DK2046369T3 - RECOMBINANT HOST FOR PREPARING L-ASPARAGINASE II - Google Patents
RECOMBINANT HOST FOR PREPARING L-ASPARAGINASE II Download PDFInfo
- Publication number
- DK2046369T3 DK2046369T3 DK07840229.4T DK07840229T DK2046369T3 DK 2046369 T3 DK2046369 T3 DK 2046369T3 DK 07840229 T DK07840229 T DK 07840229T DK 2046369 T3 DK2046369 T3 DK 2046369T3
- Authority
- DK
- Denmark
- Prior art keywords
- asparaginase
- recombinant
- enzyme
- seq
- host cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
- C12N9/82—Asparaginase (3.5.1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81781706P | 2006-06-30 | 2006-06-30 | |
| PCT/US2007/070706 WO2008011234A2 (en) | 2006-06-30 | 2007-06-08 | Recombinant host for producing l-asparaginase ii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2046369T3 true DK2046369T3 (en) | 2015-11-30 |
Family
ID=38957454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07840229.4T DK2046369T3 (en) | 2006-06-30 | 2007-06-08 | RECOMBINANT HOST FOR PREPARING L-ASPARAGINASE II |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7807436B2 (enExample) |
| EP (1) | EP2046369B1 (enExample) |
| JP (1) | JP5308333B2 (enExample) |
| KR (1) | KR101408062B1 (enExample) |
| CN (1) | CN101484181B (enExample) |
| AU (1) | AU2007275535B2 (enExample) |
| CA (1) | CA2652718A1 (enExample) |
| DK (1) | DK2046369T3 (enExample) |
| ES (1) | ES2553329T3 (enExample) |
| HU (1) | HUE025738T2 (enExample) |
| IL (1) | IL195168A (enExample) |
| MX (1) | MX2009000284A (enExample) |
| NZ (1) | NZ572519A (enExample) |
| PL (1) | PL2046369T3 (enExample) |
| PT (1) | PT2046369E (enExample) |
| TW (1) | TWI427148B (enExample) |
| WO (1) | WO2008011234A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR102014000585B1 (pt) | 2014-01-10 | 2021-01-12 | Coppe/Ufrj-Instituto Alberto Luiz Coimbra De Pós-Graduação | l-asparaginase recombinante de zymomonas |
| CN105802948B (zh) | 2014-12-29 | 2020-06-09 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇定点修饰的门冬酰胺酶及其制备方法与应用 |
| US10480014B2 (en) * | 2015-06-15 | 2019-11-19 | Ajou University Industry-Academic Cooperation Foundation | Method for producing natural rubber by using recombinant microorganism |
| EP3463308B2 (en) | 2016-06-01 | 2026-01-07 | Servier IP UK Limited | Formulations of polyalkylene oxide-asparaginase and methods of making and using the same |
| KR101837636B1 (ko) * | 2016-06-14 | 2018-03-12 | 전남대학교산학협력단 | 코리네박테리움 재조합 균주를 이용한 아스파라기나제의 분비생산 방법 |
| CN108795832B (zh) * | 2017-04-26 | 2021-05-14 | 江苏恒瑞医药股份有限公司 | 一种内源l-门冬酰胺酶ii基因敲除的宿主菌、其制备方法及其应用 |
| WO2019083793A1 (en) | 2017-10-27 | 2019-05-02 | Pfenex Inc. | Method for production of recombinant erwinia asparaginase |
| US10662433B2 (en) | 2017-10-27 | 2020-05-26 | Pfenex Inc. | Method for production of recombinant E. coli asparaginase |
| US11364223B2 (en) | 2018-12-13 | 2022-06-21 | Huyabio International, Llc | Sulcardine administration for treatment of acute atrial fibrillation |
| KR20230125179A (ko) | 2020-12-23 | 2023-08-29 | 재즈 파마슈티칼즈 아일랜드 리미티드 | 전하-차폐 융합 단백질의 정제 방법 |
