DK2214701T3 - CONFIGURATIONS AND METHODS FOR IMPROVING THE IMMUNE RESPONSES TO Eimeria - Google Patents
CONFIGURATIONS AND METHODS FOR IMPROVING THE IMMUNE RESPONSES TO Eimeria Download PDFInfo
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- DK2214701T3 DK2214701T3 DK08843740.5T DK08843740T DK2214701T3 DK 2214701 T3 DK2214701 T3 DK 2214701T3 DK 08843740 T DK08843740 T DK 08843740T DK 2214701 T3 DK2214701 T3 DK 2214701T3
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| JP3308534B2 (ja) | 1991-10-25 | 2002-07-29 | イミュネックス・コーポレーション | 新規なサイトカイン |
| US5716805A (en) * | 1991-10-25 | 1998-02-10 | Immunex Corporation | Methods of preparing soluble, oligomeric proteins |
| US5981724A (en) * | 1991-10-25 | 1999-11-09 | Immunex Corporation | DNA encoding CD40 ligand, a cytokine that binds CD40 |
| EP0659086B1 (en) * | 1992-09-04 | 1998-11-11 | The University of Saskatchewan | Novel bacterial vaccines using vaccine strains of pathogenic bacteria |
| US5540926A (en) * | 1992-09-04 | 1996-07-30 | Bristol-Myers Squibb Company | Soluble and its use in B cell stimulation |
| JP4242447B2 (ja) * | 1993-01-22 | 2009-03-25 | イミュネックス・コーポレーション | Ｃｄ４０リガンド遺伝子の突然変異の検出および治療 |
| AU1059095A (en) | 1993-11-24 | 1995-06-13 | Australian National University, The | Treatment of viral disease with cd40l peptide |
| ATE309267T1 (de) * | 1994-04-28 | 2005-11-15 | Boehringer Ingelheim Pharma | Methode zur proliferation und differenzierung von b-zellen und verwendungen dafür |
| CA2213798C (en) | 1995-03-01 | 2001-02-06 | Immunex Corporation | Method for stimulating an immune response |
| KR100453314B1 (ko) | 1995-06-07 | 2004-12-17 | 임뮤넥스 코포레이션 | Cd40l 돌연변이 단백질 |
| US6713279B1 (en) * | 1995-12-07 | 2004-03-30 | Diversa Corporation | Non-stochastic generation of genetic vaccines and enzymes |
| US6479258B1 (en) * | 1995-12-07 | 2002-11-12 | Diversa Corporation | Non-stochastic generation of genetic vaccines |
| US6306387B1 (en) * | 1997-05-29 | 2001-10-23 | The Research Foundation Of State University Of New York | Antigen delivery system |
| US20030045492A1 (en) | 1997-08-13 | 2003-03-06 | Tang De-Chu C. | Vaccination by topical application of recombinant vectors |
| US6969609B1 (en) * | 1998-12-09 | 2005-11-29 | The United States Of America As Represented By The Department Of Health And Human Serivces | Recombinant vector expressing multiple costimulatory molecules and uses thereof |
| CA2223225A1 (en) | 1997-11-28 | 1999-05-28 | Canadian Red Cross Society | Method for inhibiting in vivo immune response |
| CA2313805A1 (en) | 1997-12-19 | 1999-07-01 | Immunex Corporation | Method for reducing susceptibility to hiv infection |
| GB9806449D0 (en) * | 1998-03-25 | 1998-05-27 | Peptide Therapeutics Ltd | Attenuated bacteria useful in vaccines |
| US6190669B1 (en) * | 1998-05-13 | 2001-02-20 | University Of Maryland, Baltimore | Attenuated mutants of salmonella which constitutively express the Vi antigen |
| DE69939264D1 (de) * | 1998-09-04 | 2008-09-18 | Emergent Product Dev Uk Ltd | Attenuierte salmonella spi2 mutante als antigen-träger |
| US7300774B1 (en) * | 1999-12-09 | 2007-11-27 | The Regents Of The University Of California | Multimeric fusion proteins of the TNF superfamily ligands |
| EP1067194A1 (en) | 1999-04-16 | 2001-01-10 | F. Hoffmann-La Roche Ag | Vectors containing a gene coding for CD40 and/or CD40L under the control of a cytokine-inducible promoter which is a human acute phase amyloid A gene promoter. Methods for their production and uses thereof |
| IL144952A0 (en) | 1999-04-16 | 2002-06-30 | Hoffmann La Roche | Nucleic acids encoding cd40/cd40l chimeric polypeptides, methods for their production and uses thereof |
| US7803765B2 (en) * | 1999-05-05 | 2010-09-28 | Phylogica Limited | Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom |
| WO2001026608A2 (en) * | 1999-10-14 | 2001-04-19 | Ledbetter Jeffrey A | Dna vaccines encoding antigen linked to a domain that binds cd40 |
| DE60011560T2 (de) * | 1999-12-28 | 2005-08-18 | Akzo Nobel N.V. | Salmonella Impfstoff, der keinen Antikörper gegen Flagellin oder gegen Flagella induziert |
