DK2278030T3 - Fremgangsmåder til undersøgelse og genetisk analyse af populationer - Google Patents

Fremgangsmåder til undersøgelse og genetisk analyse af populationer Download PDF

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DK2278030T3
DK2278030T3 DK10012384.3T DK10012384T DK2278030T3 DK 2278030 T3 DK2278030 T3 DK 2278030T3 DK 10012384 T DK10012384 T DK 10012384T DK 2278030 T3 DK2278030 T3 DK 2278030T3
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dna
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unknown
marker
rrna
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DK10012384.3T
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Matthew Ashby
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Taxon Biosciences Inc
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6813—Hybridisation assays
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/40—Population genetics; Linkage disequilibrium
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q2600/156—Polymorphic or mutational markers
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    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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Claims (12)

1. Fremgangsmåde til konstruktion af en markørdiversitetsprofil- (MDP) database, hvilken fremgangsmåde omfatter følgende trin: a) sekvensering af en flerhed af rRNA-markører fra en prøve, hvor prøver omfatter en mikrobiel population, og hvor hver rRNA-markør omfatter et mikrobielt rRNA-gens polymorfe sekvens, og hvor flerheden af rRNA-markører tilvejebringer en præcis repræsentation af prøvens mikrobielle struktur; b) bestemmelse af abundansen, i prøven, af hver af flerheden af rRNA-markører; c) transduktion af abundansen af hver rRNA-markør til et elektrisk udgangssignal; d) lagring af de elektriske udgangssignaler frembragt i trin c) i en matrixdatastruktur og associering i strukturen af hvert udgangssignal med den tilsvarende sekvens af rRNA-markøren, hvorfra abundansudgangssignalet var transduceret; e) tilvejebringelse af abundanser af ét eller flere prøveparametre, der er forbundet med prøven; f) transduktion af abundanseme af hvert prøveparameter til et elektrisk udgangssignal; g) lagring af de elektriske udgangssignaler frembragt i trin f) i en matrixdatastruktur og associering i strukturen af hvert udgangssignal med prøveparameteret, hvorfra abundansudgangssignalet var transduceret; h) betegnelse af de elektriske udgangssignaler frembragt i trin c) svarende til flerheden af rRNA-markørabundanser og de elektriske udgangssignaler frembragt i trin f) svarende til den ene eller flere prøveparameterabundanser, som en MDP; og i) gentagelse af trin a-h for en flerhed af andre prøver, og betegnelse af flerheden af MDP’er laget i datastrukturen som en MDP-database.
2. Fremgangsmåde ifølge krav 1, hvor rRNA-markørabundansen er en abundans i forhold til den totale abundans af flerheden af rRNA-markører i prøven.
3. Fremgangsmåde ifølge krav 1 eller 2, hvor det mikrobielle rRNA-gen er et 16S Rrna-gen.
4. Fremgangsmåde ifølge krav 1 eller 2, hvor det mikrobielle rRNA-gens polymorfe sekvens er fra intergen-området mellem et 16S rRNA-gen og et 23S rRNA-gen.
5. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 4, hvor prøven er udvalgt fra gruppen bestående af: en jordprøve, en klippeprøve, en vandprøve, en luftprøve, en carbonhydridprøve, en petroleumsprøve og en biofilmprøve.
6. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 5, hvor prøven er opnået fra gmppen bestående af: petroleum, carbonhydrider, et oliereservoir, et gasreservoir, jord, klippe, vand, luft, en bygning og en vej.
7. Fremgangsmåde ifølge krav 6, hvor prøveparameteret er udvalgt fra gruppen bestående af: petroleum, carbonhydrider, olie, gas, en uorganisk forbindelse, et mineral, pH, temperatur og saltholdighed.
8. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 4, hvor prøven er opnået fra gruppen bestående af: et menneske, en plante, et dyr, en fødevare, en cellekultur eller en vævskultur.
9. Fremgangsmåde ifølge krav 8, hvor prøveparameteret er udvalgt fra gmppen bestående af: en akut sygdomstilstand, en kronisk sygdomstilstand, en fysiologisk tilstand og et udviklingstrin.
10. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 4, hvor prøveparameteret er tid, og hvor flerheden af prøver omfatter et tidsforløb.
11. Fremgangsmåde ifølge krav 10, hvor flerheden af prøver omfatter et tidsforløb, der kan anvendes til overvågning af miljømæssige afhjælpningsforanstaltninger eller oliefeltsproduktion.
