DK2089343T3 - Click-kemi til fremstilling af reportermolekyler - Google Patents

Click-kemi til fremstilling af reportermolekyler

Info

Publication number
DK2089343T3
DK2089343T3 DK07819506.2T DK07819506T DK2089343T3 DK 2089343 T3 DK2089343 T3 DK 2089343T3 DK 07819506 T DK07819506 T DK 07819506T DK 2089343 T3 DK2089343 T3 DK 2089343T3
Authority
DK
Denmark
Prior art keywords
reporter molecules
preparation
click chemistry
methods
relates
Prior art date
Application number
DK07819506.2T
Other languages
Danish (da)
English (en)
Inventor
Thomas Carell
Anja Schwoegler
Original Assignee
Baseclick Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baseclick Gmbh filed Critical Baseclick Gmbh
Application granted granted Critical
Publication of DK2089343T3 publication Critical patent/DK2089343T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
DK07819506.2T 2006-10-31 2007-10-31 Click-kemi til fremstilling af reportermolekyler DK2089343T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85557406P 2006-10-31 2006-10-31
PCT/EP2007/009474 WO2008052775A2 (en) 2006-10-31 2007-10-31 Click chemistry for the production of reporter molecules

Publications (1)

Publication Number Publication Date
DK2089343T3 true DK2089343T3 (da) 2011-10-24

Family

ID=39344631

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07819506.2T DK2089343T3 (da) 2006-10-31 2007-10-31 Click-kemi til fremstilling af reportermolekyler

Country Status (14)

Country Link
US (1) US8193335B2 (enExample)
EP (1) EP2089343B1 (enExample)
JP (1) JP5646172B2 (enExample)
CN (1) CN101605743A (enExample)
AT (1) ATE515488T1 (enExample)
AU (1) AU2007315190B2 (enExample)
CA (1) CA2667136A1 (enExample)
DK (1) DK2089343T3 (enExample)
ES (1) ES2369299T3 (enExample)
HR (1) HRP20110554T1 (enExample)
PL (1) PL2089343T3 (enExample)
PT (1) PT2089343E (enExample)
SI (1) SI2089343T1 (enExample)
WO (1) WO2008052775A2 (enExample)

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KR101335218B1 (ko) 2005-05-02 2013-12-12 바스프 에스이 분석물의 감응성 검출을 위한 신규한 표지화 전략
CA2607530C (en) * 2005-05-02 2014-07-08 Basf Aktiengesellschaft New labelling strategies for the sensitive detection of analytes
WO2008052775A2 (en) 2006-10-31 2008-05-08 Baseclick Gmbh Click chemistry for the production of reporter molecules
EP2129772B1 (en) 2007-02-27 2016-07-27 Trustees Of Tufts College Tissue-engineered silk organs
DK2211876T3 (en) 2007-05-29 2015-01-12 Tufts College PROCESS FOR silk fibroin-GELATION USING sonication
US8618297B2 (en) 2008-07-25 2013-12-31 Basf Se Azide substituted naphthylene or rylene imide derivatives and their use as reagents in click-reactions
WO2010039548A2 (en) 2008-09-23 2010-04-08 Alnylam Pharmaceuticals, Inc. Chemical modifications of monomers and oligonucleotides with cycloaddition
EP2358897B1 (en) 2008-11-17 2015-02-25 Headway Technologies, Inc. Methods and compositions in particle-based detection of target molecules using linking molecules
JP5744743B2 (ja) 2008-11-17 2015-07-08 ヘッドウェイ テクノロジーズ, インク.Headway Technologies, Inc. 共有結合形成反応ペアを用いた標的分子の粒子ベースの検出における方法および組成物
JP5569768B2 (ja) * 2008-12-02 2014-08-13 国立大学法人九州大学 ヌクレオシド三リン酸誘導体、核酸プローブ、マルチラベル化核酸プローブおよび標的核酸の検出方法
EP2239053A1 (en) 2009-04-09 2010-10-13 baseclick GmbH Click chemistry on heterogeneous catalysts
US9074302B2 (en) 2009-09-28 2015-07-07 Trustees Of Tufts College Methods of making drawn silk fibers
AU2011317107B2 (en) 2010-10-19 2016-02-25 Trustees Of Tufts College Silk fibroin-based microneedles and methods of making the same
CN102010508B (zh) * 2010-10-19 2012-10-03 北京大学 一种阳离子聚合物及其制备方法和应用
CN103476951B (zh) 2011-02-16 2017-07-28 海德威技术公司 用于可检测的标记的靶标定位锚定的方法和组合物
WO2012145652A1 (en) 2011-04-20 2012-10-26 Trustees Of Tufts College Dynamic silk coatings for implantable devices
US9988680B2 (en) 2011-09-01 2018-06-05 Case Western Reserve University Non-natural nucleosides as theranostic agents
WO2013152619A1 (en) * 2012-04-12 2013-10-17 The Hong Kong University Of Science And Technology Thermosetting poly(siloxane-diphenylbutadiyne) with readily tunable glass transition temperature and high thermal stability
BR112015000236A2 (pt) 2012-07-10 2017-06-27 Baseclick Gmbh moléculas de ácidos nucleicos modificadas por anandamida
CA2891966A1 (en) 2012-12-20 2014-06-26 Sirna Therapeutics, Inc. Post-synthetic orthogonal amidation plus metal catalyzed azide-alkyne cycloaddition click chemistry on sirna
US20160159834A1 (en) * 2013-04-22 2016-06-09 Northwestern University Alkyne phosphoramidites and preparation of spherical nucleic acid constructs
EP3730929A1 (en) * 2013-08-19 2020-10-28 University Of Houston Phosphorescent reporters
CN105764491A (zh) 2013-12-09 2016-07-13 度瑞公司 药物活性剂复合物、聚合物复合物，以及包括其的组合物和方法
HK1244813A1 (zh) * 2014-11-20 2018-08-17 F. Hoffmann-La Roche Ag 氰脲酸酯磷醯胺酯及其衍生物，其用途和合成
JP6667179B2 (ja) * 2015-03-24 2020-03-18 国立大学法人岐阜大学 オリゴヌクレオチド誘導体及びそれを用いたオリゴヌクレオチド構築物並びにそれらの製造方法
WO2017218293A1 (en) 2016-06-16 2017-12-21 Richard Edward Watts Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
WO2018204420A1 (en) 2017-05-02 2018-11-08 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
CN109490523A (zh) * 2018-10-22 2019-03-19 北京纳晶生物科技有限公司 用于标记的纳米材料、核酸探针及核酸与纳米材料偶联的方法
CN112305227A (zh) * 2019-07-31 2021-02-02 深圳市帝迈生物技术有限公司 自交联蛋白、配体组合物、制备方法、试剂盒及系统
CN111018930A (zh) * 2019-12-06 2020-04-17 深圳大学 Tpe-2’-脱氧核苷、荧光凝胶及其制备方法与应用

