DK2205964T3 - Multiområde- og potentialtestsensorer, fremgangsmåder og systemer - Google Patents

Multiområde- og potentialtestsensorer, fremgangsmåder og systemer Download PDF

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Publication number
DK2205964T3
DK2205964T3 DK08832808.3T DK08832808T DK2205964T3 DK 2205964 T3 DK2205964 T3 DK 2205964T3 DK 08832808 T DK08832808 T DK 08832808T DK 2205964 T3 DK2205964 T3 DK 2205964T3
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electrode
test sensor
electrodes
sample
potential
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DK08832808.3T
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Weiping Zhong
Huan-Ping Wu
Joseph E Perry
Eric Maurer
Sung-Kwon Jung
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Bayer Healthcare Llc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Electrochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
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  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measurement Of Current Or Voltage (AREA)

Claims (13)

  1. - _L -
    1. Analyttestsensor (700), der omfatter: mindst to substrater, der danner et reservoir, hvilket 5 reservoir har et primært område (710) mellem otte i det væsentlige kemisk isolerede sekundære analyseområder, hvor der i det væsentlige ikke forekommer diffusions- eller konvektionsblanding af reagenser mellem de sekundære analyseområder i løbet af tidsrummet for den ene eller de 10 flere analyser; fire arbejdselektroder (841-844), der hver inkluderer en første leder og en reagenssammensætning, der er disponeret i separate sekundære analyseområder, hvor hver arbejdselektrode (841-844) har mindst én reagenssammensætning med et anderledes 15 redoxpotentiale; og fire modelektroder (731-734), der hver inkluderer en anden leder og mindst én redoxart, der er disponeret i separate sekundære analyseområder; hvor de første ledere på arbejdselektroderne (841-844) er 20 elektrisk forbundet, hvor de andre ledere på modelektroderne (731-734) ikke er elektrisk forbundet og er uafhængigt addresserbare.
  2. 2. Testsensor ifølge krav 1, hvor det primære område (710) i 25 alt væsentligt adskiller de i det væsentlige kemisk isolerede sekundære områder.
  3. 3. Testsensor ifølge krav 2, hvor de sekundære analyseområder er anbragt forskudt på modsatte sider af det 3 0 primære område (710) .
  4. 4. Testsensor ifølge krav 3, hvor de sekundære analyseområder forgrener sig fra det primære område (710) i en vinkel på 90°. 35
  5. 5. Testsensor ifølge et hvilket som helst af ovennævnte krav, hvor hvert sekundære analyseområde har én elektrode. Δ* —
  6. 6. Testsensor ifølge krav 2, hvor de fire arbejdselektroder (841-844) er disponeret i sekundære analyseområder på den ene side af det primære område (710), og hvor de fire modelektroder (731-734) er disponeret i sekundære 5 analyseområder på den anden side af det primære område (710).
  7. 7. Testsensor ifølge et hvilket som helst af ovennævnte krav, der yderligere er kendetegnet ved en anden leder (790), der er forbundet til den ene af modelektroderne (731-734) og 10 strækker sig ind i det primære område (710).
  8. 8. Testsensor ifølge et hvilket som helst af ovennævnte krav, hvor modelektroderne (731-734) er konfigureret til at operere ved forskellige potentialer med intervaller på mindst 15 5 0 mV.
  9. 9. Testsensor ifølge et hvilket som helst af ovennævnte krav, hvor redoxarten er udvalgt fra gruppen, der består af et metal mod et elektroaktivt organisk molekyle og 20 grundstofidentiteten af et metal.
  10. 10. Testsensor ifølge et hvilket som helst af kravene 1 til 8, hvor den anderledes potentialekonfiguration tilvejebringes af redoxarter med forskellige forhold mellem konjugaterne i et 25 redoxpar.
  11. 11. Testsensor ifølge et hvilket som helst af ovennævnte krav, der yderligere er kendetegnet ved mindst én referenceelektrode (770) i det primære område (710). 30
  12. 12. Testsensor ifølge et hvilket som helst af ovennævnte krav, hvor reagenssammensætningen inkluderer et enzymsystem, en mediator og et bindemiddel; og 35 hvor hver modelektrode (731-734) i det væsentlige består af den anden leder, den mindst ene redoxart og et bindemiddel.
  13. 13. Testsensor ifølge krav 1, hvor hver arbejdselektrode - J - (841-844) har to eller fire reagenssammensætninger med forskellige redoxpotentialer.
DK08832808.3T 2007-09-24 2008-09-24 Multiområde- og potentialtestsensorer, fremgangsmåder og systemer DK2205964T3 (da)

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US97482307P 2007-09-24 2007-09-24
PCT/US2008/077434 WO2009042631A2 (en) 2007-09-24 2008-09-24 Multi-electrode test sensors

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US (2) US9846136B2 (da)
EP (7) EP3660499A1 (da)
JP (4) JP5523323B2 (da)
CN (3) CN101849180B (da)
BR (1) BRPI0817189A2 (da)
CA (3) CA2984510C (da)
DK (1) DK2205964T3 (da)
ES (5) ES2547493T3 (da)
HR (1) HRP20150979T1 (da)
MX (1) MX2010003205A (da)
PL (4) PL2535705T3 (da)
RU (1) RU2490622C2 (da)
WO (1) WO2009042631A2 (da)

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