DK1863476T3 - Combination of anticholinergics and leukotriene receptor antagonists for the treatment of respiratory diseases - Google Patents
Combination of anticholinergics and leukotriene receptor antagonists for the treatment of respiratory diseases Download PDFInfo
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- DK1863476T3 DK1863476T3 DK06723360.1T DK06723360T DK1863476T3 DK 1863476 T3 DK1863476 T3 DK 1863476T3 DK 06723360 T DK06723360 T DK 06723360T DK 1863476 T3 DK1863476 T3 DK 1863476T3
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- use according
- copd
- glycopyrrolate
- medicament
- combination
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66191805P | 2005-03-16 | 2005-03-16 | |
| PCT/EP2006/002247 WO2006097250A1 (en) | 2005-03-16 | 2006-03-10 | The combination of anticholinergics and leukotriene recptor antagonists for the treatment of repiratory diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1863476T3 true DK1863476T3 (en) | 2016-05-17 |
Family
ID=36570797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06723360.1T DK1863476T3 (en) | 2005-03-16 | 2006-03-10 | Combination of anticholinergics and leukotriene receptor antagonists for the treatment of respiratory diseases |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8268864B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1863476B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4991693B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101128196B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2006224842B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2595791C (cg-RX-API-DMAC7.html) |
| CY (1) | CY1117571T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1863476T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2570332T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20160373T1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE027076T2 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2007011273A (cg-RX-API-DMAC7.html) |
| NO (1) | NO340405B1 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ560206A (cg-RX-API-DMAC7.html) |
| PL (1) | PL1863476T3 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2420285C2 (cg-RX-API-DMAC7.html) |
| SI (1) | SI1863476T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006097250A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050048614A1 (en) * | 2000-06-13 | 2005-03-03 | Children's Medical Center Corporation | Biosynthetic oncolytic molecules and uses therefor |
| CN1856490A (zh) * | 2003-07-28 | 2006-11-01 | 詹森药业有限公司 | 苯并咪唑、苯并噻唑和苯并噁唑衍生物及其作为lta4h调节剂的应用 |
| ES2614090T3 (es) | 2005-12-29 | 2017-05-29 | Celtaxsys, Inc. | Derivados de diamina como inhibidores de leucotrieno A4 hidrolasa |
| CL2008000468A1 (es) * | 2007-02-14 | 2008-08-22 | Janssen Pharmaceutica Nv | Uso de compuestos derivados de heterociclos, inhibidores de leucotrina a4 hidrolasa (lta4h), utiles para tratar o prevenir la dermatitis, acne, infarto al miocardio, dolor, picazon, gingivitis, cancer, artritis, entre otras. |
| ES2671874T3 (es) | 2007-10-18 | 2018-06-11 | Rose U, Llc | Formulaciones tópicas de glicopirrolato |
| NZ584876A (en) * | 2007-10-25 | 2012-06-29 | Merck Frosst Canada Ltd | Inhalation compositions comprising montelukast acid and a pde-4-inhibitor or an inhaled corticosteroid |
| WO2010144628A2 (en) * | 2009-06-09 | 2010-12-16 | Elevation Pharmaceuticals, Inc. | Treatment of chronic obstructive pulmonary disease with nebulized beta 2-agonist or combined nebulized beta 2-agonist and anticholinergic administration |
| US9378456B2 (en) * | 2012-11-19 | 2016-06-28 | Microsoft Technology Licensing, Llc | Task completion |
| US8558008B2 (en) | 2013-02-28 | 2013-10-15 | Dermira, Inc. | Crystalline glycopyrrolate tosylate |
| US9006462B2 (en) | 2013-02-28 | 2015-04-14 | Dermira, Inc. | Glycopyrrolate salts |
| ES2981043T3 (es) | 2013-02-28 | 2024-10-07 | Journey Medical Corp | Procedimiento para fabricar tosilato de glicopirrolato treo |
