DK174993B1 - Fremgangsmåde til fremstilling af humant antithrombin III (ATIII) samt dertil egnede vektorer og værtsceller - Google Patents

Fremgangsmåde til fremstilling af humant antithrombin III (ATIII) samt dertil egnede vektorer og værtsceller Download PDF

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Publication number
DK174993B1
DK174993B1 DK198703751A DK375187A DK174993B1 DK 174993 B1 DK174993 B1 DK 174993B1 DK 198703751 A DK198703751 A DK 198703751A DK 375187 A DK375187 A DK 375187A DK 174993 B1 DK174993 B1 DK 174993B1
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DK
Denmark
Prior art keywords
atiii
vector
gene
dhfr
dhfr gene
Prior art date
Application number
DK198703751A
Other languages
Danish (da)
English (en)
Other versions
DK375187D0 (da
DK375187A (da
Inventor
Gerd Zettlmeissl
Hermann Ragg
Michael Broeker
Original Assignee
Behringwerke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke Ag filed Critical Behringwerke Ag
Publication of DK375187D0 publication Critical patent/DK375187D0/da
Publication of DK375187A publication Critical patent/DK375187A/da
Application granted granted Critical
Publication of DK174993B1 publication Critical patent/DK174993B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK198703751A 1986-07-19 1987-07-17 Fremgangsmåde til fremstilling af humant antithrombin III (ATIII) samt dertil egnede vektorer og værtsceller DK174993B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3624453 1986-07-19
DE19863624453 DE3624453A1 (de) 1986-07-19 1986-07-19 Verfahren zur herstellung von humanem antithrombin iii (atiii), dafuer geeignete vektoren und wirtszellen, so erhaltenes, biologisch aktives atiii und dieses enthaltende arzneimittel

Publications (3)

Publication Number Publication Date
DK375187D0 DK375187D0 (da) 1987-07-17
DK375187A DK375187A (da) 1988-01-20
DK174993B1 true DK174993B1 (da) 2004-04-13

Family

ID=6305549

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198703751A DK174993B1 (da) 1986-07-19 1987-07-17 Fremgangsmåde til fremstilling af humant antithrombin III (ATIII) samt dertil egnede vektorer og værtsceller

Country Status (11)

Country Link
EP (1) EP0256302B1 (fi)
JP (2) JP2721158B2 (fi)
AT (1) ATE85348T1 (fi)
AU (1) AU610830B2 (fi)
CA (1) CA1305932C (fi)
DE (2) DE3624453A1 (fi)
DK (1) DK174993B1 (fi)
ES (1) ES2053476T3 (fi)
FI (1) FI94425C (fi)
GR (1) GR3007700T3 (fi)
PT (1) PT85346B (fi)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03215430A (ja) * 1990-01-19 1991-09-20 Kita Kiyoshi 関節腔抗凝固剤
DE3901917A1 (de) * 1989-01-24 1990-07-26 Behringwerke Ag Mutanten von humanem antithrombin iii
NZ533133A (en) * 2001-11-28 2006-02-24 Sandoz Ag Method for producing a recombinant polypeptide

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS597693B2 (ja) * 1978-01-07 1984-02-20 株式会社ミドリ十字 抗トロンビン製剤及びその製法
JPS5846100A (ja) * 1981-09-11 1983-03-17 Agency Of Ind Science & Technol ３種の遺伝標識を有するプラスミドベクタ−及びその製造方法
EP0090505B1 (en) * 1982-03-03 1990-08-08 Genentech, Inc. Human antithrombin iii, dna sequences therefor, expression vehicles and cloning vectors containing such sequences and cell cultures transformed thereby, a process for expressing human antithrombin iii, and pharmaceutical compositions comprising it
DE3382068D1 (de) * 1982-03-15 1991-01-31 Univ Columbia Verfahren zum einbringen von klonierten amplifizierbaren genen in eukaryotische zellen und zur herstellung von proteinprodukten.
IL73854A0 (en) * 1983-12-27 1985-03-31 Genetics Inst Vectors containing accessory dna for transformation of eucaryotic cells
IL71691A (en) * 1984-04-27 1991-04-15 Yeda Res & Dev Production of interferon-ypsilon
US4656254A (en) * 1985-12-02 1987-04-07 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor and antithrombin III

Also Published As

Publication number Publication date
AU610830B2 (en) 1991-05-30
JPS6344898A (ja) 1988-02-25
JPH09117293A (ja) 1997-05-06
GR3007700T3 (fi) 1993-08-31
EP0256302A3 (en) 1989-11-02
PT85346B (pt) 1990-06-29
DK375187D0 (da) 1987-07-17
FI94425B (fi) 1995-05-31
DK375187A (da) 1988-01-20
EP0256302A2 (de) 1988-02-24
AU7577387A (en) 1988-03-03
FI873153A0 (fi) 1987-07-16
ES2053476T3 (es) 1994-08-01
FI873153A (fi) 1988-01-20
JP2721158B2 (ja) 1998-03-04
EP0256302B1 (de) 1993-02-03
CA1305932C (en) 1992-08-04
DE3624453A1 (de) 1988-01-28
ATE85348T1 (de) 1993-02-15
JP2798659B2 (ja) 1998-09-17
DE3783968D1 (de) 1993-03-18
FI94425C (fi) 1995-09-11
PT85346A (de) 1987-08-01

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