DK2035029T3 - Peptidforbindelser til behandling af refraktær status epilepticus. - Google Patents

Peptidforbindelser til behandling af refraktær status epilepticus. Download PDF

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Publication number
DK2035029T3
DK2035029T3 DK07764678.4T DK07764678T DK2035029T3 DK 2035029 T3 DK2035029 T3 DK 2035029T3 DK 07764678 T DK07764678 T DK 07764678T DK 2035029 T3 DK2035029 T3 DK 2035029T3
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seizures
pharmaceutical composition
refractory
use according
status epilepticus
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DK07764678.4T
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Thomas Stöhr
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Ucb Pharma Gmbh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
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  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
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  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (22)

1. Farmaceutisk sammensætning til anvendelse i forebyggelse, lindring eller/og behandling af en refraktær epileptisk lidelse, den farmaceutiske sammensætning omfattende en forbindelse, der har formlen (II)
Formet pS| hvor Ar er phenyl, som er usubstitueret eller substitueret med mindst én halo-gruppe; Ri er alkyl indeholdende 1 til 3 carbonatomer, og R3 er -CH2-Q, hvor Q er alkoxy indeholdende 1 til 3 carbonatomer, eller et farmaceutisk acceptabelt salt deraf.
2. Farmaceutisk sammensætning til anvendelse ifølge krav 1, hvor den refraktære epileptiske lidelse er en refraktær status epilepticus, eller/og en lidelse beslægtet med refraktær status epilepticus.
3. Farmaceutisk sammensætning til anvendelse ifølge krav 1 eller 2, hvor Ri er methyl.
4. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af krav 1 til 3, hvor Ar er phenyl substitueret med mindst én fluorgruppe.
5. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af krav 1 til 3, hvor Ar er usubstitueret phenyl.
6. Farmaceutisk sammensætning til anvendelse ifølge krav 1 eller 2, hvor forbindelsen er (R)-2-acetamido-N-benzyl-3-methoxy-propionamid; (R)-2-acetamido-N-benzyl-3-ethoxy-propionamid; O-methyl-N-acetyl-D-serin-m-fluorbenzylamid; eller O-methyl-N-acetyl-D-serin-p-fluorbenzylamid.
7. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor forbindelsen er i R-konfigurationen.
8. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af krav 1 til 7, hvor forbindelsen ifølge formel (II) er (R)-2-acetamido-N-benzyl-3-methoxypropionamid eller et farmaceutisk acceptabelt salt deraf.
9. Farmaceutisk sammensætning til anvendelse ifølge krav 8, hvor forbindelsen er (R)-2-acetamido-N-benzyl-3-methoxy-propionamid.
10. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor den refraktære epileptiske lidelse er en status epilepticus, et epileptisk anfald, gentagne anfald eller/og et klyngeanfald, som fortsætter i mindst omkring 10 min.
11. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor den refraktære epileptiske lidelse er mindst delvist refraktær eller væsentligt refraktær mod lægemidler, som anvendes i behandling af status epilepticus eller/og epilepsi, i særdeleshed mod mindst ét lægemiddel valgt blandt benzodiazepiner, barbiturater, og antiepileptiske lægemidler forskellige fra forbindelserne ifølge krav 1, fortrinsvis valgt blandt diazepam, lorazepam, midazolam, phenobarbital, carbamazepin, phenytoin, fosphe-nytoin, oxcarbazepin, lamotrigin, gabapentin, pregabalin, valproinsyre, pentobarbital, thiopental, propofol og farmaceutisk acceptable salte deraf.
12. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor den refraktære epileptiske lidelse omfatter fokale anfald eller/og generaliserede anfald og/eller, hvor den refraktære epileptiske lidelse omfatter konvulsive anfald, såsom tonisk-kloniske, toniske, kloniske, eller myokloniske anfald, eller/og non-konvulsive anfald, såsom absencer eller atoniske anfald og/eller, hvor den refraktære epileptiske lidelse eller en beslægtet lidelse omfatter akut gentagne anfald eller/og klyngeanfald.
13. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor den refraktære epileptiske lidelse eller en beslægtet lidelse omfatter akut gentagne anfald.
14. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor lidelsen beslægtet med refraktær status epilepticus er epileptogenese.
15. Farmaceutisk sammensætning omfattende (a) mindst én forbindelse ifølge formel (II) som defineret i et hvilket som helst af krav 1 og 3 til 9, fortrinsvis lacosamid, og (b) mindst én benzodiazepin, fortrinsvis diazepam, lorazepam eller/og midazolam.
16. Farmaceutisk sammensætning ifølge krav 15 til anvendelse i forebyggelse, lindring eller/og behandling af en epileptisk lidelse.
17. Farmaceutisk sammensætning til anvendelse i forebyggelsen, lindringen eller/og behandlingen af epileptogenese, sammensætningen omfattende mindst én forbindelse, der har formlen (II)
Ferme! (it) hvor Ar er phenyl, som er usubstitueret eller substitueret med mindst én halogruppe; Ri er alkyl som indeholder 1 til 3 carbonatomer, og R3 er -CFI2-Q, hvor Q er alkoxy, som indeholder 1 til 3 carbonatomer, eller et farmaceutisk acceptabelt salt deraf.
18. Farmaceutisk sammensætning til anvendelse ifølge krav 17, hvor epileptogenese er beslægtet med status epilepticus, såsom refraktær status epilepticus.
19. Farmaceutisk sammensætning til anvendelse ifølge krav 17 eller 18, hvor epilep-togenesen indbefatter udvikling af epilepsi, såsom kronisk epilepsi, eller en epileptisk lidelse valgt blandt status epilepticus, et epileptisk anfald, gentagne anfald eller/og et klyngeanfald, som fortsætter i mindst omkring 10 min.
20. Farmaceutisk sammensætning til anvendelse ifølge krav 19, hvor den epileptiske lidelse omfatter fokale anfald eller/og generaliserede anfald og/eller, hvor den epileptiske lidelse omfatter konvulsive anfald, såsom tonisk-kloniske, toniske, kloniske, eller myokloni-ske anfald eller/og non-konvulsive anfald såsom absencer eller atoniske anfald eller/og, hvor den epileptiske lidelse eller en beslægtet lidelse omfatter akut gentagne anfald eller/og klyngeanfald.
21. Farmaceutisk sammensætning til anvendelse ifølge krav 19 eller 20, hvor den epileptiske lidelse eller en beslægtet lidelse omfatter akut gentagne anfald
22. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af kravene 17 til 21, hvor forbindelsen ifølge formel (II) er lacosamid.
DK07764678.4T 2006-06-15 2007-06-15 Peptidforbindelser til behandling af refraktær status epilepticus. DK2035029T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81396706P 2006-06-15 2006-06-15
EP06013655A EP1873527A1 (en) 2006-06-30 2006-06-30 Method for identifying CRMP modulators
PCT/EP2007/005306 WO2007144196A2 (en) 2006-06-15 2007-06-15 Peptide compounds for treating refractory status epilepticus

