DK2260101T3 - MIKRO-RNA (miRNA) miR-21 TIL DIAGNOSTISKE OG TERAPEUTISKE FORMÅL - Google Patents

MIKRO-RNA (miRNA) miR-21 TIL DIAGNOSTISKE OG TERAPEUTISKE FORMÅL

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Publication number
DK2260101T3
DK2260101T3 DK09714079.2T DK09714079T DK2260101T3 DK 2260101 T3 DK2260101 T3 DK 2260101T3 DK 09714079 T DK09714079 T DK 09714079T DK 2260101 T3 DK2260101 T3 DK 2260101T3
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Prior art keywords
mir
mirna
rna
diagnostic
micro
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DK09714079.2T
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Danish (da)
English (en)
Inventor
Thomas Thum
Johann Bauersachs
Stefan Engelhardt
Carina Gross
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Univ Wuerzburg J Maximilians
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    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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DK09714079.2T 2008-02-27 2009-02-26 MIKRO-RNA (miRNA) miR-21 TIL DIAGNOSTISKE OG TERAPEUTISKE FORMÅL DK2260101T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3183508P 2008-02-27 2008-02-27
EP20080003570 EP2096171A1 (en) 2008-02-27 2008-02-27 MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes
US3334008P 2008-03-03 2008-03-03
PCT/EP2009/051986 WO2009106477A1 (en) 2008-02-27 2009-02-19 Microrna (mirna) and down-stream targets for diagnostic and therapeutic purposes
PCT/EP2009/001590 WO2009106367A1 (en) 2008-02-27 2009-02-26 Microrna (mirna) and downstream targets for diagnostic and therapeutic purposes

Publications (1)

Publication Number Publication Date
DK2260101T3 true DK2260101T3 (da) 2013-08-19

Family

ID=39639202

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09714079.2T DK2260101T3 (da) 2008-02-27 2009-02-26 MIKRO-RNA (miRNA) miR-21 TIL DIAGNOSTISKE OG TERAPEUTISKE FORMÅL

Country Status (23)

