DK2017596T3 - Fluidstyrings- og behandlingsfremgangsmåde - Google Patents

Fluidstyrings- og behandlingsfremgangsmåde Download PDF

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Publication number
DK2017596T3
DK2017596T3 DK08015803.3T DK08015803T DK2017596T3 DK 2017596 T3 DK2017596 T3 DK 2017596T3 DK 08015803 T DK08015803 T DK 08015803T DK 2017596 T3 DK2017596 T3 DK 2017596T3
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DK
Denmark
Prior art keywords
fluid
chamber
fluid displacement
displacement chamber
chambers
Prior art date
Application number
DK08015803.3T
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English (en)
Inventor
Douglas B Dority
Original Assignee
Cepheid
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Publication of DK2017596T3 publication Critical patent/DK2017596T3/da

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N35/1097Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16Reagents, handling or storing thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0681Filter
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0622Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0644Valves, specific forms thereof with moving parts rotary valves

Claims (11)

1. Fremgangsmåde til styring af en fluidstrøm mellem et ventillegeme (20) og en flerhed af kamre, hvor ventillegemet omfatter en flerhed af udvendige åbninger (42, 46, 110, 112), et fluidforskydningskammer (50, 108) og et fluid-prøvebehandlingsområde (30, 110), hvor fluidforskydningskammeret er flui-disk kontinuerligt koblet med fluidprøvebehandlingsområdet (30, 110), der er fluidisk koblet med mindst to af de udvendige åbninger (42, 46, 110, 112), kendetegnet ved, at flerheden af kamre er i et hus (12, 102), og fluidforskydningskammeret (50, 108) og fluidprøvebehandlingsområdet (30, 110) er to separate områder, der er indeholdt i ventillegemet, og fremgangsmåden omfatter: (a) at indstille ventillegemet (20) i forhold til huset (12, 102) til anbringelse af en udvendig åbning i selektiv fluidforbindelse med et første kammer af flerheden af kamre i huset; (b) at reducere trykket i fluidforskydningskammeret (50, 108) for at indsuge fluid fra det første kammer til fluidforskydningskammeret (50, 108); (c) at indstille ventillegemet (20) i forhold til huset (12, 102) til anbringelse af en udvendig åbning og fluidforskydningskammeret (50, 108) i selektiv fluidforbindelse med et andet kammer af flerheden af kamre i huset (12,102); og (d) at tryksætte fluidforskydningskammeret (50, 108) for at udstøde fluid fra fluidforskydningskammeret (50, 108) til det anden kammer.
2. Fremgangsmåde ifølge krav 1, hvor det første kammer vælges fra gruppen bestående af et prøvekammer, et vaskekammer, et lysiskammer, et master-mixkammer og en reaktionsbeholder, og hvor det andet kammer er et spildkammer.
3. Fremgangsmåde ifølge krav 1 eller krav 2, hvor ventillegemet endvidere omfatter et fluidforskydningselement (54, 106, 210), der er anbragt i fluidforskydningskammeret (50, 108) til indstilling af fluidforskydningskammerets volumen, hvor trinnet med at reducere trykket i fluidforskydningskammeret indebærer at bevæge fluidforskydningselementet (54, 106, 210) for at forøge fluidforskydningskammerets (50, 108) volumen, og trinnet med at tryksætte fluidforskydningskammeret indebærer at bevæge fluidforskydningselementet (54, 106, 210) for at reducere fluidforskydningskammerets (50, 108) volu- men.
4. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor trinnet med at indsuge fluid i fluidforskydningskammeret (50, 108) går uden om fluidprøvebehandlingsområdet (30, 110).
5. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor fluidprøvebehandlingsområdet (30, 110) er placeret mellem fluidforskydningskammeret (50, 108) og mindst en af de udvendige åbninger (42, 46, 110, 112), hvor trinnet med at udstøde fluid fra fluidforskydningskammeret driver fluiden gennem fluidprøvebehandlingsområdet, før det strømmer ind i det andet kammer.
6. Fremgangsmåde ifølge krav 5, hvor fluidprøvebehandlingsområdet (30, 110) endvidere omfatter et fangelement (27) til opfangning af bestanddele af fluidprøven.
7. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, omfattende et yderligere trin, der følger efter trin (d), hvor ventillegemet (20) indstilles i forhold til huset (12, 102) for fluidisk at isolere fluidforskydningskammeret (50, 108) og fluidprøvebehandlingsområdet (30, 110) fra flerheden af kamre i huset.
8. Fremgangsmåde ifølge krav 7, endvidere omfattende trinnet med at tryksætte fluidforskydningskammeret (50, 108) efter indstilling af ventillegemet til fluidisk at isolere fluidforskydningskammeret og fluidprøvebehandlingsområdet fra flerheden af kamre.
9. Fremgangsmåde ifølge krav 8, hvor systemet endvidere omfatter et sonisk element (76), der er funktionsforbundet med en udvendig afdækning (28) af fluidprøvebehandlingsområdet (30, 110), hvor fremgangsmåden endvidere omfatter trinnet med at overføre sonisk energi til fluidprøvebehandlingsområdet (30, 110) for at fremme lysering af prøvebestanddelene.
10. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor systemet endvidere omfatter en overgangskanal (56), og flerheden af kamre i huset omfatter et mastermixkammer og en reaktionsbeholder, hvor fremgangsmåden endvidere omfatter trinnet med (i) at indstille ventillegemet (20) til at anbringe overgangskanalen (56) i fluidforbindelse med mastermixkam-meret og reaktionsbeholderen og (ii) at reducere trykket i fluidforskydningskammeret (50, 108) for at indsuge fluid fra mastermixkammeret gennem overgangskanalen (56) til reaktionsbeholderen.
11. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor ventillegemet er et rotationsventillegeme, og fremgangsmåden omfatter trinnet med at rotere ventillegemet omkring en akse og i forhold til flerheden af kamre, således at de udvendige åbninger (42, 46, 110, 112) kan anbringes i selektiv fluidforbindelse med flerheden af kamre.
DK08015803.3T 2000-08-25 2001-07-26 Fluidstyrings- og behandlingsfremgangsmåde DK2017596T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/648,570 US6374684B1 (en) 2000-08-25 2000-08-25 Fluid control and processing system
EP01957312A EP1325298B1 (en) 2000-08-25 2001-07-26 Fluid control and processing system

Publications (1)

Publication Number Publication Date
DK2017596T3 true DK2017596T3 (da) 2017-01-16

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DK01957312T DK1325298T3 (da) 2000-08-25 2001-07-26 Væskestyring- og væskebearbejdnings-system

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US (1) US6374684B1 (da)
EP (3) EP1325298B1 (da)
JP (9) JP4663959B2 (da)
AT (1) ATE408129T1 (da)
AU (2) AU7907001A (da)
CA (5) CA2419862C (da)
DE (1) DE60135766D1 (da)
DK (2) DK2017596T3 (da)
ES (3) ES2313972T3 (da)
WO (1) WO2002018902A1 (da)

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