| EP2968359B1 (en) * | 2013-03-12 | 2021-01-20 | Celltaxis, LLC | Methods of inhibiting leukotriene a4 hydrolase |
| MX2015011677A (es) | 2013-03-14 | 2016-07-08 | Celtaxsys Inc | Inhibidores de leucotrieno a4 hidrolasa. |
| RU2685706C2 (ru) * | 2014-01-10 | 2019-04-23 | Эфиммьюн Лимитед | Фармацевтические композиции, содержащие 15-гэпк, и способы лечения астмы и заболеваний легких с их применением |
| WO2019232306A1 (en) | 2018-05-31 | 2019-12-05 | Celtaxsys, Inc. | Method of reducing pulmonary exacerbations in respiratory disease patients |
| JP2022516729A (ja) * | 2019-01-10 | 2022-03-02 | ジャンイン ムコケア ファーマシューティカル カンパニー，リミテッド | ロイコトリエン受容体アンタゴニストを含有する新たな製剤 |
| NZ790643A (en) * | 2020-02-03 | 2023-05-26 | Taro Pharma Ind | Topical montelukast formulations |
| CN115792229B (zh) * | 2022-01-28 | 2024-06-18 | 华中科技大学同济医学院附属同济医院 | 鼻分泌物中tPA在制备鼻息肉及其预后检测剂中的应用 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0435038A (ja) * | 1990-05-31 | 1992-02-05 | Oki Electric Ind Co Ltd | 半導体素子及びその製造方法 |
| CZ290266B6 (cs) * | 1993-07-02 | 2002-06-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituované benzamidy, způsob jejich výroby a farmaceutické prostředky s jejich obsahem |
| US6204285B1 (en) | 1996-07-01 | 2001-03-20 | Sepracor Inc. | Methods and compositions for treating urinary incontinence using enantiomerically enriched (R,R)-glycopyrrolate |
| ES2195121T3 (es) * | 1996-11-11 | 2003-12-01 | Christian R Noe | Uso de una sal farmaceuticamente aceptable de (3r,2'r)-3-((ciclopentilhidroxifenilacetil)oxi)-1,1-dimetilpirrolidinio para la preparacion de un medicamento. |
| CA2281789A1 (en) * | 1997-04-30 | 1998-11-05 | Warner-Lambert Company | Topical nasal antiinflammatory compositions |
| US6384038B1 (en) * | 1998-04-14 | 2002-05-07 | Sepracor Inc. | Methods and compositions using cetirizine in combination with leukotriene inhibitors or decongestants |
| AU7455498A (en) * | 1998-05-29 | 1999-12-20 | Citizen Watch Co. Ltd. | Method of subjecting ink jet printer to preuse treatment |
| CN1150890C (zh) * | 1998-08-04 | 2004-05-26 | 杰格研究股份公司 | 药用气溶胶制剂 |
| NZ511527A (en) * | 1998-11-13 | 2002-10-25 | Jago Res A | Dry powder for inhalation |
| US6086914A (en) * | 1999-03-12 | 2000-07-11 | Weinstein; Robert E. | Nonsedating formulations for allergic rhinitis which possess antihistaminic and anticholinergic activity |
| DE19921693A1 (de) * | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
| US20040002548A1 (en) * | 1999-05-12 | 2004-01-01 | Boehringer Ingelheim Pharma Kg | Medicament compositions containing anticholinergically-effective compounds and betamimetics |
| SE9903995D0 (sv) * | 1999-11-03 | 1999-11-03 | Astra Ab | New combination |
| DE19961300A1 (de) * | 1999-12-18 | 2001-06-21 | Asta Medica Ag | Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator |
| DE10007203A1 (de) * | 2000-02-17 | 2001-08-23 | Asta Medica Ag | Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis |
| GB0008660D0 (en) | 2000-04-07 | 2000-05-31 | Arakis Ltd | The treatment of respiratory diseases |
| GB0009583D0 (en) | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Respiratory formulations |
| DE10110772A1 (de) | 2001-03-07 | 2002-09-12 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren |
| YU33103A (sh) * | 2000-10-31 | 2006-05-25 | Boehringer Ingelheim Pharma Gmbh. & Co.Kg. | Formulacija rastvora za inhalaciju sa soli tiotropijuma |
| GB0029903D0 (en) * | 2000-12-07 | 2001-01-24 | Arakis Ltd | Use of anti-muscarinic agents |
| ES2292713T3 (es) | 2001-03-30 | 2008-03-16 | Jagotec Ag | Formulaciones medicinales en aerosol. |
| US6667344B2 (en) * | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
| JP2004530705A (ja) | 2001-05-25 | 2004-10-07 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 閉塞性気道疾患及びその他の炎症性疾患を治療するためのｐｄｅ４インヒビター及びチオトロピウム又はその誘導体の組み合わせ |
| KR20040007605A (ko) | 2001-05-25 | 2004-01-24 | 화이자 인코포레이티드 | 폐색성 기도 질환을 치료하기 위한 ｐｄｅ4 억제제 및항콜린제의 복합물 |