12. MDP-database, der er opbygget og lagret i hukommelsen på en computer ifølge fremgangsmåden ifølge et hvilket som helst af kravene 1 til 11.
DK10012384.3T 2000-04-10 2001-04-10 Fremgangsmåder til undersøgelse og genetisk analyse af populationer DK2278030T3 (da)

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US19606300P 2000-04-10 2000-04-10
US19625800P 2000-04-11 2000-04-11
EP10152284.5A EP2206791B1 (en) 2000-04-10 2001-04-10 Methods for the survey and genetic analysis of populations

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Families Citing this family (208)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110166040A1 (en) * 1997-09-05 2011-07-07 Ibis Biosciences, Inc. Compositions for use in identification of strains of e. coli o157:h7
DK2278029T3 (da) 2000-04-10 2016-10-03 Taxon Biosciences Inc Fremgangsmåder til undersøgelse og genetisk analyse af populationer
WO2002010438A2 (en) * 2000-07-28 2002-02-07 The Johns Hopkins University Serial analysis of transcript expression using long tags
US7054828B2 (en) * 2000-12-20 2006-05-30 International Business Machines Corporation Computer method for using sample data to predict future population and domain behaviors
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US20040121313A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in organs for transplantation
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US7718354B2 (en) 2001-03-02 2010-05-18 Ibis Biosciences, Inc. Methods for rapid identification of pathogens in humans and animals
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
AU2003208480A1 (en) * 2002-03-05 2003-09-16 Lynx Therapeutics INC. Methods for detecting genome-wide sequence variations associated with a phenotype
US7323306B2 (en) * 2002-04-01 2008-01-29 Brookhaven Science Associates, Llc Genome signature tags
US7135310B2 (en) * 2002-04-24 2006-11-14 The Regents Of The University Of California Method to amplify variable sequences without imposing primer sequences
US8048623B1 (en) 2002-04-24 2011-11-01 The University Of North Carolina At Greensboro Compositions, products, methods and systems to monitor water and other ecosystems
US8383342B2 (en) 2002-04-24 2013-02-26 The University Of North Carolina At Greensboro Compositions, products, methods and systems to monitor water and other ecosystems
US9126165B1 (en) 2002-04-24 2015-09-08 The University Of North Carolina At Greensboro Nucleic acid arrays to monitor water and other ecosystems
US20040161767A1 (en) * 2002-06-28 2004-08-19 Baldwin Brett R. Detection and quantification of aromatic oxygenase genes by real-time PCR
GB0220798D0 (en) * 2002-09-06 2002-10-16 Statoil Asa Identification tool for hydrocarbon zones
EP1578399A4 (en) 2002-12-06 2007-11-28 Isis Pharmaceuticals Inc METHODS FOR RAPID IDENTIFICATION OF PATHOGENS IN HUMANS AND BEETS
NL1022152C2 (nl) * 2002-12-12 2004-06-18 Tno Procescontrole gebaseerd op analyse van microbiele populaties.
