ES2053476T3 - Procedimiento para la preparacion de antitrombina iii (at iii) humana y vectores apropiados para ello. - Google Patents

Procedimiento para la preparacion de antitrombina iii (at iii) humana y vectores apropiados para ello.

Info

Publication number
ES2053476T3
ES2053476T3 ES87110027T ES87110027T ES2053476T3 ES 2053476 T3 ES2053476 T3 ES 2053476T3 ES 87110027 T ES87110027 T ES 87110027T ES 87110027 T ES87110027 T ES 87110027T ES 2053476 T3 ES2053476 T3 ES 2053476T3
Authority
ES
Spain
Prior art keywords
iii
human
antitrombine
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87110027T
Other languages
English (en)
Inventor
Gerd Dr Zettmeissl
Michael Dr Broker
Hermann Dr Ragg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Application granted granted Critical
Publication of ES2053476T3 publication Critical patent/ES2053476T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA ANTITROMBINA HUMANA III (ATIII), QUE MUESTRA ACTIVIDAD INHIBIDORA PROGRESIVA Y ES ESTIMULADA MEDIANTE LA HEPARINA, SE OBTIENE MEDIANTE EXPRESION DESPUES DE COTRANSFECCION DE CELULAS DE MAMIFEROS, CUYA ACTIVIDAD DE DIHIDROFOLATOREDUCTASA (DHFR) ES DEFICIENTE (DHFR-), CON A) VECTORES QUE CONTIENEN LA ATIII-C ADN Y B) VECTORES QUE LLEVAN EL GEN-DHFR, EN ESPECIAL DESPUES DE AMPLIFICACION DEL GEN CON METOTREXATO.
ES87110027T 1986-07-19 1987-07-11 Procedimiento para la preparacion de antitrombina iii (at iii) humana y vectores apropiados para ello. Expired - Lifetime ES2053476T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863624453 DE3624453A1 (de) 1986-07-19 1986-07-19 Verfahren zur herstellung von humanem antithrombin iii (atiii), dafuer geeignete vektoren und wirtszellen, so erhaltenes, biologisch aktives atiii und dieses enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
ES2053476T3 true ES2053476T3 (es) 1994-08-01

Family

ID=6305549

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87110027T Expired - Lifetime ES2053476T3 (es) 1986-07-19 1987-07-11 Procedimiento para la preparacion de antitrombina iii (at iii) humana y vectores apropiados para ello.

Country Status (11)

Country Link
EP (1) EP0256302B1 (es)
JP (2) JP2721158B2 (es)
AT (1) ATE85348T1 (es)
AU (1) AU610830B2 (es)
CA (1) CA1305932C (es)
DE (2) DE3624453A1 (es)
DK (1) DK174993B1 (es)
ES (1) ES2053476T3 (es)
FI (1) FI94425C (es)
GR (1) GR3007700T3 (es)
PT (1) PT85346B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03215430A (ja) * 1990-01-19 1991-09-20 Kita Kiyoshi 関節腔抗凝固剤
DE3901917A1 (de) * 1989-01-24 1990-07-26 Behringwerke Ag Mutanten von humanem antithrombin iii
CN1596310A (zh) * 2001-11-28 2005-03-16 桑多斯有限公司 产生重组多肽的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS597693B2 (ja) * 1978-01-07 1984-02-20 株式会社ミドリ十字 抗トロンビン製剤及びその製法
JPS5846100A (ja) * 1981-09-11 1983-03-17 Agency Of Ind Science & Technol ３種の遺伝標識を有するプラスミドベクタ−及びその製造方法
GB2116183B (en) * 1982-03-03 1985-06-05 Genentech Inc Human antithrombin iii dna sequences therefore expression vehicles and cloning vectors containing such sequences and cell cultures transformed thereby a process for expressing human antithrombin iii and pharmaceutical compositions comprising it
AU555146B2 (en) * 1982-03-15 1986-09-11 Trustees Of Columbia University In The City Of New York, The Method for intorducing cloned, amplifiable genes into eucaryotic cells and for producing proteinaceous products materials
IL73854A0 (en) * 1983-12-27 1985-03-31 Genetics Inst Vectors containing accessory dna for transformation of eucaryotic cells
IL71691A (en) * 1984-04-27 1991-04-15 Yeda Res & Dev Production of interferon-ypsilon
US4656254A (en) * 1985-12-02 1987-04-07 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor and antithrombin III

Also Published As

Publication number Publication date
PT85346B (pt) 1990-06-29
DK174993B1 (da) 2004-04-13
FI94425C (fi) 1995-09-11
CA1305932C (en) 1992-08-04
DE3624453A1 (de) 1988-01-28
PT85346A (de) 1987-08-01
FI94425B (fi) 1995-05-31
DE3783968D1 (de) 1993-03-18
ATE85348T1 (de) 1993-02-15
FI873153L (fi) 1988-01-20
DK375187A (da) 1988-01-20
JP2721158B2 (ja) 1998-03-04
AU610830B2 (en) 1991-05-30
AU7577387A (en) 1988-03-03
JPS6344898A (ja) 1988-02-25
EP0256302B1 (de) 1993-02-03
EP0256302A3 (en) 1989-11-02
FI873153A0 (fi) 1987-07-16
GR3007700T3 (es) 1993-08-31
EP0256302A2 (de) 1988-02-24
JPH09117293A (ja) 1997-05-06
DK375187D0 (da) 1987-07-17
JP2798659B2 (ja) 1998-09-17

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