DK2303845T3 - Bi- og polycyklisk substitueret isoquinolin og bi- og polycykliske substituerede isoquinolinderivater som rho-kinasehæmmere - Google Patents
Bi- og polycyklisk substitueret isoquinolin og bi- og polycykliske substituerede isoquinolinderivater som rho-kinasehæmmereInfo
- Publication number
- DK2303845T3 DK2303845T3 DK09768941.8T DK09768941T DK2303845T3 DK 2303845 T3 DK2303845 T3 DK 2303845T3 DK 09768941 T DK09768941 T DK 09768941T DK 2303845 T3 DK2303845 T3 DK 2303845T3
- Authority
- DK
- Denmark
- Prior art keywords
- polycyclic substituted
- substituted isoquinoline
- kinase inhibitors
- rho kinase
- derivatives
- Prior art date
Links
- 125000002619 bicyclic group Chemical group 0.000 title 2
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 title 2
- 125000003367 polycyclic group Chemical group 0.000 title 2
- AWJUIBRHMBBTKR-UHFFFAOYSA-N iso-quinoline Natural products C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title 1
- 239000003590 rho kinase inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- AIDS & HIV (AREA)
- Transplantation (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08290607 | 2008-06-24 | ||
US15315509P | 2009-02-17 | 2009-02-17 | |
PCT/EP2009/004393 WO2009156092A2 (en) | 2008-06-24 | 2009-06-18 | Bi- and polycyclic substituted isoquinoline and isoquinolinone derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2303845T3 true DK2303845T3 (da) | 2013-12-16 |
Family
ID=40076742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK09768941.8T DK2303845T3 (da) | 2008-06-24 | 2009-06-18 | Bi- og polycyklisk substitueret isoquinolin og bi- og polycykliske substituerede isoquinolinderivater som rho-kinasehæmmere |
Country Status (27)
Country | Link |
---|---|
US (1) | US8524737B2 (da) |
EP (1) | EP2303845B1 (da) |
JP (1) | JP5715561B2 (da) |
KR (1) | KR101692211B1 (da) |
CN (1) | CN102076667B (da) |
AR (1) | AR072279A1 (da) |
AU (1) | AU2009262509B2 (da) |
BR (1) | BRPI0914330A2 (da) |
CA (1) | CA2728123C (da) |
CO (1) | CO6321251A2 (da) |
DK (1) | DK2303845T3 (da) |
ES (1) | ES2434121T3 (da) |
HK (1) | HK1152308A1 (da) |
HR (1) | HRP20131040T1 (da) |
IL (1) | IL210114A (da) |
MA (1) | MA32401B1 (da) |
MX (1) | MX2010013867A (da) |
MY (1) | MY153756A (da) |
NZ (1) | NZ590067A (da) |
PL (1) | PL2303845T3 (da) |
PT (1) | PT2303845E (da) |
RU (1) | RU2532481C2 (da) |
SI (1) | SI2303845T1 (da) |
TW (1) | TWI466868B (da) |
UY (1) | UY31924A (da) |
WO (1) | WO2009156092A2 (da) |
ZA (1) | ZA201008120B (da) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
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FR2485537B2 (fr) | 1977-04-13 | 1986-05-16 | Anvar | Dipyrido(4,3-b)(3,4-f)indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant |
JPH06501921A (ja) | 1990-07-31 | 1994-03-03 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 選択されたハロカーボンの触媒平衡化 |
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US6541456B1 (en) | 1999-12-01 | 2003-04-01 | Isis Pharmaceuticals, Inc. | Antimicrobial 2-deoxystreptamine compounds |
EP1254904B1 (en) | 2000-01-20 | 2006-05-24 | Eisai Co., Ltd. | Novel piperidine compounds and drugs containing the same |
US7217722B2 (en) | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
US20040171533A1 (en) | 2000-02-29 | 2004-09-02 | Barbara Zehentner | Methods and compositions for regulating adiopocytes |
GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
AR033517A1 (es) | 2000-04-08 | 2003-12-26 | Astrazeneca Ab | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
WO2002034712A1 (fr) | 2000-10-27 | 2002-05-02 | Takeda Chemical Industries, Ltd. | Procede de preparation de composes aromatiques substitues et produits intermediaires associes |
JP2004520347A (ja) | 2001-01-15 | 2004-07-08 | グラクソ グループ リミテッド | Ldl−受容体発現のインデューサーとしてのアリールピペリジンおよびピペラジン誘導体 |
SE0101038D0 (sv) | 2001-03-23 | 2001-03-23 | Astrazeneca Ab | Novel compounds |
