DK2285364T3 - Terapeutisk regenerering og berigelse af okulær overfladesmøring - Google Patents

Terapeutisk regenerering og berigelse af okulær overfladesmøring Download PDF

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Publication number
DK2285364T3
DK2285364T3 DK09743204.1T DK09743204T DK2285364T3 DK 2285364 T3 DK2285364 T3 DK 2285364T3 DK 09743204 T DK09743204 T DK 09743204T DK 2285364 T3 DK2285364 T3 DK 2285364T3
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pharmaceutical composition
prg4
eye
use according
protein
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DK09743204.1T
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English (en)
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Benjamin Sullivan
Tannin A Schmidt
David A Sullivan
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Univ California
Schepens Eye Res Inst
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/688—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Eyeglasses (AREA)
  • Materials For Medical Uses (AREA)

Claims (12)

1. Farmaceutisk sammensætning til anvendelse i behandlingen af vandig eller evaporativ tørt øje sygdom, en tilstand som er associeret med eller som forårsager vandig eller evaporativ tørt øje sygdom, eller symptomer associerede dermed hos et individ, hvor sammensætningen er egnet til topisk anvendelse på en okulær overflade, og omfattende en terapeutisk effektiv koncentration af PRG4 opslæmmet i en for øjnene acceptabel balanceret saltopløsning.
2. Farmaceutisk sammensætning til anvendelse ifølge krav 1, omfattende et eller flere for øjnene acceptable stoffer valgt fra gruppen bestående af et for øjnene acceptabelt lindrende middel, en for øjnene acceptabel excipient, et for øjnene acceptabelt sammensnerpende middel, et for øjnene acceptabelt karforsnævrende middel, en for øjnene acceptabel elektrolyt, en for øjnene acceptabel natriumhyaluronat eller hyaluronsyre, et for øjnene acceptabelt overfladeaktivt phospholipid, og et for øjnene acceptabelt blødgøringsmiddel.
3. Farmaceutisk sammensætning til anvendelse ifølge krav 1 eller 2, hvor den farmaceutiske sammensætning omfatter PRG4 i den terapeutisk effektive koncentration på 10-10.000 pg/mL.
4. Farmaceutisk sammensætning til anvendelse ifølge krav 1 eller 2, hvor den farmaceutiske sammensætning omfatter PRG4 i den terapeutisk effektive koncentration på 50-500 pg/mL.
5. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af kravene 1 til 3, endvidere omfattende en terapeutisk effektiv koncentration af natriumhyaluronat eller hyaluronsyre.
6. Farmaceutisk sammensætning til anvendelse ifølge krav 5, hvor den farmaceutiske sammensætning omfatter natriumhyaluronat eller hyaluronsyre i den terapeutisk effektive koncentration på 10-100.000 pg/mL.
7. Farmaceutisk sammensætning til anvendelse ifølge krav 5, hvor den farmaceutiske sammensætning omfatter natriumhyaluronat eller hyaluronsyre i den terapeutisk effektive koncentration på 500-5.000 pg/mL.
8. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af kravene 1 til 7, endvidere omfattende en terapeutisk effektiv koncentration af overfladeaktivt phospholipid valgt fra gruppen bestående af L-a-dipalmitoylphosphatidylcholin, phosphatidylcholin, phosphatidylethanolamin og sphingomyelin.
9. Farmaceutisk sammensætning til anvendelse ifølge krav 8, hvor den farmaceutiske sammensætning omfatter det overfladeaktive phospholipid i den terapeutisk effektive koncentration på 10-10.000 pg/mL.
10. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af kravene 1 til 9, hvor den for øjnene acceptable balancerede saltopløsning omfatter mindst tre forskellige elektrolytter valgt fra gruppen bestående af natriumfosfat, natriumklorid, kaliumklorid, natriumbikarbonat, kaliumbikarbonat, calciumklorid, magnesiumklorid, natriumacetat, natriumcitrat, saltsyre, og natriumhydroxid.
11. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af kravene 1 til 10, hvor PRG4 er et oprenset naturligt forekommende eller rekombinant PRG4-protein omfattende et smørefragment, en multimer eller en homolog deraf, med en gennemsnitlig molmasse mellem 50 kDa og 400 kDa.
12. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af kravene 1 til 11, hvor den farmaceutiske sammensætning omfatter PRG4 i den terapeutisk effektive koncentration på 100-300 pg/mL.
DK09743204.1T 2008-05-07 2009-04-08 Terapeutisk regenerering og berigelse af okulær overfladesmøring DK2285364T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5111208P 2008-05-07 2008-05-07
PCT/US2009/039887 WO2009137217A2 (en) 2008-05-07 2009-04-08 Therapeutic replenishment and enrichment of ocular surface lubrication

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DK2285364T3 true DK2285364T3 (da) 2015-02-16

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DK09743204.1T DK2285364T3 (da) 2008-05-07 2009-04-08 Terapeutisk regenerering og berigelse af okulær overfladesmøring
DK15151634.1T DK2915529T3 (da) 2008-05-07 2009-04-08 Terapeutisk regenerering og berigelse af okulær overfladesmøring
DK09743588.7T DK2276496T3 (da) 2008-05-07 2009-05-06 Terapeutisk modulering af øjenoverfladebefugtning

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DK15151634.1T DK2915529T3 (da) 2008-05-07 2009-04-08 Terapeutisk regenerering og berigelse af okulær overfladesmøring
DK09743588.7T DK2276496T3 (da) 2008-05-07 2009-05-06 Terapeutisk modulering af øjenoverfladebefugtning

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US (9) US9393285B2 (da)
EP (4) EP2915529B1 (da)
JP (3) JP5508398B2 (da)
CN (2) CN105664136A (da)
CA (3) CA2722913C (da)
CY (2) CY1119122T1 (da)
DK (3) DK2285364T3 (da)
ES (3) ES2633792T3 (da)
HR (3) HRP20150097T1 (da)
HU (2) HUE024146T2 (da)
LT (2) LT2915529T (da)
PL (3) PL2915529T3 (da)
PT (2) PT2285364E (da)
RU (1) RU2510274C2 (da)
SI (3) SI2915529T1 (da)
WO (3) WO2009137217A2 (da)

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