DK1919951T3 - Anti-tnf-alfa-antistoffer og fremgangsmåder til anvendelse - Google Patents
Anti-tnf-alfa-antistoffer og fremgangsmåder til anvendelse Download PDFInfo
- Publication number
- DK1919951T3 DK1919951T3 DK06774701.4T DK06774701T DK1919951T3 DK 1919951 T3 DK1919951 T3 DK 1919951T3 DK 06774701 T DK06774701 T DK 06774701T DK 1919951 T3 DK1919951 T3 DK 1919951T3
- Authority
- DK
- Denmark
- Prior art keywords
- ser
- gly
- tyr
- leu
- thr
- Prior art date
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- Health & Medical Sciences (AREA)
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Claims (9)
1. Antistof der er i stand til at binde til TNF-alfa, hvor antistoffet omfatter: (a) et polypeptid omfattende et polypeptid med sekvensen vist i SEQ ID NO: 2; og (b) et polypeptid omfattende et polypeptid med sekvensen vist i SEQ ID NO: 380, hvor antistoffet binder TNF-alfa med affinitet større end den for infliximab som bestemt under anvendelse af et Biacore assay, og hvor infliximab VH-regionen har sekvensen vist i SEQ ID NO: 1 og infliximab VL-regionen har sekvensen vist i SEQ ID NO: 379.
2. Antistof ifølge 1, hvor polypeptidet ifølge krav 1(a) med sekvensen vist i SEQ ID NO:2 har sekvensen vist i SEQ ID NO: 3.
3. Biologisk aktivt fragment af antistoffet ifølge krav 1 eller krav 2.
4. Cellelinje der udtrykker antistoffet ifølge krav 1 eller krav 2 eller det biologisk aktive fragment ifølge krav 3.
5. Cellelinje omfattende en vektor omfattende et polynukleotid der koder for polypeptidet angivet i krav 1(a) eller krav 2 og en vektor omfattende et polynukleotid der koder for polypeptidet angivet i krav 1(b).
6. Cellelinje ifølge krav 5 hvor polynukleotidet der koder for polypeptidet angivet i krav 1 eller krav 2 har sekvensen vist i SEQ ID NO: 191 eller en komplementær sekvens.
7. Cellelinje ifølge krav 5 eller krav 6, hvor polynukleotidet der koder for polypeptidet angivet i krav 1(b) har sekvensen vist i SEQ ID NO: 381 eller en komplementær sekvens.
8. Cellelinjen ifølge et hvilket som helst af kravene 4 til 7 hvor cellelinjen er en HEK293, NSO, SP2/0 eller CHO cellelinje.
9. Farmaceutisk sammensætning omfattende en effektiv mængde af mindst ét antistof ifølge krav 1 eller krav 2 eller af mindst ét biologisk aktivt fragment ifølge krav 3 og en farmaceutisk acceptabel bærer eller diluent.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70542705P | 2005-08-04 | 2005-08-04 | |
| PCT/US2006/029114 WO2007019064A2 (en) | 2005-08-04 | 2006-07-27 | ANTI-TNFα ANTIBODIES AND METHODS OF USE |
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| DK1919951T3 true DK1919951T3 (da) | 2015-02-16 |
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| ES (1) | ES2535426T3 (da) |
| HK (1) | HK1117849A1 (da) |
| PL (1) | PL1919951T3 (da) |
| PT (1) | PT1919951E (da) |
| SI (1) | SI1919951T1 (da) |
| WO (1) | WO2007019064A2 (da) |
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| US7807168B2 (en) | 2007-04-10 | 2010-10-05 | Vaccinex, Inc. | Selection of human TNFα specific antibodies |
| CL2010000019A1 (es) * | 2010-01-11 | 2010-06-11 | Univ Chile | Anticuerpo monoclonal contra el tnf humano y sus fragmentos, secuencias nucleotidicas que lo codifican, vector de expresion y celulas que las contienen, composiciones y kit que comprenden el anticuerpo, uso de los mismos y metodo para su obtencion. |
| US20140085100A1 (en) | 2012-09-25 | 2014-03-27 | Woodstream Corporation | Wireless notification system and method for electronic rodent traps |
