DK175795B1 - Rekombinant eller syntetisk DNA-sekvens, der koder for et FGF-protein, vektor, der indeholder DNA-sekvensen og en rekombinant værtscelle, der indeholder DNA-sekvensen eller vektoren - Google Patents
Rekombinant eller syntetisk DNA-sekvens, der koder for et FGF-protein, vektor, der indeholder DNA-sekvensen og en rekombinant værtscelle, der indeholder DNA-sekvensen eller vektoren Download PDFInfo
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- DK175795B1 DK175795B1 DK198702418A DK241887A DK175795B1 DK 175795 B1 DK175795 B1 DK 175795B1 DK 198702418 A DK198702418 A DK 198702418A DK 241887 A DK241887 A DK 241887A DK 175795 B1 DK175795 B1 DK 175795B1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK200401589A DK176067B1 (da) | 1985-09-12 | 2004-10-18 | Oprenset basisk human-FGF, fremgangsmåde til fremstilling af denne, samt farmaceutisk sammensætning indeholdende denne |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77552185A | 1985-09-12 | 1985-09-12 | |
| US77552185 | 1985-09-12 | ||
| US80916385 | 1985-12-16 | ||
| US06/809,163 US5439818A (en) | 1985-09-12 | 1985-12-16 | DNA encoding human recombinant basic fibroblast growth factor |
| US86938286A | 1986-05-30 | 1986-05-30 | |
| US86938286 | 1986-05-30 | ||
| PCT/US1986/001879 WO1987001728A1 (fr) | 1985-09-12 | 1986-09-11 | Facteurs de croissance de fibroblaste recombinant |
| US8601879 | 1986-09-11 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK241887A DK241887A (da) | 1987-05-12 |
| DK241887D0 DK241887D0 (da) | 1987-05-12 |
| DK175795B1 true DK175795B1 (da) | 2005-02-21 |
Family
ID=27419719
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198702418A DK175795B1 (da) | 1985-09-12 | 1987-05-12 | Rekombinant eller syntetisk DNA-sekvens, der koder for et FGF-protein, vektor, der indeholder DNA-sekvensen og en rekombinant værtscelle, der indeholder DNA-sekvensen eller vektoren |
| DK200401589A DK176067B1 (da) | 1985-09-12 | 2004-10-18 | Oprenset basisk human-FGF, fremgangsmåde til fremstilling af denne, samt farmaceutisk sammensætning indeholdende denne |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK200401589A DK176067B1 (da) | 1985-09-12 | 2004-10-18 | Oprenset basisk human-FGF, fremgangsmåde til fremstilling af denne, samt farmaceutisk sammensætning indeholdende denne |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP0248819B2 (fr) |
| JP (3) | JPH0789936B2 (fr) |
| AT (2) | ATE105868T1 (fr) |
| AU (1) | AU590006B2 (fr) |
| CA (1) | CA1341640C (fr) |
| DE (2) | DE3689845T3 (fr) |
| DK (2) | DK175795B1 (fr) |
| ES (1) | ES2001967A6 (fr) |
| IE (1) | IE66689B1 (fr) |
| IL (1) | IL80022A (fr) |
| WO (1) | WO1987001728A1 (fr) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5235042A (en) * | 1984-02-29 | 1993-08-10 | The Children's Medical Center Corporation | Endothelial cell growth factor |
| US4956455A (en) * | 1984-03-05 | 1990-09-11 | The Salk Institute For Biological Studies | Bovine fibroblast growth factor |
| US4889919A (en) * | 1986-08-13 | 1989-12-26 | Zymogenetics, Inc. | Biologically active PDGF derived A-chain homodimers |
| US5165938A (en) * | 1984-11-29 | 1992-11-24 | Regents Of The University Of Minnesota | Wound healing agents derived from platelets |
| US5401832A (en) * | 1984-12-24 | 1995-03-28 | Merck & Co., Inc. | Brain derived and recombinant acidic fibroblast growth factor |
| IL80944A (en) * | 1985-12-17 | 1994-10-07 | Synergen Inc Boulder Colo U S | A factor in the formation of blood vessels in a human placenta capable of inducing protease synthesis in the inner lining of capillary cells, DNA synthesis. And migration of materials |
| US4994559A (en) * | 1985-12-17 | 1991-02-19 | Synergen, Inc. | Human basic fibroblast growth factor |
