DK175264B1 - Anvendelse af benzodiazepinderivater samt benzodiazepinderivater - Google Patents
Anvendelse af benzodiazepinderivater samt benzodiazepinderivater Download PDFInfo
- Publication number
- DK175264B1 DK175264B1 DK198502872A DK287285A DK175264B1 DK 175264 B1 DK175264 B1 DK 175264B1 DK 198502872 A DK198502872 A DK 198502872A DK 287285 A DK287285 A DK 287285A DK 175264 B1 DK175264 B1 DK 175264B1
- Authority
- DK
- Denmark
- Prior art keywords
- benzodiazepine
- dihydro
- methyl
- phenyl
- fluorophenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/22—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62485484A | 1984-06-26 | 1984-06-26 | |
US62485484 | 1984-06-26 | ||
US70527285A | 1985-02-25 | 1985-02-25 | |
US70527285 | 1985-02-25 | ||
US74197285A | 1985-06-10 | 1985-06-10 | |
US74197285 | 1985-06-10 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK287285D0 DK287285D0 (da) | 1985-06-25 |
DK287285A DK287285A (da) | 1986-02-25 |
DK175264B1 true DK175264B1 (da) | 2004-08-02 |
Family
ID=27417360
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK198502872A DK175264B1 (da) | 1984-06-26 | 1985-06-25 | Anvendelse af benzodiazepinderivater samt benzodiazepinderivater |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0167919B1 (es) |
JP (1) | JP2603214B2 (es) |
KR (1) | KR900003406B1 (es) |
AT (1) | ATE88998T1 (es) |
AU (2) | AU4415285A (es) |
CA (1) | CA1332410C (es) |
DE (1) | DE3587316T2 (es) |
DK (1) | DK175264B1 (es) |
ES (2) | ES8704906A1 (es) |
GR (1) | GR851539B (es) |
HK (1) | HK15397A (es) |
IE (1) | IE59900B1 (es) |
IL (1) | IL75587A0 (es) |
NO (1) | NO173651C (es) |
NZ (1) | NZ212502A (es) |
PT (1) | PT80717B (es) |
YU (1) | YU46738B (es) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3586445T2 (de) * | 1984-06-26 | 1993-01-14 | Merck & Co Inc | Kondensierte benzo-laktam-verbindungen und deren pharmazeutische zusammensetzungen. |
US4820834A (en) * | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
US4755508A (en) * | 1984-06-26 | 1988-07-05 | Merck & Co., Inc. | Benzodiazepine analogs and use as antogonists of gastrin and cholecystokinin |
DE3514696A1 (de) * | 1985-04-24 | 1986-11-06 | Bayer Ag, 5090 Leverkusen | N-indolylethyl-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung |
EP0253571B1 (en) * | 1986-07-14 | 1989-08-23 | Merck & Co. Inc. | Process for resolution and race mization of amines with acidic alpha-hydrogens |
JPH01211939A (ja) * | 1988-02-18 | 1989-08-25 | Nec Kyushu Ltd | イオン注入装置 |
FR2630440B1 (fr) * | 1988-04-25 | 1991-09-20 | Jouveinal Sa | Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique |
US4970207A (en) * | 1988-07-07 | 1990-11-13 | Fujisawa Pharmaceutical Company, Ltd. | Benzodiazepine derivatives |
IL91361A (en) * | 1988-09-09 | 1994-10-07 | Fujisawa Pharmaceutical Co | Benzodiazepinone compounds [4,1] connected via positions 1 and 9 and carrying two transducers, processes for their preparation and pharmaceutical preparations containing them |
US4957915A (en) * | 1989-02-27 | 1990-09-18 | Biomeasure, Inc. | Benzodiazepine analogs |
PH26955A (en) * | 1989-03-08 | 1992-12-03 | Kali Chemie Pharma Gmbh | Novel 1,7-fused 1H-indole-2-carboxylic acid N-(1,4-benzodiazepin-3-YL) amides |
ES2104566T3 (es) * | 1989-03-10 | 1997-10-16 | Hoffmann La Roche | Reactivos para la determinacion de drogas. |
EP0727215A3 (en) * | 1989-08-04 | 1996-11-06 | Merck Sharp & Dohme | Central cholecystokinin antagonists for the treatment of psychiatric diseases |
FR2652352A1 (fr) * | 1989-09-28 | 1991-03-29 | Jouveinal Sa | Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique. |
FR2659331A1 (fr) * | 1990-03-08 | 1991-09-13 | Adir | Nouveaux derives de la 4h-pyrrolo [1,2-a] thieno [3,2-f] [1,4]-diazepine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
