DK1807156T3 - NEW PHARMACEUTICAL FORMS USED FOR TREATMENT OF SLEEPABILITY - Google Patents
NEW PHARMACEUTICAL FORMS USED FOR TREATMENT OF SLEEPABILITY Download PDFInfo
- Publication number
- DK1807156T3 DK1807156T3 DK05798488.2T DK05798488T DK1807156T3 DK 1807156 T3 DK1807156 T3 DK 1807156T3 DK 05798488 T DK05798488 T DK 05798488T DK 1807156 T3 DK1807156 T3 DK 1807156T3
- Authority
- DK
- Denmark
- Prior art keywords
- formulation
- approx
- sleep
- drug
- carrier particles
- Prior art date
Links
- 239000000203 mixture Substances 0.000 claims 38
- 238000009472 formulation Methods 0.000 claims 34
- 239000002245 particle Substances 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 6
- 206010022437 insomnia Diseases 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
- 239000011230 binding agent Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 230000001737 promoting effect Effects 0.000 claims 4
- 239000003826 tablet Substances 0.000 claims 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 3
- 229930195725 Mannitol Natural products 0.000 claims 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 239000000314 lubricant Substances 0.000 claims 3
- 239000000594 mannitol Substances 0.000 claims 3
- 235000010355 mannitol Nutrition 0.000 claims 3
- 238000002156 mixing Methods 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
- 238000007906 compression Methods 0.000 claims 2
- 230000006835 compression Effects 0.000 claims 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 2
- 239000011859 microparticle Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 2
- GUBGYTABKSRVRQ-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical group OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O GUBGYTABKSRVRQ-UHFFFAOYSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 claims 1
- 229960001681 croscarmellose sodium Drugs 0.000 claims 1
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 claims 1
- 238000007907 direct compression Methods 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 210000002200 mouth mucosa Anatomy 0.000 claims 1
- 239000006190 sub-lingual tablet Substances 0.000 claims 1
- 229940098466 sublingual tablet Drugs 0.000 claims 1
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 claims 1
- 229960001475 zolpidem Drugs 0.000 claims 1
- VXRDAMSNTXUHFX-CEAXSRTFSA-N zolpidem tartrate Chemical group OC(=O)[C@H](O)[C@@H](O)C(O)=O.N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1.N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 VXRDAMSNTXUHFX-CEAXSRTFSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Anesthesiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0423800.2A GB0423800D0 (en) | 2004-10-27 | 2004-10-27 | New pharmaceutical formulations |
| PCT/GB2005/004147 WO2006046041A1 (en) | 2004-10-27 | 2005-10-26 | New pharmaceutical formulations useful in the treatment of insomnia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1807156T3 true DK1807156T3 (en) | 2017-01-23 |
Family
ID=33515600
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11002406.4T DK2340872T3 (en) | 2004-10-27 | 2005-10-26 | New pharmaceutical formulations useful in the treatment of insomnia |
| DK05798488.2T DK1807156T3 (en) | 2004-10-27 | 2005-10-26 | NEW PHARMACEUTICAL FORMS USED FOR TREATMENT OF SLEEPABILITY |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11002406.4T DK2340872T3 (en) | 2004-10-27 | 2005-10-26 | New pharmaceutical formulations useful in the treatment of insomnia |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9265720B2 (enExample) |
| EP (2) | EP2340872B1 (enExample) |
| JP (1) | JP5064226B2 (enExample) |
| CY (2) | CY1118414T1 (enExample) |
| DK (2) | DK2340872T3 (enExample) |
| ES (1) | ES2610469T3 (enExample) |
| GB (1) | GB0423800D0 (enExample) |
| HU (1) | HUE030609T2 (enExample) |
| LT (2) | LT1807156T (enExample) |
| PL (2) | PL2340872T3 (enExample) |
| PT (2) | PT1807156T (enExample) |
| SI (2) | SI2340872T1 (enExample) |
