCA1078 [imported] - Vibrio cholerae SEQ ID n° 10079 PL-3390.1 4795073 to p 39% (group 01 strain N16961) gb|AAF96971.1 |

4795639 (AEO04433) transcriptional regulator, LuxR family [Vibrio cholerae] SEQ ID n-2625

Contig9 from dbj |BAB06239.l| (AP001515) transposase related SEQ ID n° 10080 PL-16.1 4795682 to p 21% protein (20) [Bacillus halodurans]

47S6707 SEQ ID n~700 Contig9 from gb|AAG56458.l|AE005372_3 (AE005372) putative SEQ ID n° 10081 PL-15.1 4737245 to m 69% transcriptional regulator LYSR-type

4798144 [Escherichia coli 0157 :H7] SEQ ID n~391 Contig9 from sp | P77357 | BGA_ECOLI AMINOBBNZOYL-GLUTAMATE SEQ ID n° 10082 PL-14.1 4798419 to p 75% UTILIZATION PROTEIN A

4799741 SEQ ID n~480 Contig9 from gb|AAG56460.l|AΞ005372_5 (AΞ005372) orf, SEQ ID n° 10083 PL-13.1 4799734 to p 73% hypothetical protein [Escherichia coli 0157 :H7]

4801182 SEQ ID n~373 s ] P46133 | ABGT_ΞCOLI AMINOBΞNZOYL-GLUTAMATΞ

Contig9 from TRANSPORT PROTΞIN pir| |C64883 membrane protein SEQ ID n° 10084 PL-12.1 4801292 to p 82% ydaH - Escherichia coli gb |AAC74418. l|

4802818 (AΞ000231) putative pump protein (transport)

[Ξscherichia coli K12] SEQ ID n~263

pir]|C83477 probable transcription regulator

SEQ ID n° 10085 PL-5304

SEQ ID n° 10086 PL-11.

pir| |C83477 probable transcription regulator

PA134^~7 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 10087 PL-10.1 4805130 to 41% gb|AAG04736.l|AΞ004564_5 (AE004564) probable

4805822 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~43 pιr| |B82381 transcription regulator LuxR family

Contig9 from VCA1078 [imported] - Vibrio cholerae SEQ ID n° 10088 PL-9.1 4805876 to 433 (group 01 strain N16961) gb| AAF96971.l|

4806556 (AE004433) transcriptional regulator, LuxR family [Vibrio cholerae] SEQ ID n~3746

ContigS from SEQ ID n° 1008S PL-5306.1 4806598 to No Hits found

4806909 #N/A pir[|F82543 outer membrane hemolysin activator protein XF2550 [imported] - Xylella

Contig9 from fastidiosa (strain 9a5c) SEQ ID n° 10090 PL-8.1 4807365 to 56% gb|AAF85347.l|AΞ004062_2 (AE004062) outer

4809029 membrane hemolysin activator protein [Xylella fastidiosa] SEQ ID n~3637 pir| |F81045 hemagglutinin/hemolysin-related protein NMB1768 [imported] -

Contig9 from

Neisseria meningitidis (group B strain MD58) SEQ ID n° 10091 PL-6.1 4809078 to 35% gb|AAF42109.l| (AE002526)

4818161 hemagglutmin/hemolysm-related protein

[Neisseria meningitidis MC58] SEQ ID n~3422

pir| |D81221 hypothetical protein NMB0237

ContigS from [imported] - Neisseria meningitidis

SEQ ID n° 10032 PL-5311.1 4818176 to 443 (group B strain MD58) gb|AAF40692 -l| (AE002381)

4818523 hypothetical protein [Neisseria meningitidis

sp|P39394 |YJIW_ΞCOLI HYPOTHETICAL 14.6 KD

PROTEIN IN MCRB-HSDS ^{^}INTERGENIC^" REGION

(F132) pir| |S56573 hypothetical 14.6K protein

ContigS from

(mcrB-hsdS intergenic région) - SEQ ID n° 100S3 PL-5312.1 4818576 to m 433

Escherichia coli gb | AAA97244.1 | (U14003)

4818803 --

ORF_fl32 [Escherichia colïT gb|ÀAC77303.1 |

(AΞ000505) orf, hypothetical protein

[Ξscherichia coli K12] #N/A pir||C83640 probable transcription regulator

PA0048 [imported] - Pseudomonas

ContigS from aeruginosa (strain PAOl) SEQ ID n° 100S4 PL-7363.1 4818876 to m 343 gb|AAG03438.l]AE004444_7- (AEO04444) probable

4819271 transcriptional regulator [Pseudomonas aeruginosa] #N/A sp|P47762|PRIM_LISMO DNA PRIMASΞ gb| AAC43305.1 |

ContigS from

(U13165) DNA primase [Listeria monocytogenes]

SEQ ID n° 10095 PL-7362.1 4819371 to 163 prf | |2104269B DNA primase [Listeria

4822688 monocytogenes] #N/A

Contig9 from gb|AAF89876.l| (AF173869) putative site-specific

SEQ ID n° 10096 PL-3129.2 4822675 to 31% recombinase XerD [staphylococcus

4823805 aureus] #N/A

Contig9 from

SEQ ID n° 10097 PL-6889.1 4823998 to No Hits found

4824129 #N/A

Contig9 from

SEQ ID n° 10098 PL-5649.4 4824159 to m No Hits found

4824353 #N/A

Contig9 from pdb|lF3l|A Chain A, Crystal Structure Of Tn5

SEQ ID n° 10099 PL-3497.5 4824337 to 57% Transposase Complexed With Transposon

4825719 End Dna #N/A

Contig9 from gb|AAD27742.l|AF132967_l (AF132967) CGI-33 SEQ ID n° 10100 PL-6896_^-2- 4825792 to m 22? protein [Homo sapiens] 4826235 -#N/A SEQ ID n° 101

SEQ ID n° 10102 PL-6912.2 4827317 to m No Hits found

4827625 #N/A

Contig9 from gb|AAF51932.l| (AE003601) CG14677 gène product

SEQ ID n° 10103 PL-3187.2 4827539 to 183

[Drosophila melanogaster]

4828351 #N/A

Contig9 from

SEQ ID n° 10104 PL-6929.1 4828348 to No Hits found

4828665 #N/A sp|P39394]YJIW_ECOLI HYPOTHETICAL 14.6 KD

PROTEIN IN MCRB-HSDS INTERGENIC REGION

(F132) pir| |S56573 hypothetical 14.6K protein

Contig9 from

( crB-hsdS intergenic région) - SEQ ID n° 10105 PL-6486.1 4828710 to 383

Escherichia coli gb|AAA97244.l| (U14003)

4828952

ORF_fl32 [Escherichia coli] gb | AAC77303.1 |

(AΞ000505) orf, hypothetical protein

[Escherichia coli K12] #N/A sp| 034419 |RSR1_VIBCH CRYPTIC PHAGE CTXPHI

TRANSCRIPTIONAL REPRESSOR RSTR pir| |H82197 transcription repressor RstR VC1464 VC1455

[imported] - Vibrio cholerae (group

Contig9 from

01 strain N16S61) gb|AAB81724.l| (U837S5) RstR

SEQ ID n° 10106 PL-6898.2 4829045 to m 483

[Vibrio cholerae] gb| AAB81728.1 j (U837S6) RstR

4829416

[Vibrio cholerae] gb[AAF9461 .1 | (AE004224) transcriptional repressor RstR [Vibrio cholerae] gb|AAFS4621.l| (AE004224) transcriptional repressor RstR [Vibrio cholerae] #N/A

Contig9 from dbj |BAB05034.l| (AP001511) DNA primase [Bacillus SΞQ ID n° 10107 PL-3126.4 4829516 to 153 halodurans]

4832830 #N/A

pir| |F83177 integrase/recombinase XerD PA3738

Contig9 from [imported] - Pseudomonas- - aeruginosa

SBQ_.ID n° 10108 PL-2.3 4832817 to 373 (strain PAOl) gb |AAG07125.1 | E004793_2

4833S47 (AΞO04793) integrase/recombinase XerD

[Pseudomonas aeruginosa] #N/A

Contig9 from SΞQ ID n° 10109 PL-7360.1 483 218^~to m No Hits found

4834319 #N/A Contig9 from SΞQ ID n° 10110 PL-7359.1

ContigS from gb|AAF51932.l| (AE003601) CG14677 gène product SΞQ ID n° 10111 PL-7356.1 4834907 to 17% [Drosophila melanogaster]

4835719 #N/A Contig9 from SEQ ID n° 10112 PL-6922.1 4835716 to No Hits found

48-36033 #N/A

Sp|P39394 |YJIW_ECOLI HYPOTHBTICAL 14.6 KD

PROTEIN IN MCRB-HSDS INTERGENIC REGION

(F132) pir||S56573 hypothetical 14.6K protein

Contig9 from

(mcrB-hsdS intergenic région) - SEQ ID n° 10113 PL-5719.1 4836078 to 38%

Bscherichia coli gb| AAA97244. l| (U14003)

4836320

ORF_fl32 [Escherichia coli] gb| AAC77303.l|

(AE000505) orf, hypothetical protein

[Escherichia coli K12] #N/A sp|034419|RSRl_VIBCH CRYPTIC PHAGE CTXPHI

TRANSCRIPTIONAL REPRESSOR RSTR pir| |H82197 transcription repressor RstR VC1464 VC1455

[imported] - ibrio cholerae (group

ContigS from

01 Strain N16961) gb |AAB81724.1 | (U83795) RstR SEQ ID n° 10114 PL-5720.1 4836413 to m 48%

[Vibrio cholerae] gb] AAB81728.1 ] (U837S6) RstR

4836784

[Vibrio cholerae] gb| AAF34612.l| (AE004224) transcriptional repressor RstR [Vibrio cholerae] gb| AAF34621.l| (AE004224) transcriptional repressor RstR [Vibrio cholerae] #N/A

sp|P47762|PRIM_LISMO DNA PRIMASE gb | AAC43305.1 |

Contig9 from

(U13165) DNA primase [Listeria monocytogenes] SΞQ ID n° 10115 PL-3159.2 4836884 to 17% prf | |2104269B DNA primase [Listeria 4840198 monocytogenes] #N/A pir||F83177 integrase/recombinase XerD PA3738

Contιg9 from _[imported] - Pseudomonas aeruginosa

SEQ ID n° 10116 PL-3047.1 4840185 to 38% (Strain PAOl) gb|AAG07125.l|AÈ004793_2

4841297 (AE004793) integrase/recombinase XerD

[Pseudomonas aeruginosa] SEQ ID n~2281

Contig9 from SΞCTlD n° 10117 PL-6341.1 4841586 to m No Hits found

4841687 #N/A Contig9 from SEQ ID n° 10118 PL-4044.1 4841672 to m No Hits found

4842109 SEQ ID n~3192 Contig9 from SEQ ID n° 10119 PL-5706.1 4842373 to No Hits found

4842642 #N/A Contig9 from gb|AAG58075.l|AE005525_l (AE005525) sprT gène SEQ ID n° 10120 PL-3048.1 4843051 to m 69% product [Escherichia coli 0157 :H7]

4843635 SΞQ ID n~2282 sp | P04384 | METK_ΞCOLI S-ADΞNOSYLMΞTHIONINE

SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE)

(ADOMET SYNTHΞTASΞ) pir| | SYΞCSM methionine adenosyltransferase (EC 2.5.1.6) [validated] -

Ξscherichia coli gb| AAA69109.l| (U28377) CG

Site No. 507 [Ξscherichia coli] gb|AAC75979.l|

Contig9 from

(AE000377) methionine adenosyltransferase 1 SEQ ID n° 10121 PL-3043.1 4843784 to m 923

(AdoMet synthetase) ; methyl and

4844956 propylamine donor, corepressor of met gènes

[Escherichia coli K12] gb|AAG58073.1 | Ξ005524_S

(AE005524) methionine adenosyltransferase 1

(AdoMet synthetase) ; methyl and propylamme donor, corepressor of met gènes

[Escheπchia coli 0157 :H7] SEQ ID n~2283

Contig9 from SEQ ID n° 10122 PL-5705.1 4845249 to No Hits found

4845461 #N/A pir| (A65079 arginine decarboxylase (EC 4.1.1.19)

Contig9 from - Escherichia coli gb | AAA69105.l| (U28377) CG

SEQ ID n° 10123 PL-3050.1 4845588 to 883 Site No. 161 [Escherichia coli] gb|AAC75975. ι|

^{~~ ~} 4847492 (AΞO 00377^") biosynthetic arginine decarboxylase

[Escherichia coli K12] SEQ ID n~2285 sp|P16936|SPEB_ECOLI AGMATINASE (AGMATINE

UREOHYDROLASE) (AUH) pir|]C42604 agmatinase (EC

3.573711) [validated] - Ξscherichia coli ^"

ContigS from gb|AAA83909.l| (M32363) agmatine ureohydrolase SEQ ID n° 10124 PL-3051.1 4847662 to 883 [Ξscherichia coli] gb|AAA69104.1 | (U28377)

4848585 agmatine ureohydrolase [Escherichia coli] gb[AAC75974.l| (AΞ000377) agmatinase

[Ξscherichia coli K12] gb| AAG58067.1 | AΞ005524_3

(AE005524) agmatinase [Escherichia coli 0157.-H7] SEQ- ID n~2286 sp|Q4693l|YGDQ_ECOLI HYPOTHΞTICAL 26.2 KD

PROTΞIN IN MUTH-TAS INTERGΞNIC REGION

Contig9 from pir| |A65066 hypothetical protein b2832 - SEQ ID n° 10125 PL-3052.1 4848848 to m Escherichia coli (strain K-12) gb | AAB40479.1 |

4849561 (U29581) ORF_o237 [Escherichia coli] gb|AAC75871.l[ (AΞ000367) putative transport protein [Escherichia coli K12] SEQ ID n~2287 gb]AAG57943.l|AE005512_2 (AE005512) methyl-

Contig9 from directed mismatch repair [Ξscherichia coli SEQ ID n° 10126 PL-3053.2 4849654 to m 803 0157:H7 ΞDL933] dbj ] BAB37111.1 | (AP002563)

4850340 methyl-directed mismatch repair [Bscherichia coli 0157 :H7] #N/A

Contig9 from sp|P33595|YABN_ECOLI HYPOTHETICAL 63.9 KDA SEQ ID n° 10127 PL-3054.2 4850925 to m 723 PROTEIN IN TBPA-LEUD INTERGENIC REGION

4852586 (ORF103) #N/A

sp | P30126 ] LEUD_ΞCOLI 3 -ISOPROPYLMALATE

DEHYDRATASΞ SMALL SUBUNIT (ISOPROPYLMALATE

ISOMERASE) (ALPHA-IPM ISOMERASΞ) (IPMI)

Contig9 from pir||S40585 3-isopropylmalate dehydratase (EC

SEQ ID n° 10128 PL-3055.1 4853031 to 79% 4.2.1.33) small chain - Escherichia

4853636 coli dbj |BAA0l340.l| (P10483) leuD protein homolog (PÎR.-S07306) [Escherichia coli] gb|AAC73l82.l| (AE000117) isopropylmalate isomerase subunit [Escherichia coli K12] SEQ ID n~2290 pir) |H64728 3 -isopropylmalate dehydratase (EC

Contig9 from^" 4.2.1.33) alpha chain - Escherichia

SΞQ ID n° 10129 PL-3056.1 4853645 to m 89% coli gb|AAC73183.l] (AE000117) 3-

4855054 isopropylmalate isomerase (dehydratase) subunit

[Escherichia coli K12] SEQ ID n~2291 sp | P37412 | LEU3_SALTY 3 -ISOPROPYLMALATΞ

DΞHYDROGENASΞ (BBTA-IPM DΞHYDROGΞNASΞ) (IMDH)

(3-IPM-DH) pdb|lCNZ|A Chain A, 3-

Contig9 from Isopropylmalate Dehydrogenase (Ipmdh) From

SEQ ID n° 10130 PL-3057.1 4855056 to m 85% Salmonella Typhimurium pdb | 1CN ( B

4856147 Chain B, 3 -Isopropylmalate Dehydrogenase (Ipmdh)

From Salmonella Typhimurium gb|AAB60185.l| (U20795) 3 -isopropylmalate dehydrogenase [Salmonella typhimurium] SEQ ID n~2292 sp | P09151 | LEU1_ΞC0LI 2 -ISOPROPYLMALATΞ SYNTHASΞ

(ALPHA-ISOPROPYLMALATE SYNTHASE)

Contig9 from

(ALPHA-IPM SYNTHETASE) pir| |B64729 2- SΞQ ID n° 10131 PL-3058.1 4856150 to m 84% isopropylmalate synthase (EC 4.1.3.12) -

4857712

Escherichia coli gb| AAC73185.l| (AE000117) 2- isopropylmalate synthase [Escherichia coli K12] SEQ ID n~2293

Contig9 from gb|AAD26693.l|AF117227_5 (AF117227) LeuO

SEQ ID n° 10132 PL-3059.1 4858670 to 70% [Salmonella typhimurium]

4859614 SEQ ID n~2294

pir| |H82069 probable long-chain-fatty-acid--CoA

Co SEQ ID n°—10-1-33-PL--2-7-7-1-.2 4

^""pir| |H69778 hypothetical protein ydeN - BaciTlus

Contig9 from subtilis dbj |BAA19361.1 | (AB001488) FUNCTION SEQ ID n° 10134 PL-3514.1 4861972 to 49%

UNKNOWN. [Bacillus subtilis] emb|CAB12333.l|

4862541

(Z99106) ydeN [Bacillus subtilis] SEQ ID n~2726

Contig9 from pir| |G71856 hypothetical protein jhp!045 ^ SEQ ID n° 10135 PL-2770.1 4862698 to m 313 Helicobacter pylori (strain J99) gb| AAD06623.l|

4863324 (AΞ001532) putative [Helicobacter pylori J99] SΞQ ID n-2977 sp|P55126|FRPA_NΞIMC IRON-RΞGULATED PROTEIN FRPA

Contig9 from pir||A47058 Fe-regulated RTX cytotoxin homolog SEQ ID n° 10136 PL-276S.2 4863334 to m 243 FrpA - Neisseria meningitidis gb| AA2545 .1 |

4864593 (L06302) iron-regulated protein [Neiss_eria meningitidis] #N/A pir| |F81828 probable periplasmic type I secretion system protein NMA1995

ContigS from [imported] - Neisseπa meningitidis (group A SEQ ID n° 10137 PL-3513.2 4864678 to m 25% strain Z2491) emb | CAB85214.1 |

4865115 (AL162757) putative periplasmic type I secretion system protein [Neisseria meningitidis Z2491] #N/A

ContigS from SEQ ID n° 10138 PL-7352.1 4865606 to m No Hits found

4865683 #N/A pir| |YCEC3I acetolactate synthase (ΞC 4.1.3.18)

Contig9 from III large chain - Ξscherichia coli SEQ ID n° 10139 PL-2768.1 4865998 to 86% gb[AAC73l88.l| (AΞO00118) acetolactate synthase

4867752 III, valine sensitive, large subunit

[Escherichia coli K12] SEQ ID n~î974

Contig9 from gb|AAF65177.l|AF117227_2 (AF117227) IlvH SEQ ID n° 10140 PL-3512.1 4867755 to 89% [Salmonella typhimurium]

4868246 SEQ ID n~2724

sp|P21930 ]FRUR_SALTY FRUCTOSE REPRESSOR

(CATABOLITE REPRESSOR/ACTIVATOR) pir| |S15941

PEP- -fructosephosphotransferase system repressor

- Salmonella typhimurium

Contig9 from emb|CAA33103.l| (X55456) PEP: fructose SEQ ID n° 10141 PL-2767.1 4868334 to 303

phosphotransferase system repressor

-—486-934-1

[Salmonella typhimurium] gb]AAF65176.l|AF117227_l (AF117227) FruR

[Salmonella typhimurium] prf | | 1712316F fruR gène [Salmonella typhimurium] SEQ ID n~2973

Cδhtig9 from gb]AAG54385.l|AE005185_2 (AE005185) orf,

SΞQ ID n° 10142 PL-3511.1 4863S73 to 73% hypothetical protein [Escherichia coli 0157 :H7]

4870431 SEQ ID n~2723

ContigS from pir| |QQECFT yabc protein - Ξscherichia coli

SΞQ ID n° 10143 PL-2766.1 4870434 to 82% dbj |BAA01348.l( (D10483) ORF [Ξscherichia coli]

4871378 SEQ ID n~2972 sp|P22187|FTSL_ΞCOLI CELL DIVISION PROTEIN FTSL pir| |A45278 cell division protein ftsL -

Escherichia coli emb |CAA38860.1 | (X55034) OrfA protein [Escherichia coli] gb|AAA24299.1 |

(K00137) orfA gène [Escherichia coli] gb|AAB24309.l] (S49875) FtsL=cytoplasmic membrane cell division protein

Contig9 from [Ξscherichia coli, Peptide, 121 aa]

SEQ ID n° 10144 PL-56SS.1 4871378 to 82% gb|AAB24311.l| (S49802) MraR≈cell cycle

48716S5 regulator [Escherichia coli, Peptide, 121 aa] gb|AAC73194.l| (AΞ000118) cell division protein; ingrowth of wall at septum

[Ξscherichia coli K12] gb | AAG54387.1 | AΞ005185_4

(AΞ005185) cell division protein; ingrowth of wall at septum [Ξscherichia coli

0157 :H7] prf | | 1S04252A ftsL gène [Escherichia coli] #N/A

sp|P04286|PBP3_ECOLI PΞNICILLIN-BINDING PROTEIN

3 PRECURSOR (PBP-3) pir[]zPECP3 penicillin- binding protein 3 precursor - Escherichia coli emb|CAA38861.l| (X55034) Pbp3 protein [Ξscherichia coli] gb|AAA24300.1 | (K00137)

penicillin-binding protein 3 [Ξscherichia coli]

Contig9 from dbj |BAA0134S.lj (D10483) penïcïïlin-binding SEQ ID n° 10145 PL-2765.1 4871724 to protein 3 precursor [Escherichia coli]

4873490 gb|AAC73195.l| (AE000118) septum formation; penicillin-binding protein 3 ; peptidoglycan synthetase [Es^hcërïchia coli K12] gb]AAG54388.l|AE005185_5 (AE005185) septum formation; penicillin-binding protein 3; peptidoglycan synthetase [Escherichia coli

0157 :H7] SEQ ID n~2971

Contig9 from gb]AAG54389.l|AE005185_6 (AE005185) raeso- SEQ ID n° 10146 PL-2764.1 4873477 to 823 diaminopimelate-adding enzyme [Escherichia coli

4874964 0157 :H7] SEQ ID n~£S 70 sp [ 11880 | MURF_ΞCOLI UDP-N-ACΞTYLMURAMOYLALANYL-

D-GLUTAMYL-2, 6-DIAMIN0PIMΞLATΞ--D-

ALANYL-D-ALANYL LIGASΞ (UDP-MURNAC-

PΞNTAPEPTIDE SYNTHETASE) (D-ALANYL-D-

ALANINE-ADDING ENZYME) pir|]F64730 UDP-N-

Contig9 from acetylmuramoylalanyl-D-glutamyl-2 , 6-

SΞQ ID n° 10147 PL-2763.1 4874961 to 733 diaminopimelate--D-alanyl-D-alanine ligase (EC

4876340

6.3.2.15) precursor - Ξscherichia coli gb|AAC44657.l| (U67891) UDP-MurNAc-Tripeptide.-D-

Ala-D-Ala-Adding enzyme [Escherichia coli] gb|AAC73197.l[ (AE000118) D-alanine:D- alanine-adding enzyme [Escherichia coli K12] SEQ ID n-2969

Contig9 from gb|AAG54391.l|AE005185_8 (AΞ005185) phospho-N-

SEQ ID n° 10148 PL-2762.1 4876334 to 903 acetylmuramoyl-pentapeptide transferase?

4877416 [Ξscherichia coli 0157 :H7] SEQ ID n~2968

sp | P14900 | MURD_ΞCOLI UDP-N-ACETYLMURAMOYLALANINE- -D-GLUTAMATΞ LIGASE (UDP-N-

ACΞTYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)

(D-GLUTAMIC ACID ADDING ENZYME) pir[ | CΞECME UDP- N-acetylmuramoylalanine--D-glutamate ligase (ΞC

6.3.2.9) - Escherichia coli

^"ContigS from emb|CÀA38865^~l| (X55034) UDP-MurNac-L-Ala-D-Glu

SEQ ID n° 10149 PL-2761.1 4877419 to 76% (MurD) (AA 1-438) [Escherichia coli]

4878729 emb|CAA35933.l| (X51584) murD gène product (AA 1-

438) [Escherichia coli] dbj |BAA01353.l|

(D10483) UDP-N-acetylmuramoylalanine-D-glutamate ligase [Escherichia coli] gb|AAC73199.l| (AE000118) UDP-N- acetylmuramoylalanine-D-glutamate ligase

[Escherichia coli K12] SEQ ID n-2967 sp|P16457|FTSW_ECOLI CELL DIVISION PROTEIN FTSW

-pir||CEECFW cell division protein ftsW -

Escherichia coli emb |CAA38866. l| (X55034) FtsW protein [Escherichia coli] gb]AAA83859.l]

(M30807) cell division protein [Escherichia

Contig9 from coli] dbj |BAA0l354.l| (D10483) cell division SEQ ID n° 10150 PL-2760.1 4878729 to 87% protein ftsW [Escherichia coli] gb|AAC73200. l|

4879922 (AΞ000118) cell division; membrane protein involved in shape détermination

[Escherichia coli K12] gb|AAG54393.l|AE005185_10 (AE005185) cell division; membrane protein involved in shape détermination [Escherichia coli 0157:H7] SEQ ID n~2966 pdb|lF0K|A Chain A, The 1.9 Angstrom Crystal

Contig9 from

Structure Of E. Coli Murg pdb|lF0K|B Chain B,

SΞQ ID n° 10151 PL-2759.1 4879919 to

The 1.9 Angstrom Crystal structure Of E. Coli

4880986

Murg SEQ ID n~2964

sp | P1795 | MURC_ΞCOLI UDP-N-ACETYLMURAMATE- - ALANINE LIGASE (UDP-N-ACETYLMURAMOYL-

L-ALANINE SYNTHETASΞ) pir | | CΞECAM UDP-N- acetylmuramate--alanine ligase (EC 6.3.2.8) - Escherichia coli emb | CAA38868.1 |

(X55034) UDP-N-acetylmuramate- -alanine ligase

Contig9 from [Escherichia coli] emb]CAA36868.l] (X52644) SEQ ID n° 10152 PL-2758.1 4881042 to 843 (UDP-N-acetylmuramate: L-alanine ligase) (AA 1-

4882517 491) [Escherichia coli] dbj |BAA0l356.l| (D10483) UDP-N-acetylmuramate- alanine ligase [Escherichia coli] gb|AAC73202.l| (AE000118) L-alanine adding enzyme, UDP-N-acetyl-muramate : alanine ligase [Escherichia coli K12] prf | |l808265A murC gène [Ξscherichia coli] SΞQ ID n~2963 sp|P07862|DDLB_ECOLI D-ALANINE--D-ALANINΞ LIGASE

B (D-ALANYLALANINE -SYNTHETASE) (D-ALA-

D-ALA LIGASE) pir| | CEECDL D-alanine--D-alanine ligase (EC 6.3.2.4) B - Escherichia coli pdb|lIOv| Complex Of D-Ala:d-Ala Ligase With

Adp And A Phosphoryl Phosphonate pdb|2DLN| Mol_id: 1; Molécule.- D-Alanine--D-

Contig9 from Alanine Ligase; Chain: Null; Ec: SΞQ ID n° 10153 PL-2757.1 4882510 to 823 6.3.2.4 emb|CAA38869.l| (X55034) D-Ala:D-Ala

4883430 ligase (Ddl) [Escherichia coli] gb| AAA23672.1 | (M14029) ddl cell wall enzyme [Escherichia coli] gb|AAA23815.l| (K02668) D-alanine :D-alanine ligase [Escherichia coli] dbj |BAA01357.1 | (D10483) D-alanine-D-alanine ligase [Escherichia coli] gb|AAC73203.l| (AΞ000118) D-alanine-D- alanine ligase B, affects cell division [Escherichia coli K12] SΞQ ID n~2962

sp[P06136|FTSQ_ECOLI CELL DIVISION PROTEIN FTSQ pir| |CEECQ cell division protein ftsQ -

JEscherichia coli emb | CAA38870.11 (X55034) FtsQ protein [Escherichia coli] emb | CAA26589.1 |

Contig9 from (X02821) put. ftsA protein [Escherichia coli]

SEQ ID n° 10154 PL-2756.1 4883432 to 743 gb|AAA23816.l| (K02668) ftsQ protem

4884238 [Escherichia coli] dbj |BAA01358.l| (D10483) cell division protein ftsQ [Ξscherichia coli] gb|AAC73204.l| (AΞ000118) cell division protein; ingrowth of wall at septum

[Escherichia coli K12] SEQ ID n~2961 sp|P06137|FTSA_ECOLI CELL DIVISION PROTEIN FTSA pir] | CΞΞCA cell division protein ftsA -

Ξscherichia coli emb |CAA38871. l| (X55034) FtsA protein [Ξscherichia coli] emb |CAA26590.1 |

(X02821) ftsA protein [Ξscherichia coli] dbj |BAA01359.l| (D10483) cell division protein ftsA [Ξscherichia coli] gb] AC73205.1 |

Contig9 from

(AΞ000118) ATP-binding cell division protein, SEQ ID n° 10155 PL-2755.1 4884280 to 943 septation process, complexes with

4885536

FtsZ, associated with junctions of inner and outer membranes [Escherichia coli K12] gb|AAG54398.l|AΞ005186_4 (AE005186) ATP-binding cell division protein, septation process, complexes with FtsZ, associated with junctions of inner and outer membranes

[Escherichia coli 0157 :H7] SEQ ID n~2960 pir| |CEECZ cell division protein ftsZ -

Escherichia coli gb | AAC73206.1 | (AE000119) cell division; forms circumferential ring; tubulin-

Contig9 from like GTP-binding protein and GTPase SEQ ID n° 10156 PL-2754.1 4885599 to 933 [Escherichia coli K12] gb|AAG54399. l|AE005186_5

4886759 (AE005186) cell division; forms circumferential ring; tubulin-like GTP-binding protein and GTPase [Escherichia coli