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US (3) US20100273714A1 (da)
EP (2) EP1873527A1 (da)
JP (1) JP5795145B2 (da)
KR (2) KR101517133B1 (da)
CN (3) CN103751157A (da)
AR (1) AR061475A1 (da)
AU (1) AU2007260208B2 (da)
BR (1) BRPI0713702A2 (da)
CA (1) CA2651684C (da)
CY (1) CY1118523T1 (da)
DK (1) DK2035029T3 (da)
EA (1) EA018607B1 (da)
ES (1) ES2613931T3 (da)
HU (1) HUE033180T2 (da)
LT (1) LT2035029T (da)
MX (1) MX2008015951A (da)
PL (1) PL2035029T3 (da)
PT (1) PT2035029T (da)
SI (1) SI2035029T1 (da)
TW (1) TWI422384B (da)
WO (1) WO2007144196A2 (da)

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EP2035029A2 (en) 2009-03-18
CA2651684C (en) 2017-09-12
MX2008015951A (es) 2009-01-12
PT2035029T (pt) 2017-02-03
WO2007144196A3 (en) 2008-08-21
US20100273714A1 (en) 2010-10-28
CN103751157A (zh) 2014-04-30
SI2035029T1 (sl) 2017-03-31
CA2651684A1 (en) 2007-12-21
PL2035029T3 (pl) 2017-05-31
LT2035029T (lt) 2017-02-10
ES2613931T3 (es) 2017-05-29
CN101489591B (zh) 2013-09-11
CY1118523T1 (el) 2017-07-12
KR20140042926A (ko) 2014-04-07
AU2007260208B2 (en) 2012-04-12
JP2009539910A (ja) 2009-11-19
EA018607B1 (ru) 2013-09-30
TWI422384B (zh) 2014-01-11
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CN101636180B (zh) 2012-11-28
EP1873527A1 (en) 2008-01-02
AR061475A1 (es) 2008-08-27
EP2035029B1 (en) 2016-11-30
EA200900021A1 (ru) 2009-06-30
HUE033180T2 (en) 2017-11-28
TW200815024A (en) 2008-04-01
KR101517133B1 (ko) 2015-05-04
KR20090030307A (ko) 2009-03-24
CN101636180A (zh) 2010-01-27
US20140128378A1 (en) 2014-05-08
BRPI0713702A2 (pt) 2012-10-30
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AU2007260208A1 (en) 2007-12-21
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