DK2267451T3 - Todimensionalt spektralt billedsystem og fremgangsmåde - Google Patents

Todimensionalt spektralt billedsystem og fremgangsmåde Download PDF

Info

Publication number
DK2267451T3
DK2267451T3 DK10180073.8T DK10180073T DK2267451T3 DK 2267451 T3 DK2267451 T3 DK 2267451T3 DK 10180073 T DK10180073 T DK 10180073T DK 2267451 T3 DK2267451 T3 DK 2267451T3
Authority
DK
Denmark
Prior art keywords
spectra
detection region
identifiable
probes
labels
Prior art date
Application number
DK10180073.8T
Other languages
English (en)
Inventor
Stephen A Empedocles
Joseph A Treadway
Andrew R Watson
Original Assignee
Life Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Life Technologies Corp filed Critical Life Technologies Corp
Application granted granted Critical
Publication of DK2267451T3 publication Critical patent/DK2267451T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/272—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration for following a reaction, e.g. for determining photometrically a reaction rate (photometric cinetic analysis)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G01N21/278—Constitution of standards
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6489—Photoluminescence of semiconductors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00427—Means for dispensing and evacuation of reagents using masks
    • B01J2219/00432—Photolithographic masks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00574—Chemical means radioactive
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00578—Chemical means electrophoric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00657—One-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00677—Ex-situ synthesis followed by deposition on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • B01J2219/00743—Cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0454—Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/54—Labware with identification means
    • B01L3/545—Labware with identification means for laboratory containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N2015/0092—Monitoring flocculation or agglomeration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • G01N2015/1472—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle with colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1497—Particle shape
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6482—Sample cells, cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742—Type of codes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742—Type of codes
    • G01N2035/00752—Type of codes bar codes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/04—Batch operation; multisample devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
DK10180073.8T 2000-04-06 2001-04-06 Todimensionalt spektralt billedsystem og fremgangsmåde DK2267451T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19552000P 2000-04-06 2000-04-06
EP01928376A EP1282734B1 (en) 2000-04-06 2001-04-06 Differentiable spectral bar code methods and systems

Publications (1)

Publication Number Publication Date
DK2267451T3 true DK2267451T3 (da) 2016-05-17

Family

ID=22721719

Family Applications (1)

Application Number Title Priority Date Filing Date
DK10180073.8T DK2267451T3 (da) 2000-04-06 2001-04-06 Todimensionalt spektralt billedsystem og fremgangsmåde

Country Status (9)

Country Link
US (12) US6734420B2 (da)
EP (4) EP2267451B1 (da)
JP (2) JP5081359B2 (da)
AT (2) ATE490464T1 (da)
AU (3) AU2001255240A1 (da)
CA (2) CA2403601C (da)
DE (1) DE60143569D1 (da)
DK (1) DK2267451T3 (da)
WO (3) WO2001077391A1 (da)

