DK2328600T3 - Hig2- og urlc10-epitoppeptid og vacciner, der indeholder det - Google Patents
Hig2- og urlc10-epitoppeptid og vacciner, der indeholder det Download PDFInfo
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- DK2328600T3 DK2328600T3 DK09808048.4T DK09808048T DK2328600T3 DK 2328600 T3 DK2328600 T3 DK 2328600T3 DK 09808048 T DK09808048 T DK 09808048T DK 2328600 T3 DK2328600 T3 DK 2328600T3
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- peptide
- cancer
- hla
- peptides
- antigen
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Claims (9)
1. Farmaceutisk middel, hvor midlet omfatter et eller flere peptider med cytotoksisk T-lymfocyt-inducerbarhed (CTL-inducerbarhed), hvor peptidet er et nonapeptid eller decapeptid og omfatter en aminosyresekvens valgt fra gruppen bestående af SEQ ID NO: 2 og 1, eller et eller flere polynukleotider, der koder for et sådant peptid, i kombination med en farmakologisk acceptabel bærer, hvilken bærer er formuleret til anvendelse til et formål valgt fra gruppen bestående af: (i) behandling af cancer hos et individ, hvis HLA-A-antigen er HLA-A0206, (ii) profylakse af cancer hos et individ, hvis HLA-A-antigen er HLA-A0206, (iii) forebyggelse af postoperativt recidiv af cancer hos et individ, hvis HLA-A-antigen er HLA-A0206, og (iv) kombinationer deraf.
2. Farmaceutisk middel ifølge krav 1, hvor canceren er valgt fra gruppen bestående af blærecancer, cervixcancer, cholangiocellulært karcinom, øsofaguscancer, mavecancer, ikke-småcellet lungecancer (NSCLC), osteosarkom, pancreascancer, nyrekarcinom og bløddelstumor.
3. Farmaceutisk middel ifølge krav 1, som er formuleret som en vaccine.
4. In vi tro-fremgangsmåde til induktion af en antigenpræsenterende celle med høj CTL-inducerbarhed, hvor fremgangsmåden omfatter trinet valgt fra gruppen bestående af: (a) etablering af kontakt mellem en antigenpræsenterende celle og et peptid, som omfatter en aminosyresekvens valgt fra gruppen bestående af SEQ ID NO: 2 og 1, hvor peptidet er et nonapeptid eller decapeptid; og (b) indføring af et polynukleotid, der koder for et peptid, hvilket peptid omfatter en aminosyresekvens valgt fra gruppen bestående af SEQ ID NO: 2 og 1, i en antigenpræsenterende celle, hvor peptidet er et nonapeptid eller decapeptid, hvor den antigenpræsenterende celle udtrykker et HLA-A0206- antigen. 5. in vi tro-fremgangsmåde til induktion af CTL ved anvendelse af et peptid, hvilket peptid omfatter en aminosyresekvens valgt fra gruppen bestående af SEQ ID NO: 2 og 1, hvor peptidet er et nonapeptid eller decapeptid, og hvor CTL'en genkender et kompleks af et HLA-A0206-antigen og peptidet.
6. Isoleret antigenpræsenterende celle, som på sin overflade præsenterer et kompleks af et HLA-A0206-antigen og et peptid, hvilket peptid omfatter en aminosyresekvens valgt fra gruppen bestående af SEQ ID NO: 2 og 1, hvor peptidet er et nonapeptid eller decapeptid.
7. Isoleret CTL, som genkender et kompleks af et HLA-A0206- antigen og et peptid, hvilket peptid omfatter en aminosyresekvens valgt fra gruppen bestående af SEQ ID NO: 2 og 1, hvor peptidet er et nonapeptid eller decapeptid.
8. Middel til anvendelse ved in vi vo-induktion af en antigenpræsenterende celle med høj CTL-inducerbarhed, hvor midlet omfatter: (a) et eller flere peptider med CTL-inducerbarhed, hvor peptidet er et nonapeptid eller decapeptid og omfatter en aminosyresekvens valgt fra gruppen bestående af SEQ ID NO: 2 og 1; eller (b) et eller flere polynukleotider, der koder for et sådant peptid; hvor den antigenpræsenterende celle udtrykker et HLA-A0206-antigen, til anvendelse ved en fremgangsmåde til induktion af et immunrespons.
9. Middel til anvendelse til induktion af et immunrespons mod cancer hos et individ, hvis HLA-A-antigen er HLA-A0206, hvor midlet omfatter: (a) et eller flere peptider med CTL-inducerbarhed, hvor peptidet er et nonapeptid eller decapeptid og omfatter en aminosyresekvens valgt fra gruppen bestående af SEQ ID NO: 2 og 1; (b) et eller flere polynukleotider, der koder for et sådant peptid; (c) en eller flere isolerede antigenpræsenterende celler ifølge krav 6; (d) en eller flere isolerede CTL'er ifølge krav 7; eller (e) en kombination deraf i kombination med en farmakologisk acceptabel bærer.
10. Middel ifølge krav 9, hvor canceren er valgt fra gruppen bestående af blærecancer, cervixcancer, cholangiocellulært karcinom, øsofaguscancer, mavecancer, NSCLC, osteosarkom, pancreascancer, nyrekarcinom og bløddelstumor.
