DK2132317T3 - Delta-8-desaturaser og anvendelse heraf i fremstillingen af polyumættede fedtsyrer - Google Patents

Delta-8-desaturaser og anvendelse heraf i fremstillingen af polyumættede fedtsyrer

Info

Publication number
DK2132317T3
DK2132317T3 DK08742773.8T DK08742773T DK2132317T3 DK 2132317 T3 DK2132317 T3 DK 2132317T3 DK 08742773 T DK08742773 T DK 08742773T DK 2132317 T3 DK2132317 T3 DK 2132317T3
Authority
DK
Denmark
Prior art keywords
desaturases
delta
preparation
fatty acids
polyunsaturated fatty
Prior art date
Application number
DK08742773.8T
Other languages
Danish (da)
English (en)
Inventor
Howard Glenn Damude
Quinn Qun Zhu
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Application granted granted Critical
Publication of DK2132317T3 publication Critical patent/DK2132317T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
DK08742773.8T 2007-04-10 2008-04-10 Delta-8-desaturaser og anvendelse heraf i fremstillingen af polyumættede fedtsyrer DK2132317T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91083107P 2007-04-10 2007-04-10
PCT/US2008/004700 WO2008124194A1 (en) 2007-04-10 2008-04-10 Delta-8 desaturases and their use in making polyunsaturated fatty acids

Publications (1)

Publication Number Publication Date
DK2132317T3 true DK2132317T3 (da) 2013-06-03

Family

ID=39708314

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08742773.8T DK2132317T3 (da) 2007-04-10 2008-04-10 Delta-8-desaturaser og anvendelse heraf i fremstillingen af polyumættede fedtsyrer

Country Status (9)