| WO (1) | WO2006046041A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130116378A (ko) | 2004-02-17 | 2013-10-23 | 트랜스셉트 파마슈티칼스, 인코포레이티드 | 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법 |
| US20070287740A1 (en) | 2005-05-25 | 2007-12-13 | Transcept Pharmaceuticals, Inc. | Compositions and methods of treating middle-of-the night insomnia |
| US20060281783A1 (en) * | 2005-05-25 | 2006-12-14 | Transoral Pharmaceuticals, Inc. | Compositions and methods of treating middle-of-the night insomnia |
| WO2008067549A2 (en) * | 2006-11-30 | 2008-06-05 | Transcept Pharmaceuticals, Inc. | Stabilized zolpidem pharmaceutical compositions |
| WO2008075372A1 (en) * | 2006-12-18 | 2008-06-26 | Lupin Limited | Controlled release dosage forms of zolpidem |
| US20080280947A1 (en) * | 2007-05-10 | 2008-11-13 | Blondino Frank E | Anti-insomnia compositions and methods |
| BRPI0914164B1 (pt) * | 2008-06-20 | 2019-04-30 | Merck Patent Gmbh | Comistura para produção de comprimidos de desintegração rápida em um processo de formação de comprimido direto, seus usos, e formulações de comprimido |
| EP2437730A4 (en) * | 2009-05-20 | 2014-02-26 | Lingual Consegna Pty Ltd | ORAL AND / OR SUBLINGUAL THERAPEUTIC FORMULATION |
| CN105581991A (zh) * | 2015-12-28 | 2016-05-18 | 安徽省逸欣铭医药科技有限公司 | 一种酒石酸唑吡坦舌下片及其制备方法 |
| BR112021006551A2 (pt) | 2018-10-08 | 2021-07-06 | Troikaa Pharmaceuticals Ltd | solução não aquosa estável de zolpidem ou seus sais farmaceuticamente aceitáveis |
| CN111939133A (zh) * | 2019-05-16 | 2020-11-17 | 鲁南制药集团股份有限公司 | 一种酒石酸唑吡坦片及其制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK152744C (da) | 1982-08-13 | 1988-10-31 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat |
| SE8800080L (sv) | 1988-01-13 | 1989-07-14 | Kabivitrum Ab | Laekemedelskomposition |
| SE8803935L (sv) | 1988-10-31 | 1990-05-01 | Kabivitrum Ab | Laekemedelskomposition |
| JPH0665103A (ja) | 1992-08-13 | 1994-03-08 | ▲寛▼治 ▲高▼田 | 向精神薬のための速吸収性舌下投与製剤 |
| US7632517B2 (en) | 1997-10-01 | 2009-12-15 | Novadel Pharma Inc. | Buccal, polar and non-polar spray containing zolpidem |
| US6200604B1 (en) | 1998-03-27 | 2001-03-13 | Cima Labs Inc. | Sublingual buccal effervescent |
| SE9803239D0 (sv) | 1998-09-24 | 1998-09-24 | Diabact Ab | Composition for the treatment of acute pain |
| SE9803240D0 (sv) | 1998-09-24 | 1998-09-24 | Diabact Ab | A pharmaceutical composition having a rapid action |
| EP1005863A1 (en) | 1998-12-04 | 2000-06-07 | Synthelabo | Controlled-release dosage forms comprising a short acting hypnotic or a salt thereof |
| AU7937500A (en) * | 1999-10-27 | 2001-05-08 | Farmarc Nederland Bv | Pharmaceutical composition containing midazolam |
| AU5066101A (en) | 2000-04-13 | 2001-10-30 | Synthon B.V. | Modified release formulations containing a hypnotic agent |
| CN1290525A (zh) | 2000-10-10 | 2001-04-11 | 北京万全阳光医药科技有限公司 | 冷冻干燥的扎来普隆速溶口服组合物 |
| US20040176359A1 (en) | 2001-02-20 | 2004-09-09 | University Of Kentucky Research Foundation | Intranasal Benzodiazepine compositions |
| US20030035839A1 (en) * | 2001-05-15 | 2003-02-20 | Peirce Management, Llc | Pharmaceutical composition for both intraoral and oral administration |
| WO2002094230A1 (en) | 2001-05-24 | 2002-11-28 | Alexza Molecular Delivery Corporation | Delivery of sedative-hypnotics trough an inhalation route |
| KR20040099262A (ko) * | 2002-01-10 | 2004-11-26 | 바이오베일 라보라토리즈 인크. | 비-벤조디아제핀계 진정제 제제 |
| US20050147666A1 (en) * | 2002-03-06 | 2005-07-07 | Kyowa Hakko Kogyo Co., Ltd. | Tablets quickly disintegrating in oral cavity |
| US20050208127A1 (en) * | 2002-06-10 | 2005-09-22 | Kazuyoshi Ogasawara | Rapidly disintegrating tablet and process for producing the same |
| ES2199061B1 (es) * | 2002-06-10 | 2005-02-16 | Laboratorios Vita, S.A. | Comprimidos bucodispersables y procedimiento para su obtencion. |
| US20050038042A1 (en) | 2002-11-15 | 2005-02-17 | Jenet Codd | Modified release composition comprising a short-acting hypnotic for treatment of sleep disorders |