0157 :H7] SEQ ID n~2959

sp | PO 7652 | LPXC_ΞCOLI UDP-3 -O- [3 -

HYDROXYMYRISTOYL] N-ACΞTYLGLUCOSAMINE

DEACΞTYLASΞ (ΞNVA __ PROTΞIN) pir| |BVΞCΞA UDP-3-0- [3-hydroxymyristoyl] N- acetylglucosamine deacetylase (EC

3.5.1.-) - Ξscherichia coli emb]CAA38873.l|

(X55034T ËήvA^"pfotein [Escheπchia coli]

Contig9 from gb|AAA83849.l| (M19211) ell permeability-cell SEQ ID n° 10157 PL-2753.1 4886843 to 933 séparation protein [Escherichia coli]

4887775 dbj |BAA01361.l| (D10483) envA protein

[Escheπ7hia^""colï] gb] AAC73207.l| (AΞO00119)

UDP-3-O-acyl N-acetylglucosamine deacetylase; lipid A biosynthesis [Ξscherichia

COli K12] gb|AAG54400.l]AE005186_6 (AE005186)

UDP-3-O-acyl N-acetylglucosamine deacetylase; lipid A biosynthesis [Escherichia coli 0157 :H7] SΞQ ID n~2958 pir| |G82080 hypothetical protein VC2395

Contig9 from

[imported] - Vibrio cholerae (group 01

SEQ ID n° 10158 PL-2752.1 4887903 to 39%

Strain N16961) gb|AAF95538.l| (AE004310)

4888430 hypothetical protein [Vibrio cholerae] SΞQ ID n~2957

Contig9 from gb|AAG54401.l(AE005186_7 (AE005186) orf,

SEQ ID n° 10159 PL-3506.1 4888529 to 57% hypothetical protein [Escherichia coli 0157 :H7]

4888987 SΞQ ID n~2721

Contig9 from gb|AAG54402.l|AΞ005186_8 (AΞ005186) preprotein

SEQ ID n° 10160 PL-2751.1 4889071 to 93% translocase; secretion protein [Ξscherichia

4891782 coli 0157 :H7] SΞQ ID n~2956 gb|AAG54403.l|AE005186_9 (AE005186) 7,8-dihydro-

Contig9 from

8-oxoguanine-triphosphatase, prefers dGTP,

SEQ ID n° 10161 PL-5693.1 4891903 to 69% causes AT-GC transversions [Escherichia coli

4892295

0157:H7] #N/A pir| |E64732 yacG protein - Escherichia coli

Contig9 from (strain K-12) gb | AAC73212.1 | (AΞ000119) orf, SΞQ ID n° 10162 PL-5691.1 4892334 to 763 hypothetical protein [Escherichia coli K12]

4892531 gb|AAG54405.l|AΞ005186_ll (AΞ005186) orf, hypothetical protein [Ξscherichia coli 0157 :H7] #N/A

sp|P36680|YACF_ECOLI HYPOTHΞTICAL 28.3 KD

C -SEQ—I-D-n°-10163 PL-2750.1

Contig9 from - Escherichia coli (strain K-12) gb|AAC73214.1 | SEQ ID n° 10164 PL-2749.1 4893307 to 643 (AE000119) putative DNA repair protein

4893930 [Escherichia coli K12] gb|AAG54407.l|AE005186_13 (AΞ005186) putative

DNA repair protein [Ξscherichia coli 0157.-H7] SEQ ID n~2953 gb|AAG54410.l|AΞ005187_3 (AE005187) putative

Contig9 from intégral membrane protein involved in SEQ ID n° 10165 PL-2748.1 4894022 to 51% biogenesis of fimbriae, protein transport, DNA

4895221 uptake [Ξscherichia coli 0157 :H7] SEQ ID n~2952 gb|AAG54411.l|AΞ005187_4 (AE005187) putative

Conti g9 from intégral membrane protein involved in SEQ ID n° 10166 PL-2747.1 48S5224 to 593 biogenesis of fimbriae, protein transport, DNA

4896656 uptake [Escherichia coli 0157 :H7] SEQ ID n~2951

Contig9 from emb|CAB89833.l| (AJ242516) PpdD protein SEQ ID n° 10167 PL-3505.1 4896834 to 54% [Salmonella typhimurium]

4897256 SEQ ID n~2720 Contig9 from emb|CAB89834.l| (AJ242516) NadC protein SΞQ ID n° 10168 PL-2746.1 4897454 to 77% [Salmonella typhimurium]

4898344 SEQ ID n~2950 Contig9 from gb|AAG54415.l[AΞ005187_8 (AE005187) régulâtes SEQ ID n° 10169 PL-2745.1 4898840 to 69% ampC [Escherichia coli 0157 :H7]

4899694 SEQ ID n~2949 Contig9 from SEQ ID n° 10170 PL-5690.1 4899821 to m No Hits found

4900021 #N/A

SΞQ ID n° 10

fimbriae, interrupted [Ξscherichia coli K12] SΞQ ID n~2948

Contig9 from

SΞQ ID n° 10172 PL-5688.1 4901332 to m No Hits found

4901469 #N/A

Contig9 from

SΞQ ID n° 10173 PL-5687.1 4901580 to m No Hits found

4901795 #N/A

Co

SΞQ ID n° 10174 PL-2743.1 4

Contig9 from

SΞQ ID n° 10175 PL-5686.1 4902625 to m No Hits found

4902819 #N/A

Contig9 from

SΞQ ID n° 10176 PL-5685.1 4902852 to m No Hits found

4903238 #N/A

Contig9 from

SΞQ ID n° 10177 PL-5684.1 4903551 to m No Hits found

4903694 #N/A pir| |F82969 hypothetical protein PA5402

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 10178 PL-3504.1 4904213 to 533 (strain PAOl) gb | AAG08787.1 | Ξ004953_1

4904791 (AΞ004953) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~2719

pir| |G82969 probable transcription regulator

PA5403 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) -SΞQ ID n° 10179 PL-5681.1 4904800— o— -71% gb]AAG08788.l|AΞ004953_2 (AΞ004953) probable

4905021 transcriptional regulator [Pseudomonas

aeruginosa] #N/A

ContigS ^"from

SΞQ ID n° 10180 PL-7349.1 4905291 to No Hits found

4905638 #N/A

Contig9 from

SΞQ ID n° 10181 PL-5679.1 4905740 to No Hits found

4906054 #N/A

Contig9 from emb|CAB89840.l[ (AJ242516) PdhR protein

SΞQ ID n° 10182 PL-2742.1 4906786 to 87% [Salmonella typhimurium] 4907550 SEQ ID n-2946 sp|P06958|θDPl_ΞCOLI PYRUVATΞ DΞHYDROGENASΞ Ξl

COMPONΞNT pir| |DEΞCPV pyruvate dehydrogenase

(lipoamide) (EC 1.2.4.1) - Escherichia coli

Contig9 from gb|AAC73225.l| (AE000120) pyruvate dehydrogenase

SΞQ ID n° 10183 PL-2741.1 4907740 to 933 (decarboxylase component)

4910403 [Escherichia coli K12] gb|AAG54418.l|AΞ005187_ll (AΞ005187) pyruvate dehydrogenase (decarboxylase component)

[Escherichia coli θl57:H7] SEQ ID n~2945

sp [ PO6959 | ODP2_ECOLI DIHYDROLIPOAMIDE ACΞTYLTRANSFERASΞ COMPONΞNT OF PYRUVATE DEHYDROGENASΞ COMPLΞX (Ξ2) pir] |XXECDP dihydrolipoamide S-acetyltransferase (EC

2.3.1.12) aceF [validated]

Contig9 from _ Escherichia coli emb | CAA24741.11 (V01498) aceF

SEQ ID n° 10184 PL-2740.1 4910418 to 85% [Escherichia coli] dbj |BAA05573.l| (D26562)

4912016 'dihydrolipoamide acetyltransferase (Ξ2 component of pyruvate dehydrogenase complex)' [Ξscherichia coli] gb |AAC73226.1 |

(AEO00120) pyruvate dehydrogenase

(dihydrolipoyltransacetylase component) [Escherichia coli K12] SΞQ ID n~2944

Contig9 from emb|CAA24742. l| (V01498) coding séquence of gène SEQ ID n° 10185 PL-2738.1 4912220 to 95% lpd [Ξscherichia coli]

4913650 SΞQ ID n~2941 Contig9 from SEQ ID n° 10186 PL-5674.1 4913817 to No Hits found

4914047 #N/A sp|P36683|AC02_ΞCOLI ACONITATE HYDRATASΞ 2

Contig9 from (CITRATE HYDRO-LYASE 2) (ACONITASE 2) SEQ ID n° 10187 PL-2736.1 4914123 to 93% pir||F64734 aconitate hydratase (EC 4.2.1.3) 2

4916720 Escherichia coli gb|AAC73229.l| (AE000121) aconitate hydrase B [Ξscherichia coli K12] SEQ ID n~2939

Contig9 from gb]AAB81983.l| (AF025662) unknown [Vibrio SEQ ID n° 10188 PL-5672.1 4917754 to 35% cholerae]

4918020 #N/A Contig9 from

SEQ ID n° 10189 PL-5671.1 4918070 to No Hits found

4918300 #N/A pir| |G64734 yacL protein - Escherichia coli

Contig9 from gb|AAC73230.l| (AE000121) orf, hypothetical SEQ ID n° 10190 PL-5670.1 4918309 to 71% protein [Ξscherichia coli K12]

4918680 gb|AAG54423.l|AΞ005188_4 (AΞ005188) orf, hypothetical protein [Ξscherichia coli 0157 :H7] #N/A

sp| 052401 |YGGB_EDWIC HYPOTHETICAL 30.6 KDA

ContigS from

PROTEIN IN- ICIA-FBA INTERGENIC REGION SΞQ ID n° 10191 PL-2735.1 4918819 to 793 gb[AAB92571.l| (AF037440) putative 30.6 kDa 4-9-196-91 protein [Edwardsiella ictaluri] SEQ ID n~2938

Contig9 from

SEQ ID n° 10192 PL-3503.1 4920121 to m No Hits found

⁼ 492CHS51 SEQ ID n~271£ Contig9 from gb|AAG56271.l|AE005355_5 (AE005355) putative SEQ ID n° 10193 PL-2734.1 4920648 to 34% enzyme [Escherichia coli 0157 :H7]

4921946 SEQ ID n~2937 sp|P11667|YGGA_ECOLI HYPOTHΞTICAL 23.2 KD

PROTΞIN IN SBM-FBA INTΞRGΞNIC RΞGION (ORF 5) p r] |QQΞC5A hypothetical 23K protein (sbm-fba

Contig9 from intergenic région) - Ξscherichia coli SEQ ID n° 10194 PL-2733.1 4922864 to 683 gb|AAA69090.l| (U28377) 0RF_f211; alternate name

4923487 yggA,- orf5 of X14 36 [Escherichia coli] gb|AAC75960.l| (AE000375) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~2936 sp|P11668|YGGE_ECOLI HYPOTHETICAL 26.6 KD

PROTEIN IN SBM-FBA INTERGΞNIC RΞGION (ORF 6)

(F246) pir| |A65077 hypothetical 26.6K protein

(sbm-fba intergenic région) -

Contig9 from

Ξscherichia coli gb| AAA69089. l| (U28377) SEQ ID n° 10195 PL-2732.1 4923601 to 683

ORF_f246; alternate name yggΞ'; orf6 of X14436

4924323

[Ξscherichia coli] gb| AAC75959.1 | (AΞ000375) putative actin [Escherichia coli K12] gb|AAG58048.l|AE005522_6 (AΞ005522) putative actin [Escherichia coli 0157 :H7] SEQ ID n~2935 sp] 052399 |ICIA_EDWIC CHROMOSOMΞ INITIATION

Contig9 from INHIBITOR (ORIC REPLICATION INHIBITOR) SEQ ID n° 10196 PL-2731.1 4924320 to 91% gb|AAB92569.l| (AF037440) inhibitor Of

4925222 chromosome initiation [Edwardsiella ictaluri] SEQ ID n~2934

Contig9 from SEQ ID n° 10197 PL-5669.1 4925320 to m No Hits found

4925514 #N/A

Contig9 from

SEQ ID n° 10198 PL-3502.1 4925603 to No Hits found

4926157_^ SEQ ID n~2717

Contig9 from

SEQ ID n° 10199 PL-5668.1 4

Co

SEQ ID n° 10200 PL-1262.1 4

sp | P08328 | SERA_ΞCOLI D-3-PHOSPHOGLYCΞRATΞ

DΞHYDROGΞNASΞ (PGDH) pir | | DΞΞCPG phosphoglycerate dehydrogenase (ΞC 1.1.1.95) -

Ξscherichia coli gb|AAA24625. l| (L29397) phosphoglycerate dehydrogenase [Escherichia

Contig9 from coli] gb|AAA69080.l| (U28377) D-3-

SEQ ID n° 10201 PL-1261.1 4927861 to 88% phosphoglycerate dehydrogenase [Escherichia

4929102 coli] gb|AAC75950.l| (AΞ000374) D-3- phosphoglycerate dehydrogenase [Escherichia coli

K12] gb|AAG58040.l|AE005521_8 (AE005521) D-3- phosphoglycerate dehydrogenase [Escherichia coli

0157 :H7] SEQ ID n~331

Contig9 from gb|AAG58038.l|AE005521_6 (AE005521) putative SEQ ID n° 10202 PL-5667.2 4929151 to m 773 ligase [Ξscherichia coli 0157 :H7 ΞDL933]

4929366 #N/A

sp | PO9160 ] YGFA_ΞCOLI HYPOTHΞTICAL 21.1 KDA

PROTΞIN IN SSR-SΞRA INTΞRGΞNIC REGION (0182) pir| |QQEC2K hypothetical 21. IK protein (ssr-serA intergenic région) Escherichia coli gb|AAA24651.l| (M12965) 22-kDa protein

Contig9 from

[Escherichia coli] gb|AAA69079.l| (U28377)

SEQ ID n° 10203-PL--5666.-2- - 4929382 to m 503

^"0^"RF_oî82; two upstream start codons, one within 4929795 ssr [Escherichia coli] gb|AAC75949.l| (AE000374) putative ligase

[Ξscherichia coli K12] dbj [BAB37205.l|

^~ (AP002563) putative ligase [Escherichia^~~cόli^~

0157 :H7] #N/A sp|P45580 |YGFE_ECOLI HYPOTHΞTICAL 12.6 KD

PROTΞIN IN PEPP-SSR INTERGENIC REGION (O109) pir| |F65075 hypothetical 12.7 kD protein in pepP ssr intergenic région - Escherichia

Contig9 from coli (strain K-12) gb|AAA6S078. l| (U28377)

SΞQ ID n° 10204 PL-5665.1 4930082 to m 763

ORF_ol0S [Escherichia coli] gb | AAC75348.1 |

4930411

(AΞ000374) orf, hypothetical protein

[Escherichia coli K12] gb]AAG58037.l| AΞ005521_5

(AE005521) orf, hypothetical protein

[Bscherichia coli 0157 :H7] #N/A sp | P25533 | YGFB_ECOLI HYPOTHETICAL 21.5 KD

PROTEIN IN PΞPP-SSR INTERGENIC RΞGION (0RF1S4)

(F134) pir| |A47020 hypothetical 21.5K protein

(pepP-ssr intergenic région) -

Contig9 from Escherichia coli dbj |BAA14324.1 | (DS0281) SΞQ ID n° 10205 PL-3501.1 4930601 to 703 ORF1S4 protein [Escherichia coli]

4931176 gb|AAA63077.l| (U28377) ORF_fl34 [Escherichia coli] gb|AAC75947.l| (AE000374) orf, hypothetical protein [Escherichia coli K12] gb|AAG58036.l|AE005521_4 (AΞ005521) orf , hypothetical protein [Ξscherichia coli 0157.-H7] SEQ ID n~2716

Contig9 from gb|AAG58035.l|AΞ005521_3 (AΞ005521) proline SΞQ ID n° 10206 PL-1260.1 4931223 to 843 aminopeptidase P II [Escherichia coli 0157 :H7]

4932539 SEQ ID n~330

pir| |C65075 probable 2-octaprenyl-6- methoxyphenol 4 -monoxygenase (ΞC 1.14.13. - )

C SEQ ID n° 10207 PL- 1259 . 1

coli K12] SEQ ID n~S28

ContigS from gb|AAG58033.l|AE005521_l (AE005521) orf, SΞQ ID n° 10208 PL-1258.1 4933764 to 71% hypothetical— rotein - [Ξscherichia coli 0157 :H7]

^"4934984 SΞQ ID n~927 sp | P27248 | GCST_ECOLI AMINOMETHYLTRANSFERASE (GLYCINE CLEAVAGΞ SYSTEM T PROTEIN) pir] |A56689 aminomethyltransferase (ΞC 2.1.2.10) [validated]

- Escherichia coli gb|AAC36843.l| (M97 63) T-

Contig9 from protein [Escherichia coli] emb ] CAA52144.1 |

SΞQ ID n° 10209 PL-1257.1 4935343 to 79% (X73958) aminomethyltransferase [Escherichia

4936239 coli] gb]AAA69073.l| (U28377) ORF_f364

[Escherichia coli] gb|AAC75943.l| (AE000374) aminomethyltransferase (T protein; tetrahydrofolate-dependent) of glycine cleavage system [Ξscherichia coli K12] SΞQ ID n~S26 sp | P27248 | GCST_ECOLI AMINOMETHYLTRANSFERASE

(GLYCINE CLEAVAGE SYSTEM T PROTEIN) pir| |A56689 aminomethyltransferase (EC 2.1.2.10) [validated]

- Escherichia coli gb|AAC36843. l| (M97263) T-

Contig9 from protein [Escherichia coli] emb |CAA52144. l| SEQ ID n° 10210 PL-5662.1 4936154 to 71% (X73958) aminomethyltransferase [Escherichia

4936438 COli] gb|AAA69073.l| (U28377) ORF_f364

[Escherichia coli] gb| AAC75943.l| (AE000374) aminomethyltransferase (T protein; tetrahydrofolate-dependent) of glycine cleavage system [Escherichia coli K12] #N/A

sp|P23884|GCSH_ECOLI GLYCINE CLEAVAGE SYSTEM H

PROTEIN pir| |A56623 glycine cleavage system protein H - Ξscherichia coli gb]AAA68887.l|

(M57630) H-protein [Escherichia coli] emb|CAA5 145.l| (X73S58) H protem [Escherichia

coli] gb|AAA63072.l| (U28377) ORF f!29

- - - Contig9 from

[Ξscherichia coli] gb|AAC7594 .1 | (AE000374) in

SEQ ID n° 10211 PL-5661.1 4936560 to 81% glycine cleavage complex, carrier of aminomethyl

4936952 moiety via covalently bound lipoyl cofactor

[Escherichia coli K12] gb|AAG58031.l|AE005520_9 (AE005520) in glycine cleavage complex, carrier of aminomethyl moiety via covalently bound lipoyl cofactor

[Ξscherichia coli 0157 :H7] #N/A sp | P33195 | GCSP_ECOLI GLYCINE DEHYDROGENASE

[DECARBOXYLATING] (GLYCINE DECARBOXYLASΞ)

(GLYCINΞ CLΞAVAGΞ SYSTΞM P-PROTΞIN) pir||S36834 glycine dehydrogenase (decarboxylating) (ΞC

Contig9 from 1.4.4.2) - Ξscherichia coli SΞQ ID n° 10212 PL-1256.1 4937040 to 83% gb|AAA23867.l| (L20872) gcvHP [Escherichia coli]

4939916 emb|CAA52146.l| (X73958) glycine dehydrogenase

(decarboxylating) [Ξscherichia coli] gb|AAC75941.l| (AΞ000373) glycine decarboxylase,

P protein of glycine cleavage system

[Escherichia coli K12] SEQ ID n~325 pir] |E83641 probable hemagglutinin PA0041

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 10213 PL-1255.1 4940849 to 403 (strain PAOl) gb|AAG03431.l|AE004443_9

4947256 (AE004443) probable hemagglutinin [Pseudomonas aeruginosa] SEQ ID n~32

Contig9 from SEQ ID n° 10214 PL-1254.1 4947243 to No Hits found

4948136 SEQ ID n~323 Contig9 from SEQ ID n° 10215 PL-5658.1 4948136 to No Hits found

4948444 #N/A

sp|P3 394|YJIW ECOLI HYPOTHΞTICAL 14.6 KD

SΞQ ID n° 10216

[Ξscherichia coli K12] #N/A sp|085 64|RSR2_VIBCH CRYPTIC PHAGE CTXPHI

TRANSCRIPTIONAL REPRESSOR RSTR gb |AAC24223.1 | Contig9 from

(AF055890) repressor [Vibrio cholerae 569B]

SEQ ID n° 10217 PL-5655.1 4948832 to 42% gb|AAF29541.l|AF220606_l (AF220606) RstR [Vibrio

4949218 cholerae] gb|AAG38011.l|AF262318_2 (AF262318)

RstR classical [Vibrio phage CTX] #N/A

Contig9 from dbj |BAB05094.1] (AP001511) DNA primase [Bacillus SEQ ID n° 10218 PL-1253.1 4949320 to 163 halodurans]

4952634 SEQ ID n~322 pir| |F83177 integrase/recombinase XerD PA3738

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 10219 PL-1252.1 4952621 to 37% (strain PAOl) gb] AG07125.l| AE004793_2

4953751 (AE004793) integrase/recombinase XerD

[Pseudomonas aeruginosa] SΞQ ID n~321

Contig9 from SEQ ID n° 10220 PL-5651.2 4953945 to No Hits found

4954076 #N/A Contig9 from SEQ ID n° 10221 PL-7345.1 4954106 to m No Hits found

4954189 #N/A Contig9 from pdb|lF3l]A Chain A, Crystal Structure Of Tn5 SEQ ID n° 10222 PL-7344.1 4954283 to 57% Transposase Complexed With Transposon

4955665 Ξnd Dna #N/A Contig9 from SEQ ID n° 10223 PL-5647.2 4955676 to m No Hits found

4956071 #N/A

pir||C83339 hypothetical protein PA2462

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 10224 PL-2218.3 4955987 to 353 (strain PAOl) gb] AG05850.l| AE004673 10

4958773 (AE004673) hypothetical protein [Pseudomonas aeruginosa] #N/A

Contig9 from ^"SËQ ID n° 10225 PL-5644.1 4958791 tcT^ p ^" No Hits found

4958994 #N/A Contig9 from gb|AAF62314.l| (AΞ002420) MafB-related protein SΞQ ID n° 10226 PL-2219.1 4959381 to 28% [Neisseria—meningitidis MC58]

4959S5^"9 SEQ ID n~2377 pir| |H81173 hypothetical protein NMB0654

Contig9 from [imported] - Neisseria meningitidis SΞQ ID n° 10227 PL-5643.1 4959969 to 503 (group B strain MD58) gb | AAF41074. l| (AE002420)

4960286 hypothetical protein [Neisseria meningitidis

MC58] #N/A

ContigS from. emb|CAB72079.l| (AJ391284) hypothetical protein

SΞQ ID n° 10228 PL-2220.1 4960349 to 21% [Neisseria meningitidis]

4961581 SΞQ ID n~2379

Contig9 from

SΞQ ID n° 10229 PL-3496.1 4961653 to No Hits found

4962042 SEQ ID n~2712

Contig9 from

SΞQ ID n° 10230 PL-5642.1 4962113 to p No Hits found

4962391 #N/A

Contig9 from

SΞQ ID n° 10231 PL-5641.1 4962427 to No Hits found

4962576 #N/A

Contig9 from

SΞQ ID n° 10232 PL-563S.1 4964042 to No Hits found

4964206 #N/A

Contig9 from gb|AAC31980.l| (L39897) HecB [Pectobacterium

SEQ ID n° 10233 PL-2221.1 4964340 to 603 chrysanthemi]

4966019 SEQ ID n-2380

Contig9 from emb |CAB39044. l| (AL034559) HesB-like domain SEQ ID n° 10234 PL-2222.1 4966883 to m 17% protein [Plasmodium falciparum] 4967524 _SΞQ ID n~2381

Contig9 from dbj |BAB06239.l| (AP001515) transposase related SEQ ID n° 10235 PL-2223.1 4967521 to 21%

protein (20) [Bacillus halodurans]

4968546 SΞQ ID n~2382 pir| |S30159 N-formimidoyl fortimicin A synthase

Contig9 from Micromonospora olivasterospora SΞQ ID n° 10236 PL-2224.1 4970413 to p 61% dbj |BAA00940.l| (D10050) formimidoyl fortimicin

4971846 A synthetase [Micromonospora olivasterospora] SΞQ ID n-2383

Contig9 from emb|CAB94532.l| (AL359152) putative methylase SΞQ ID n° 10237 PL-2225.1 4971843 to p 41% [Streptomyces coelicolor A3 (2)]

4972694 SΞQ ID n~2384 pir| |F75017 probable glycine C-acetyltransferase (BC 2.3.1.29) PAB1244 - Pyrococcus

Contig9 from abyssi (strain Orsay) emb|CAB50580 l| SΞQ ID n° 10238 PL-2226.1 4972719 to p 41%

(AJ248288) 5-AMINOLΞVULINIC ACID SYNTHASE (8

4973993

AMINO-7-OXONΞNANOATΞ SYNTHASΞ)

[Pyrococcus abyssi] SEQ ID n~2385

Contig9 from gb|AAC44868.l| (U60417) PapB [Streptomyces SΞQ ID n° 10239 PL-5635.1 4974037 to p 36% pristinaespiralis]

4974396 #N/A Contig9 from gb|AAC44866.l| (U60417) PapA [Streptomyces SΞQ ID n° 10240 PL-2227.1 4974434 to p 58% pristinaespiralis]

4976452 SEQ ID n~2386 Contig9 from gb|AAC44867.l| (U60417) PapC [Streptomyces SΞQ ID n° 10241 PL-2228.1 4976445 to p 40% pristinaespiralis]

4977332 SEQ ID n-2.387

Contig9 from gb| AAC43550. l| (U40487) proton antiporter efflux SΞQ ID n° 10242 PL-2229.1 4977354 to p 63% pump [Mycobacterium smegmatis] prf | | 2207392A

4978886 efflux pump [Mycobacterium smegmatis] SEQ ID n~2388 pir| |E70806 hypothetical glycine-rich protein

Contig9 from

Rv3507 - Mycobacterium tuberculosis SΞQ ID n° 10243 PL-2230.1 4979482 to p 22%

(strain H37RV) emb | CAA17744.1 | (AL022022)

4980777

PE_PGRS [Mycobacterium tuberculosis] SΞQ ID n~£390

Contig9 from SEQ ID n° 10244 PL-5631.1 4980941 to No Hits found

4981039 #N/A pir| |H70846 hypothetical glycine-rich protein

Contig9 from

Rv3345c - Mycobacterium tuberculosis

SEQ ID n° 10245 PL-2231.1 4981457 to 243

(strain H37RV) emb|CAA17117.l| (AL021841) =4-98-2-76-1—

PE_P^"GRS [Mycobacterium tuberculosis] SEQ ID n~2391 pir||E75485 hypothetical protein - Deinococcus

Contig9 from radiodurans (strain RI) SEQ ID n° 10246 PL-2232.1 4983693 to m 483 gb|AAF10288.l]AΞ001927_7 (AΞ001327) hypothetical 4984298

^"protein [Deinococcus radiodurans] SEQ ID n~2392 sp|P39179|UP14__ECOLI UNKNOWN PROTΞIN FROM 2D-

PAGE (SPOT PR51) pir | |B65074 hypothetical

Contig9 from protein b28S8 - Escherichia coli (strain K-12) SEQ ID n° 10247 PL-2233.1 4984310 to m 79% gb|AAA83073.l| (U28375) ORF_o326 [Escherichia

4985299 coli] gb|AAC75936.l] (AΞ000373) orf, hypothetical protein [Escherichia coli K12] SEQ ID n~2393 sp|Q46825|YGFY_ECOLI HYPOTHΞTICAL 10.5 KD

PROTΞIN IN FLDB-BGLA INTΞRGΞNIC REGION pir| |A65074 hypothetical protein b2897 -

ContigS from Escherichia coli (strain K-12) gb |AAA83078. l| SEQ ID n° 10248 PL-5629.1 4985471 to 843 (U28375) ORF_f88 [Escherichia coli]

4985743 gb|AAC75935.l] (AΞ000373) orf, hypothetical protein [Escherichia coli K12] gb|AAG58025.l|AE005520_3 (AΞ005520) orf, hypothetical protein [Ξscherichia coli 0157 :H7] m/A

Contig9 from SEQ ID n° 10249 PL-5628.1

C SΞQ ID n° 10250 PL-3490.1

0157:H7] SEQ ID n~2706

ContigS from gb[AAB87499.l| (AF033437) site-specific SEQ ID n° 10251 PL-2234.1 4986788 to p 86% recombinase [Proteus mirabilis]

43876S9 SEQ ID n~23S4 sp|P39691|DSBC_ERWCH THIOL:DISULFIDE INTERCHANGE

Contig9 from PROTEIN DSBC PRΞCURSOR pir] | S44444 protein

SEQ ID n° 10252 PL-2235.1 4987723 to 66% disulfide-isomerase (ΞC 5.3.4.1) dsbC precursor

4988430 Erwinia chrysanthemi emb] CAÂ54108. l|

(X76687) dsbC [Ξrwinia chrysanthemi] SEQ ID n-2395

Contig9 from gb|AAG58020.l|AE005519_6 (AΞ005519) SSDNA SEQ ID n° 10253 PL-2236.1 4988430 to 83% exonuclease, 5' --> 3' spécifie [Escherichia 4990163 coli 0157 :H7] SEQ ID n~ï396 sp|P07012|RF2_ECOLI PEPTIDE CHAIN RELEASE FACTOR

2 (RF-2) pir| |FCECR2 translation releasing

Contig9 from factor RF-2 - Ξscherichia coli (strain K-12) SΞQ ID n° 10254 PL-2237.1 4990385 to 94% gb| AAC75929.1 | (AE000372) peptide chain release

4991419 factor RF-2 [Ξscherichia coli K12] prf | |l806195A peptide chain-releasing factor: ISOTYPΞ=2 [Ξscherichia coli] SEQ ID n~23S7

Contig9 from pdb|lBBU|A Chain A, Lysyl-Trna Synthetase (Lyss) SEQ ID n° 10255 PL-2238.1 4991429 to Complexed With Lysine pdb | IBB | A Chain A, Lysyl

4992943 Trna Synthetase (Lyss) SEQ ID n~2398 pir] |E82482 antibiotic acetyltransferase VCA0253

Contig9 from

[imported] - Vibrio cholerae (group SEQ ID n° 10256 PL-2239.1 4993419 to p 81%

01 Strain N16961) gb | AAF96164.1 | (AE004365)

4994042 antibiotic acetyltransferase [vibrio cholerae] SEQ ID n~233S ref |NP_073263. l| orf39 [Salmonella enterica

Contig9 from serovar Choleraesuis] dbj |BAB 0546. l| SΞQ ID n° 10257 PL-2240.1 4994246 to 733

(AB040415) orf39 [Salmonella enterica serovar

4995253

Choleraesuis] SEQ ID n-2.401

Contig9 from SΞQ ID n° 10258 PL-7340.1 4995859 to No Hits found

4995981 #N/A pir| |T35272 hypothetical protein SC5F2A.30 -

Contig9 from

Streptomyces coelicolor emb | CAB406S7.1 | SEQ ID n° 10259 PL-2241.1 4S96002 to m 403

(AL04S587) hypothetical protein [Streptomyces

4996769 coelicolor A3 (2) ] SEQ ID n~2402

pir A83414 probable transcription regulator

SEQ ID n° 10260-

SEQ ID n° 10261 PL-2243.1 4998062 to 71% OPERON REGULATORY PROTΞIN gb | AAC44813.1]

4999729 (U51873) PrpR [Salmonella typhimurium] SEQ ID n~2404 sp|Q56062 |CPPM_SALTY PUTATIVΞ CARBOXYVINYL-

CARBOXYPHOSPHONATB PHOSPHORYLMUTASΞ

Contig9 from

(CARBOXYPHOSPHONOBNOLPYRUVATΞ PHOSPHONOMUTASE) SΞQ ID n° 10262 PL-2244.1 5000062 to 86%

(CPEP PHOSPHONOMUTASE)

5000952 gb|AAC44814.l| (U51873) PrpB [Salmonella typhimuπum] SEQ ID n~2405 sp|P3166θ|CISZ_ECOLI METHYLCITRATE SYNTHASE

-(CITRATE SYNTHASE 2) pir|JE64760 citrate (si) - synthase (EC 4.1.3.7) - Escherichia coli

ContigS from gb|AAB18057.l| (U73857) similar to E. coli gltA

SEQ ID n° 10263 PL-2245.1 5001013 to 82% citrate synthase [Escherichia coli]

5002173 gb[AAC73436.l| (AΞ000140) putative citrate synthase; propionate metabolism?