| US5026839A (en) * | 1985-12-17 | 1991-06-25 | Synergen, Inc | DNA encoding a basic fibroblast growth factor |
| US5552528A (en) | 1986-03-03 | 1996-09-03 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bovine b-endothelial cell growth factor |
| US4868113A (en) * | 1986-03-03 | 1989-09-19 | Rorer Biotechnology, Inc. | Recombinant DNA vector encoding human endothelial cell growth factor |
| US5827826A (en) | 1986-03-03 | 1998-10-27 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compositions of human endothelial cell growth factor |
| EP0246753B1 (fr) * | 1986-04-22 | 1994-07-13 | The Salk Institute For Biological Studies | Antagonistes du facteur de croissance des fibroblastes |
| NZ220917A (en) * | 1986-07-11 | 1991-05-28 | Merck & Co Inc | Human and bovine acidic fibroblast growth factor vectors, hosts and compositions |
| US5474982A (en) * | 1986-08-13 | 1995-12-12 | Zymogenetics, Inc. | PDGF analogs and methods of use |
| CA1323317C (fr) * | 1987-01-16 | 1993-10-19 | Allen R. Banks | Production de facteur de croissance de fibroblastes |
| JP2526965B2 (ja) * | 1987-02-24 | 1996-08-21 | 武田薬品工業株式会社 | ムテイン，ｄｎａおよびその用途 |
| US5852177A (en) * | 1987-02-24 | 1998-12-22 | Takeda Chemical Industries, Ltd. | Basic fibroblast growth factor (bFGF) muteins |
| ATE116373T1 (de) * | 1987-03-03 | 1995-01-15 | Takeda Chemical Industries Ltd | Monoklonaler antikörper, hybridomen, ihre herstellung und ihre verwendung. |
| AU611614B2 (en) * | 1987-06-18 | 1991-06-13 | Monash University | Growth factors |
| EP0364481A4 (en) * | 1987-06-18 | 1992-01-22 | Monash University | Growth factors |
| DE3721081A1 (de) * | 1987-06-26 | 1989-01-19 | Progen Biotechnik Gmbh | Dna-sequenz, die codiert fuer ein zellteilungsfoerderndes polypeptid, sowie ein plasmid, ein wirtsorganismus und ein verfahren zur gewinnung dieses polypeptids |
| NZ226543A (en) * | 1987-10-22 | 1992-02-25 | Merck & Co Inc | Recombinant mutant acidic fibroblast growth factor |
| US5312911A (en) * | 1987-10-22 | 1994-05-17 | Merck & Co., Inc. | Cysteine-modified acidic fibroblast growth factor |
| WO1989004832A1 (fr) * | 1987-11-24 | 1989-06-01 | Amgen Inc. | Analogues du facteur de croissance de fibroblastes |
| EP0326907A1 (fr) * | 1988-01-26 | 1989-08-09 | Takeda Chemical Industries, Ltd. | Polypeptide, DNA et leur utilisation |
| JPH03503167A (ja) * | 1988-02-24 | 1991-07-18 | アメリカン ナショナル レッド クロス | 部位指定血管形成素子とその使用法 |
| GB2223496B (en) * | 1988-08-08 | 1992-05-27 | British Bio Technology | Synthetic gene encoding mature human acid fibroblast growth factor |
| GB2223495B (en) * | 1988-08-08 | 1992-05-20 | British Bio Technology | Synthetic gene encoding basic fibroblast growth factor |
| GB2223497B (en) * | 1988-08-08 | 1992-04-01 | British Bio Technology | Synthetic gene encoding human beta endothelial cell growth factor |
| US5175147A (en) * | 1988-08-19 | 1992-12-29 | Takeda Chemical Industries, Ltd | Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract |
| EP0441886B1 (fr) * | 1988-11-04 | 1996-08-21 | Chiron Corporation | Expression et traitement de fgf (facteurs de croissance de fibroblaste) acetyles dans de la levure |
| US5656458A (en) * | 1988-11-04 | 1997-08-12 | Chiron Corporation | Expression and processing of amino terminus acetylated FGF's in yeast |
| US5464943A (en) * | 1989-04-26 | 1995-11-07 | Takeda Chemical Industries, Ltd. | DNA encoding glycosylated FGF and production thereof |
| EP0406738A3 (en) * | 1989-07-03 | 1991-08-14 | Takeda Chemical Industries, Ltd. | Production of acidic fgf protein |
| US5126323A (en) * | 1989-11-16 | 1992-06-30 | Genetics Institute, Inc. | Homogeneous purified k-fgf and compositions containing the same |