Families Citing this family (219)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US7253435B2 (en) 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US8497131B2 (en) * 1999-10-06 2013-07-30 Becton, Dickinson And Company Surface enhanced spectroscopy-active composite nanoparticles comprising Raman-active reporter molecules
US7192778B2 (en) * 1999-10-06 2007-03-20 Natan Michael J Surface enhanced spectroscopy-active composite nanoparticles
US20020090650A1 (en) * 2000-04-06 2002-07-11 Quantum Dot Corporation Two-dimensional spectral imaging system
US6734420B2 (en) * 2000-04-06 2004-05-11 Quantum Dot Corporation Differentiable spectral bar code methods and systems
US6898367B2 (en) * 2000-06-17 2005-05-24 Leica Microsystems Heidelberg Gmbh Method and instrument for microscopy
US6586190B2 (en) * 2000-08-18 2003-07-01 Syngenta Participations Ag Parallel high throughput method and kit
EP2085781B2 (en) 2000-10-06 2020-03-11 Life Technologies Corporation Transfectable micelles containing semiconductor nanocrystals
EP1395601A4 (en) * 2000-10-18 2006-04-12 Vitra Bioscience Inc MULTIPLEXED CELL LUMINAIRE SYSTEM
US6892949B2 (en) * 2000-12-29 2005-05-17 Siemens Logistics And Assembly Systems Inc. Low visual impact labeling method and system
US6861263B2 (en) 2001-01-26 2005-03-01 Surromed, Inc. Surface-enhanced spectroscopy-active sandwich nanoparticles
US6586745B2 (en) * 2001-06-19 2003-07-01 Southwest Research Institute Ultraviolet target designator and methodology
US20030148544A1 (en) * 2001-06-28 2003-08-07 Advanced Research And Technology Institute, Inc. Methods of preparing multicolor quantum dot tagged beads and conjugates thereof
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
US6819845B2 (en) 2001-08-02 2004-11-16 Ultradots, Inc. Optical devices with engineered nonlinear nanocomposite materials
US6710366B1 (en) 2001-08-02 2004-03-23 Ultradots, Inc. Nanocomposite materials with engineered properties
US6794265B2 (en) * 2001-08-02 2004-09-21 Ultradots, Inc. Methods of forming quantum dots of Group IV semiconductor materials
US20030066998A1 (en) * 2001-08-02 2003-04-10 Lee Howard Wing Hoon Quantum dots of Group IV semiconductor materials
US7309568B2 (en) * 2001-09-26 2007-12-18 Hitachi, Ltd. Method in inspecting DNA and apparatus therefor
DE10153829A1 (de) * 2001-11-05 2003-05-28 Bayer Ag Assay basierend auf dotierten Nanoteilchen
US8271202B1 (en) 2002-02-11 2012-09-18 Fernandez Dennis S Modified host bio-data management
US20040026684A1 (en) * 2002-04-02 2004-02-12 Nanosys, Inc. Nanowire heterostructures for encoding information
US6996292B1 (en) * 2002-04-18 2006-02-07 Sandia Corporation Staring 2-D hadamard transform spectral imager
GB2387903A (en) * 2002-04-24 2003-10-29 Smartbead Technologies Ltd Multiparameter analysis using tagged molecules
US6788416B2 (en) * 2002-05-22 2004-09-07 Texas Instruments Incorporated Method and apparatus for dynamic DMD testing
GB0216197D0 (en) * 2002-07-12 2002-08-21 Univ Strathclyde Serrs active particles
JPWO2004025550A1 (ja) * 2002-08-19 2006-01-12 福井　眞彌 暗号情報内有材料、その識別方法およびその識別システム
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7901630B2 (en) * 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7508608B2 (en) * 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US20050227252A1 (en) * 2002-08-20 2005-10-13 Moon John A Diffraction grating-based encoded articles for multiplexed experiments
US7164533B2 (en) * 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7399643B2 (en) * 2002-09-12 2008-07-15 Cyvera Corporation Method and apparatus for aligning microbeads in order to interrogate the same
US7900836B2 (en) * 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7441703B2 (en) * 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US7092160B2 (en) * 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
US20100255603A9 (en) * 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
US7985590B2 (en) * 2002-09-26 2011-07-26 Science Application International Corporation Method and system for detection using nanodot taggants
AU2003266932B2 (en) * 2002-09-27 2009-04-09 Mpm-Holding Aps Spatially encoded polymer matrix
US7035308B1 (en) 2002-10-28 2006-04-25 Science Applications International Corporation Method and system for countering laser technology
FR2846445B1 (fr) * 2002-10-29 2005-04-08 Claude Lambert Procede d'authentification par marquage ou tracage chimique d'un objet ou d'une substance.
DE10252628A1 (de) * 2002-11-11 2004-05-19 Forschungszentrum Jülich GmbH Verfahren zur Codierung von Informationen sowie Vorrichtung und Verfahren zur Auswertung der codierten Information
DE20306138U1 (de) 2003-04-16 2003-09-04 Monajembashi Shamci Präparat, insbesondere für die Handhabung mittels einer optischen Pinzette
US7917298B1 (en) 2003-04-17 2011-03-29 Nanosys, Inc. Nanocrystal taggants
US20040259270A1 (en) * 2003-06-19 2004-12-23 Wolf David E. System, device and method for exciting a sensor and detecting analyte
US8796030B2 (en) 2003-07-12 2014-08-05 Parallel Synthesis Technologies, Inc. Methods for optically encoding an object with upconverting materials and compositions used therein
US7538869B2 (en) * 2004-06-30 2009-05-26 Chemimage Corporation Multipoint method for identifying hazardous agents
US20060057729A1 (en) * 2003-09-12 2006-03-16 Illumina, Inc. Diffraction grating-based encoded element having a substance disposed thereon
AU2003285133A1 (en) * 2003-11-05 2005-06-24 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Biofunctionalized quantum dots for biological imaging
EP1687024B1 (en) * 2003-11-05 2011-10-19 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Carbohydrate antigen-nanoparticle conjugates and uses thereof as antimetastatic agents in treating cancer
US20050136412A1 (en) * 2003-12-22 2005-06-23 Affymetrix, Inc. Light-based detection and manipulation of single molecules
WO2005062018A2 (en) 2003-12-22 2005-07-07 Versamatrix A/S Apparatus and methods for analysis and sorting of particles such as polymer beads
US7433123B2 (en) * 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US7202943B2 (en) * 2004-03-08 2007-04-10 National Research Council Of Canada Object identification using quantum dots fluorescence allocated on Fraunhofer solar spectral lines