[Escherichia coli K12] SEQ ID n~2406

Contig9 from sp|P74840|PRPD_SALTY PRPD PROTEIN

SEQ ID n° 10264 PL-2246.1 5002234 to gb]AAC44816.l| (U51873) PrpD [Salmonella

5003685 typhimurium] SEQ ID n~2407

Contig9 from gb|AAC44817.2| (U51879) PrpE [Salmonella

SΞQ ID n° 10265 PL-2248.1 5003758 to p 81% typhimurium]

5005644 SEQ ID n~240S

Contig9 from dbj |BAB04638.l] (AP001510) diaminobutyric acid

SΞQ ID n° 10266 PL-2243.1 5006797 to p 603 aminotransferase [Bacillus

5008107 halodurans] SEQ ID n~2410

Contig9 from dbj |BAB10550.l| (AB008265)

SEQ ID n° 10267 PL-2250.1 5008124 to 303 gene_id:MDC1 . -unknown protein [Arabidopsis

5008981 thaliana] SEQ ID n~2412

pir| |G83130 spermidine acetyltransferase PA4114

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 10268 PL-3489.1 5009000 to 463 (strain PAOl) gb [AAG07501.1 |AE004828 2

5009455 (AE004828) spermidine acetyltransferase

[Pseudomonas aeruginosa] SΞQ ID n~2704

pir| |τi4593 syringomycin synthetase -

ContigS from Pseudomonas ^" syringae pv. syringae SEQ ID n° 10269 PL-2251.1 5009515 to 533 gb|AAC80285.l| (AF047828) syringomycin

501S372 synthetase [Pseudomonas syringae pv. syringae] SΞQ ID n~2 13 pir | |T14593^~ syringomycin synthetase -

Contig9 from Pseudomonas syringae pv. syπngae SEQ ID n° 10270 PL-2252.1 5019372 to p 53% gb|AAC80285.1] (AF047828) syringomycin

5029184 synthetase [Pseudomonas syringae pv. syringae] SΞQ ID n~2414

Contig9 from gb|AAF17280.l| (AF204805) NosC [Nostoc sp . SEQ ID n° 10271 PL-2253.1 5023187 to p 52% GSV224]

5032588 SΞQ ID n~£415 Contig9 from gb|AAF17280.l| (AF204805) NosC [Nostoc sp . SEQ ID n° 10272 PL-2254.1 5032585 to p 52% GSV224]

5042400 SΞQ ID n~1416 Contig9 from gb|AAA48767.l[ (J03860) fatty acid synthase (ΞC SEQ ID n° 10273 PL-2255.1 5042436 to p 12% 3.2.1.23) [Gallus gallus]

5044274 SΞQ ID n~2417 Contig9 from gb|AAG57346.l|AE005453_3 (AE005453) putative ATP- SEQ ID n° 10274 PL-2256.1 5044315 to p 50% binding component of a transport System

5045991 [Escherichia coli 0157 :H7] SΞQ ID n~2418 gb|AAB50779.l| (S83325)

Contig9 from aspartyl (asparaginyl)beta-hydroxylase, HAAH SEQ ID n° 10275 PL-2257.1 5046095 to p 34% [human, hepatoblastoma cell line

5046883 HepG2, Peptide, 758 aa] [Homo sapiens] SEQ ID n~241S

Contig9 from emb|CAB92259.l| (AL356535) putative oxygenase SEQ ID n° 10276 PL-2258.1 5047071 to p 35% [Streptomyces coelicolor A3 (2)]

5048051 SEQ ID n~2420

pir| |H83348 probable acylase PA2385 [imported] -

Contig9 from Pseudomonas aeruginosa (strain PAOl)

SBQ ID n° 10277 PL-2259.1 5048054 to 443 gb|AAG05773.l|AE004664_10 (AE004664) probable 5050477 acylase [Pseudomonas aeruginosa] SEQ ID n~2421

Contig9 from

gb|AAF71807.l|AC013430_16 (AC013430) F3F9.18

SΞQ ID n° 10278 PL-2260.1 5050659 to 373 -— [Arabidopsis thaliana]-^—=

5051492 SEQ ID n-2423

Contig9 from

SΞQ ID n° 10279 PL-5618.1 5051686 to No Hits found

5051832 #N/A

Contig9 from

SEQ ID n° 10280 PL-5617.1 5051855 to m No Hits found

5052040 #N/A

Contig9 from

SEQ ID n° 10281 PL-2261.1 5052069 to No Hits found

5053034 SEQ ID n~2424

Contig9 from

SΞQ ID n° 10282 PL-5616.1 5053021 to No Hits found

5053248 #N/A pir| |C700S1 conserved hypothetical protein yydD

Contig9 from Bacillus subtilis dbj |BAA11278.1 | (D781S3) yydD SEQ ID n° 10283 PL-2151.2 5053239 to 38% [Bacillus subtilis] emb |CAB16057.1 | (Z99124)

5054969 similar to hypothetical proteins [Bacillus subtilis] SΞQ ID n~2303 pir| |B83170 hypothetical protein PA37S1

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 10284 PL-3488.1 5055466 to 36% (strain PAOl) gb |AAG07178.1 |AΞ004798_1

5055972 (AE004798) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2703 pir| |F83173 outer membrane protein OprC PA3790

[imported] - Pseudomonas aeruginosa

Contig9 from

(strain AOl) dbj |BAAO5664.I| (D2BH9) outer SEQ ID n» 10285 PL-2150.1 5056180 to 673 membrane protein C [Pseudomonas aeruginosa]

5058210 gb|AAG07177.l|AΞ004797_12 (AE004797) outer membrane protein OprC [Pseudomonas aeruginosa] SΞQ ID n-2302

Contig9 from emb| CAC14352.l| (AL445945) putative secreted SEQ ID n° 10286 PL-2143.1 5058258 to m 283 hydrolase [Streptomyces coelicolor]

5053052 SΞQ ID n~2300 pir] |Ξ83018 homocysteine synthase PA5025

ContigS from [imported] - Pseudomonas aeruginosa

SEQ ID n° 10287 PL-2148.1 5059665 to m (strain PAOl) gb| AAG08410. l| AB004915_5

5060939 (AE004915) homocysteine synthase [Pseudomonas aeruginosa] SΞQ ID n~2299 pir| |H82186 probable multidrug résistance protein NorM VC1540 [imported] - Contig9 from

Vïbrio choièrae (group 01 strain N16961)

SEQ ID n° 10288 PL-2147.1 5061621 to p 54% gb|AAF94694.l| (AE004232) multidrug résistance

5062382 protein NorM, putative [Vibrio cholerae] SEQ ID n~î298

Contig9 from gb|AAC44892.l| (U73112) hemoglobin-haptoglobin SEQ ID n° 10289 PL-2146.1 5063871 to p 20% utilization protein A [Neisseria

5064617 meningitidis] SEQ ID n~2297 Contig9 from gb|AAK03599.l| (AEO06188) unknown [Pasteurella SEQ ID n° 10290 PL-2145.1 5064700 to p 39% multocida]

5066199 SΞQ ID n~2296 pir| |C83035 hypothetical protein PA4897

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 10291 PL-2144.1 5066456 to p 25% (strain PAOl) gb| AAG08282.l| AE004902_10

5069500 (AE004902) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2295

Contig9 from gb|AAC83227.l| (AF070473) TonB [Pasteurella SΞQ ID n° 10292 PL-2143.1 5069583 to p 57% multocida] gb| AAK03272.1 | (AΞ006158) TonB

5070350 [Pasteurella multocida] SEQ ID n~2294 pir| |C83467 conserved hypothetical protein

Contig9 from PA1428 [imported] - Pseudomonas SΞQ ID n° 10293 PL-3487.1 5070417 to m 55% aeruginosa (strain PAOl)

5070878 gb|AAG04817.l|AE004572_5 (AE004572) conserved hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~2702

Co ^"""SEOnirn⁰ 10234 PL-2142.1 5

Co SΞQ ID n° 10295 PL-3486.1 5

Co

SEQ ID n° 10296 PL-5612.1 5074050 to m No Hits found

5074325 #N/A sp|P1342l|FMA_SΞRMA FIMBRIA A PROTBIN PRECURSOR

Contig9 from pir| |A31096 fimbrial protein precursor, mannose- SΞQ ID n° 10297 PL-5611.1 5074986 to 353 résistant - Serratia marcescens

5075390 (strain US46) gb|AAA26576.l| (M21161) SmfA protein [Serratia marcescens] #N/A

Contig9 from emb|CAA03Sll.l| (AJ000084) Ccml protein [Proteus

SEQ ID n° 10298 PL-2141.1 5076311 to 653 mirabilis]

5076796 SΞQ ID n~2292

Contig9 from emb|CAA03913.l| (AJ000084) putative acetyl

SΞQ ID n° 10299 PL-3483.1 5077006 to 70% transferase [Proteus mirabilis]

5077536 SEQ ID n~2700

Contig9 from

SΞQ ID n° 10300 PL-3482.1 5077616 to No Hits found

5078098 SΞQ ID n~2699

Contig9 from gb]AAG58469.l|AE005559_5 (AΞ005559) induced in

SEQ ID n° 10301 PL-2140.1 5078106 to 58% stationary phase, recognized by rpoS, affects

5078690 cell division [Ξscherichia coli 0157 :H7] SEQ ID n~2291

Contig9 from dbj |BAB03228.l| (AB046380) tail fiber protein

SEQ ID n° 10302 PL-5610.1 5079718 to 54% [Pseudomonas aeruginosa]

5080005 #N/A

Contig9 from dbj ]BAA35849.l| (D90742) Hypothetical 7.5 kd

SEQ ID n° 10303 PL-7296.1 5080231 to m 423 protein in mdoH-msyB intergenic

5080443 région. [Ξscherichia coli] #N/A

Contig9 from SEQ ID n° 10304 PL-3481.1 5080454 to m No Hits found

5080963 SEQ ID n~2698 pιr| |C83007 probable transcription regulator PA5116 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SEQ ID n° 103.05^PL-560-9.-l 5081038 to 46% gb|AAG08501.1|AE004324_6 ((AAEE000044932244)) probable

5081331 transcriptional regulator [Pseudomonas aeruginosa] #N/A ref |NP__043502.l| orf31 [Bacteriophage HPl]

Contig9 from sp|P51735|VPH_BPHPl PROBABLE TAIL FIBER PROTEIN SEQ ID n° 10306 PL-2133.1 5081754 to 433 (0RF31) pir||S63533 hypothetical protein 31 -

5083523 phage HPl gb|AAB09218.1 | (U24159) orf31

[Bacteriophage HPl] SΞQ ID n~2289

Contig9 from gb|AAG56009.l|AE005333_6 (AΞ005333) putative SEQ ID n° 10307 PL-2138.1 5083523 to 363 tail fiber protein of prophage CP-S33X

5084299 [Escherichia coli 0157 :H7] SΞQ ID n~2288 ref |NP_043504.l| orf33 [Bacteriophage HPl] sp|P51737|Y033_BPHPl HYPOTHΞTICAL 28.3 KD

Contig9 from

PROTΞIN IN LYS 3'REGION (ORF33) pir||S69541 SEQ ID n° 10308 PL-2137.1 5084262 to 423 hypothetical protein 33 - phage HPl

5084870 gb|AAB09220.l| (U2415S) orf33 [Bacteriophage

HPl] SΞQ ID n~2287 ref |NP_043505.l| orf34 [Bacteriophage HPl] sp | P51738 | Y034_BPHP1 HYPOTHETICAL 20.8 KD

Contigθ from

PROTEIN IN LYS 3 'REGION (ORF34) pir||S69542

SΞQ ID n° 10309 PL-3480.1 5084860 to 55% hypothetical protein 34 - phage HPl

5085378 gb|AAB09221.l| (U24159) orf34 [Bacteriophage

HPl] SΞQ ID n~2697 ref |NP_043506.l| orf35 [Bacteriophage HPl] sp|P51739|Y035_BPHPl HYPOTHBTICAL 58.7 KD

Contig9 from

PROTEIN IN LYS 3 ' RΞGION (ORF35) pir||S69543 SΞQ ID n° 10310 PL-2136.1 5085378 to 61% hypothetical protein 35 - phage HPl

5086877 gb|AAB09222.1] (U24159) orf35 [Bacteriophage

HPl] SEQ ID n~2286

Contig9 from SΞQ ID n° 10311 PL-5607.1 5086835 to No Hits found

5087026 #N/A

C SΞQ ID n° 10312 PL-5606.1

C

SEQ ID n° 10313 PL-3478.1 5087316 to 68% pir] |A64896 hypothetical protein bl438 -

5087783 Escherichia coli gb | AAC74520.1 | (AE000241) orf, hypothetical protein [Ξscherichia coli K12] SEQ ID n~2695 sp|P18837|SFSB_BC0LI SUGAR FΞRMΞNTATION

STIMULATION PROTΞIN B (NΞR-LIKΞ PROTEIN) pir| |BVΞCNP nlp protein - Ξscherichia coli emb[CAA48736.l| (X68873) Ner-like protein, homologous to Ner protein of bacteriophages Mu and D108 [Ξscherichia coli]

Contig9 from gb|AAA57989.l| (U18997) Ner-like protein

SEQ ID n° 10314 PL-5605.1 5088131 to m 52% [Ξscherichia coli] gb|AAC76220.l| (AΞ000399)

5088400 regulatory factor of maltose metabolism; similar to Ner repressor protein of phage Mu

[Ξscherichia coli K12] gb|AAG58322.l|AE005547_8 (AE005547) regulatory factor of maltose metabolism; similar to

Ner repressor protein of phage Mu [Ξscherichia coli 0157:H7] #N/A

Contig9 from

SΞQ ID n° 10315 PL-5604.1 5088397 to No Hits found

5088627 #N/A

Contig9 from

SEQ ID n° 10316 PL-5603.1 5088655 to No Hits found

5088906 #N/A

Contig9 from gb|AAG56452.l|AΞ005371_8 (AΞ005371) putative

SEQ ID n° 10317 L-2135.1 5089352 to m 47% integrase for prophage CP-933R [Ξscherichia

5090410 coli 0157 :H7] SEQ ID n~2285

Contig9 from SΞQ ID n° 10318 PL-5602.1 5090487 to No Hits found 5090702 #N/A

Contig9 from SEQ ID n° 10319 PL-5601.1 5

Contig9 from SΞQ ID n° 10320 PL-5600.1 5091142 to No Hits found

5091243 #N/A Contig9 from SEÇfTD n° 10321 PL-5599.1 5091447 to m ^"" No Hits fbùhd

5091635 #N/A pir| |T13296 hypothetical protein 8 -

Contig9 from

Streptococcus phage phi-O1205 gb] AAC79524.1 | SΞQ ID n° 10322 PL-3477.1 5091687 to 45%

(U88974) ORF8 [Streptococcus thermophilus

5092184 temperate bacteriophage O1205] SΞQ ID n~2694 pir| |T03004 exodeoxyribonuclease- III homolog -

Contig9 from

Salmonella typhimurium gb]AAC26062.l| SΞQ ID n° 10323 PL-2134.1 5092181 to m (AF001386) exodeoxyribonuclease VIII [Salmonella

5093341 typhimurium] SΞQ ID n~2284

Contig9 from

SΞQ ID n° 10324 PL-6939.1 5093955 to m No Hits found

5094113 #N/A

Contig9 from dbj |BAB06239.l| (AP001515) transposase related

SEQ ID n° 10325 PL-2133.1 5094120 to m 213 protein (20) [Bacillus halodurans]

5095145 SΞQ ID n~£283

Contig9 from

SΞQ ID n° 10326 PL-5595.1 5095321 to m No Hits found

5095665 #N/A

Contig9 from

SΞQ ID n° 10327 PL-5593.1 5095864 to No Hits found

5096169 #N/A

Contig9 from

SΞQ ID n° 10328 PL-5592.1 5096691 to No Hits found

5097062 #N/A

pir| |E82797 conserved hypothetical protein

Contig9 from XF0501 [imported] - Xylella SΞQ ID n° 10329 PL-5591.1 5097146 to 37% fastidiosa (strain 9a5c)

5097430 gb|AAF83311.l|AΞ003899_3 (AE003899) conserved hypothetical protein [Xylella fastidiosa]

Contig9 from gb|AAG57034.l|AE005422_9 (AE005422) unknown SEQ ID n° 10330 PL-5589TÏ 5097488 to 373 protein encoded within prophage CP-933U

5097937 [Escherichia coli 0157 :H7] #N/A Contig9 from SΞQ ID n° 10331 PL-5588.1 5097952 to No Hits found ^{" "~ "} 5098176 ^{" "} #N/A

Contig9 from pir| |T03010 probable réplication protein - SΞQ ID n° 10332 PL-2132.1 5098179 to 28% Salmonella typhimurium gb|AAC26071.l|

5098931 (AF001386) unknown [Salmonella typhimurium] SEQ ID n~£282 gb|AAA23700.l| (J04030) dnaC protein [Escherichia coli] gb| AAA97260. l| (U14003) CG

Site No. 849; alternate gène name dnaD

Contig9 from [Escherichia coli] gb | AAC77317.1 | SΞQ ID n° 10333 PL-3476.1 5098940 to 53% (AE000507) chromosome réplication,- initiation

5099524 and chain elongation [Escherichia

COli K12] gb|AAG59544.l|AE005667_8 (AΞ005667) chromosome réplication; initiation and chain elongation [Ξscherichia coli 0157 :H7] SΞQ ID n~26S3

Contig9 from ref |NP_037740.1| Gp55 [Bacteriophage HK97] SEQ ID n° 10334 PL-2131.1 5099526 to 60% gb|AAF3H33.l| (AF069529) Gp55 [Bacteriophage

5100893 HK97] SΞQ ID n~2281 Contig9 from SΞQ ID n° 10335 PL-3475.1 5101523 to No Hits found

5101990 SEQ ID n~2692 pir| |T36177 probable DNA-binding protein -

Contig9 from

Streptomyces coelicolor emb|CAB41077.l| SΞQ ID n° 10336 PL-2130.1 5102006 to P 36%

(AL049645) putative DNA-binding protein

5103205

[Streptomyces coelicolor A3 (2)] SEQ ID n~£280

Contig9 from gb|AAG56427.l|AΞ005369_16 (AE005369) unknown SEQ ID n° 10337 PL-3474.1 5103306 to 643 protein encoded within prophage CP-933R

5103899 [Escherichia coli 0157 :H7] SEQ ID n~2691

Contig9 from SEQ ID n° 10338 PL-5586.1 5103915 to No Hits found 5104175 #N/A

Contig9 from SEQ ID n° 10339 PL-5583.1 5 Co SΞQ ID n° 10340 PL-5582.1 5

Contig9 from gb|AAG56133.l|AE005344_9 (AE005344) unknown SΞQ ID n° 10341 PL-5581.1 5104895^"~to^"" 493 protein encoded by prophage CP-9330

5105095 [Ξscherichia coli 0157 :H7] #N/A Contig9 from gb|AAG56134.l|AΞ005344_10 (AΞ005344) putative SΞQ ID n° 10342 PL-3473.1 5105196 to 743 DNA adenine methyltransferase encoded by

5105669 prophage CP-9330 [Ξscherichia coli 0157 :H7] SEQ ID n~2630 sp|Q47588 |RDGB_BRWCA DNA-BINDING PROTBIN RDGB pir||S613S9 DNA-binding protein rdgB - Brwinia

Contig9 from carotovora subsp. carotovora gb | AAA24866.1 | SΞQ ID n° 10343 PL-5580.1 5105845 to m 59%

(L32173) DNA-binding protein [Pectobacterium

5106213 carotovorum] prf | |2105355B rdgB gène [Brwinia carotovora carotovora] #N/A ref |NP_050620.l] gpl6 [Bacteriophage Mu]

Contig9 from sp|Q38494|VG16_BPMU PROTBIN GP16 (E16 PROTEIN) SEQ ID n° 10344 PL-5579.1 5106197 to 53% gb|AAF01093.l]AF083977_12 (AF083977) gpl6

5106556

[Bacteriophage Mu] #N/A

Contig9 from SΞQ ID n° 10345 PL-5578.1 5106735 to m No Hits found

5106926 #N/A ContigS from SΞQ ID n° 10346 PL-2123.1 5107385 to 47% gb|AAC64124.l| (AF0S1717) Eha [Salmonella typhi]

5108473 SΞQ ID n-2278 pir| JC82157 hypothetical protein VC1739

Contig9 from

[imported] - Vibrio cholerae (group 01 SEQ ID n° 10347 PL-2128.1 5108796 to 523 strain N16961) gb | AAF94948. l| (AE004256)

5110580 hypothetical protein [Vibrio cholerae] SΞQ ID n~2277

pir| |H81132 hypothetical protein NMB1002

Contig9 from [imported] - Neisseria meningitidis SΞQ ID n° 10348 PL-2127.1 5110634 to 473 (group B strain MD58) gb |AAF41403.11 .CAΞ0_0_2451J__.

5111557 hypothetical protein [Neisseria meningitidis

pir| |F81890 hypothetical protein NMA1223

Contig9 from [imported] - Neisseria meningitidis SΞQ ID n° 10349 PL-5576.1 5111610 to m 43% (group A strain Z2491) emb| CAB84483.l|

5111918 (AL162755) hypothetical protein NMA1223

[Neisseria meningitidis Z2491] #N/A pir| |B81133 hypothetical protein NMB10Ô4

Contig9 from [imported] - Neisseria meningitidis SEQ ID n° 10350 PL-5575.1 5111974 to m 34% (group B strain MD58) gb| AAF41405.1 | (AE002451)

5112159 hypothetical protein [Neisseria meningitidis

MC58] #N/A

ContigS from gb]AAG56901.l|AE005412_ll (AE005412) unknown

SEQ ID n° 10351 PL-5574.1 5112245 to 483 protein encoded by prophage CP-933T [Ξscherichia

5112643 COli 0157 :H7] #N/A

ContigS from

SΞQ ID n° 10352 PL-5573.1 5112679 to p No Hits found

5113023 #N/A

Contig9 from

SEQ ID n° 10353 PL-5572.1 5113046 to p No Hits found

5113489 #N/A

Contig9 from

SEQ ID n° 10354 PL-3471.1 5113507 to p No Hits found

5113944 SΞQ ID n~2689

Contig9 from gb|AAG50260.l|AF311653_l (AF311653) probable DNA

SEQ ID n° 10355 PL-2126.1 5113992 to m 33% adenine methylase [Bacteriophage GMSE-1]

5114762 SEQ ID n-2275

Contig9 from

SEQ ID n° 10356 PL-5571.1 5115013 to p No Hits found

5115363 #N/A

sp|P44587|YFHD_HAΞIN HYPOTHETICAL PROTEIN HI0232

Contig9 from pir| |H64145 hypothetical protein HI0232 - SEQ ID n° 10357 PL-2125.1 5115396 to 263 Haemophilus influenzae (strain Rd

5115983 KW20) gb|AAC21901.l| (U32709) conserved hypothetical protein [Haemophilus influenzae Rd] SΞQ ID n~2274

Contig9 from SΞQ ID n° 10358 PL-2124.1 5115973 tO ^" No Hits found

5116596 SΞQ ID n-2273 Contig9 from SEQ ID n° 10359 PL-5570.1 5116593 to No Hits found

5116325 ^"#N/A Contig9 from SEQ ID n° 10360 PL-5563.1 5116318 to No Hits found

5117229 #N/A sp|P44223|YΞ99_HAΞIN HYPOTHETICAL PROTEIN HI149S pir| |H64032 hypothetical protein HI1499 -

Contig9 from

Haemophilus influenzae (strain Rd SΞQ ID n° 10361 PL-3470.1 5117229 to 50%

KW20) gb|AAC2314S.l| (U32826) H. influenzae

5117774 predicted coding région HI1499 [Haemophilus influenzae Rd] SEQ ID n~2688 ref |NP_050632.l| gp28 [Bacteriophage Mu]

Contig9 from sp|Q9TlW6]VG28_BPMU PROTΞIN GP28 SEQ ID n° 10362 PL-2123.1 5117771 to 56% gb|AAF01106.l|AF083977_25 (AF083977) gp28

5119234

[Bacteriophage Mu] SEQ ID n~2272 pir| |F81811 conserved hypothetical protein

NMA1851 [imported] - Neisseria

Contig9 from meningitidis (group A strain Z2491) SΞQ ID n° 10363 PL-2122.1 5119294 to 343 emb|CAB85074.l| (AL162757) conserved

5120787 hypothetical protein [Neisseria meningitidis

Z2491] SEQ ID n~2271 ref |NP_050634.l| gp30 [Bacteriophage Mu]

Contig9 from sp|Q01259|VPF_BPMU F PROTEIN (GPF) (PROTEIN SΞQ ID n° 10364 PL-2121.1 5120789 to 51%

GP30) gb|AAF01108.l|AF083977_27 (AF083977) gp30

5121598

[Bacteriophage Mu] SEQ ID n~2270

sp|P45255|VPG2_HA IN MU-LIKE PROPHAGE FLUMU G

Contig9 from PROTEIN 2 pir| ]B64130 hypothetical protein SΞQ ID n° 10365 PL-3469.1 5121591 to 383 HI1568 - Haemophilus influenzae (strain Rd

5122040 KW20) gbJAAC23215.l| {U3283lT^~G^""pToteïn7 (muG-2)

[Haemophilus influenzae Rd] SEQ ID n~2686

Contig9 from ^"SEQ ÎD n° 10366 PL-2120.1 5122245 to p No Hits found

5123339 SEQ ID n~2269 Contig9 from SEQ ID n° 10367 PL-2119.1 5123371 to No Hits found

5124306 SEQ ID n-2267 Contig9 from SΞQ ID n° 10368 PL-5566.1 5124320 to No Hits found

5124670 #N/A sp|P4423θ|VG36_HAEIN MU-LIKΞ PROPHAGΞ FLUMU

Contig9 from PROTΞIN GP36 pir| |F64033 hypothetical protein SEQ ID n° 10369 PL-3468.1 5124660 to 28% HI1508 - Haemophilus influenzae (strain Rd

5125109 KW20) gb|AAC23155.l| (U32827) conserved hypothetical protein [Haemophilus influenzae Rd] SEQ ID n~2685

Contig9 from SEQ ID n° 10370 PL-3467.1 512510S to No Hits found

5125576 SΞQ ID n~2684 Contig9 from SEQ ID n° 10371 PL-5565.1 5125573 to No Hits found

5125785 #N/A Contig9 from dbj |BAA7652l.l| (AB017338) tail sheath protein SEQ ID n° 10372 PL-2118.1 5125775 to [Pectobacterium carotovorum]

5127202 SBQ ID n~2266 Contig9 from dbj |BAA765 .l| (AB017338) tail core protein SΞQ ID n° 10373 PL-3466.1 5127202 to 93% [Pectobacterium carotovorum]

5127726 SΞQ ID n~2683 Contig9 from dbj |BAA96857.l| (AB045036) orf4 [Pectobacterium SΞQ ID n° 10374 PL-5563.1 5127984 to 693 carotovorum subsp. carotovorum]

5128310 #N/A

Contig9 from dbj |BAA96858.l| (AB045036) tail protein

SBQ ID n° 10375 PL-2117.1 5128393 to 54% [Pectobacterium carotovorum subsp.

SΞQ ID n° 10376

SΞQ ID n° 10377

Contig9 from dbj |BAA96861.l| (AB045036) tail spike

SΞQ ID n° 10378 PL-2114.1 5133207 to 75% [Pectobacterium carotovorum subsp.

5133812 carotovorum] SΞQ ID n~2262 dbj |BAA76524.l| (AB017338) baseplate

Contig9 from

[Pectobacterium carotovorum] dbj |BAA36862.1 |

SEQ ID n° 10379 PL-5559.1 5133850 to P 743

(AB045036) baseplate [Pectobacterium carotovorum

5134212 subsp . carotovorum] #N/A

Contig9 from dbj [BAAS6863.l| (AB045036) baseplate

SEQ ID n° 10380 PL-2113.1 5134203 to 78% [Pectobacterium carotovorum subsp .