| IT1237795B (it) * | 1989-12-22 | 1993-06-17 | Erba Carlo Spa | Fattori di crescita fibroblastici per l'uso nella prevenzione e nel trattamento di infezioni virali. |
| US5143829A (en) * | 1990-03-29 | 1992-09-01 | California Biotechnology Inc. | High level expression of basic fibroblast growth factor having a homogeneous n-terminus |
| JPH047617A (ja) * | 1990-04-26 | 1992-01-13 | Canon Inc | 電子機器 |
| JP3135138B2 (ja) * | 1990-12-19 | 2001-02-13 | 科研製薬株式会社 | 骨疾患治療剤 |
| US6833354B1 (en) | 1990-12-19 | 2004-12-21 | Kaken Pharmaceutical Co., Ltd. | Agent for the treatment of bone diseases |
| GR1002610B (el) * | 1991-01-02 | 1997-02-20 | Johnson & Johnson Consumer Products Inc. | Θεραπευτικες συνθεσεις πληγων που περιεχουν παραγοντα αναπτυξης ινοβλαστων και ασκορβικον οξυ. |
| AU1194092A (en) * | 1991-02-06 | 1992-09-07 | Georgetown University | Receptor blocking peptides of fibroblast growth factor receptor |
| EP0499242B1 (fr) * | 1991-02-15 | 1996-06-26 | Takeda Chemical Industries, Ltd. | Stimulation de la formation endosseuse à l'aide d'un facteur de croissance cellulaire |
| US5492894A (en) * | 1991-03-21 | 1996-02-20 | The Procter & Gamble Company | Compositions for treating wrinkles comprising a peptide |
| DE4132005A1 (de) * | 1991-09-26 | 1993-04-01 | Merck Patent Gmbh | Kombination enthaltend wachstumsfaktoren und polyelektrolyte |
| WO1993010806A1 (fr) * | 1991-11-25 | 1993-06-10 | Institute Of Molecular Biology, Inc. | Medicament servant a la promotion de la croissance d'un nerf chez les mammiferes |
| AU659723B2 (en) * | 1992-02-14 | 1995-05-25 | Kaken Pharmaceutical Co., Ltd. | Remedy for airway diseases |
| GB9203533D0 (en) * | 1992-02-19 | 1992-04-08 | Erba Carlo Spa | Use of the conjugate between a fibroblast growth factor and a saporin in treating ocular pathologies |
| US5348941A (en) * | 1992-04-01 | 1994-09-20 | Merck & Co., Inc. | Stabilizers for fibroblast growth factors |
| WO1996040726A1 (fr) | 1995-06-07 | 1996-12-19 | Genta Incorporated | Nouveaux lipides cationiques a base de carbamate |
| MXPA00000009A (es) | 1998-06-22 | 2005-09-08 | Autologous Wound Therapy Inc | Solicitud para patente de utilidad para curativo de heridas mejorado enriquecido con plaquetas. |
| ES2327839T3 (es) * | 1998-09-03 | 2009-11-04 | Novartis Vaccines And Diagnostics, Inc. | Monodosis de fgf-2 eficaz angiogenicamente y metodo de uso. |
| US20030166550A1 (en) | 1999-08-27 | 2003-09-04 | Chiron Corporation | Angiogenically effective unit dose of FGF-2 and method of use |
| US6649072B2 (en) | 2001-11-16 | 2003-11-18 | Robert Brandt | Method for producing autologous platelet-rich plasma |
| AU2003242459B2 (en) | 2002-06-18 | 2007-05-17 | Eisai R&D Management Co., Ltd. | Primary cultured adipocytes for gene therapy |
| WO2005087257A1 (fr) * | 2004-03-16 | 2005-09-22 | Kaken Pharmaceutical Co., Ltd. | Remède pour réparer un tissu cartilagineux ayant un gel de gélatine réticulé en soutien |
| ES2318915B1 (es) * | 2004-12-29 | 2010-02-16 | Universidad De Salamanca | Uso de fgf-2 en celulas precursoras de oligodendrocitos. |
| JP5026987B2 (ja) | 2005-12-22 | 2012-09-19 | Ｈｏｙａ株式会社 | 眼鏡レンズのレンズ面切削加工装置、レンズ面切削加工方法および眼鏡レンズ |
| RU2544367C2 (ru) | 2008-06-26 | 2015-03-20 | НОБЕЛЬФАРМА Ко., ЛТД | Средство для восстановления барабанной перепонки или наружного слухового прохода |
| EP2393828B1 (fr) | 2009-02-03 | 2016-10-12 | Amunix Operating Inc. | Polypeptides recombinants étendus et compositions les comprenant |
| CN104946656B (zh) * | 2015-06-08 | 2018-08-17 | 吉林省农业科学院 | 一种人源碱性成纤维细胞生长因子、烟草叶绿体表达载体及生产方法 |
| CN110151977B (zh) * | 2019-05-29 | 2022-11-29 | 新乡医学院 | 一种保护aFGF蛋白药物稳定性和活性的方法 |