US7999455B2 (en) * 2006-11-13 2011-08-16 Research Triangle Institute Luminescent device including nanofibers and light stimulable particles disposed on a surface of or at least partially within the nanofibers
US20060019265A1 (en) * 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
US7796266B2 (en) 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US7815854B2 (en) * 2004-04-30 2010-10-19 Kimberly-Clark Worldwide, Inc. Electroluminescent illumination source for optical detection systems
WO2006020363A2 (en) * 2004-07-21 2006-02-23 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7837675B2 (en) 2004-07-22 2010-11-23 Shaser, Inc. Method and device for skin treatment with replaceable photosensitive window
US7566942B2 (en) * 2004-10-20 2009-07-28 Massachusetts Institute Of Technology Multi-spectral pixel and focal plane array
US8927892B2 (en) * 2004-10-22 2015-01-06 Parallel Synthesis Technologies Rare earth downconverting phosphor compositions for optically encoding objects and methods and apparatus relating to same
US7682782B2 (en) * 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
CA2586197C (en) 2004-11-04 2012-08-14 Mesophotonics Limited Metal nano-void photonic crystal for enhanced raman spectroscopy
DE602005019791D1 (de) * 2004-11-16 2010-04-15 Illumina Inc Verfahren und vorrichtung zum lesen von kodierten mikrokugeln
US7604173B2 (en) * 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
WO2006055735A2 (en) * 2004-11-16 2006-05-26 Illumina, Inc Scanner having spatial light modulator
US20060134324A1 (en) * 2004-11-17 2006-06-22 Illumina, Inc. Filament with easily removed protective coating and methods for stripping the same
SE0402996D0 (sv) * 2004-12-09 2004-12-09 Alexander M Grishin Microwave Readable Ferroelectric Barcode
JP2008524600A (ja) * 2004-12-16 2008-07-10 インヴィトロジェン コーポレーション 多重化アッセイの較正及び定量化用の量子ドットコード化ビーズセット、及びその使用方法
US7586684B2 (en) * 2005-01-21 2009-09-08 New York University Solute characterization by optoelectronkinetic potentiometry in an inclined array of optical traps
AU2006214762B2 (en) * 2005-02-18 2010-07-08 American Dye Source Inc. Method for encoding materials with a luminescent tag and apparatus for reading same
US7277169B2 (en) * 2005-02-18 2007-10-02 The Regents Of The University Of Michigan Whole spectrum fluorescence detection with ultrafast white light excitation
US20060229819A1 (en) * 2005-04-12 2006-10-12 Eastman Kodak Company Method for imaging an array of microspheres
US8351026B2 (en) 2005-04-22 2013-01-08 Affymetrix, Inc. Methods and devices for reading microarrays
US20060243809A1 (en) * 2005-04-27 2006-11-02 Hodgson Rodney T Combination logo and identification code
US7238957B2 (en) * 2005-05-02 2007-07-03 Raytheon Company Methods and apparatus for presenting images
WO2006119561A1 (en) * 2005-05-10 2006-11-16 Commonwealth Scientific And Industrial Research Organisation High-resolution tracking of industrial process materials using trace incorporation of luminescent markers
US9297092B2 (en) 2005-06-05 2016-03-29 Qd Vision, Inc. Compositions, optical component, system including an optical component, devices, and other products
US20060290000A1 (en) * 2005-06-28 2006-12-28 Wojciech Worwag Composite metal layer formed using metal nanocrystalline particles in an electroplating bath
US7227128B2 (en) * 2005-06-30 2007-06-05 Applera Corporation System and methods for improving signal/noise ratio for signal detectors
US7817273B2 (en) * 2005-06-30 2010-10-19 Life Technologies Corporation Two-dimensional spectral imaging system
US7663750B2 (en) 2005-06-30 2010-02-16 Applied Biosystems, Llc Two-dimensional spectral imaging system
WO2007014267A2 (en) * 2005-07-26 2007-02-01 Oregon Health & Science University Nanoparticle probes for capture, sorting and placement of targets
US7871770B2 (en) 2005-08-09 2011-01-18 Maxwell Sensors, Inc. Light transmitted assay beads
US8232092B2 (en) * 2005-08-09 2012-07-31 Maxwell Sensors, Inc. Apparatus and method for digital magnetic beads analysis
US7858307B2 (en) * 2005-08-09 2010-12-28 Maxwell Sensors, Inc. Light transmitted assay beads
US20090201504A1 (en) * 2005-08-09 2009-08-13 Maxwell Sensors, Inc. Hydrodynamic focusing for analyzing rectangular microbeads
WO2007035597A2 (en) * 2005-09-16 2007-03-29 Hypermed, Inc. Disposable calibration-fiducial mark for hyperspectral imaging
US7745788B2 (en) * 2005-09-23 2010-06-29 Massachusetts Institute Of Technology Optical trapping with a semiconductor
US8673107B2 (en) * 2005-10-28 2014-03-18 Parallel Synthesis Technologies Methods for fabricating optically encoded particles and methods for optically encoding objects with such particles
US20090298197A1 (en) * 2005-11-15 2009-12-03 Oxonica Materials Inc. Sers-based methods for detection of bioagents
US7623624B2 (en) * 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
US8409863B2 (en) 2005-12-14 2013-04-02 Becton, Dickinson And Company Nanoparticulate chemical sensors using SERS
JP5537034B2 (ja) 2005-12-23 2014-07-02 ナノストリング テクノロジーズ，インコーポレーテッド ナノレポーターならびにその作製方法および使用方法
US7723100B2 (en) 2006-01-13 2010-05-25 Becton, Dickinson And Company Polymer coated SERS nanotag
US8835185B2 (en) * 2006-01-18 2014-09-16 Canon Kabushiki Kaisha Target substance-detecting element
US7226752B1 (en) 2006-01-19 2007-06-05 Avago Technologies General Ip (Singapore) Pte. Ltd. Methods for detecting an analyte in a sample
ES2601391T3 (es) * 2006-01-27 2017-02-15 Becton Dickinson And Company Inmunoensayo de flujo lateral con modalidad de detección encapsulada
US7995202B2 (en) 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7715001B2 (en) * 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7692783B2 (en) * 2006-02-13 2010-04-06 Pacific Biosciences Of California Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
CA2571904A1 (en) * 2006-02-15 2007-08-15 Fio Corporation System and method of detecting pathogens
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US7583378B2 (en) * 2006-02-23 2009-09-01 Itt Manufacturing Enterprises, Inc. Spectrograph calibration using known light source and Raman scattering
EP2041478B1 (en) 2006-03-07 2014-08-06 QD Vision, Inc. An article including semiconductor nanocrystals
US8849087B2 (en) 2006-03-07 2014-09-30 Qd Vision, Inc. Compositions, optical component, system including an optical component, devices, and other products