US20040177011A1 (en) * 2003-03-06 2004-09-09 Ramsay Jimmie A. Food contamination tracking system
WO2004090164A2 (en) * 2003-04-14 2004-10-21 Stichting Voor De Technische Wetenschappen Method for determining soil condition
US8046171B2 (en) 2003-04-18 2011-10-25 Ibis Biosciences, Inc. Methods and apparatus for genetic evaluation
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US20050026188A1 (en) * 2003-05-30 2005-02-03 Van Kessel Andrew G. Methods of identifying, characterizing and comparing organism communities
US7205111B2 (en) * 2003-07-24 2007-04-17 Marshfield Clinic Rapid identification of bacteria from positive blood cultures
US20100129811A1 (en) * 2003-09-11 2010-05-27 Ibis Biosciences, Inc. Compositions for use in identification of pseudomonas aeruginosa
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8242254B2 (en) 2003-09-11 2012-08-14 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8222005B2 (en) * 2003-09-17 2012-07-17 Agency For Science, Technology And Research Method for gene identification signature (GIS) analysis
US8163895B2 (en) 2003-12-05 2012-04-24 Ibis Biosciences, Inc. Compositions for use in identification of orthopoxviruses
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
US8119336B2 (en) 2004-03-03 2012-02-21 Ibis Biosciences, Inc. Compositions for use in identification of alphaviruses
WO2005117270A2 (en) 2004-05-24 2005-12-08 Isis Pharmaceuticals, Inc. Mass spectrometry with selective ion filtration by digital thresholding
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
CA2600184A1 (en) 2005-03-03 2006-09-08 Isis Pharmaceuticals, Inc. Compositions for use in identification of adventitious viruses
US8445194B2 (en) 2005-06-15 2013-05-21 Callida Genomics, Inc. Single molecule arrays for genetic and chemical analysis
AU2006272776B2 (en) 2005-07-21 2012-01-19 Ibis Biosciences, Inc. Methods for rapid identification and quantitation of nucleic acid variants
GB0525523D0 (en) * 2005-12-15 2006-01-25 Macaulay Land Use Res Inst Genetic process
US8088582B2 (en) 2006-04-06 2012-01-03 Ibis Biosciences, Inc. Compositions for the use in identification of fungi
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US9074242B2 (en) 2010-02-12 2015-07-07 Raindance Technologies, Inc. Digital analyte analysis
EP2481815B1 (en) 2006-05-11 2016-01-27 Raindance Technologies, Inc. Microfluidic devices
US20080124707A1 (en) * 2006-06-09 2008-05-29 Agency For Science, Technology And Research Nucleic acid concatenation
AU2007353877B2 (en) 2006-09-14 2012-07-19 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
DK2099935T3 (da) * 2006-11-30 2014-04-07 Univ California Array for detektion af mikrober
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
EP2126132B1 (en) 2007-02-23 2013-03-20 Ibis Biosciences, Inc. Methods for rapid foresnsic dna analysis
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US20080281819A1 (en) * 2007-05-10 2008-11-13 The Research Foundation Of State University Of New York Non-random control data set generation for facilitating genomic data processing
WO2009023358A2 (en) * 2007-05-25 2009-02-19 Ibis Biosciences, Inc. Compositions for use in identification of strains of hepatitis c virus
WO2008151023A2 (en) 2007-06-01 2008-12-11 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
US20110045456A1 (en) * 2007-06-14 2011-02-24 Ibis Biosciences, Inc. Compositions for use in identification of adventitious contaminant viruses
GB2451287A (en) * 2007-07-26 2009-01-28 Envirogene Ltd Identification of hydrocarbon deposits through detection of a microbial polynucleotide
US8592150B2 (en) 2007-12-05 2013-11-26 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing
US20110097704A1 (en) * 2008-01-29 2011-04-28 Ibis Biosciences, Inc. Compositions for use in identification of picornaviruses
US9074244B2 (en) 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
US20110177515A1 (en) * 2008-05-30 2011-07-21 Ibis Biosciences, Inc. Compositions for use in identification of francisella
US20110151437A1 (en) * 2008-06-02 2011-06-23 Ibis Biosciences, Inc. Compositions for use in identification of adventitious viruses