5135306 carotovorum] SΞQ ID n~2261

Contig9 from dbj ]BAA76526.l| (AB017338) tail fiber

SEQ ID n° 10381 PL-2112.1 5135362 to 543 [Pectobacterium carotovorum]

5135874 SΞQ ID n~2260

Contig9 from dbj |BAA76527.2] (AB017338) tail fiber

SEQ ID n° 10382 PL-2111.1 5135834 to 253 [Pectobacterium carotovorum]

5136853 SΞQ ID n~ï25S ref |NP_047855.l| lambda tail fiber assembly protein G [Yersinia pestis] pir| |T14970 phage lambda-related tail assembly protein G -

Contig9 from

Yersinia pestis plasmid pMTl SEQ ID n° 10383 PL-5558.1 5136854 to p 46% gb|AAC82713.l| (AF074611) lambda tail fiber

5137306 assembly protein G [Yersinia pestis] emb|CAB55185.l| (AL117211) hypothetical protein

YPMT1.03C [Yersinia pestis] #N/A

sp|P18837|SFSB_ΞCOLI SUGAR FΞRMENTATION

STIMULATION PROTEIN B (NER-LIK PROTEIN) pir| |BVECNP nlp protein - Ξscherichia coli emb|CAA48736.l| (X68873) Ner-like protein, homologous to Ner protem of

bacteriophages Mu and D108 [Ξscherichia coli]

Contig9 from gb|AAA57389.l| (UÏ8997) Ner-like protein SEQ ID n° 10384 PL-5556.1 5137407 to 543 [Ξscherichia coli] gb| AAC76220.l| (AΞ0003S3)

5137694 regulatory factor of maltose metabolism; similar to Ner repressor protein of phage Mu

[EscherichiaTcori K12] gb|AAG58322.l]AΞ005547_8 (AE005547) regulatory factor of maltose metabolism; similar to

Ner repressor protein of phage Mu [Escherichia coli 0157.-H7] #N/A

Contig9 from SΞQ ID n° 10385 PL-5555.1 5137730 to No Hits found

5138023 #N/A Contig9 from SEQ ID n° 10386 PL-5554.1 5138112 to No Hits found

5138360 #N/A Contig9 from gb|AAG56134.l]AΞ005344_10 (AΞ005344) putative SΞQ ID n° 10387 PL-3465.1 5139176 to 77% DNA adenine methyltransferase encoded by

5139733 prophage CP-9330 [Escherichia coli 0157 :H7] SEQ ID n~2682 sp|P09162|YJAA_ECOLI HYPOTHETICAL 14.4 KD

PROTEIN IN RRFE-MΞTA INTΞRGΞNIC RΞGION (0127) pir| |Q3ECE4 hypothetical 14.4K protein (rrfΞ- metA intergenic région) - Ξscherichia

Contig9 from coli emb| CAA26569.l| (X02800) unidentified SEQ ID n° 10388 PL-3464.1 5139777 to 34% reading frame (pot. aa 1-127) [Escherichia

5140283 coli] gb]AAC43105.l| (U00006) alternate name yjaA [Escherichia coli] gb] AAC76981.l|

(AE000474) orf, hypothetical protein

[Escherichia coli K12] SEQ ID n~2681

ContigS from emb CAA09709.1 (AJ011581) gpl3 [bacteriophage SEQ ID n° 10389 PL-5552.1 5140339 to 59% PS119] 5140521 #N/A ref |NP_046950.l] gp54 [Bacteriophage N15] sp] 064362 |LYCV_BPN15 LYSOZYME (LYSIS PROTEIN)

Contig9 from

__ (MURAMIDASE) (ENDOLYSIN) (PROTEIN GP54) SΞQ ID n°-10-390-PL-2110.1 5140505 to 663 pir| ]T13141 lysozyme homolog - phage N15

5141041 gb|AAC19069.l| (AF064539) gp54 [Bacteriophage

N15] SEQ ID n~2258

Contig9 from sp|P7755l|RZPR_ECOLI PUTATIVE RZ ENDOPE-PTIDASΞ SΞQ ID^~n°^""lÔ391 PL-3463.1 5141134 to 41% FROM LAMBDOID PROPHAGΞ RAC

5141583 SEQ ID n~2680 Contig9 from SEQ ID n° 10332 PL-3462.1 5141714 to No Hits found

5142232 SEQ ID n~2679 Contig9 from SΞQ ID n° 10393 PL-2109.1 5142252 to No Hits found

5143151 SΞQ ID n~2256 Contig9 from gb|AAG53986.l|AF327444_2 (AF327444) putative SΞQ ID n° 10394 PL-3461.1 5143594 to 773 transposase B [Erwinia herbicola]

5143989 SΞQ ID n~2678 Contig9 from gb|AAG53985.1 | AF327444_1 (AF327444) putative SΞQ ID n° 10395 PL-5550.1 5143986 to 753 transposase A [Ξrwinia herbicola]

5144432 #N/A Contig9 from SEQ ID n° 10396 PL-5548.1 5144545 to No Hits found

5144862 #N/A Contig9 from

SEQ ID n° 10397 PL-2108.1 5144941 to No Hits found

5145660 #N/A sp|P44184|YE10_HAEIN HYPOTHETICAL PROTEIN HI1410 pir||E64028 hypothetical protein HI1410 -

ContigS from

Haemophilus influenzae (strain Rd SEQ ID n° 10398 PL-2107.1 5145720 to 253

KW20) gb|AAC23058.l| (U32820) H. influenzae

5146S25 predicted coding r gion HI1410 [Haemophilus influenzae Rd] SEQ ID n~2255

pir| |A82664 conserved hypothetical protein XF1571 XF1676 [imported] - Xylella

Contig9 from fastidiosa (strain Sa5c) SEQ ID n° 10399 PL-2106.1 5146903 to 28% gb|AAF8438Ô.l|ÂΞ003386_10 (AΞ003386) conserved ^"

gb|AAF84485.l|AE003S33_4 (AE003333) conserved hypothetical protein [Xylella fastidiosa] SEQ ID n~2254~ sp|P71385|YΞ07_HAΞIN HYPOTHETICAL PROTΞIN HI1407

Contig9 from pir] |B64122 hypothetical protein HI1407 - SEQ ID n° 10400 PL-2105.1 5148455 to 39% Haemophilus influenzae (strain Rd 5149186 KW20) -^"gb^"AAC23048.l| (U32820) traN-related ^" protein [Haemophilus influenzae Rd] SΞQ ID n~2253 pir||F82650 hypothetical protein XF1680 XF1575

[imported] - Xylella fastidiosa

Contig9 from

(strain 3a5c) gb] AAF8438 .1 | AE003386_14 SΞQ ID n° 10401 PL-2104.1 5149204 to 253

(AE003986) hypothetical protein [Xylella

5150529 fastidiosa] gb|AAF84489.l|AE003993_8 (AE003993) hypothetical protein [Xylella fastidiosa] SEQ ID n~2252

ContigS from SΞQ ID n° 10402 PL-3460.1 5150532 to No Hits found

5151008 SEQ ID n~2677 ContigS from SΞQ ID n° 10403 PL-2103.1 5151134 to No Hits found

5152042 SEQ ID n~2251 ContigS from SΞQ ID n° 10404 PL-5546.1 5152043 to No Hits found

5152369 #N/A Contig9 from SEQ ID n° 10405 PL-5545.1 5152374 to No Hits found

5152823 #N/A

pir ||C82651 hypothetical protein XF1685 XF1580

[imported] - Xylella fastidiosa ContigS from (strain 9a5c) gb| AF84389.1 | AE003986_19

SEQ ID n° 10406 PL-345S.1 5152823 to 29% (AE003986) hypothetical protein [Xylella

5153281 fastidiosa] gb |AAF84494.1 |AΞ003993_13

(AEO03993) hypothetical protein [Xylella fastidiosa] SEQ ID n~2675

ContigS from SEQ ID n° 10407 PL-5544.1 5153278 to No Hits found

5153649 #N/A Contig9 from SEQ ID n° 10408 PL-2102.1 5153610 to No Hits found

5154191 SEQ ID n~2250 pir ||F82651 hypothetical protein XF1688 XF1583

[imported] - Xylella fastidiosa

Contig9 from (strain 9a5c) gb| AAF84392.l| AE003986_22 SΞQ ID n° 10409 PL-2101.1 5154172 to 37% (AΞ003S86) hypothetical protein [Xylella

5155659 fastidiosa] gb | AAF84437.1 ] AΞ003393_16

(AΞ003993) hypothetical protein [Xylella fastidiosa] SEQ ID n~2249

Contig9 from SΞQ ID n° 10410 PL-3458.1 5155659 to No Hits found

5156036 SEQ ID n~2674 Contig9 from SEQ ID n° 10411 PL-5543.1 5156096 to No Hits found

5156503 #N/A pir| |T09486 hypothetical protein 47 - phage PI

Contig9 from gb|AAB88193.l| (AF035607) structural lytic SEQ ID n° 10412 PL-2100.1 5156709 to 19% transglycosylase [enterobacteria phage

5158829

PI] SEQ ID n~2248

Contig9 from SEQ ID n° 10413 PL-2099.1 5158829 to No Hits found

5159650 SEQ ID n~2245 Contig9 from SEQ ID n° 10414 PL-5541.1 5159647 to No Hits found

5159952 #N/A

Contιg9 from SEQ ID n° 10415 PL-2098.1 5159949 to p No Hits found _ 5160845 SΞQ ID n~2244

Contig9 from SEQ ID n° 10416 PL-3456.1 C

SEQ ID n° 10417 PL-3455.1 5161868 to No Hits found

5162401 SΞQ ID n~2671 Contig9 from SEQ ID n° 10418 PL-5539.1 5162558 to No Hits found

5162731 #N/A Contig9 from SEQ ID n° 10419 PL-5537.1 5162830 to No Hits found

5163186 #N/A pir| |A82649 hypothetical protein XF1704

ContigS from [imported] - Xylella fastidiosa SΞQ ID n° 10420 PL-2097.1 5163252 to 28% (strain 9a5c) gb|AAF84513.l|AE003334_12

5164427 (AE003994) hypothetical protein [Xylella fastidiosa] SEQ ID n~2243

Contig9 from SΞQ ID n° 10421 PL-2096.1 5164428 to No Hits found

5165033 SEQ ID n~£242 ref |NP_050653.l| S [Bacteriophage Mu]

Contig9 from sp | Q9T1V0 | VPS_BPMϋ TAIL FIBBR PROTΞIN (GPS) SΞQ ID n° 10422 PL-2095.1 5165020 to 19% gb|AAF01127.l|AF083977_46 (AF083977) S

5166363

[Bacteriophage Mu] SEQ ID n~22 1 ref |NP_047855.1 | lambda tail fiber assembly protein G [Yersinia pestis] pir] |T14970 phage lambda-related tail assembly protein G -

Contig9 from

Yersinia pestis plasmid pMTl SΞQ ID n° 10423 PL-5536.1 5166364 to 47% gb|AAC82713.l| (AF074611) lambda tail fiber

5166810 assembly protein G [Yersinia pestis] emb|CAB55l85.l| (ALH7211) hypothetical protein

YPMT1.03c [Yersinia pestis] #N/A

Contig9 from gb|AAG5S528.l|AΞ005665_10 (AE005665) orf; SΞQ ID n° 10424 PL-5535.1 5166358 to 32% hypothetical protein [Ξscherichia coli 0157 :H7]

5167242 #N/A

C SΞQ ID n° 10425 PL-5534.1

PROTΞIN B) pir| | S0701 small protein B, s pB -

Contig9 from Ξscherichia coli dbj |BAA02062.l| (D12501) small SΞQ ID n° 10426 PL-3454.1 5168451 to m 833 protein [Ξscherichia coli] gb] AAA79790.l|

5168933^{^} (U36840) smpB gène product [Escherichia coli] gb|AAC75669.l| (AE000347) small protein B

[Escherichia coli K12] SEQ ID n~2670

Contig9 from gb|AAG57729.l|AΞ005491_9 (AΞ005491) orf, SEQ ID n° 10427 PL-3453.1 5169090 to 803 hypothetical protein [Escherichia coli 0157 :H7]

5169524 SEQ ID n~2669 pir| |T08631 hypothetical protein b2618 -

Contig9 from Escheπchia coli (strain K-12) gb | AAA79788.11 SΞQ ID n° 10428 PL-5533.1 5169499 to 64% (U36840) ORF_fl02 [Escherichia coli]

5169810 gb]AAC75667.l| (AΞ000347) orf, hypothetical protein [Escherichia coli K12] #N/A sp|P23089|SMPA_ΞCOLI SMALL PROTEIN A PRECURSOR

ContigS from pir] |T08630 hypothetical protein ol33 - SΞQ ID n° 10429 PL-5532.1 5169866 to m 783 Escherichia coli gb|AAA79787.l| (U36840)

5170213 ORF_oll3 [Escherichia coli] dbj |BAA16502.1 |

(D90888) SMALL PROTEIN A. [Escherichia coli] #N/A pir| |RQΞCN recN protein - Ξscherichia coli

ContigS from gb|AAC75665.l| (AΞ000347) protein used in SΞQ ID n° 10430 PL-2034.1 5170452 to 80% recombination and DNA repair

5172113

[Ξscherichia coli K12] SEQ ID n~2240

sp|P37768|YFJB_ECOLI HYPOTHETICAL 32.6 KDA

C

SΞQ ID n° 10431 PL-20S3.1

coli] SEQ ID n~2239 sp|P09372|GRPE_ECOLI GRPE PROTEIN (HSP-70

COFACTOR) (HEAT SHOCK PROTEIN B25.3) (HSP24) pir|]S01240 heat shock protein grpΞ^""(heat shock protem b25.3) (hsp24) - Escherichia coli emb |CAA30711.1] (X07863) grpΞ protein (AA

Contig9 from 1-197) [Ξscherichia coli] gb|AAB32515.1 | SΞQ ID n° 10432 PL-2092.1 5173205 to p 683 GrpΞ≈heat shock protein [Ξscherichia coli,

5173786 mutant grpΞ25, Peptide Mutant, 197 aa] gb|AAC75663.l| (AE000347) phage lambda réplication; host DNA synthesis; heat shock protein; protein repair [Escherichia coli K12] dbj |BAA16498.l| (D90888) heat shock protein

B25.3 [Bscherichia coli] SEQ ID n~£238 pir| |C82086 uracil-DNA glycosylase VC2359

Contig9 from

[imported] - Vibrio cholerae (group SΞQ ID n° 10433 PL-2031.1 5173855 to m 81%

01 strain N16961) gb|AAF95502.l| (AΞ004306)

5174535 uracil-DNA glycosylase [ ibrio cholerae] SEQ ID n~2237

ContigS from gb[AAC3i479.l| (AF067849) phospholipase A SEQ ID n° 10434 PL-20S0.1 51752S4 to p 55% [Yersinia enterocolitica (type 0:8)]

5176310 SEQ ID n~2236 ContigS from gb(AAD29791.l| (U37262) accessory protein SEQ ID n° 10435 PL-3451.2 5176443 to p 61% [Serratia sp. MK1]

5176313 #N/A pir| |D71094 probable cofactor modifying protein

ContigS from Pyrococcus horikoshii dbj |BAA30114. l| SEQ ID n° 10436 PL-853.2 5177613 to p 33% (AP000004) 373aa long hypothetical cofactor

5178461 modifying protein [Pyrococcus horikoshii] SEQ ID n~3696

Contig9 from SEQ ID n° 10437 PL-854.1 5178463 to No Hits found 5179602 SEQ- ID_n=36-9-Z. SΞQ ID n° 10438 PL-855.1

SΞQ ID n° 10439 PL-3450.1 5180608 to p 59% DELTA-ISOMERASE (IPP ISOMERASE)

5181138 (ISOPENTENYL PYROPHOSPHATE ISOMERASE) SEQ ID n~2666 sp | P46377 [ FAS5_RHOFA HYPOTHETICAL 47.9 KD

OXIDOREDUCTASE IN FASCIATION LOCUS (ORF5)

Contig9 from pir||E55578 hypothetical protein (ipt 3' région) SEQ ID n° 10440 PL-856.1 5181335 to 17%

- Rhodococcus fascians plasmid

5182753 pFiD188 emb|CAA82745.l| (Z29635) orf5

[Rhodococcus fascians] SEQ ID n~3699

Contig9 from SΞQ ID n° 10441 PL-7330.1 5182927 to No Hits found

5183073 #N/A Contig9 from SΞQ ID n° 10442 PL-857.1 5183242 to No Hits found

5184351 SEQ ID n~3700 pir| |A72353 conserved hypothetical protein -

Contig9 from

Thermotoga maritima (strain MSB8) SEQ ID n° 10443 PL-858.1 5184373 to 44% gb | AD35669.1| EO01733_6 (AE001733) conserved

5184987 hypothetical protein [Thermotoga maritima] SEQ ID n~3701 sp|P71243 |WCAL_ECOLI PUTATIVE COLANIC ACID

BIOSYNTHESIS GLYCOSYL TRANSFERASΞ WCAL pir| |C64S70 hypothetical protein b2044 -

Contig9 from Escherichia coli (strain K-12) dbj |BAA15898 ,l| SΞQ ID n° 10444 PL-859.1 5185256 to 50% (D90842) ORF_ID:θ352#3; similar to [PIR

5186470 Accession Number S15296] [Ξscherichia coli] gb|AAC75105.l[ (AΞ000295) putative colanic acid biosynthesis glycosyl transferase

[Ξscherichia coli K12] SEQ ID n~3702

Contig9 from SEQ ID n° 10445 PL-860.1 5186477 to No Hits found 5187181 SEQ ID n~3704 pir||S39957 succinoglycan biosynthesis

Contig9 from glycosyltransferase (EC 2.4.1.-) exoM

SEQ ID n° 10446 PL-861.1 5187219 to 403 [validated] - Rhizobium meliloti

5188109 emb|CAA80346.l| (Z22636) ExoM [Sinorhizobium meliloti] SEQ ID n~3705 ref |NP_073225.l| ransposase of IS630 [Salmonella enterica serovar Choleraesuis] dbj |BAA01531.l[

Contig9 from

(D10689) M5 protein [Salmonella choleraesuis] SΞQ ID n° 10447 PL-862.1 5188485 to 723 dbj |BAB20556.l| (AB040415) ransposase of IS630

5189498

[Salmonella enterica serovar

Choleraesuis] SEQ ID n~3706

Contig9 from

SΞQ ID n° 10448 PL-3449.1 5189586 to No Hits found

5190095 SEQ ID n~2664

ContigS from

SΞQ ID n° 10449 PL-863.1 5190181 to No Hits found

5190927 SΞQ ID n~3707

Contig9 from gb|AAC95142.l| (AF075600) ABC translocator

SΞQ ID n° 10450 PL-864.1 5191056 to 40% [Brochothrix campestris]

5192150 SEQ ID n~3708

Contig9 from dbj |BAB06239.l| (AP001515) transposase related

SEQ ID n° 10451 PL-865.1 5192200 to 21% protein (20) [Bacillus halodurans]

5193225 SEQ ID n~3709

Contig9 from sp|P57552|MDLB_BUCAI MULTIDRUG RESISTANCE-LIRE

SEQ ID n° 10452 PL-3448.1 5193292 to 49% ATP-BINDING PROTEIN MDLB

5193819 SEQ ID n~2663

ContigS from gb[AAC61717.l| (AF081284) chromosomal hemolysin

SEQ ID n° 10453 PL-866.1 5193851 to 39% D [Escherichia coli]

5195026 SΞQ ID n~3710

Contig9 from

SEQ ID n° 10454 PL-3447.1 5195584 to No Hits found

5196102 SΞQ ID n~2662

sp|P21507|SRMB_ECOLI ATP-DΞPΞNDΞNT RNA HΞLICASΞ SRMB pir| |G65035 ATP-dependent RNA helicase

SrmB - Bscherichia coli emb| CAA32364.11

(X14152) SrmB protein [Escherichia coli]

ContigS from dbj |BAA02447.l| (D13169) putative ATP dépendent SEQ ID n° 10455 PL-867.1 5196273 to 743 RNA helicase [Escherichia coli] dbj |BAA10922.l| _: 5197610

(D64^"044) putative ATP dépendent RNA helicase [Escherichia coli] gb|AAC75629.l| (AΞ000344) ATP-dependent RNA helicase [Ξscherichia coli

K12] SEQ ID n~3711

Contig9 from gb |AAG57691. l |AE005488_2 (AE005488 ) putative

SEQ ID n° 10456 PL-868.1 5197893 to 633 enzyme [Escherichia coli 0157 :H7]

5198627 SEQ ID n~3712 pir| |0XECLD L-aspartate oxidase (ΞC 1.4.3.16)

Contig9 from nadB [validated] - Escherichia coli

SEQ ID n° 10457 PL-869.1 5198695 to m 853 gb|AAC75627.l| (AE000344) quinolinate

5200299 synthetase, B protein [Ξscherichia coli K12] SΞQ ID n~3713

Contig9 from dbj |BAA10920.l| (D64044) RNA polymerase sigma E

SEQ ID n° 10458 PL-3445.1 5200503 to 933 [Escherichia coli]

5201072 SEQ ID n~2660 sp|P38106]RSEA_ECOLI SIGMA-E FACTOR NEGATIVE REGULATORY PROTEIN pir | |B57255 sigma-E factor négative regulatory protein mclA - Escherichia

Contig9 from coli dbj |BAA10919.l| (D64044) MCLA protein SEQ ID n° 10459 PL-871.1 5201112 to 72% [Escherichia coli] gb] AAA83999.1 ] (U10148) MclA

5201762 [Escherichia coli] gb|AAC45315.l| (U37089) RseA

[Escherichia coli] gb | AAC75625.1 | (AΞ000343) sigma-Ξ factor, négative regulatory protein

[Ξscherichia coli K12] SEQ ID n~3715 pir| |T02998 sigma-Ξ factor regulatory protein

Contig9 from rseB - Salmonella typhimurium gb| AAC26064.1 | SEQ ID n° 10460 PL-872.1 5201768 to 66\

(AF001386) sigma-E factor regulatory protein

5202724

[Salmonella typhimurium] SΞQ ID n~3716

Contig9 from gb|AAG57686.l|AB005487_10 (AΞ005487) sigma-Ξ SEQ ID n° 10461 PL-3444.1 5202724 to 643 factor, négative regulatory protein [Escherichia

5203188 coli 0157 :H7] SΞQ ID n~2659

sp]P07682 JLEPA_ECOLI GTP-BINDING PROTEIN LEPA

SΞQ ID n° 10462 PL-873.1

protein [Escherichia coli 0157 :H7] SEQ ID n~3717

Contig9 from gb|AAG57684.l|AE005487_8 (AE005487) leader

SBQ ID n° 10463 PL-874.1 5205199 to 733 peptidase (signal peptidase I) [Escherichia coli

5206179 0157 :H7] SEQ ID n~3718 sp|P05797|RNC_ECOLI RIBONUCLEASE III (RNASE III) pir| |NREC3 ribonuclease III (EC 3.1.26.3) rnc -

Escherichia coli emb | CAA26692.1 | (X02946) ribonuclease III (rnc) (aa 1-226) [Escherichia

Contig9 from coli] dbj |BAA10914.l| (D64044) ribonuclease III

SEQ ID n° 10464 PL-875.1 5206354 to 95%

[Ξscherichia coli] gb] AAA79829. l| (U36841)

5207034

RNase III [Ξscherichia coli] gb|AAC75620.l|

(AE000343) RNase III, ds RNA [Escherichia coli

K12] gb|AAG57682.l|AE005487_6 (AΞ005487) RNase

III, ds RNA [Escherichia coli 0157 :H7] SEQ ID n~3719 sp|P06616|ERA_ΞCOLI GTP-BINDING PROTΞIN ΞRA pir| |S44713 GTP-binding protein era -

Ξscherichia coli pir||RGΞCGT GTP-binding protein era - Ξscherichia coli pdb|lEGA|B Chain

B, Crystal Structure Of A Widely Conserved

Gtpase Era pdb|lEGA[A Chain A, Crystal

ContigS from

Structure Of A Widely Conserved Gtpase Era

SΞQ ID n° 10465 PL-876.1 5207031 to 923 gb]AAA03242.l| (M14658) era [Escherichia coli]

5207939 dbj |BAA10913.l| (D64044) GTP binding protein

[Escherichia coli] gb | AAB34156. l| GTPase, Era

[Escherichia coli, Peptide Mutant, 301 aa] gb|AAA79828.l| (U36841) GTP-binding protein

[Escherichia coli] gb| AAC75619. l| (AΞ000343)

GTP-binding protein [Escherichia coli K12] SEQ ID n~3720

sp|P15027( ΞCO_ΞCOLI DNA REPAIR PROTEIN RECO

(RECOMBINATION PROTEIN O) pir| |BVECRO DNA repair protein recO - Escheπchia .αoli. gb[AAA24515.l[ (M27251) recombination protein

[Escherichia coli] gb| AAA21842. l| (M26416) recO

Contig9 from

[Escherichia coli] db |BAA10912.l| (D64044)

SE -I-D-n°—10466 PL-877.1 5207951 to -8-1%^- recO protein [Escherichia coli] gb|AAC75618.l|

5208676

(AE000343) protein interacts with RecR and possibly RecF proteins [Ξscherichia coli K12] gb|AAG57680.l|AΞ005487^4 (AΞ005487) protein interacts with RecR and possibly RecF proteins [Escherichia coli 0157 :H7] SEQ ID n~3721 sp|P24223|PDXJ_ECOLI PYRIDOXAL PHOSPHATE

BIOSYNTHETIC PROTEIN PDXJ pir| |A42293 pyridoxal phosphate biosynthetic protein pdxJ -

Contig9 from Escherichia coli gb| AAA24315. l| (M74526) pdxJ

SΞQ ID n° 10467 PL-878.1 5208871 to 823 [Escherichia coli] gb| AAA21845. l| (M76470) pdxJ

5209602 [Escherichia coli] gb |AAA79826. l| (U36841) CG

Site No. 416 [Escherichia coli] gb|AAC75617.l|

(AE000343) pyridoxine biosynthesis [Escherichia coli K12] SEQ ID n~3722 gb|AAG57678.l|AE005487_2 (AE005487) CθA:apo-

Contig9 from

[acyl-carrier-protein] SEQ ID n" 10468 PL-5523.1 5209602 to 733 pantetheinephosphotransferase [Escherichia coli

5209982

0157 :H7] #N/A

Contig9 from gb|AAG57676.l|AΞ005486_7 (AE005486) orf,

SΞQ ID n° 10469 PL-5522.1 5209985 to m 85% hypothetical protein [Ξscherichia coli 0157 :H7]

5210245 #N/A

Sp|P77699|TFAD_EC0LI TAIL FIBΞR ASSEMBLY PROTEIN

HOMOLOG FROM LAMBDOID PROPHAGE DLP12

Contig9 from pir| |G64788 ybcX protein, phage protein-related SΞQ ID n° 10470 PL-5521.1 5210713 to m 80% Escherichia coli gb| AAB40757. l| (U82598)

5210814 hypothetical protein [Escherichia coli] gb|AAC73662.l| (AΞO00161) orf, hypothetical protein [Ξscherichia coli K12] #N/A

Contig9 from gb|AAG5 576.l|AE005203_5 (AE005203) unknown SEQ ID n° 10471 PL-879.1 5210933 to 46% protein from prophage CP-933H [Escherichia coli 5211652 0157 :H7] -SEQ_ID__.n~3_7.23_ ref |NP_050998.l| P37 [Bacteriophage APSE-l]

Contig9 from sp | Q9T1R1 | TFA_BPAPS PROBABLB TAIL FIBBR ASSEMBLY

SEQ ID n° 10472 PL-5519.1 5212041 to m 62%

PROTEIN (P37) gb | AAF03980.1 | AF157835_37 5212475

(AF157835) P37 [Bacteriophage APSE-l] #N/A

Contig9 from gb|AAG54576.l|AΞ005203_5 (AΞ005203) unknown

SΞQ ID n° 10473 PL-880.1 5212477 to 403 protein from prophage CP-933H [Escherichia coli

5213304 0157 :H7] SΞQ ID n-3725

Contig9 from ^"gb|AAG54576.l|AE005203_5 (AE005203) unknown

SΞQ ID n° 10474 PL-881.1 5213877 to 323 protein from prophage CP-933H [Escherichia coli

5214704 0157 :H7] SEQ ID n~3726

Contig9 from pir| |G64887 probable tail fiber protein GP37 -

SΞQ ID n° 10475 PL-882.1 5215151 to m 16% Escherichia coli gb | AAC74454.1 | (AE000234)

5216422 putative membrane protein [Ξscherichia coli K12] SΞQ ID n~3727

Contig9 from gb|AAG54576.l|AE005203_5 (AΞ005203) unknown

SEQ ID n° 10476 PD-883.1 5216578 to m 42% protein from prophage CP-933H [Escherichia coli

5217297 0157 ;H7] SΞQ ID n~3728 sp|P09153|TFAE_ECOLI TAIL FIBER ASSEMBLY PROTEIN

ContigS from HOMOLOG FROM LAMBDOID PROPHAGE E14 pir| |A64861 SEQ ID n° 10477 PL-884.1 5218137 to 603 ycfA protein, phage protein-related -

5218736 Ξscherichia coli gb | AAC74240.1 ] (AE000214) orf, hypothetical protein [Escherichia coli K12] SΞQ ID n~3729

Contigs from pir| |S18687 Sc/SvN protein - Escherichia coli SEQ ID n° 10478 PL-3442.1 5218733 to 623 plasmid pl5B emb|CAA44050.l| (X62121) DNA

521S233 inversion product [Escherichia coli] SΞQ ID n~2658 Contig9 from gb|AAG54576.l|AE005203_5 (AE005203) unknown SEQ ID n° 10473 PL-5518.1 5213518 to m 323 protein from prophage CP-933H [Escherichia