WO2007112088A2 (en) 2006-03-24 2007-10-04 Qd Vision, Inc. Hyperspectral imaging device
WO2007117672A2 (en) 2006-04-07 2007-10-18 Qd Vision, Inc. Methods of depositing nanomaterial & methods of making a device
US7830575B2 (en) * 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
EP2044402B2 (en) * 2006-07-24 2016-11-30 Becton Dickinson and Company Apparatus and method for performing an assay using magnetic particles
US7764361B2 (en) * 2006-07-27 2010-07-27 Northwestern University Systems and methods to analyze multiplexed bead-based assays using backscattered light
JP2010503866A (ja) * 2006-09-15 2010-02-04 ヘモネティクス コーポレイション 官能化された表面に関する粒子の光学的操作による表面マッピング
US8709789B2 (en) * 2006-11-20 2014-04-29 Hypromatrix, Inc. Methods and devices for rapid and specific detection of multiple proteins
WO2008063652A1 (en) * 2006-11-21 2008-05-29 Qd Vision, Inc. Blue emitting semiconductor nanocrystals and compositions and devices including same
CA2580589C (en) 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
EP2109900A1 (en) * 2007-01-08 2009-10-21 Plextronics, Inc. Quantum dot photovoltaic device
US8836212B2 (en) 2007-01-11 2014-09-16 Qd Vision, Inc. Light emissive printed article printed with quantum dot ink
WO2008095081A2 (en) * 2007-02-01 2008-08-07 Evident Technologies Markers comprising light-emitting semiconductor nanocrystals and their use
GB0702092D0 (en) * 2007-02-02 2007-03-14 Fracture Code Corp Aps Graphic Code Application Apparatus and Method
US20080191027A1 (en) * 2007-02-12 2008-08-14 San Ming Yang Semiconductor nanocrystals as marking devices
US20090024003A1 (en) * 2007-03-28 2009-01-22 N.V. Organon Accurate method to assess disease severity in clinical trials concerning psychopathology
US8360321B2 (en) 2007-04-02 2013-01-29 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
CA2984820C (en) 2007-04-04 2021-12-07 Ande Corporation Plastic microfluidic separation and detection platforms
US8003314B2 (en) 2007-04-16 2011-08-23 Diagnostic Hybrids, Inc. Methods for direct fluorescent antibody virus detection in liquids
US8597729B2 (en) 2007-06-22 2013-12-03 Fio Corporation Systems and methods for manufacturing quantum dot-doped polymer microbeads
US8551786B2 (en) * 2007-07-09 2013-10-08 Fio Corporation Systems and methods for enhancing fluorescent detection of target molecules in a test sample
US20100257027A1 (en) * 2007-07-23 2010-10-07 Fio Corporation Method and system for collating, storing, analyzing and enabling access to collected and analyzed data associated with biological and environmental test subjects
EP2402725B1 (en) * 2007-07-31 2017-09-27 Nippon Telegraph And Telephone Corporation Spectroscope
US8611619B2 (en) * 2007-08-22 2013-12-17 Phadia Ab Read-out method and apparatus
EP2201374B1 (en) 2007-08-30 2015-10-07 Trustees Of Tufts College Methods for determining the concentration of an analyte in solution.
WO2009082523A2 (en) * 2007-09-26 2009-07-02 Massachusetts Institute Of Technology High-resolution 3d imaging of single semiconductor nanocrystals
WO2009048833A1 (en) * 2007-10-09 2009-04-16 Siemens Healthcare Diagnostics Inc. Two dimensional imaging of reacted areas on a reagent
EP2209549A4 (en) 2007-10-12 2014-03-05 Fio Corp FLOW FOCUSING SYSTEM AND SYSTEM FOR FORMING CONCENTRATED VOLUMES OF MICRO BEADS AND FURTHER MICRO BEADS
JP5186176B2 (ja) * 2007-10-19 2013-04-17 株式会社ジェーシービー 認証システム及び認証用可搬媒体
US9395534B2 (en) * 2007-11-27 2016-07-19 Wisconsin Alumni Research Foundation Optical system for correction of tissue induced aberration
EP2252229B1 (en) * 2008-03-11 2012-12-05 Shaser, Inc. Enhancing optical radiation systems used in dermatologic treatments
JP2011524064A (ja) 2008-05-06 2011-08-25 キユーデイー・ビジヨン・インコーポレーテツド 量子閉じ込め半導体ナノ粒子を含有する固体照明装置
US9207385B2 (en) 2008-05-06 2015-12-08 Qd Vision, Inc. Lighting systems and devices including same
WO2009137053A1 (en) 2008-05-06 2009-11-12 Qd Vision, Inc. Optical components, systems including an optical component, and devices
WO2010002540A2 (en) 2008-06-05 2010-01-07 Life Technologies Corporation Activation and monitoring of cellular transmembrane potentials
JP4931091B2 (ja) * 2008-06-06 2012-05-16 Ｉｄｅｃ株式会社 識別情報含有物、情報識別装置及び情報識別方法
WO2009155704A1 (en) 2008-06-25 2009-12-30 Fio Corporation Bio-threat alert system
EP2303771B1 (en) * 2008-06-30 2018-05-30 Life Technologies Corporation Methods for isolating and purifying nanoparticles from a complex medium
JP5508416B2 (ja) * 2008-07-24 2014-05-28 ザ リージェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア ディスパーシブフーリエ変換イメージングの装置および方法
CA2733609C (en) 2008-08-14 2018-03-06 Nanostring Technologies, Inc. Stable nanoreporters
US8446463B2 (en) * 2008-08-22 2013-05-21 Genprime, Inc. Apparatus, method and article to perform assays using assay strips
US20100050793A1 (en) * 2008-08-28 2010-03-04 Dong June Ahn Flexible chemical sensors
CN105759021A (zh) 2008-08-29 2016-07-13 Fio公司 用于检测生物和环境检测样品的一次性手持式诊断检测设备和相关系统与方法
RU2578023C2 (ru) 2009-01-13 2016-03-20 Эф-Ай-Оу Корпорейшн Портативный диагностический прибор и способ его применения с электронным устройством и диагностическим картриджем при диагностическом экспресс-исследовании
WO2010141105A2 (en) * 2009-01-23 2010-12-09 Bae Systems Information And Electronic Systems Integration Inc. Quantum dot-sensory array for biological recognition
US8886206B2 (en) 2009-05-01 2014-11-11 Digimarc Corporation Methods and systems for content processing
JP2012529908A (ja) 2009-06-15 2012-11-29 ネットバイオ・インコーポレーテッド 法医学的ｄｎａの定量化のための改善された方法
US9749607B2 (en) 2009-07-16 2017-08-29 Digimarc Corporation Coordinated illumination and image signal capture for enhanced signal detection
CN105713599B (zh) 2009-08-14 2018-09-11 三星电子株式会社 发光器件、用于发光器件的光学元件、以及方法
AU2010292939B2 (en) * 2009-09-09 2014-09-18 Absolute Software Corporation Alert for real-time risk of theft or loss
AU2010306862B2 (en) 2009-10-13 2015-08-27 Nanostring Technologies, Inc. Protein detection via nanoreporters
US8524450B2 (en) 2009-10-30 2013-09-03 Illumina, Inc. Microvessels, microparticles, and methods of manufacturing and using the same
US8889416B2 (en) * 2010-01-21 2014-11-18 California Institute Of Technology Methods and devices for micro-isolation, extraction, and/or analysis of microscale components
CA2785529C (en) 2010-02-11 2019-01-08 Nanostring Technologies, Inc. Compositions and methods for the detection of small rnas
