DK2124603T3 - Mælkeproteinhydrolysater med reduceret immunogent potentiale - Google Patents

Mælkeproteinhydrolysater med reduceret immunogent potentiale Download PDF

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DK2124603T3
DK2124603T3 DK07862429.3T DK07862429T DK2124603T3 DK 2124603 T3 DK2124603 T3 DK 2124603T3 DK 07862429 T DK07862429 T DK 07862429T DK 2124603 T3 DK2124603 T3 DK 2124603T3
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seq
hydrolyzate
protein
enriched
endopeptidase
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DK07862429.3T
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Manoj Kumar
David Wong
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Dupont Nutrition Biosci Aps
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
    • A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C21/00—Whey; Whey preparations
    • A23C21/02—Whey; Whey preparations containing, or treated with, microorganisms or enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/1203—Addition of, or treatment with, enzymes or microorganisms other than lactobacteriaceae
    • A23C9/1209—Proteolytic or milk coagulating enzymes, e.g. trypsine
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21019—Glutamyl endopeptidase (3.4.21.19)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Dairy Products (AREA)

Claims (28)

1. Hydrolysat, der omfatter mindst ét mælkeprotein, der er hydrolyseret med mindst ét proteolytisk enzym, som fortrinsvis spalter ved en glutaminsyre- eller asparaginsyrerest, og som spalter én eller flere immunologiske determinanter, der er til stede i proteinet, hvilket hydrolysat omfatter mindst en beta-lactoglobulin, der er hydrolyseret i området mellem aminosyrerne 55-98, hvilket hydrolysat har reduceret immunogenicitet i et individ, der er prædisponeret for at få en immunreaktion mod proteinet, og hvor hydrolysatet er beriget med mindst peptidet AQSAPLRVYVE (SEQ ID NO: 1), hvor mindst ét proteolytisk enzym er en endopeptidase, og hvor endopeptidasen ikke er én, der har aminosyresekvensen: 5 10 15 20 25 30 ISVIGSDDRTRVTNTTA*PYRAIVHISSSIG 31 SCTGWMIGPKTVATAGH CIYOTSSGS FAGT 61ATVSPGRRCT5YPYGSVXSTRYFIPSGWRS 91 G » t N V D Y (U I E L S E f I C Η V C ϊ Γ G Ϊ S Ϊ t T S m S L V G T ΐ v Π S G r’P C D K T 1 C T 0 # 0 H S O P I u 1S1 SETYKtQYAMDtYCG0S6SPVF£QS55KTH ISlCSGPCSfAVHTNGVYGGSSyNRGTRITXBV 211 FOWLTNWKNSAQ
2. Hydrolysat ifølge krav 1, hvor endopeptidasen fortrinsvis spalter på den carboxyterminale side af en glutaminsyrerest eller en asparaginsyrerest.
3. Hydrolysat ifølge krav 2, hvor endopeptidasen er UniProtKB/Swiss-Prot primært accessionsnummer P39790.
4. Hydrolysat, der omfatter mindst ét mælkeprotein, der er hydrolyseret med mindst ét proteolytisk enzym, der fortrinsvis spalter ved en glutaminsyre- eller asparaginsyrerest, hvor det proteolytiske enzym er endopeptidasen UniProtKB/Swiss-Prot primært accessionsnummer P39790, hvilket hydrolysat har reduceret immunogenicitet i et individ, der er prædisponeret for at få en immunreaktion mod proteinet, og hvor hydrolysatet er beriget med mindst peptidet AQSAPLRVYVE (SEQ ID NO: 1).
5. Hydrolysat ifølge et hviket som helst af kravene 3-4 hvor endopeptidasen inhiberes af phenylmethylsulfonylfluorid eller diisopropylfluorphosphat.
6. Hydrolysat ifølge krav 1, hvor proteinet er et opløseligt, ikke-micellært protein.
7. Hydrolysat ifølge krav 6, hvor proteinet er valleprotein.