5219919 coli 0157 :H7] #N/A pir| |C82199 RTX toxin RtxA VC1451 [imported] -

Contig9 from

Vibrio cholerae (group Ol strain SEQ ID n° 10480 PL-886.1 5221196 to 36%

N16961) gb|AAF94608.l| (AE004223) RTX toxin

5231791

RtxA [Vibrio cholerae] SΞQ ID n~3731

Contig9 from gb|AAG53986.l|AF327444_2 (AF327444) putative

SEQ ID n° 10481 PL-3439.1 5232245 to m 77% transposase B [Erwinia herbicola]

5232640 SEQ ID n~2655

Contig9 from gb|AAG53985.l|AF327444_l (AF327444) putative

SEQ ID n° 10482 PL-3438.1 5232637 to 75%

transposase A [Erwinia herbicola]

5233083 SEQ ID n~2654 sp|P30134| FHC_ΞCOLI HYPOTHΞTICAL 20.0 KD

PROTΞIN IN PURL-DPJ INTΞRGΞNIC REGION (ORF178) pir| |F65033 hypothetical 20.0 kD protein in purL dpj intergenic région - Escherichia coli (strain K-12) ^"emb^""| CAA51064. l| (X72336) orf

Contig9 from 178, gef-résistance, put. membrane protein SEQ ID n° 10483 PL-3437.1 5233961 to 74% [Escherichia coli] dbj | BAA10309.l| (D64044)

5234482 YFHC-ECOLI protein [Escherichia coli] gb|AAA79821.l| (U36841) alternate name yfhC; orfl78 of GenBank Accession Number

X72336 [Escherichia coli] gb|AAC75612.1]

(AE000342) putative deaminase [Escherichia coli

K12] SΞQ ID n~2653 pir||S56346 arginine decarboxylase (EC 4.1.1.19) adi, biodegradative - Escherichia

Contig9 from coli gb|AAA97017.l| (U14003) adi [Escherichia

SEQ ID n° 10484 PL-888.1 5234471 to 67% coli] gb| AAC77078.l| (AE000484) biodegradative

5236777 arginine decarboxylase [Escherichia coli

K12] SEQ ID n~3733

Contig9 from emb|CAA84588.l| (Z35428) ORF404 [Proteus SΞQ ID n° 10485 PL-889.1 5236908 to 66% mirabilis]

5238254 SEQ ID n~373

sp | P15254 | PURL_ΞCOLI

PHOSPHORIBOSYLFORMYLGLYCINAMIDINΞ SYNTHASΞ (FGAM

SYNTHASE) (FGAMS) (FORMYLGLYCINAMIDE

RIBOTIDE AMIDOTRANSFERASE) (FGARAT)

Contig9 from

(FORMYLGLYCINAMIDE RIBOTIDE SYNTHETASE)

SΞQ ID n° 10486 PL-890.1 5238581 to gb|AAA24456.l| (M19501) formylglycineamide

5242477 ribonucleotide synthetase (EC 6.3.5.3)

[Escherichia coli] gb| AAA79819. l| (U36841) phosphoribosylformylglycineamide synthetase

[Escherichia coli] SEQ ID n~3736 pir| |A83554 hypothetical protein^"PA072S

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 10487 PL-5511.1 5242594 to 44% (strain PAOl) gb | AAG04118.1 | AE004508_3

5242836 (AΞ004508) hypothetical protein [Pseudomonas aeruginosa] #N/A

Contig9 from emb|CAB62375.l| (AL117211) hypothetical protein SEQ ID n° 10488 PL-5510.1 5242928 to m 343 YPMT1.68A [Yersinia pestis]

5243200 #N/A Contig9 from SΞQ ID n° 10489 PL-5508.1 5243561 to No Hits found

5243848 #N/A Contig9 from gb|AAG57670.l|AΞ005486_l (AE005486) putative 2- SEQ ID n° 10490 PL-891.1 5243919 to 71% component sensor protein [Ξscherichia coli

5245415 0157 :H7] SEQ ID n~3737 Contig9 from gb|AAA73817.l| (U36841) alternate name yfhG; SEQ ID n° 10491 PL-892.1 5245509 to 433 orfl of GenBank Accession Number

5246264 S67014 [Ξscherichia coli] SΞQ ID n~3738

sp|P21712|YFHA_ECOLI HYPOTHETICAL 49.1 KDA

PROTEIN IN GLNB--PURL INTΞRGΞNIC REGION

(ORFXB) (ORF-2) pir| |A65033 hypothetical protein XB (glnB 5 ' région) - Escherichia coli

Contig9 from gb|AAC75607. l| (AE000341) putative 2-component

SEQ ID n° 10492 PL-893.1 5246261 to 92% transcriptional regulator

5247598 [Escherichia^"coli K12] dbj |BAA16462.l| (D90885) nitrogen regulator I homolog [Ξscherichia coli] gb|AAG57668.l|AE005485_6 (AE005485) putative 2- co ponent transcriptional regulator

[Escherichia coli 0157 :H7] SEQ ID n~3739 pir| |C82617 NH3 -dépendent NAD synthetase XF1961

Contig9 from [imported] - Xylella fastidiosa

SΞQ ID n° 10493 PL-894.1 5247665 to 623 (strain 9a5c) gb | AAF84763.l| AΞ004015_6

5249287 (AEO 04015) NH3 -dépendent NAD synthetase [Xylella fastidiosa] SEQ ID n~3740 sp|P05826|GLNB_BCOLI NITROGΞN RΞGULATORY PROTEIN P-II 1 pir| |RGΞCP2 nitrogen regulatory protein P-II.l - Ξscherichia coli pdb|2PIl| Pii, Glnb Product pdb | 1PIL | Signal Transducing Protein P2 (Product Of Glnb) emb | CAA41683.1 | (X58872) P'

Contig9 from II protein [Escherichia coli] gb| AAB28779.l| SΞQ ID n° 104S4 PL-5505.1 524S303 to 94% (S67014) small protein PII, GlnB-transcriptional

5249641 regulator [Escherichia coli, Peptide,

112 aa] gb|AAC75606.l] (AE000341) regulatory protein P-II for glutamine synthetase

[Escherichia coli K12] dbj | BAA16 61.1 | (D90885) regulatory protein P-II [Escherichia coli] prf | | 1712307B glnB gène [Escherichia coli] #N/A

Contig9 from gb|AAC26596.l| (U83995) putative protease

SΞQ ID n° 10495 PL-895.1 5250002 to 593 [Porphyro onas gingivalis]

5250886 SΞQ ID n~3741

Contig9 from emb|CAC04221.l[ (AL391515) conserved

SEQ ID n° 10496 PL-896.1 5251308 to 583 hypothetical protein [Streptomyces coelicolor

5252381 A3(2)] SEQ ID n~3742

Contig9 from emb]CAC04220.l| (AL391515) conserved

SEQ ID n° 10497 PL-897.1 5252381 to 503 hypothetical protein [Streptomyces coelicolor

5253772 A3 (2)] SEQ ID n~3743

ContigS from gb|AAG56318.l|AΞ005360_10 (AΞ005360) unknown

SEQ ID n° 10498 PL-898.1 5254190 to 51% protein associated with Rhs élément [Escherichia

5255317 coli 0157 :H7] SEQ ID n~3744

Contig9 from SΞQ ID n° 10499 PL-5503.1 5255391 to No Hits found

5255651 #N/A Contig9 from ^"SEQ ID n° 10500 PL-899.1 5255802 to ^"No Hits found

5256389 SEQ ID n~3745 pir| |B83548 hypothetical protein PA0787

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 10501 PL-900.1 5257030 to 39% (strain PAOl) gb |AAG04176.1 | AΞ004513_8

5258037 (AΞ004513) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~3748

Contig9 from SΞQ ID n° 10502 PL-901.1 5258034 to No Hits found

5258684 SEQ ID n~374S ContigS from dbj |BAB06239.l| (AP001515) transposase related SΞQ ID n° 10503 PL-902.1 5258976 to 21% protein (20) [Bacillus halodurans]

5260001 SEQ ID n~3750 Contig9 from SEQ ID n° 10504 PL-7326.1 5260180 to p No Hits found

5260335 #N/A Contig9 from SEQ ID n° 10505 PL-5495.1 5260807 to No Hits found

5261127 #N/A sp|P05823|TNR0_ECOLI TRANSPOSON TN2501 RΞSOLVASE

Contig9 from pir| |RPECR5 resolvase - Escherichia coli SEQ ID n° 10506 PL-903.1 5261475 to 853 transposon Tn2501 gb|AAA27426.l| (M15197)

5262056 resolvase [Transposon Tn2501] SEQ ID n~3751

gb|AAG55350.l|AE005276_3 (AΞ005276) Z1205 gène

ContigS from product [Escherichia coli 0157.-H7]

SEQ ID n° 10507 PL-904.1 5262116 to 16% gb|AAG55760.l|AΞ005312_6 (AΞ005312) Z1645 gène - 5263510 product [Escherichia coli 0157 :H7] SΞQ ID n~3752

Sp|P33596|RECX_ECOLI REGULATORY PROTEIN RECX

(ORAA PROTEIN) pir| |F6504S regulatory protein

Contig9 from

^=~ _ecX - Escherichia coli gb| AAC75740. l|

SEQ ID n° 10508 PL-5494.1 5263507 to 54% (AE000354) regulator, OraA protein [Ξscherichia

5263S29 coli K12] dbj |BAA16560.l| (D90892) REGULATORY PROTEIN RECX (ORAA PROTEIN) . [Ξscherichia coli] #N/A

Contig9 from

SEQ ID n° 10509 PL-7325.1 5264029 to p No Hits found

5264196 #N/A sp | P26353 | HMPA_SALTY FLAVOHEMOPROTEIN

(HΞMOGLOBIN-LIKΞ PROTEIN) (FLAV0HEM0GLOBIN)

Contig9 from

(DIHYDROPTBRIDINΞ RΞDUCTASΞ (FERRISIDEROPHORΞ

SEQ ID n° 10510 PL-905.1 5264585 to m 733

RΞDUCTASE B) (NITRIC OXIDE

5265775

DIOXYGENASΞ) (NOD) gb|AAC24484.1 | (AF020388) flavohemoglobin [Salmonella typhimurium] SΞQ ID n~3753 sp | O6192 | GLYA_SALTY SΞRINE

HYDROXYMETHYLTRANSFΞRASΞ (SΞRINΞ METHYLASE)

(SHMT) pir| |B48427 glycine

ContigS from hydroxymethyltransferase (EC 2.1.2.1) -

SEQ ID n° 10511 PL-906.1 5266147 to 933

Salmonella typhimurium

5267400 emb[CAA33808.l| (X15816) serine hydroxymethyltransferase (AA 1-417) [Salmonella typhimurium] SΞQ ID n~3754

Contig9 from gb|AAG57649.l|AE005483_8 (AE005483) MFS (major

SEQ ID n° 10512 PL-907.1 5267720 to 76% facilitator superfamily) transporter

5268865 [Ξscherichia coli 0157 :H7] SEQ ID n~3755

sp|P36674|TRER_SALTY TREHALOSE OPERON REPRΞΞSOR pir| |A57147 regulatory protein treR - Salmonella typhimurium crb | AAA68987. l| (U07843) Submitter comments : Cloned as part of mgtA locus . ORF

Contig9 from expresses a 37 kda protein. Locus is not

SEQ ID n° 10513 PL-S08.1 5268938 to 733 regulated by Mg2+. Is homolog of E. 5269885 coli treR gène, personal communication from Dr. Winfried Boos and also

Dr. Kenn Rudd, see GenBank Accession

Numb> SΞQ ID n~3756

Contig9 from gb|AAG59437.l|AE005656_5 (AΞ005656) PTS System

SEQ ID n° 10514 PL-909.1 5270034 to 88% enzyme II, trehalose spécifie [Ξscherichia

5271455 coli 0157 :H7] SΞQ ID n-3757 sp | P28904 | TREC_ECOLI TREHAL0SΞ-6-PH0SPHATE

HYDROLASE (ALPHA, ALPHA-PHOSPHOTREHALASΞ)

Contig9 from pir| |S56465 alpha, alpha-phosphotrehalase (ΞC

SEQ ID n° 10515 PL-910.1 5271555 to 76% 3.2.1.93) - Escherichia coli gb| AA97136.1 |

5273216 (U14003) trehalose-6-phosphate hydrolase

[Escherichia coli] gb|AAC77196.l| (AΞ000495) trehalase 6-P hydrolase [Escherichia coli K12] SΞQ ID n~3759 sp|P22783|SUHB_ECOLI EXTRAGENIC SUPPRESSOR

PROTEIN SUHB pirj|D65030 yo-inositol-1 (or 4) - monophosphatase (ΞC 3.1.3.25) [validated] -

Ξscherichia coli gb| AAC75586.l| (AΞ000339)

Contig9 from enhances synthesis of sigma32 in mutant;

SEQ ID n° 10516 PL-911.1 5273319 to 903 extragenic suppressor, may modulate

5274122 RNAse III lethal action [Escherichia coli K12] dbj |BAA16427.l| (D90883) EXTRAGENIC

SUPPRESSOR PROTEIN SUHB. [Escherichia coli] dbj | BAA16435.1 | (D90884 ) EXTRAGΞNIC SUPPRESSOR

PROTΞIN SUHB. [Escherichia coli] SΞQ ID n~3760

Contig9 from gb|AAG57646.l|AE005483_5 (AE005483) putative ATP

SEQ ID n° 10517 PL-912.1 5274256 to 803 synthase beta subunit [Escherichia coli

5274981 0157 :H7] SΞQ ID n~3761

sp|P77484|YFHP_ΞCOLI HYPOTHΞTICAL 17.3 KDA PROTΞIN IN HSCA-SUHB INTΞRGΞNIC RΞGION pir| |B65030 hypothetical protein b2531 -

Escherichia coli (strain K-12) gb|AAC75584.l|

Contig9 from

(AB000339) orf, hypothetical protein SΞQ ID n° 10518 PL-3435.1 5275068 to 783

Escherichia coli K12] dbj |BAAI6425. l| (D90883) 5275562 similar to [SwissProt Accession Number P44675]

[Escherichia coli] gb|AAG57645.l(AΞ005483_4

(AΞ005483) orf, hypothetical protein

[Escherichia coli 0157 :H7] SΞQ ID n~2652 sp|P3917l|NIFS_EC0LI NIFS PROTΞIN HOMOLOG

Contig9 from dbj |BAA16424.l| (D90883) UNKNOWN PROTΞIN FROM 2D

SΞQ ID n° 10519 PL-913.1 5275612 to 963

PAGΞ (SPOT M92) (FRAGMΞNT) .

5276826

[Ξscherichia coli] SEQ ID n~3762 sp|P77310|NIFU_ΞCOLI NIFU-LIKE PROTEIN pir| |H65029 hypothetical protein b2529 -

Escherichia coli (strain κ-12) gb|AAC75582.l|

Contig9 from

(AΞ000339) orf, hypothetical protein SΞQ ID n° 10520 PL-5491.1 5276851 to 903

[Ξscherichia coli K12] dbj |BAA16423. l| (D90883)

5277237

NIFU PROTΞIN. [Escherichia coli] gb|AAG57643.l|AE005483_2 (AE005483) orf, hypothetical protein [Escherichia coli 0157 :H7] #N/A

Contig9 from gb|AAK02404.l| (AEO06068) unknown [Pasteurella SEQ ID n° 10521 PL-5489.1 5277347 to 84% multocida]

5277670 #N/A sp|P36540|HSCB_ECOLI CHAPERONΞ PROTΞIN HSCB (HSC20) pir| |A36S58 DnaJ homolog (hscA 5'- region) - Escherichia coli gb|AA182S3.1 |

Contig9 from

(U01827) ORF-1 [Escherichia coli] SEQ ID n° 10522 PL-3434.1 5277708 to 76% gb|AAC75580.l| (AΞ000333) orf, hypothetical

5278229 protein [Escherichia coli K12] dbj JBAA16421.1 |

(D90883) similar to [SwissProt Accession Number

P36540] [Bscherichia coli] SEQ ID n-2651

sp]P3654l]HSCA_ΞCOLI CHAPERONE PROTEIN HSCA

(HSC66) pir| |E65029 heat shock cognate protein

ContigS from 66 - Ξscherichia coli gb| AAC75579.l| (AΞ000339)

SBQ ID n° 10523 PL-314.1 5278241 to 85% heat shock protein, chaperone, member of Hsp70

52800S1 protein family [Escherichia coli K12]

dbj |BAA16420. l| (D90883) heat shock cognate

^"protein ^"66 [Escherichia coli] SEQ ID n~3763 sp|P25528|FER_ΞCOLI FΞRRΞDOXIN, 2FΞ-2S pir] | C1110 ferredoxin [2Fe-2S] - Escherichia coli gb|A A23755.l| (M88654) ferredoxin

[Escheπchia coli] gb | AAC75578.11 (AE000339)

Contig9 from [2FΞ-2S] ferredoxin, électron carrer protein SEQ ID n° 10524 PL-5488.1 5280094 to 74% [Ξscherichia coli K12] dbj |BAA16415. l| (D90882)

5280429 ferredoxin [2Fe-2S] [Escherichia coli] dbj |BAA16413.l| (DS0883) ferredoxin [2Fe-2S]

[Escherichia coli] gb | AAG5763S .1 | AΞ005482_6

(AE005482) [2FE-2S] ferredoxin, électron carrer protein [Escherichia coli 0157 :H7] #N/A sp|P370S6|YFHJ_ECOLI HYPOTHETICAL 7.7 KDA

PROTEIN IN PPEB-FDX INTBRGENIC RΞGION pir||C65023 hypothetical 7.7 kD protein in fdx

3 ' région - Escherichia coli (strain K-

12) gb|AAC75577.l| (AE00033S) orf, hypothetical

Contig9 from protein [Escherichia coli K12] dbj |BAA16414.l] SΞQ ID n° 10525 PL-5487.1 5280448 to 83%

(D90882) similar to [SwissProt Accession Number

5280648

P37096] [Escherichia coli] dbj |BAA16418.l| (D90883) similar to [SwissProt

Accession Number P37096] [Escherichia coli] gb|AAG57638.l|AΞ005482_5 (AΞ005482) orf, hypothetical protein [Ξscherichia coli 0157 :H7] #N/A

Contig9 from gb|AAG57637.l|AΞ005482_4 (AΞ005482) putative

SEQ ID n° 10526 PL-915.1 5280957 to 823 peptidase [Ξscherichia coli 0157 :H7]

5282252 SΞQ ID n~3764

ContigS from gb|AAG57636.l|AΞ005482_3 (AΞ005482) enhanced

SΞQ ID n° 10527 PL-5486.1 5282288 to p 533 serine sensitivity [Ξscherichia coli 0157 :H7]

5282710 #N/A

pir] ]H8284l conserved hypothetical protein

Contig9 from XF0161 [imported] - Xylella SEQ ID n° 10528 PL-916.1 5282802 to _.. m 71% fastidiosa ( s_t_raj_n_9_a_5cj____ _

5284598 gb|AAF82974.l|AΞ003869_ll (AΞ003863) conserved hypothetical protein [Xylella fastidiosa] SΞQ ID n~3765

Contig9 from

SΞQ ID n° 10529 PL-5485.1 5284585 to m No Hits found

5284836 #N/A pir| |G82841 hypothetical protein XF0160

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 10530 PL-5484.1 5284820 to ^" m 65% (strain 9a5c) gb| AAF8^~2S73.11 AE003869_10

5285137 (AE003863) hypothetical protein [Xylella fastidiosa] #N/A pir| |F82841 hypothetical protein XF0159

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 10531 PL-917.1 5285134 to m 40% (strain 9a5c) gb | AAF82972.1 |AE003869_9

5285781 (AE003869) hypothetical protein [Xylella fastidiosa] SEQ ID n~3766 sp|P4419l|YE20_HAΞIN HYPOTHETICAL PROTEIN HI1420 pirj |C64029 hypothetical protein HI1420 -

Contig9 from

Haemophilus influenzae (strain Rd SEQ ID n° 10532 PL-5483.1 5285864 to m 483

KW20) gb|AAC23070.l| (U32821) H. influenzae

5286073 predicted coding région HI1420

[Haemophilus influenzae Rd] #N/A re |NP_073225.l| ransposase of IS630 [Salmonella enterica serovar Choleraesuis] dbj [BAA01531. l|

Contig9 from

(D10689) M5 protein [Salmonella choleraesuis] SEQ ID n° 10533 PL-918.1 5286855 to P 723 db |BAB20556.1 | (AB040415) ransposase of IS630

5287868

[Salmonella enterica serovar

Choleraesuis] SEQ ID n~3767

Contig9 from gb|AAG00942.l|AF272977__2 (AF272377) transposase SEQ ID n° 10534 PL-919.1 5288236 to 29% [Mycoplasma hyopneumoniae]

5289852 SEQ ID n~3768

sp|Q07295|PRTA_ΞRWCH SΞCRΞTΞD PROTΞASE A

Contig9 from PRΞCURSOR (PROA) pir||S30160 metalloprotemase SEQ ID n° 10535_PL-3_433.1 5289956 to 47% (EC 3.4.24. -) A - Erwinia chrysanthemi_.

5290477 emb]CAA49611.l| (X70011) protease A [Erwinia chrysanthemi] SΞQ ID n~2650

Contig9 from

-^dbj-j-BAB06239.l| (AP001515) transposase related-

SΞQ ID n° 10536 PL-920.1 5290453 to 21% protein (20) [Bacillus halodurans]

5291478 SEQ ID n~3770

Contig9 from pdb | 1AKL | Alkaline Protease From Pseudomonas

SEQ ID n° 10537 PL-S21.1 5291433 to 683 Aeruginosa Ifo3080

5292509 SEQ ID n~3771 Contig9 from

SEQ ID n° 10538 PL-6962.1 5293418 to No Hits found

5293564 #N/A pir| |T14593 syringomycin synthetase -

Contig9 from Pseudomonas syringae pv. syringae SEQ ID n° 10539 PL-923.2 5293684 to 553 gb[AAC80285.l| (AF047828) syringomycin

5309334 synthetase [Pseudomonas syringae pv. syringae] SΞQ ID n~3772 pir| |F82498 conserved hypothetical protein

Contig9 from VCA0107 [imported] - vibrio cholerae SEQ ID n° 10540 PL-3431.1 5310490 to 503 (group 01 strain N16961) gb] AAF96021.1]

5310987 (AE004353) conserved hypothetical protein

[Vibrio cholerae] SEQ ID n~2649 pir| |D83439 conserved hypothetical protein

Contig9 from PA1658 [imported] - Pseudomonas SΞQ ID n° 10541 PL-924.1 5311019 to 583 aeruginosa (strain PAOl)

5312545 gb|AAG05047.l|AΞ004593_9 (AE004593) conserved hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~3773 pir] |E82499 hypothetical protein VCA0114

Contig9 from

[imported] - Vibrio cholerae (group SΞQ ID n° 10542 PL-925.1 5312561 to 443

01 Strain N16S61) gb |AAF36028. l| (AE004353)

5313910 hypothetical protein [Vibrio cholerae] SEQ ID n~3774

Contig9 from SΞQ ID n° 10543 PL-5475.1 5313907 to No Hits found

5314299 #N/A

ContigS from ref |NP_053113. l| orf51 [Ξscherichia coli]

SEQ ID n° 10544 PL-926.1 5314349 to 533 dbj |BAA84886.l] (AB024946) orf51 [Escherichia

5315854 coli] SEQ ID n~37J5_ gb|AAG55308.l|AΞ005273_l (AE005273) unknown in

Contig9 from

ISEc8 [Escherichia coli 0157 :H7]

SEQ ID n° 10545 PL-5473.1 5315918 to m 733

gb|AAG55717.l|AE005309_7 (AΞ005309) unknown in 5316253

ISΞc8 [Escherichia coli 0157 :H7] #N/A

Contig9 from

SEQ ID n° 10546 PL-5472.1 5316247 to No Hits found

5316612 #N/A

Contig9 from gb|AAD39495.l|AFÏ45799_l (AF145799) immunogenic

SΞQ ID n° 10547 PL-S27.1 5316874 to 103 23 kDa lipoprotein PG3 [Porphyromonas

5318652 gingivalis] SΞQ ID n-3776 pir| |B83613 secreted protein Hep PA0263

[imported] - Pseudomonas aeruginosa

(strain PAOl) pir] |C83455 secreted protein Hep

PA1512 [imported] - Pseudomonas aeruginosa

(strain PAOl) pir| |G82987 secreted protein Hep

Contig9 from

PA5267 [imported] - Pseudomonas aeruginosa SEQ ID n° 10548 PL-3427.1 5318671 to 50%

(Strain PAOl) gb |AAG03652. l| AB004464_5

5319162

(AΞO04464) secreted protein Hep [Pseudomonas aeruginosa] gb|AAG04901. l|AΞ004580_l (AΞ004580) secreted protein Hep [Pseudomonas aeruginosa] gb|AAG08652.l|AΞ004939_4 (AE004939) secreted protein Hep [Pseudomonas aeruginosa] SEQ ID n~2647 pir| |A83613 conserved hypothetical protein

Contig9 from PA0262 [imported] - Pseudomonas SEQ ID n° 10549 PL-328.1 5313333 to 42% aeruginosa (strain PAOl)

5321867 gb|AAG03651.l|AΞ004464_4 (AE004464) conserved hypothetical protein [Pseudomonas aeruginosa] SEQ ID n-3777 pir| |B83458 hypothetical protein PA1510

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 10550 PL-929.1 5321870 to 483 (strain PAOl) gb ] AAG04899.1 | AE004579_11

5323480 (AE004579) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~3778

pir| |A83458 hypothetical protein PA1509

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 10551 PL-930.1 5323473 to 21% (strain PAOl) gb| AAG04898.l| AE0_.04579_10_

5324564 (AΞ004579) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n-3780

Contig9 from

SΞQ^~_rTn° 10552 PL-931.1 5324686 to No Hits found

5325792 SEQ ID n~3781 Contig9 from SΞQ ID n° 10553 PL-5464.1 5325880 to No Hits found ^" 5326113 #N/A

Contig9 from SΞQ ID n° 10554 PL-932.1 5326334 to No Hits found

5327452 SΞQ ID n~3782 pir| |G83637 hypothetical protein PA0077

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 10555 PL-933.1 5327449 to 263 (Strain PAOl) gb| AAG03467.1 | AΞ004446_15

5330820 (AΞO 04446) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~3783 pir| |C83458 conserved hypothetical protein

Contig9 from PA1511 [imported] - Pseudomonas SEQ ID n° 10556 PL-934.1 5331556 to 433 aeruginosa (strain PAOl)

5333355 gb|AAG04900.l|AΞ004579_12 (AΞ004579) conserved hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~3784 pir| |F83234 hypothetical protein PA3293

ContigS from [imported] - Pseudomonas aeruginosa SΞQ ID n° 10557 PL-935.1 5333959 to 41% (strain PAOl) gb|AAG06681.l|AΞ004751_7

5334741 (AΞ004751) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~3785 pir| |D83234 hypothetical protein PA3291

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 10558 PL-3422.1 5334751 to 453 (Strain PAOl) gb|AAG06679.l|AΞ004751_5

5335266 (AE004751) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~2645

pir| |D83234 hypothetical protein PA3291

Contig9 from [imported] - Pseudomonas aeruginosa

SΞQ ID n° 10559 PL-3421.JL 5335318 to p 48% (Strain PAOl) gb |AAG06679.1 |AE004751_5

5335830 (AE004751) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~2644

pir| |D83234 hypothetical protein PA3291

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 10560 PL-3420.1 5335882 to 453 (strain PAOl) gb|AAG06679.l|AΞ004751_5

5336394 (AEO 04751) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~26 3 pir| |C83234 hypothetical protein PA3290

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 10561 PL-936.1 5336382 to 493 (Strain PAOl) gb|AAG06678.l]AΞ004751_4

5338871 (AEO04751) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~3786

Contig9 from SEQ ID n° 10562 PL-937.1 5339122 to No Hits found

5340273 SΞQ ID n~3787 pirj |H83437 hypothetical protein PA1669

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 10563 PL-938.1 5340290 to 27% (strain PAOl) gb] AAG05058.l| AE004594_10

5343640 (AE004594) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~3788

Contig9 from SEQ ID n° 10564 PL-6358.1 5343737 to No Hits found

5343853 #N/A pir| |C83458 conserved hypothetical protein

Contig9 from PA1511 [imported] - Pseudomonas SEQ ID n° 10565 PL-S3S.1 534447S to 453 aeruginosa (strain PAOl)

5347004 gb|AAG04900.l]AE004579_12 (AΞ004579) conserved hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~3789 pir| |B83458 hypothetical protein PA1510

ContigS from [imported] - Pseudomonas aeruginosa SEQ ID n° 10566 PL-340.1 5347005 to 43% (strain PAOl) gb | AAG04899.1 | AE004579_11

5348621 (AΞ004579) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~3791

pir| |A83458 hypothetical protein PA1509

Contig9 from [imported] - Pseudomonas aeruginosa

SEQ ID n° 10567 PL-941.1 5348720 to p 333 (strain PAOl) gb| AG04898.1 |AΞ004579_10

5349724 (AE004579) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~3792

Contig9 from ^~SEQ ID n° 10568 PL-5457.1 5350058 to o Hits found

5350297 #N/A Contig9 from SEQ ID n° 10569 PL-942.1 5350317 to No Hits found

5351396 SΞQ ID n~9793 pir| |G83637 hypothetical protein PA0077

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 10570 PL-943.1 5351393 to p 26% (strain PAOl) gb| AAG03467.1 | AE004446_15

5354764 (AEO04446) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~3794

Contig9 from SEQ ID n° 10571 PL-5455.1 5354837 to o Hits found

5354977 #N/A Contig9 from SEQ ID n° 10572 PL-5454.1 5355242 to m No Hits found

5355478 #N/A pir| |E83234 hypothetical protein PA3232

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 10573 PL-3416.1 5355552 to p 46% (strain PAOl) gb JAAG06680.1 |AE004751_6

5356064 (AΞO 04751) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2641 pir| |D83234 hypothetical protein PA3231

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 10574 PL-3415.1 5356116 to p 463 (strain PAOl) gb|AAG06673.11AE004751_5

5356628 (AE004751) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2640

pir| |C83234 hypothetical protein PA3290

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 10575 PL-944.1 5356616 to 49% (strain PAOl) gb | AAG06678.1 ] AΞ004751_4_

5359093 (AEO 04751) hypothetical protein [Pseudomonas aeruginosa]

