DK2118309T3 - Diagnostic and therapeutic target for autoimmune diseases and uses thereof - Google Patents
Diagnostic and therapeutic target for autoimmune diseases and uses thereof Download PDFInfo
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- DK2118309T3 DK2118309T3 DK07870089T DK07870089T DK2118309T3 DK 2118309 T3 DK2118309 T3 DK 2118309T3 DK 07870089 T DK07870089 T DK 07870089T DK 07870089 T DK07870089 T DK 07870089T DK 2118309 T3 DK2118309 T3 DK 2118309T3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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| GB2486122A (en) * | 2009-09-18 | 2012-06-06 | Univ California | Methods for detecting autodigestion |
| CN102060910B (zh) * | 2010-11-12 | 2012-11-21 | 中国人民解放军第三军医大学 | 锌转运蛋白8的hla-a*0201限制性ctl表位及其应用 |
| KR20250020688A (ko) * | 2011-04-29 | 2025-02-11 | 셀렉타 바이오사이언시즈, 인크. | 항체 반응을 감소시키기 위한 관용원성 합성 나노운반체 |
| US20140271701A1 (en) | 2011-10-26 | 2014-09-18 | Universita' Degli Studi Di Sassari | Use of mycobacterium avium paratuberculosis peptides to diagnose type 1 diabetes |
| CN103177198B (zh) * | 2011-12-26 | 2016-11-23 | 深圳华大基因科技服务有限公司 | 一种蛋白质鉴定方法 |
| IN2014DN09410A (enExample) | 2012-04-13 | 2015-07-17 | Diabetomics Llc | |
| CN102967704B (zh) * | 2012-11-26 | 2014-05-14 | 深圳市伯劳特生物制品有限公司 | 一种用于糖尿病自身抗体6项联检试剂盒 |
| US20160025744A1 (en) * | 2013-03-14 | 2016-01-28 | The Board Of Trustees Of The Leland Stanford Junior University | Plasmonic substrate for multiplex assessment of type 1 diabetes |
| MX2021005697A (es) | 2013-05-03 | 2021-07-07 | Selecta Biosciences Inc | Suministro de inmunosupresores que tienen una vida efectiva especificada, farmacodinamica y antigeno para la induccion de tolerancia inmunitaria. |
| KR102523912B1 (ko) | 2013-06-11 | 2023-04-21 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | SC-β 세포 및 조성물 그리고 그 생성 방법 |
| CN106535926B (zh) * | 2014-06-04 | 2022-02-01 | 戴尔米德医疗公司 | 用于基于抗原的疗法的新型组合物 |
| KR101482908B1 (ko) | 2014-07-25 | 2015-01-15 | 충남대학교산학협력단 | 간질중첩증 진단용 바이오마커 조성물 |
| CN106714826A (zh) | 2014-09-07 | 2017-05-24 | 西莱克塔生物科技公司 | 用于减弱基因表达调节抗病毒转移载体免疫应答的方法和组合物 |
| EP4374863A3 (en) | 2014-12-18 | 2024-09-04 | President and Fellows of Harvard College | Methods for generating stem cell-derived beta cells and uses thereof |
| CN113234661A (zh) | 2014-12-18 | 2021-08-10 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| US10443042B2 (en) | 2014-12-18 | 2019-10-15 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof |
| GB201510056D0 (en) * | 2015-06-10 | 2015-07-22 | King S College London | Multi-peptide composition |
| US10542961B2 (en) | 2015-06-15 | 2020-01-28 | The Research Foundation For The State University Of New York | System and method for infrasonic cardiac monitoring |
| US20170082619A1 (en) | 2015-09-23 | 2017-03-23 | One Lambda, Inc. | Methods of Detecting Alloantibodies Using HLA and Non-HLA Antigens |
| CN106084051B (zh) * | 2016-02-17 | 2018-03-02 | 张梅 | 一种ZnT8特异性单链抗体scFv‑C27及其应用 |
| CN106084043B (zh) * | 2016-02-17 | 2018-03-02 | 张梅 | 一种ZnT8特异性单链抗体scFv‑C22及其应用 |
