DK1951866T3 - Delta-9-elongaser og anvendelse heraf til fremstilling af flerumættede fedtsyrer - Google Patents

Delta-9-elongaser og anvendelse heraf til fremstilling af flerumættede fedtsyrer

Info

Publication number
DK1951866T3
DK1951866T3 DK06837764.7T DK06837764T DK1951866T3 DK 1951866 T3 DK1951866 T3 DK 1951866T3 DK 06837764 T DK06837764 T DK 06837764T DK 1951866 T3 DK1951866 T3 DK 1951866T3
Authority
DK
Denmark
Prior art keywords
elongases
delta
manufacture
saturated fat
fat acids
Prior art date
Application number
DK06837764.7T
Other languages
Danish (da)
English (en)
Inventor
Howard Glenn Damude
Brian Mcgonigle
Zhixiong Xue
Quinn Qun Zhu
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Application granted granted Critical
Publication of DK1951866T3 publication Critical patent/DK1951866T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00Production of fats or fatty oils from raw materials
    • C11B1/02Pretreatment
    • C11B1/025Pretreatment by enzymes or microorganisms, living or dead
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409Fatty acids
    • C12P7/6427Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436Fatty acid esters
    • C12P7/6445Glycerides
    • C12P7/6458Glycerides by transesterification, e.g. interesterification, ester interchange, alcoholysis or acidolysis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436Fatty acid esters
    • C12P7/6445Glycerides
    • C12P7/6463Glycerides obtained from glyceride producing microorganisms, e.g. single cell oil
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436Fatty acid esters
    • C12P7/6445Glycerides
    • C12P7/6472Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Feed For Specific Animals (AREA)
  • Fodder In General (AREA)
  • Enzymes And Modification Thereof (AREA)
DK06837764.7T 2005-11-23 2006-11-16 Delta-9-elongaser og anvendelse heraf til fremstilling af flerumættede fedtsyrer DK1951866T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73998905P 2005-11-23 2005-11-23
PCT/US2006/044480 WO2007061742A1 (en) 2005-11-23 2006-11-16 Delta-9 elongases and their use in making polyunsaturated fatty acids

Publications (1)

Publication Number Publication Date
DK1951866T3 true DK1951866T3 (da) 2014-10-27

Family

ID=37836626

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06837764.7T DK1951866T3 (da) 2005-11-23 2006-11-16 Delta-9-elongaser og anvendelse heraf til fremstilling af flerumættede fedtsyrer

Country Status (11)