Contig9 from

SΞQ ID n° 10576 PL-945.1 5359137 to No Hits found

5360120 SΞQ ID n~3796 pir| |A82499 hypothetical protein VCA0110

ContigS from

[imported] - Vibrio cholerae (group SΞQ ID n°__ 10577 PL-S46.1 5360647 to 483

Ol strain N16961) gb |AAF96024.1 | (AE004353)

5362407 hypothetical protein [Vibrio cholerae] SΞQ ID n~3797

Contig9 from gb|AAG54528.l|AΞ005198_9 (AΞ005198) Z0259 gène SΞQ ID n° 10578 PL-947.1 5362371 to 38% product [Ξscherichia coli 0157 :H7]

5363459 SΞQ ID n~3798 pir| |E8363 hypothetical protein PA0080

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 10579 PL-3414.1 5363437 to 323 (strain PAOl) gb | AAG03470.1 |AΞ004447_3

5363976 (AΞ004447) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~2639 pir| |E83439 hypothetical protein PA1659

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 10580 PL-5451.1 5363981 to 343 (strain PAOl) gb| AAG05048.l|AE004593_10

5364409 (AE004593) hypothetical protein [Pseudomonas aeruginosa] #N/A pir| ]C83477 probable transcription regulator

PA1347 [imported] - Pseudomonas

Contig9 from aeruginosa (strain PAOl) SΞQ ID n° 10581 PL-S48.1 5364734 to 373 gb|AAG04736.l|AE004564_5 (AΞ004564) probable

5365402 transcriptional regulator [Pseudomonas aeruginosa] SEQ ID n~3799 pir| |B82381 transcription regulator LuxR family

Contig9 from VCA1078 [imported] - Vibrio cholerae SEQ ID n° 10582 PL-949.1 5365715 to 433 (group 01 strain N16961) gb | AAF96971.1 |

5366401 (AΞ004433) transcriptional regulator, LuxR family [Vibrio cholerae] SΞQ ID n~3800

pir||C83477 probable transcription regulator

SΞQ ID n° 10583 PL-950.1

ContigS ^"from

SEQ ID n° 10584 PL-951.1 5368090 to No Hits found

5368731 SΞQ ID n~3803 pir C82199 RTX toxin RtxA VC1451 [imported] -

_Contig9 from Vibrio^" cholerae (group 01 strain

SΞQ ID n° 10585 PL-952.1 5369876 to 333 N16961) gb|AAF94608.l| (AΞ004223) RTX toxin

5380462 RtxA [Vibrio cholerae] SΞQ ID n~3804

ContigS from

SΞQ ID n° 10586 PL-953.1 5380356 to No Hits found

5381516 SΞQ ID n~S805

Contig9 from

SΞQ ID n° 10587 PL-5444.1 5381516 to p No Hits found

5381917 #N/A ref |NP_066697.l| hypothetical protein

Contig9 from

[Agrobacterium rhizogenes] dbj |BAB16235.l|

SΞQ ID n° 10588 PL-954.1 5382436 to 51%

(AP002086) hypothetical protein [Agrobacterium

5383989 rhizogenes] SΞQ ID n~3806

Contig9 from

SΞQ ID n° 10589 PL-5441.1 5384213 to No Hits found

5384320 #N/A pir] |F64674 aliphatic amidase - Helicobacter

Contig9 from pylori (strain 26635) gb| AAD08283.1 | (AΞ000629)

SΞQ ID n° 10590 PL-955.1 5384475 to 713 aliphatic amidase (aimE) [Helicobacter pylori

5385491

26635] SΞQ ID n~9807

ContigS from gb|AAF81206.l|AF247502_l (AF247502) Ytl2

SΞQ ID n° 10591 PL-956.1 5385982 to 71% [Salmonella dublin]

5386920 SEQ ID n~3808

Contig9 from sp|P4614 |YEFM_EC0LI HYPOTHETICAL 9.3 KD PROTEIN

SΞQ ID n° 10592 PL-5439.1 5387100 to m 743 IN SBCB-HISL INTERGENIC REGION

5387354 #N/A

Contig9 from gb|AAG22i20.l| (AY008264) hypothetical protein

SEQ ID n° 105S3 PL-5438.1 5387618 to 623 [Yersinia enterocolitica]

5387950 #N/A pir C82199 RTX toxin RtxA VC1451 [imported] -

Contig9 from Vibrio cholerae (group 01 strain

SEQ ID n° 105S4 PL-357.1 5388578 to 633 N16961) gb|AAF94608.l| (AE004223) RTX toxin

5395762 RtxA [Vibrio cholerae] SEQ ID n~380S

Contig9 from gb|AAC26596.l| (U83995) putative protease

SEQ ID n° 10595 PL-958.1 5395750 to 593 [Porphyromonas gingivalis]

5396634 SEQ ID n~3810

Contig9 from gb|AAD21057.l| (AF119150) RtxA protein [Vibrio

SΞQ ID n° 10596 PL-959.1 5396739 to 793 cholerae]

5393705 SEQ ID n~3811

Contig9 from gb|AAG55009.l]AE005246_S (AE005246) orf,

SEQ ID n° 10597 PL-960.1 5399772 to 703 hypothetical protein [Escherichia coli 0157 :H7]

5400563 SEQ ID n~3813 sp|P37312|DCTA_ΞCOLI C4-DICARBOXYLATB TRANSPORT

PROTEIN pιr||S47743 C -dicarboxylate transport

Contig9 from protein dctA - Ξscherichia coli gb|AAB18505.l| SEQ ID n° 10598 PL-S61.1 5401024 to 943

(U00033) CG site No. 872 [Escherichia coli]

5402277 gb|AAC76553.l| (AΞ000429) uptake of C4- dicarboxylic acids [Escherichia coli K12] SEQ ID n~3814

Contig9 from

SEQ ID n° 10599 PL-5435.1 5402832 to No Hits found

5403086 #N/A

Contig9 from sp|P43262|VACJ_SHIFL VACJ LIPOPROTΞIN PRΞCURSOR

SEQ ID n° 10600 PL-362.1 5403649 to 71% dbj |BAA03799.l| (D16293) VacJ [Shigella

5404401 flexneri] SEQ ID n~S815

Contig9 from gb|AAG17182.l|AF191030_l (AF191030) outer

SEQ ID n° 10601 PL-S63.1 5404605 to m 783 membrane protein FadL [Enterobacter cloacae]

5405948 SΞQ ID n~3816

Sp | P76503 | FCY_ECOLI PROBABLE 3 -KETOACYL-COA

Co

SBQ ID n° 10602 PL-^"96^"4T_ ^"5 acyltransferase [Escherichia coli K12] SΞQ ID n~3817

ContigS from gbJAAG57469.l|AE005465_9 (AΞ005465) putative

SEQ ID n° 10603 PL-965.1 540778S to 72% enzyme [Ξscherichia coli 0157 :H7]

5410020 SΞQ ID n~3818 sp | P7650 | SIXA_ΞCOLI PHOSPHOHISTIDINE

PHOSPHATASΞ SIXA (RX6) pir| |B65007 hypothetical

ContigS from protein b2340 - Ξscherichia coli (strain K-12)

SEQ ID n° 10604 PL-966.1 5410427 to 56% gb|AAC75400.l| (AΞ000322) orf, hypothetical

5410309 protein [Escherichia coli K12] dbj |BAA24878.l|

(D86298) RX6 [Escherichia coli] SΞQ ID n~3819 sp|P77458|YFCN_ECOLI HYPOTHΞTICAL 21.0 KDA

PROTΞIN IN AROC-SIXA INTΞRGΞNIC RΞGION pir| |A65006 hypothetical protein b2331 -

Contig9 from

Ξscherichia coli (strain K-12) gb|AAC75391. l| SEQ ID n° 10605 PL-3410.1 5410930 to m 87%

(AE000321) orf, hypothetical protein

5411466

[Ξscherichia coli K12] dbj |BAA1618S .1 | (D90864) similar to [SwissProt Accession Number P44126]

[Bscherichia coli] SΞQ ID n~2638 pir| |H82228 imidazolonepropionase VC1205

ContigS from

[imported] - Vibrio cholerae (group

SEQ ID n° 10606 PL-967.1 5411742 to 63%

Ol strain N16961) gb| AAF94364. l| (AΞ004200)

5412389 imidazolonepropionase [Vibrio cholerae] SΞQ ID n~3820 sp | P19452 | HUTG_KLEAE FORMIMINOGLUTAMASE

(FORMIMINOGLUTAMATE HYDROLASE) (HISTIDINE

ContigS from

UTILIZATION PROTEIN G) pir| |A36730 hutG protein

SΞQ ID n° 10607 PL-S68.1 5413000 to P 503

- Klebsiella pneumoniae (fragment)

5413S56 gb[ AAA25074.1 | (M34604) histidine utilization repressor G [Klebsiella aerogenes] SΞQ ID n~3821

sp|P12380|HUTC_KLEAE HISTIDINE UTILIZATION

Contig9 from REPRESSOR pir| |B36730 repressor protein hutC - _SΞQ ID n° 10608 PL-969.1 5414062__to_ p 633 Klebsiella pneumoniae gbj AAA25075.l| (M34604)

5414733 histidine utilization repressor C (hutC)

[Klebsiella aerogenes] SΞQ ID n~S822

sp 1 Q11169 | Y505_MYCTU HYPOTHETICAL 39.5 KDA

PROTEIN RV0505C ^"pir| |D70746 probable

Contig9 from

PHOSPHOSΞRINΞ PHOSPHATASΞ - Mycobacterium SEQ ID n° 10609 PL-5434.1 5414828 to m 433 tuberculosis (strain H37RV)

5415010 emb|CAB0093l.l | (Z77162) serB [Mycobacterium tuberculosis] #N/A pir] |Ξ83007 urocanaεe PA5100 [imported] -

ContigS from

Pseudomonas aeruginosa (strain PAOl) SEQ ID n° 10610 PL-970.1 5415762 to 88% gb|AAG08485.l|AΞ004923_l (AΞ004923) urocanase

5417441

[Pseudomonas aeruginosa] SΞQ ID n~3824

Contig9 from sp|P2131θ[HUTH_PSΞPU HISTIDINΞ AMMONIA-LYASΞ SEQ ID n° 10611 PL-971.1 5417450 to 843 (HISTIDASΞ)

5418994 SΞQ ID n~3825 pir| |F83009 probable amino acid permease PA5097

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 10612 PL-972.1 5419082 to p 783 (strain PAOl) gb|AAG08482. l| AE004922_7

5420476 (AΞ004922) probable amino acid permease [Pseudomonas aeruginosa] SΞQ ID n~3826 Sp|P39199|YFCB_ECOLI HYPOTHETICAL ADBNINΞ- SPΞCIFIC METHYLASE YFCB pir||H65005 site- specific DNA-methyltransferase (adenine- specific) (EC 2.1.1.72),

Contig9 from hypothetical, aroC 3 'région - Ξscherichia SEQ ID n° 10613 PL-973.1 5420696 to 883 coli (strain K-12) gb | AAC75390.1 | (AE000321)

5421640 putative adenine-specific methylase [Ξscherichia coli K12] dbj |BAA16188.l| (D90864) similar to [SwissProt Accession Number P391S9] [Ξscherichia coli] SΞQ ID n~3827

Contig9 from gb|AAG57458.l]AΞ005464_9 (AΞ005464) chorismate SEQ ID n° 10614 PL-974.1 5421715 to 903 synthase [Ξscherichia coli 0157 :H7]

5422800 SΞQ ID n~3828

sp|P14008|YFCA_ECOLI HYPOTHETICAL 28.6 KDA

PROTEIN IN FABB-MEPA INTBRGENIC REGION pir| |S08346 hypothetical 28.6 K protein ( epA 3' région) - Escherichia coli emb|CAA34783. l|

(X16909) unidentified ORF (269 AA) [Escherichia

Contig9 from coli] gb|AAC75387.l| (AE000321) putative

SΞQ ID n-°-1061_-PL-975.1 5422889 to 733 structural protein [Ξscherichia coli K12]

5423692 dbj |BAA16183.l] (D90863) similar to [PIR

Accession Number S08346] [Escherichia

COli] gb|AAG57456.l|AE005464_7 (AΞ005464) putative structural protein [Ξscherichia coli

0157 :H7] SΞQ ID n~382S

Contig9 from dbj [BAA16182.l| (D90863) similar to [SwissProt SEQ ID n° 10616 PL-3408.1 5423715 to 833 Accession Number P44255] [Ξscherichia

5424266 coli] SΞQ ID n~2636 sp|P76496|YFCL_ECOLI HYPOTHΞTICAL 10.0 KD

PROTΞIN IN FABB-MEPA INTERGENIC REGION pir| |C65005 hypothetical protein b2325 -

ContigS from

Escherichia coli (strain K-12) gb|AAC75385.1]

SEQ ID n° 10617 PL-5433.1 5424288 to 71%

(AE000321) orf, hypothetical protein

5424566

[Escherichia coli K12] gb] AAG57454.l| AE005464_5

(AEO 05464) orf, hypothetical protein

[Escherichia coli 0157 :H7] #N/A pir| |B65005 hypothetical protein b2324 -

Escherichia coli (strain κ-12) gb|AAC75384. l|

Contig9 from

(AE000321) putative peptidase [Escherichia coli

SEQ ID n° 10618 PL-976.1 5424641 to m 69%

K12] dbj |BAA16181.l| (D30863) similar to

5426683

[SwissProt Accession Number P44246]

[Bscherichia coli] SEQ ID n~3830

Contig9 from

SEQ ID n° 10619 PL-5432.1 5426735 to No Hits found

5426848 #N/A

pdb|lDD8|A Chain A, Crystal Structure Of Beta- Ketoacyl- [acyl Carrier Protein] Syntha.se I From Escheπchia Coli pdb 11DD8 | B Chain B, Crystal Structure Of Beta-Ketoacyl-

Contig9 from [acyl Carrier Protein] Synthase I

SΞQ ID n° 10620 PL-S77.1 5427421 to 883 From Escherichia Coli pdb | 1DD8 | C Chain C,

5428635 Crystal Structure Of Beta-Ketoacyl- [acyl Carrier Protein] Synthase I From Escherichia

Coli pdb|lDD8|D Chain D, Crystal Structure Of Beta-Ketoacyl- [acyl Carrier Protein] Synthase I From Escherichia Coli SEQ ID n-3831

Contig9 from gb|AAG31207.l|AF020810_8 (AF020810) TctA

SΞQ ID n° 10621 PL-378.1 5429122 to 903 [Salmonella enterica]

5430642 SΞQ ID n~9832

Contigg from gb]AAG31206.l|AF020810_7 (AF020810) TctB

SEQ ID n° 10622 PL-5430.1 5430653 to 76% [Salmonella enterica]

5431084 #N/A

Contig9 from gb|AAG31205.l]AF020810_6 (AF020810) TctC

SEQ ID n° 10623 PL-S79.1 5431098 to m 833 [Salmonella enterica]

5432078 SΞQ ID n~3833

Contig9 from

SEQ ID n° 10624 PL-980.1 5432455 to No Hits found

5433111 SΞQ ID n~3835 sp|P22104| CTD_SALTY TRANSCRIPTIONAL RΞGULATORY

PROTΞIN TCTD pir| |A33861 trans-activating

Contig9 from transcription regulator tctD - salmonella

SΞQ ID n° 10625 PL-981.1 5433564 to 76% typhimurium gb| AAA27232.l| (M28368) membrane

5434241 associated regulatory protein [Salmonella typhimurium] gb | AG31204.11 AF020810_5

(AF020810) TctD [Salmonella enterica] SΞQ ID n~3836

Contig9 from gb|AAG31203.1 | AF020810_4 (AF020810) TctE

SΞQ ID n° 10626 PL-982.1 5434228 to 73% [Salmonella enterica]

5435649 SEQ ID n~3837

pir| |A83109 hypothetical protein PA4287

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 10627 PL-983.1 5435646 to 61% (strain PAOl) gb | AAG07675.l| AΞ004845_1

5436533 (AΞ004845) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~3838

Contιg9 from SEQ ID n° 10628 PL-5427.3 5437292 to No Hits found

5437546 #N/A Contig9 from gb|AAC38631.l| (AF047028) insecticidal toxin SEQ ID n° 10629 PL-5426.1 5437638 to 523 complex protein TccZ [Photorhabdus

5437880 luminescens] #N/A sp | P05459 | PDXB_ECOLI ΞRYTHRONATΞ-4 -PHOSPHATE

DΞHYDROGENASE pir| | DΞΞCPP probable erythronate-

4 -phosphate dehydrogenase (ΞC 1.1.1.-) -

Ξscherichia coli gb| AA24308.l| (M29962) erythronate-4-phosphate dehydrogenase

ContigS from

[Ξscherichia coli] gb | AAB36530.1 | (U76961) 4-

SΞQ ID n° 10630 PL-384.1 5438344 to 80% phosphoerythronate dehydrogenase [Escherichia

543S471 coli] gb|AAC75380.l| (AE000321) erythronate-4- phosphate dehyrogenase [Escherichia coli

K12] dbj |BAA16177.l] (D90863) probable erythronate-4-phosphate dehydrogenase (ΞC

1.1.1.-) [Escherichia coli] SEQ ID n~S839 sp|P08390]USG_ECOLI USG-1 PROTEIN pir||QQECH3 probable dehydrogenase (EC 1.2.1.-) usgl - Ξscherichia coli emb| CAA26521.l| (X02743) usg

Contig9 from protein (aa 1-337) [Ξscherichia coli]

SΞQ ID n° 10631 PL-S85.1 5439523 to 79% gb|AAC75379.l| (AΞO00320) putative PTS System

5440533 enzyme II A component [Escherichia coli K12] dbj |BAA16176.1| (D90863) usgl protein

[Escherichia coli] SEQ ID n~3840

Contig9 from gb|AAG57447.l|AΞ005463_10 (AE005463)

SEQ ID n° 10632 PL-S86.1 5440530 to 79% pseudouridylate synthase I [Escherichia coli

5441369 0157 :H7] SEQ ID n~3841

ContigS from gb|AAG57446.l|AE005463_9 (AE005463) orf,

SEQ ID n° 10633 PL-S87.1 5441404 to 73% hypothetical protein [Escherichia coli 0157 :H7]

5442105 -. SEQ. ID n~3842 sp|P08193]ACCD_ECOLI ACETYL-COENZYME A

CARBOXYLASE CARBOXYL TRANSFERASE SUBUNIT BETA

(ACCASE BETA CHAIN) pir||XMECBD acetyl-CoA carboxylase (EC 6.4.1.2), carboxyltransferase beta chain [validated] - Escherichia coli gb|AAC75376.l| (AΞ000320) acetylCoA

ContigS from carboxylase, carboxytransferase component,

SEQ ID n° 10634—PL-SÉ 5442208 to 803 beta subunit [Ξscherichia coli K12]

5443152 dbj |BAA16173.l| (D90863) acetyl-CoA carboxylase

(EC 6.4.1.2), carboxyltransferase beta chain [Escherichia coli] gb|AAG57445.l|AE005463_8 (AE005463) acetylCoA carboxylase, carboxytransferase component, beta subunit [Escherichia coli 0157 :H7] SEQ ID n~3843 sp|P08192 |FOLC_ECOLI FOLC BIFUNCTIONAL PROTEIN

[INCLUDES: FOLYLPOLYGLUTAMATE SYNTHASE

(FOLYLPOLY-GAMMA-GLUTAMATΞ SYNTHETASΞ) (FPGS) ;

DIHYDROFOLATE SYNTHASE ] pir | | SYECFG tetrahydrofolylpolyglutamate synthase (ΞC

6.3.2.17) / dihydrofolate synthase

(EC 6.3.2.12) - Escherichia coli gb|AAC75375.l|

(AE000320) dihydrofolate : folylpolyglutamate

ContigS from synthetase; dihydrofolate synthetase

SEQ ID n° 10635 PL-S8S.1 5443145 to 70^S

[Escherichia coli K12] dbj |BAA16164.l| (D90862)

5444443

FOLYLPOLYGLUTAMATE SYNTHASE (EC 6.3.2.17)

(FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) /

DIHYDROFOLATE SYNTHASE (EC 6.3.2.12).

[Escherichia coli] dbj | BAA16172.1 | (D90863)

FOLYLPOLYGLUTAMATΞ SYNTHASΞ (EC 6.3.2.17)

(FOLYLPOLY-GAMMA-GLUTAMATΞ SYNTHETASE) (FPGS) /

DIHYDROFOLATΞ SYNTHASΞ (ΞC 6.3.2.12).

[Ξscherichia coli] SEQ ID n~3844

Contig9 from gb|AAG57443.1 |AΞ005463_6 (AΞ005463) putative

SEQ ID n° 10636 PL-9S0.1 5444433 to p 623 lipoprotein [Ξscherichia coli 0157 :H7]

5445116 SΞQ ID n~38_46

Contig9 from gb|AAG57442.l|AΞ005463_5 (AΞ005463) membrane

SEQ ID n° 10637 PL-3407.1 5445331 to 903 protein required for colicin V production

5445837 [Escherichia coli Ol57:H7] SEQ ID n~2635 sp[PÔ049675ϋRl_ECOLI

AMIDOPHOSPHORIBOSYLTRANSFΞRASΞ (GLUTAMINΞ

PHOSPHORIBOSYLPYROPHOSPHATB AMIDOTRANSFFRASE)

(ATASE) (GPATASE) pir| | XQEC

Contig9 from amidophosphoribosyltransferase (EC 2.4.2.14 )

SEQ ID n° 10638 PL-991.1 5445852 to 863

[validated] - Escherichia coli

5447369 gb]AAC75372.l| (AE000320) amidophosphoribosyltransferase = PRPP amidotransferase [Ξscherichia coli

K12] SΞQ ID n-3847

Sp|P09550 |UBIX_ECOLI 3-OCTAPRENYL-4-

HYDROXYBENZOATE CARBOXY-LYASΞ (POLYPRΞNYL

P-HYDROXYBENZOATE DECARBOXYLASE) pir| | MECFD 3- octaprenyl-4-hydroxybenzoate carboxy-lyase (EC

4.1.1.-) - Escherichia coli gb|AAC75371.l| (AΞ000320) 3-octaprenyl-4-

Contig9 from hydroxybenzoate carboxy-lyase

SEQ ID n° 10639 PL-992.1 5447416 to 843 [Escherichia coli K12] dbj |BAA16157.l| (D90862)

5448000 3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE (EC

4.1.1.-) (POLYPRENYL P-

HYDROXYBENZOATE DECARBOXYLASB) .

[Escherichia coli] gb]AAG57440.l|AE005463_3

(AE005463) 3-octaprenyl-4-hydroxybenzoate carboxy-lyase [Ξscherichia coli

0157 : H7] SEQ ID n~3848

sp|P77775|YFCH_ECOLI HYPOTHΞTICAL 32.7 KDA

PROTΞIN IN FOLX-HISP INTΞRGΞNIC RΞGION pir| |F65002 hypothetical p otein_b23_04_ -

Ξscherichia coli (strain K-12) gb|AAC75364.1 |

Contig9 from (AΞ000313) putative sugar nucleotide epimerase

SEQ ID n° 10640 PL-993.1 5447981 to m 74% [Ξscherichia coli K12_]_

5448895 dbj ]BAA16141.l| (D90861) similar to [SwissProt

Accession Number Q10403] [Escherichia coli] dbj |BAA16150.l] (DS0862) similar to

[SwissProt Accession Number Q10403]

[Escherichia coli] SEQ ID n-3843

Contig9 from gb|AAG57431.l|AE005462_6 (AE005462) putative S- SEQ ID n° 10641 PL-994.1 5449048 to m 64% transferase [Escherichia coli θl57:H7]

5449668 SEQ ID n~3850 Contig9 from SEQ ID n° 10642 PL-SS5.1 5443838 to m No Hits found

5451367 SEQ ID n~3851 ContigS from gb|AAG01468.l|AF282857_17 (AF282857) WtsF SEQ ID n° 10643 PL-5420.1 5451437 to m 353 [Pantoea stewartii subsp. stewartii]

5451847 #N/A ContigS from SEQ ID n° 10644 PL-5419.1 5451964 to m No Hits found

5452068 #N/A ref |NP_073225.l| ransposase of IS630 [Salmonella enterica serovar Choleraesuis] dbj |BAA01531.l|

Contig9 from

(D10683) M5 protein [Salmonella choleraesuis] SEQ ID n° 10645 PL-996.1 5452289 to 733 dbj |BAB20556.1 | (AB040415) ransposase of IS630

5453329

[Salmonella enterica serovar

Choleraesuis] SBQ ID n~3852 pir| |F82202 hypothetical protein VC1418

Contig9 from

[imported] - Vibrio cholerae (group 01 SEQ ID n° 10646 PL-3S7.1 5454013 to 233 strain N16961) gb] AAFS4575. l| (AE004220)

5455830 hypothetical protein [Vibrio cholerae] SEQ ID n~3853

pir| |A65002 hypothetical protein b2299 -

ContigS from Escherichia coli (strain K-12) gb|AAC75359.l| SEQ ID n° 10647 PL-998.1 5456372 to 71% (AEO 00319) putative regulator [Escherichia coli

5456938 K12] gb|AAG57428.l|AE005462_3 (AE005462) putative regulator [Escherichia coli 0157 :H7] SEQ ID n~3854

Contig9 from dbj |BAB07353.l| (AP001519) transcriptional SEQ ID n° 10648 PL-5417^~.T^{~ ""}5457108 to m 403 regulator (AraC/XylS family) [Bacillus

5457392 halodurans] #N/A Contig9 from gb|AAG58551.l|AΞ005568_l (AE005568) orf; SEQ ID n° 10649 PL-9S9.1 5457979 to 223 hypothetical protein [Escherichia coli 0157 :H7] ^{" "" "} 5458749 ^"SEQ ID n~3855

Contig9 from SEQ ID n° 10650 PL-3406.1 5458926 to No Hits found

5459450 SEQ ID n~2634 Contig9 from gb|AAG54517.l]AB005197_6 (AΞ005197) Z0248 gène SEQ ID n° 10651 PL-3405.1 5459560 to 66% product [Ξscherichia coli 0157 :H7]

5460039 SΞQ ID n~2633 Contig9 from SEQ ID n° 10652 PL-5415.1 5460282 to No Hits found

5460434 #N/A pir||Ξ82456 conserved hypothetical protein

Contig9 from VCA0477 [imported] - Vibrio cholerae SEQ ID n° 10653 PL-5413.1 5460726 to 323 (group 01 strain N16961) gb | AAF96381.1 |

5461040 (AE004379) conserved hypothetical protein

[Vibrio cholerae] #N/A

Contig9 from SEQ ID n° 10654 PL-5412.1 5461031 to No Hits found

5461210 #N/A

sp|Q47157|YAFO_ECOLI HYPOTHETICAL 15.5 KD

PROTEIN IN DINP-PRFH INTERGΞNIC REGION pir| |B64748 yafO protein - Ξscherichia coli dbj | BAAO7595.1] (D38582) YafO [Escheπchia coli]

Contig9 from gb|AAB08653.l| (U70214) hypothetical

SEQ ID n° 10655 PL-5411.1 5461213 to p 45%

[Escherichia coli] gb| AAC73337.1 | (AE000131) 5461617 orf, hypothetical protein [Bscherichia coli K12] dbj |BAA77902.l| (D83536) Hypothetical 11.2 kd protein in dinP-rrfH intergenic région. [Escherichia coli] #N/A pir||F75337 transposase - Deinococcus

Contig9 from radiodurans (strain RI) SΞQ ID n° 10656 PL-3404.1 5462019 to p 62% gb|AAF11477.l|AE002031_6 (AΞ002031) transposase

5462447

[Deinococcus radiodurans] SEQ ID n-26:- sp|P76144| NΞC_ECOLI HYPOTHΞTICAL 11.3 KD

PROTΞIN IN HIPB-UXAB INTBRGΞNIC REGION

Contig9 from pir| [A64906 hypothetical protein bl518 - SΞQ ID n° 10657 PL-5409.1 5462523 to m 72% Escherichia coli gb | AAC74591.1 | (AE000249) orf,

5462822 hypothetical protein [Escherichia coli K12] gb|AAG56248.l|AE005353_3 (AE005353) orf, hypothetical protein [Ξscherichia coli 0157.-H7] #N/A

Sp|P76143 |YNΞB_ECOLI PUTATIVE ALDOLASE YNEB

ContigS from pir| |H64905 conserved hypothetical protein bl517 SEQ ID n° 10658 PL-1000.1 5462834 to m 91%

- Escherichia coli gb| AAC74590.l| (AE000249)

546370S orf, hypothetical protein [Escherichia coli K12] SΞQ ID n~45

Contig9 from gb|AAG56250.l|AE005353_5 (AΞ005353) putative SΞQ ID n° 10659 PL-1001.1 5463778 to m 73% LACI-type transcriptional regulator

5464737 [Ξscherichia coli 0157 :H7] SEQ ID n~46

Sp|P7765l|YDEZ_ECOLI HYPOTHETICAL ABC

TRANSPORTER PERMΞASE PROTEIN YDEZ pir] |F64905 probable sugar transport permease protein bl515

Contig9 from

Ξscherichia coli dbj |BAA15202.ι| (D90794) SΞQ ID n° 10660 PL-1002.1 5464860 to m 87%

Ribose transport system permease protein RbsC.