EP2315629B1 (en) 2008-07-18 2021-12-15 Bio-Rad Laboratories, Inc. Droplet libraries
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
CA2735250A1 (en) * 2008-07-30 2010-02-04 Nippon Steel Kankyo Engineering Co., Ltd. Universal nucleic acid probe set and method for utilization thereof
US8148163B2 (en) 2008-09-16 2012-04-03 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
EP2344893B1 (en) 2008-09-16 2014-10-15 Ibis Biosciences, Inc. Microplate handling systems and methods
EP2349549B1 (en) 2008-09-16 2012-07-18 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, and system
US20110200985A1 (en) * 2008-10-02 2011-08-18 Rangarajan Sampath Compositions for use in identification of herpesviruses
US20110189687A1 (en) * 2008-10-02 2011-08-04 Ibis Bioscience, Inc. Compositions for use in identification of members of the bacterial genus mycoplasma
US20110183346A1 (en) * 2008-10-03 2011-07-28 Ibis Biosciences, Inc. Compositions for use in identification of neisseria, chlamydia, and/or chlamydophila bacteria
US20110183345A1 (en) * 2008-10-03 2011-07-28 Ibis Biosciences, Inc. Compositions for use in identification of streptococcus pneumoniae
WO2010039775A1 (en) * 2008-10-03 2010-04-08 Ibis Biosciences, Inc. Compositions for use in identification of members of the bacterial class alphaproteobacter
US20110183344A1 (en) * 2008-10-03 2011-07-28 Rangarajan Sampath Compositions for use in identification of clostridium difficile
US20110190170A1 (en) * 2008-10-03 2011-08-04 Ibis Biosciences, Inc. Compositions for use in identification of antibiotic-resistant bacteria
EP2396803A4 (en) 2009-02-12 2016-10-26 Ibis Biosciences Inc IONIZATION PROBE ASSEMBLIES
US9719083B2 (en) 2009-03-08 2017-08-01 Ibis Biosciences, Inc. Bioagent detection methods
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
WO2011008971A1 (en) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Lift and mount apparatus
US9194877B2 (en) 2009-07-17 2015-11-24 Ibis Biosciences, Inc. Systems for bioagent indentification
US9416409B2 (en) 2009-07-31 2016-08-16 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
EP3098325A1 (en) 2009-08-06 2016-11-30 Ibis Biosciences, Inc. Non-mass determined base compositions for nucleic acid detection
US20110065111A1 (en) * 2009-08-31 2011-03-17 Ibis Biosciences, Inc. Compositions For Use In Genotyping Of Klebsiella Pneumoniae
EP2488656B1 (en) 2009-10-15 2015-06-03 Ibis Biosciences, Inc. Multiple displacement amplification
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
WO2011115840A2 (en) * 2010-03-14 2011-09-22 Ibis Biosciences, Inc. Parasite detection via endosymbiont detection
US10221432B2 (en) 2010-06-16 2019-03-05 Conocophillips Company In situ methanogenesis modeling and risk analysis
WO2012016215A2 (en) * 2010-07-30 2012-02-02 Taxon Biosciences, Inc. Microbial bioindicators of hydrocarbons in water and in marine sediments and methods for making and using them
EP2614160B1 (en) 2010-09-10 2016-04-06 Bio-Rad Laboratories, Inc. Detection of rna-interacting regions in dna
WO2012051504A2 (en) 2010-10-14 2012-04-19 Rheonix, Inc. Quantitative multiplexed identification of nucleic acid targets
WO2012112606A1 (en) 2011-02-15 2012-08-23 Bio-Rad Laboratories, Inc. Detecting methylati0n in a subpopulation of genomic dna
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
US9556470B2 (en) 2011-06-02 2017-01-31 Raindance Technologies, Inc. Enzyme quantification
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
CN104039978A (zh) * 2011-09-29 2014-09-10 露美内克丝公司 水解探针
CA2853286C (en) 2011-11-11 2019-01-08 Exxonmobil Upstream Research Company Exploration method and system for detection of hydrocarbons with an underwater vehicle
BR112014007819B1 (pt) 2011-11-11 2021-03-02 Exxonmobil Upstream Research Company método para produzir hidrocarbonetos
CN102492022B (zh) * 2011-12-08 2013-05-29 重庆大学 一种新型抗老年痴呆症先导化合物
WO2013119350A1 (en) * 2012-02-06 2013-08-15 Exxonmobil Upstream Research Company Method to determine location, size and in situ conditions in hydrocarbon reservoir with ecology, geochemistry, and biomarkers