Country Link
US (6) US20070118929A1 (cg-RX-API-DMAC7.html)
EP (2) EP1957641A2 (cg-RX-API-DMAC7.html)
JP (1) JP5123861B2 (cg-RX-API-DMAC7.html)
KR (1) KR20080071190A (cg-RX-API-DMAC7.html)
CN (1) CN101365788B (cg-RX-API-DMAC7.html)
AU (2) AU2006316610B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0620552A2 (cg-RX-API-DMAC7.html)
CA (2) CA2625855C (cg-RX-API-DMAC7.html)
DK (1) DK1951866T3 (cg-RX-API-DMAC7.html)
NO (1) NO20082466L (cg-RX-API-DMAC7.html)
WO (2) WO2007061742A1 (cg-RX-API-DMAC7.html)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005103253A1 (en) 2004-04-22 2005-11-03 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
US7807849B2 (en) 2004-04-22 2010-10-05 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
GB0603160D0 (en) 2006-02-16 2006-03-29 Rothamsted Res Ltd Nucleic acid
RU2009111266A (ru) 2006-08-29 2010-10-10 Коммонвелт Сайентифик энд Индастриал Рисерч Организейшн (AU) Синтез жирных кислот
UA102059C2 (uk) * 2006-10-23 2013-06-10 Е.І. Дю Пон Де Немур Енд Компані Дельта-8 десатураза та її застосування для одержання поліненасичених жирних кислот
US8916361B2 (en) 2006-11-17 2014-12-23 Abbott Laboratories Elongase gene and uses thereof
US20080125487A1 (en) * 2006-11-17 2008-05-29 Tapas Das Elongase gene and uses thereof
US7709239B2 (en) * 2006-12-07 2010-05-04 E.I. Du Pont De Nemours And Company Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids
UA102063C2 (uk) 2007-02-12 2013-06-10 Е. І. Дю Пон Де Немур Енд Компані Трансгенна соєва рослина, що продукує арахідонову кислоту
UA103595C2 (uk) * 2007-04-03 2013-11-11 Е. І. Дю Пон Де Немур Енд Компані Мультизими і їх застосування в отриманні поліненасичених жирних кислот
US7790156B2 (en) 2007-04-10 2010-09-07 E. I. Du Pont De Nemours And Company Δ-8 desaturases and their use in making polyunsaturated fatty acids
US7794701B2 (en) * 2007-04-16 2010-09-14 E.I. Du Pont De Nemours And Company Δ-9 elongases and their use in making polyunsaturated fatty acids
CA2695112A1 (en) 2007-07-31 2009-02-05 Basf Plant Science Gmbh Elongases and processes for the production of polyunsaturated fatty acids in transgenic organisms
CN101883843B (zh) * 2007-10-03 2016-03-02 纳幕尔杜邦公司 破坏过氧化物酶体生物合成因子蛋白(pex)以改变含油真核生物中多不饱和脂肪酸和总脂质含量
CN101970638B (zh) 2007-10-03 2015-02-11 纳幕尔杜邦公司 用于高水平生产二十碳五烯酸的优化解脂耶氏酵母菌株
US8168858B2 (en) 2008-06-20 2012-05-01 E. I. Du Pont De Nemours And Company Delta-9 fatty acid elongase genes and their use in making polyunsaturated fatty acids
AU2009317860B2 (en) 2008-11-18 2014-03-27 Commonwealth Scientific And Industrial Research Organisation Enzymes and methods for producing omega-3 fatty acids
US9175318B2 (en) 2008-12-18 2015-11-03 E. I. Dupont De Nemours And Company Reducing byproduction of malonates by yeast in a fermentation process
CA2755027C (en) 2009-04-01 2018-09-18 E. I. Du Pont De Nemours And Company Use of a seed specific promoter to drive odp1 expression in cruciferous oilseed plants to increase oil content while maintaining normal germination