Country Link
US (5) US8188338B2 (enExample)
EP (2) EP2132317B1 (enExample)
JP (1) JP5501952B2 (enExample)
CN (1) CN101679990B (enExample)
AU (2) AU2008237065A1 (enExample)
BR (1) BRPI0808222A2 (enExample)
CA (2) CA2683497C (enExample)
DK (1) DK2132317T3 (enExample)
WO (2) WO2008124194A1 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8188338B2 (en) 2007-04-10 2012-05-29 E. I. Du Pont De Nemours And Company Delta-8 desaturases and their use in making polyunsaturated fatty acids
US7794701B2 (en) * 2007-04-16 2010-09-14 E.I. Du Pont De Nemours And Company Δ-9 elongases and their use in making polyunsaturated fatty acids
JP5711968B2 (ja) * 2007-10-03 2015-05-07 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ 高エイコサペンタエン酸を生成するためのヤロウィア・リポリティカ（ＹａｒｒｏｗｉａＬｉｐｏｌｙｔｉｃａ）の最適化株
DK2442666T3 (da) 2009-06-16 2015-07-13 Du Pont Olier med højt indhold af eicosapentaensyre fra forbedrede og optimerede stammer af yarrowia lipolytica
DK2496092T3 (en) 2009-11-03 2018-07-16 Dsm Ip Assets Bv COMPOSITION WITH CELLS AND A POLYUM Saturated FAT ACID WITH AT LEAST 20 CARBON ATOMS (LC-PUFA)
AU2010317140B2 (en) 2009-11-03 2016-04-21 Dsm Ip Assets B.V. Vegatable oil comprising a polyunsaturaded fatty acid having at least 20 carbon atoms
EP2561050A1 (en) 2010-04-22 2013-02-27 E.I. Du Pont De Nemours And Company Method for obtaining polyunsaturated fatty acid-containing compositions from microbial biomass
EP2609202A1 (en) 2010-08-26 2013-07-03 E.I. Du Pont De Nemours And Company Mutant hpgg motif and hdash motif delta-5 desaturases and their use in making polyunsaturated fatty acids
CN103249834B (zh) 2010-08-26 2016-10-26 纳幕尔杜邦公司 生产高水平二十碳五烯酸的重组微生物宿主细胞
US8980589B2 (en) 2010-08-26 2015-03-17 E I Du Pont De Nemours And Company Mutant delta-9 elongases and their use in making polyunsaturated fatty acids
JP2014503216A (ja) 2010-12-30 2014-02-13 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー スクロース利用のための、ヤロウィア・リポリティカ（Ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）におけるサッカロミセス・セレビシア（Ｓａｃｃｈａｒｏｍｙｃｅｓｃｅｒｅｖｉｓｉａｅ）ＳＵＣ２遺伝子の使用
US20130040340A1 (en) 2011-02-07 2013-02-14 E. I. Du Pont De Nemours And Company Production of alcohol esters in situ using alcohols and fatty acids produced by microorganisms
US9005940B2 (en) 2012-12-21 2015-04-14 E I Du Pont De Nemours And Company Down-regulation of a polynucleotide encoding a Sou2 sorbitol utilization protein to modify lipid production in microbial cells
BR112015023285B1 (pt) 2013-03-14 2022-03-03 Pioneer Hi-Bred International, Inc. Cassete de expressão, célula hospedeira bacteriana e método para controlar uma praga de planta do tipo coleóptero
CA2901316A1 (en) 2013-03-15 2014-09-25 Pioneer Hi-Bred International, Inc. Phi-4 polypeptides and methods for their use
MX359026B (es) 2013-08-16 2018-09-12 Pioneer Hi Bred Int Proteinas insecticidas y metodos de uso.
US10667524B2 (en) 2013-09-13 2020-06-02 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
WO2015120270A1 (en) 2014-02-07 2015-08-13 Pioneer Hi Bred International, Inc. Insecticidal proteins and methods for their use
UA120608C2 (uk) 2014-02-07 2020-01-10 Піонір Хай-Бред Інтернешнл, Інк. Очищений поліпептид ptip-83 та спосіб його застосування
CA2961733A1 (en) 2014-09-17 2016-03-24 Pioneer Hi-Bred International, Inc. Compositions and methods to control insect pests
CN107108705B (zh) 2014-10-16 2021-05-25 先锋国际良种公司 杀昆虫蛋白及其使用方法
EP3244727B1 (en) 2015-01-15 2025-10-22 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
RU2017144238A (ru) 2015-05-19 2019-06-19 Пайонир Хай-Бред Интернэшнл, Инк. Инсектицидные белки и способы их применения
WO2016205445A1 (en) 2015-06-16 2016-12-22 Pioneer Hi-Bred International, Inc. Compositions and methods to control insect pests
CN109475096B (zh) 2015-08-06 2022-08-23 先锋国际良种公司 植物来源的杀昆虫蛋白及其使用方法
DK3341483T3 (da) 2015-08-28 2020-03-16 Pioneer Hi Bred Int Ochrobactrum-medieret transformation af planter
CN105137844B (zh) * 2015-08-31 2017-09-01 广东电网有限责任公司电力科学研究院 锅炉调试过程中风险预控方法和系统
CN108575091A (zh) 2015-12-18 2018-09-25 先锋国际良种公司 杀昆虫蛋白及其使用方法
EA201892293A1 (ru) 2016-05-04 2019-04-30 Пайонир Хай-Бред Интернэшнл, Инк. Инсектицидные белки и способы их применения
BR112018076047A2 (pt) 2016-06-16 2019-03-26 Pioneer Hi Bred Int elemento de silenciamento, construto de dna, cassete de expressão, célula hospedeira, composição, célula vegetal, planta ou parte de planta, semente transgênica, método para controlar um inseto-praga de planta e kit
CA3026113A1 (en) 2016-07-01 2018-01-04 Pioneer Hi-Bred International, Inc. Insecticidal proteins from plants and methods for their use
WO2018013333A1 (en) 2016-07-12 2018-01-18 Pioneer Hi-Bred International, Inc. Compositions and methods to control insect pests
EP3535285B1 (en) 2016-11-01 2022-04-06 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
EP3554265A1 (en) 2016-12-15 2019-10-23 DSM IP Assets B.V. Blend formulation comprising silicate and microbial and / or plant cells comprising a polyunsaturated fatty acid having at least 20 carbon atoms (lc-pufa)