EP2823303A4 (en) * 2012-02-10 2015-09-30 Raindance Technologies Inc MOLECULAR DIAGNOSTIC SCREEN TYPE ASSAY
GB2513024B (en) 2012-02-27 2016-08-31 Cellular Res Inc A clonal amplification method
KR102018934B1 (ko) * 2012-02-27 2019-09-06 도레이 카부시키가이샤 핵산의 검출 방법
EP2694669B1 (en) 2012-06-28 2017-05-17 Taxon Biosciences, Inc. Methods for making or creating a synthetic microbial consortium identified by computational analysis of amplicon sequences
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
CN113528634A (zh) 2012-08-14 2021-10-22 10X基因组学有限公司 微胶囊组合物及方法
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP3567116A1 (en) 2012-12-14 2019-11-13 10X Genomics, Inc. Methods and systems for processing polynucleotides
KR102190198B1 (ko) 2013-02-08 2020-12-14 10엑스 제노믹스, 인크. 폴리뉴클레오티드 바코드 생성
US20140272959A1 (en) * 2013-03-14 2014-09-18 President And Fellows Of Harvard College Methods of Hybridizing Probes to Genomic DNA
GB2525104B (en) 2013-08-28 2016-09-28 Cellular Res Inc Massively Parallel Single Cell Nucleic Acid Analysis
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
JP2017504307A (ja) 2013-10-07 2017-02-09 セルラー リサーチ， インコーポレイテッド アレイ上のフィーチャーをデジタルカウントするための方法およびシステム
EP3074537A4 (en) * 2013-11-26 2017-07-26 Bio-rad Laboratories, Inc. Methods for detecting nucleic acid proximity
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
CA2937226C (en) 2014-03-07 2020-04-21 Exxonmobil Upstream Research Company Exploration method and system for detection of hydrocarbons from the water column
WO2015147370A1 (en) * 2014-03-28 2015-10-01 Seegene, Inc. Detection of target nucleic acid sequences using different detection temperatures
EP3792366A1 (en) * 2014-04-04 2021-03-17 Affymetrix, Inc. Improved compositions and methods for molecular inversion probe assays
WO2015157567A1 (en) 2014-04-10 2015-10-15 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
EP3161160B1 (en) 2014-06-26 2021-10-13 10X Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
WO2016012508A1 (en) * 2014-07-23 2016-01-28 Steffen Mergemeier Method for the detection of sepsis
GB201413718D0 (en) * 2014-08-01 2014-09-17 Olink Ab Method for selecting a target nucleic acid sequence
WO2016043981A1 (en) 2014-09-18 2016-03-24 Exxonmobil Upstream Research Company Method to enhance exploration, development and production of hydrocarbons using multiply substituted isotopologue geochemistry, basin modeling and molecular kinetics
US10400596B2 (en) 2014-09-18 2019-09-03 Exxonmobil Upstream Research Company Method to enhance exploration, development and production of hydrocarbons using multiply substituted isotopologue geochemistry, basin modeling and molecular kinetics
US9890617B2 (en) 2014-09-18 2018-02-13 Exxonmobil Upstream Research Company Method to determine the presence of source rocks and the timing and extent of hydrocarbon generation for exploration, production and development of hydrocarbons
US10494923B2 (en) 2014-09-18 2019-12-03 Exxonmobil Upstream Research Company Method to perform hydrocarbon system analysis for exploration, production and development of hydrocarbons
CA2961727A1 (en) 2014-09-19 2016-03-24 Taxon Biosciences Inc Plant growth-promoting microbes, compositions, and uses
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
SG11201705615UA (en) 2015-01-12 2017-08-30 10X Genomics Inc Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
WO2016123419A1 (en) * 2015-01-30 2016-08-04 President And Fellows Of Harvard College Microscope-free imaging
WO2016126397A1 (en) 2015-02-03 2016-08-11 Exxonmobil Upstream Research Company Applications of advanced isotope geochemistry of hydrocarbons and inert gases to petroleum production engineering
EP3254100B1 (en) 2015-02-03 2020-02-19 Exxonmobil Upstream Research Company Applications of advanced isotope geochemistry of hydrocarbons and inert gases to petroleum production engineering
EP3259371B1 (en) 2015-02-19 2020-09-02 Becton, Dickinson and Company High-throughput single-cell analysis combining proteomic and genomic information
EP4286516A3 (en) 2015-02-24 2024-03-06 10X Genomics, Inc. Partition processing methods and systems
WO2016138496A1 (en) 2015-02-27 2016-09-01 Cellular Research, Inc. Spatially addressable molecular barcoding
