DK176586A - Leukotrienantagonister - Google Patents

Leukotrienantagonister Download PDF

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Publication number
DK176586A
DK176586A DK176586A DK176586A DK176586A DK 176586 A DK176586 A DK 176586A DK 176586 A DK176586 A DK 176586A DK 176586 A DK176586 A DK 176586A DK 176586 A DK176586 A DK 176586A
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Prior art keywords
leukotriene antagonists
hydrogen
co2r10
alkyl
methoxy
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DK176586A
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Danish (da)
English (en)
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DK176586D0 (da
Inventor
John Gerald Gleason
Ralph Floyd Hall
Thomas Wen-Fu Ku
Carl David Perchonock
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Smithkline Beckman Corp
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Publication of DK176586D0 publication Critical patent/DK176586D0/da
Publication of DK176586A publication Critical patent/DK176586A/da

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    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/12—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton
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    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
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    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
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    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK176586A 1985-04-19 1986-04-17 Leukotrienantagonister DK176586A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72526485A 1985-04-19 1985-04-19
US72526485 1985-04-19

Publications (2)

Publication Number Publication Date
DK176586D0 DK176586D0 (da) 1986-04-17
DK176586A true DK176586A (da) 1986-10-20

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DK176586A DK176586A (da) 1985-04-19 1986-04-17 Leukotrienantagonister

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EP (2) EP0202759B1 (ko)
JP (3) JPS61249958A (ko)
KR (1) KR950003335B1 (ko)
CN (2) CN1008091B (ko)
AT (2) ATE53991T1 (ko)
AU (3) AU595193B2 (ko)
CA (2) CA1276937C (ko)
CY (1) CY1733A (ko)
DE (2) DE3672130D1 (ko)
DK (1) DK176586A (ko)
EG (1) EG18226A (ko)
ES (1) ES8801175A1 (ko)
FI (1) FI88293C (ko)
GR (1) GR860993B (ko)
HK (2) HK106893A (ko)
HU (2) HU198918B (ko)
IE (1) IE58958B1 (ko)
IL (1) IL78495A (ko)
MY (1) MY102219A (ko)
NO (1) NO164414C (ko)
PH (1) PH23745A (ko)
PT (1) PT82394B (ko)
ZA (1) ZA862794B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143931A (en) * 1982-06-24 1992-09-01 Smithkline Beecham Corporation Leukotriene antagonists containing tetrazolyl groups
EP0202759B1 (en) 1985-04-19 1990-06-20 Smithkline Beecham Corporation Leukotriene antagonists
US4937253A (en) * 1985-04-19 1990-06-26 Smithkline Beecham Corporation Ester prodrugs
US5314918A (en) * 1987-06-24 1994-05-24 Smithkline Beecham Corporation Leukotriene antagonists
CA1334200C (en) * 1987-06-24 1995-01-31 James Simpson Frazee Leukotriene antagonists
US4954513A (en) * 1988-12-23 1990-09-04 Smithkline Beecham Corporation Leukotriene antagonists
PT94376A (pt) * 1989-06-14 1991-03-20 Smithkline Beecham Corp Processo de preparacao de derivados de feniloxirano, intermediarios na preparacao de acidos 2-hidroxi-3-(tio substituido)-3-(fenil substituido)carboxilicos, de amidas e esteres
US5110959A (en) * 1989-06-14 1992-05-05 Smithkline Beckman Corp. Process for preparation of epoxy esters and intermediates prepared thereby
KR970002904B1 (ko) * 1990-04-26 1997-03-12 센쥬 세이야꾸 가부시끼가이샤 S-저급지방산 글루타티온 유도체
EP0527175A4 (en) * 1990-05-01 1993-05-05 Smithkline Beecham Corporation 3-naphthyl-3-carboxyalkylthio or oxy substituted alkanoic acid leukotriene antagonists
CA2081462A1 (en) * 1990-05-01 1991-11-02 James S. Frazee Five-membered ring alkanoic acid leukotriene antagonists
JPH06500105A (ja) * 1990-08-01 1994-01-06 スミスクライン・ビーチャム・コーポレイション ２―ヒドロキシ―３―スルフィド―３―フェニルプロパン酸の製造方法およびその製造用中間体
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JPS61249958A (ja) 1986-11-07
EP0358240A2 (en) 1990-03-14
CY1733A (en) 1994-05-06
AU5789790A (en) 1990-12-13
FI88293B (fi) 1993-01-15
MY102219A (en) 1992-05-15
DK176586D0 (da) 1986-04-17
ES554135A0 (es) 1987-12-16
JPH05194460A (ja) 1993-08-03
AU7929187A (en) 1988-03-17
HU198918B (en) 1989-12-28
PT82394B (pt) 1988-08-17
HU196365B (en) 1988-11-28
CN86102482A (zh) 1987-02-04
KR950003335B1 (ko) 1995-04-10
CN1040586A (zh) 1990-03-21
AU604060B2 (en) 1990-12-06
EG18226A (en) 1992-10-30
NO861534L (no) 1986-10-20
ATE53991T1 (de) 1990-07-15
PT82394A (en) 1986-05-01
JPH0474348B2 (ko) 1992-11-26
KR860008131A (ko) 1986-11-12
FI861635A (fi) 1986-10-20
AU595193B2 (en) 1990-03-29
EP0202759A2 (en) 1986-11-26
HUT43812A (en) 1987-12-28
JPH05194302A (ja) 1993-08-03
CN1025564C (zh) 1994-08-03
EP0202759A3 (en) 1988-09-07
FI88293C (fi) 1993-04-26
JPH0643358B2 (ja) 1994-06-08
JPH0692380B2 (ja) 1994-11-16
IL78495A (en) 1993-01-14
CA1314899C (en) 1993-03-23
ES8801175A1 (es) 1987-12-16
EP0358240A3 (en) 1990-06-20
PH23745A (en) 1989-11-03
IE861025L (en) 1986-10-19
IL78495A0 (en) 1986-08-31
EP0358240B1 (en) 1993-06-09
DE3688561D1 (de) 1993-07-15
ATE90330T1 (de) 1993-06-15
DE3672130D1 (de) 1990-07-26
NO164414C (no) 1990-10-03
FI861635A0 (fi) 1986-04-17
AU5605086A (en) 1986-10-23
NO164414B (no) 1990-06-25
HK106893A (en) 1993-10-15
CA1276937C (en) 1990-11-27
EP0202759B1 (en) 1990-06-20
DE3688561T2 (de) 1993-09-23
HK1006838A1 (en) 1999-03-19
GR860993B (en) 1986-08-12
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CN1008091B (zh) 1990-05-23
IE58958B1 (en) 1993-12-01

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