CA2056809A1 (en) * | 1990-12-07 | 1992-06-08 | Mark G. Bock | Benzodiazepine analogs |
JPH07119217B1 (es) * | 1990-12-25 | 1995-12-20 | ||
IL101514A (en) * | 1991-04-10 | 1996-01-31 | Merck & Co Inc | History of benzodiazepines and anticoagulants containing cholecystokinin containing them |
EP0523845A3 (en) * | 1991-06-14 | 1993-11-18 | Merck & Co Inc | New benzodiazepine analogs |
WO1993007131A1 (en) * | 1991-10-10 | 1993-04-15 | Merck Sharp & Dohme Limited | Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors |
DE69204040T2 (de) * | 1991-12-20 | 1996-03-28 | Merck Sharp & Dohme | 3-Phenylureido-1,4-Benzodiazepinone und ihre Verwendung als Cholecystokinin- oder Gastrinantagonisten. |
GB9203790D0 (en) * | 1992-02-21 | 1992-04-08 | Merck Sharp & Dohme | Therapeutic agents |
US5597915A (en) * | 1992-03-16 | 1997-01-28 | Merck Sharp & Dohme Ltd. | Benzodiazepine derivatives, compositions containing them and their use in therapy |
CA2130196A1 (en) * | 1992-03-24 | 1993-09-30 | Jose Luis Castro Pineiro | Benzodiazepine derivatives |
US5360802A (en) * | 1992-05-11 | 1994-11-01 | Merck Sharpe & Dohme Ltd. | Benzodiazepine derivatives, compositions containing them and their use in therapy |
HUT68208A (en) * | 1992-06-24 | 1995-06-28 | Yamanouchi Pharma Co Ltd | Novel benzodiazepine derivatives and pharmaceutical preparations containing them |
FR2694006A1 (fr) * | 1992-07-22 | 1994-01-28 | Esteve Labor Dr | Amides dérivés de benzohétérocyles. |
JPH08505120A (ja) * | 1992-07-29 | 1996-06-04 | メルク シヤープ エンド ドーム リミテツド | ベンゾジアゼピン誘導体 |
EP0698015A1 (en) * | 1993-05-14 | 1996-02-28 | Genentech, Inc. | Preparation of n-cyanodithioimino-carbonates and 3-mercapto-5-amino-1h-1,2,4-triazole |
AU678503B2 (en) * | 1993-09-24 | 1997-05-29 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds and their use as squalene synthetase inhibitors |
FR2716194B1 (fr) * | 1994-02-14 | 1996-05-31 | Sanofi Elf | Dérivés de 3-acylamino-5-phényl-1,4-benzodiazépin-2-one polysubstitués, leur procédé de préparation et les compositions pharmaceutiques les contenant. |
FR2716195B1 (fr) * | 1994-02-14 | 1996-06-21 | Sanofi Sa | Dérivés de 3-acylamino-5-phényl-1,4-benzodiazépin-2-one polysubstitués, leur procédé de préparation et les compositions pharmaceutiques les contenant. |
MX9701195A (es) * | 1994-08-18 | 1997-05-31 | Merck & Co Inc | 2,3-dihidro-1-(2,2,2-trifluoroetil)-2-oxo-5-fenil-1h-1,4-benzodiazepinas |
EP0776203A4 (en) * | 1994-08-18 | 1997-12-29 | Merck & Co Inc | N-2,3-DIHYDRO-1- (2-PROPYL) -2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPINE |
US5556969A (en) * | 1994-12-07 | 1996-09-17 | Merck Sharp & Dohme Ltd. | Benzodiazepine derivatives |
CA2257948A1 (en) * | 1996-06-28 | 1998-01-08 | Merck & Co., Inc. | Antiarrhythmic combinations of selective iks antagonists with beta-adenergic blocking agents |
US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
US6683075B1 (en) | 1996-12-23 | 2004-01-27 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use |
US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
JP2001521524A (ja) * | 1997-04-14 | 2001-11-06 | シーオーアール セラピューティクス インコーポレイテッド | 選択的Xa因子阻害剤 |
JP2002514214A (ja) | 1997-04-14 | 2002-05-14 | シーオーアール セラピューティクス インコーポレイテッド | 選択的Xa因子阻害剤 |
EP0977772A1 (en) | 1997-04-14 | 2000-02-09 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
US6211183B1 (en) | 1997-04-14 | 2001-04-03 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
US6552013B1 (en) | 1998-06-22 | 2003-04-22 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6958330B1 (en) | 1998-06-22 | 2005-10-25 | Elan Pharmaceuticals, Inc. | Polycyclic α-amino-ε-caprolactams and related compounds |
