DK1893747T3 - Isolerede celler og populationer, der omfatter sådanne celler, til behandling af cns-sygdomme - Google Patents

Isolerede celler og populationer, der omfatter sådanne celler, til behandling af cns-sygdomme Download PDF

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Publication number
DK1893747T3
DK1893747T3 DK06766101.7T DK06766101T DK1893747T3 DK 1893747 T3 DK1893747 T3 DK 1893747T3 DK 06766101 T DK06766101 T DK 06766101T DK 1893747 T3 DK1893747 T3 DK 1893747T3
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cells
cell
astrocyte
phenotype
human
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DK06766101.7T
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English (en)
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Daniel Offen
Merav Bahat-Stromza
Eldad Melamed
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Univ Ramot
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/135—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)

Claims (7)

  1. ISOLEREDE CELLER OG POPULATIONER, DER OMFATTER SÅDANNE CELLER, TIL BEHANDLING AF CNS-SYGDOMME
    1. Fremgangsmåde til dannelse af astrocytlignende celler, hvilken fremgangsmåde omfatter: (a) inkubering af mesenkymale stamceller i et medium, som omfatter human epidermal vækstfaktor (hEGF) og human basisk fibroblastvækstfaktor (hbFGF), for at danne celler, som er prædisponeret for at udvikle sig til astrocytlignende celler; og (b) inkubering af de prædisponerede celler i et differentieringsmedium, som omfatter trombocytvækstfaktor (PDGF) og human neuregulin 1-β1, idet der derved dannes astrocytlignende celler.
  2. 2. Fremgangsmåde ifølge krav 1, hvor inkuberingen i trin (b) har en varighed på ca. 48 timer.
  3. 3. Fremgangsmåde ifølge krav 1, hvor koncentrationen af PDGF er ca. 5 ng/ml.
  4. 4. Fremgangsmåde ifølge krav 1, hvor koncentrationen af human neuregulin 1-β1 er ca. 50 ng/ml.
  5. 5. Fremgangsmåde ifølge krav 1, hvor differentieringsmediet endvidere omfatter L-glutamin, dibutyryl-cyklisk AMP og isobutylmethylxanthin IBMX.
  6. 6. Fremgangsmåde ifølge krav 1, hvor koncentrationen af hEGF er ca. 20 ng/ml.
  7. 7. Fremgangsmåde ifølge krav 1, hvor koncentrationen af hbFGF er ca. 20 ng/ml.
DK06766101.7T 2005-06-16 2006-06-18 Isolerede celler og populationer, der omfatter sådanne celler, til behandling af cns-sygdomme DK1893747T3 (da)

Applications Claiming Priority (2)

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US69087905P 2005-06-16 2005-06-16
PCT/IL2006/000699 WO2006134602A2 (en) 2005-06-16 2006-06-18 Isolated cells and populations comprising same for the treatment of cns diseases

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US (3) US8647874B2 (da)
EP (2) EP1893747B1 (da)
JP (1) JP2008546385A (da)
CN (1) CN101243178A (da)
DK (1) DK1893747T3 (da)
ES (1) ES2524996T3 (da)
WO (1) WO2006134602A2 (da)
ZA (1) ZA200711117B (da)

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US8647874B2 (en) 2014-02-11
EP2465924A3 (en) 2013-01-02
JP2008546385A (ja) 2008-12-25
US10869899B2 (en) 2020-12-22
WO2006134602A3 (en) 2007-03-01
EP1893747A2 (en) 2008-03-05
US9879225B2 (en) 2018-01-30
US20140154222A1 (en) 2014-06-05
WO2006134602A2 (en) 2006-12-21
ES2524996T3 (es) 2014-12-16
ZA200711117B (en) 2008-10-29
EP2465924A2 (en) 2012-06-20
EP1893747B1 (en) 2014-09-03
CN101243178A (zh) 2008-08-13
US20090010895A1 (en) 2009-01-08
US20180112185A1 (en) 2018-04-26

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