| WO2017189483A1 (en) | 2016-04-25 | 2017-11-02 | The Johns Hopkins University | Znt8 assays for drug development and pharmaceutical compositions |
| CN106771233A (zh) * | 2016-12-05 | 2017-05-31 | 上海良润生物医药科技有限公司 | ZnT8A自身抗体检测试剂盒 |
| CN110612122A (zh) | 2017-03-11 | 2019-12-24 | 西莱克塔生物科技公司 | 与用抗炎剂和包含免疫抑制剂之合成纳米载体进行的组合治疗相关的方法和组合物 |
| US11892457B2 (en) | 2017-07-12 | 2024-02-06 | The Johns Hopkins University | Proteoliposome-based ZnT8 self-antigen for type 1 diabetes diagnosis |
| MX2020004939A (es) | 2017-11-15 | 2020-11-11 | Semma Therapeutics Inc | Fabricacion de composiciones de celulas islote y metodos de uso de las mismas. |
| CN108414766A (zh) * | 2018-01-29 | 2018-08-17 | 上海良润生物医药科技有限公司 | 用于定量检测糖尿病自身抗体的试剂盒及其应用 |
| AU2019320072A1 (en) | 2018-08-10 | 2021-02-25 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| EP3837286A4 (en) | 2018-08-16 | 2022-08-10 | The Johns Hopkins University | ANTIBODIES TO HUMAN ZNT8 |
| CN109628462B (zh) * | 2018-12-13 | 2021-02-19 | 宁波大学 | 一种水稻根系伸长控制基因OsKSR7及编码的蛋白质 |
| CN109734793B (zh) * | 2019-03-14 | 2022-12-02 | 深圳市药品检验研究院(深圳市医疗器械检测中心) | 一种ZnT8重组蛋白及其制备方法和应用 |
| US12366570B2 (en) | 2019-10-01 | 2025-07-22 | The Johns Hopkins University | Cell-based ZNT8 assay |
| CN111579791A (zh) * | 2020-04-30 | 2020-08-25 | 江苏省人民医院(南京医科大学第一附属医院) | 一种锌转运体8胰岛自身抗体的电化学发光检测试剂盒 |
| CN113999841A (zh) * | 2021-09-16 | 2022-02-01 | 江苏省人民医院(南京医科大学第一附属医院) | 蛋白质支架oval100及其在放射配体法中的应用 |
| CN116589589B (zh) * | 2023-03-24 | 2024-10-22 | 深圳市昭蓝生物科技有限公司 | 糖尿病检测的质控品及其制备方法和用途 |
| CN117031014A (zh) * | 2023-08-14 | 2023-11-10 | 陕西脉元生物科技有限公司 | 抗matr3自身抗体的试剂在制备检测神经系统自身免疫疾病的产品中的应用及试剂盒 |
| CN120714599B (zh) * | 2025-08-28 | 2025-10-31 | 江苏集萃医工交叉技术研究所有限公司 | 一种血清bicc1天然蛋白的高效提取保存方法 |
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| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| CA2043472A1 (en) | 1990-06-04 | 1991-12-05 | Mitsutaka Miyabayashi | Electrode for secondary battery |
| US5820866A (en) * | 1994-03-04 | 1998-10-13 | National Jewish Center For Immunology And Respiratory Medicine | Product and process for T cell regulation |
| US20020082207A1 (en) | 2000-06-07 | 2002-06-27 | Hirst Shannon K. | Compositions and methods for the therapy and diagnosis of pancreatic cancer |
| FR2847263B1 (fr) | 2002-11-18 | 2006-01-13 | Commissariat Energie Atomique | Polynucleotide specifique de la cellule pancreatique beta des ilots de langerhans |
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| ES2533566T3 (es) | 2015-04-13 |
| PL2118309T3 (pl) | 2015-07-31 |
| EP2118309B1 (en) | 2015-01-28 |
| US9023984B2 (en) | 2015-05-05 |
| JP5694668B2 (ja) | 2015-04-01 |
| JP2010514805A (ja) | 2010-05-06 |
| WO2008083331A2 (en) | 2008-07-10 |
| EP2118309A4 (en) | 2010-06-02 |
| CN101646781B (zh) | 2016-06-22 |
| WO2008083331A3 (en) | 2008-11-13 |
| CN101646781A (zh) | 2010-02-10 |
| US20100143374A1 (en) | 2010-06-10 |
| EP2118309A2 (en) | 2009-11-18 |
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