US6528505B1 (en) | 1998-06-22 | 2003-03-04 | Elan Pharmaceuticals, Inc. | Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6509331B1 (en) | 1998-06-22 | 2003-01-21 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6774125B2 (en) | 1998-06-22 | 2004-08-10 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6569851B1 (en) | 1998-06-22 | 2003-05-27 | Elan Pharmaceutials, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US7160880B1 (en) | 1999-05-14 | 2007-01-09 | Cenes Limited | Short-acting benzodiazepines |
DE60013639T2 (de) | 1999-12-02 | 2005-02-03 | Zeria Pharmaceutical Co., Ltd. | Calciumsalze von 1,5-benzodiazepin-derivaten, verfahren zur herstellung der salze und arzneimittel, die diese enthalten |
GB0012671D0 (en) * | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
EA012387B1 (ru) | 2002-09-20 | 2009-10-30 | Эрроу Терапьютикс Лимитед | Производные бензодиазепина, содержащие их продукт и фармацевтическая композиция и их применение |
CA2514547A1 (en) | 2003-01-28 | 2004-08-12 | Takeda Pharmaceutical Company Limited | Receptor agonists |
AU2005336627A1 (en) | 2005-09-19 | 2007-03-29 | Arrow Therapeutics Limited | Benzodiazepine derivatives for treating hepatitis C infection |
EP2081921B1 (en) | 2006-07-10 | 2010-09-08 | PAION UK Limited | Short-acting benzodiazepine salts and their polymorphic forms |
EP2450039A1 (en) | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
AR094963A1 (es) | 2013-03-04 | 2015-09-09 | Ono Pharmaceutical Co | Reacción de oxidación excelente en el índice de conversión |
GB201414116D0 (en) | 2014-08-08 | 2014-09-24 | Trio Medicines Ltd | Benzodiazepine derivatives |
US9957281B2 (en) | 2015-07-22 | 2018-05-01 | Enanta Pharmaceuticals, Inc. | Benzodiazepine derivatives as RSV inhibitors |
GB201513979D0 (en) * | 2015-08-07 | 2015-09-23 | Trio Medicines Ltd | Synthesis of benzodiazepine derivatives |
EP3178886A1 (en) | 2015-12-10 | 2017-06-14 | DyStar Colours Distribution GmbH | High wet fast brilliant blue disperse dye mixtures |
WO2019006295A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
BR112021018335A2 (pt) | 2019-03-18 | 2021-11-23 | Enanta Pharm Inc | Derivados de benzodiazepina como inibidores de rsv |
WO2020198275A1 (en) * | 2019-03-25 | 2020-10-01 | President And Fellows Of Harvard College | Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment |
US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
WO2021066922A1 (en) | 2019-10-04 | 2021-04-08 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
WO2022010882A1 (en) | 2020-07-07 | 2022-01-13 | Enanta Pharmaceuticals, Inc, | Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors |
WO2022086840A1 (en) | 2020-10-19 | 2022-04-28 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH414653A (de) * | 1959-12-10 | 1966-06-15 | Hoffmann La Roche | Verfahren zur Herstellung von 1,4-Benzodiazepin-Derivaten |
US3297755A (en) * | 1960-12-02 | 1967-01-10 | Hoffmann La Roche | 2-chloro-5-trifluoromethylbenzo-phenone compounds |
US3336295A (en) * | 1960-12-02 | 1967-08-15 | Hoffmann La Roche | Hydroxy or alkoxy substituted 5-phenyl-3h-1, 4-benzodiazepin-2(1h)-ones |
US3402171A (en) * | 1960-12-02 | 1968-09-17 | Hoffmann La Roche | Process for preparing 5-aryl-3h-1, 4-benzodiazepin-2(1h)-ones |
GB1034872A (en) * | 1962-04-16 | 1966-07-06 | American Home Prod | Benzodiazepine derivatives |
NL134421C (es) * | 1963-12-03 | |||
GB1063891A (en) * | 1964-01-14 | 1967-04-05 | Delmar Chem | Method for preparation of benzodiazepinones |
GB1039947A (en) * | 1964-04-06 | 1966-08-24 | Engelhard Ind Inc | Improvements in or relating to gold plating |
GB1173320A (en) * | 1966-12-13 | 1969-12-10 | Delmar Chem | Derivatives of Benzodiazepinones |
US3558603A (en) * | 1967-12-01 | 1971-01-26 | Sumitomo Chemical Co | Process for producing benzodiazepine derivatives |
US3778433A (en) * | 1969-04-18 | 1973-12-11 | Sumitomo Chemical Co | Process for producing benzodiazepine derivatives |