WO2010118362A1 (en) * 2009-04-09 2010-10-14 The Regents Of The University Of Colorado, A Body Corporate Methods and compositions for inducing physiological hypertrophy
CN102595917A (zh) 2009-06-16 2012-07-18 纳幕尔杜邦公司 来自改善的优化的解脂耶氏酵母菌株的高二十碳五烯酸油
EP2475679B1 (en) 2009-06-16 2016-02-10 E. I. du Pont de Nemours and Company Improved optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production
CA2763424C (en) 2009-06-16 2018-06-12 E.I. Du Pont De Nemours And Company Improvement of long chain omega-3 and omega-6 polyunsaturated fatty acid biosynthesis by expression of acyl-coa lysophospholipid acyltransferases
CA2764073A1 (en) 2009-06-30 2011-01-20 E. I. Du Pont De Nemours And Company Plant seeds with altered storage compound levels, related constructs and methods involving genes encoding cytosolic pyrophosphatase
US8188335B2 (en) * 2009-07-17 2012-05-29 Abbott Laboratories Δ9-elongase for production of polyunsaturated fatty acid-enriched oils
AR078829A1 (es) 2009-10-30 2011-12-07 Du Pont Plantas y semillas con niveles alterados de compuesto de almacenamiento, construcciones relacionadas y metodos relacionados con genes que codifican proteinas similares a las aldolasas bacterianas de la clase ii del acido 2,4- dihidroxi-hept-2-eno-1,7-dioico
IN2012DN05162A (cg-RX-API-DMAC7.html) 2009-12-24 2015-10-23 Du Pont
US20110178105A1 (en) 2010-01-15 2011-07-21 E.I. Du Pont De Nemours And Company Clinical benefits of eicosapentaenoic acid in humans
CA2790836A1 (en) 2010-03-03 2011-09-09 E.I. Du Pont De Nemours And Company Plant seeds with altered storage compound levels, related constructs and methods involving genes encoding oxidoreductase motif polypeptides
CA2795460A1 (en) 2010-04-22 2011-10-27 E. I. Du Pont De Nemours And Company Method for obtaining polyunsaturated fatty acid-containing compositions from microbial biomass
AU2011271497A1 (en) 2010-07-01 2013-01-10 E. I. Du Pont De Nemours And Company Plant seeds with altered storage compound levels, related constructs and methods involving genes encoding PAE and PAE-like polypeptides
US20120040076A1 (en) 2010-08-11 2012-02-16 E. I. Du Pont De Nemours And Company Aquaculture feed compositions
CA2805891A1 (en) 2010-08-11 2012-02-16 Scott E. Nichols A sustainable aquaculture feeding strategy
CA2805882A1 (en) 2010-08-11 2012-02-16 E. I. Dupont De Nemours And Company Improved aquaculture meat products
US8658413B2 (en) 2010-08-26 2014-02-25 E I Du Pont De Nemours And Company Mutant HPGG motif and HDASH motif delta-5 desaturases and their use in making polyunsaturated fatty acids
AU2011293180B2 (en) 2010-08-26 2017-03-02 E. I. Du Pont De Nemours And Company Recombinant microbial host cells for high eicosapentaenoic acid production
KR20140008295A (ko) * 2010-08-26 2014-01-21 이 아이 듀폰 디 네모아 앤드 캄파니 돌연변이 델타-9 연장효소 및 다중불포화 지방산의 제조에서의 그들의 용도
US8735137B2 (en) 2010-12-30 2014-05-27 E I Du Pont De Nemours And Company Use of Saccharomyces cerevisiae SUC2 gene in Yarrowia lipolytica for sucrose utilization
US20130040340A1 (en) 2011-02-07 2013-02-14 E. I. Du Pont De Nemours And Company Production of alcohol esters in situ using alcohols and fatty acids produced by microorganisms