JP4965706B2 (ja) * 2010-02-26 2012-07-04 Ｉｄｅｃ株式会社 蛍光スペクトルの識別方法
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
EP2542890B1 (en) 2010-03-01 2015-05-06 Quanterix Corporation Methods for extending dynamic range in assays for the detection of molecules or particles
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
KR20130057451A (ko) * 2010-06-14 2013-05-31 트루테그 테크놀로지스, 인코포레이티드 식별자를 가진 패키징된 아이템을 생성하기 위한 시스템
US8695618B2 (en) 2010-12-22 2014-04-15 Carnegie Mellon University 3D chemical pattern control in 2D fluidics devices
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US9758834B2 (en) 2011-03-28 2017-09-12 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
EP2691752A4 (en) * 2011-03-31 2014-09-17 Gnubio Inc SCALABLE SPECTROSCOPIC DETECTION AND MEASUREMENT
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
WO2012155084A1 (en) 2011-05-12 2012-11-15 Netbio, Inc. Methods and compositions for rapid multiplex amplification of str loci
US8610970B1 (en) * 2011-08-20 2013-12-17 Darwin Hu Liquid crystal display (LCD) scanners
WO2013039883A1 (en) 2011-09-12 2013-03-21 Abbvie Biotherapeutics Inc. Artificial nk cells and uses thereof
WO2013076531A1 (en) * 2011-11-23 2013-05-30 Nokia Corporation An apparatus and method comprising a beam splitter
EP4361606A2 (en) 2012-02-03 2024-05-01 California Institute of Technology Signal encoding and decoding in multiplexed biochemical assays
US9593982B2 (en) 2012-05-21 2017-03-14 Digimarc Corporation Sensor-synchronized spectrally-structured-light imaging
CN104919054A (zh) * 2012-07-31 2015-09-16 胡安·卡洛斯·海梅 获得并检测待鉴定对象之标志物的方法、相关标志物、认证方法以及验证方法
EP3901243A1 (en) 2012-08-03 2021-10-27 California Institute of Technology Multiplexing and quantification in pcr with reduced hardware and requirements
WO2014031902A2 (en) 2012-08-23 2014-02-27 The Regents Of The University Of California Spectrally encoded microbeads and methods and devices for making and using same
CA2889024C (en) 2012-10-23 2018-03-27 Koc Universitesi A method and an apparatus for the detection of a tagging material in fluids
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
EP2950704B1 (en) * 2013-01-29 2017-10-18 Philips Lighting Holding B.V. A light source, luminaire and surgical illumination unit
DE102013006545B4 (de) * 2013-04-16 2020-02-27 Dräger Safety AG & Co. KGaA Messvorrichtung und Messverfahren für einen Reaktionsträger
US9621760B2 (en) 2013-06-07 2017-04-11 Digimarc Corporation Information coding and decoding in spectral differences
JP6206871B2 (ja) * 2013-07-17 2017-10-04 国立研究開発法人理化学研究所 光学顕微鏡システム
WO2015124942A2 (en) * 2014-02-20 2015-08-27 Malvern Instruments Limited Heterogeneous fluid sample characterization
DE112015002758T5 (de) * 2014-06-11 2017-04-20 Micromass Uk Limited Markieren von ADC-Koaleszenz
WO2016010494A1 (en) 2014-07-17 2016-01-21 Kuantag Nanoteknolojiler Geliştirme Ve Üretim A.Ş. A fluorescent substance detection system
US10113910B2 (en) 2014-08-26 2018-10-30 Digimarc Corporation Sensor-synchronized spectrally-structured-light imaging
US9920315B2 (en) 2014-10-10 2018-03-20 California Institute Of Technology Methods and devices for micro-isolation, extraction, and/or analysis of microscale components in an array
US9677935B2 (en) * 2014-11-03 2017-06-13 Trutag Technologies, Inc. Fabry-perot spectral image measurement
US9727941B1 (en) 2014-11-19 2017-08-08 Digimarc Corporation Optimizing optical scanners for digital watermark detection
US9867250B1 (en) 2015-04-20 2018-01-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona System having a configurable pico-second pulsed LED driver circuit and photomultiplier tube biasing and gating circuits for real-time, time-resolved transient recording of fluorescence
US20160371704A1 (en) 2015-06-18 2016-12-22 Kuantag Nanoteknolojiler Gelistirme Ve Uretim A.S. Integrated fuel tracking system
EP3317624B1 (en) 2015-07-05 2019-08-07 The Whollysee Ltd. Optical identification and characterization system and tags
SG10202107055SA (en) 2015-07-17 2021-08-30 Nanostring Technologies Inc Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue
SG10202107053QA (en) 2015-07-17 2021-08-30 Nanostring Technologies Inc Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
EP3313573A2 (en) * 2015-07-22 2018-05-02 The University of North Carolina at Chapel Hill Fluidic devices with bead well geometries with spatially separated bead retention and signal detection segments and related methods
US10203246B2 (en) * 2015-11-20 2019-02-12 Verifood, Ltd. Systems and methods for calibration of a handheld spectrometer
WO2017218777A1 (en) 2016-06-17 2017-12-21 California Institute Of Technology Nucleic acid reactions and related methods and compositions
US10347364B2 (en) 2016-09-14 2019-07-09 International Business Machines Corporation Encoding data from genetic traits relevant to illness diagnosis and heritage
US10576475B2 (en) 2016-09-15 2020-03-03 Genprime, Inc. Diagnostic assay strip cassette
WO2018070324A1 (ja) * 2016-10-13 2018-04-19 国立研究開発法人産業技術総合研究所 ナノ粒子評価方法およびナノ粒子観察装置
AU2017361521B2 (en) 2016-11-21 2020-08-27 Nanostring Technologies, Inc. Chemical compositions and methods of using same
US10324041B2 (en) 2016-12-21 2019-06-18 Abbott Japan Co., Ltd. Optical imaging system using lateral illumination for digital assays
US11047854B2 (en) 2017-02-06 2021-06-29 Abbott Japan Llc Methods for reducing noise in signal-generating digital assays
JP7089719B2 (ja) * 2017-02-07 2022-06-23 ナノフォトン株式会社 分光顕微鏡、及び分光観察方法
FR3075926B1 (fr) * 2017-12-21 2021-04-02 Valeo Vision Dispositif d’eclairage de vehicule automobile
WO2019157445A1 (en) 2018-02-12 2019-08-15 Nanostring Technologies, Inc. Biomolecular probes and methods of detecting gene and protein expression
SG11202011274YA (en) 2018-05-14 2020-12-30 Nanostring Technologies Inc Chemical compositions and methods of using same
JP7022670B2 (ja) * 2018-09-10 2022-02-18 株式会社日立ハイテク スペクトル校正装置及びスペクトル校正方法
JP7447897B2 (ja) * 2019-05-30 2024-03-12 ソニーグループ株式会社 光学測定装置及び光学測定システム
CN111474154B (zh) * 2020-04-27 2023-01-17 广东博创佳禾科技有限公司 一种青枯病菌检测光源激发方法及系统
US20230363707A1 (en) * 2020-09-25 2023-11-16 The Regents Of The University Of California Devices and related methods for physiological examination
CN113514446B (zh) * 2021-05-26 2022-11-22 哈尔滨工业大学 一种用于快速匹配识别sers谱图的方法