DE1923821A1 (de) * | 1969-05-09 | 1970-11-19 | Wuelfing J A Fa | 1,2,4,5-Tetrahydro-[3H]-benzo-1,4-diazepin-2,5-dion-Derivate,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten |
US3867529A (en) * | 1970-08-24 | 1975-02-18 | Giorgio Ferrari | Tranquilizing and anti-anxiety pharmaceutical compositions |
US4045569A (en) * | 1971-03-17 | 1977-08-30 | Franjo Kajfez | Optically active 1,4-benzodiazepines and process for use as a tranquilizer |
US4065451A (en) * | 1971-03-30 | 1977-12-27 | American Home Products | 1,3-Dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one, substituted diamino acetate esters and their acid salts |
US3801568A (en) * | 1972-02-07 | 1974-04-02 | American Home Prod | Optically active 1,3-dihydro-3-substituted 5-phenyl-2h-1,4-benzodiazepin-2-ones and process for their separation |
CH581606A5 (en) * | 1972-08-02 | 1976-11-15 | Crc Ricerca Chim | 2-(Alpha-ammonio-acylamino) benzophenones - precursors for benzodiazepinone hypnotics and tranquillisers |
DE2311714A1 (de) * | 1973-03-09 | 1974-09-19 | Thomae Gmbh Dr K | Neue 1,4-benzodiazepine |
CH573928A5 (es) * | 1973-07-30 | 1976-03-31 | Crc Ricerca Chim | |
US5004741A (en) * | 1984-06-26 | 1991-04-02 | Merck & Co., Inc. | Methods of antagonizing CCK or gastrin with benzodiazepine analogs |
-
1985
- 1985-06-19 CA CA000484488A patent/CA1332410C/en not_active Expired - Fee Related
- 1985-06-20 IL IL75587A patent/IL75587A0/xx not_active IP Right Cessation
- 1985-06-20 NZ NZ212502A patent/NZ212502A/xx unknown
- 1985-06-24 GR GR851539A patent/GR851539B/el unknown
- 1985-06-25 AU AU44152/85A patent/AU4415285A/en not_active Abandoned
- 1985-06-25 EP EP85107842A patent/EP0167919B1/en not_active Expired - Lifetime
- 1985-06-25 NO NO852558A patent/NO173651C/no unknown
- 1985-06-25 AT AT85107842T patent/ATE88998T1/de not_active IP Right Cessation
- 1985-06-25 DE DE85107842T patent/DE3587316T2/de not_active Expired - Lifetime
- 1985-06-25 ES ES544523A patent/ES8704906A1/es not_active Expired
- 1985-06-25 DK DK198502872A patent/DK175264B1/da not_active IP Right Cessation
- 1985-06-25 IE IE158285A patent/IE59900B1/en not_active IP Right Cessation
- 1985-06-26 KR KR1019850004551A patent/KR900003406B1/ko not_active IP Right Cessation
- 1985-06-26 JP JP60138064A patent/JP2603214B2/ja not_active Expired - Lifetime
- 1985-06-26 YU YU106785A patent/YU46738B/sh unknown
- 1985-06-26 PT PT80717A patent/PT80717B/pt unknown
-
1986
- 1986-01-31 ES ES551504A patent/ES8706132A1/es not_active Expired
-
1989
- 1989-11-10 AU AU44563/89A patent/AU640113B2/en not_active Ceased
-
1997
- 1997-02-05 HK HK15397A patent/HK15397A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PT80717A (en) | 1985-07-01 |
AU640113B2 (en) | 1993-08-19 |
AU4415285A (en) | 1986-01-02 |
EP0167919A2 (en) | 1986-01-15 |
NO173651B (no) | 1993-10-04 |
NZ212502A (en) | 1989-03-29 |
AU4456389A (en) | 1990-04-05 |
ES551504A0 (es) | 1987-06-01 |
ES8706132A1 (es) | 1987-06-01 |
DE3587316T2 (de) | 1993-11-04 |
PT80717B (pt) | 1987-10-20 |
NO173651C (no) | 1994-01-12 |
ATE88998T1 (de) | 1993-05-15 |
ES544523A0 (es) | 1987-04-16 |
YU106785A (en) | 1988-12-31 |
JP2603214B2 (ja) | 1997-04-23 |
DK287285A (da) | 1986-02-25 |
ES8704906A1 (es) | 1987-04-16 |
NO852558L (no) | 1985-12-27 |
EP0167919A3 (en) | 1986-11-05 |
YU46738B (sh) | 1994-04-05 |
KR860000270A (ko) | 1986-01-27 |
GR851539B (es) | 1985-11-25 |
HK15397A (en) | 1997-02-14 |
IE59900B1 (en) | 1994-04-20 |
IL75587A0 (en) | 1985-10-31 |
IE851582L (en) | 1985-12-26 |
JPS6163666A (ja) | 1986-04-01 |
DE3587316D1 (de) | 1993-06-09 |
KR900003406B1 (ko) | 1990-05-18 |
CA1332410C (en) | 1994-10-11 |
EP0167919B1 (en) | 1993-05-05 |
DK287285D0 (da) | 1985-06-25 |
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PUP | Patent expired |