8. Hydrolysat ifølge krav 7, hvor endopeptidasen ikke kræver en metal-ion for dens aktivitet.
9. Hydrolysat ifølge krav 7, hvor proteinet inkluderer mindst én af en lactalbumin, fortrinsvis en alfa-lactalbumin.
10. Hydrolysat ifølge krav 9, hvor proteinet er mindst én af en lactalbumin eller en lactoglobulin, fortrinsvis en alfa-lactalbumin eller en beta-lactoglobulin.
11. Hydrolysat ifølge krav 10, hvor hydrolysatet er beriget med et eller flere af peptiderne ILLQKWE (SEQ ID NO: 2), KTKIPAVFKID (SEQ ID NO: 3) eller KTKIPAVFKIDALNE (SEQ ID NO: 4) .
12. Hydrolysat ifølge krav 1, som er beriget med peptider, der terminerer i en glutaminsyre- eller asparaginsyrerest, sammenlignet med det uhydrolyserede protein.
13. Hydrolysat ifølge krav 12, som er beriget med et eller flere af peptiderne ELEE (SEQ ID NO: 5), VATEE (SEQ ID NO: 6), PFTE (SEQ ID NO: 7), NSAEPE (SEQ ID NO: 8), VFGKE (SEQ ID NO:
9), ILLQKWE (SEQ ID NO: 2), KTKIPAVFKID (SEQ ID NO: 3), KTKIPAVFKIDALNE (SEQ ID NO: 4), IQPTPE (SEQ ID NO: 10), LKPTPE (SEQ ID NO: 11), LKPTPEGD (SEQ ID NO: 12), LKPTPEGDLE (SEQ ID NO: 13), TKIPAVFKID (SEQ ID NO: 14) eller TKI PAVFKI DALNE (SEQ ID NO: 15).
14. Hydrolysat ifølge krav 12, som er beriget med et eller flere af peptiderne DQAME (SEQ ID NO: 16), GIHAQQKE (SEQ ID NO: 17), VLNE (SEQ ID NO: 18), VFGKE (SEQ ID NO: 19), RLHSMKE (SEQ ID NO: 20), DIKQME (SEQ ID NO: 21), KHPIKHQGLPQE (SEQ ID NO: 22), RPKHPIKHQGLPQE (SEQ ID NO: 23), PMIGVNQE (SEQ ID NO: 24), GIHAQQKEPMEGVNQE (SEQ ID NO: 25), RYLGYLE (SEQ ID NO: 26), LAYFYPE (SEQ ID NO: 27), FVAPFPE (SEQ ID NO: 28), KTTMPLW (SEQ ID NO: 29), LFRQFYQLD (SEQ ID NO: 30), F FVAPFPE (SEQ ID NO: 31), NLLRFFV APFPE (SEQ ID NO: 32) eller ENLLRFFVAPFPE (SEQ ID NO: 33) .
15. Valleproteinholdigt hydrolysat, som er beriget med AQSAPLRVYVE (SEQ ID NO: 1).
16. Valleproteinholdigt hydrolysat ifølge krav 15, hvor hydrolysatet er beriget med et eller flere af peptiderne ILLQKWE (SEQ ID NO: 2), KTKIPAVFKID (SEQ ID NO: 3) eller KTKIPAVFKIDALNE (SEQ ID NO: 4).
17. Fødevareingrediens, der omfatter et valleproteinhydrolysat, som er beriget med AQSAPLRVYVE (SEQ ID NO: 1), der har reduceret immunogenicitet i et individ, der er prædisponeret for at få en immunreaktion mod et eller flere valleproteiner.
18. Fødevareingrediens ifølge krav 17, hvor hydrolysatet er beriget med et eller flere af peptiderne ILLQKWE (SEQ ID NO: 2), KTKIP A VFKID (SEQ ID NO: 3) eller KTKIPAVFKIDALNE (SEQ ID NO: 4) .
19. Forarbejdet fødevareprodukt, der omfatter et valleproteinhydrolysat, som er beriget med AQSAPLRVYVE (SEQ ID NO: 1), der har reduceret immunogenicitet i et individ, der er prædisponeret for at få en immunreaktion mod et eller flere valleproteiner.
20. Forarbejdet fødevareprodukt ifølge krav 19, hvor hydrolysatet er beriget med et eller flere af peptiderne ILLQKWE (SEQ ID NO: 2), KTKIPAVFKID (SEQ ID NO: 3) eller KTKIPAVFKIDALNE (SEQ ID NO: 4).
21. Forarbejdet fødevareprodukt ifølge krav 19 eller krav 20, som er en modermælkserstatning, en sportsdrik, et osteholdigt produkt, et proteintilskud, et ernæringstilskud eller et måltidserstatningsprodukt.
22. Nonfood-produkt, der omfatter et hydrolysat ifølge krav 1 eller krav 4, hvor nonfood-produktet er kosmetik, en lotion eller et renseprodukt til anvendelse på human hud.