Family Cites Families (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6603007A (da) * 1965-03-08 1966-09-09
US3663813A (en) * 1970-01-19 1972-05-16 American Cyanamid Co Optical reader for luminescent codes luminescing in different wavelengths
US3628016A (en) * 1970-11-27 1971-12-14 Pitney Bowes Alpex Photoelectric reader for fluorescent ink imprinted coded document
US4215275A (en) 1977-12-07 1980-07-29 Luxtron Corporation Optical temperature measurement technique utilizing phosphors
US4485308A (en) * 1982-04-26 1984-11-27 General Electric Company Photo detection system
JPS59214725A (ja) 1983-05-20 1984-12-04 Agency Of Ind Science & Technol 蒸気圧温度計
DK641487A (da) * 1987-12-07 1989-06-08 Gluetech Aps Fremgangsmaade til modificering af polymeroverflader
JPH03279860A (ja) * 1990-03-29 1991-12-11 Mitsui Petrochem Ind Ltd 検査方法及び検査試薬
US5723218A (en) 1990-04-16 1998-03-03 Molecular Probes, Inc. Dipyrrometheneboron difluoride labeled flourescent microparticles
US5079169A (en) 1990-05-22 1992-01-07 The Regents Of The Stanford Leland Junior University Method for optically manipulating polymer filaments
US5460831A (en) * 1990-06-22 1995-10-24 The Regents Of The University Of California Targeted transfection nanoparticles
US5495334A (en) * 1990-07-26 1996-02-27 Research Development Corporation Of Japan Fourier transform spectroscope with quadrangular common path interferometer
US5665582A (en) * 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
US5817462A (en) * 1995-02-21 1998-10-06 Applied Spectral Imaging Method for simultaneous detection of multiple fluorophores for in situ hybridization and multicolor chromosome painting and banding
EP0613585A4 (en) * 1991-11-22 1995-06-21 Univ California SEMICONDUCTOR NANOCRYSTALS COVALENTLY LINKED TO SOLID INORGANIC SURFACES USING SELF-ASSEMBLED MONO-LAYERS.
US5377003A (en) * 1992-03-06 1994-12-27 The United States Of America As Represented By The Department Of Health And Human Services Spectroscopic imaging device employing imaging quality spectral filters
JPH0622798A (ja) * 1992-07-07 1994-02-01 Hitachi Ltd 塩基配列決定法
GB9220564D0 (en) * 1992-09-29 1992-11-11 Univ London The method of rheological investigation
IL108497A0 (en) * 1993-02-01 1994-05-30 Seq Ltd Methods and apparatus for dna sequencing
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
JP3371113B2 (ja) * 1993-09-08 2003-01-27 三信工業株式会社 縦型多気筒エンジンの燃料供給装置
US5462880A (en) 1993-09-13 1995-10-31 Optical Sensors Incorporated Ratiometric fluorescence method to measure oxygen
JP2576027B2 (ja) 1993-10-20 1997-01-29 カシオ計算機株式会社 文書書式の設定方法及び装置
US5958782A (en) 1993-10-21 1999-09-28 Minnesota Mining And Manufacturing Company Cation-sensing composite structure and compounds for use therein
US5695928A (en) 1993-12-10 1997-12-09 Novartis Corporation Rapid immunoassay for detection of antibodies or antigens incorporating simultaneous sample extraction and immunogenic reaction
JPH07227299A (ja) * 1994-02-14 1995-08-29 Kyoto Daiichi Kagaku:Kk Ｄｎａの特定塩基配列の検出方法及びその装置
US5512745A (en) 1994-03-09 1996-04-30 Board Of Trustees Of The Leland Stanford Jr. University Optical trap system and method
EP0700980B1 (en) * 1994-03-17 1999-11-17 Hitachi Maxell, Ltd. PHOSPHOR, PHOSPHOR COMPOSITION and FLUORESCENT MARK CARRIER
US5537000A (en) * 1994-04-29 1996-07-16 The Regents, University Of California Electroluminescent devices formed using semiconductor nanocrystals as an electron transport media and method of making such electroluminescent devices
US5483338A (en) 1994-05-26 1996-01-09 Martin Marietta Energy Systems, Inc. Method and apparatus for evaluating structural weakness in polymer matrix composites
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5525798A (en) * 1994-12-01 1996-06-11 Pitney Bowes Inc. Bar code scanner for reading a lower layer luminescent invisible ink that is printed below a upper layer luminescent invisible ink
ATE254965T1 (de) * 1995-04-25 2003-12-15 Discovery Partners Internation Fernprogrammierbare matrizen mit speichern und verwendungen davon
US6352854B1 (en) 1995-04-25 2002-03-05 Discovery Partners International, Inc. Remotely programmable matrices with memories
US5631141A (en) * 1995-05-05 1997-05-20 The Regents Of The University Of California High resolution biosensor for in-situ microthermometry
US6017434A (en) * 1995-05-09 2000-01-25 Curagen Corporation Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments
US5776674A (en) * 1995-06-05 1998-07-07 Seq, Ltd Chemical biochemical and biological processing in thin films
US5620857A (en) 1995-06-07 1997-04-15 United States Of America, As Represented By The Secretary Of Commerce Optical trap for detection and quantitation of subzeptomolar quantities of analytes
US6057103A (en) * 1995-07-18 2000-05-02 Diversa Corporation Screening for novel bioactivities
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US5756007A (en) * 1995-11-16 1998-05-26 Lucent Technologies Inc. Composition for protection of devices
WO1997035176A1 (en) * 1996-03-19 1997-09-25 University Of Utah Research Foundation Lens and associatable flow cell
US5945526A (en) * 1996-05-03 1999-08-31 Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
EP0920608B1 (en) * 1996-08-22 2005-01-26 Eastman Chemical Company On-line quantitative analysis of chemical compositions by raman spectrometry
US5786219A (en) * 1996-10-28 1998-07-28 Molecular Probes, Inc. Microspheres with fluorescent spherical zones
US6024925A (en) 1997-01-23 2000-02-15 Sequenom, Inc. Systems and methods for preparing low volume analyte array elements
US6054325A (en) 1996-12-02 2000-04-25 Glaxo Wellcom Inc. Method and apparatus for transferring and combining distinct chemical compositions with reagents
US5990476A (en) 1996-12-17 1999-11-23 Physical Electronics Inc Control of surface potential of insulating specimens in surface analysis
US5939021A (en) 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
JP4209471B2 (ja) 1997-02-20 2009-01-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア プラズモン共鳴粒子、方法、および装置
JPH1151935A (ja) * 1997-08-06 1999-02-26 Aisin Seiki Co Ltd 複数種類のターゲット分子の同時検出方法
US6297018B1 (en) * 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US7348181B2 (en) * 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US6322901B1 (en) 1997-11-13 2001-11-27 Massachusetts Institute Of Technology Highly luminescent color-selective nano-crystalline materials
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6055106A (en) 1998-02-03 2000-04-25 Arch Development Corporation Apparatus for applying optical gradient forces
JP3944996B2 (ja) * 1998-03-05 2007-07-18 株式会社日立製作所 Ｄｎａプローブアレー
US6388788B1 (en) 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
US6501091B1 (en) * 1998-04-01 2002-12-31 Massachusetts Institute Of Technology Quantum dot white and colored light emitting diodes
WO1999052708A1 (en) * 1998-04-13 1999-10-21 Luminex Corporation Liquid labeling with fluorescent microparticles
US6384409B1 (en) * 1998-04-22 2002-05-07 Mqs, Inc. Optical tracking system