| CN1418631A (zh) * | 2002-12-19 | 2003-05-21 | 王登之 | 治疗失眠的佐匹克隆口腔崩解片及其制备方法 |
| US20040265375A1 (en) * | 2003-04-16 | 2004-12-30 | Platteeuw Johannes J. | Orally disintegrating tablets |
| EP1620075B1 (en) * | 2003-05-07 | 2020-06-24 | Samyang Biopharmaceuticals Corporation | Highly plastic granules for making fast melting tablets |
| US20050215521A1 (en) * | 2003-12-22 | 2005-09-29 | Karim Lalji | Modafinil combination therapy for improving sleep quality |
| CA2556450C (en) | 2004-02-17 | 2013-08-06 | Transoral Pharmaceuticals, Inc. | Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof |
| KR20130116378A (ko) * | 2004-02-17 | 2013-10-23 | 트랜스셉트 파마슈티칼스, 인코포레이티드 | 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법 |
| CN1290525C (zh) * | 2004-07-13 | 2006-12-20 | 赵余庆 | 一种降血糖的植物提取物及其用途 |
-
2004
- 2004-10-27 GB GBGB0423800.2A patent/GB0423800D0/en not_active Ceased
-
2005
- 2005-10-26 LT LTEP05798488.2T patent/LT1807156T/lt unknown
- 2005-10-26 PT PT57984882T patent/PT1807156T/pt unknown
- 2005-10-26 WO PCT/GB2005/004147 patent/WO2006046041A1/en not_active Ceased
- 2005-10-26 ES ES05798488.2T patent/ES2610469T3/es not_active Expired - Lifetime
- 2005-10-26 DK DK11002406.4T patent/DK2340872T3/en active
- 2005-10-26 US US11/666,361 patent/US9265720B2/en active Active
- 2005-10-26 EP EP11002406.4A patent/EP2340872B1/en not_active Expired - Lifetime
- 2005-10-26 EP EP05798488.2A patent/EP1807156B1/en not_active Expired - Lifetime
- 2005-10-26 JP JP2007538505A patent/JP5064226B2/ja not_active Expired - Lifetime
- 2005-10-26 PT PT110024064T patent/PT2340872T/pt unknown
- 2005-10-26 DK DK05798488.2T patent/DK1807156T3/en active
- 2005-10-26 SI SI200532171T patent/SI2340872T1/sl unknown
- 2005-10-26 HU HUE05798488A patent/HUE030609T2/en unknown
- 2005-10-26 SI SI200532117A patent/SI1807156T1/sl unknown
- 2005-10-26 PL PL11002406T patent/PL2340872T3/pl unknown
- 2005-10-26 PL PL05798488T patent/PL1807156T3/pl unknown
- 2005-10-26 LT LTEP11002406.4T patent/LT2340872T/lt unknown
-
2011
- 2011-07-15 US US13/184,016 patent/US20110268796A1/en not_active Abandoned
-
2012
- 2012-02-22 US US13/402,580 patent/US20120277261A1/en not_active Abandoned
-
2013
- 2013-04-25 US US13/870,737 patent/US9597281B2/en active Active
-
2017
- 2017-01-11 CY CY20171100038T patent/CY1118414T1/el unknown
- 2017-09-26 CY CY20171101007T patent/CY1119580T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| LT2340872T (lt) | 2017-09-11 |
| EP2340872B1 (en) | 2017-07-05 |
| CY1118414T1 (el) | 2017-06-28 |
| DK2340872T3 (en) | 2017-09-18 |
| PT2340872T (pt) | 2017-10-06 |
| HUE030609T2 (en) | 2017-05-29 |
| US9265720B2 (en) | 2016-02-23 |
| LT1807156T (lt) | 2016-12-12 |
| GB0423800D0 (en) | 2004-12-01 |
| SI1807156T1 (sl) | 2017-01-31 |
| JP5064226B2 (ja) | 2012-10-31 |
| US20130230589A1 (en) | 2013-09-05 |
| PT1807156T (pt) | 2017-01-19 |
| US9597281B2 (en) | 2017-03-21 |
| EP1807156A1 (en) | 2007-07-18 |
| US20110268796A1 (en) | 2011-11-03 |
| PL2340872T3 (pl) | 2017-12-29 |
| JP2008517988A (ja) | 2008-05-29 |
| ES2610469T3 (es) | 2017-04-27 |
| PL1807156T3 (pl) | 2017-06-30 |
| CY1119580T1 (el) | 2018-03-07 |
| WO2006046041A1 (en) | 2006-05-04 |
| EP1807156B1 (en) | 2016-10-12 |
| US20120277261A1 (en) | 2012-11-01 |
| EP2340872A1 (en) | 2011-07-06 |
| SI2340872T1 (sl) | 2017-10-30 |
| US20080311208A1 (en) | 2008-12-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9597281B2 (en) | Pharmaceutical formulations useful in the treatment of insomnia | |
| CN102387802B (zh) | 包含羟考酮和纳洛酮的立即释放药物组合物 | |
| JP2001058944A (ja) | 速崩壊性固形製剤 | |
| WO2000078292A1 (en) | Quickly disintegrating solid preparations | |
| US20180214437A1 (en) | New alfentanil composition for the treatment of acute pain | |
| JP2003034655A (ja) | 速崩壊性固形製剤 | |
| JP2006070046A (ja) | 速崩壊性固形製剤 | |
| US20080193526A1 (en) | Pharmaceutical Compositions Useful in the Treatment of Pain | |
| ES2642213T3 (es) | Nuevas formulaciones farmacéuticas útiles en el tratamiento del insomnio |