5455861

[Bscherichia coli] gb| AAC74588.1 | (AΞ000249) putative transport system permease protein

[Ξscherichia coli K12] SEQ ID n~37

sp]P77672 [YDΞY_ΞCOLI HYPOTHΞTICAL ABC TRANSPORTΞR PΞRMEASΞ PROTEIN YDEY pir||Ξ64S05 probable sugar transport permease protein bl_514_

Contig9 from Escherichia coli dbj |BAA15201.1 | (D90794) L- SΞQ ID n° 10661 PL-1003.1 5465861 to m 863 arabinose transport system permease protein

5466862 AraH. [Escherichia coli] gb|AAC74587.l| (AE000249) putative transport system permease protein [Escherichia coli K12] SEQ ID n~48 sp|P77257|EGO_ECOLI PUTATIVE ABC TRANSPORTER ATP BINDING PROTEIN EGO (EGO10A) pir| |D64905 probable sugar transport ATP-binding protein bl513 - Escherichia coli

Contig9 from dbj |BAA15200.1 | (DS0794) Ribose transport ATP- SEQ ID n° 10662 PL-1004.1 5466856 to 77% binding protein RbsA. [Escherichia

5468391 coli] gb|AAC74586.l| (AΞ000249) putative ATP- binding component of a transport system [Escherichia coli K12] gb | AAC61747.1 | (AF089855) aérobic growth essential protein [Escherichia coli] SBQ ID n~49

Contig9 from gb|AAG56254.l|AΞ005353_9 (AΞ005353) putative

SEQ ID n° 10663 PL-1005.1 5468617 to 75% transcriptional regulator, sorC family

5469624 [Ξscherichia coli 0157 :H7] SΞQ ID n~30

Contig9 from gb|AAG56255.l|AE005353_10 (AE005353) putative

SEQ ID n° 10664 PL-1006.1 5469840 to 843 kinase [Ξscherichia coli 0157 :H7]

5471432 SEQ ID n~31

Contig9 from

SEQ ID n° 10665 PL-5406.1 5471627 to No Hits found

5471764 #N/A

Contig9 from dbj ]BAB06239.l| (AP001515) transposase related

SΞQ ID n° 10666 PL-1007.1 5472216 to 21% protein (20) [Bacillus halodurans]

5473241 SEQ ID n~52

ContigS from

SΞQ ID n° 10667 PL-1008.1 5473316 to No Hits found

5474377 SEQ ID n~S3

Contig9 from gb|AAA25769.l| (M29728) citrate synthase SΞQ ID n° 10668 PL-1009.1 5474539 to p 463 [Pseudomonas aeruginosa]

5475750 SEQ ID n~34 Contig9 from SEQ ID n° 10669 PL-1010.1 5

Contig9 from yfiS - Bacillus subtilis emb|CAB12667.l| SEQ ID n° 10670 PL-1011.1 5477136 to 303 (Z99108) similar to multidrug résistance protein

5478302 [Bacillus subtilis] dbj |BAA24459.l|

(D850827 ^"ΫfiS [Bacillus subtilis] SEQ ID n~S7 pir| |B83121 probable AMP-binding enzyme PA4198

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 10671 PL-1012.1 5478295 to 55% (Strain PAOl) gb|AAG07585.l|AE004836_4

5479905 (AE004836) probable AMP-binding enzyme

[Pseudomonas aeruginosa] SEQ ID n~58

Contig9 from sp | Q51955 | PCAK_PSEPU 4-HYDROXYBENZOATE SΞQ ID n° 10672 PL-1013.1 5480215 to 65% TRANSPORTER gb | AAA85137.1 | (U10895) PcaK

5481537 [Pseudomonas putida] SEQ ID n~59 Contig9 from SΞQ ID n° 10673 PL-5401.1 5482174 to No Hits found

5482512 #N/A ref |NP_047874.l| putative transposase [Yersinia pestis] pir| |T14989 probable transposase -

Contig9 from

Yersinia pestis plasmid pMTl gb| AAC82732.1 | SEQ ID n° 10674 PL-5400.1 5482717 to m 463

(AF074611) putative transposase [Yersinia

5482956 pestis] emb|CAB55253.l| (AL117211) hypothetical protein YPMT1.71 [Yersinia pestis] #N/A

ContigS from gb|AAF81206.l|AF247502_l (AF247502) Ytl2 SEQ ID n° 10675 PL-1014.1 5483098 to 693

[Salmonella dublin]

5484072 SEQ ID n~60 Contig9 from gb|AAG54517.l|AE005197_6 (AE005197) Z0248 gène SEQ ID n° 10676 PL-5399.1 5484550 to 45% product [Escherichia coli 0157 :H7]

5484651 #N/A

Contig9 from SΞQ ID n° 10677 PL-7314.1 5485703 to No Hits found

C SΞQ ID n° 10678 PL- 1015.1

C SEQ ID n° 10679 PL-1017.1

5504188 difficile] SΞQ ID n~82 pir||F821S8 probable toxin secretion transporter

Contig9 from VC1446 [imported] - Vibrio ^"" cholerae SΞQ ID n° 10680 PL-1018.1 5504308 to m 71% (group 01 strain N16361) gb| AAFS4603.l|

5506467 (AΞ004223) toxin secretion transporter, putative

[Vibrio cholerae] SΞQ ID n~63 pir| |G821S8 RTX toxin transporter VC1447

[imported] - Vibrio cholerae (group

Contig9 from

01 strain N16361) gb |AAD21060.1 | (AF113150) SΞQ ID n° 10681 PL-1019.1 5506467 to 583

RtxD protein [Vibrio cholerae] gb|AAF3460 .1

5507855

(AΞ004223) RTX toxin transporter [Vibrio cholerae] SΞQ ID n~84 pir| |H821S8 RTX toxin transporter VC1448

Contig9 from

[imported] - Vibrio cholerae (group SEQ ID n° 10682 PL-1020.1 5507855 to 71%

01 Strain N16361) gb | AAF94605. l| (AΞ004223) RTX

5509975 toxin transporter [Vibrio cholerae] SEQ ID n~66

Contig9 from SEQ ID n° 10683 PL-5385.1 5510308 to No Hits found

5510505 #N/A pir| |T14593 syringomycin synthetase -

Contig9 from Pseudomonas syringae pv. syringae SΞQ ID n° 10684 PL-1021.1 5511363 to 553 gb|AAC80285. l| (AF047828) syringomycin

5528342 synthetase [Pseudomonas syringae pv. syringae] SEQ ID n~67

ContigS from SΞQ ID n° 10685 PL-5381.1 5523840 to p No Hits found

5523S71 #N/A

Contig9 from

SEQ ID n° 10686 PL-5380.1 5530311 to No Hits found 5530478 .M h

Contig9 from gb|AAG54900.l|AΞ005236_l (AΞ005236) Z0705 gène

SEQ ID n° 10687 PL-1024.1 5530494 to 36%

product [Ξscherichia coli 0157 :H7]

55349S0 EQ ID n~70

Contig9 from

SEQ ID n° 10688 PL-5377.1 5534995 to No Hits found

5535342 #N/A

Contig9 from

SEQ ID n° 10689 PL-5376.1 5535389 to m No Hits found

5535706 #N/A

Contig9 from

SEQ ID n° 10690 PL-5375.1 5535958 to No Hits found

5536198 #N/A

Contig9 from

SΞQ ID n° 10691 PL-5374.1 5536208 to No Hits found

5536588 #N/A

Contig9 from ref JNP_053113.l| orf51 [Escherichia coli]

SΞQ ID n° 10692 PL-1025.1 5536774 to m 533 dbj ]BAA84886.l| (AB024946) orf5l [Escherichia

5538279 coli] SEQ ID n~71 gb|AAG55308.l|AE005273_l (AΞ005273) unknown in

Contig9 from

ISΞc8 [Escherichia coli 0157 :H7]

SEQ ID n° 10693 PL-5371.1 5538343 to 733 gb|AAG55717.l]AE005309_7 (AE005309) unknown in

5538678

ISEC8 [Escherichia coli 0157 :H7] #N/A

Contig9 from

SEQ ID n° 10694 PL-5370.1 5538672 to No Hits found

5538974 #N/A

Contig9 from

SEQ ID n° 10695 PL-5369.1 5539044 to No Hits found

5539412 #N/A

Contig9 from

SEQ ID n° 10696 PL-5368.1 5539400 to No Hits found

5539648 #N/A

Contig9 from SΞQ ID n° 10697 PL-5367.1 5539998 to m No Hits found

5540102 #N/A Contig9 from gb|AAB51148.l| (U30416) N- (alpha) - SEQ ID n° 10698 PL-1026.1 5541741 to 78% acetylornithine- (delta) -aminotransferase

5542343 [Bscherichia coli] SΞQ ID n~72 sp|P76218|ASTA_EC0LI ARGININE N-

SUCCINYLTRANSFERASΞ (AOST) pir||C64934

ContigS from hypothetical protein bl747 - Ξscherichia coli SΞQ ID n° 10699 PL-1027.1 5542971 to 63% (strain K-12) gb| AC74817.l| (AΞ000269) orf,

5544002 hypothetical protein [Escherichia coli K12] gb|AAG56733.l|AE005397_10 (AΞ005397) orf, hypothetical protein [Escherichia coli 0157 :H7] SEQ ID n~73 pir| |T46996 hypothetical protein aruD [imported]

- Yersinia pestis emb| CAA21339.l| (AL031866)

ORF16, len:505 aa, aruD, probable

Contig9 from succinylglutamate 5-semialdehyde SEQ ID n° 10700 PL-1028.1 5544005 to 75% dehydrogenase, belongs to Pseudomonas

5545480 aeruginosa aru gène cluster, highly similar to many, eg: AruD Pseudomonas aeruginosa, Fasta scores: opt: 2117,

E() :0, 63.5% identity in > SEQ ID n~74 pir] |T46995 hypothetical protein aruB [imported]

- Yersinia pestis emb|CAA21338.l| (AL031866)

0RF15, len: 447 aa, aruB, probable

Contig9 from succinyarginine dihydrolase, belongs SEQ ID n° 10701 PL-102S.1 5545531 to 74% to Pseudomonas aeruginosa aru gène

5546874 cluster similar to many eg. Pseudomonas aeruginosa O50175, Fasta scores opt:

1764, E(): 0, 60.8% identity in 446 aa overlapand Ξ. col> SEQ ID n~75

pir| |T46994 hypothetical protein aruΞ [imported] - Yersinia pestis emb|CAA21337.l| (AL031866) ORF14, len:330 aa, aruE, probable._.

Contig9 from succinylglutamate desuccinylase , SEQ ID n° 10702 PL-1030.1 5546887 to 633 belongs to Pseudomonas aeruginosa aru

5547864 gène cluster. similar to many, eg. AF011922_8

Pseudomonas aeruginosa aruB gène,

Fasta scores: opt: 697, E():0, 38.0% identity in 324 aa o> SEQ ID n~77 sp | P39312 | CYCA_ECOLI D-SERINΞ/D-ALANINΞ/GLYCINE

TRANSPORTER pir| |s56433 D-serine/D- alanine/glycine transporter - Escherichia coli

Contig9 from gb|AAA97104.l[ (U14003) ORF_o470 [Escherichia SEQ ID n° 10703 PL-1031.1 5547969 to 683 coli] gb|AAC77165.l| (AE0004S2) transport of D-

5549423 alanine, D-serine, and glycine [Escherichia coli K12] gb|AAG5S406.1 |AΞ005653_7 (AΞ005653) transport of D-alanine, D-serine, and glycine [Escherichia coli 0157:H7] SEQ ID n~78

Contig9 from SEQ ID n° 10704 PL-1032.1 5550320 to No Hits found

5551204 SEQ ID n~79 pir| |A71652 iron-sulfur cofactor synthesis

Contig9 from protein RP486 - Rickettsia prowazekii SEQ ID n° 10705 PL-1033.1 5551204 to 56% emb|CAA14939.l| (AJ235272) NIFS PROTEIN HOMOLOG

5552370

(spll) [Rickettsia prowazekii] SEQ ID n~80

Contig9 from gb|AAD28459.l|AF127374_14 (AF127374) MitM SΞQ ID n° 10706 PL-1034.1 5552382 to 42% [Streptomyces lavendulae]

5553206 SEQ ID n~81 Contig9 from SΞQ ID n° 10707 PL-1035.2 5553870 to No Hits found

5554499 SΞQ ID n~82 Contig9 from SΞQ ID n° 10708 PL-3215.3 5555306 to No Hits found

5555950 #N/A

ref |NP_073225.l] ransposase of IS630 [Salmonella

Co SEQ ID n° 10709 PL-3216.i 5

Choleraesuis] SEQ ID n-2469 pir] |S73104 DNA-directed RNA polymerase (EC

Contig9 from 2.7.7.6) III large chain RPC1 - SEQ ID n° 10710 PL-5362.2 5557619 to 24% Euplotes octocarinatus (fragment)

5558293 emb|CAA478S7.l| (X67660) DNA-directed RNA polymerase [Euplotes octocarinatus] #N/A

Contig9 from SΞQ ID n° 10711 PL-2492.1 5558899 to No Hits found

5559555 SEQ ID n~2676 Contig9 from gb|AAG57426.l|AΞ005462_l (AΞ005462) SΞQ ID n° 10712 PL-2491.1 5559864 to 90% phosphotransacetylase [Escherichia coli 0157.-H7]

5562005 SEQ ID n~2675 sp|P15046|ACKA_ECOLI ACETATE KINASE

(ACETOKINASE) pir| | KIΞCAA acétate kinase (EC

2.7.2.1) - Escherichia coli gb| AAA23406.1 |

Contig9 from

(M22356) acétate kinase (EC 2.7.2.1) SEQ ID n° 10713 PL-2490.1 5562077 to 88% [Escherichia coli] gb| AAC75356.l| (AE000318)

5563279 acétate kinase [Escherichia coli K12] dbj |BAA16135.1| (D90861) acétate kinase (EC

2.7.2.1) [Escherichia coli] SΞQ ID n~2674 pir| |E65001 hypothetical protein b2235 -

Escherichia coli (strain K-12) gb [AAC75355.1 j

(AΞ000318) orf, hypothetical protein

Contig9 from

[Escherichia coli K12] dbj ]BAA16130. l] (D90860)

SΞQ ID n° 10714 PL-4001.1 5563669 to 723 similar to [SwissProt Accession Number P44127]

5564124

[Escherichia coli] dbj |BAA16134.1 | (D90861) similar to [SwissProt Accession Number P44127]

[Escherichia coli] SΞQ ID n~3157

Contig9 from gb|AAG57421.l(AE005461_6 (AE005461) putative

SΞQ ID n° 10715 PL-2489.1 5564302 to 823 transport protein [Bscherichia coli 0157 :H7]

5566134 SEQ ID n~2672

Contig9 from gb|AAG57420.l|AΞ005461_5 (AE005461) putative SΞQ ID n° 10716 PL-2488.1 5566131 to m 853 alpha hélix protein [Escherichia coli 0157 :H7]

5566730 SΞQ ID n~2671 sp|P77727|YFBQ_ECOLI PROBABLE AMINOTRANSFERASΞ

YFBQ pir| |H65000 probable transaminase (EC

2.6.1.-) b2290 [similarity] - Escherichia

-. Contig9 from —₌ coli (strain K-12) gb| AAC75350.l| (AΞ000318)

SEQ ID n° 10717 PL-2487.1 5567638 to m 86% putative aminotransferase [Escherichia coli K12]

5568852 dbj |BAA16127.1| (D90860) ASPARTATE

AMINOTRANSFERASE (EC 2.6.1.1) (TRANSAMINASE A)

(ASPAT) . [Eschenchia coli] SΞQ ID n~2670

Contig9 from gb|AAG57418.l|AE005461_3 (AE005461) NADH SEQ ID n° 10718 PL-2486.1 5569661 to p 77% dehydrogenase transcriptional regulator, LysR

5570590 family [Escherichia coli 0157:H7] SΞQ ID n~2669 sp|085273|NU0A_ERWCA NADH DEHYDROGΞNASΞ I CHAIN

Contig9 from A (NADH-UBIQUINONΞ OXIDORΞDUCTASΞ CHAIN SΞQ ID n° 10719 PL-5358.1 5571294 to p _ 85% A) gb|AAC38640.l| (AF057063) NADH dehydrogenase

5571743 chain A [Pectobacterium carotovorum subsp . carotovorum] #N/A sp| 085274 |NUOB_ΞRWCA NADH DΞHYDROGENASΞ I CHAIN

Contig9 from B (NADH-UBIQUINONB OXIDORBDUCTASE CHAIN SΞQ ID n° 10720 PL-2485.1 5571761 to p 933 2) (NU02) gb|AAC38641.l| (AF057063) NADH

5572435 dehydrogenase chain B [Pectobacterium carotovorum subsp . carotovorum] SΞQ ID n~2668 sp|P33599|NUCD_ECOLI NADH DEHYDROGΞNASΞ I CHAIN

C/D (NADH-UBIQUINONΞ OXIDORΞDUCTASE

Contig9 from CHAIN 3/4) (NU03/NU04) pir] |D65000 NADH SΞQ ID n° 10721 PL-2484.1 5572554 to p 933 dehydrogenase (ubiquinone) (ΞC 1.6.5.3) I, chain

5574353 C-D - Ξscherichia coli gb|AAC75346.l] (AE000317) NADH dehydrogenase I chain C, D [Escherichia coli K12] SEQ ID n~2667 sp|P33903 |NUOE_SALTY NADH DEHYDROGΞNASΞ I CHAIN

Contig9 from

Ξ (NADH-UBIQUINONB OXIDORBDUCTASΞ CHAIN SEQ ID n° 10722 PL-3999.1 5574356 to p 753

5) (NU05) gb|AAA16061.l| (L22504) NADH

5574904 dehydrogenase subunit [Salmonella typhimurium] SEQ ID n~3153

sp|P31979|NUOF_ECOLI NADH DEHYDROGENASΞ I CHAIN F (NADH-UBIQUINONΞ OXIDORΞDUCTASΞ CHAIN 6) (NUQ6) pir] |B65000 NADH dehydrogenase

(ubiquinone) (ΞC 1.6.5.3) I chain F -

Escherichia coli gb |AAC75344.1 | (AE000317) NADH

ContigS from dehydrogenase I chain F [Ξscherichia coli K12]

SEQ ID n° 10723 PL-2483.1 5574301 to 90% dbj |BAA16113.l| (D9085S) NADH DEHYDROGENASE I

5576265 CHAIN F (EC 1.6.5.3) (NADH-UBIQUINONE OXIDORBDUCTASE CHAIN 6) (NU06) . [Escherichia coli] dbj |BAA16118.l| (DS0860) NADH DEHYDROGENASΞ I CHAIN F (ΞC 1.6.5.3) (NADH- UBIQUINONE OXIDOREDUCTASE CHAIN 6) (NU06) . [Escherichia coli] SΞQ ID n~2666

Contig9 from sp|P3330θ|NUOG_SALTY NADH DEHYDROGΞNASΞ I CHAIN

SEQ ID n° 10724 PL-2482.1 5576332 to 853 G (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN

5579067 G) (NU07) SΞQ ID n~2665 sp|P33603]NUOH_ECOLI NADH DEHYDROGΞNASΞ I CHAIN H (NADH-UBIQUINONB OXIDOREDUCTASE CHAIN H) (NU08) pir| |H64999 NADH dehydrogenase (ubiquinone) (ΞC 1.6.5.3) I chain H - Bscherichia coli gb|AAC75342.l| (AE000317) NADH

Contig9 from dehydrogenase I chain H [Escherichia coli K12] SEQ ID n° 10725 PL-2481.1 5579064 to 93% dbj | BAA16110.1 | (D90859) NADH DEHYDROGΞNASE I

5580041

CHAIN H (EC 1.6.5.3) (NADH-UBIQUINONE

OXIDOREDUCTASE CHAIN 8) (NU08) . [Escherichia coli] gb|AAG57411.l|AE005460_5 (AΞ005460) NADH dehydrogenase I chain H [Escherichia coli

0157 :H7] SΞQ ID n~2664 dbj |BAA16109.l| (D90859) NADH DEHYDROGENASΞ I

Contig9 from

CHAIN I (ΞC 1.6.5.3) (NADH-UBIQUINONΞ SEQ ID n° 10726 PL-3995.1 5580056 to p 943 OXIDOREDUCTASE CHAIN 9) (NU09) . [Escherichia

5580598 coli] SΞQ ID n~3152

sp|P33605|NUOJ_ΞCOLI NADH DΞHYDROGΞNASΞ I CHAIN

J (NADH-UBIQUINONB OXIDORBDUCTASE CHAIN

J) (NUO10) pir |?64S_99_NADH dehydrogenase

(ubiquinone) (EC 1.6.5.3) I chain J -

Contig9 from Escherichia coli gb | AAC75340.l| (AΞ000317) NADH

SΞQ ID n° 10727 PL-3994.1 5580611 to 80% dehydrogenase I chain J [Escherichia coli K12]

5581156 dbj |BAA16108.l| (D90859) NADH dehydrogenase

(ubiquinone) (EC 1.6.5.3) chain J

[Escherichia coli] gb|AAG57409.l|AE005460_3

(AΞ005460) NADH dehydrogenase I chain J

[Escherichia coli 0157 :H7] SΞQ ID n~3151 dbj |BAA16107.1| (D90859) NADH DEHYDROGENASE I

Contig9 from

CHAIN K (ΞC 1.6.5.3) (NADH-UBIQUINONE SEQ ID n° 10728 PL-5351.1 5581153 to 91% OXIDOREDUCTASE CHAIN 11) (NUOil) . [Escherichia

5581455 coli] #N/A

Contig9 from gb|AAG57407.l|AE005460_l (AΞ005460) NADH SEQ ID n° 10729 PL-2480.1 5581452 to 87% dehydrogenase i-chain L [Ξscherichia coli

55832S3 0157 :H7] SΞQ ID n~2663 sp|P31978|NUOM_ECOLI NADH DEHYDROGΞNASΞ I CHAIN

M (NADH-UBIQUINONΞ OXIDORΞDUCTASE CHAIN

M) (NU013) pir| |C64999 NADH dehydrogenase

(ubiquinone) (EC 1.6.5.3) chain 4 - Escherichia

Contig9 from coli gb|AAC75337.l| (AΞ000317) NADH SEQ ID n° 10730 PL-2479.1 5583320 to 893 dehydrogenase I chain M [Escherichia coli K12]

5584840 dbj |BAA16105.l| (D90859) NADH dehydrogenase

(ubiquinone) (EC 1.6.5.3) chain 4

[Escherichia coli] gb| AAG57406.1 |AΞ005459_9

(AΞ005459) NADH dehydrogenase I chain M

[Ξscherichia coli 0157 :H7] SΞQ ID n~2661

sp|P33608|NUON_ΞCOLI NADH DEHYDROGΞNASΞ I CHAIN

N (NADH-UBIQUINONΞ OXIDORBDUCTASΞ CHAIN

14) (NU014) pir| |B64999 NADH dehydrogenase

(ubiquinone) (EC 1.6.5.3) I chain N -

Escherichia coli gb | AAC75336.1 | (AE000317) NADH

_ ContigS from dehydrogenase I chain N [Escherichia coli K12]

SEQ ID n° 10731 PL-2478.1 5584847 to p 773 dbj |BAA16103.l| (D90858) NADH DEHYDROGENASE I

5586304 CHAIN N (EC 1.6.5.3) (NADH-UBIQUINONE OXIDOREDUCTASΞ CHAIN 14) (NU014) . [Ξscherichia coli] dbj |BAA16104.l| (D90859) NADH DBHYDROGΞNASΞ I CHAIN N (EC 1.6.5.3) (NADH- UBIQUINONE OXIDOREDUCTASΞ CHAIN 14)

(NU014) . [Ξscherichia coli] SΞQ ID n~2660 gb[AAF53604.l[ (AΞ003655) CLIP-190 gène product

Contig9 from

[ait 1] [Drosophila melanogaster] SEQ ID n° 10732 PL-2477.1 5586487 to m 46% gb|AAF53605.l| (AΞ003655) CLIP-190 gène product

5587548

[ait 2] [Drosophila melanogaster] SΞQ ID n~2659

Contig9 from pir| |T18372 repeat organellar protein - SEQ ID n° 10733 PL-2476.1 5587595 to m 42% Plasmodium chabaudi gb|AAC63403.l| (U43145)

5588809 repeat organellar protein [Plasmodium chabaudi] SΞQ ID n~2658 sp | P38051 | MΞNF_ΞCOLI MENAQUINONE-SPECIFIC

ISOCHORISMATE SYNTHASΞ dbj ]BAA16092.1 | (D90857)

MENAQUINONΞ-SPΞCIFIC ISOCHORISMATF SYNTHASE (EC

Contig9 from

5.4.99.6). [Escherichia coli] SEQ ID n° 10734 PL-2475.1 5589873 to p 623 dbj |BAA16099.l| (D90858) MENAQUINONE-SPECIFIC

5591192

ISOCHORISMATE SYNTHASE (EC 5.4.99.6).

[Escherichia coli] emb[CAA90702.1 | (Z50849) isochorismate synthase [Escherichia coli] SEQ ID n~2657 dbj |BAA16089.l| (D90857) 2-SUCCINYL-6-HYDROXY-2 ,

4-CYCLOHΞXADIENE-1-CARBOXYLATB

Contig9 from

SYNTHASΞ (SHCHC SYNTHASΞ) / -OXOGLUTARATΞ SΞQ ID n° 10735 PL-2474.1 5591297 to p 78%

DECARBOXYLASE (EC 4.1.1.71) (ALPHA-

5592991

KETOGLUTARATE DECARBOXYLASE) (KDC) .

[Escherichia coli] SEQ ID n~2656

ContigS from gb|AAG57396.l|AE005458_13 (AE005458) putative SΞQ ID n° 10736 PL-2473.1 5592952 to p 50% enzyme [Escherichia coli 0157 :H7]

5593824 SΞQ ID .n~2_6_5_5__ sp | P27290 | MENB_BCOLI NAPHTHOATE SYNTHASE

(DIHYDROXYNAPHTHOIC ACID SYNTHETASE) (DHNA

SYNTHETASΞ) _pir | | A4 714 naphthoate synthase,

DHNA synthase, MenB=menaquinone biosynthesis enzyme/mitochondrial enoyl-CoA hydratase homolog

Escherichia coli pir] |D64997

Contig9 from naphthoate synthase (EC 4.1.3.36) [validated] - SΞQ ID n° 10737 PL-2472.1 5593766 to p 91% Escherichia coli gb| AAA23682. l| (M33421) DHNA

5594623 synthase [Ξscherichia coli] gb|AAC75322.1 |

(AE000316) dihydroxynaphtoic acid synthetase

[Escherichia coli K12] dbj ]BAA16086. l| (DS0857) naphthoate synthase, DHNA synthase,

MenB=menaguinone biosynthesis enzyme/mitochondrial enoyl-CoA hydratase homolog [Escherichia coli] SΞQ ID n~2654 dbj |BAA16085.1 | (D30857) 0-SUCCINYLBΞNZOATE-COA

Contig9 from

SYNTHASΞ (OSB SYNTHASB) (4- (2'- SΞQ ID n° 10738 PL-2470.1 5594623 to 79%

CARBOXYPHENYL) - 4-OXYBUTYRIC ACID SYNTHASE) .

5595594

[Escherichia coli] SΞQ ID n-2652 dbj |BAA16080.l| (D90856) O-SUCCINYLBENZOIC ACID-'

Contig9 from

COA LIGASE (EC 6.2.1.26) (OSB-COA SEQ ID n° 10739 PL-246S.1 55S5582 to 67%

SYNTHΞTASΞ) (O-SUCCINYLBBNZOATΞ-COA SYNTHASΞ) .