| GB0118373D0 (en) | 2001-07-27 | 2001-09-19 | Glaxo Group Ltd | Novel therapeutic method |
| MY148466A (en) * | 2001-10-26 | 2013-04-30 | Merck Frosst Canada Ltd | Granule formulation |
| US7258118B2 (en) | 2002-01-24 | 2007-08-21 | Sofotec Gmbh & Co, Kg | Pharmaceutical powder cartridge, and inhaler equipped with same |
| EP1369113B1 (en) * | 2002-06-06 | 2006-11-22 | CHIESI FARMACEUTICI S.p.A. | Solubilisation of drugs in HFA propellant by means of emulsions |
| US20040038958A1 (en) * | 2002-07-11 | 2004-02-26 | Chris Rundfeldt | Topical treatment of skin diseases |
| UA82323C2 (uk) * | 2002-08-09 | 2008-04-10 | Меда Фарма Гмбх & Ко. Кг | Нова комбінація глюкокортикоїду та pde-інгібітору для лікування респіраторних захворювань, алергічних захворювань, астми та хронічних обструктивних легеневих захворювань |
| AU2003272450A1 (en) * | 2002-09-13 | 2004-04-30 | C. Steven Smith | Novel composition and method for treatment of upper respiratory conditions |
| WO2004054556A1 (en) * | 2002-12-13 | 2004-07-01 | Adagit | Pharmaceutical porous particles |
| EP1452179A1 (en) * | 2003-02-27 | 2004-09-01 | CHIESI FARMACEUTICI S.p.A. | Novel medicament combination of a highly potent long-lasting beta2-agonist and a corticosteroid |
| EP1610787B1 (en) * | 2003-03-28 | 2008-01-23 | Nycomed GmbH | Synergistic combination comprising roflumilast and an anticholinergic agent selected from tiotropium salts for the treatment of respiratory diseases |
| JPWO2005055999A1 (ja) | 2003-12-08 | 2007-07-05 | 日本新薬株式会社 | 抗コリン作用剤 |
| GB0411056D0 (en) * | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
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2006
- 2006-03-10 HU HUE06723360A patent/HUE027076T2/en unknown
- 2006-03-10 CN CN2006800061530A patent/CN101128196B/zh not_active Expired - Fee Related
- 2006-03-10 CA CA2595791A patent/CA2595791C/en not_active Expired - Fee Related
- 2006-03-10 WO PCT/EP2006/002247 patent/WO2006097250A1/en not_active Ceased
- 2006-03-10 HR HRP20160373TT patent/HRP20160373T1/hr unknown
- 2006-03-10 EP EP06723360.1A patent/EP1863476B1/en active Active
- 2006-03-10 MX MX2007011273A patent/MX2007011273A/es active IP Right Grant
- 2006-03-10 AU AU2006224842A patent/AU2006224842B2/en not_active Ceased
- 2006-03-10 RU RU2007138270/15A patent/RU2420285C2/ru not_active Application Discontinuation
- 2006-03-10 ES ES06723360T patent/ES2570332T3/es active Active
- 2006-03-10 PL PL06723360T patent/PL1863476T3/pl unknown
- 2006-03-10 DK DK06723360.1T patent/DK1863476T3/en active
- 2006-03-10 JP JP2008501208A patent/JP4991693B2/ja not_active Expired - Fee Related
- 2006-03-10 NZ NZ560206A patent/NZ560206A/en unknown
- 2006-03-10 SI SI200632036A patent/SI1863476T1/sl unknown
- 2006-03-16 US US11/376,615 patent/US8268864B2/en not_active Expired - Fee Related
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2007
- 2007-10-16 NO NO20075287A patent/NO340405B1/no not_active IP Right Cessation
-
2016
- 2016-04-28 CY CY20161100365T patent/CY1117571T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1863476B1 (en) | 2016-02-03 |
| AU2006224842A1 (en) | 2006-09-21 |
| NO20075287L (no) | 2007-12-05 |
| EP1863476A1 (en) | 2007-12-12 |
| CN101128196A (zh) | 2008-02-20 |
| HRP20160373T1 (hr) | 2016-05-06 |
| HK1114013A1 (en) | 2008-10-24 |
| MX2007011273A (es) | 2007-11-08 |
| JP4991693B2 (ja) | 2012-08-01 |
| CY1117571T1 (el) | 2017-04-26 |
| PL1863476T3 (pl) | 2016-07-29 |
| RU2420285C2 (ru) | 2011-06-10 |
| WO2006097250A1 (en) | 2006-09-21 |
| CA2595791C (en) | 2013-10-08 |
| NO340405B1 (no) | 2017-04-18 |
| US20060211729A1 (en) | 2006-09-21 |
| JP2008533072A (ja) | 2008-08-21 |
| AU2006224842B2 (en) | 2011-09-29 |
| RU2007138270A (ru) | 2009-04-27 |
| NZ560206A (en) | 2009-09-25 |
| CN101128196B (zh) | 2013-01-02 |
| SI1863476T1 (sl) | 2016-05-31 |
| HUE027076T2 (en) | 2016-08-29 |
| ES2570332T3 (es) | 2016-05-17 |
| US8268864B2 (en) | 2012-09-18 |
| CA2595791A1 (en) | 2006-09-21 |
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