US6139831A (en) * 1998-05-28 2000-10-31 The Rockfeller University Apparatus and method for immobilizing molecules onto a substrate
ATE423314T1 (de) * 1998-06-24 2009-03-15 Illumina Inc Dekodierung von matrixartig-angeordneten sensoren durch mikropartikel
EP1088229A4 (en) * 1998-06-25 2002-05-08 Caliper Techn Corp HIGH THROUGHPUT METHODS, SYSTEMS AND APPARATUS FOR CELL SCREENING TEST
US6159749A (en) * 1998-07-21 2000-12-12 Beckman Coulter, Inc. Highly sensitive bead-based multi-analyte assay system using optical tweezers
JP2002521685A (ja) * 1998-07-27 2002-07-16 セダーシナイ メディカル センター 哺乳類の物質のスペクトル・トポグラフィ
JP2002524845A (ja) 1998-09-02 2002-08-06 エムイーエムシー・エレクトロニック・マテリアルズ・インコーポレイテッド 欠陥密度が低い単結晶シリコンから得られるシリコン・オン・インシュレーター構造体
IL141759A0 (en) * 1998-09-03 2002-03-10 Trellis Bioinformatics Inc Multihued labels
US6642062B2 (en) * 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
US6821402B1 (en) * 1998-09-16 2004-11-23 Applera Corporation Spectral calibration of fluorescent polynucleotide separation apparatus
US6326144B1 (en) * 1998-09-18 2001-12-04 Massachusetts Institute Of Technology Biological applications of quantum dots
US6251303B1 (en) * 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
EP1116036B1 (en) * 1998-09-18 2004-08-11 Massachusetts Institute Of Technology Water-soluble fluorescent semiconductor nanocrystals
EP0990903B1 (en) 1998-09-18 2003-03-12 Massachusetts Institute Of Technology Biological applications of semiconductor nanocrystals
US6617583B1 (en) 1998-09-18 2003-09-09 Massachusetts Institute Of Technology Inventory control
US6306610B1 (en) 1998-09-18 2001-10-23 Massachusetts Institute Of Technology Biological applications of quantum dots
ATE389030T1 (de) 1998-09-24 2008-03-15 Univ Indiana Res & Tech Corp Wasserlösliche lumineszente quantum-dots sowie deren biokonjugate
SE9903407L (sv) 1998-09-26 2000-03-27 Kijang Medical Co Metod för framställning av farmaceutiska artemisia-extrakt samt apparat för elektrisk moxabränning med användande av extraktet
US6309701B1 (en) * 1998-11-10 2001-10-30 Bio-Pixels Ltd. Fluorescent nanocrystal-labeled microspheres for fluorescence analyses
US6333110B1 (en) * 1998-11-10 2001-12-25 Bio-Pixels Ltd. Functionalized nanocrystals as visual tissue-specific imaging agents, and methods for fluorescence imaging
AU1717600A (en) * 1998-11-10 2000-05-29 Biocrystal Limited Methods for identification and verification
US6274873B1 (en) * 1998-11-18 2001-08-14 Dna Technologies Inc. Spectrum analyzer for reading authentication marks
US6255116B1 (en) * 1998-12-17 2001-07-03 Smithkline Beecham Corporation Apparatus and process for arraying beads
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US6263104B1 (en) * 1998-12-31 2001-07-17 Mcgrew Stephen P. Method and apparatus for reading and verifying holograms
ATE556149T1 (de) * 1999-02-23 2012-05-15 Caliper Life Sciences Inc Manipulation von mikropartikeln in mikrofluidischen systemen
US6294343B1 (en) * 1999-11-09 2001-09-25 Eos Biotechnology, Inc. Methods of diagnosing colorectal cancer, compositions, and methods of screening for colorectal cancer modulators
US6235540B1 (en) 1999-03-30 2001-05-22 Coulter International Corp. Semiconductor nanoparticles for analysis of blood cell populations and methods of making same
EP1175505A4 (en) * 1999-04-15 2005-04-20 Vitra Bioscience Inc COMBINATORY CHEMICAL BANK HOLDERS HAVING BRANDS AT CODING POSITIONS, AND METHODS OF USE
US6284465B1 (en) * 1999-04-15 2001-09-04 Agilent Technologies, Inc. Apparatus, systems and method for locating nucleic acids bound to surfaces
WO2000065094A2 (en) * 1999-04-22 2000-11-02 The Albert Einstein College Of Medicine Of Yeshiva University Assay of gene expression patterns by multi-fluor fish
US20010055764A1 (en) * 1999-05-07 2001-12-27 Empedocles Stephen A. Microarray methods utilizing semiconductor nanocrystals
ATE439452T1 (de) 1999-05-07 2009-08-15 Life Technologies Corp Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
AU6779200A (en) 1999-08-17 2001-03-13 Luminex Corporation Encapsulation of fluorescent particles
US6358684B1 (en) * 1999-08-27 2002-03-19 Pe Corporation UV excitable fluorescent energy transfer dyes
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US6252664B1 (en) * 1999-10-15 2001-06-26 Biocrystal Ltd. Fluorescence filter cube for fluorescence detection and imaging
US20050069956A1 (en) * 1999-11-22 2005-03-31 Michael Seul Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
US6225198B1 (en) 2000-02-04 2001-05-01 The Regents Of The University Of California Process for forming shaped group II-VI semiconductor nanocrystals, and product formed using process
US7361488B2 (en) 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US20020004246A1 (en) * 2000-02-07 2002-01-10 Daniels Robert H. Immunochromatographic methods for detecting an analyte in a sample which employ semiconductor nanocrystals as detectable labels
US6770441B2 (en) * 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
WO2001061040A1 (en) * 2000-02-16 2001-08-23 Quantum Dot Corporation Microarray methods utilizing semiconductor nanocrystals
AU2001238447A1 (en) * 2000-02-16 2001-08-27 Quantum Dot Corporation Single target counting assays using semiconductor nanocrystals
US20020028457A1 (en) * 2000-02-16 2002-03-07 Quantum Dot Corporation Single target counting assays using semiconductor nanocrystals
US20030099940A1 (en) 2000-02-16 2003-05-29 Empedocles Stephen A. Single target counting assays using semiconductor nanocrystals
WO2001063284A2 (en) 2000-02-25 2001-08-30 Luminex Corporation Internal standards and controls for multiplexed assay
CA2403708A1 (en) 2000-03-22 2001-09-27 Quantum Dot Corporation Methods of using semiconductor nanocrystals in bead-based nucleic acid assays
US20020090650A1 (en) * 2000-04-06 2002-07-11 Quantum Dot Corporation Two-dimensional spectral imaging system
US6734420B2 (en) 2000-04-06 2004-05-11 Quantum Dot Corporation Differentiable spectral bar code methods and systems
US7892854B2 (en) 2000-06-21 2011-02-22 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US6649138B2 (en) 2000-10-13 2003-11-18 Quantum Dot Corporation Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
US20030148544A1 (en) 2001-06-28 2003-08-07 Advanced Research And Technology Institute, Inc. Methods of preparing multicolor quantum dot tagged beads and conjugates thereof
WO2003092043A2 (en) 2001-07-20 2003-11-06 Quantum Dot Corporation Luminescent nanoparticles and methods for their preparation
US7041453B2 (en) 2002-08-22 2006-05-09 Bioarray Solutions Ltd. Molecular constructs and methods of use for detection of biochemical reactions
CA2500761C (en) 2002-10-15 2012-11-20 Bernhard O. Palsson Methods and systems to identify operational reaction pathways
JP2008524600A (ja) 2004-12-16 2008-07-10 インヴィトロジェン コーポレーション 多重化アッセイの較正及び定量化用の量子ドットコード化ビーズセット、及びその使用方法
US8360321B2 (en) 2007-04-02 2013-01-29 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates

Also Published As

Publication number Publication date
AU2001249920A1 (en) 2001-10-23
EP2267451A2 (en) 2010-12-29
EP1282734B1 (en) 2011-11-30
US20100210472A1 (en) 2010-08-19
ATE535808T1 (de) 2011-12-15
US6734420B2 (en) 2004-05-11
WO2001078288A2 (en) 2001-10-18
US20020008148A1 (en) 2002-01-24
US20040197816A1 (en) 2004-10-07
EP1274998A4 (en) 2006-02-08
US9304084B2 (en) 2016-04-05
JP5081359B2 (ja) 2012-11-28
US20020031783A1 (en) 2002-03-14
US20150355079A1 (en) 2015-12-10
WO2001078288A3 (en) 2002-03-28
AU2001255240A1 (en) 2001-10-23
CA2403601A1 (en) 2001-10-18
US7079241B2 (en) 2006-07-18
US7559481B2 (en) 2009-07-14
US20150247801A1 (en) 2015-09-03
JP2004500669A (ja) 2004-01-08
EP2267451B1 (en) 2016-04-06
EP1282734A2 (en) 2003-02-12
US8405828B2 (en) 2013-03-26
US9228948B2 (en) 2016-01-05
AU2001253244A1 (en) 2001-10-23
EP1274998A1 (en) 2003-01-15
DE60143569D1 (de) 2011-01-13
US20040178338A1 (en) 2004-09-16
WO2001077391A1 (en) 2001-10-18
EP1282734A4 (en) 2006-02-08
US20160161398A1 (en) 2016-06-09
US20060244963A1 (en) 2006-11-02
WO2001077678A1 (en) 2001-10-18
CA2405267A1 (en) 2001-10-18
US9297762B2 (en) 2016-03-29
US6759235B2 (en) 2004-07-06
ATE490464T1 (de) 2010-12-15
US9046477B2 (en) 2015-06-02
EP1274998B1 (en) 2010-12-01
JP2003531734A (ja) 2003-10-28
US20130172199A1 (en) 2013-07-04
EP2293066A1 (en) 2011-03-09
US20020022273A1 (en) 2002-02-21
CA2403601C (en) 2014-03-25
EP2267451A3 (en) 2011-04-13
US20150168393A1 (en) 2015-06-18

Similar Documents

Publication Publication Date Title
DK2267451T3 (da) Todimensionalt spektralt billedsystem og fremgangsmåde
US6489606B1 (en) Bragg grating sensor system with spectral response or code division multiplexing
ATE330288T1 (de) Verfahren und vorrichtung zum identifizieren und zur positionsbestimmung von objekten
EP1643236A3 (en) Optical image measuring apparatus
CA2216678A1 (en) System for the optical identification of coding on a diagnostic test strip
DE59912658D1 (de) Messanordnung und messmethode zum parallelen auslesen von spr-sensoren
US20040136652A1 (en) Optical waveguide bragg grating system
JPH0781814B2 (ja) 物理的な大きさを遠隔検出するためのオプトエレクトロニクス式方法と装置
ATE486275T1 (de) Verfahren und vorrichtung zur bestimmung mehrerer analyten
CA2327853A1 (en) Apparatus and method for the optical detection of multiple items on a platform
ES2190593T3 (es) Dispositivo para reconocer marcas opticas de difraccion.
WO2001098740A3 (en) Spectrum measuring instrument
ATE285480T1 (de) Verwendung eines bildgebenden photoelektrischen flächensensors zur auswertung von biochips und bildgebungsverfahren hierfür
TW200420728A (en) Optical DNA sensor, DNA reading apparatus, identification method of DNA and manufacturing method of optical DNA sensor
CA2993815C (en) Multi excitation-multi emission fluorometer for multiparameter water quality monitoring
DE50013812D1 (de) Vorrichtung und Verfahren zur Erkennung von tumorösem Gewebe
ATE218202T1 (de) Dreidimensionale farbbildaufnahme
ATE527522T1 (de) Fotodiodensensorarray mit mehrfachauflösung für eine optische kodiervorrichtung
EP0843154A3 (en) Method for measuring shape of object and apparatus for carrying out the same
US20200080941A1 (en) Multi excitation-multi emission fluorometer for multiparameter water quality monitoring
EP0668568A3 (en) Film bar code reader
US7076100B2 (en) Method and apprartus thereof for detecting a hidden image in a hologram
FR2782384B1 (fr) Dispositif de mesure de la taille de particules en deplacement, notamment pour des mesures pluviometriques
Christiansen et al. Digital spatial wavelength domain multiplexing (DSWDM) using a prism-grating-prism (PGP) and a CMOS imager: implementation and initial testing
JPS57189029A (en) Noise suppressing method