DK1863905T3 - Fremgangsmåde til aktivering af naturlige dræberceller ved hjælp af tumorcellepræparater in vitro - Google Patents
Fremgangsmåde til aktivering af naturlige dræberceller ved hjælp af tumorcellepræparater in vitro Download PDFInfo
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- DK1863905T3 DK1863905T3 DK06726410.1T DK06726410T DK1863905T3 DK 1863905 T3 DK1863905 T3 DK 1863905T3 DK 06726410 T DK06726410 T DK 06726410T DK 1863905 T3 DK1863905 T3 DK 1863905T3
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4613—Natural-killer cells [NK or NK-T]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2239/26—Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- A—HUMAN NECESSITIES
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/49—Breast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Claims (3)
1. Fremgangsmåde til aktivering af en human naturlig dræber (NK - natural killer)-celle, som omfatter trinet etablering af kontakt mellem NK-cellen in vitro og et aktiverende tumorcellepræparat (ATCP - activating tumour cell preparation), som omfatter intakte humane tumorceller, eller et humant tumorcellemembranpræparat.
2. Fremgangsmåde ifølge krav 1, hvor ATCP omfatter CTV-1-myeloid leukæmi-celler eller et membranpræparat deraf.
3. Fremgangsmåde ifølge et hvilket som helst af ovennævnte krav, hvor ekspression af CD69 under aktivering opreguleres på NK-cellen.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0505508A GB0505508D0 (en) | 2005-03-17 | 2005-03-17 | Method |
| GB0514288A GB0514288D0 (en) | 2005-07-12 | 2005-07-12 | Method |
| PCT/GB2006/000960 WO2006097743A2 (en) | 2005-03-17 | 2006-03-16 | Method for actvating natural killer cells by tumor cell preparation in vitro |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1863905T3 true DK1863905T3 (da) | 2016-04-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06726410.1T DK1863905T3 (da) | 2005-03-17 | 2006-03-16 | Fremgangsmåde til aktivering af naturlige dræberceller ved hjælp af tumorcellepræparater in vitro |
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| Country | Link |
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| US (3) | US8257970B2 (da) |
| EP (2) | EP1863905B1 (da) |
| JP (3) | JP5663135B2 (da) |
| AU (1) | AU2006224313B2 (da) |
| CA (1) | CA2601197C (da) |
| DK (1) | DK1863905T3 (da) |
| ES (1) | ES2566335T3 (da) |
| HK (1) | HK1112483A1 (da) |
| PL (1) | PL1863905T3 (da) |
| WO (1) | WO2006097743A2 (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20090045886A (ko) | 2006-04-14 | 2009-05-08 | 어드밴스드 셀 테크놀로지, 인코포레이티드 | 혈관 콜로니 형성 세포 |
| MX2010012827A (es) * | 2008-05-29 | 2010-12-20 | Transgene Sa | Biomarcador para seleccionar pacientes y metodos relacionados. |
| WO2011004201A1 (en) * | 2009-07-10 | 2011-01-13 | Mark Lowdell | Preserved compositions of activated nk cells and methods of using the same |
| WO2013132256A1 (en) | 2012-03-07 | 2013-09-12 | Ucl Business Plc | Compositions and methods for treating viral-mediated infection and disease in immunocompromised individuals |
| WO2013168978A1 (ko) * | 2012-05-07 | 2013-11-14 | 고려대학교 산학협력단 | 말초혈액단핵구 유래 자연 살해세포의 유도 및 증식 방법 |
| CN104321425B (zh) * | 2012-05-07 | 2018-08-10 | 株式会社Nkmax | 用于诱导和扩增源自外周血单个核细胞的自然杀伤细胞的方法 |
| EP2934555B1 (en) | 2012-12-21 | 2021-09-22 | Astellas Institute for Regenerative Medicine | Methods for production of platelets from pluripotent stem cells |
| US10961506B2 (en) * | 2014-09-04 | 2021-03-30 | Stemcell Technologies Inc. | Soluble antibody complexes for T cell or NK cell activation and expansion |
| WO2018170309A1 (en) * | 2017-03-15 | 2018-09-20 | Immune Ventures, Llc | In vivo priming of natural killer cells |
| US10758567B2 (en) | 2015-09-16 | 2020-09-01 | Immune Ventures LLC | In vivo priming of natural killer cells |
| JP6850297B2 (ja) * | 2015-12-07 | 2021-03-31 | イミューン ベンチャーズ，リミテッド ライアビリティ カンパニーＩｍｍｕｎｅ Ｖｅｎｔｕｒｅｓ， Ｌｌｃ | ナチュラルキラー細胞の生体内プライミング |
| AU2019215034C1 (en) | 2018-02-01 | 2022-01-06 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| CN113015744A (zh) | 2018-08-30 | 2021-06-22 | Hcw生物科技公司 | 单链嵌合多肽和多链嵌合多肽以及其用途 |
| JP6838750B2 (ja) * | 2019-01-21 | 2021-03-03 | 株式会社ガイアバイオメディシン | Ｎｋ細胞を含む細胞集団の製造方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998049268A1 (en) * | 1997-04-30 | 1998-11-05 | Hans Klingemann | Natural killer cell lines and methods of use |
| US6849452B1 (en) * | 1998-03-03 | 2005-02-01 | Institut Gustave Roussy | Methods for activating natural killer (NK) cells and means for carrying out said methods |
| DE602004027888D1 (de) | 2003-02-20 | 2010-08-12 | Seattle Genetics Inc | Anti-cd70 antikörper-arzneimittelkonjugate und ihr |
| US7435596B2 (en) * | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
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- 2006-03-16 EP EP06726410.1A patent/EP1863905B1/en not_active Not-in-force
- 2006-03-16 WO PCT/GB2006/000960 patent/WO2006097743A2/en not_active Application Discontinuation
- 2006-03-16 DK DK06726410.1T patent/DK1863905T3/da active
- 2006-03-16 CA CA2601197A patent/CA2601197C/en not_active Expired - Fee Related
- 2006-03-16 EP EP11002652.3A patent/EP2399594B1/en active Active
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Also Published As
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| EP1863905A2 (en) | 2007-12-12 |
| CA2601197A1 (en) | 2006-09-21 |
| US8257970B2 (en) | 2012-09-04 |
| PL1863905T3 (pl) | 2016-07-29 |
| JP2013009686A (ja) | 2013-01-17 |
| JP2015012876A (ja) | 2015-01-22 |
| JP5906168B2 (ja) | 2016-04-20 |
| JP2008536487A (ja) | 2008-09-11 |
| US20140079678A1 (en) | 2014-03-20 |
| CA2601197C (en) | 2017-06-06 |
| US9655925B2 (en) | 2017-05-23 |
| EP2399594B1 (en) | 2019-08-14 |
| JP5663135B2 (ja) | 2015-02-04 |
| AU2006224313A1 (en) | 2006-09-21 |
| ES2566335T3 (es) | 2016-04-12 |
| EP1863905B1 (en) | 2016-01-20 |
| AU2006224313B2 (en) | 2011-08-11 |
| EP2399594A1 (en) | 2011-12-28 |
| WO2006097743A2 (en) | 2006-09-21 |
| WO2006097743A3 (en) | 2006-12-14 |
| HK1112483A1 (zh) | 2008-09-05 |
| US8637308B2 (en) | 2014-01-28 |
| US20080166326A1 (en) | 2008-07-10 |
| US20120328587A1 (en) | 2012-12-27 |
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