| US20140300477A1 (en) | 2012-09-25 | 2014-10-09 | Woodstream Corporation | Wireless notification systems and methods for electronic rodent traps |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6284471B1 (en) | 1991-03-18 | 2001-09-04 | New York University Medical Center | Anti-TNFa antibodies and assays employing anti-TNFa antibodies |
| US5698195A (en) | 1991-03-18 | 1997-12-16 | New York University Medical Center | Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies |
| US5656272A (en) | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
| US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| US5919452A (en) | 1991-03-18 | 1999-07-06 | New York University | Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies |
| DE07012626T1 (de) * | 1991-03-18 | 2010-01-21 | New York University | Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor |
| CU22615A1 (es) * | 1994-06-30 | 2000-02-10 | Centro Inmunologia Molecular | Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos |
| ES2258817T3 (es) * | 1997-05-21 | 2006-09-01 | Biovation Limited | Metodo para la produccion de proteinas no inmunogenas. |
| DK1015576T3 (da) | 1997-09-16 | 2005-08-29 | Egea Biosciences Llc | Fremgangsmåde til fuldstændig kemisk syntese og aggregering af gener og genomer |
| US6835550B1 (en) * | 1998-04-15 | 2004-12-28 | Genencor International, Inc. | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins |
| ATE352559T1 (de) * | 1998-12-08 | 2007-02-15 | Biovation Ltd | Verfahren zur verminderung der immunogenität von proteinen |
| CN1585778A (zh) * | 2001-11-12 | 2005-02-23 | 默克专利有限公司 | 修饰的抗－TNFα抗体 |
| US7101978B2 (en) * | 2003-01-08 | 2006-09-05 | Applied Molecular Evolution | TNF-α binding molecules |
| US20040131613A1 (en) * | 2003-01-08 | 2004-07-08 | Watkins Jeffry D. | TNF-alpha binding molecules |
| US6832823B1 (en) * | 2003-05-30 | 2004-12-21 | Hewlett-Packard Development Company, L.P. | Disabling ink ejection elements to decrease dot placement artifacts in an inkjet printhead |
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2006
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- 2006-07-27 DK DK06774701.4T patent/DK1919951T3/da active
- 2006-07-27 PT PT06774701T patent/PT1919951E/pt unknown
- 2006-07-27 JP JP2008525034A patent/JP2009502195A/ja active Pending
- 2006-07-27 ES ES06774701.4T patent/ES2535426T3/es active Active
- 2006-07-27 EP EP06774701.4A patent/EP1919951B1/en active Active
- 2006-07-27 PL PL06774701T patent/PL1919951T3/pl unknown
- 2006-07-27 WO PCT/US2006/029114 patent/WO2007019064A2/en active Application Filing
- 2006-07-31 US US11/496,129 patent/US7560108B2/en active Active
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2008
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2012
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Also Published As
| Publication number | Publication date |
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| WO2007019064A3 (en) | 2009-04-16 |
| US7790871B2 (en) | 2010-09-07 |
| EP1919951B1 (en) | 2015-01-28 |
| JP5261602B2 (ja) | 2013-08-14 |
| PL1919951T3 (pl) | 2015-07-31 |
| US20070092518A1 (en) | 2007-04-26 |
| JP2009502195A (ja) | 2009-01-29 |
| EP1919951A2 (en) | 2008-05-14 |
| US7560108B2 (en) | 2009-07-14 |
| JP2013034481A (ja) | 2013-02-21 |
| ES2535426T3 (es) | 2015-05-11 |
| HK1117849A1 (en) | 2009-01-23 |
| WO2007019064A2 (en) | 2007-02-15 |
| SI1919951T1 (sl) | 2015-05-29 |
| PT1919951E (pt) | 2015-03-04 |
| US20090012266A1 (en) | 2009-01-08 |
| EP1919951A4 (en) | 2011-01-19 |
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