CA3026436A1 (en) 2011-02-11 2012-08-16 E. I. Du Pont De Nemours And Company Method for obtaining a lipid-containing composition from microbial biomass
WO2012135773A1 (en) 2011-03-31 2012-10-04 E. I. Du Pont De Nemours And Company Yarrowia diacylglycerol acyltransferase promoter regions for gene expression in yeast
EP2694665A1 (en) 2011-04-01 2014-02-12 E. I. Du Pont de Nemours and Company Yarrowia esterase/lipase promoter regions for gene expression in yeast
US20120247066A1 (en) 2011-04-01 2012-10-04 Ice House America, Llc Ice bagging apparatus and methods
WO2012138613A1 (en) 2011-04-05 2012-10-11 E. I. Du Pont De Nemours And Company Yarrowia n-alkane-hydroxylating cytochrome p450 promoter regions for gene expression in yeast
US8609369B2 (en) 2011-04-07 2013-12-17 E I Du Pont De Nemours And Company Yarrowia peroxisomal 2,4-dienoyl-CoA reductase promoter regions for gene expression in yeast
BR112014015564B8 (pt) 2011-12-22 2022-11-08 Du Pont Construtos de dna recombinante e métodos de aumento do teor de óleo de sementes de soja
WO2013112523A2 (en) 2012-01-23 2013-08-01 E. I. Du Pont De Nemours And Company Down-regulation of gene expression using artificial micrornas for silencing fatty acid biosynthestic genes
US8816111B2 (en) 2012-06-15 2014-08-26 Commonwealth Scientific And Industrial Research Organisation Lipid comprising polyunsaturated fatty acids
EP2935591B1 (en) 2012-12-21 2017-07-05 E. I. du Pont de Nemours and Company Down-regulation of a polynucleotide encoding a sou2 sorbitol utilization protein to modify lipid production in microbial cells
EP3030647A4 (en) 2013-06-12 2017-05-03 Solarvest Bioenergy Inc. Methods of producing algal cell cultures and biomass, lipid compounds and compositions, and related products
US20160272997A1 (en) 2013-10-25 2016-09-22 Pioneer Hi-Bred International, Inc. Stem canker tolerant soybeans and methods of use
WO2015196250A1 (en) 2014-06-27 2015-12-30 Commonwealth Scientific And Industrial Research Organisation Lipid comprising docosapentaenoic acid
AU2014366839B2 (en) 2013-12-18 2021-07-01 Commonwealth Scientific And Industrial Research Organisation Lipid comprising long chain polyunsaturated fatty acids
FR3028527A1 (fr) * 2014-11-13 2016-05-20 Pivert Identification de facteurs de transcription de yarrowia lipolytica
ES2608968B1 (es) * 2015-09-08 2018-03-01 Neol Biosolutions, S.A. Producción de aceites microbianos con alto contenido en ácidos grasos de cadena muy larga
CN106874709B (zh) * 2015-12-12 2019-03-01 北京大学 测序结果中序列数据错误的检测和校正方法
CA3005671A1 (en) 2015-11-19 2017-05-26 Peking University Methods for obtaining and correcting biological sequence information
WO2017136204A1 (en) 2016-02-05 2017-08-10 Pioneer Hi-Bred International, Inc. Genetic loci associated with brown stem rot resistance in soybean and methods of use
FR3053052B1 (fr) * 2016-06-28 2021-02-12 Fermentalg Microalgue modifiee pour une production enrichie en tag
US10513718B2 (en) * 2017-06-06 2019-12-24 City University Of Hong Kong Method of producing polyunsaturated fatty acid