| US7371392B2 (en) * | 2000-02-02 | 2008-05-13 | The United States Of America As Represented By The Department Of Health And Human Services | Cd40 ligand adjuvant for respiratory syncytial virus |
| AU2001256957B2 (en) * | 2000-03-17 | 2005-08-25 | Pharmacia & Upjohn Company Llc | Salmonella vaccine materials and methods |
| GB0015426D0 (en) * | 2000-06-24 | 2000-08-16 | Univ Southampton | Method for generating soluble highly multimeric proteins |
| US20030165538A1 (en) | 2000-06-26 | 2003-09-04 | Maxygen Incorporated | Methods and compositions for developing spore display systems for medicinal and industrial applications |
| WO2002036769A2 (en) | 2000-10-31 | 2002-05-10 | F. Hoffmann-La Roche Ag | Nucleic acids encoding cd40/cd40l chimeric polypeptides, methods for their production and uses thereof |
| US6855493B2 (en) * | 2000-11-28 | 2005-02-15 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
| PT1407004E (pt) * | 2001-05-15 | 2009-08-31 | Ortho Mcneil Janssen Pharm | Iniciação ex-vivo para produção de linfócitos t citotóxicos específicos de ligando-cd40 para tratar doenças autoimunes e alérgicas |
| ZA200400479B (en) * | 2001-07-06 | 2006-05-31 | Abic Biolog Lab Teva | Nucleic acids encoding recombinant 56 a 82 KDA antigens from gametocytes of Eimeria maxima and their use |
| RU2004103468A (ru) * | 2001-07-06 | 2005-04-20 | Абик Байолоджикал Лэборетериз Тева Лтд. (Il) | Нуклеиновые кислоты, кодирующие рекомбинантный 250 к-да-антиген спорозоитов/мерозоитов eimeria maxima, и их применения |
| ITMI20011986A1 (it) | 2001-09-25 | 2003-03-25 | San Raffaele Centro Fond | Metodo e composizione per l'attivazione di cellule presentanti l'antigene |
| WO2003028441A1 (en) | 2001-10-02 | 2003-04-10 | The Board Of Trustees Of The Leland Stanford Junior University | Gene therapy for the prevention of autoimmune disease |
| ATE399180T1 (de) * | 2001-12-21 | 2008-07-15 | Immunex Corp | Rekombinante polypeptide |
| EP1487273B1 (en) * | 2002-02-13 | 2009-01-21 | Immunology Laboratories, Inc. | Compositions and methods for treatment of microbial infections |
| US6923958B2 (en) * | 2002-03-02 | 2005-08-02 | The Scripps Research Institute | DNA vaccines encoding CEA and a CD40 ligand and methods of use thereof |
| EP1499191B1 (en) * | 2002-04-15 | 2012-05-09 | Washington University in St. Louis | Regulated attenuation of live vaccines to enhance cross protective immunogenicity |
| US7495090B2 (en) | 2002-05-23 | 2009-02-24 | The Regents Of The University Of California | Nucleic acids encoding chimeric CD154 polypeptides |
| US20050181994A1 (en) * | 2003-01-06 | 2005-08-18 | Xencor, Inc. | Novel variants of CD40L protein |
| US20060014248A1 (en) * | 2003-01-06 | 2006-01-19 | Xencor, Inc. | TNF super family members with altered immunogenicity |
| US7754209B2 (en) * | 2003-07-26 | 2010-07-13 | Trubion Pharmaceuticals | Binding constructs and methods for use thereof |
| WO2005035570A2 (en) | 2003-10-10 | 2005-04-21 | Xencor, Inc. | Variants of cd40l protein |
| EP1720905A2 (en) | 2003-12-11 | 2006-11-15 | Sidney Kimmel Cancer Center | Methods for generating immunity to antigen |
| US8828957B2 (en) * | 2003-12-11 | 2014-09-09 | Microvax, Llc | Methods for generating immunity to antigen |
| WO2005113598A2 (en) | 2004-05-21 | 2005-12-01 | Xencor, Inc. | Tnf super family members with altered immunogenicity |
| KR101243577B1 (ko) * | 2004-10-07 | 2013-03-20 | 아고스 쎄라퓨틱스, 인코포레이티드 | 성숙 수지상 세포 조성물 및 그의 배양 방법 |
| US8513008B2 (en) * | 2004-10-07 | 2013-08-20 | Argos Therapeutics, Inc. | Mature dendritic cell compositions and methods for culturing same |
| WO2006105972A1 (en) | 2005-04-07 | 2006-10-12 | Universite Libre De Bruxelles | Transgenic organism expressing cd40l and uses thereof |
| WO2006130525A2 (en) * | 2005-05-31 | 2006-12-07 | Sidney Kimmel Cancer Center | Methods for immunotherapy of cancer |
| SI1949913T1 (sl) | 2005-10-07 | 2011-02-28 | Proyecto Biomedicina Cima Sl | Imunsko stimulacijska kombinacija za zaĺ äśito in zdravljenje hepatitisa c |