Country Link
US (10) US8236777B2 (enExample)
EP (3) EP2096171A1 (enExample)
JP (2) JP6033527B2 (enExample)
KR (1) KR101697482B1 (enExample)
CN (1) CN102027113B (enExample)
AU (1) AU2009218704C1 (enExample)
BR (1) BRPI0907565B1 (enExample)
CA (2) CA2716643C (enExample)
CY (1) CY1114426T1 (enExample)
DK (1) DK2260101T3 (enExample)
EA (1) EA020335B1 (enExample)
ES (1) ES2436885T3 (enExample)
HR (1) HRP20130766T1 (enExample)
IL (1) IL207704A (enExample)
ME (1) ME01600B (enExample)
MX (2) MX2010009346A (enExample)
MY (1) MY159454A (enExample)
NZ (1) NZ588185A (enExample)
PL (1) PL2260101T3 (enExample)
PT (1) PT2260101E (enExample)
SI (1) SI2260101T1 (enExample)
UA (1) UA100727C2 (enExample)
WO (2) WO2009106477A1 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2534302T3 (es) 2004-11-12 2015-04-21 Asuragen, Inc. Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
EP2096171A1 (en) 2008-02-27 2009-09-02 Julius-Maximilians-Universität Würzburg MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes
US20110190372A1 (en) * 2009-08-07 2011-08-04 New York University Compositions and methods for treating inflammatory disorders
CN102038959B (zh) * 2009-10-26 2012-12-19 中国科学院上海生命科学研究院 let-7/miR-98家族在制备治疗FAS基因相关疾病的药物中的应用
WO2011126842A2 (en) * 2010-03-30 2011-10-13 Regulus Therapeutics Inc. Targeting micrornas for the treatment of cardiac disorders
US20130150256A1 (en) 2010-06-11 2013-06-13 Jane Synnergren Novel micrornas for the detection and isolation of human embryonic stem cell-derived cardiac cell types
WO2012012716A2 (en) * 2010-07-23 2012-01-26 Regulus Therapeutics, Inc. Targeting micrornas for the treatment of fibrosis
WO2012083005A2 (en) * 2010-12-15 2012-06-21 Miragen Therapeutics Microrna inhibitors comprising locked nucleotides
CN103620035B (zh) * 2011-04-25 2021-04-23 赛诺菲 用于调节mir-21活性的微rna化合物以及方法
CN104011208B (zh) * 2011-09-06 2020-04-10 马普科技促进协会 作为治疗靶的miRNA-212/132家族
KR20140091688A (ko) 2011-10-06 2014-07-22 미라젠 세러퓨틱스 인코포레이티드 마이크로rna 조절에 의한 전신 에너지 항상성의 제어
EP2592145A1 (en) * 2011-11-11 2013-05-15 Medizinische Hochschule Hannover Medicament for the treatment of cardiac disease
MX2014006130A (es) * 2011-11-22 2015-04-13 Intermune Inc Metodos de diagnostico y tratamiento de la fibrosis pulmonar idiopatica.
CA2859430A1 (en) * 2011-12-13 2013-06-20 Ohio State Innovation Foundation Methods and compositions related to mir-21 and mir-29a, exosome inhibition, and cancer metastasis
WO2013153082A1 (en) * 2012-04-10 2013-10-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of nonalcoholic steatohepatitis
BR112014026639A8 (pt) * 2012-04-25 2018-01-16 Regulus Therapeutics Inc compostos , métodos de inibição da atividade de mir-21 , método para diminuir a expressão de colágeno , método para tratar , prevenir ou atrasar o início de uma doença , método de tratamento de um distúrbio fibroproliferativo e usos de um composto.
CA2876180C (en) 2012-06-21 2019-11-19 MiRagen Therapeutics, Inc. Oligonucleotide-based inhibitors comprising locked nucleic acid motif
CA2782942C (en) * 2012-07-12 2019-08-27 Canadian Blood Services Method for inducing immune tolerance using polymer-modified antigenic leukocytes
UA116639C2 (uk) 2012-10-09 2018-04-25 Рег'Юлес Терап'Ютікс Інк. Способи лікування синдрому альпорта
WO2015003240A1 (en) 2013-07-12 2015-01-15 Canadian Blood Services Acellular pro-inflammatory compositions, process for making same and methods of using same
EP3060664B1 (en) 2013-10-25 2021-07-07 Sanofi Microrna compounds and methods for modulating mir-21 activity
EP3079727A1 (en) * 2013-12-12 2016-10-19 INSERM - Institut National de la Santé et de la Recherche Médicale Methods for the prevention and treatment of diabetic cardiomyopathy using mir-424/322
WO2016004538A1 (en) 2014-07-10 2016-01-14 Canadian Blood Services Combination therapy of a cellular pro-tolerogenic and pro-inflammatory preparations for modulating the immune system
EP3201213B1 (en) * 2014-09-08 2021-06-02 Viridian Therapeutics, Inc. Mir-29 mimics and uses thereof
SG11201705907XA (en) 2015-01-20 2017-08-30 Miragen Therapeutics Inc Mir-92 inhibitors and uses thereof
CN106924757B (zh) * 2015-12-31 2020-07-24 中国科学院遗传与发育生物学研究所 miR-449c-5p及其拟似物在制备治疗和预防心脏瓣膜疾病产品中的应用
CN107034216A (zh) * 2016-02-04 2017-08-11 中国科学技术大学 miRancer分子的设计与应用
KR101835018B1 (ko) 2016-03-03 2018-03-06 고려대학교 산학협력단 엑소좀 또는 엑소좀 유래 리보핵산을 포함하는 간섬유증 예방 또는 치료용 조성물
US11236337B2 (en) 2016-11-01 2022-02-01 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
US11667916B2 (en) 2017-09-08 2023-06-06 Korea University Research And Business Foundation Composition for preventing or treating liver fibrosis, containing exosome or exosome-derived ribonucleic acid
CN107858419A (zh) * 2017-11-10 2018-03-30 青岛大学 miRNA的应用、应用其的产品及检测方法
US20210189398A1 (en) 2018-05-25 2021-06-24 Bioneer Corporation Amphiregulin gene-specific double-stranded oligonucleotide and composition for preventing and treating fibrosis-related diseases and respiratory diseases, comprising same
CN109498642A (zh) * 2018-12-21 2019-03-22 复旦大学附属中山医院 一种柯萨奇b3病毒感染导致的心脏微血管病变的靶向治疗药物
KR20230008741A (ko) 2020-04-09 2023-01-16 테크니쉐 우니베르지테트 뮌헨 폐 섬유증 치료를 위한 miR-21 억제제의 대식세포로의 표적 전달
WO2021262919A2 (en) 2020-06-26 2021-12-30 The Research Foundation For The State University Of New York 5-halouracil-modified micrornas and their use in the treatment of cancer
US20230302139A1 (en) * 2020-07-31 2023-09-28 University Of Florida Research Foundation, Incorporated Targeted rna degradation allows precision repurposing of protein-targeted small molecule medicines to rna
WO2022184888A2 (en) * 2021-03-05 2022-09-09 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for use in the treatment of corneal dystrophies
KR102549208B1 (ko) * 2021-04-08 2023-06-30 연세대학교 산학협력단 심혈관 질환과 관련된 LncRNA 및 이의 용도
CN118667869B (zh) * 2024-07-10 2025-06-27 中国水稻研究所 水稻氮素利用基因nu4在调控水稻生长中的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1768139A (zh) * 2003-02-10 2006-05-03 独立行政法人产业技术总合研究所 通过dna干扰调控基因的表达
EP1606406B2 (en) * 2003-03-21 2013-11-27 Santaris Pharma A/S SHORT INTERFERING RNA (siRNA) ANALOGUES
CN1905876B (zh) * 2003-11-17 2010-06-09 诺瓦提斯公司 二肽基肽酶iv抑制剂的用途
CA2566519C (en) 2004-05-14 2020-04-21 Rosetta Genomics Ltd. Micrornas and uses thereof
US20060142193A1 (en) * 2004-11-09 2006-06-29 Baylor College Of Medicine Selective inhibition of rock1 in cardiac therapy
US20070213292A1 (en) * 2005-08-10 2007-09-13 The Rockefeller University Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
CA3024953A1 (en) * 2006-04-03 2007-10-11 Roche Innovation Center Copenhagen A/S Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
EP2476762B1 (de) 2006-10-09 2014-01-08 Julius-Maximilians-Universität Würzburg MicroRNA (miRNA) zur Diagnose und Therapie von Herzerkrankungen
AU2007333107A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. miR-21 regulated genes and pathways as targets for therapeutic intervention
WO2009058818A2 (en) 2007-10-29 2009-05-07 The Board Of Regents Of The University Of Texas System Compositions comprising a micro-rna and methods of their use in regulating cardiac remodeling
EP2096171A1 (en) 2008-02-27 2009-09-02 Julius-Maximilians-Universität Würzburg MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes

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