5596982

[Ξscherichia coli] SEQ ID n~2650 sp | P423211 CATA_PROMI CATALASΞ pir | | A58663

Contig9 from catalase (EC 1.11.1.6) [validated] - Proteus SEQ ID n° 10740 PL-2468.1 5597066 to 91% mirabilis emb|CAB93973. l| (AJ400964) catalase

5598508 [Proteus mirabilis] emb|CAB93376. l| (AJ400965) catalase [Proteus mirabilis] SEQ ID n~2649

Contig9 from gb|AAG57381.l|AE005457_7 (AΞ005457) orf, SΞQ ID n° 10741 PL-3993.1 5598794 to 65% hypothetical protein [Ξscherichia coli 0157 :H7]

5599336 SEQ ID n~3150

sp|P18199|TYRP_ECOLI TYROSINE-SPΞCIFIC TRANSPORT

PROTΞIN (TYROSINΞ PΞRMΞASΞ) pir | | GRΞCY tyrosine C

SΞQ ID n° 10742 PL-2467.1

coli K12] SEQ ID n~2648

Contig9 from gb]AAC31980.l| (L39897) HecB [Pectobacterium SEQ ID n° 10743 PL-2466.1 5600892 to 603 chrysanthemi]

5602571 SEQ ID n~2647 pir| |C83339 hypothetical protein PA2462

Contig9 from [imported] - Pseudomonas aeruginosa SΞQ ID n° 10744 PL-2465.1 5602632 to 27% (strain PAOl) gb| AAG05850.l| AΞ004673_10

5607719 (AΞ004673) hypothetical protein [Pseudomonas aeruginosa] SEQ ID n~2646

Contig9 from SΞQ ID n° 10745 PL-3992.1 5607719 to No Hits found

5608255 SEQ ID n~3149 pir| |Ξ81193 hypothetical protein NMB0489

Contig9 from [imported] - Neisseria meningitidis SEQ ID n° 10746 PL-5347.1 5608482 to 653 (group B strain MD58) gb| AAF40924. l| (AΞ002405)

5608826 hypothetical protein [Neisseria meningitidis

MC58] #N/A pir| |G81077 hypothetical protein NMB1489

Contig9 from [imported] - Neisseria meningitidis SEQ ID n° 10747 PL-3991.1 5608826 to 483 (group B strain MD58) gb] AAF41845.1 | (AΞ002498)

5609326 hypothetical protein [Neisseria meningitidis

MC58] SΞQ ID n~3148 pir| |G81077 hypothetical protein NMB1489

Contig9 from [imported] - Neisseria meningitidis SEQ ID n° 10748 PL-3990.1 5609490 to 553 (group B strain MD58) gb| AAF41845.l| (AΞ002498)

5609996 hypothetical protein [Neisseria meningitidis

MC58] SEQ ID n~3147

pir| |G81077 hypothetical protein NMB1489

Contig9 from [imported] - Neisseria meningitidis SEQ ID n° 10749 PL-3989.1 5610160 to p 533 (group B strain MD58) gb| AAF41845. l| (AE002498)

5610666 hypothetical protein [Neisseria menin itidis

Contig9 from

— dbj |BAB07562.l| (AP001520) oxidoreductase — SEQ ID n° 10750 PL-2464.1 5610908 to m 37% [Bacillus halodurans]

5611321 SEQ ID n~2645 sp|P55510 |Y4JJ_RHISN PUTATIVE PLASMID STABILITY

Contig9 from PROTEIN Y4JJ pir| |T28637 probable plasmid SΞQ ID n° 10751 PL-5344.1 5612251 to p 773 stability protein Y4jJ - Rhizobium sp. plasmid

5612490 pNGR234a gb | AAB91722.1 | (AE000080) Y4jJ

[Rhizobium sp. NGR234] #N/A sp|P5551l|Y4JK_RHISN PUTATIVE PLASMID STABILITY

ContigS from PROTEIN Y4JK pir| |T28638 probable plasmid SEQ ID n° 10752 PL-5342.1 5612487 to p 75% stability protein y4jκ - Rhizobium sp . plasmid

5612906 pNGR234a gb|AAB91723.l| (AΞ000080) Y4JK

[Rhizobium sp. NGR234] #N/A

Contig9 from SEQ ID n° 10753 PL-2463.1 5613078 to p No Hits found

5613686 SEQ ID n~2644 Contig9 from SEQ ID n° 10754 PL-5341.1 5613686 to p No Hits found

5614066 #N/A Contig9 from gb|AAG57365.l|AΞ005456_2 (AΞ005456) orf, SEQ ID n° 10755 PL-5340.1 5614188 to m 52% hypothetical protein [Ξscherichia coli 0157 :H7]

5614454 #N/A sp | P37427 |RIR2_SALTY RIBONUCLΞOSIDE-DIPHOSPHATE

Contig9 from REDUCTASE 1 BETA CHAIN (RIBONUCLEOTIDE SEQ ID n° 10756 PL-2462.1 5614454 to m 93% REDUCTASE 1) (B2 PROTEIN) (R2 PROTEIN)

5615584 emb|CAA51453.l| (X72948) nrdB [Salmonella typhimurium] SEQ ID n~2643

sp j P00452 | RIR1_ΞC0LI RIBONUCLEOSIDE-DIPHOSPHATE

REDUCTASΞ 1 ALPHA CHAIN (RIBONUCLEOTIDE

REDUCTASΞ_.1) _JBJ.___P_RQTEIN) (RI PROTEIN) pir] |RDEC1R ribonucleoside-diphosphate reductase

(ΞC 1.17.4.1) 1 alpha chain

[validated] - Escherichia coli pdb|2RlR|A Chain

A, Ribonucleotide Reductase RI Protein With Dttp

Occupying The Specificity Site From

Escherichia Coli pdb|2RlR|B Chain B, Ribonucleotide Reductase RI Protein With Dttp

ContigS from Occupying The Specificity Site From SΞQ ID n° 10757 PL-2461.1 5615597 to m 89% Bscherichia Coli pdb|2RlR|c Chain C,

5617888 Ribonucleotide Reductase RI Protein With Dttp Occupying The Specificity Site From

Ξscherichia Coli pdb|3RlR|A Chain A,

Ribonucleotide Reductase RI Protein With Amppnp

Occupying The Activity Site From

Escherichia Coli pdb|3RlR|B Chain B,

Ribonucleotide Reductase RI Protein With Amppnp

Occupying The Activity Site From

Escherichia Coli pdb|3RlR|c Chain c,

Ribonucleotide Reductase RI Protein With Amppnp

Occupying The Activity Site From SEQ ID n~2642 gb|AAG57361.l|AE005455_2 (AΞ005455) 3-

Contig9 from demethylubiquinone-9 3 -methyltransferase and SEQ ID n° 10758 PL-2460.1 5618257 to m 86%

2-octaprenyl-6-hydroxy phénol methylase

5618979

[Escherichia coli 0157 :H7] SEQ ID n~2641

Contig9 from gb|AAB95117.l| (U56906) DNA gyrase [Serratia SΞQ ID n° 10753 PL-2453.1 5619202 to p 33% marcescens]

5621838 SEQ ID n~2639 ContigS from sp]P14376|RCSC_ECOLI SENSOR PROTEIN RCSC SEQ ID n° 10760 PL-2458.1 5622192 to p 67% (CAPSULAR SYNTHESIS REGULATOR COMPONENT C)

5624S51 SEQ ID n~2638 ContigS from gb|AAC82661.l| (AF071215) RcsB [Proteus SEQ ID n° 10751 PL-2457.1 5625036 to m 78% mirabilis]

5625689 SEQ ID n~2637

ContigS from gb|AAC82660.l| (AF071215) regulator of swarming SΞQ ID n° 10762 PL-2456.1 5625694 to m 67% behavior precursor [Proteus

5627370 mirabilis] SEQ ID n-2636 ContigS from gb|AAC82660.l| (AF071215) regulator of swarming SEQ ID n° 10763 PL-2455.1 5627324 to m 64% behavior precursor [Proteus

5628385 mirabilis] SEQ ID n~2635 ref |NP_053304. l| Hypothetical gène

Contιg9 from

[Agrobacterium tumefaciens] dbj |BAA87689. l| SEQ ID n° 10764 PL-2454.1 5628996 to m 45%

(AB016260) Hypothetical gène [Agrobacterium

5629622 tumefaciens] SΞQ ID n~2634 ref |NP_057878. l| crystallin, mu [Mus musculus]

Contιg9 from sp | 054983 |CRYM_MOUSB MU-CRYSTALLIN HOMOLOG SΞQ ID n° 10765 PL-2453.1 5629772 to m 44% gb|AAB94770.l] (AF039391) mu-crystallin [Mus

5630740 musculus] SEQ ID n-2633 ρir| |D83354 hypothetical protein PA2331

Contig9 from [imported] - Pseudomonas aeruginosa SEQ ID n° 10766 PL-3986.1 5630741 to m 45% (strain PAOl) gb |AAG05719.1 | AE004659_5

5631283 (AΞ004659) hypothetical protein [Pseudomonas aeruginosa] SΞQ ID n~3144 sp|P39638|YWFB_BACSU HYPOTHΞTICAL 23.3 KD

PROTEIN IN ROCC-PTA INTERGENIC REGION

Contιg9 from pirj|S39735 ywfB protein - Bacillus subtilis SΞQ ID n° 10767 PL-3985.1 5631352 to m 453 emb|CAA51636.l] (X73124) ipa-80d [Bacillus

5631930 subtilis] emb[CAB15801.l| (Z99123) alternate gène name: ipa-80d [Bacillus subtilis] SEQ ID n~3143 sp| 067733 |ILVΞ_AQUAΞ PROBABLE BRANCHED-CHAIN

AMINO ACID AMINOTRANSFERASΞ (BCAT) pir| |C70463

Contig9 from branched-chain amino acid aminotransferase - SEQ ID n° 10768 PL-2452.1 5631952 to m 553

Aquifex aeolicus gb| AAC07697.1 | (AΞ000762)

5632899 branched-chain amino acid aminotransferase

[Aquifex aeolicus] SEQ ID n~2632 pir||D82622 coenzyme F390 synthetase XF1916

Contig9 from [imported] - Xylella fastidiosa SΞQ ID n° 1076S PL-2451.1 5632896 to m 4£ (strain 9a5c) gb|AAF84722.1 |AΞ004011_7

5634299 (AΞ004011) coenzyme F390 synthetase [Xylella fastidiosa] SΞQ ID n~2631

Contig9 from SEQ ID n° 10770 PL-5333.1 5634313 to m No Hits found 5634735 #N/A

Sp|P37977|YRPX_STRCO HYPOTHETICAL 11.1 KD

Contig9 from PROTEIN IN RPOX 5 ' REGION pir | | S69775

SΞQ ID n° 10771 PL-5332.1 5634725 to m 323 hypothetical protein - Streptomyces coelicolor

5635102 gb| AAA93051.1 | (L11648) putative [Streptomyces coelicolor A3 (2)] /A ref |NP_050366.l[ P5 [Bacteriophage APSE-l]

Contig9 from sp | Q9T1U3 | REGQ_BPAPS PROBABLB ANTITERMINATION SΞQ ID n° 10772 PL-^5329.1 5637077 to 65%

PROTBIN Q (P5) gb | AAF03999.1 | F157835_56

5637496

(AF157835) P5 [Bacteriophage APSΞ-1] m/A

Contig9 from SΞQ ID n° 10773 PL-2450.1 5638016 to No Hits found

5638579 SΞQ ID n~î630 pir| |F82651 hypothetical protein XF1688 XF1583

[imported] - Xylella fastidiosa

Contig9 from (strain 9a5c) gb | AF84392.1 | AE003986_22 SEQ ID n° 10774 PL-2449.1 5638583 to 533 (AE003986) hypothetical protein [Xylella

5640052 fastidiosa] gb|AAF84497.l| AΞ003993_16

(AE003993) hypothetical protein [Xylella fastidiosa] SΞQ ID n~2628

Contig9 from SEQ ID n° 10775 PL-5328.1

Contig9 from SEQ ID n° 10776 PL-5327.1 5640610 to No Hits found

ref ]NP_04S303.l| structural protein P5

Contig9 from

[Alteromonas phage PM2] SEQ ID n° 10777 PL-2448.1 5641219 to 12% gb|AAD43555.l|AF155037_18 (AF155037) structural

5642988 protein P5 [Alteromonas phage PM2] SΞQ ID n~2627

Contig9 from SΞQ ID n° 10778 PL-5324.1 5643581 to No Hits found

5643886 #N/A

pir| |D82661 hypothetical protein XF1593

ContigS from [imported] - Xylella fastidiosa SEQ ID n° 1077S PL-2446.1 5643977 to p 433 (strain 9a5c) gb| AAF84402.1 | E003987_6

5644933 (AE003987) hypothet^"icaï^"protein [Xylella fastidiosa] SΞQ ID n~Sl626

pir| |E82661 hypothetical protein XF1594

Contig9 from [imported] - XylëTaT^'fastidiosa SEQ ID n° 10780 PL-2445.1 5644930 to p 46% (strain 9a5c) gb| AAF84403.1 |AE003987_7

5645685 (AEO 03987) hypothetical protein [xylella fastidiosa] SEQ ID n~2625 pir| |F8 661 hypothetical protein XF1595

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 10781 PL-5323.1 5645775 to p 443 (Strain 9a5c) gb|AAF84404.1 | AE003987_8

5646029 (AEO 03987) hypothetical protein [Xylella fastidiosa] #N/A pir] ]A82649 hypothetical protein XF1704

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 10782 PL-2444.1 5646022 to p 40% (strain 9a5c) gb|AAF84513.11AΞ003994_12

5647215 (AΞ003994) hypothetical protein [Xylella fastidiosa] SEQ ID n~2624 pir| |B82649 hypothetical protein XF1705

Contig9 from [imported] - Xylella fastidiosa SEQ ID n° 10783 PL-3984.1 5647284 to 363 (strain 9a5c) gb] AAF84514. l|AΞ003994_13

5647784 (AE003994) hypothetical protein [Xylella fastidiosa] SΞQ ID n~3142

Contig9 from dbj |BAB35073.l| (AP002555) putative tail fiber SEQ ID n° 10784 PL-2443.5 5647787 to protein [Bscherichia coli 0157 :H7]

5648893 #N/A

Claims

REVENDICATIONS

ll. Séquence nucléotidique isolée issue du génome de Photorhabdus

! luminescens, caractérisée en ce qu'elle comprend une séquence choisie parmi les séquences SEQ ID N° 1 à SEQ ID N° 41 et les séquences SEQ ID N° 5826 à SEQ ID

N° 5834.

2. Séquence nucléotidique isolée issue du génome Photorhabdus luminescens, caractérisée en ce qu'elle est choisie parmi : a) une séquence nucléotidique comportant au moins 75 % d'identité avec une séquence choisie parmi les séquences SEQ ID N° 1 à SEQ ID N° 41 ou les séquences SEQ ID N° 5826 à SEQ ID N° 5834 ; b) une séquence nucléotidique comprenant un fragment représentatif d'une séquence choisie parmi les séquences SEQ ID N° 1 à SEQ ID N° 41 ou les séquences SEQ ID N° 5826 à SEQ ID N° 5834, c) une séquence nucléotidique complémentaire d'une séquence nucléotidique telle que

; définie en a) ou b), d) une! séquence nucléotidique de l'ARN correspondant à l'une des séquences telles ι que 'définies en a), b) ou c) ; e) une séquence nucléotidique telle que définie en a), b), c) ou d) modifiée. 3. Séquence nucléotidique selon la revendication 2, caractérisée en ce qu'il s'agit d'une séquence comprise dans une des séquences SEQ ID N° 1 à SEQ ID N° 41 ou dans les séquences SEQ ID N° 5826 à SEQ ID N° 5834, et en ce qu'elle code pour un polypeptide choisi parmi les polypeptides de séquence SEQ ID N° 42 à SEQ ID N° 3855 ou parmi les polypeptides de séquence codé par une séquence SEQ ID N° 5835 à SEQ ID ⁰ 10784 .

4. Séquence nucléotidique selon la revendication 3, caractérisée : a) en ce qu'elle code pour un polypeptide choisi parmi les polypeptides de séquence SEQ ID N° 61, SEQ ID N° 62, SEQ ID N° 67, SEQ ID N° 171, SEQ ID N° 221, SEQ ID N° 268, SEQ ID N° 288, SEQ ID N° 380, SEQ ID N° 426, SEQ ID N° 438, SEQ ID N° 448,; SEQ ID N° 453, SEQ ID N° 455, SEQ ID N° 456, SEQ ID N° 458, SEQ ID ^:N° 501,! SEQ LD N° 516, SEQ ID N° 530, SEQ ID N° 542, SEQ ID N° 551, SEQ ID N° 720,' SEQ ID N° 761, SEQ ID N° 762, SEQ ID N° 814, SEQ ID N° 859, SEQ ID N° 860, SEQ ID N° 861, SEQ ID N° 862, SEQ ID N° 869, SEQ ID N° 1079, SEQ ID N° 1168, SEQ ID N° 1174, SEQ ID N° 1176, SEQ ID N° 1413, SEQ ID N° 1414, SEQ ID N° 1415, SEQ ID N° 1416, SEQ ID N° 1417, SEQ ID N° 1457, SEQ ID N° 1651, SEQ ID N° 1856, SEQ ID N° 1869, SEQ ID N° 2021, SEQ ID N° 2080, SEQ ID N° 2152, SEQ ID N° 2162, SEQ ID N° 2173, SEQ ID N° 2251, SEQ ID N° 2295, SEQ ID N° 2306, SEQ ID N° 2317, SEQ ID N° 2328, SEQ ID N° 2340, SEQ ID N° 2342, SEQ ID N° 2351, SEQ ID N° 2500, SEQ ID N° 3228, SEQ ID N° 3230, SEQ ID N° 3311, SEQ ID N° 3317, SEQ ID N° 3318, SEQ ID N° 3319, SEQ ID N° 3320, SEQ ID N° 3322, SEQ ID N° 3323, SEQ ID N° 3326, SEQ ID N° 3327, SEQ ID N° 3328, SEQ E) N° 3375, SEQ ID N° 3376, SEQ ID N° 3377, SEQ ID N° 3378, SEQ ID N° 3422, SEQ ID N° 3489, SEQ ID N° 3503, SEQ ID N° 3609, SEQ ID N° 3623, SEQ ID N° 3624, SEQ ID N° 3772, SEQ ID N° 3783, SEQ ID N° 3788 et SEQ ID N° 3794 ; u b) en ce qu'elle est choisie parmi les séquences SEQ ID N° 5835 à SEQ ID N° !l0784 Homologues aux séquences telles que définies en a) comme indiquées à la dernière colonne du' tableau II. 5. Séquence nucléotidique, caractérisée en ce qu'elle comprend une séquence nucléotidique choisie parmi : a) une séquence nucléotidique selon la revendication 3 ou 4 ; b) une séquence nucléotidique comportant au moins 75 % d'identité avec une séquence nucléotidique selon la revendication 3 ou 4; c) une séquence nucléotidique complémentaire ou d'ARN correspondant à une séquence telle que définie en a) ou b) ; d) une séquence nucléotidique d'un fragment représentatif d'une séquence telle que définie en a) ou c) ; et ιe) une séquence telle que définie en a), ou c) modifiée. | 6. Polypeptide codé par une séquence nucléotidique selon l'une des revendications 2 à 5.

7. Polypeptide selon la revendication 6, caractérisé : a) en ce qu'il est choisi parmi les polypeptides de séquence SEQ ID N° 61, SEQ ID N° 62, SEQ ID N° 67, SEQ ID N° 171, SEQ ID N° 221, SEQ ID N° 268, SEQ ID N° 288, SEQ ID N° 380, SEQ ID N° 426, SEQ ID N° 438, SEQ ID N° 448, SEQ ID N° 453, SEQ ID N° 455, SEQ ID N° 456, SEQ ID N° 458, SEQ ID N° 501, SEQ ID N° 516, SEQ ID N° 530, SEQ ID N° 542, SEQ ID N° 551, SEQ ID N° 720, SEQ ID N° 761, SEQ ID N° 762, SEQ ID N° 814, SEQ ID N° 859, SEQ ID N° 860, SEQ ID N° 861, SEQ ID N° 862, SEQ ID N° 869, SEQ ID N° 1079, SEQ ID N° 1168, SEQ ID N° 1174, SEQ ID N° 1176, SEQ ID N° 1413, SEQ ID N° 1414, SEQ ID N° 1415, SEQ ID N° 1416, SEQ ID N° 1417, SEQ ID N° 1457, SEQ ID N° 1651, SEQ ID N° 1856, SEQ BD N° 1869, SEQ ID N° 2021, SEQ ID N° 2080, SEQ ID N° 2152, SEQ ID N° 2162, SEQ ID N° 2173, SEQ ID N° 2251, SEQ ID N° 2295, SEQ ID N° 2306, SEQ ID N° 2317, SEQ ID N° 2328, SEQ ID N° 2340, SEQ ID N° 2342, SEQ ID N° 2351, SEQ ID N° 2500, SEQ ID N° 3228, SEQ ID N° 3230, SEQ ID N° 3311, SEQ ID N° 3317, SEQ ID N° 3318, SEQ ID N° 3319, SEQ ID N° 3320, SEQ ID N° 3322, SEQ ID N° 3323, SEQ

ID N° 3326, SEQ ID N° 3327, SEQ ID N° 3328, SEQ ID N° 3375, SEQ ID N° 3376, ι

SEQ ID N° 3377, SEQ ID N° 3378, SEQ ID N° 3422, SEQ ID N° 3489, SEQ ID N° 3503, SEQ ID N° 3609, SEQ ID N° 3623, SEQ ID N° 3624, SEQ ID N° 3772, SEQ ID

N° 3783, SEQ ID N° 3788 et SEQ ID N° 3794 ; ou b) choisie parmi les polypeptides codés par les séquences SEQ ID N° 5835 à SEQ ID

N° 10784 homologues aux séquences telles que définies en a) comme indiquées à la dernière colonne du tableau II.

8. Polypeptide caractérisé en ce qu'il comprend un polypeptide choisi parmi : a) un polypeptide selon l'une des revendications 6 et 7 ; b) un pqlypeptide présentant au moins 80 % d'identité avec un polypeptide de séquence ' SEQ ID N° 42 à SEQ ID N° 3855 ou avec un polypeptide codé par une séquence

SEQ ID N° 5835 à SEQ ID N° 10784; b) un fragment d'au moins 5 acides aminés d'un polypeptide de séquence SEQ ID

N° 42 à SEQ ID N° 3855 ou d'un polypeptide codé par une séquence SEQ ID N°

5835 à SEQ ID N⁰ 10784 ; d) un fragment biologiquement actif d'un polypeptide de séquence SEQ ID N° 42 à

SEQ ID N° 3855 ou d'un polypeptide codé par une séquence SEQ ID N° 5835 à

SEQ ID N° 10784 ; et e) un polypeptide de séquence SEQ ID N° 42 à SEQ ID N° 3855 ou un polypeptide codé par une séquence SEQ ID N° 5835 à SEQ ID N° 10784, ou tel que défini en c) ou d) modifié.

9. Séquence nucléotidique codant pour un polypeptide selon l'une des revendications 6 à 8. ι 10. Séquence nucléotidique selon l'une des revendications 2 à 5 et 9,

Caractérisée en ce qu'elle code pour un polypeptide de P. luminescens à activité de type itoxine et/ou antibiotique, ou impliqué dans la synthèse de ces toxines et/ou antibiotiques.

11. Polypeptide selon l'une des revendications 6 à 8, caractérisé en ce qu'il s'agit d'un polypeptide de P. luminescens à activité de type toxine et/ou antibiotique, ou impliqué dans la synthèse de ces toxines et/ou antibiotiques, ou l'un de ses fragments.

12. Séquence nucléotidique selon l'une des revendications 1 à 5, 9 et 10 ou séquence de polypeptide selon l'une des revendications 6 à 8 et 11, caractérisée en ce que ladite séquence est enregistrée sur un support d'enregistrement dont la forme et la nature facilitent la lecture, l'analyse et/ou l'exploitation de ladite ou desdites séquences. 13. Séquence nucléotidique ou séquence de polypeptide selon la revendication 12, caractérisée en ce que le support d'enregistrement est un CD-ROM, une disquette informatique ou un serveur informatique.

14. Support d'enregistrement caractérisé en ce qu'y est enregistrée une séquence nucléotidique ou de polypeptide selon la revendication 12 ou 13. 15. Utilisation d'un support selon la revendication 14 pour le choix d'amorces ou de sondes nucléotidiques pour la détermination de gènes dans des souches proches de P. luminescens.

16. Utilisation d'un support selon la revendication 14 pour l'étude du polymorphisme génétique de souches proches de P. luminescens. 17. Utilisation d'un support selon la revendication 14, pour l'étude d'autres génomes en particulier pour l'annotation automatique de gènes provenant d'autres génomes.

18. Séquence nucléotidique utilisable comme amorce ou comme sonde, caractérisée en ce que ladite séquence est choisie parmi les séquences nucléotidiques selon l'une des revendications 1 à 5, 9 et 10.

19. Séquence nucléotidique selon la revendication 18, caractérisée en ce qu'elle est marquée par un composé radioactif ou par un composé non radioactif. _l 20. Séquence nucléotidique selon l'une des revendications 18 et 19, caractérisée en ce qu'elle est immobilisée sur un support, de manière covalente ou non- covalente.

21. Séquence nucléotidique selon la revendication 20, caractérisée en ce qu'elle est immobilisée sur un support tel qu'un filtre à haute densité ou une puce à ADN.

22. Séquence nucléotidique selon l'une des revendications 18 à 21 pour la détection et/ou l'amplification de séquences nucléiques.

23. Puce à ADN ou filtre, caractérisé en ce qu'il contient au moins une séquence nucléotidique selon la revendication 21. 24. Puce à ADN ou filtre selon la revendication 23, caractérisé en ce qu'il contient en outre au moins une séquence nucléotidique d'une cellule de plante, d'un animal ou d'un micro-organisme autre que P. luminescens, immobilisée sur le support de ladite puce.

25. Puce à ADN ou filtre selon la revendication 24, caractérisé en ce que ladite cellule ou micro-organisme autre est choisi parmi une cellule ou micro-organisme sensible , à une toxine ou un antibiotique produit par P. luminescens, une bactérie du genre Photorhabdus, et un variant de P. luminescens.

26. Kit ou nécessaire pour la détection et/ou la quantification de l'expression d'au moins un gène de P. luminescens, caractérisé en ce qu'il comprend une puce à ADN ou un filtre selon l'une des revendications 23 à 25.

27. Vecteur de clonage, et/ou d'expression, caractérisé en ce qu'il contient une séquence nucléotidique selon l'une des revendications 1 à 5, 9 et 10.

28. Vecteur de clonage, et/ou d'expression selon la revendication 27, caractérisé en ce qu'il contient une séquence nucléotidique choisi parmi les séquences SEQ ID N° 3856 à SEQ ID N° 5825, les séquences SEQ ID N° 5835 à SEQ ID N° 10784, ou leur fragment issu du génome de P. luminescens. 29. Cellule hôte, caractérisée en ce qu'elle est transformée par un vecteur selon la revendication 27 ou 28. i

30. Végétal ou animal, excepté rHomme, comprenant une cellule transformée selon la revendication 29.

!

31. Procédé de préparation d'un polypeptide, caractérisé en ce que l'on cultive une cellule transformée par un vecteur selon la revendication 29 dans des conditions permettant l'expression dudit polypeptide et que l'on récupère ledit polypeptide recombinant. 32. Polypeptide recombinant susceptible d'être obtenu par un procédé selon la revendication 31.

33. Procédé de préparation d'un polypeptide selon l'une des revendications 6 à 8, 11 et 32, caractérisé en ce que l'on effectue une synthèse chimique dudit polypeptide.

34. Anticorps monoclonal ou polyclonal, ses fragments, ou anticorps chimérique, caractérisé en ce qu'il est capable de reconnaître spécifiquement un polypeptide selon l'une des revendications 6 à 8, 11 et 32. j 3,5. Anticorps selon la revendication 34, caractérisé en ce qu'il s'agit d'un anticorps marqué.

36. Procédé pour la détection et/ou l'identification de bactéries appartenant à l'espèce P. luminescens dans un échantillon biologique, caractérisé en ce qu'il comprend les étapes suivantes : a) mise en contact de l'échantillon biologique avec un anticorps selon l'une des revendications 34 et 35 ; b) mise en évidence du complexe antigène-anticorps éventuellement formé.

37. Procédé pour la détection de l'expression d'un gène de P. luminescens, caractérisé en ce que l'on met en contact une souche de P. luminescens, avec un anticorps selon la revendication 34 ou 35, et que l'on détecte le complexe antigène/anticorps éventuellement formé.

38. Kit ou nécessaire pour la mise en œuvre d'un procédé selon la revendication 36 ou 37, caractérisé en ce qu'il comprend les éléments suivants : a) un anticorps selon l'une des revendications 34 et 35 ; b) éventuellement, ,les réactifs pour la constitution du milieu propice à la réaction immunologique ;' c) éventuellement, les réactifs permettant la mise en évidence des complexes antigène- anticorps produits par la réaction immunologique.

39. Polypeptide selon l'une des revendications 6 à 8, 11 et 32, ou anticorps selon l'une des revendications 34 et 35, caractérisé en ce qu'il est immobilisé sur un support, notamment une puce à protéine.

40. Puce à protéine, caractérisée en ce qu'elle contient au moins un polypeptide selon l'une des revendications 6 à 8, 11 et 32, ou au moins un anticorps selon l'une des revendications 34 et 35, immobilisé sur le support de ladite puce.

41. Puce à protéine selon la revendication 40, caractérisée en ce qu'elle contient en outre au moins un polypeptide d'une cellule de plante, d'un animal ou d'un micro-origanisme autre que P. luminescens, immobilisée sur le support de ladite puce.

42. Puce à protéine selon la revendication 41, caractérisée en ce que ladite cellule ou micro-organisme autre est choisi parmi une cellule ou micro-organisme sensible à une toxine ou un antibiotique produit par P. luminescens.

43. Kit du nécessaire pour la détection et/ou la quantification de l'expression d'au moins un gène de P. luminescens, caractérisé en ce qu'il comprend une puce à protéine selon l'une des revendications 40 à 42.

44. Procédé de détection et/ou d'identification de bactéries appartenant à l'espèce P. luminescens dans un échantillon biologique, caractérisé en ce qu'il met en œuvre une séquence nucléotidique selon l'une des revendications 1 à 5, 9, 10, 18 et 19.

45. Procédé selon la revendication 44, caractérisé en ce qu'il comporte les étapes suivantes : a) éventuellement, isolement de l'ADN à partir de l'échantillon biologique à analyser, ou obtention d'un ADNc à partir de l'ARN de l'échantillon biologique ; b) amplification spécifique de l'ADN de bactéries appartenant à l'espèce P. luminescens , à l'aide d'au moins une amorce selon l'une des revendications 18 et 19 ; c) mise bn évidence des produits d'amplification.

I 46. Kit ou nécessaire pour la détection et/ou l'identification de bactéries appartenant à l'espèce P. luminescens, caractérisé en ce qu'il comprend les éléments suivants : a) une sonde et/ou amorce nucléotidique selon l'une des revendications 18 à 20 ; b) éventuellement, les réactifs nécessaires à la mise en œuvre d'une réaction d'hybridation ; c) éventuellement, les réactifs nécessaires à une réaction d'amplification de l'ADN.

47. Utilisation d'une séquence nucléotidique selon l'une des revendications 1 à 5, 9 et 10, d'un polypeptide selon l'une des revendications 6 à 8, 11 et 32, d'un anticorps selon l'une des revendications 34 et 35, et/ou d'une cellule selon la revendications 29, pour la sélection de composé organique ou inorganique capable de moduler, de réguler, d'induire ou d'inhiber l'expression de gènes d'une cellule végétale pu animal, ou d'un micro-organisme autre que P. luminescens, dont on veut modifier la résistance ou la sensibilité à au moins une toxine ou antibiotique produit par P. luminescens.

48. Composition comprenant un composé choisi parmi les composés suivants : a) une séquence nucléotidique selon l'une des revendications 1 à 5, 9 et 10 ; b) un polypeptide selon l'une des revendications 6 à 8, 11 et 32 ; c) un vecteur selon la revendication 27 ou 28 ; et d) un anticorps selon la revendication 34 ou 35.

49. Composition pharmaceutique selon la revendication 48, éventuellement en association avec un véhicule pharmaceutiquement acceptable.

50. Composition biopesticide selon la revendication 48.

51. Utilisation d'une cellule selon la revendication 29, ou d'un vecteur selon l'une des revendications 27 et 28, pour la préparation de toxine ou d'antibiotique.

52. Banque génomique d'une bactérie du genre Photorhabdus.

53. Banque d'ADN génomique d'une bactérie du genre Photorhabdus selon la revendication 52, caractérisée en ce que ladite banque d'ADN est clonée dans un plasmide. 54. Banque d'ADN génomique selon la revendication 52 ou 53, caractérisée en ce que ladite bactérie est P. luminescens ou P. luminescens souche TTOl.

55. Banque selon la revendication 52 ou 53, caractérisée en ce qu'il s'agit de la banque déposée à la CNCM le 12 mai 2000 sous le N° 1-2478.

56. Procédé d'identification d'au moins une séquence nucléotidique de P. luminescens non présente dans le génome d'une autre espèce de bactérie, notamment pathogène, et/ou d'identification d'au moins une séquence nucléotidique d'un génome d'une bactérie, notamment pathogène, d'une autre espèce que P. luminescens et non présente dans le génome de P. luminescens, caractérisée en ce qu'elle comprend les étapes suivantes : a) on aligne les séquences nucléotidiques de P. luminescens selon l'une des revendications 1 à 5, 9 et 10 ou contenues dans une banque génomique selon l'une des revendications 54 et 55, avec les séquences génomiques de l'autre espèce de bactérie ; et b) on traite les données obtenues par cet alignement pour isoler et identifier lesdites séquences uniquement présentes dans l'un ou l'autre génome.