DK1988903T3 - Fremgangsmåde til at opretholde tand- og mundsundhed i dyr under anvendelse af morpholinderivater - Google Patents

Fremgangsmåde til at opretholde tand- og mundsundhed i dyr under anvendelse af morpholinderivater Download PDF

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Publication number
DK1988903T3
DK1988903T3 DK07712798.3T DK07712798T DK1988903T3 DK 1988903 T3 DK1988903 T3 DK 1988903T3 DK 07712798 T DK07712798 T DK 07712798T DK 1988903 T3 DK1988903 T3 DK 1988903T3
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DK
Denmark
Prior art keywords
composition
animal
compound
teeth
acid
Prior art date
Application number
DK07712798.3T
Other languages
English (en)
Inventor
Bruyn Hugo De
Rolf Valter Attoström
Original Assignee
Maelor Laboratories Ltd
Merial Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maelor Laboratories Ltd, Merial Inc filed Critical Maelor Laboratories Ltd
Application granted granted Critical
Publication of DK1988903T3 publication Critical patent/DK1988903T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Birds (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Claims (8)

1. Sammensætning omfattende en morpholinoforbindelse med formlen (I), til anvendelse i behandlingen af gingivitis og til ledsagende behandling af halitose i et husdyr I
hvor Ri er en lige eller forgrenet alkylgruppe indeholdende 8 til 16 carbonatomer ved 2- eller 3-positionen af morpholino-ringen, og R2 er en lige eller forgrenet alkylgruppe indeholdende 2 til 10 carbonatomer, substitueret med en hydroxygruppe undtagen i alfa-position, eller et farmaceutisk acceptabelt salt deraf, sammensætningen er coatet på eller infunderet i et dyretyggemiddel.
2. Sammensætning til anvendelse ifølge krav 1, hvor summen af carbonatomerne i grupperne Ri og R2 af morpholinoforbindelsen er mindst 10, fortrinsvis mellem 10 og 20.
3. Sammensætning til anvendelse ifølge krav 1 eller 2, hvor R2 afsluttes med hydroxygruppen.
4. Sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor morpholinoforbindelsen er 3-(4-propyl-heptyl)-4-(2-hydroxyethyl)-morpholin.
5. Sammensætning til anvendelse ifølge krav 1, hvor dyret er en hund.
6. Sammensætning til anvendelse ifølge krav 1, hvor dyret er en kat.
7. Sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, yderligere omfattende en farmaceutisk acceptabel excipiens.
8. Sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, yderligere omfattende et antiinflammatorisk middel.
DK07712798.3T 2006-02-28 2007-02-27 Fremgangsmåde til at opretholde tand- og mundsundhed i dyr under anvendelse af morpholinderivater DK1988903T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0604018.2A GB0604018D0 (en) 2006-02-28 2006-02-28 Method
PCT/GB2007/000680 WO2007099302A2 (en) 2006-02-28 2007-02-27 Methods of maintaining oral health in animals using morpholine derivatives

Publications (1)

Publication Number Publication Date
DK1988903T3 true DK1988903T3 (da) 2017-10-09

Family

ID=36178958

Family Applications (2)

Application Number Title Priority Date Filing Date
DK16186662.9T DK3156057T3 (da) 2006-02-28 2007-02-27 Delmopinol-belagt dyretyggeartikel til anvendelse til forebyggelsen eller behandlingen af halitosis
DK07712798.3T DK1988903T3 (da) 2006-02-28 2007-02-27 Fremgangsmåde til at opretholde tand- og mundsundhed i dyr under anvendelse af morpholinderivater

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK16186662.9T DK3156057T3 (da) 2006-02-28 2007-02-27 Delmopinol-belagt dyretyggeartikel til anvendelse til forebyggelsen eller behandlingen af halitosis

Country Status (12)

Country Link
US (5) US20110171143A1 (da)
EP (2) EP3156057B1 (da)
CY (1) CY1119460T1 (da)
DK (2) DK3156057T3 (da)
ES (2) ES2648218T3 (da)
GB (1) GB0604018D0 (da)
HU (2) HUE037203T2 (da)
LT (1) LT1988903T (da)
PL (2) PL1988903T3 (da)
PT (2) PT1988903T (da)
SI (1) SI1988903T1 (da)
WO (1) WO2007099302A2 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0604018D0 (en) * 2006-02-28 2006-04-05 Sinclair Pharmaceuticals Ltd Method
WO2014175757A1 (ru) * 2013-04-22 2014-10-30 Общество с ограниченной ответственностью "Нанобиотех" Антисептический ветеринарный препарат и способы его использования
IT201600130642A1 (it) 2016-12-23 2018-06-23 Lundbeck Pharmaceuticals Italy S P A Processo per la produzione di 2(3 alchilmorfolino)-etan-1-olo
IT201600130729A1 (it) 2016-12-23 2018-06-23 Lundbeck Pharmaceuticals Italy S P A Processo per la produzione degli intermedi del delmopinolo
IT201600130538A1 (it) 2016-12-23 2018-06-23 Lundbeck Pharmaceuticals Italy S P A Processo per la produzione del delmopinolo
IT201700076821A1 (it) * 2017-08-24 2019-02-24 Lundbeck Pharmaceuticals Italy S P A Nuovo sale del delmopinolo
JP7424685B2 (ja) 2020-01-31 2024-01-30 ユー ファースト サービシズ インコーポレイテッド デルモピノール及びその塩の製造方法
WO2023183879A1 (en) * 2022-03-23 2023-09-28 You First Services, Inc. Methods for irrigation using delmopinol and delmopinol salts

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US4329333A (en) 1980-11-24 1982-05-11 Arthur Barr Method for the oral treatment of dogs and other animals
US4894221A (en) * 1981-03-19 1990-01-16 Ab Ferrosan Method of treating plaque using morpholine compounds
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Also Published As

Publication number Publication date
PT1988903T (pt) 2017-11-30
HUE065668T2 (hu) 2024-06-28
WO2007099302A2 (en) 2007-09-07
LT1988903T (lt) 2018-01-25
PL3156057T3 (pl) 2024-03-18
WO2007099302A3 (en) 2008-06-19
EP1988903A2 (en) 2008-11-12
PL1988903T3 (pl) 2018-02-28
SI1988903T1 (sl) 2017-12-29
WO2007099302A8 (en) 2008-09-04
ES2961931T3 (es) 2024-03-14
GB0604018D0 (en) 2006-04-05
EP3156057B1 (en) 2023-10-04
US10206928B2 (en) 2019-02-19
US11660300B2 (en) 2023-05-30
US20150231048A1 (en) 2015-08-20
US20110268671A1 (en) 2011-11-03
EP1988903B1 (en) 2017-08-23
ES2648218T3 (es) 2017-12-29
PT3156057T (pt) 2023-12-07
US20180064719A1 (en) 2018-03-08
EP3156057A2 (en) 2017-04-19
US20190175607A1 (en) 2019-06-13
DK3156057T3 (da) 2024-01-29
EP3156057A3 (en) 2017-07-26
HUE037203T2 (hu) 2018-08-28
CY1119460T1 (el) 2018-03-07
US20110171143A1 (en) 2011-07-14

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