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| US8997208P | 2008-08-19 | 2008-08-19 | |
| PCT/JP2009/003897 WO2010021112A1 (en) | 2008-08-19 | 2009-08-14 | Hig2 and urlc10 epitope peptide and vaccines containing the same |
Publications (1)
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| DK2328600T3 true DK2328600T3 (da) | 2016-03-29 |
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| TWI610939B (zh) * | 2007-02-21 | 2018-01-11 | 腫瘤療法 科學股份有限公司 | 表現腫瘤相關抗原之癌症的胜肽疫苗 |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
| PL2640842T3 (pl) * | 2010-11-17 | 2018-11-30 | Aduro Biotech, Inc. | Sposoby i kompozycje do indukowania odpowiedzi immunologicznej na EGFRVIII |
| JP6255594B2 (ja) | 2012-07-10 | 2018-01-10 | オンコセラピー・サイエンス株式会社 | Ｔｈ１細胞のＬＹ６Ｋエピトープペプチドおよびこれを含有するワクチン |
| ES2856834T3 (es) | 2014-08-04 | 2021-09-28 | Oncotherapy Science Inc | Péptido derivado de URLC10 y vacuna que contiene el mismo |
| AU2016306408B2 (en) | 2015-08-10 | 2021-02-11 | Toray Industries, Inc. | Immune inducer |
| IL257335B (en) | 2015-08-12 | 2022-08-01 | Oncotherapy Science Inc | A depdc1-derived peptide and a component containing it |
| SG10201913656TA (en) | 2017-04-26 | 2020-03-30 | Eureka Therapeutics Inc | Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof |
| WO2018234370A1 (en) | 2017-06-20 | 2018-12-27 | Institut Curie | DEFECTIVE IMMUNE CELLS AGAINST SUV39H1 |
| CN115300609A (zh) * | 2021-05-08 | 2022-11-08 | 西湖大学 | 缺氧诱导脂滴相关蛋白(hilpda)在预防或治疗高血脂相关疾病中的应用 |
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| US20070014787A1 (en) | 1998-07-15 | 2007-01-18 | Human Genome Sciences, Inc. | 71 human secreted proteins |
| ATE464383T1 (de) * | 1999-08-05 | 2010-04-15 | Greenpeptide Co Ltd | Tumor antigen |
| WO2001023426A2 (en) | 1999-09-30 | 2001-04-05 | Varian Associates, Inc. | Hypoxia-related human genes, proteins, and uses thereof |
| WO2002030268A2 (en) | 2000-10-13 | 2002-04-18 | Eos Biotechnology, Inc. | Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer |
| US20030232350A1 (en) | 2001-11-13 | 2003-12-18 | Eos Biotechnology, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
| US20070015271A1 (en) | 2002-04-04 | 2007-01-18 | Rosen Craig A | Human secreted proteins |
| US20060024692A1 (en) | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| WO2005019475A2 (en) * | 2003-08-20 | 2005-03-03 | Oncotherapy Science, Inc. | Hypoxia-inducible protein 2 (hig2), a novel therapeutic potential target of renal cell carcinoma (rcc) |
| CA2570392A1 (en) | 2004-06-21 | 2005-12-29 | Green Peptide Co., Ltd. | Peptide vaccine for cancer therapy |
| JP5109131B2 (ja) | 2005-02-10 | 2012-12-26 | オンコセラピー・サイエンス株式会社 | 膀胱癌を診断する方法 |
| DK2325305T3 (da) | 2005-02-25 | 2014-03-03 | Oncotherapy Science Inc | Peptidvacciner til lungecancere, der udtrykker TTK-, URLC10- eller KOC1-polypeptid |
| WO2006093337A1 (ja) | 2005-03-03 | 2006-09-08 | Takeda Pharmaceutical Company Limited | 癌の予防・治療剤 |
| JP2009502112A (ja) | 2005-07-28 | 2009-01-29 | オンコセラピー・サイエンス株式会社 | 腎細胞癌を診断および処置するための方法 |
| JP5116150B2 (ja) | 2005-09-07 | 2013-01-09 | 日本電気株式会社 | Ｈｌａ結合性ペプチド、それをコードするｄｎａ断片および組み換えベクター |
| JP4840858B2 (ja) * | 2006-03-16 | 2011-12-21 | 学校法人慶應義塾 | 癌ワクチン |
| CN103435683B (zh) | 2006-06-16 | 2016-02-03 | 肿瘤疗法·科学股份有限公司 | 来自sparc的癌排斥抗原肽以及含有该肽的药物 |
| TWI610939B (zh) * | 2007-02-21 | 2018-01-11 | 腫瘤療法 科學股份有限公司 | 表現腫瘤相關抗原之癌症的胜肽疫苗 |
| US20100291091A1 (en) | 2007-07-30 | 2010-11-18 | ONCOTHERAPY SCIENCE ,inc. | Cancer associated gene ly6k |
| TW201000115A (en) | 2008-06-11 | 2010-01-01 | Oncotherapy Science Inc | IQGAP3 epitope peptides and vaccines containing the same |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
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2009
- 2009-08-13 TW TW098127226A patent/TWI543767B/zh active
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- 2009-08-14 DK DK09808048.4T patent/DK2328600T3/da active
- 2009-08-14 SG SG10201610206VA patent/SG10201610206VA/en unknown
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- 2009-08-14 JP JP2011507735A patent/JP5633025B2/ja active Active
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- 2009-08-14 RU RU2011110376/10A patent/RU2529373C2/ru not_active IP Right Cessation
- 2009-08-14 AU AU2009283763A patent/AU2009283763B2/en not_active Ceased
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- 2009-08-14 MX MX2011001883A patent/MX337756B/es active IP Right Grant
- 2009-08-14 US US13/059,618 patent/US9119800B2/en active Active
- 2009-08-14 WO PCT/JP2009/003897 patent/WO2010021112A1/en active Application Filing
- 2009-08-14 SG SG2013062690A patent/SG193806A1/en unknown
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- 2011-02-08 IL IL211117A patent/IL211117A/en not_active IP Right Cessation
- 2011-10-26 HK HK11111564.0A patent/HK1157204A1/zh not_active IP Right Cessation
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