WO2016140826A1 (en) 2015-03-02 2016-09-09 Exxonmobil Upstream Research Company Field deployable system to measure clumped isotopes
US11535882B2 (en) 2015-03-30 2022-12-27 Becton, Dickinson And Company Methods and compositions for combinatorial barcoding
US20160299129A1 (en) * 2015-04-07 2016-10-13 Xiaolei Qiu Ultra Sensitive and Specific Multiplex Biosensor System Based on Multiple Cooperative Interactions
WO2016172373A1 (en) * 2015-04-23 2016-10-27 Cellular Research, Inc. Methods and compositions for whole transcriptome amplification
US11124823B2 (en) 2015-06-01 2021-09-21 Becton, Dickinson And Company Methods for RNA quantification
US9938558B2 (en) 2015-06-25 2018-04-10 Ascus Biosciences, Inc. Methods, apparatuses, and systems for analyzing microorganism strains from complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
US10851399B2 (en) 2015-06-25 2020-12-01 Native Microbials, Inc. Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
EP3314007B1 (en) 2015-06-25 2024-01-24 Native Microbials, Inc. Methods, apparatuses, and systems for analyzing microorganism strains from complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
WO2018126026A1 (en) 2016-12-28 2018-07-05 Ascus Biosciences, Inc. Methods, apparatuses, and systems for analyzing complete microorganism strains in complex heterogeneous communities, determining functional relationships and interactions thereof, and identifying and synthesizing bioreactive modificators based thereon
EP3130673B1 (en) * 2015-08-13 2019-06-12 Centrillion Technology Holdings Corporation Library construction using y-adapters and vanishing restriction sites
EP3347465B1 (en) 2015-09-11 2019-06-26 Cellular Research, Inc. Methods and compositions for nucleic acid library normalization
US11371094B2 (en) 2015-11-19 2022-06-28 10X Genomics, Inc. Systems and methods for nucleic acid processing using degenerate nucleotides
CN114774529A (zh) * 2015-11-19 2022-07-22 10X基因组学有限公司 可转化标记组合物、方法及结合其的过程
JP6703824B2 (ja) * 2015-11-30 2020-06-03 シスメックス株式会社 細胞選択方法、細胞検出方法、細胞選択装置、および細胞検出装置
CN108431232B (zh) 2015-12-04 2022-10-14 10X 基因组学有限公司 用于核酸分析的方法和组合物
EP3400285A4 (en) 2016-01-07 2019-09-18 Ascus Biosciences, Inc. METHOD FOR IMPROVING MILK PRODUCTION BY ADMINISTERING MICROBIAL CONSORTIA
EP3452614B1 (en) 2016-05-02 2023-06-28 Becton, Dickinson and Company Accurate molecular barcoding
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
WO2017205691A1 (en) 2016-05-26 2017-11-30 Cellular Research, Inc. Molecular label counting adjustment methods
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
WO2017209990A1 (en) 2016-05-31 2017-12-07 Exxonmobil Upstream Research Company METHODS FOR lSOLATING NUCLEIC ACIDS FROM SAMPLES
CN107507823B (zh) * 2016-06-14 2022-12-20 三星电子株式会社 半导体封装和用于制造半导体封装的方法
US10895666B2 (en) 2016-07-01 2021-01-19 Exxonmobil Upstream Research Company Methods for identifying hydrocarbon reservoirs
US10132144B2 (en) 2016-09-02 2018-11-20 Exxonmobil Upstream Research Company Geochemical methods for monitoring and evaluating microbial enhanced recovery operations
EP3516079B1 (en) 2016-09-20 2022-06-22 President and Fellows of Harvard College Molecular product authentication systems
CA3034924A1 (en) 2016-09-26 2018-03-29 Cellular Research, Inc. Measurement of protein expression using reagents with barcoded oligonucleotide sequences
US11015154B2 (en) 2016-11-09 2021-05-25 The Regents Of The University Of California Methods for identifying interactions amongst microorganisms
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
CN110352250A (zh) 2016-12-28 2019-10-18 埃斯库斯生物科技股份公司 用于通过示踪剂分析法对复杂异质群落进行微生物株系分析、确定其功能关系及相互作用以及合成包括给药微生物群集和接种微生物群集的微生物群集的方法、设备和系统
WO2018132610A1 (en) 2017-01-13 2018-07-19 Cellular Research, Inc. Hydrophilic coating of fluidic channels
CN117512066A (zh) 2017-01-30 2024-02-06 10X基因组学有限公司 用于基于微滴的单细胞条形编码的方法和系统
US11319583B2 (en) 2017-02-01 2022-05-03 Becton, Dickinson And Company Selective amplification using blocking oligonucleotides
