CN101646781B - 自身免疫病的诊断和治疗靶标及其用途 - Google Patents

自身免疫病的诊断和治疗靶标及其用途 Download PDF

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CN101646781B
CN101646781B CN200780051859.3A CN200780051859A CN101646781B CN 101646781 B CN101646781 B CN 101646781B CN 200780051859 A CN200780051859 A CN 200780051859A CN 101646781 B CN101646781 B CN 101646781B
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znt8
human
protein
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cell
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CN101646781A (zh
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约翰·C·赫顿
珍妮特·M·温茨劳
简·詹森
霍华德·戴维森
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University of Colorado Boulder
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
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  • Diabetes (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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CN200780051859.3A 2006-12-29 2007-12-28 自身免疫病的诊断和治疗靶标及其用途 Active CN101646781B (zh)

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US88281506P 2006-12-29 2006-12-29
US60/882,815 2006-12-29
PCT/US2007/089125 WO2008083331A2 (en) 2006-12-29 2007-12-28 Diagnostic and therapeutic target for autoimmune diseases and uses thereof

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CN101646781B true CN101646781B (zh) 2016-06-22

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US (1) US9023984B2 (enExample)
EP (1) EP2118309B1 (enExample)
JP (1) JP5694668B2 (enExample)
CN (1) CN101646781B (enExample)
DK (1) DK2118309T3 (enExample)
ES (1) ES2533566T3 (enExample)
PL (1) PL2118309T3 (enExample)
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CN102060910B (zh) * 2010-11-12 2012-11-21 中国人民解放军第三军医大学 锌转运蛋白8的hla-a＊0201限制性ctl表位及其应用
CN103501812A (zh) * 2011-04-29 2014-01-08 西莱克塔生物科技公司 用于过敏症治疗的致耐受性合成纳米载体
US20140271701A1 (en) 2011-10-26 2014-09-18 Universita' Degli Studi Di Sassari Use of mycobacterium avium paratuberculosis peptides to diagnose type 1 diabetes
CN103177198B (zh) * 2011-12-26 2016-11-23 深圳华大基因科技服务有限公司 一种蛋白质鉴定方法
IN2014DN09410A (enExample) 2012-04-13 2015-07-17 Diabetomics Llc
CN102967704B (zh) * 2012-11-26 2014-05-14 深圳市伯劳特生物制品有限公司 一种用于糖尿病自身抗体6项联检试剂盒
US20160025744A1 (en) * 2013-03-14 2016-01-28 The Board Of Trustees Of The Leland Stanford Junior University Plasmonic substrate for multiplex assessment of type 1 diabetes
CA2910584A1 (en) 2013-05-03 2014-11-06 Selecta Biosciences, Inc. Use of immunosuppressants attached to synthetic nanocarriers to enhance levels of cd4+ regulatory t cells
KR102423106B1 (ko) * 2013-06-11 2022-07-21 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 SC-β 세포 및 조성물 그리고 그 생성 방법
US20170196949A1 (en) * 2014-06-04 2017-07-13 Diamyd Medical Ab Novel combinations for antigen based therapy
KR101482908B1 (ko) 2014-07-25 2015-01-15 충남대학교산학협력단 간질중첩증 진단용 바이오마커 조성물
WO2016037163A1 (en) 2014-09-07 2016-03-10 Selecta Biosciences, Inc. Methods and compositions for attenuating gene therapy anti-viral transfer vector immune responses
WO2016100909A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF
WO2016100930A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Methods for generating stem cell-derived b cells and methods of use thereof
WO2016100898A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof
GB201510056D0 (en) * 2015-06-10 2015-07-22 King S College London Multi-peptide composition
US10542961B2 (en) 2015-06-15 2020-01-28 The Research Foundation For The State University Of New York System and method for infrasonic cardiac monitoring
US20170082619A1 (en) 2015-09-23 2017-03-23 One Lambda, Inc. Methods of Detecting Alloantibodies Using HLA and Non-HLA Antigens
CN106084043B (zh) * 2016-02-17 2018-03-02 张梅 一种ZnT8特异性单链抗体scFv‑C22及其应用
CN106084051B (zh) * 2016-02-17 2018-03-02 张梅 一种ZnT8特异性单链抗体scFv‑C27及其应用
US11016085B2 (en) 2016-04-25 2021-05-25 The Johns Hopkins University ZNT8 assays for drug development and pharmaceutical compositions
CN106771233A (zh) * 2016-12-05 2017-05-31 上海良润生物医药科技有限公司 ZnT8A自身抗体检测试剂盒
EP3592389B1 (en) 2017-03-11 2025-05-07 Cartesian Therapeutics, Inc. Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant
US11892457B2 (en) 2017-07-12 2024-02-06 The Johns Hopkins University Proteoliposome-based ZnT8 self-antigen for type 1 diabetes diagnosis
AU2018370029B2 (en) 2017-11-15 2024-11-07 Vertex Pharmaceuticals Incorporated Islet cell manufacturing compositions and methods of use
CN108414766A (zh) * 2018-01-29 2018-08-17 上海良润生物医药科技有限公司 用于定量检测糖尿病自身抗体的试剂盒及其应用
EP3833365A4 (en) 2018-08-10 2022-05-11 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
EP3837286A4 (en) 2018-08-16 2022-08-10 The Johns Hopkins University ANTIBODIES TO HUMAN ZNT8
CN109628462B (zh) * 2018-12-13 2021-02-19 宁波大学 一种水稻根系伸长控制基因OsKSR7及编码的蛋白质
CN109734793B (zh) * 2019-03-14 2022-12-02 深圳市药品检验研究院（深圳市医疗器械检测中心） 一种ZnT8重组蛋白及其制备方法和应用
US12366570B2 (en) 2019-10-01 2025-07-22 The Johns Hopkins University Cell-based ZNT8 assay
CN111579791A (zh) * 2020-04-30 2020-08-25 江苏省人民医院（南京医科大学第一附属医院） 一种锌转运体8胰岛自身抗体的电化学发光检测试剂盒
CN113999841A (zh) * 2021-09-16 2022-02-01 江苏省人民医院（南京医科大学第一附属医院） 蛋白质支架oval100及其在放射配体法中的应用
CN116589589B (zh) * 2023-03-24 2024-10-22 深圳市昭蓝生物科技有限公司 糖尿病检测的质控品及其制备方法和用途
CN117031014A (zh) * 2023-08-14 2023-11-10 陕西脉元生物科技有限公司 抗matr3自身抗体的试剂在制备检测神经系统自身免疫疾病的产品中的应用及试剂盒
CN120714599B (zh) * 2025-08-28 2025-10-31 江苏集萃医工交叉技术研究所有限公司 一种血清bicc1天然蛋白的高效提取保存方法

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EP2118309A4 (en) 2010-06-02
PL2118309T3 (pl) 2015-07-31
EP2118309B1 (en) 2015-01-28
JP2010514805A (ja) 2010-05-06
US9023984B2 (en) 2015-05-05
WO2008083331A3 (en) 2008-11-13
EP2118309A2 (en) 2009-11-18
US20100143374A1 (en) 2010-06-10
WO2008083331A2 (en) 2008-07-10
ES2533566T3 (es) 2015-04-13
JP5694668B2 (ja) 2015-04-01
CN101646781A (zh) 2010-02-10
DK2118309T3 (en) 2015-03-30

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