EP3764798B1 (en) 2018-03-14 2025-12-17 Pioneer Hi-Bred International, Inc. Insecticidal proteins from plants and methods for their use
EP3764796B1 (en) 2018-03-14 2025-12-03 Pioneer Hi-Bred International, Inc. Insecticidal proteins from plants and methods for their use
CA3186978A1 (en) 2020-07-14 2022-01-20 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4670285A (en) 1982-08-06 1987-06-02 The University Of Toronto Innovations Foundation Infant formula
US5188958A (en) 1986-05-29 1993-02-23 Calgene, Inc. Transformation and foreign gene expression in brassica species
US5004863B2 (en) 1986-12-03 2000-10-17 Agracetus Genetic engineering of cotton plants and lines
US5416011A (en) 1988-07-22 1995-05-16 Monsanto Company Method for soybean transformation and regeneration
US6372965B1 (en) 1992-11-17 2002-04-16 E.I. Du Pont De Nemours And Company Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants
IL132148A0 (en) 1997-04-11 2001-03-19 Calgene Llc Methods and compositions for synthesis of long chain polyunsaturated fatty acids in plants
US6051754A (en) 1997-04-11 2000-04-18 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants
US6432684B1 (en) 1997-04-11 2002-08-13 Abbott Laboratories Human desaturase gene and uses thereof
US6075183A (en) 1997-04-11 2000-06-13 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants
US5968809A (en) 1997-04-11 1999-10-19 Abbot Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
US5972664A (en) 1997-04-11 1999-10-26 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
US6403349B1 (en) 1998-09-02 2002-06-11 Abbott Laboratories Elongase gene and uses thereof
CA2791961A1 (en) 1998-12-07 2000-06-15 Washington State University Research Foundation Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
US6825017B1 (en) * 1998-12-07 2004-11-30 Washington State University Research Foundation Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
ATE360075T1 (de) 2000-07-21 2007-05-15 Du Pont Ein mit der synthese von delta-12 epoxy-gruppen in fettsäuren von pflanzen assoziiertes cytochrom p450 enzym
GB0107510D0 (en) 2001-03-26 2001-05-16 Univ Bristol New elongase gene and a process for the production of -9-polyunsaturated fatty acids
TWI324181B (en) 2001-04-16 2010-05-01 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
AU2003296638B2 (en) 2002-12-19 2009-06-11 University Of Bristol Method for the production of polyunsaturated fatty acids
US20040172682A1 (en) 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
US7238482B2 (en) * 2003-05-07 2007-07-03 E. I. Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
US7125672B2 (en) * 2003-05-07 2006-10-24 E. I. Du Pont De Nemours And Company Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
US7259255B2 (en) 2003-06-25 2007-08-21 E. I. Du Pont De Nemours And Company Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast
EP1682566B1 (en) 2003-11-12 2013-06-05 E.I. Du Pont De Nemours And Company Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous plants and yeast
WO2005049805A2 (en) 2003-11-14 2005-06-02 E.I. Dupont De Nemours And Company Fructose-bisphosphate aldolase regulatory sequences for gene expression in oleaginous yeast
CA3023314C (en) 2004-04-22 2019-12-10 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
CN103451246B (zh) * 2004-04-22 2018-02-16 联邦科学技术研究组织 用重组细胞合成长链多不饱和脂肪酸
WO2006012325A1 (en) 2004-06-25 2006-02-02 E.I. Dupont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
US7465564B2 (en) * 2004-08-10 2008-12-16 E.I. Du Pont De Nemours And Company Production of γ-linolenic acid in oleaginous yeast
US7588931B2 (en) 2004-11-04 2009-09-15 E. I. Du Pont De Nemours And Company High arachidonic acid producing strains of Yarrowia lipolytica
KR20080071190A (ko) 2005-11-23 2008-08-01 이 아이 듀폰 디 네모아 앤드 캄파니 델타-９ 일롱가제, 및 다중불포화 지방산 생성에 있어서의이들의 용도
US7943823B2 (en) * 2006-04-28 2011-05-17 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
US7678560B2 (en) 2006-05-17 2010-03-16 E.I. Du Pont De Nemours And Company Δ 5 desaturase and its use in making polyunsaturated fatty acids
CA2663768A1 (en) * 2006-10-23 2008-05-29 E. I. Du Pont De Nemours And Company Delta-8 desaturases and their use in making polyunsaturated fatty acids
US7709239B2 (en) * 2006-12-07 2010-05-04 E.I. Du Pont De Nemours And Company Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids
WO2008073275A2 (en) 2006-12-07 2008-06-19 E. I. Du Pont De Nemours And Company Mutant delta-8 desaturase genes engineered by targeted mutagensis and their use in making polyunsaturated fatty acids
UA102063C2 (uk) * 2007-02-12 2013-06-10 Е. І. Дю Пон Де Немур Енд Компані Трансгенна соєва рослина, що продукує арахідонову кислоту
US8188338B2 (en) * 2007-04-10 2012-05-29 E. I. Du Pont De Nemours And Company Delta-8 desaturases and their use in making polyunsaturated fatty acids