Family Cites Families (18)

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GB2209754A (en) 1987-09-17 1989-05-24 Thomas Lee Mattson Polyaldehydic polynucleotides in use as probes,their preparation and use
JP2681061B2 (ja) * 1988-06-08 1997-11-19 ロンドン・ダイアグノスティック・インコーポレーテッド 検出可能なシグナルのセンシタイザー誘導発生を利用したアッセイ
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
US5843650A (en) 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
EP2256133B1 (en) * 1997-01-08 2016-12-14 Sigma-Aldrich Co. LLC Bioconjugation of macromolecules
US7427678B2 (en) * 1998-01-08 2008-09-23 Sigma-Aldrich Co. Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
US7205105B2 (en) * 1999-12-08 2007-04-17 Epoch Biosciences, Inc. Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis
DE10013600A1 (de) * 2000-03-18 2002-01-10 Aventis Res & Tech Gmbh & Co Reaktive Monomere für die Oligonucleotid- und Polynucleotidsynthese, modifizierte Oligonucleotide und Polynucleotiden und ein Verfahren zu deren Herstellung
WO2003079014A1 (en) * 2002-03-03 2003-09-25 Activx Biosciences, Inc. Tethered activity-based probes and uses thereof
ATE469135T1 (de) 2002-05-30 2010-06-15 Scripps Research Inst Kupferkatalysierte ligierung von aziden und acetylenen
WO2004055160A2 (en) * 2002-12-13 2004-07-01 The Trustees Of Columbia University In The City Of New York Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
KR100540509B1 (ko) * 2004-01-07 2006-01-11 학교법인 포항공과대학교 수화젤레이터로 사용되는 2'-데옥시우리딘 유도체
US7745118B2 (en) * 2004-04-08 2010-06-29 Roche Nimblegen, Inc. Comparative genomic resequencing
EP1875240A2 (en) 2005-04-27 2008-01-09 Siemens Medical Solutions USA, Inc. The preparation of molecular imaging probes using click chemistry
CA2607530C (en) * 2005-05-02 2014-07-08 Basf Aktiengesellschaft New labelling strategies for the sensitive detection of analytes
EP1937850B1 (en) 2005-10-27 2019-05-29 The President and Fellows of Harvard College Methods and compositions for labeling nucleic acids
WO2008052775A2 (en) 2006-10-31 2008-05-08 Baseclick Gmbh Click chemistry for the production of reporter molecules

Also Published As

Publication number Publication date
WO2008052775A2 (en) 2008-05-08
CN101605743A (zh) 2009-12-16
ATE515488T1 (de) 2011-07-15
ES2369299T3 (es) 2011-11-29
CA2667136A1 (en) 2008-05-08
US8193335B2 (en) 2012-06-05
JP5646172B2 (ja) 2014-12-24
PL2089343T3 (pl) 2011-12-30
HRP20110554T1 (hr) 2011-09-30
SI2089343T1 (sl) 2011-10-28
US20100081137A1 (en) 2010-04-01
AU2007315190B2 (en) 2012-05-31
PT2089343E (pt) 2011-09-06
JP2010508015A (ja) 2010-03-18
EP2089343B1 (en) 2011-07-06
AU2007315190A1 (en) 2008-05-08
WO2008052775A3 (en) 2009-01-15
EP2089343A2 (en) 2009-08-19

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