| CN114854729B (zh) * | 2021-02-03 | 2025-09-02 | 重庆派金生物科技有限公司 | 定向化学偶联门冬酰胺酶突变体及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5122614A (en) | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| US5324844A (en) | 1989-04-19 | 1994-06-28 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5615460A (en) * | 1994-06-06 | 1997-04-01 | The Procter & Gamble Company | Female component for refastenable fastening device having regions of differential extensibility |
| US6180095B1 (en) | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| US5965119A (en) | 1997-12-30 | 1999-10-12 | Enzon, Inc. | Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents |
| US6958212B1 (en) | 1999-02-01 | 2005-10-25 | Eidgenossische Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
| US7122189B2 (en) | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7087229B2 (en) | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| CN100502944C (zh) * | 2005-09-16 | 2009-06-24 | 北京双鹭药业股份有限公司 | 一种天门冬酰胺酶注射液、其制备方法及应用 |
-
2007
- 2007-06-08 NZ NZ572519A patent/NZ572519A/en unknown
- 2007-06-08 US US11/759,988 patent/US7807436B2/en active Active
- 2007-06-08 EP EP07840229.4A patent/EP2046369B1/en active Active
- 2007-06-08 CA CA002652718A patent/CA2652718A1/en not_active Abandoned
- 2007-06-08 PT PT78402294T patent/PT2046369E/pt unknown
- 2007-06-08 PL PL07840229T patent/PL2046369T3/pl unknown
- 2007-06-08 HU HUE07840229A patent/HUE025738T2/en unknown
- 2007-06-08 MX MX2009000284A patent/MX2009000284A/es active IP Right Grant
- 2007-06-08 AU AU2007275535A patent/AU2007275535B2/en active Active
- 2007-06-08 JP JP2009518433A patent/JP5308333B2/ja active Active
- 2007-06-08 WO PCT/US2007/070706 patent/WO2008011234A2/en not_active Ceased
- 2007-06-08 DK DK07840229.4T patent/DK2046369T3/en active
- 2007-06-08 ES ES07840229.4T patent/ES2553329T3/es active Active
- 2007-06-08 CN CN2007800248607A patent/CN101484181B/zh active Active
- 2007-06-08 KR KR1020087028792A patent/KR101408062B1/ko active Active
- 2007-06-26 TW TW096123026A patent/TWI427148B/zh not_active IP Right Cessation
-
2008
- 2008-11-09 IL IL195168A patent/IL195168A/en active IP Right Grant
-
2010
- 2010-05-04 US US12/773,320 patent/US20100273236A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TWI427148B (zh) | 2014-02-21 |
| KR20090033175A (ko) | 2009-04-01 |
| AU2007275535A1 (en) | 2008-01-24 |
| EP2046369B1 (en) | 2015-08-12 |
| WO2008011234A3 (en) | 2008-10-16 |
| KR101408062B1 (ko) | 2014-06-20 |
| CN101484181A (zh) | 2009-07-15 |
| MX2009000284A (es) | 2009-01-26 |
| US20100273236A1 (en) | 2010-10-28 |
| AU2007275535B2 (en) | 2012-08-16 |
| CN101484181B (zh) | 2012-12-26 |
| PT2046369E (pt) | 2015-11-26 |
| TW200817518A (en) | 2008-04-16 |
| ES2553329T3 (es) | 2015-12-07 |
| US20080063632A1 (en) | 2008-03-13 |
| EP2046369A2 (en) | 2009-04-15 |
| IL195168A0 (en) | 2011-08-01 |
| HUE025738T2 (en) | 2016-04-28 |
| PL2046369T3 (pl) | 2016-01-29 |
| EP2046369A4 (en) | 2010-04-21 |
| JP2009542219A (ja) | 2009-12-03 |
| NZ572519A (en) | 2011-06-30 |
| JP5308333B2 (ja) | 2013-10-09 |
| US7807436B2 (en) | 2010-10-05 |
| WO2008011234A2 (en) | 2008-01-24 |
| IL195168A (en) | 2014-12-31 |
| CA2652718A1 (en) | 2008-01-24 |
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