Also Published As

Publication number Publication date
CN101679990B (zh) 2013-06-19
AU2008237065A1 (en) 2008-10-16
US20080254521A1 (en) 2008-10-16
WO2008124806A3 (en) 2010-07-22
US20100267099A1 (en) 2010-10-21
US8338152B2 (en) 2012-12-25
CN101679990A (zh) 2010-03-24
AU2008236595A1 (en) 2008-10-16
AU2008236595B2 (en) 2013-06-13
WO2008124806A2 (en) 2008-10-16
US7790156B2 (en) 2010-09-07
CA2683497A1 (en) 2008-10-16
BRPI0808222A2 (pt) 2014-07-08
US8318463B2 (en) 2012-11-27
EP2132317A1 (en) 2009-12-16
CA2681145A1 (en) 2008-10-16
US20080254192A1 (en) 2008-10-16
CA2683497C (en) 2015-08-11
JP5501952B2 (ja) 2014-05-28
EP2121737A2 (en) 2009-11-25
EP2132317B1 (en) 2013-02-27
US20120196347A1 (en) 2012-08-02
CA2681145C (en) 2016-02-16
US8188338B2 (en) 2012-05-29
WO2008124194A1 (en) 2008-10-16
US20100099900A1 (en) 2010-04-22
JP2010523147A (ja) 2010-07-15
EP2121737B1 (en) 2015-05-27

Similar Documents

Publication Publication Date Title
DK2259674T3 (da) Delta-4-desaturase og anvendelse heraf i fremstillingen af flerumættedefedtsyrer
GB0915693D0 (en) Fatty acid formulations and methods of use thereof
DK2840131T3 (da) Fremstilling af fedtsyrer og derivater deraf
ZA201003030B (en) Medium-chain length fatty acids and glycerides as nephroprotection agents
PL2395991T3 (pl) Zastosowanie estru etylowego kwasu eikozapentaenowego do leczenia hipertriglicerydemii
LT2315740T (lt) Acetilinti riebalų rūgščių salicilatai ir jų panaudojimas
DK2424520T3 (da) Anvendelse af flerumættede fedtsyrer til behandling af hudinflammation
IL240454A0 (en) Propanesulfonic acids and their 1-amino-3 use in the preparation of medicines
EP2324119A4 (en) DELTA5 MUTANT DESATURASES AND THEIR USE IN PRODUCTION OF POLYUNSATURATED FATTY ACIDS
EP2197289A4 (en) SOLID FAT COMPOSITIONS CONTAINING MULTIPLE UNSATURATED FATTY ACIDS AND THEIR USES AND MANUFACTURING
PL2390339T3 (pl) Delta-8 desaturazy i ich zastosowanie w wytwarzaniu polinienasyconych kwasów tłuszczowych
PT2099321T (pt) Composições de leite humano e métodos de fabrico e utilização das mesmas
SI3725330T1 (sl) Stabilne formulacije polipeptidov in njihova uporaba
BRPI0811871A2 (pt) Composições agroquímicas ácidas bioativas e uso das mesmas
DK2034999T3 (da) DHA-estere og anvendelse deraf i behandlingen og forebyggelsen af cardiovaskulære sygdomme
SI2084151T1 (sl) Substituirani dihidropirazoloni za zdravljenje kardiovaskularnih in hematoloških bolezni
BRPI0911656A2 (pt) formulações de nanopartículas e usos das mesmas
AP2657A (en) Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
SI3202898T1 (sl) Terapevtski sestavki nukleaze in postopki
PL2049097T3 (pl) Kompozycja i sposób wiązania aldehydu octowego w żołądku
ATE541560T1 (de) Zusammensetzung mit mehrfach ungesättigten fettsäuren und aktivierter holzkohle
GB2464886B (en) Preparation of fatty acids in solid form
BRPI1010075A2 (pt) ''núcleo absorvente e artigo absorvente''
ZA201001473B (en) Compositions and methods for the modification of physiological responses in plants
EP2490542A4 (en) DERMATOLOGICAL AND COSMETIC COMPOSITIONS