| AU2020382621A1 (en) | 2019-11-13 | 2022-06-02 | Amunix Pharmaceuticals, Inc. | Barcoded XTEN polypeptides and compositions thereof, and methods for making and using the same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4296100A (en) * | 1980-06-30 | 1981-10-20 | Franco Wayne P | Method of treating the heart for myocardial infarction |
| DK161152C (da) * | 1983-03-03 | 1991-11-11 | Genentech Inc | Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat |
| US4444760A (en) * | 1983-06-17 | 1984-04-24 | Merck & Co., Inc. | Purification and characterization of a protein fibroblast growth factor |
| US4956455A (en) * | 1984-03-05 | 1990-09-11 | The Salk Institute For Biological Studies | Bovine fibroblast growth factor |
| JP2770926B2 (ja) * | 1985-12-17 | 1998-07-02 | サイナーゲン インコーポレーテッド | 毛管内皮細胞プロテアーゼ合成、ｄｎａ合成および遊走を促進することの出来るヒト胎盤血管形成誘導因子 |
| US4868113A (en) * | 1986-03-03 | 1989-09-19 | Rorer Biotechnology, Inc. | Recombinant DNA vector encoding human endothelial cell growth factor |
| DK122687A (da) * | 1986-03-14 | 1987-09-15 | Takeda Chemical Industries Ltd | Polypeptid, dna og anvendelse deraf |
| NZ220917A (en) * | 1986-07-11 | 1991-05-28 | Merck & Co Inc | Human and bovine acidic fibroblast growth factor vectors, hosts and compositions |
-
1986
- 1986-09-11 IE IE243286A patent/IE66689B1/en not_active IP Right Cessation
- 1986-09-11 JP JP61504931A patent/JPH0789936B2/ja not_active Expired - Lifetime
- 1986-09-11 DE DE3689845T patent/DE3689845T3/de not_active Expired - Lifetime
- 1986-09-11 EP EP86905648A patent/EP0248819B2/fr not_active Expired - Lifetime
- 1986-09-11 AT AT86905648T patent/ATE105868T1/de not_active IP Right Cessation
- 1986-09-11 AU AU63755/86A patent/AU590006B2/en not_active Expired
- 1986-09-11 WO PCT/US1986/001879 patent/WO1987001728A1/fr active IP Right Grant
- 1986-09-11 DE DE3650774T patent/DE3650774T2/de not_active Expired - Lifetime
- 1986-09-11 AT AT93116673T patent/ATE222602T1/de not_active IP Right Cessation
- 1986-09-11 EP EP93116673A patent/EP0593065B1/fr not_active Expired - Lifetime
- 1986-09-12 IL IL80022A patent/IL80022A/xx unknown
- 1986-09-12 ES ES8601884A patent/ES2001967A6/es not_active Expired
- 1986-09-12 CA CA518137A patent/CA1341640C/fr active Active
-
1987
- 1987-05-12 DK DK198702418A patent/DK175795B1/da not_active IP Right Cessation
-
1993
- 1993-11-26 JP JP5297089A patent/JP2619208B2/ja not_active Expired - Fee Related
-
1996
- 1996-09-24 JP JP8251965A patent/JP2761513B2/ja not_active Expired - Fee Related
-
2004
- 2004-10-18 DK DK200401589A patent/DK176067B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IE66689B1 (en) | 1996-01-24 |
| IL80022A0 (en) | 1986-12-31 |
| DK176067B1 (da) | 2006-03-06 |
| DE3689845T2 (de) | 1994-09-01 |
| DE3650774D1 (de) | 2002-09-26 |
| JPS63500843A (ja) | 1988-03-31 |
| JP2761513B2 (ja) | 1998-06-04 |
| EP0248819A4 (fr) | 1989-02-23 |
| DE3689845T3 (de) | 2001-11-15 |
| DE3650774T2 (de) | 2003-05-28 |
| DK200401589A (da) | 2004-10-18 |
| EP0248819B1 (fr) | 1994-05-18 |
| ATE222602T1 (de) | 2002-09-15 |
| CA1341640C (fr) | 2014-09-16 |
| EP0593065B1 (fr) | 2002-08-21 |
| JPH0767659A (ja) | 1995-03-14 |
| DK241887A (da) | 1987-05-12 |
| ATE105868T1 (de) | 1994-06-15 |
| EP0593065A1 (fr) | 1994-04-20 |
| AU590006B2 (en) | 1989-10-26 |
| EP0248819B2 (fr) | 2000-08-30 |
| DK241887D0 (da) | 1987-05-12 |
| IE862432L (en) | 1987-03-12 |
| DE3689845D1 (de) | 1994-06-23 |
| IE950301L (en) | 1987-03-12 |
| IL80022A (en) | 1993-06-10 |
| JPH09118695A (ja) | 1997-05-06 |
| EP0248819A1 (fr) | 1987-12-16 |
| JP2619208B2 (ja) | 1997-06-11 |
| ES2001967A6 (es) | 1988-07-01 |
| WO1987001728A1 (fr) | 1987-03-26 |
| AU6375586A (en) | 1987-04-07 |
| JPH0789936B2 (ja) | 1995-10-04 |
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| PUP | Patent expired |