UY37708A (es) 2017-04-28 2018-10-31 Ascus Biosciences Inc Métodos para complementar dietas con alto consumo de granos y/o alto valor energético en rumiantes, mediante la administración de un bioensamble sintético de microbios, o cepas purificadas de los mismos
CN109526228B (zh) 2017-05-26 2022-11-25 10X基因组学有限公司 转座酶可接近性染色质的单细胞分析
US10400235B2 (en) 2017-05-26 2019-09-03 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
AU2018281745B2 (en) 2017-06-05 2022-05-19 Becton, Dickinson And Company Sample indexing for single cells
EP3625361A1 (en) 2017-11-15 2020-03-25 10X Genomics, Inc. Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
WO2019126209A1 (en) 2017-12-19 2019-06-27 Cellular Research, Inc. Particles associated with oligonucleotides
WO2019195166A1 (en) 2018-04-06 2019-10-10 10X Genomics, Inc. Systems and methods for quality control in single cell processing
WO2019213237A1 (en) 2018-05-03 2019-11-07 Becton, Dickinson And Company Molecular barcoding on opposite transcript ends
US11773441B2 (en) 2018-05-03 2023-10-03 Becton, Dickinson And Company High throughput multiomics sample analysis
US11649478B2 (en) * 2018-05-21 2023-05-16 ExxonMobil Technology and Engineering Company Identification of hot environments using biomarkers from cold-shock proteins of thermophilic and hyperthermophilic microorganisms
CN108866170A (zh) * 2018-07-13 2018-11-23 北京出入境检验检疫局检验检疫技术中心 一种基于pcr-dgge技术的沙门氏菌分型方法
WO2020072380A1 (en) 2018-10-01 2020-04-09 Cellular Research, Inc. Determining 5' transcript sequences
US11932849B2 (en) 2018-11-08 2024-03-19 Becton, Dickinson And Company Whole transcriptome analysis of single cells using random priming
CN113195717A (zh) 2018-12-13 2021-07-30 贝克顿迪金森公司 单细胞全转录组分析中的选择性延伸
US11371076B2 (en) 2019-01-16 2022-06-28 Becton, Dickinson And Company Polymerase chain reaction normalization through primer titration
ES2945227T3 (es) 2019-01-23 2023-06-29 Becton Dickinson Co Oligonucleótidos asociados con anticuerpos
US12071617B2 (en) 2019-02-14 2024-08-27 Becton, Dickinson And Company Hybrid targeted and whole transcriptome amplification
US11965208B2 (en) 2019-04-19 2024-04-23 Becton, Dickinson And Company Methods of associating phenotypical data and single cell sequencing data
CN114051534A (zh) 2019-07-22 2022-02-15 贝克顿迪金森公司 单细胞染色质免疫沉淀测序测定
JP7522189B2 (ja) 2019-11-08 2024-07-24 ベクトン・ディキンソン・アンド・カンパニー 免疫レパートリーシーケンシングのための完全長ｖ（ｄ）ｊ情報を得るためのランダムプライミングの使用
EP4090763A1 (en) 2020-01-13 2022-11-23 Becton Dickinson and Company Methods and compositions for quantitation of proteins and rna
EP4150118A1 (en) 2020-05-14 2023-03-22 Becton Dickinson and Company Primers for immune repertoire profiling
CN111705141B (zh) * 2020-06-29 2023-04-28 福州海关技术中心 一种荧光定量pcr检测鉴定乳状耳形螺的方法
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
WO2022047328A1 (en) * 2020-08-31 2022-03-03 Applied Materials, Inc. Slides for calibration of mfish
EP4247967A1 (en) 2020-11-20 2023-09-27 Becton, Dickinson and Company Profiling of highly expressed and lowly expressed proteins
US11668847B2 (en) 2021-01-04 2023-06-06 Saudi Arabian Oil Company Generating synthetic geological formation images based on rock fragment images
CN114015794B (zh) * 2022-01-06 2022-03-25 山东省中地易采石油技术有限责任公司 一种基于地质微生物群落特征的产液剖面图的构建方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055397A (en) 1987-12-17 1991-10-08 Atlantic Richfield Company Geomicrobiological methods of ore and petroleum exploration
US5093236A (en) * 1988-09-14 1992-03-03 Genecor International, Inc. Microbiological oil prospecting
US5700636A (en) * 1990-10-19 1997-12-23 Becton Dickinson And Company Methods for selectively detecting microorganisms associated with vaginal infections in complex biological samples
US5866330A (en) 1995-09-12 1999-02-02 The Johns Hopkins University School Of Medicine Method for serial analysis of gene expression
US5695937A (en) 1995-09-12 1997-12-09 The Johns Hopkins University School Of Medicine Method for serial analysis of gene expression
US5981190A (en) * 1997-01-08 1999-11-09 Ontogeny, Inc. Analysis of gene expression, methods and reagents therefor
DK2278029T3 (da) 2000-04-10 2016-10-03 Taxon Biosciences Inc Fremgangsmåder til undersøgelse og genetisk analyse af populationer

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