23. Nonfood-produkt, der omfatter et hydrolysat, der omfatter mindst ét mælkeprotein, der er hydrolyseret med mindst ét proteolytisk enzym, der fortrinsvis spalter ved en glutaminsyre- eller asparaginsyrerest, hvilket hydrolysat omfatter mindst en beta-lactoglobulin, der er hydrolyseret i området mellem aminosyrerne 55-98, hvilket hydrolysat har reduceret immunogenicitet i et individ, der er prædisponeret for at få en immunreaktion mod proteinet, og hvor hydrolysatet er beriget med mindst peptidet AQSAPLRVYVE (SEQ ID NO: 1).
24. Nonf ood-produkt ifølge krav 22 eller krav 23, der omfatter et valleproteinhydrolysat, der er beriget med et eller flere af peptiderne AQSAPLRVYVE (SEQ ID NO: 1), ILLQKWE (SEQ ID NO: 2), KTKIPAVFKID (SEQ ID NO: 3) eller KTKIPAVFKIDALNE (SEQ ID NO: 4), der har reduceret immunogenicitet i et individ, der er prædisponeret for at få en immunreaktion mod et eller flere valleproteiner.
25. Sammensætning, der omfatter mindst to hydrolysater ifølge krav 1 eller krav 4, hvor hvert hydrolysat frembringes med mindst ét andet enzym med en anden specificitet.
26. Hydrolysat ifølge krav 2, hvor det mindst ene proteolytiske enzym omfatter en yderligere endopeptidase.
27. Hydrolysat ifølge krav 26, hvor den yderligere endopeptidase er UniProt KB/Swiss-Prot primært accessionsnummer P80057.
28. Anvendelse af mindst ét proteolytisk enzym, som fortrinsvis spalter ved en glutaminsyre- eller asparaginsyrerest, og som spalter én eller flere immunologiske determinanter, der er til stede i mindst ét mælkeprotein, og hvor det mindst ene proteolytiske enzym er en endopeptidase, og hvor endopeptidasen ikke er én med aminosyresekvensen: 5 10 IS 20 25 30 1SVIGSDDRTRVTNTTAYPYRAIVHISSSIG 51 S C T C K K Η P ί ί V A t A C H C ί ϊ H' S S C S P * G T eiATVSPGRKGTSVPYGSVKSTRYfrPSGWRS 91GNTNYDYGAIELSEPIGNTVGYFGYSYTTS 121 SLVGTTVTISG T*P C t K T A G t 0 # « H S O P £ A I isi setyklqyahotyggqsgspvfeqsssrtn ISICSGPCSLAVHTHGVYGGSSYRRGTRITKEV 2HFDNLTNWKNSAQ til fremstilling af et hydrolysat, der omfatter mindst ét mælkeprotein, der er hydrolyseret med mindst ét proteolytisk enzym, hvilket hydrolysat omfatter mindst en beta-lactoglobulin, der er hydrolyseret i området mellem aminosyrerne 55-98, og hvor hydrolysatet er beriget med mindst peptidet AQSAPLRVYVE (SEQ ID NO: 1), til reducering af immunogenicitet i et individ, der er prædisponeret for at få en immunreaktion mod proteinet.
DK07862429.3T 2006-12-20 2007-12-03 Mælkeproteinhydrolysater med reduceret immunogent potentiale DK2124603T3 (da)

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US87596706P 2006-12-20 2006-12-20
PCT/US2007/024723 WO2008088472A2 (en) 2006-12-20 2007-12-03 Milk protein hydrolyzates with reduced immunogenic potential

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EP (1) EP2124603B1 (da)
CN (1) CN101594785B (da)
AU (1) AU2007343749B2 (da)
BR (1) BRPI0721123A2 (da)
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ES (1) ES2529237T3 (da)
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WO (1) WO2008088472A2 (da)

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NZ577510A (en) 2012-06-29
ES2529237T3 (es) 2015-02-18
BRPI0721123A2 (pt) 2014-07-08
CN101594785B (zh) 2014-01-08
CN101594785A (zh) 2009-12-02
AU2007343749B2 (en) 2013-01-10
WO2008088472A3 (en) 2008-10-02
US20100273718A1 (en) 2010-10-28
WO2008088472A2 (en) 2008-07-24
EP2124603B1 (en) 2014-11-19
AU2007343749A1 (en) 2008-07-24
EP2124603A2 (en) 2009-12-02

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