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2454404A (en) 1942-10-03 1948-11-23 American Cyanamid Co Preparation of piperazine
US2454504A (en) 1946-01-29 1948-11-23 Franz F Ehrenhaft Nonintermittent cinematographic projector
US4670285A (en) 1982-08-06 1987-06-02 The University Of Toronto Innovations Foundation Infant formula
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5107065A (en) 1986-03-28 1992-04-21 Calgene, Inc. Anti-sense regulation of gene expression in plant cells
US5188958A (en) 1986-05-29 1993-02-23 Calgene, Inc. Transformation and foreign gene expression in brassica species
US5004863B2 (en) 1986-12-03 2000-10-17 Agracetus Genetic engineering of cotton plants and lines
US5416011A (en) 1988-07-22 1995-05-16 Monsanto Company Method for soybean transformation and regeneration
AU1871492A (en) 1991-03-29 1992-11-02 Board Of Trustees Of The University Of Illinois, The Production fo transgenic soybean plants
US6372965B1 (en) 1992-11-17 2002-04-16 E.I. Du Pont De Nemours And Company Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants
US6432684B1 (en) 1997-04-11 2002-08-13 Abbott Laboratories Human desaturase gene and uses thereof
US5972664A (en) 1997-04-11 1999-10-26 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
US6051754A (en) 1997-04-11 2000-04-18 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants
TR199902474T2 (xx) 1997-04-11 2000-02-21 Calgene Llc Bitkilerde uzun zincirli �ok-doymam�� ya�l� asitlerin sentezi i�in y�ntemler ve bile�imler.
US6075183A (en) 1997-04-11 2000-06-13 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants
US5968809A (en) 1997-04-11 1999-10-19 Abbot Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
EP1003869A1 (en) 1997-06-04 2000-05-31 Calgene LLC Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants
ES2293726T3 (es) * 1998-06-12 2008-03-16 Calgene Llc Acidos grasos poliinsaturados en plantas.
US6677145B2 (en) 1998-09-02 2004-01-13 Abbott Laboratories Elongase genes and uses thereof
US6403349B1 (en) 1998-09-02 2002-06-11 Abbott Laboratories Elongase gene and uses thereof
US6825017B1 (en) 1998-12-07 2004-11-30 Washington State University Research Foundation Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
EP1147174B1 (en) 1998-12-07 2007-02-14 Washington State University Research Foundation Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
BR0108198A (pt) 2000-02-09 2003-03-25 Basf Ag ácido nucleico isolado, construção de gene, sequência de aminoácidos, vetor, organismo, anticorpo, molécula de ácido nucleico anti-sentido, processo para a preparação de pufas, óleo, lipìdeo ou ácido graxo ou uma fração destes, composição, uso da composição oleaginosa, lipìdica ou de ácido graxo, kit, e, processo para identificar um antagonista de elongases
EP1297163B1 (en) 2000-06-23 2011-04-27 E.I. Du Pont De Nemours And Company Recombinant constructs and their use in reducing gene expression
AU2001270244A1 (en) 2000-06-28 2002-01-08 Monsanto Technology Llc Plant regulatory sequences for selective control of gene expression
SI1309698T1 (sl) 2000-07-21 2007-08-31 Du Pont Citokrom p450 encim zdruĺ˝en s sintezo delta-12-epoksi skupin v maĺ äśobnih kislinah rastlin
EP1322752B2 (en) 2000-09-28 2015-02-11 Bioriginal Food & Science Corp. Fad4, fad5, fad5-2, and fad6, fatty acid desaturase family members and uses thereof
GB0107510D0 (en) * 2001-03-26 2001-05-16 Univ Bristol New elongase gene and a process for the production of -9-polyunsaturated fatty acids
TWI350854B (en) 2001-04-16 2011-10-21 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
AU2003296638B2 (en) * 2002-12-19 2009-06-11 University Of Bristol Method for the production of polyunsaturated fatty acids
US20040172682A1 (en) 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
US7129089B2 (en) 2003-02-12 2006-10-31 E. I. Du Pont De Nemours And Company Annexin and P34 promoters and use in expression of transgenic genes in plants
WO2004090123A2 (de) * 2003-04-08 2004-10-21 Basf Plant Science Gmbh Δ-4-desaturasen aus euglena gracilis, exprimierende pflanzen und pufa enthaltende öle
US7238482B2 (en) 2003-05-07 2007-07-03 E. I. Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
US7125672B2 (en) 2003-05-07 2006-10-24 E. I. Du Pont De Nemours And Company Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
US7259255B2 (en) 2003-06-25 2007-08-21 E. I. Du Pont De Nemours And Company Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast
MX342029B (es) 2003-08-01 2016-09-12 Basf Plant Science Gmbh * Metodo para la produccion de acidos grasos poli - insaturados en organismos transgenicos.
US6953287B2 (en) 2003-11-06 2005-10-11 3M Innovative Properties Company Anchor for fiber optic cable
CA2542574C (en) 2003-11-12 2014-03-18 E. I. Du Pont De Nemours And Company Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous plants and yeast
EP1723220B1 (de) 2004-02-27 2013-04-10 BASF Plant Science GmbH Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen pflanzen
WO2005103253A1 (en) 2004-04-22 2005-11-03 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
EP1758991B1 (en) 2004-06-25 2013-01-16 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
US7588931B2 (en) 2004-11-04 2009-09-15 E. I. Du Pont De Nemours And Company High arachidonic acid producing strains of Yarrowia lipolytica