EP1389194A2 (en) | 2001-04-27 | 2004-02-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of bace |
EP1403255A4 (en) | 2001-06-12 | 2005-04-06 | Sumitomo Pharma | INHIBITORS OF RHO KINASE |
GB0117899D0 (en) | 2001-07-23 | 2001-09-12 | Astrazeneca Ab | Chemical compounds |
WO2003024450A1 (en) | 2001-09-20 | 2003-03-27 | Eisai Co., Ltd. | Methods for treating prion diseases |
SE0104340D0 (sv) | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New compounds |
CN100354264C (zh) * | 2002-07-22 | 2007-12-12 | 旭化成制药株式会社 | 5-取代异喹啉衍生物及含有它们的药物 |
EP1550660A1 (en) | 2002-09-12 | 2005-07-06 | Kirin Beer Kabushiki Kaisha | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same |
US20040266755A1 (en) | 2003-05-29 | 2004-12-30 | Schering Aktiengesellschaft | Prodrugs of 1-(1-hydroxy-5-isoquinolinesulfonyl) homopiperazine |
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EP1729761A4 (en) | 2004-03-05 | 2008-09-03 | Eisai Co Ltd | TREATMENT OF CADASIL WITH CHOLINESTERASE INHIBITORS |
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BRPI0613597A2 (pt) | 2005-06-28 | 2011-01-18 | Sanofi Aventis | derivado de isoquinolina como inibidores de rho-quinase |
BRPI0614063A2 (pt) * | 2005-07-26 | 2011-03-09 | Sanofi Aventis | derivados de cicloexilamina isoquinolona |
PT1910333E (pt) | 2005-07-26 | 2013-08-01 | Sanofi Sa | Derivados de isoquinolona substituída com piperidinilo como inibidores da rho-cinase |
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MY150746A (en) | 2006-12-27 | 2014-02-28 | Sanofi Aventis | Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase |
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KR20090092303A (ko) | 2006-12-27 | 2009-08-31 | 사노피-아벤티스 | 사이클로알킬아민 치환된 이소퀴놀린 유도체 |
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2009
- 2009-06-18 SI SI200930775T patent/SI2303845T1/sl unknown
- 2009-06-18 RU RU2011102460/04A patent/RU2532481C2/ru not_active IP Right Cessation
- 2009-06-18 BR BRPI0914330A patent/BRPI0914330A2/pt not_active IP Right Cessation
- 2009-06-18 US US13/000,202 patent/US8524737B2/en not_active Expired - Fee Related
- 2009-06-18 DK DK09768941.8T patent/DK2303845T3/da active
- 2009-06-18 ES ES09768941T patent/ES2434121T3/es active Active
- 2009-06-18 AU AU2009262509A patent/AU2009262509B2/en not_active Ceased
- 2009-06-18 NZ NZ590067A patent/NZ590067A/xx not_active IP Right Cessation
- 2009-06-18 EP EP09768941.8A patent/EP2303845B1/en active Active
- 2009-06-18 WO PCT/EP2009/004393 patent/WO2009156092A2/en active Application Filing
- 2009-06-18 CN CN200980124285.7A patent/CN102076667B/zh not_active Expired - Fee Related
- 2009-06-18 PT PT97689418T patent/PT2303845E/pt unknown
- 2009-06-18 PL PL09768941T patent/PL2303845T3/pl unknown
- 2009-06-18 MY MYPI2010005610A patent/MY153756A/en unknown
- 2009-06-18 JP JP2011515170A patent/JP5715561B2/ja not_active Expired - Fee Related
- 2009-06-18 CA CA2728123A patent/CA2728123C/en not_active Expired - Fee Related
- 2009-06-18 KR KR1020107028889A patent/KR101692211B1/ko active IP Right Grant
- 2009-06-18 MX MX2010013867A patent/MX2010013867A/es active IP Right Grant
- 2009-06-22 UY UY0001031924A patent/UY31924A/es not_active Application Discontinuation
- 2009-06-22 AR ARP090102283A patent/AR072279A1/es unknown
- 2009-06-22 TW TW98120765A patent/TWI466868B/zh not_active IP Right Cessation
-
2010
- 2010-11-12 ZA ZA2010/08120A patent/ZA201008120B/en unknown
- 2010-12-17 MA MA33439A patent/MA32401B1/fr unknown
- 2010-12-20 IL IL210114A patent/IL210114A/en not_active IP Right Cessation
- 2010-12-21 CO CO10160337A patent/CO6321251A2/es not_active Application Discontinuation
-
2011
- 2011-06-22 HK HK11106455.2A patent/HK1152308A1/xx not_active IP Right Cessation
-
2013
- 2013-11-05 HR HRP20131040AT patent/HRP20131040T1/hr unknown
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