| US9533036B2 (en) * | 2005-11-07 | 2017-01-03 | Microvax, Llc | Methods for generating immune responses to influenza antigens with a secretable CD40L fusion protein |
| DE102005054643B3 (de) | 2005-11-10 | 2007-02-15 | Assa Abloy Sicherheitstechnik Gmbh | Schließzylinder |
| WO2007054658A1 (en) | 2005-11-14 | 2007-05-18 | King's College London | Control of immune responses |
| CU23576A1 (es) * | 2006-02-28 | 2010-09-30 | Ct Ingenieria Genetica Biotech | Antígenos vacunales quiméricos contra el virus de la influenza aviar |
| WO2007103048A2 (en) * | 2006-03-01 | 2007-09-13 | Regents Of The University Of Colorado | Tlr agonist (flagellin)/cd40 agonist/antigen protein and dna conjugates and use thereof for inducing synergistic enhancement in immunity |
| US8802419B2 (en) * | 2006-03-02 | 2014-08-12 | University Of Massachusetts | Modified pathogens for use as vaccines |
| FR2898905B1 (fr) * | 2006-03-24 | 2008-05-09 | Rhodia Recherches & Tech | Composition polyisocyanate a proprietes anti-chocs ameliorees |
| US20090246220A1 (en) * | 2006-08-28 | 2009-10-01 | Ertl Hildegund C J | Constructs for enhancing immune responses |
| PT2066339E (pt) * | 2006-09-18 | 2014-10-31 | Texas A & M Univ Sys | Composições e métodos de potenciar respostas imunes |
| WO2008109825A2 (en) | 2007-03-08 | 2008-09-12 | Mayo Foundation For Medical Education And Research | Inducing immune-mediated tumor cell death |
| CN101024076B (zh) * | 2007-03-29 | 2010-08-18 | 中国农业大学 | 球虫的新用途 |
| ES2560871T3 (es) * | 2007-07-10 | 2016-02-23 | Apogenix Gmbh | Proteínas de fusión de colectina de la superfamilia de TNF |
| WO2009059018A1 (en) | 2007-10-30 | 2009-05-07 | The Board Of Trustees Of The University Of Arkansas | Compositions and methods of enhancing immune responses to flagellated bacterium |
| HUE047164T2 (hu) * | 2007-11-01 | 2020-04-28 | Univ Arkansas | Kompozíciók és eljárások eimeria elleni immunválasz fokozására |
| JP5674155B2 (ja) * | 2008-07-21 | 2015-02-25 | アポゲニクス ゲゼルシャフト ミット ベシュレンクテル ハフツングＡｐｏｇｅｎｉｘ ＧｍｂＨ | Ｔｎｆｓｆ一本鎖分子 |
| US8316310B2 (en) | 2008-08-05 | 2012-11-20 | International Business Machines Corporation | System and method for human identification proof for use in virtual environments |
| EP2184229B1 (en) * | 2008-11-11 | 2012-10-17 | AGUSTAWESTLAND S.p.A. | Helicopter rotor |
| US20100150958A1 (en) * | 2008-12-15 | 2010-06-17 | Vectogen Pty Ltd. | Methods and Compositions for Use of a Coccidiosis Vaccine |
| NO2525817T3 (cg-RX-API-DMAC7.html) * | 2010-01-21 | 2018-01-06 | ||
| EP2771022B1 (en) * | 2011-10-11 | 2020-07-01 | Viela Bio, Inc. | Cd40l-specific tn3-derived scaffolds and methods of use thereof |
| US20140079704A1 (en) * | 2012-09-11 | 2014-03-20 | The Texas A&M University System | BI-Specific Diabodies For Masking And Targeting Vaccines |
| WO2014070709A1 (en) * | 2012-10-29 | 2014-05-08 | The Board Of Trustees Of The University Of Arkansas | Novel mucosal adjuvants and delivery systems |
| EP2956165B1 (en) * | 2013-02-14 | 2019-09-11 | The Board of Trustees of the University of Arkansas | Compositions and methods of enhancing immune responses to eimeria or limiting eimeria infection |
| AR095313A1 (es) * | 2013-03-15 | 2015-10-07 | Univ Arkansas | Composiciones y métodos para aumentar la respuesta inmune contra patógenos entéricos |
| MX2016016080A (es) * | 2014-06-05 | 2017-05-09 | Univ Arkansas | Vacunas guiadas por anticuerpos y metodos de uso para generar respuestas imunitarias maduras rapidas. |
| US20160090603A1 (en) * | 2014-09-30 | 2016-03-31 | Sandia Corporation | Delivery platforms for the domestication of algae and plants |
| EP3436070A4 (en) * | 2016-03-29 | 2019-11-27 | University of Southern California | AGAINST CANCER, CHIMERIC ANTIGEN RECEPTORS |
| PT3464361T (pt) * | 2016-05-27 | 2021-12-27 | Abbvie Biotherapeutics Inc | Anticorpos anti-cd40 e suas utilizações |
| EP3500585A4 (en) * | 2016-08-17 | 2020-04-01 | Factor Bioscience Inc. | NUCLEIC ACID PRODUCTS AND METHODS OF ADMINISTRATION |
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