Also Published As

Publication number Publication date
US20130254931A1 (en) 2013-09-26
US20100175148A1 (en) 2010-07-08
AU2006318738A1 (en) 2007-05-31
CN101365788A (zh) 2009-02-11
US8048653B2 (en) 2011-11-01
AU2006318738B2 (en) 2011-12-22
US20070117190A1 (en) 2007-05-24
US20100075387A1 (en) 2010-03-25
JP5123861B2 (ja) 2013-01-23
US7645604B2 (en) 2010-01-12
NO20082466L (no) 2008-08-20
EP1951866A1 (en) 2008-08-06
CA2624661C (en) 2015-06-30
AU2006316610B2 (en) 2012-06-14
US8420892B2 (en) 2013-04-16
CA2625855A1 (en) 2007-05-31
US20070118929A1 (en) 2007-05-24
AU2006316610A1 (en) 2007-05-31
EP1957641A2 (en) 2008-08-20
BRPI0620552A2 (pt) 2011-11-22
US9150874B2 (en) 2015-10-06
US20090119795A1 (en) 2009-05-07
JP2009517019A (ja) 2009-04-30
EP1951866B1 (en) 2014-07-30
WO2007061845A2 (en) 2007-05-31
WO2007061845A3 (en) 2007-08-02
US8049062B2 (en) 2011-11-01
CA2624661A1 (en) 2007-05-31
KR20080071190A (ko) 2008-08-01
CA2625855C (en) 2016-04-19
WO2007061742A1 (en) 2007-05-31
CN101365788B (zh) 2012-11-14

Similar Documents

Publication Publication Date Title
DK1951866T3 (da) Delta-9-elongaser og anvendelse heraf til fremstilling af flerumættede fedtsyrer
DK1888033T3 (da) Fremgangsmåde og sammensætning til behandling af inflammatoriske sygdomme
CY2016029I2 (el) Πρωτεϊνες συνδεσης αντιγονου προς προπρωτεϊνη κονβερτασης σουμπτιλισινης κεχιν τυπου 9(pcsk9)
DK1805312T3 (da) Fremgangsmåder og midler til fremstilling af hyaluronan
DK1871738T3 (da) N-alkylcarbonylaminosyreester- og N-alkylcarbonylaminolactonforbindelser og deres anvendelse
DK1962886T4 (da) Stabile proteinformuleringer
DK2079485T3 (da) Phenylpropionamidforbindelser og anvendelsen deraf
DK3424932T3 (da) Bronophthalider til terapeutisk anvendelse
DK1853271T3 (da) Fremgangsmåde og præparat til behandling af perifere vaskulære sygdomme
ITMI20041571A1 (it) Perfluoroelastomeri
DK1858488T4 (da) Tigecyclinsammensætninger og fremgangsmåder til fremstilling deraf
EP1895838A4 (en) COMPOSITIONS AND METHODS
IS8597A (is) Samsetningar rísedrónats og aðferðir við notkun þess
DK2069467T3 (da) Adskillende sammensætninger og fremgangsmåder til anvendelse
DK1685834T3 (da) Anvendelse af pinolensyre til behandling af obesitet
DE602004025215D1 (de) Tastsonde
DE602005008726D1 (de) Verwendet
DK1922309T3 (da) N-phenyl-2-pyrimidin-aminderivater og fremgangsmåde til fremstillingen deraf
DK1809328T3 (da) Mannooligosaccharid-sammensætning til kropsfedt-reduktion
DK1817055T3 (da) Ovr110-antistofsammensætninger og fremgangsmåder til anvendelse heraf
NO20043305D0 (no) Preparation of lodixanol
DK1896077T3 (da) Fremgangsmåder og sammensætninger til forebyggelse og behandling af inflammatoriske sygdomme
EP1763358A4 (en) COMPOSITIONS AND METHODS FOR SUPPRESSING THE APPETITE
PT1763520E (pt) Utilização de benzopiranonas trissubstituídas
DK1885716T3 (da) Thiazolderivater og anvendelse deraf